Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
RERE	473	broad.mit.edu	37	1	8420616	8420616	+	Missense_Mutation	SNP	T	T	G			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:8420616T>G	uc001ape.3	-	18	3761	c.2951A>C	c.(2950-2952)cAc>cCc	p.H984P	RERE_uc001apf.3_Missense_Mutation_p.H984P|RERE_uc010nzx.1_Missense_Mutation_p.H716P|RERE_uc001apd.3_Missense_Mutation_p.H430P	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	Homo sapiens arginine-glutamic acid dipeptide (RE) repeats (RERE), transcript variant 1, mRNA.	984	Pro-rich.			H -> N (in Ref. 2; no nucleotide entry).	multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGGTGGGGGGTGAGCCGACGG	0.701												
APITD1-CORT	378708	broad.mit.edu	37	1	10511616	10511616	+	Missense_Mutation	SNP	G	G	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:10511616G>T	uc001arf.3	+	4	875	c.459G>T	c.(457-459)agG>agT	p.R153S	APITD1-CORT_uc021ogd.1_3'UTR|APITD1-CORT_uc021ogf.1_Missense_Mutation_p.R132S|APITD1-CORT_uc021ogg.1_Non-coding_Transcript|APITD1-CORT_uc001ari.3_Missense_Mutation_p.R144S	NM_198544	NP_940946	Q8N2Z9	CENPS_HUMAN	Homo sapiens APITD1-CORT readthrough (APITD1-CORT), transcript variant 1, mRNA.	0					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding										TGCCCTGCAGGAACTTCTTCT	0.567												
RSPO1	284654	broad.mit.edu	37	1	38082340	38082340	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:38082340G>A	uc001cbl.2	-	4	994	c.102C>T	c.(100-102)gcC>gcT	p.A34A	RSPO1_uc009vvf.2_Silent_p.A7A|RSPO1_uc001cbm.2_Silent_p.A34A|RSPO1_uc009vvg.2_Silent_p.A34A	NM_001038633	NP_001229837	Q2MKA7	RSPO1_HUMAN	Homo sapiens R-spondin 1 (RSPO1), transcript variant 1, mRNA.	34					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCTCCCCTCGGCACTGACTG	0.557												
RPL5	6125	broad.mit.edu	37	1	93301897	93301898	+	Frame_Shift_Ins	INS	-	-	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:93301897_93301898insT	uc001doz.3	+	4	553_554	c.475_476insT	c.(475-477)gttfs	p.V159fs	FAM69A_uc001dpc.3_Intron|RPL5_uc001dpa.3_Non-coding_Transcript|RPL5_uc001dpb.3_Frame_Shift_Ins_p.V109fs|RPL5_uc001dpd.3_5'UTR|SNORD21_uc001dpe.2_5'Flank|SNORA66_uc021opt.1_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	Homo sapiens ribosomal protein L5 (RPL5), mRNA.	159					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TGGCAATAAAGTTTTTGGTGCC	0.495												
HIPK1	204851	broad.mit.edu	37	1	114515777	114515777	+	Silent	SNP	G	G	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:114515777G>T	uc001eem.3	+	15	3437	c.3276G>T	c.(3274-3276)tcG>tcT	p.S1092S	HIPK1_uc001een.3_Silent_p.S1092S|HIPK1_uc001eeo.3_Silent_p.S718S|HIPK1_uc001eep.3_Silent_p.S698S|HIPK1_uc001eeq.3_Silent_p.S384S	NM_198268	NP_938010	Q86Z02	HIPK1_HUMAN	Homo sapiens homeodomain interacting protein kinase 1 (HIPK1), transcript variant 1, mRNA.	1092	Interaction with TP53.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGCTACACTCGACAGGGCACC	0.647												
CD2	914	broad.mit.edu	37	1	117311264	117311264	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:117311264G>A	uc001egu.4	+	4	944	c.915G>A	c.(913-915)caG>caA	p.Q305Q		NM_001767	NP_001758	P06729	CD2_HUMAN	Homo sapiens CD2 molecule (CD2), mRNA.	305	Pro-rich.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	ACCGTGTTCAGCACCAGCCTC	0.622												
TCHH	7062	broad.mit.edu	37	1	152084995	152084995	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:152084995C>T	uc009wne.1	-	2	970	c.698G>A	c.(697-699)cGg>cAg	p.R233Q	TCHH_uc001ezp.2_Missense_Mutation_p.R233Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	Homo sapiens trichohyalin (TCHH), mRNA.	233					keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGTCTTGCCGCTCTCGCCT	0.577												
PAPPA2	60676	broad.mit.edu	37	1	176526161	176526161	+	Missense_Mutation	SNP	C	C	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:176526161C>A	uc001gkz.3	+	1	1867	c.703C>A	c.(703-705)Cca>Aca	p.P235T	PAPPA2_uc001gky.1_Missense_Mutation_p.P235T|PAPPA2_uc009www.3_Non-coding_Transcript	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	Homo sapiens pappalysin 2 (PAPPA2), transcript variant 1, mRNA.	235					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CAAAAAGAGTCCACCGGAGGA	0.527												
OR11L1	391189	broad.mit.edu	37	1	248004304	248004304	+	Nonsense_Mutation	SNP	C	C	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:248004304C>A	uc001idn.1	-	0	895	c.895G>T	c.(895-897)Gaa>Taa	p.E299*		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	Homo sapiens olfactory receptor, family 11, subfamily L, member 1 (OR11L1), mRNA.	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E299V(1)		NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTAACAGCTTCTTTGAAGTCT	0.393												
AGAP6	414189	broad.mit.edu	37	10	51768724	51768724	+	Missense_Mutation	SNP	G	G	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr10:51768724G>C	uc001jix.4	+	7	1237	c.839G>C	c.(838-840)aGa>aCa	p.R280T		NM_001077665	NP_001071133	C9IYN2	C9IYN2_HUMAN	Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 (AGAP6), mRNA.	280					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.G279C(1)		NS(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(8)|prostate(3)|skin(1)|stomach(2)	29						GGGAGCGGTAGAGCCATCCCC	0.507												
PTEN	5728	broad.mit.edu	37	10	89692835	89692835	+	Missense_Mutation	SNP	G	G	C	rs57374291		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr10:89692835G>C	uc001kfb.3	+	4	1351	c.319G>C	c.(319-321)Gat>Cat	p.D107H	PTEN_uc021pvw.1_Non-coding_Transcript	NM_000314	NP_000305	P60484	PTEN_HUMAN	Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.	107	Phosphatase tensin-type.		D -> Y (in BZS and glioblastoma; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.D107Y(6)|p.?(5)|p.R55fs*1(5)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.D107N(2)|p.D107A(1)|p.F56fs*2(1)|p.P103fs*3(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTTTTGTGAAGATCTTGACCA	0.368		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)		
BNIP3	664	broad.mit.edu	37	10	133787377	133787377	+	Nonsense_Mutation	SNP	A	A	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr10:133787377A>T	uc001lkv.1	-	1	242	c.117T>A	c.(115-117)taT>taA	p.Y39*	BNIP3_uc010qut.1_Nonsense_Mutation_p.Y39*	NM_004052	NP_004043	Q12983	BNIP3_HUMAN	Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3), nuclear gene encoding mitochondrial protein, mRNA.	39					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|skin(1)	7		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TGTCTCCATTATAAATAGAAA	0.517												
MRGPRX4	117196	broad.mit.edu	37	11	18195500	18195500	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:18195500G>A	uc001mnv.1	+	0	1117	c.697G>A	c.(697-699)Ggc>Agc	p.G233S		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	Homo sapiens MAS-related GPR, member X4 (MRGPRX4), mRNA.	233						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.G233S(2)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						CCTGCCCTTCGGCATTCTGGG	0.527												
LRRC4C	57689	broad.mit.edu	37	11	40137192	40137192	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:40137192C>T	uc021qgf.1	-	0	651	c.651G>A	c.(649-651)ccG>ccA	p.P217P	LRRC4C_uc001mxc.1_Silent_p.P213P|LRRC4C_uc001mxd.1_Silent_p.P213P|LRRC4C_uc001mxa.1_Silent_p.P217P|LRRC4C_uc001mxb.1_Silent_p.P213P	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	Homo sapiens leucine rich repeat containing 4C (LRRC4C), mRNA.	217					regulation of axonogenesis	integral to membrane	protein binding	p.P217P(4)		NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTTTTATGAGCGGTGTGAGGT	0.458												
LRRC55	219527	broad.mit.edu	37	11	56950084	56950084	+	Missense_Mutation	SNP	T	T	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:56950084T>A	uc001njl.2	+	0	864	c.717T>A	c.(715-717)aaT>aaA	p.N239K		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	Homo sapiens leucine rich repeat containing 55 (LRRC55), mRNA.	209	LRRCT.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TCGGTGGCAATCCCTGGGTGT	0.632												
DAGLA	747	broad.mit.edu	37	11	61511858	61511858	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:61511858G>A	uc001nsa.3	+	19	3142	c.3026G>A	c.(3025-3027)aGt>aAt	p.S1009N		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	Homo sapiens diacylglycerol lipase, alpha (DAGLA), mRNA.	1009					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		ACGGGCCTCAGTAGCCAGGAA	0.657												
STX5	6811	broad.mit.edu	37	11	62593006	62593006	+	Missense_Mutation	SNP	G	G	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:62593006G>C	uc001nvh.3	-	5	586	c.429C>G	c.(427-429)atC>atG	p.I143M	STX5_uc010rmj.2_Missense_Mutation_p.I143M|STX5_uc010rmi.2_Missense_Mutation_p.I47M	NM_003164	NP_003155	Q13190	STX5_HUMAN	Homo sapiens syntaxin 5 (STX5), transcript variant 1, mRNA.	143					intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			breast(2)|endometrium(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	18						TGAGGCTATTGATGTCCTGGT	0.507												
NUMA1	4926	broad.mit.edu	37	11	71717271	71717271	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:71717271C>T	uc001orl.1	-	21	5674	c.5502G>A	c.(5500-5502)tcG>tcA	p.S1834S	NUMA1_uc001orj.2_Silent_p.S16S|NUMA1_uc009ysw.1_Silent_p.S1401S|NUMA1_uc001ork.1_Silent_p.S698S|NUMA1_uc001orm.1_Silent_p.S1820S	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	Homo sapiens nuclear mitotic apparatus protein 1 (NUMA1), mRNA.	1834					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						TGCTGTAGAACGATGAGTTGG	0.552			T	RARA	APL							
FOLR4	390243	broad.mit.edu	37	11	94040846	94040846	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:94040846G>A	uc021qou.1	+	3	741	c.741G>A	c.(739-741)ccG>ccA	p.P247P		NM_001199206	NP_001186135	A6ND01	FOLR4_HUMAN	Homo sapiens folate receptor 4 (delta) homolog (mouse) (FOLR4), mRNA.	247						extracellular region	folic acid binding|receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14						TGTTCCTGCCGTTCCTTTCCT	0.617												
BCAT1	586	broad.mit.edu	37	12	25047326	25047326	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:25047326C>T	uc001rgd.4	-	2	689	c.162G>A	c.(160-162)acG>acA	p.T54T	BCAT1_uc001rgc.3_Silent_p.T53T|BCAT1_uc010six.2_Silent_p.T66T|BCAT1_uc010siy.2_Silent_p.T54T|BCAT1_uc001rge.4_Silent_p.T30T	NM_005504	NP_005495	P54687	BCAT1_HUMAN	Homo sapiens branched chain amino-acid transaminase 1, cytosolic (BCAT1), transcript variant 1, mRNA.	54					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			breast(1)|large_intestine(1)|lung(3)|prostate(2)	7	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	GCATATGATCCGTGAACACAG	0.453												
CIT	11113	broad.mit.edu	37	12	120142198	120142198	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:120142198G>A	uc001txj.2	-	40	5330	c.5274C>T	c.(5272-5274)aaC>aaT	p.N1758N	CIT_uc001txh.2_Silent_p.N1235N|CIT_uc001txi.2_Silent_p.N1716N	NM_001206999	NP_001193928	O14578	CTRO_HUMAN	Homo sapiens citron (rho-interacting, serine/threonine kinase 21) (CIT), transcript variant 1, mRNA.	1716	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGAGGTTTTCGTTGTAGCGGA	0.512												
AACS	65985	broad.mit.edu	37	12	125621257	125621257	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:125621257C>T	uc001uhc.3	+	16	1934	c.1728C>T	c.(1726-1728)aaC>aaT	p.N576N	AACS_uc001uhd.3_Intron|AACS_uc009zyh.3_Non-coding_Transcript|AACS_uc009zyi.3_Silent_p.N174N	NM_023928	NP_076417	Q86V21	AACS_HUMAN	Homo sapiens acetoacetyl-CoA synthetase (AACS), mRNA.	576					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		CCCAGTATAACAAGTACAGGG	0.597												
GALNT9	50614	broad.mit.edu	37	12	132688129	132688129	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:132688129C>T	uc001ukc.4	-	6	1300	c.1184G>A	c.(1183-1185)cGc>cAc	p.R395H	GALNT9_uc009zyr.3_Missense_Mutation_p.R169H|GALNT9_uc001ukb.3_Missense_Mutation_p.R252H|GALNT9_uc001uka.3_Missense_Mutation_p.R29H	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9) (GALNT9), transcript variant A, mRNA.	395					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(1)|large_intestine(2)|lung(5)	9	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		CAGGGCGTTGCGCTTGGCATA	0.637												
HTR2A	3356	broad.mit.edu	37	13	47466570	47466570	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr13:47466570T>C	uc010acr.3	-	2	1257	c.568A>G	c.(568-570)Act>Gct	p.T190A	HTR2A_uc001vbr.3_Missense_Mutation_p.T106A	NM_000621	NP_000612	P28223	5HT2A_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A), transcript variant 1, mRNA.	190					ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AATGCCTTAGTTCTGGAGTTG	0.493												
DIS3	22894	broad.mit.edu	37	13	73355005	73355005	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr13:73355005G>A	uc001vix.4	-	1	739	c.365C>T	c.(364-366)aCt>aTt	p.T122I	PIBF1_uc010aeo.1_5'Flank|PIBF1_uc001vjb.3_5'Flank|PIBF1_uc001vjc.3_5'Flank|PIBF1_uc010aep.3_5'Flank|DIS3_uc001viy.4_Intron|DIS3_uc001viz.3_Non-coding_Transcript	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	Homo sapiens DIS3 mitotic control homolog (S. cerevisiae) (DIS3), transcript variant 1, mRNA.	122	PINc.				CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		ATTAGTGAAAGTATAGAAATG	0.388										Multiple Myeloma(4;0.011)		
KIAA0430	9665	broad.mit.edu	37	16	15692768	15692768	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:15692768C>T	uc002ddr.3	-	25	5134	c.4927G>A	c.(4927-4929)Gtt>Att	p.V1643I	KIAA0430_uc002ddq.3_Missense_Mutation_p.V1477I|KIAA0430_uc010uzv.2_Missense_Mutation_p.V1640I|KIAA0430_uc010uzw.2_Missense_Mutation_p.V1643I	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	Homo sapiens KIAA0430 (KIAA0430), transcript variant 1, mRNA.	1642						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TGGAGGATAACGGGGTCTGGT	0.592												
VPS35	55737	broad.mit.edu	37	16	46694426	46694426	+	Silent	SNP	T	T	G			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:46694426T>G	uc002eef.4	-	16	2448	c.2349A>C	c.(2347-2349)tcA>tcC	p.S783S	VPS35_uc002eed.3_3'UTR|VPS35_uc002eee.3_Silent_p.S744S	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA.	783					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CGGATTCTGGTGATTCCCGCC	0.438												
ABCC11	85320	broad.mit.edu	37	16	48247385	48247385	+	Missense_Mutation	SNP	G	G	A	rs148839428		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:48247385G>A	uc002eff.1	-	8	1675	c.1325C>T	c.(1324-1326)aCg>aTg	p.T442M	ABCC11_uc002efg.1_Missense_Mutation_p.T442M|ABCC11_uc002efh.1_Missense_Mutation_p.T442M|ABCC11_uc010vgk.1_Non-coding_Transcript	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (ABCC11), transcript variant 2, mRNA.	442	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CTTGGAATTCGTGAGACCTTT	0.552												
CNGB1	1258	broad.mit.edu	37	16	57993926	57993926	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:57993926G>A	uc002emt.2	-	9	692	c.627C>T	c.(625-627)gcC>gcT	p.A209A	CNGB1_uc010cdh.2_Silent_p.A203A|CNGB1_uc002emu.2_Silent_p.A209A	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	Homo sapiens cyclic nucleotide gated channel beta 1 (CNGB1), transcript variant 1, mRNA.	209	Pro-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GGGTCTCCCGGGCCTGCAGCT	0.687												
SMTNL2	342527	broad.mit.edu	37	17	4496362	4496362	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr17:4496362G>A	uc002fyf.1	+	2	693	c.626G>A	c.(625-627)gGg>gAg	p.G209E	SMTNL2_uc002fye.2_Missense_Mutation_p.G65E	NM_001114974	NP_940903	Q2TAL5	SMTL2_HUMAN	Homo sapiens smoothelin-like 2 (SMTNL2), transcript variant 1, mRNA.	209										breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		AGGTTCTCTGGGGAGACCTCA	0.657												
TMEM220	388335	broad.mit.edu	37	17	10628403	10628403	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr17:10628403G>A	uc002gmx.3	-	3	690	c.212C>T	c.(211-213)aCg>aTg	p.T71M	TMEM220_uc002gmy.3_Missense_Mutation_p.T61M	NM_001004313	NP_001004313	Q6QAJ8	TM220_HUMAN	Homo sapiens transmembrane protein 220 (TMEM220), mRNA.	71						integral to membrane		p.T71M(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(2)	5						AGCCCACACCGTACAAAAGAG	0.448												
HAP1	9001	broad.mit.edu	37	17	39884047	39884047	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr17:39884047C>T	uc002hxm.1	-	7	1254	c.1242G>A	c.(1240-1242)tcG>tcA	p.S414S	JUP_uc010wfs.2_Intron|HAP1_uc002hxn.1_Silent_p.S414S|HAP1_uc002hxo.1_Intron|HAP1_uc002hxp.1_Intron	NM_177977	NP_817084	P54257	HAP1_HUMAN	Homo sapiens huntingtin-associated protein 1 (HAP1), transcript variant 2, mRNA.	414	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TTTCCTTCTCCGAAGCCAGCT	0.622												
MUC16	94025	broad.mit.edu	37	19	9071728	9071728	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:9071728T>C	uc002mkp.3	-	2	15922	c.15718A>G	c.(15718-15720)Aag>Gag	p.K5240E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	5242	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.D5239N(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTGTGGACTTATCATGGTCT	0.478												
CD22	933	broad.mit.edu	37	19	35832284	35832285	+	Frame_Shift_Ins	INS	-	-	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:35832284_35832285insT	uc010edt.3	+	7	1630_1631	c.1546_1547insT	c.(1546-1548)cttfs	p.L516fs	CD22_uc010edu.3_Frame_Shift_Ins_p.L428fs|CD22_uc010edv.3_Frame_Shift_Ins_p.L516fs|CD22_uc002nzb.4_Frame_Shift_Ins_p.L339fs|CD22_uc010xst.2_Frame_Shift_Ins_p.L344fs|CD22_uc010edx.3_Non-coding_Transcript	NM_001771	NP_001762	P20273	CD22_HUMAN	Homo sapiens CD22 molecule (CD22), transcript variant 1, mRNA.	516	Ig-like C2-type 5.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AATCAAGCCCCTTTCCGAGATT	0.574												
GLTSCR2	29997	broad.mit.edu	37	19	48259848	48259848	+	Nonsense_Mutation	SNP	C	C	T	rs141718194		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:48259848C>T	uc002phm.2	+	10	1384	c.1360C>T	c.(1360-1362)Cga>Tga	p.R454*	GLTSCR2_uc010elk.1_Non-coding_Transcript	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	Homo sapiens glioma tumor suppressor candidate region gene 2 (GLTSCR2), mRNA.	454				EGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFR EIQL -> RGQHSFETGSRAFRGGI (in Ref. 3; AAG30413).|PEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAF REIQ -> VLTVSCRGAPCPVMTPSLLPVPPRGYGRHHGCP WAGPVGPMPRG (in Ref. 5).		nucleolus				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	15		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		GATCGAGCCTCGAGAGAGAGC	0.632												
NLRP12	91662	broad.mit.edu	37	19	54304629	54304629	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:54304629C>T	uc002qcj.4	-	6	2831	c.2611G>A	c.(2611-2613)Gct>Act	p.A871T	NLRP12_uc010eqw.3_Missense_Mutation_p.A153T|NLRP12_uc002qch.4_Missense_Mutation_p.A870T|NLRP12_uc002qci.4_Missense_Mutation_p.A870T|NLRP12_uc002qck.4_Intron|NLRP12_uc010eqx.3_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	Homo sapiens NLR family, pyrin domain containing 12 (NLRP12), transcript variant 2, mRNA.	870					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAGGCAGCAGCAGTGAGGCGG	0.493												
SMEK2	57223	broad.mit.edu	37	2	55791468	55791468	+	Silent	SNP	C	C	T	rs145292231		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr2:55791468C>T	uc002rzc.3	-	14	2933	c.2241G>A	c.(2239-2241)aaG>aaA	p.K747K	SMEK2_uc002rzb.3_Silent_p.K662K|SMEK2_uc002rzd.3_Silent_p.K715K|SMEK2_uc002ryz.3_Silent_p.K174K|SMEK2_uc002rza.3_Silent_p.K531K	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	Homo sapiens SMEK homolog 2, suppressor of mek1 (Dictyostelium) (SMEK2), transcript variant 1, mRNA.	747						microtubule organizing center|nucleus	protein binding			kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCTCCATAAACTTTTCATAAT	0.333												
TTN	7273	broad.mit.edu	37	2	179594120	179594120	+	Missense_Mutation	SNP	T	T	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr2:179594120T>A	uc021vsy.1	-	60	15256	c.15031A>T	c.(15031-15033)Aac>Tac	p.N5011Y	TTN_uc021vsz.1_Intron|TTN_uc021vta.1_Intron|TTN_uc021vtb.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N1672Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	5938	Ig-like 30.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATGGAGGTTAAACACAGAC	0.463												
INPP5D	3635	broad.mit.edu	37	2	233944058	233944058	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr2:233944058G>A	uc010zmo.2	+	1	301	c.148G>A	c.(148-150)Gtt>Att	p.V50I	INPP5D_uc010zmp.2_Missense_Mutation_p.V50I	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 1, mRNA.	50	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCGGAATTGCGTTTACACTTA	0.403												
NCOR1P1	149934	broad.mit.edu	37	20	26094557	26094557	+	Silent	SNP	A	A	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr20:26094557A>C	uc002wvj.4	-	0	121	c.66T>G	c.(64-66)ccT>ccG	p.P22P						Homo sapiens nuclear receptor corepressor 1 pseudogene 1 (NCOR1P1), non-coding RNA.																		TTACAGAGTGAGGAGGATAAT	0.418												
WFDC13	164237	broad.mit.edu	37	20	44334525	44334525	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr20:44334525T>C	uc002xpd.3	+	2	371	c.263T>C	c.(262-264)gTc>gCc	p.V88A	WFDC10B_uc002xpb.3_5'Flank|WFDC10B_uc002xpc.3_5'Flank	NM_172005	NP_742002	Q8IUB5	WFD13_HUMAN	Homo sapiens WAP four-disulfide core domain 13 (WFDC13), mRNA.	88						extracellular region	peptidase inhibitor activity			skin(1)|upper_aerodigestive_tract(1)	2		Myeloproliferative disorder(115;0.0122)				GGCTCAGAAGTCATCATGCCT	0.353												
LRRC3B	116135	broad.mit.edu	37	3	26751911	26751911	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:26751911G>A	uc003cdp.3	+	1	1337	c.748G>A	c.(748-750)Gat>Aat	p.D250N	LRRC3B_uc003cdq.3_Missense_Mutation_p.D250N|LRRC3B_uc021wuj.1_Missense_Mutation_p.D250N	NM_052953	NP_443185	Q96PB8	LRC3B_HUMAN	Homo sapiens leucine rich repeat containing 3B (LRRC3B), mRNA.	250						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						GAAGAAAGCAGATGAACCTGA	0.418												
AZI2	64343	broad.mit.edu	37	3	28381958	28381958	+	Nonsense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:28381958G>A	uc003ceb.3	-	1	683	c.151C>T	c.(151-153)Cga>Tga	p.R51*	AZI2_uc003cec.3_5'UTR|AZI2_uc003cee.4_Nonsense_Mutation_p.R51*|AZI2_uc011axd.1_Nonsense_Mutation_p.R51*|AZI2_uc003ceg.2_Nonsense_Mutation_p.R51*	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	Homo sapiens 5-azacytidine induced 2 (AZI2), transcript variant 1, mRNA.	51						mitochondrion|plasma membrane		p.K50K(2)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15						TCCTTAAGTCGTTTTTTGATG	0.338												
IMPG2	50939	broad.mit.edu	37	3	100951684	100951684	+	Silent	SNP	A	A	G			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:100951684A>G	uc003duq.2	-	14	3377	c.3174T>C	c.(3172-3174)ccT>ccC	p.P1058P	IMPG2_uc011bhe.2_Silent_p.P921P|IMPG2_uc010hpj.1_Non-coding_Transcript	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	Homo sapiens interphotoreceptor matrix proteoglycan 2 (IMPG2), mRNA.	1058	EGF-like 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AGCAGAAGTCAGGCTGTAGGT	0.488												
DZIP3	9666	broad.mit.edu	37	3	108353719	108353719	+	Missense_Mutation	SNP	G	G	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:108353719G>T	uc003dxd.3	+	10	1239	c.817_splice	c.e10-1	p.G273_splice	DZIP3_uc003dxf.1_Splice_Site_p.G273_splice|DZIP3_uc011bhm.2_Intron|DZIP3_uc003dxe.1_Splice_Site_p.G273_splice|DZIP3_uc003dxg.1_Splice_Site	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	Homo sapiens DAZ interacting protein 3, zinc finger (DZIP3), mRNA.	273					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TTTTTCCAGGGATTTTTTCAG	0.254												
COL6A5	256076	broad.mit.edu	37	3	130159044	130159044	+	Silent	SNP	T	T	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:130159044T>C	uc010htj.1	+	34	6356	c.5862T>C	c.(5860-5862)gcT>gcC	p.A1954A	COL6A5_uc010hti.1_Non-coding_Transcript|COL6A5_uc021xdz.1_5'UTR|COL6A5_uc010htk.1_5'UTR	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	Homo sapiens collagen, type VI, alpha 5 (COL6A5), mRNA.	1954	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						TTCGAGAGGCTTTCTTACCTG	0.403												
CEP70	80321	broad.mit.edu	37	3	138289888	138289888	+	Missense_Mutation	SNP	T	T	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:138289888T>C	uc003esl.3	-	4	470	c.272A>G	c.(271-273)aAt>aGt	p.N91S	CEP70_uc011bmk.2_Missense_Mutation_p.N71S|CEP70_uc011bml.2_Missense_Mutation_p.N73S|CEP70_uc011bmm.2_Intron|CEP70_uc003esm.3_Missense_Mutation_p.N91S|CEP70_uc003esn.3_Missense_Mutation_p.N91S	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	Homo sapiens centrosomal protein 70kDa (CEP70), mRNA.	91					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						AAGCTGTTGATTAGTTTCTAT	0.318												
PHC3	80012	broad.mit.edu	37	3	169840418	169840418	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:169840418C>T	uc003fgl.2	-	8	1937	c.1903G>A	c.(1903-1905)Ggg>Agg	p.G635R	PHC3_uc010hws.1_Missense_Mutation_p.G623R|PHC3_uc011bpq.1_Missense_Mutation_p.G582R	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	Homo sapiens polyhomeotic homolog 3 (Drosophila) (PHC3), mRNA.	623	Pro-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TCTCCTCTCCCCACTGTTATA	0.393												
FNDC3B	64778	broad.mit.edu	37	3	172096143	172096143	+	Missense_Mutation	SNP	A	A	G			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:172096143A>G	uc003fhy.3	+	23	3264	c.3092A>G	c.(3091-3093)cAg>cGg	p.Q1031R	FNDC3B_uc003fhz.4_Missense_Mutation_p.Q1031R	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	Homo sapiens fibronectin type III domain containing 3B (FNDC3B), transcript variant 1, mRNA.	1031	Fibronectin type-III 8.					endoplasmic reticulum|integral to membrane		p.Q1031H(1)		breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TTCAGAATCCAGGCAGCAAGC	0.493												
SH3TC1	54436	broad.mit.edu	37	4	8229589	8229589	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr4:8229589C>T	uc003gkv.4	+	11	2269	c.2168C>T	c.(2167-2169)cCc>cTc	p.P723L	SH3TC1_uc003gkw.4_Missense_Mutation_p.P647L|SH3TC1_uc003gkx.4_Non-coding_Transcript|SH3TC1_uc003gky.3_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	Homo sapiens SH3 domain and tetratricopeptide repeats 1 (SH3TC1), mRNA.	723							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						AAGTGCCTGCCCCACCTGGTG	0.657												
DRD5	1816	broad.mit.edu	37	4	9784937	9784937	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr4:9784937C>T	uc003gmb.4	+	0	1680	c.1284C>T	c.(1282-1284)gaC>gaT	p.D428D		NM_000798	NP_000789	P21918	DRD5_HUMAN	Homo sapiens dopamine receptor D5 (DRD5), mRNA.	428					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.D428D(2)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TGGACAACGACGAGGAGGAGG	0.582												
KIAA1211	57482	broad.mit.edu	37	4	57181748	57181748	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr4:57181748G>A	uc003hbk.2	+	7	2471	c.2080G>A	c.(2080-2082)Ggt>Agt	p.G694S	KIAA1211_uc010iha.2_Missense_Mutation_p.G687S|KIAA1211_uc011bzz.1_Missense_Mutation_p.G604S|KIAA1211_uc003hbm.1_Missense_Mutation_p.G580S	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	Homo sapiens KIAA1211 (KIAA1211), mRNA.	694										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GTTGAGGCCCGGTGATGAGTC	0.602												
OTUD4	54726	broad.mit.edu	37	4	146077118	146077118	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr4:146077118C>T	uc003ika.4	-	7	603	c.465G>A	c.(463-465)gtG>gtA	p.V155V		NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	Homo sapiens OTU domain containing 4 (OTUD4), transcript variant 3, mRNA.	220	OTU.						protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					TAAATCCATTCACATCAGCAG	0.328												
EFNA5	1946	broad.mit.edu	37	5	106762936	106762936	+	Nonsense_Mutation	SNP	G	G	A	rs142282920		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr5:106762936G>A	uc003kol.3	-	1	682	c.400C>T	c.(400-402)Cga>Tga	p.R134*	EFNA5_uc010jbr.1_Nonsense_Mutation_p.R134*	NM_001962	NP_001953	P52803	EFNA5_HUMAN	Homo sapiens ephrin-A5 (EFNA5), mRNA.	134					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding			large_intestine(6)	6		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		AAATATTCTCGGCCTGGCCTG	0.428												
TBC1D9B	23061	broad.mit.edu	37	5	179315134	179315134	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr5:179315134C>T	uc003mlh.3	-	6	1258	c.1223G>A	c.(1222-1224)aGg>aAg	p.R408K	TBC1D9B_uc003mli.3_Missense_Mutation_p.R408K|TBC1D9B_uc003mlj.3_Missense_Mutation_p.R408K	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	Homo sapiens TBC1 domain family, member 9B (with GRAM domain) (TBC1D9B), transcript variant 1, mRNA.	408						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTGGCTTTCCTGCTCCCGAT	0.567												
KHDRBS2	202559	broad.mit.edu	37	6	62604633	62604633	+	Silent	SNP	T	T	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr6:62604633T>A	uc003peg.2	-	5	964	c.717A>T	c.(715-717)gcA>gcT	p.A239A		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	Homo sapiens KH domain containing, RNA binding, signal transduction associated 2 (KHDRBS2), mRNA.	239	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		GGACACCTCTTGCTACAGGTG	0.607												
GPR85	54329	broad.mit.edu	37	7	112724285	112724288	+	Frame_Shift_Del	DEL	TGAG	TGAG	-			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr7:112724285_112724288delTGAG	uc010ljv.2	-	1	1006_1009	c.489_492delCTCA	c.(487-492)tactcafs	p.Y163fs	GPR85_uc003vgp.1_Frame_Shift_Del_p.Y163fs|GPR85_uc003vgq.2_Frame_Shift_Del_p.Y163fs|GPR85_uc010ljw.1_Frame_Shift_Del_p.Y163fs|GPR85_uc022akd.1_Frame_Shift_Del_p.Y163fs	NM_001146266	NP_061843	P60893	GPR85_HUMAN	Homo sapiens G protein-coupled receptor 85 (GPR85), transcript variant 3, mRNA.	163						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						CCCTAATGAATGAGTAAGTGCCCA	0.500												
GIMAP6	474344	broad.mit.edu	37	7	150325381	150325381	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr7:150325381G>A	uc022apv.1	-	2	995	c.515C>T	c.(514-516)cCc>cTc	p.P172L	GIMAP6_uc003whn.3_Missense_Mutation_p.P102L|GIMAP6_uc003whm.3_Intron	NM_001244072	NP_001231001	Q6P9H5	GIMA6_HUMAN	Homo sapiens GTPase, IMAP family member 6 (GIMAP6), transcript variant 2, mRNA.	102							GTP binding	p.G171S(1)		endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGAGACCTGGGGGGACAGAAT	0.622												
ABP1	26	broad.mit.edu	37	7	150554420	150554420	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr7:150554420C>T	uc003why.1	+	2	5080	c.862C>T	c.(862-864)Cgc>Tgc	p.R288C	ABP1_uc003whz.1_Missense_Mutation_p.R288C|ABP1_uc003wia.1_Missense_Mutation_p.R288C	NM_001091	NP_001082	P19801	ABP1_HUMAN	Homo sapiens amiloride binding protein 1 (amine oxidase (copper-containing)) (ABP1), mRNA.	288					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(3)|prostate(2)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CCACAAGCCCCGCGGGGACTT	0.697												
CPA6	57094	broad.mit.edu	37	8	68419124	68419124	+	Splice_Site	SNP	C	C	G			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr8:68419124C>G	uc003xxq.4	-	6	791	c.535_splice	c.e6-1	p.L179_splice	CPA6_uc003xxr.4_Splice_Site_p.L31_splice|CPA6_uc003xxs.2_Splice_Site_p.L179_splice	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	Homo sapiens carboxypeptidase A6 (CPA6), mRNA.	179					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GTCTGCCCAGCTGAAAACAAG	0.408												
CDH17	1015	broad.mit.edu	37	8	95189845	95189845	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr8:95189845G>A	uc003ygh.2	-	3	380	c.255C>T	c.(253-255)gaC>gaT	p.D85D	CDH17_uc011lgo.1_Silent_p.D85D|CDH17_uc011lgp.1_Silent_p.D85D	NM_004063	NP_004054	Q12864	CAD17_HUMAN	Homo sapiens cadherin 17, LI cadherin (liver-intestine) (CDH17), transcript variant 1, mRNA.	85	Cadherin 1.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTGTTTCCCTGTCCAAGGCTC	0.458												
NFIB	4781	broad.mit.edu	37	9	14307244	14307244	+	Silent	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:14307244C>T	uc022bdo.1	-	1	841	c.306G>A	c.(304-306)ccG>ccA	p.P102P	NFIB_uc003zlf.3_Silent_p.P102P|NFIB_uc003zle.3_Silent_p.P102P|NFIB_uc022bdp.1_Silent_p.P128P|NFIB_uc011lmo.2_Silent_p.P102P	NM_001190737	NP_001177666	O00712	NFIB_HUMAN	Homo sapiens nuclear factor I/B (NFIB), transcript variant 1, mRNA.	102					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		AGACACAGCACGGGTGCTTCT	0.527			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""							
SHB	6461	broad.mit.edu	37	9	37948668	37948668	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:37948668C>T	uc004aax.3	-	4	1878	c.1310G>A	c.(1309-1311)aGc>aAc	p.S437N		NM_003028	NP_003019	Q15464	SHB_HUMAN	Homo sapiens Src homology 2 domain containing adaptor protein B (SHB), mRNA.	437	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCTGGTCTGGCTGTTCCGGAC	0.647												
ALDOB	229	broad.mit.edu	37	9	104187273	104187273	+	Missense_Mutation	SNP	A	A	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:104187273A>T	uc004bbk.2	-	7	933	c.851T>A	c.(850-852)cTc>cAc	p.L284H		NM_000035	NP_000026	P05062	ALDOB_HUMAN	Homo sapiens aldolase B, fructose-bisphosphate (ALDOB), mRNA.	284			L -> P (in HFI).		fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				GATAGCATTGAGGTTGAGAGT	0.517												
PTGS1	5742	broad.mit.edu	37	9	125146014	125146014	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:125146014C>T	uc004bmg.1	+	7	1124	c.989C>T	c.(988-990)aCg>aTg	p.T330M	PTGS1_uc011lys.1_Missense_Mutation_p.T305M|PTGS1_uc010mwb.1_Missense_Mutation_p.T221M|PTGS1_uc004bmf.1_Missense_Mutation_p.T330M|PTGS1_uc004bmh.1_Missense_Mutation_p.T221M|PTGS1_uc011lyt.1_Missense_Mutation_p.T221M	NM_000962	NP_000953	P23219	PGH1_HUMAN	Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1), transcript variant 1, mRNA.	330					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CTTTTCCAGACGACCCGCCTC	0.607												
COQ4	51117	broad.mit.edu	37	9	131088069	131088069	+	Missense_Mutation	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:131088069G>A	uc004bur.4	+	3	658	c.311G>A	c.(310-312)cGg>cAg	p.R104Q	COQ4_uc011max.1_Missense_Mutation_p.R104Q|COQ4_uc010mxy.3_Missense_Mutation_p.R80Q	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	Homo sapiens coenzyme Q4 homolog (S. cerevisiae) (COQ4), nuclear gene encoding mitochondrial protein, mRNA.	104					ubiquinone biosynthetic process	mitochondrial inner membrane				endometrium(4)|large_intestine(1)|lung(4)	9						GAGCGTCCCCGGATTTCGACA	0.587												
KLHL15	80311	broad.mit.edu	37	X	24006559	24006559	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:24006559C>T	uc004dba.4	-	3	1550	c.1294G>A	c.(1294-1296)Ggt>Agt	p.G432S		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	Homo sapiens kelch-like 15 (Drosophila) (KLHL15), mRNA.	432										autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						GTGATTCCACCGGTGATAAAC	0.443												
FGD1	2245	broad.mit.edu	37	X	54496521	54496521	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:54496521G>A	uc004dtg.3	-	3	1763	c.1029C>T	c.(1027-1029)gaC>gaT	p.D343D	FGD1_uc011moi.1_Silent_p.D101D	NM_004463	NP_004454	P98174	FGD1_HUMAN	Homo sapiens FYVE, RhoGEF and PH domain containing 1 (FGD1), mRNA.	343					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						cctcctcgtcgtcctcctcct	0.627												
ZMYM3	9203	broad.mit.edu	37	X	70467290	70467290	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:70467290C>T	uc004dzh.2	-	12	2398	c.2219G>A	c.(2218-2220)cGt>cAt	p.R740H	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.2_Missense_Mutation_p.R740H|ZMYM3_uc004dzj.2_Missense_Mutation_p.R740H	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	Homo sapiens zinc finger, MYM-type 3 (ZMYM3), transcript variant 1, mRNA.	740					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					GCAGAAATGACGGATCTGCCC	0.582												
CAPN6	827	broad.mit.edu	37	X	110494147	110494147	+	Missense_Mutation	SNP	G	G	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:110494147G>T	uc004epc.2	-	7	1347	c.1156C>A	c.(1156-1158)Cag>Aag	p.Q386K	CAPN6_uc011msu.2_Missense_Mutation_p.Q131K	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	Homo sapiens calpain 6 (CAPN6), mRNA.	386	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding	p.Q386K(2)		cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						ACTCAAACCTGGGGATTCTGC	0.453												
DDX26B	203522	broad.mit.edu	37	X	134714081	134714081	+	Missense_Mutation	SNP	G	G	C			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:134714081G>C	uc004eyw.4	+	14	2740	c.2377G>C	c.(2377-2379)Ggt>Cgt	p.G793R	DDX26B_uc004eyx.4_Missense_Mutation_p.G394R	NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B (DDX26B), mRNA.	793										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					TCGAAAGTTTGGTCGAAGTAA	0.373												
GPR101	83550	broad.mit.edu	37	X	136113330	136113330	+	Silent	SNP	G	G	A			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:136113330G>A	uc011mwh.2	-	0	504	c.504C>T	c.(502-504)taC>taT	p.Y168Y		NM_054021	NP_473362	Q96P66	GP101_HUMAN	Homo sapiens G protein-coupled receptor 101 (GPR101), mRNA.	168						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					GGCCCCAGCCGTAGAGTGGAG	0.607												
SOX3	6658	broad.mit.edu	37	X	139587063	139587063	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:139587063C>T	uc004fbd.1	-	0	163	c.163G>A	c.(163-165)Gct>Act	p.A55T		NM_005634	NP_005625	P41225	SOX3_HUMAN	Homo sapiens SRY (sex determining region Y)-box 3 (SOX3), mRNA.	55					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	10	Acute lymphoblastic leukemia(192;7.65e-05)					GGGGCTGGAGCGGCCACGGTG	0.667												
SLITRK2	84631	broad.mit.edu	37	X	144906039	144906039	+	Missense_Mutation	SNP	C	C	T			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:144906039C>T	uc022cfn.1	+	0	2096	c.2096C>T	c.(2095-2097)cCc>cTc	p.P699L	SLITRK2_uc004fcd.3_Missense_Mutation_p.P699L|SLITRK2_uc010nsp.3_Missense_Mutation_p.P699L|SLITRK2_uc010nso.3_Missense_Mutation_p.P699L|SLITRK2_uc011mwq.2_Missense_Mutation_p.P699L|SLITRK2_uc011mwr.2_Missense_Mutation_p.P699L|SLITRK2_uc011mws.2_Missense_Mutation_p.P699L|SLITRK2_uc004fcg.3_Missense_Mutation_p.P699L|SLITRK2_uc011mwt.2_Missense_Mutation_p.P699L|CXorf1_uc004fch.3_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	Homo sapiens SLIT and NTRK-like family, member 2 (SLITRK2), transcript variant 1, mRNA.	699						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCAAAACCCCATCTACATG	0.478												
GPR50	9248	broad.mit.edu	37	X	150348278	150348278	+	Missense_Mutation	SNP	A	A	G			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:150348278A>G	uc010ntg.2	+	1	361	c.223A>G	c.(223-225)Atg>Gtg	p.M75V	GPR50_uc011myc.2_Missense_Mutation_p.M75V	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	Homo sapiens G protein-coupled receptor 50 (GPR50), mRNA.	75					cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					TGTGGCCGATATGCTGGTGGC	0.507