Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MXRA8	54587	broad.mit.edu	37	1	1290234	1290234	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:1290234G>C	uc001aew.2	-	5	808	c.777C>G	c.(775-777)ATC>ATG	p.I259M	MXRA8_uc001aex.3_Missense_Mutation_p.I259M|MXRA8_uc001aey.3_Missense_Mutation_p.I259M|MXRA8_uc010nyl.1_Missense_Mutation_p.I259M|MXRA8_uc001aez.2_Missense_Mutation_p.I158M|MXRA8_uc001afa.2_Missense_Mutation_p.I250M	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	259	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCAGCGGCTCGATACGCAGTG	0.687		NA											9	30					0	0	0	0
ATAD3B	83858	broad.mit.edu	37	1	1417591	1417591	+	Silent	SNP	C	C	T	rs143801965		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:1417591C>T	uc001afv.2	+	6	689	c.588C>T	c.(586-588)CGC>CGT	p.R196R	ATAD3B_uc001afw.2_Silent_p.R150R|ATAD3B_uc001afx.2_Silent_p.R150R	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	196	Potential.						ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCGGGCGCGCGCCAAGGCCG	0.662		NA											22	21					0	0	0	0
GNB1	2782	broad.mit.edu	37	1	1721851	1721851	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:1721851C>T	uc001aif.2	-	9	1014	c.682G>A	c.(682-684)GAC>AAC	p.D228N	GNB1_uc009vky.2_Missense_Mutation_p.D128N	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	228	WD 5.				cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GCATTGATGTCAGACTCGTGG	0.532		NA											6	93					0	0	0	0
MEGF6	1953	broad.mit.edu	37	1	3427384	3427384	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:3427384G>A	uc001akl.2	-	10	1424	c.1197C>T	c.(1195-1197)GCC>GCT	p.A399A	MEGF6_uc001akk.2_Silent_p.A294A	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	399	EGF-like 7.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCGGTAGCCGGCGTAGCAGC	0.672		NA											30	41					0	0	0	0
AADACL4	343066	broad.mit.edu	37	1	12726206	12726206	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:12726206C>G	uc001auf.2	+	4	684	c.684C>G	c.(682-684)TTC>TTG	p.F228L		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	228	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TCCAGGCATTCTGTTTGCAGT	0.527		NA											102	177					0	0	0	0
EPHA2	1969	broad.mit.edu	37	1	16461683	16461683	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:16461683C>G	uc001aya.1	-	7	1567	c.1430G>C	c.(1429-1431)GGA>GCA	p.G477A		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	477	Extracellular (Potential).|Fibronectin type-III 2.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GTTGGAGTCTCCCTGTGGGTG	0.677		NA											66	144					0	0	0	0
EPHA2	1969	broad.mit.edu	37	1	16464404	16464404	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:16464404G>C	uc001aya.1	-	5	1393	c.1256C>G	c.(1255-1257)TCA>TGA	p.S419*	EPHA2_uc010oca.1_Nonsense_Mutation_p.S419*	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	419	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TACCAGGCCTGAGACGCCATT	0.637		NA											17	79					0	0	0	0
EPHA2	1969	broad.mit.edu	37	1	16475323	16475323	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:16475323C>T	uc001aya.1	-	3	510	c.373G>A	c.(373-375)GAG>AAG	p.E125K	EPHA2_uc010oca.1_Missense_Mutation_p.E125K	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	125	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	AGGTCCGACTCGGCATAGTAG	0.547		NA											31	60					0	0	0	0
CROCC	9696	broad.mit.edu	37	1	17264170	17264170	+	Missense_Mutation	SNP	G	G	C	rs141704732		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:17264170G>C	uc001azt.2	+	10	1297	c.1228G>C	c.(1228-1230)GAG>CAG	p.E410Q	CROCC_uc009voy.1_Missense_Mutation_p.E113Q|CROCC_uc009voz.1_Missense_Mutation_p.E173Q|CROCC_uc001azu.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	410	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GAAGCGTCTTGAGAAGCAGAA	0.572		NA											6	18					0	0	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	18023375	18023375	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:18023375G>A	uc001ban.2	+	29	3499	c.3340G>A	c.(3340-3342)GGG>AGG	p.G1114R	ARHGEF10L_uc001bao.2_Missense_Mutation_p.G1075R|ARHGEF10L_uc001bap.2_Missense_Mutation_p.G1070R|ARHGEF10L_uc001baq.2_Missense_Mutation_p.G875R|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.G887R|ARHGEF10L_uc001bar.2_Missense_Mutation_p.G817R|ARHGEF10L_uc009vpf.2_RNA|ARHGEF10L_uc001bas.2_Missense_Mutation_p.G138R	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1114					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CGGGCACTGTGGGCCTGTGGC	0.627		NA									OREG0013156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	32					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19407997	19407997	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:19407997C>G	uc001bbi.2	-	103	15083	c.15079G>C	c.(15079-15081)GAG>CAG	p.E5027Q	UBR4_uc001bbf.2_5'UTR|UBR4_uc010ocv.1_Missense_Mutation_p.E550Q|UBR4_uc009vph.2_Missense_Mutation_p.E661Q|UBR4_uc010ocw.1_Missense_Mutation_p.E691Q|UBR4_uc001bbg.2_Missense_Mutation_p.E738Q|UBR4_uc001bbh.2_Missense_Mutation_p.E736Q	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	5027					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AAGGCACTCTCCACCCACTTC	0.517		NA											92	195					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19446699	19446699	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:19446699G>A	uc001bbi.2	-	69	10289	c.10285C>T	c.(10285-10287)CAC>TAC	p.H3429Y	UBR4_uc001bbj.1_5'Flank	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3429					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTCAGACAGTGGGCCTGCCAG	0.512		NA											13	108					0	0	0	0
NUDC	10726	broad.mit.edu	37	1	27272172	27272172	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:27272172G>A	uc001bng.1	+	8	1055	c.939G>A	c.(937-939)CTG>CTA	p.L313L	NUDC_uc001bnh.1_Silent_p.L370L|NUDC_uc009vsq.1_Silent_p.L287L	NM_006600	NP_006591	Q9Y266	NUDC_HUMAN	nuclear distribution gene C homolog	313					cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)		AGGAGATTCTGAAGAAGTGAG	0.547		NA											8	124					0	0	0	0
AHDC1	27245	broad.mit.edu	37	1	27877465	27877465	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:27877465C>T	uc009vsy.2	-	6	2131	c.1162G>A	c.(1162-1164)GAT>AAT	p.D388N	AHDC1_uc009vsz.1_Missense_Mutation_p.D388N|AHDC1_uc001boh.1_Missense_Mutation_p.D261N	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	388	Pro-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		TTTGGCCTATCAGTGCGCCGC	0.716		NA											6	15					0	0	0	0
C1orf38	9473	broad.mit.edu	37	1	28211959	28211959	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:28211959C>G	uc001bpc.3	+	5	1901	c.1873C>G	c.(1873-1875)CTA>GTA	p.L625V	C1orf38_uc001boz.2_3'UTR|C1orf38_uc001bpa.2_3'UTR|C1orf38_uc010ofn.1_Missense_Mutation_p.L429V|C1orf38_uc010ofo.1_Missense_Mutation_p.L496V	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	625					cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGCAGGATCTAGGTGAGTC	0.597		NA											11	29					0	0	0	0
BSDC1	55108	broad.mit.edu	37	1	32841914	32841914	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:32841914C>G	uc001bvh.3	-	9	1152	c.1105G>C	c.(1105-1107)GAG>CAG	p.E369Q	BSDC1_uc010ohg.1_Missense_Mutation_p.E386Q|BSDC1_uc010ohh.1_Missense_Mutation_p.E313Q|BSDC1_uc010ohi.1_Missense_Mutation_p.E274Q|BSDC1_uc001bvg.3_RNA|BSDC1_uc001bvj.2_Missense_Mutation_p.E265Q|BSDC1_uc001bvi.2_Missense_Mutation_p.E386Q	NM_018045	NP_060515	Q9NW68	BSDC1_HUMAN	BSD domain containing 1 isoform b	369							protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GAGTTCAGCTCAAACACCCGT	0.617		NA											47	121					0	0	0	0
KIAA1522	57648	broad.mit.edu	37	1	33234274	33234274	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:33234274G>A	uc001bvv.2	+	4	443	c.307G>A	c.(307-309)GAA>AAA	p.E103K	KIAA1522_uc001bvu.1_Missense_Mutation_p.E162K|KIAA1522_uc010ohm.1_Missense_Mutation_p.E114K|KIAA1522_uc010ohn.1_Missense_Mutation_p.E103K	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	103											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GGGGCCGGATGAAGACAACAT	0.532		NA											11	49					0	0	0	0
KIAA1522	57648	broad.mit.edu	37	1	33234319	33234319	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:33234319G>C	uc001bvv.2	+	4	488	c.352G>C	c.(352-354)GAG>CAG	p.E118Q	KIAA1522_uc001bvu.1_Missense_Mutation_p.E177Q|KIAA1522_uc010ohm.1_Missense_Mutation_p.E129Q|KIAA1522_uc010ohn.1_Missense_Mutation_p.E118Q	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	118											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTACGTGGCTGAGAGCTCCAC	0.602		NA											5	30					0	0	0	0
DLGAP3	58512	broad.mit.edu	37	1	35334493	35334493	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:35334493G>A	uc001byc.2	-	7	2198	c.2198C>T	c.(2197-2199)ACG>ATG	p.T733M		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	733					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CTGGCCCTGCGTGTGGACCGT	0.592		NA											12	12					0	0	0	0
NCDN	23154	broad.mit.edu	37	1	36024783	36024783	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:36024783G>A	uc001bza.2	+	3	236	c.109G>A	c.(109-111)GAG>AAG	p.E37K	KIAA0319L_uc001byx.2_5'Flank|KIAA0319L_uc010ohw.1_5'Flank|KIAA0319L_uc001byz.2_5'Flank|KIAA0319L_uc010ohx.1_5'Flank|NCDN_uc001bzb.2_Missense_Mutation_p.E37K|NCDN_uc001bzc.2_Missense_Mutation_p.E20K	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	37					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCCCACCCTGGAGCGCTACCT	0.597		NA											21	78					0	0	0	0
EIF2C3	192669	broad.mit.edu	37	1	36506033	36506033	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:36506033G>C	uc001bzp.2	+	16	2419	c.2163G>C	c.(2161-2163)AGG>AGC	p.R721S	EIF2C3_uc001bzq.2_Missense_Mutation_p.R487S	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	721	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGCTGATAGGACAGAAAGGG	0.413		NA											26	75					0	0	0	0
MUTYH	4595	broad.mit.edu	37	1	45796983	45796983	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:45796983G>C	uc001cnm.2	-	14	1554	c.1338C>G	c.(1336-1338)ATC>ATG	p.I446M	MUTYH_uc009vxn.2_Missense_Mutation_p.I271M|MUTYH_uc001cnf.2_Missense_Mutation_p.I421M|MUTYH_uc009vxo.2_Missense_Mutation_p.I421M|MUTYH_uc001cng.2_Missense_Mutation_p.I432M|MUTYH_uc001cnj.2_Missense_Mutation_p.I329M|MUTYH_uc001cni.2_Missense_Mutation_p.I421M|MUTYH_uc001cnh.2_Missense_Mutation_p.I422M|MUTYH_uc001cno.2_Missense_Mutation_p.I329M|MUTYH_uc001cnk.2_Missense_Mutation_p.I306M|MUTYH_uc010oll.1_Missense_Mutation_p.I130M|MUTYH_uc001cnl.2_Missense_Mutation_p.I435M|MUTYH_uc009vxp.2_Missense_Mutation_p.I449M|MUTYH_uc001cnn.2_Missense_Mutation_p.I436M	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	446	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					ATGTCAGCTTGATGTGAGAGA	0.537		NA	Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				11	58					0	0	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515108	47515108	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:47515108G>C	uc001cqt.2	+	11	1537	c.1287G>C	c.(1285-1287)TTG>TTC	p.L429F	CYP4X1_uc001cqr.2_Missense_Mutation_p.L428F|CYP4X1_uc001cqs.2_Missense_Mutation_p.L364F	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	429						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						TTGACCCCTTGAGGTTCTCTC	0.423		NA											36	95					0	0	0	0
SGIP1	84251	broad.mit.edu	37	1	67155939	67155939	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:67155939G>A	uc001dcr.2	+	17	1727	c.1510G>A	c.(1510-1512)GAA>AAA	p.E504K	SGIP1_uc010opd.1_Missense_Mutation_p.E104K|SGIP1_uc001dcs.2_Missense_Mutation_p.E104K|SGIP1_uc001dct.2_Missense_Mutation_p.E104K|SGIP1_uc009wat.2_Missense_Mutation_p.E298K	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	504					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						AGCGCGGGCTGAAAGCACTTC	0.453		NA											55	140					0	0	0	0
C1orf141	400757	broad.mit.edu	37	1	67558949	67558949	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:67558949G>C	uc001ddl.1	-	7	1053	c.942C>G	c.(940-942)CTC>CTG	p.L314L	C1orf141_uc001ddm.1_Silent_p.L314L|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	314										ovary(1)	1						AGAAATTATAGAGTGTATTCC	0.343		NA											31	98					0	0	0	0
LRRC7	57554	broad.mit.edu	37	1	70505167	70505167	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:70505167G>C	uc001dep.2	+	19	3576	c.3546G>C	c.(3544-3546)GTG>GTC	p.V1182V	LRRC7_uc009wbg.2_Silent_p.V466V|LRRC7_uc001deq.2_Silent_p.V423V	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1182						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ATCAAGAAGTGAAAGCTCAGG	0.502		NA											15	53					0	0	0	0
USP33	23032	broad.mit.edu	37	1	78163136	78163136	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:78163136C>T	uc001dht.2	-	25	3042	c.2695G>A	c.(2695-2697)GAA>AAA	p.E899K	USP33_uc009wca.1_RNA|USP33_uc001dhs.2_3'UTR|USP33_uc001dhu.2_Missense_Mutation_p.E868K	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	899	DUSP 2.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						CATGTTTCTTCAGAAATCTGG	0.388		NA											35	114					0	0	0	0
LRRC8C	84230	broad.mit.edu	37	1	90178699	90178699	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:90178699G>C	uc001dnl.3	+	3	812	c.570G>C	c.(568-570)AAG>AAC	p.K190N		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	190						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		ACAACAGGAAGAACAACATGA	0.453		NA											17	78					0	0	0	0
ABCA4	24	broad.mit.edu	37	1	94528713	94528713	+	Missense_Mutation	SNP	C	C	T	rs61748559		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:94528713C>T	uc001dqh.2	-	12	1819	c.1715G>A	c.(1714-1716)CGA>CAA	p.R572Q	ABCA4_uc010otn.1_Missense_Mutation_p.R572Q	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	572	Extracellular.		R -> P (in STGD1).|R -> Q (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TATGTCCATTCGGATCTTATA	0.473		NA											58	148					0	0	0	0
WDR77	79084	broad.mit.edu	37	1	111990152	111990152	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:111990152G>A	uc001ebb.2	-	3	387	c.348C>T	c.(346-348)GTC>GTT	p.V116V	WDR77_uc010owd.1_Intron|WDR77_uc010owe.1_Intron|ATP5F1_uc009wgf.1_5'Flank|ATP5F1_uc001ebc.2_5'Flank|ATP5F1_uc001ebd.3_5'Flank	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	116	WD 1.				ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGAACTTGCTGACAATAAGTG	0.453		NA											11	40					0	0	0	0
DDX20	11218	broad.mit.edu	37	1	112303904	112303904	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:112303904C>T	uc001ebs.2	+	7	1376	c.1019C>T	c.(1018-1020)TCA>TTA	p.S340L	DDX20_uc010owf.1_Missense_Mutation_p.S102L|DDX20_uc001ebt.2_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	340	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGTGCATTTCAGGTAAGTTC	0.338		NA											11	78					0	0	0	0
PDZK1	5174	broad.mit.edu	37	1	145761230	145761230	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:145761230C>A	uc001eon.1	+	8	1140	c.1043C>A	c.(1042-1044)TCT>TAT	p.S348Y	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Missense_Mutation_p.S348Y|PDZK1_uc010oza.1_Missense_Mutation_p.S237Y	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	348					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CCCAATGGCTCTGTCAAGGAG	0.423		NA											22	67					7.04e-22	7.57e-22	1	0
HIST2H3D	653604	broad.mit.edu	37	1	149784945	149784945	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:149784945C>T	uc010pbl.1	-	1	292	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	98					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						AGGTAGGCCTCGCTGGCCTCC	0.642		NA											14	50					0	0	0	0
RFX5	5993	broad.mit.edu	37	1	151317305	151317305	+	Silent	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:151317305C>A	uc001exv.1	-	6	466	c.252G>T	c.(250-252)CTG>CTT	p.L84L	RFX5_uc001exw.1_Silent_p.L84L|RFX5_uc009wmr.1_Silent_p.L84L|RFX5_uc010pcx.1_Intron	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	84	N-terminal domain.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTCATTGCTCAGTGTACTTG	0.463		NA											8	59					7.48e-07	7.79e-07	1	0
TCHH	7062	broad.mit.edu	37	1	152079998	152079998	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:152079998C>T	uc001ezp.2	-	2	5695	c.5695G>A	c.(5695-5697)GGG>AGG	p.G1899R	TCHH_uc009wne.1_Missense_Mutation_p.G1899R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1899					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTATCTCCCCGACTTGGCGG	0.582		NA											27	105					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152282518	152282518	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:152282518G>A	uc001ezu.1	-	3	4880	c.4844C>T	c.(4843-4845)TCC>TTC	p.S1615F		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1615	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTTTCTGGAAGCCGACTC	0.572		NA							Ichthyosis				57	147					0	0	0	0
KPRP	448834	broad.mit.edu	37	1	152733229	152733229	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:152733229G>C	uc001fal.1	+	2	1223	c.1165G>C	c.(1165-1167)GAC>CAC	p.D389H		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	389	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACGGCGTCTTGACCAGTGTCC	0.647		NA											15	31					0	0	0	0
S100A2	6273	broad.mit.edu	37	1	153533966	153533966	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:153533966G>A	uc001fcb.2	-	3	581	c.243C>T	c.(241-243)CTC>CTT	p.L81L		NM_005978	NP_005969	P29034	S10A2_HUMAN	S100 calcium binding protein A2	82	EF-hand 2.				endothelial cell migration		calcium ion binding			ovary(1)	1	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGACAGTGATGAGTGCCAGGA	0.542		NA											4	184					0	0	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154988249	154988249	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:154988249G>C	uc001fgk.3	+	3	1271	c.1113G>C	c.(1111-1113)GAG>GAC	p.E371D	ZBTB7B_uc009wpa.2_Missense_Mutation_p.E371D|ZBTB7B_uc001fgj.3_Missense_Mutation_p.E405D|ZBTB7B_uc010peq.1_Missense_Mutation_p.E405D|ZBTB7B_uc001fgl.3_Missense_Mutation_p.E371D	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	371					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACACAGGCGAGAAGCCCTTTG	0.647		NA											10	52					0	0	0	0
ADAM15	8751	broad.mit.edu	37	1	155026830	155026830	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:155026830G>C	uc001fgr.1	+	6	561	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	ADAM15_uc001fgq.1_5'UTR|ADAM15_uc009wpc.1_RNA|ADAM15_uc010pet.1_Missense_Mutation_p.E138Q|ADAM15_uc010peu.1_Missense_Mutation_p.E171Q|ADAM15_uc001fgt.1_Missense_Mutation_p.E154Q|ADAM15_uc010pev.1_Missense_Mutation_p.E164Q|ADAM15_uc001fgs.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgu.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgw.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgv.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgx.1_Missense_Mutation_p.E154Q|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	154					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CTATACCCTGGAGCAGGGGCC	0.547		NA											24	87					0	0	0	0
FDPS	2224	broad.mit.edu	37	1	155279943	155279943	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:155279943G>A	uc001fkc.2	+	3	505	c.286G>A	c.(286-288)GAG>AAG	p.E96K	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.E30K|FDPS_uc001fke.2_Missense_Mutation_p.E96K|FDPS_uc001fkf.2_Missense_Mutation_p.E30K	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	96					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	GGTGCTGACTGAGGATGAGAT	0.512		NA											18	64					0	0	0	0
YY1AP1	55249	broad.mit.edu	37	1	155629559	155629559	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:155629559C>T	uc001fln.2	-	11	2304	c.2280G>A	c.(2278-2280)CCG>CCA	p.P760P	YY1AP1_uc001flg.2_Silent_p.P499P|YY1AP1_uc010pgg.1_Silent_p.P599P|YY1AP1_uc010pgh.1_Silent_p.P703P|YY1AP1_uc010pgi.1_Silent_p.P852P|YY1AP1_uc001flh.2_Silent_p.P832P|YY1AP1_uc009wqt.2_Silent_p.P683P|YY1AP1_uc001flk.2_Silent_p.P703P|YY1AP1_uc001fll.2_Silent_p.P714P|YY1AP1_uc009wqv.2_Silent_p.P431P|YY1AP1_uc001flm.2_Silent_p.P703P|YY1AP1_uc001fli.2_Silent_p.P714P|YY1AP1_uc009wqu.2_Silent_p.P547P|YY1AP1_uc001flj.2_Silent_p.P694P|YY1AP1_uc009wqw.2_Silent_p.P683P|YY1AP1_uc001flo.2_Silent_p.P648P|YY1AP1_uc001flp.2_Silent_p.P714P	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	760					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CCTGAGGGAGCGGCTCCAGAG	0.512		NA											25	105					0	0	0	0
IFI16	3428	broad.mit.edu	37	1	159015213	159015213	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:159015213C>T	uc010pis.1	+	7	1467	c.1288C>T	c.(1288-1290)CAG>TAG	p.Q430*	IFI16_uc001ftg.2_Intron|IFI16_uc001fth.2_Intron|IFI16_uc010pit.1_Nonsense_Mutation_p.Q85*	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	486					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					CCACACTCCTCAGATGCCTCC	0.483		NA											12	136					0	0	0	0
LMX1A	4009	broad.mit.edu	37	1	165322354	165322354	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:165322354G>A	uc001gcy.1	-	2	443	c.222C>T	c.(220-222)TTC>TTT	p.F74F	LMX1A_uc001gcz.1_Silent_p.F74F	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	74	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					TGTCCCGGTAGAAGCAGGTGG	0.602		NA											16	91					0	0	0	0
DNM3	26052	broad.mit.edu	37	1	172348233	172348233	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:172348233C>T	uc001gie.2	+	18	2145	c.1969C>T	c.(1969-1971)CGC>TGC	p.R657C	DNM3_uc001gif.2_Missense_Mutation_p.R653C|DNM3_uc001gih.1_Missense_Mutation_p.R13C	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	663	GED.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						GGAGACCATTCGCAACCTCGT	0.383		NA											7	35					0	0	0	0
TNN	63923	broad.mit.edu	37	1	175048789	175048789	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:175048789G>C	uc001gkl.1	+	3	843	c.730G>C	c.(730-732)GAC>CAC	p.D244H	TNN_uc010pmx.1_Missense_Mutation_p.D244H	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	244	EGF-like 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGGCTTCTGTGACACGGGCGA	0.662		NA											3	15					0	0	0	0
SOAT1	6646	broad.mit.edu	37	1	179311320	179311320	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:179311320G>C	uc001gml.2	+	8	915	c.852G>C	c.(850-852)GAG>GAC	p.E284D	SOAT1_uc010pni.1_Missense_Mutation_p.E219D|SOAT1_uc001gmm.2_Missense_Mutation_p.E226D|SOAT1_uc010pnj.1_Missense_Mutation_p.E20D|SOAT1_uc010pnk.1_Missense_Mutation_p.E219D	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	284					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	CAGCTAAGGAGAAATCAAGTA	0.254		NA											9	40					0	0	0	0
CEP350	9857	broad.mit.edu	37	1	180080147	180080147	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:180080147G>C	uc001gnt.2	+	38	9588	c.9205G>C	c.(9205-9207)GAG>CAG	p.E3069Q	CEP350_uc009wxl.2_Missense_Mutation_p.E3068Q|CEP350_uc001gnv.2_Missense_Mutation_p.E1204Q|CEP350_uc001gnw.1_Missense_Mutation_p.E826Q|CEP350_uc001gnx.1_Missense_Mutation_p.E826Q	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	3069						centrosome|nucleus|spindle				ovary(4)	4						GGAGCTCCATGAGGAGGAGGC	0.413		NA											14	71					0	0	0	0
NCF2	4688	broad.mit.edu	37	1	183543724	183543724	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:183543724C>G	uc001gqj.3	-	4	674	c.399G>C	c.(397-399)AAG>AAC	p.K133N	NCF2_uc010pod.1_Intron|NCF2_uc010poe.1_Intron|NCF2_uc001gqk.3_Missense_Mutation_p.K133N	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	133	TPR 3.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						ATTCCTCCTTCTTGGCATACA	0.438		NA											27	79					0	0	0	0
FAM129A	116496	broad.mit.edu	37	1	184787891	184787891	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:184787891C>G	uc001gra.2	-	9	1248	c.1054G>C	c.(1054-1056)GAG>CAG	p.E352Q	FAM129A_uc001grb.1_Missense_Mutation_p.E115Q|FAM129A_uc009wyh.1_Missense_Mutation_p.E180Q|FAM129A_uc009wyi.1_Missense_Mutation_p.E150Q	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	352					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						ATGAGCTCCTCCAGGATGGAT	0.527		NA											28	189					0	0	0	0
KCNT2	343450	broad.mit.edu	37	1	196395022	196395022	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:196395022G>C	uc001gtd.1	-	11	1141	c.1081C>G	c.(1081-1083)CAA>GAA	p.Q361E	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.Q361E|KCNT2_uc001gtf.1_Missense_Mutation_p.Q361E|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.Q361E|KCNT2_uc009wyv.1_Missense_Mutation_p.Q336E	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	361	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GCTGAACCTTGAAGGTAGATA	0.403		NA											29	59					0	0	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200801916	200801916	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:200801916G>A	uc001gvl.2	+	7	1173	c.903G>A	c.(901-903)TTG>TTA	p.L301L	CAMSAP1L1_uc001gvk.2_Silent_p.L290L|CAMSAP1L1_uc001gvm.2_Silent_p.L290L	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	301	CH.					cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						AAGAATACTTGAACCAGTGTT	0.323		NA											19	74					0	0	0	0
IRF6	3664	broad.mit.edu	37	1	209969798	209969798	+	Missense_Mutation	SNP	C	C	G	rs121434224		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:209969798C>G	uc001hhq.1	-	4	537	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	IRF6_uc010psm.1_5'UTR|IRF6_uc009xct.1_Missense_Mutation_p.E92Q	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	92	IRF tryptophan pentad repeat.				cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		AGGTTGAATTCTCTGCTCTTA	0.532		NA								HNSCC(57;0.16)			21	41					0	0	0	0
TATDN3	128387	broad.mit.edu	37	1	212977943	212977943	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:212977943T>C	uc001hjo.2	+	7	531	c.437T>C	c.(436-438)GTG>GCG	p.V146A	TATDN3_uc010ptj.1_Missense_Mutation_p.V146A|TATDN3_uc010ptk.1_Missense_Mutation_p.V146A|TATDN3_uc001hjp.2_Missense_Mutation_p.V146A|TATDN3_uc010ptl.1_Missense_Mutation_p.V125A|TATDN3_uc010ptm.1_Missense_Mutation_p.V94A	NM_001042552	NP_001036017	Q17R31	TATD3_HUMAN	TatD DNase domain containing 3 isoform 1	146						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)		AACAGAAATGTGCACTCACGC	0.338		NA											6	39					0	0	0	0
C1orf124	83932	broad.mit.edu	37	1	231489093	231489093	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:231489093G>A	uc001hur.2	+	5	1904	c.1456G>A	c.(1456-1458)GAA>AAA	p.E486K	C1orf124_uc001hus.2_3'UTR|C1orf124_uc001hut.2_3'UTR	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	486					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AGTCAAAAGCGAAGAAAGTCT	0.403		NA											4	34					0	0	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232649741	232649741	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:232649741G>A	uc001hvg.2	-	1	1503	c.1345C>T	c.(1345-1347)CAC>TAC	p.H449Y		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	449					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTTGTGCAGTGAGAGCTGAGT	0.522		NA											46	142					0	0	0	0
OR2L3	391192	broad.mit.edu	37	1	248224207	248224207	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:248224207C>G	uc001idx.1	+	1	224	c.224C>G	c.(223-225)ACC>AGC	p.T75S	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TACATCTCCACCATTGTTCCT	0.438		NA											48	274					0	0	0	0
PGBD2	267002	broad.mit.edu	37	1	249211312	249211312	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr1:249211312C>T	uc001ifh.2	+	3	676	c.529C>T	c.(529-531)CAG>TAG	p.Q177*	PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Nonsense_Mutation_p.Q174*	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	177										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCTTACGGCTCAGGAATTGAA	0.368		NA											20	120					0	0	0	0
DIP2C	22982	broad.mit.edu	37	10	436786	436786	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:436786C>G	uc001ifp.2	-	11	1368	c.1278G>C	c.(1276-1278)CAG>CAC	p.Q426H	DIP2C_uc009xhj.1_Missense_Mutation_p.Q122H	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	426						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AGAAACCTATCTGCTGGCTCC	0.562		NA											34	121					0	0	0	0
NET1	10276	broad.mit.edu	37	10	5495245	5495245	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:5495245C>T	uc001iia.2	+	7	765	c.627C>T	c.(625-627)ATC>ATT	p.I209I	NET1_uc010qar.1_Silent_p.I28I|NET1_uc001iib.2_Silent_p.I155I|NET1_uc010qas.1_Silent_p.I28I	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	209	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						AGTTGTCCATCATGTCAGAAG	0.408		NA											49	164					0	0	0	0
FBXO18	84893	broad.mit.edu	37	10	5951160	5951160	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:5951160C>T	uc001iis.2	+	5	1018	c.923C>T	c.(922-924)CCC>CTC	p.P308L	FBXO18_uc001iir.2_Missense_Mutation_p.P234L|FBXO18_uc009xig.2_Missense_Mutation_p.P234L|FBXO18_uc001iit.2_Missense_Mutation_p.P359L	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	308					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						AGTGTGGATCCCGAGAGGGTG	0.592		NA											19	67					0	0	0	0
ITIH2	3698	broad.mit.edu	37	10	7769773	7769773	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:7769773G>C	uc001ijs.2	+	11	1423	c.1261G>C	c.(1261-1263)GAT>CAT	p.D421H		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	421	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TTTGGTTTCTGATGGAGATCC	0.453		NA											15	47					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16957877	16957877	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:16957877G>A	uc001ioo.2	-	46	7205	c.7153C>T	c.(7153-7155)CAG>TAG	p.Q2385*		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2385	CUB 17.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAAGAATTCTGAAGGTTAAAG	0.413		NA											14	94					0	0	0	0
CACNB2	783	broad.mit.edu	37	10	18827162	18827162	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:18827162C>G	uc001ipr.2	+	13	1416	c.1356C>G	c.(1354-1356)CAC>CAG	p.H452Q	CACNB2_uc009xjz.1_Missense_Mutation_p.H202Q|CACNB2_uc001ips.2_Missense_Mutation_p.H428Q|CACNB2_uc001ipt.2_Missense_Mutation_p.H414Q|CACNB2_uc001ipu.2_Missense_Mutation_p.H424Q|CACNB2_uc001ipv.2_Missense_Mutation_p.H400Q|CACNB2_uc009xka.1_Missense_Mutation_p.H386Q|CACNB2_uc001ipw.2_Missense_Mutation_p.H359Q|CACNB2_uc001ipx.2_Missense_Mutation_p.H397Q|CACNB2_uc001ipz.2_Missense_Mutation_p.H374Q|CACNB2_uc001ipy.2_Missense_Mutation_p.H398Q|CACNB2_uc010qco.1_Missense_Mutation_p.H366Q|CACNB2_uc001iqa.2_Missense_Mutation_p.H404Q|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	452					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCTGTGAGCACCTTGCCGACT	0.552		NA											47	134					0	0	0	0
DNAJC1	64215	broad.mit.edu	37	10	22208791	22208791	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:22208791G>C	uc001irc.2	-	5	892	c.605C>G	c.(604-606)TCA>TGA	p.S202*	DNAJC1_uc001ird.2_Nonsense_Mutation_p.S88*	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	202	Cytoplasmic (By similarity).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				ACCGAGTTTTGATACATCCAC	0.299		NA											34	123					0	0	0	0
MYO3A	53904	broad.mit.edu	37	10	26286125	26286125	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:26286125G>C	uc001isn.2	+	6	806	c.446G>C	c.(445-447)AGA>ACA	p.R149T	MYO3A_uc009xko.1_Missense_Mutation_p.R149T|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.R149T|MYO3A_uc001ism.2_Missense_Mutation_p.R149T	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	149	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						ACTATCCACAGAGATGTGAAA	0.308		NA											20	61					0	0	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317643	30317643	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:30317643C>G	uc001iux.2	-	2	1493	c.1434G>C	c.(1432-1434)CAG>CAC	p.Q478H	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.Q340H|KIAA1462_uc009xle.1_Missense_Mutation_p.Q478H	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	478										ovary(4)	4						GTATTAAGCTCTGTGGATTCC	0.572		NA											43	124					0	0	0	0
CUL2	8453	broad.mit.edu	37	10	35327992	35327992	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:35327992C>G	uc001ixv.2	-	9	943	c.733G>C	c.(733-735)GAT>CAT	p.D245H	CUL2_uc009xma.2_Missense_Mutation_p.D114H|CUL2_uc010qer.1_Missense_Mutation_p.D264H|CUL2_uc001ixw.2_Missense_Mutation_p.D245H|CUL2_uc010qes.1_Missense_Mutation_p.D182H	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	245					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						ATTTCTTCATCTTTTAATCTA	0.323		NA											10	41					0	0	0	0
MAPK8	5599	broad.mit.edu	37	10	49618178	49618178	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:49618178C>G	uc009xnz.2	+	5	641	c.417C>G	c.(415-417)ATC>ATG	p.I139M	MAPK8_uc001jgl.2_Missense_Mutation_p.I139M|MAPK8_uc001jgm.2_Missense_Mutation_p.I139M|MAPK8_uc001jgo.2_Missense_Mutation_p.I139M|MAPK8_uc009xoa.2_Missense_Mutation_p.I139M|MAPK8_uc001jgn.2_Missense_Mutation_p.I139M|MAPK8_uc010qgk.1_Missense_Mutation_p.I139M|MAPK8_uc001jgp.2_Missense_Mutation_p.I139M|MAPK8_uc001jgq.2_Missense_Mutation_p.I139M	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	139	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		TGTGTGGAATCAAGCACCTTC	0.348		NA											3	145					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55782797	55782797	+	Missense_Mutation	SNP	C	C	G	rs146468805		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:55782797C>G	uc001jju.1	-	19	2776	c.2381G>C	c.(2380-2382)GGA>GCA	p.G794A	PCDH15_uc010qhq.1_Missense_Mutation_p.G799A|PCDH15_uc010qhr.1_Missense_Mutation_p.G794A|PCDH15_uc010qhs.1_Missense_Mutation_p.G806A|PCDH15_uc010qht.1_Missense_Mutation_p.G801A|PCDH15_uc010qhu.1_Missense_Mutation_p.G794A|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.G794A|PCDH15_uc010qhw.1_Missense_Mutation_p.G757A|PCDH15_uc010qhx.1_Missense_Mutation_p.G723A|PCDH15_uc010qhy.1_Missense_Mutation_p.G799A|PCDH15_uc010qhz.1_Missense_Mutation_p.G794A|PCDH15_uc010qia.1_Missense_Mutation_p.G772A|PCDH15_uc010qib.1_Missense_Mutation_p.G772A|PCDH15_uc001jjw.2_Missense_Mutation_p.G794A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	794	Extracellular (Potential).|Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GTGTACTGCTCCATCTGTTGC	0.423		NA								HNSCC(58;0.16)			27	99					0	0	0	0
USP54	159195	broad.mit.edu	37	10	75335391	75335391	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:75335391G>A	uc001juo.2	-	1	43	c.26C>T	c.(25-27)TCA>TTA	p.S9L	USP54_uc001jup.2_Missense_Mutation_p.S9L|USP54_uc010qkl.1_Missense_Mutation_p.S9L	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	9					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					ACGACCCCCTGAAAAATAATT	0.448		NA											18	105					0	0	0	0
MYST4	23522	broad.mit.edu	37	10	76789241	76789241	+	Silent	SNP	C	C	T	rs147158118		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:76789241C>T	uc001jwn.1	+	18	5152	c.4659C>T	c.(4657-4659)AGC>AGT	p.S1553S	MYST4_uc001jwo.1_Silent_p.S1261S|MYST4_uc001jwp.1_Silent_p.S1370S	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1553					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					AGGAGAGCAGCGAACAGGACG	0.527		NA	T	CREBBP	AML								15	110					0	0	0	0
TLL2	7093	broad.mit.edu	37	10	98146809	98146809	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:98146809G>C	uc001kml.1	-	14	1979	c.1753C>G	c.(1753-1755)CAC>GAC	p.H585D		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	585	EGF-like 1; calcium-binding (Potential).			EVDECSWPDHGGCEHRCV -> GKKKKKKKKKKKKKKKKK (in Ref. 5; AAH13871).	cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CACCCGCCGTGATCTGGCCAG	0.592		NA											18	48					0	0	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98362077	98362077	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:98362077C>G	uc001kmq.2	-	16	2448	c.2320G>C	c.(2320-2322)GAG>CAG	p.E774Q	PIK3AP1_uc001kmo.2_Missense_Mutation_p.E373Q|PIK3AP1_uc001kmp.2_Missense_Mutation_p.E596Q	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	774	Pro-rich.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GGGGGTCTCTCGAGGGACATG	0.507		NA											26	40					0	0	0	0
CRTAC1	55118	broad.mit.edu	37	10	99655057	99655057	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:99655057G>A	uc001kou.1	-	11	1787	c.1431C>T	c.(1429-1431)ATC>ATT	p.I477I	CRTAC1_uc001kov.2_Silent_p.I466I|CRTAC1_uc001kot.1_Silent_p.I267I	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	477						proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		AGCCCCCGTCGATGATCCTCA	0.632		NA											18	36					0	0	0	0
POLL	27343	broad.mit.edu	37	10	103344383	103344383	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:103344383G>T	uc001ktg.1	-	4	1633	c.867C>A	c.(865-867)TTC>TTA	p.F289L	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_5'Flank|POLL_uc001kte.1_5'Flank|POLL_uc001kth.1_Intron|POLL_uc001kti.1_Missense_Mutation_p.F289L|POLL_uc001ktj.1_Missense_Mutation_p.F289L|POLL_uc001ktf.2_Intron|POLL_uc001ktk.1_Intron|POLL_uc010qqa.1_Intron|POLL_uc010qqb.1_Intron|POLL_uc001ktm.2_Missense_Mutation_p.F289L|POLL_uc001ktl.2_Missense_Mutation_p.F201L|POLL_uc010qqc.1_Intron|POLL_uc010qqd.1_Missense_Mutation_p.S147Y	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	289					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CAGGCTTATGGAAGCTCTTGA	0.562		NA						DNA_polymerases_(catalytic_subunits)					14	51					1.05e-09	1.11e-09	1	0
CCDC147	159686	broad.mit.edu	37	10	106152107	106152107	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:106152107G>C	uc001kyh.2	+	10	1616	c.1482G>C	c.(1480-1482)GTG>GTC	p.V494V		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	494	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATGAAGCTGTGAGATCAGACA	0.299		NA											22	117					0	0	0	0
ADRB1	153	broad.mit.edu	37	10	115804636	115804636	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:115804636C>T	uc001lba.2	+	1	831	c.745C>T	c.(745-747)CGC>TGC	p.R249C		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	249	Cytoplasmic (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	GCGGGTGTTCCGCGAGGCCCA	0.547		NA											10	22					0	0	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118354333	118354333	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:118354333G>C	uc001lco.1	+	5	440	c.422G>C	c.(421-423)CGA>CCA	p.R141P	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.R141P|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	141					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AACAACGTGCGAGTGGTGGGC	0.592		NA											10	62					0	0	0	0
PDZD8	118987	broad.mit.edu	37	10	119044202	119044202	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:119044202G>A	uc001lde.1	-	5	2241	c.2042C>T	c.(2041-2043)TCA>TTA	p.S681L		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	681					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		AATTTCTGATGATTCCCATGT	0.413		NA											12	100					0	0	0	0
TACC2	10579	broad.mit.edu	37	10	123976183	123976183	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:123976183C>G	uc001lfv.2	+	11	7746	c.7386C>G	c.(7384-7386)ATC>ATG	p.I2462M	TACC2_uc001lfw.2_Missense_Mutation_p.I608M|TACC2_uc009xzx.2_Missense_Mutation_p.I2417M|TACC2_uc010qtv.1_Missense_Mutation_p.I2466M|TACC2_uc001lfx.2_Missense_Mutation_p.I166M|TACC2_uc001lfy.2_Missense_Mutation_p.I162M|TACC2_uc001lfz.2_Missense_Mutation_p.I540M|TACC2_uc001lga.2_Missense_Mutation_p.I540M|TACC2_uc009xzy.2_Missense_Mutation_p.I552M|TACC2_uc001lgb.2_Missense_Mutation_p.I497M|TACC2_uc010qtw.1_Missense_Mutation_p.I557M	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2462						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CACCAGTGATCTCTGCGGTGG	0.537		NA											4	101					0	0	0	0
DOCK1	1793	broad.mit.edu	37	10	129207596	129207596	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:129207596G>A	uc001ljt.2	+	42	4285	c.4221G>A	c.(4219-4221)GTG>GTA	p.V1407V	DOCK1_uc010qun.1_Silent_p.V1428V|DOCK1_uc009yaq.2_Silent_p.V402V	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1407	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GCTTCACAGTGAAGCCCAAAC	0.493		NA											12	95					0	0	0	0
EBF3	253738	broad.mit.edu	37	10	131640406	131640406	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:131640406G>A	uc001lki.1	-	13	1378	c.1319C>T	c.(1318-1320)TCA>TTA	p.S440L		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	449					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TGACGTCTCTGACACGTTGAC	0.612		NA											35	92					0	0	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133946815	133946815	+	Splice_Site	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr10:133946815G>C	uc001lkx.3	+	3	634	c.634_splice	c.e3-1	p.M212_splice		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TCTCCTTGTAGATGGAGGAGA	0.537		NA											3	10					0	0	0	0
PTDSS2	81490	broad.mit.edu	37	11	479110	479110	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:479110G>C	uc001lpj.2	+	4	569	c.393G>C	c.(391-393)GTG>GTC	p.V131V	PTDSS2_uc009ybv.1_Silent_p.V131V	NM_030783	NP_110410	Q9BVG9	PTSS2_HUMAN	phosphatidylserine synthase 2	131	Helical; (Potential).					integral to membrane					0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)	GGCTCTGCGTGAGTGTGGTCT	0.567		NA											60	236					0	0	0	0
PHRF1	57661	broad.mit.edu	37	11	605232	605232	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:605232G>A	uc001lqe.2	+	11	1397	c.1266G>A	c.(1264-1266)CTG>CTA	p.L422L	PHRF1_uc010qwc.1_Silent_p.L422L|PHRF1_uc010qwd.1_Silent_p.L421L|PHRF1_uc010qwe.1_Silent_p.L418L|PHRF1_uc009ybz.1_Silent_p.L213L|PHRF1_uc009yca.1_5'Flank	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	422							RNA polymerase binding|zinc ion binding				0						TGGGGCTGCTGAGAGCGGATA	0.597		NA											33	95					0	0	0	0
PHLDA2	7262	broad.mit.edu	37	11	2950434	2950434	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:2950434G>C	uc001lxa.1	-	1	217	c.161C>G	c.(160-162)TCC>TGC	p.S54C		NM_003311	NP_003302	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain family A member	54	PH.				apoptosis	cytoplasm|membrane					0		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTGAGGATGGAGTGGAAGCG	0.657		NA											8	45					0	0	0	0
DCHS1	8642	broad.mit.edu	37	11	6662141	6662141	+	Missense_Mutation	SNP	C	C	T	rs143767864	byFrequency	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:6662141C>T	uc001mem.1	-	2	1114	c.704G>A	c.(703-705)CGG>CAG	p.R235Q		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	235	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGCCCTCCGGGGGGGTGA	0.587		NA											10	145					0	0	0	0
SBF2	81846	broad.mit.edu	37	11	9875240	9875240	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:9875240C>G	uc001mib.2	-	20	2521	c.2383G>C	c.(2383-2385)GAG>CAG	p.E795Q	SBF2_uc001mif.3_Missense_Mutation_p.E551Q|uc001mig.2_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	795					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TCATAGCTCTCAGCTACACTT	0.373		NA											18	142					0	0	0	0
MICAL2	9645	broad.mit.edu	37	11	12263802	12263802	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:12263802C>G	uc001mjz.2	+	19	2667	c.2379C>G	c.(2377-2379)CTC>CTG	p.L793L	MICAL2_uc010rch.1_Intron|MICAL2_uc001mka.2_Silent_p.L793L|MICAL2_uc010rci.1_Silent_p.L793L|MICAL2_uc001mkb.2_Intron|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Intron|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	793						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TCAGAGAGCTCAAGCAAGTGT	0.562		NA											10	29					0	0	0	0
BTBD10	84280	broad.mit.edu	37	11	13427228	13427228	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:13427228C>T	uc001mkz.2	-	7	1241	c.984G>A	c.(982-984)CAG>CAA	p.Q328Q	BTBD10_uc010rcl.1_Silent_p.Q336Q|BTBD10_uc001mla.2_Silent_p.Q312Q|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Silent_p.Q280Q|BTBD10_uc010rcn.1_Silent_p.Q297Q|BTBD10_uc009ygo.2_Silent_p.Q280Q	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	328						nucleus					0				Epithelial(150;0.0214)		CTTCTCCCATCTGTGGTGGAT	0.423		NA											50	147					0	0	0	0
COPB1	1315	broad.mit.edu	37	11	14520460	14520460	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:14520460C>G	uc001mli.2	-	2	322	c.15G>C	c.(13-15)GAG>GAC	p.E5D	COPB1_uc001mlg.2_Missense_Mutation_p.E5D|COPB1_uc001mlh.2_Missense_Mutation_p.E5D|PSMA1_uc010rcp.1_RNA	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	5					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						AGCATACGTTCTCAGCCGCCG	0.343		NA											12	40					0	0	0	0
PSMA1	5682	broad.mit.edu	37	11	14539457	14539457	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:14539457G>C	uc001mlk.2	-	3	265	c.119C>G	c.(118-120)TCA>TGA	p.S40*	PSMA1_uc001mll.2_Nonsense_Mutation_p.S46*|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Nonsense_Mutation_p.S15*|PSMA1_uc010rcq.1_Nonsense_Mutation_p.S40*	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	40					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						ATGAGTTTTTGATTTCAGACC	0.318		NA											18	37					0	0	0	0
NUCB2	4925	broad.mit.edu	37	11	17333590	17333590	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:17333590G>C	uc001mmw.2	+	10	1080	c.835G>C	c.(835-837)GAC>CAC	p.D279H	NUCB2_uc001mmv.1_Missense_Mutation_p.D279H|NUCB2_uc009ygz.2_Missense_Mutation_p.D279H	NM_005013	NP_005004	P80303	NUCB2_HUMAN	nucleobindin 2 precursor	279	Binds to necdin (By similarity).					cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding				0						GAAAGTATATGACCCTAAAAA	0.299		NA											10	133					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22281213	22281213	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:22281213C>T	uc001mqi.2	+	15	1873	c.1556C>T	c.(1555-1557)TCA>TTA	p.S519L	ANO5_uc001mqj.2_Missense_Mutation_p.S518L	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	519	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CTCACAGGATCATGCTTGAAC	0.378		NA											20	61					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22301235	22301235	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:22301235G>T	uc001mqi.2	+	22	2983	c.2666G>T	c.(2665-2667)GGA>GTA	p.G889V	ANO5_uc001mqj.2_Missense_Mutation_p.G888V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	889	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GAGAACTTGGGAATTAATTCT	0.363		NA											7	75					0.00198382	0.00203006	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137420	40137420	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:40137420A>T	uc001mxa.1	-	2	2387	c.423T>A	c.(421-423)AAT>AAA	p.N141K	LRRC4C_uc001mxc.1_Missense_Mutation_p.N137K|LRRC4C_uc001mxd.1_Missense_Mutation_p.N137K|LRRC4C_uc001mxb.1_Missense_Mutation_p.N137K	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	141	LRR 3.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CAAAAGCTCCATTCGGGATGG	0.428		NA											20	62					0	0	0	0
PHF21A	51317	broad.mit.edu	37	11	45975109	45975109	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:45975109G>T	uc001ncc.3	-	10	1685	c.1061C>A	c.(1060-1062)GCA>GAA	p.A354E	PHF21A_uc001ncb.3_Missense_Mutation_p.A355E|PHF21A_uc009ykx.2_Missense_Mutation_p.A355E|PHF21A_uc001nce.2_Missense_Mutation_p.A355E|PHF21A_uc001nca.1_Missense_Mutation_p.A90E	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	354					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						TGGTTTGGGTGCAGCAGGTGG	0.448		NA											6	51					1.13e-05	1.17e-05	1	0
LRP4	4038	broad.mit.edu	37	11	46897369	46897369	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:46897369C>T	uc001ndn.3	-	26	3831	c.3685G>A	c.(3685-3687)GAT>AAT	p.D1229N		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1229	Extracellular (Potential).|LDL-receptor class B 14.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GTGTGGGCATCGGCCCATAGC	0.597		NA											8	62					0	0	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409589	56409589	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:56409589G>T	uc001njb.1	-	1	327	c.327C>A	c.(325-327)TTC>TTA	p.F109L		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						AGGAGCCAAAGAAGTAGAACT	0.512		NA											17	41					0.006122	0.00624123	1	0
RTN4RL2	349667	broad.mit.edu	37	11	57235099	57235099	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:57235099C>G	uc010rjt.1	+	2	49	c.49C>G	c.(49-51)CTC>GTC	p.L17V		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	17					axon regeneration	anchored to plasma membrane	receptor activity				0						CTCGGCCTGCCTCCTGCTGAT	0.677		NA											32	105					0	0	0	0
OR5A1	219982	broad.mit.edu	37	11	59211187	59211187	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:59211187C>T	uc001nnx.1	+	1	546	c.546C>T	c.(544-546)TGC>TGT	p.C182C		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						ACTTCTTCTGCGACCTCCCAC	0.537		NA											73	251					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62286867	62286867	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:62286867C>G	uc001ntl.2	-	5	15322	c.15022G>C	c.(15022-15024)GAG>CAG	p.E5008Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5008					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAGGAGTCTCAAGGTTCAGC	0.423		NA											58	147					0	0	0	0
MACROD1	28992	broad.mit.edu	37	11	63767135	63767135	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:63767135C>T	uc001nyh.2	-	6	884	c.765G>A	c.(763-765)CTG>CTA	p.L255L		NM_014067	NP_054786	Q9BQ69	MACD1_HUMAN	MACRO domain containing 1	255	Macro.										0						GCCGGTGCTCCAGCAGCAGGT	0.716		NA											4	22					0	0	0	0
FERMT3	83706	broad.mit.edu	37	11	63974990	63974990	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:63974990C>G	uc001nyl.2	+	2	303	c.154C>G	c.(154-156)CAG>GAG	p.Q52E	FERMT3_uc001nym.2_Missense_Mutation_p.Q52E	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	52					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GATTGTGGAGCAGATCAGTGA	0.667		NA											11	61					0	0	0	0
BAD	572	broad.mit.edu	37	11	64037697	64037697	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64037697G>A	uc001nzd.2	-	4	573	c.491C>T	c.(490-492)TCC>TTC	p.S164F	BAD_uc001nzc.2_Missense_Mutation_p.S164F|GPR137_uc009ypj.1_5'UTR	NM_032989	NP_116784	Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	164					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)	1						GGAGGGGGCGGAGCTTCCCCT	0.637		NA											11	42					0	0	0	0
GPR137	56834	broad.mit.edu	37	11	64054131	64054131	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64054131C>G	uc001nzg.1	+	2	443	c.135C>G	c.(133-135)CTC>CTG	p.L45L	BAD_uc001nzd.2_5'Flank|BAD_uc001nzc.2_5'Flank|GPR137_uc009ypj.1_Silent_p.L51L|BAD_uc009ypk.2_5'Flank|GPR137_uc010rni.1_Silent_p.L103L|GPR137_uc001nze.1_Silent_p.L45L|GPR137_uc001nzf.2_Silent_p.L45L|GPR137_uc001nzh.1_Silent_p.L45L|GPR137_uc001nzi.2_Silent_p.L45L|GPR137_uc010rnj.1_Silent_p.L45L	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	45	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						ATGCCCAGCTCTGGCTGGTGC	0.627		NA											44	138					0	0	0	0
ESRRA	2101	broad.mit.edu	37	11	64082296	64082296	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64082296G>A	uc001nzq.1	+	5	832	c.655G>A	c.(655-657)GAT>AAT	p.D219N	ESRRA_uc001nzr.1_Missense_Mutation_p.D218N|ESRRA_uc001nzs.1_Missense_Mutation_p.D219N|ESRRA_uc009ypn.1_Intron	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	219	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						CGCAGGCCCTGATGGGCACCT	0.587		NA											12	59					0	0	0	0
RASGRP2	10235	broad.mit.edu	37	11	64510267	64510267	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64510267G>A	uc009ypu.2	-	2	299	c.72C>T	c.(70-72)TTC>TTT	p.F24F	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'Flank|RASGRP2_uc009ypv.2_Silent_p.F24F|RASGRP2_uc009ypw.2_Silent_p.F24F|RASGRP2_uc001oaw.1_Missense_Mutation_p.S327L	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	24	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						GCCACTCACCGAAGGCTTCGA	0.726		NA											4	18					0	0	0	0
ATG2A	23130	broad.mit.edu	37	11	64673226	64673226	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:64673226G>A	uc001obx.2	-	23	3474	c.3359C>T	c.(3358-3360)TCT>TTT	p.S1120F	ATG2A_uc001obw.2_5'Flank	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1120							protein binding			ovary(1)|central_nervous_system(1)	2						ATAGTCCACAGAGCAGGAGAA	0.632		NA											7	84					0	0	0	0
EFEMP2	30008	broad.mit.edu	37	11	65635368	65635368	+	Silent	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:65635368G>T	uc001ofy.3	-	10	1328	c.1134C>A	c.(1132-1134)ATC>ATA	p.I378I	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Silent_p.I378I	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	378					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		TTCCAGCACGGATCTGAAAGG	0.547		NA											33	116					2.68e-12	2.85e-12	1	0
TSGA10IP	254187	broad.mit.edu	37	11	65727397	65727397	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:65727397G>A	uc001ogk.1	+	10	1689	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_RNA|SART1_uc009yqy.1_5'Flank|SART1_uc010rot.1_5'Flank|SART1_uc001ogl.2_5'Flank	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	553											0						CCTGGACCCGGAGTGCAGTCC	0.562		NA											5	21					0	0	0	0
RBM4B	83759	broad.mit.edu	37	11	66436418	66436418	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:66436418G>C	uc001oja.2	-	2	1426	c.757C>G	c.(757-759)CAA>GAA	p.Q253E	RBM4B_uc001ojb.2_Missense_Mutation_p.Q253E	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	253	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						CTTTGGACTTGAGGCAGATGG	0.542		NA											4	158					0	0	0	0
RBM4B	83759	broad.mit.edu	37	11	66436492	66436492	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:66436492G>C	uc001oja.2	-	2	1352	c.683C>G	c.(682-684)TCT>TGT	p.S228C	RBM4B_uc001ojb.2_Missense_Mutation_p.S228C	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	228	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						TGCCTCATAAGAGCGGACCCG	0.537		NA											3	76					0	0	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68707045	68707045	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:68707045G>A	uc001ook.1	+	15	2930	c.2828G>A	c.(2827-2829)AGA>AAA	p.R943K	IGHMBP2_uc001ool.1_Missense_Mutation_p.R567K	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	943					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCCCGGCAGAGAATCAGCCGG	0.642		NA											16	60					0	0	0	0
PDE2A	5138	broad.mit.edu	37	11	72290599	72290599	+	Silent	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:72290599G>T	uc010rrc.1	-	26	2478	c.2235C>A	c.(2233-2235)ATC>ATA	p.I745I	PDE2A_uc001oso.2_Silent_p.I724I|PDE2A_uc010rra.1_Silent_p.I738I|PDE2A_uc001osn.2_Silent_p.I489I|PDE2A_uc010rrb.1_Silent_p.I736I|PDE2A_uc010rrd.1_Silent_p.I630I	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	745	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	AATGATCAAAGATGTTGCAGC	0.418		NA											14	70					4.75e-09	5e-09	1	0
ARHGEF17	9828	broad.mit.edu	37	11	73073674	73073674	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:73073674G>A	uc001otu.2	+	14	4912	c.4891G>A	c.(4891-4893)GAG>AAG	p.E1631K		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1631					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CCCCCGCCCAGAGCTGGTGCC	0.687		NA											17	35					0	0	0	0
MYO7A	4647	broad.mit.edu	37	11	76891443	76891443	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:76891443G>C	uc001oyb.2	+	22	2882	c.2610G>C	c.(2608-2610)GAG>GAC	p.E870D	MYO7A_uc010rsl.1_Missense_Mutation_p.E870D|MYO7A_uc010rsm.1_Missense_Mutation_p.E859D|MYO7A_uc001oyc.2_Missense_Mutation_p.E870D|MYO7A_uc001oyd.2_Missense_Mutation_p.E210D|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.E81D	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	870	Potential.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						TCGAGGCTGAGAAAATGCGGC	0.597		NA											12	23					0	0	0	0
BIRC3	330	broad.mit.edu	37	11	102195714	102195714	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:102195714G>A	uc001pgx.2	+	3	696	c.474G>A	c.(472-474)ATG>ATA	p.M158I		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	158					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		CTGCCTTGATGAGAAGTTCCT	0.408		NA	T	MALT1	MALT								60	147					0	0	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103047052	103047052	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:103047052G>C	uc001pho.2	+	37	5907	c.5763G>C	c.(5761-5763)CTG>CTC	p.L1921L	DYNC2H1_uc001phn.1_Silent_p.L1921L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1921					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTGATGCACTGATAAAAGATG	0.363		NA											5	18					0	0	0	0
CASP5	838	broad.mit.edu	37	11	104871152	104871152	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:104871152A>T	uc010rva.1	-	6	820	c.788T>A	c.(787-789)GTA>GAA	p.V263E	CASP5_uc010ruz.1_Missense_Mutation_p.V276E|CASP5_uc010rvb.1_Missense_Mutation_p.V205E|CASP5_uc010rvc.1_Missense_Mutation_p.V121E|CASP5_uc009yxh.2_Missense_Mutation_p.V45E|CASP5_uc010rvd.1_Missense_Mutation_p.V45E	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	263					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		AGACATGAGTACCAAGAACGT	0.458		NA											22	81					0	0	0	0
CUL5	8065	broad.mit.edu	37	11	107975080	107975080	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:107975080C>G	uc001pjv.2	+	19	2979	c.2312C>G	c.(2311-2313)TCT>TGT	p.S771C	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	771					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		AGAGATGAATCTGATATCAAC	0.308		NA											29	112					0	0	0	0
SIK3	23387	broad.mit.edu	37	11	116730297	116730297	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:116730297G>C	uc001ppy.2	-	19	2167	c.2131C>G	c.(2131-2133)CAA>GAA	p.Q711E	SIK3_uc001ppz.2_Missense_Mutation_p.Q610E|SIK3_uc001pqa.2_Missense_Mutation_p.Q711E|SIK3_uc001ppw.2_Missense_Mutation_p.Q128E|SIK3_uc001ppx.2_Missense_Mutation_p.Q149E|SIK3_uc001pqb.2_Missense_Mutation_p.Q14E	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	711	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						GGTAAGCCTTGAAACTGGGAA	0.537		NA									OREG0003491	type=REGULATORY REGION|Gene=AK022302|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	64					0	0	0	0
UBE4A	9354	broad.mit.edu	37	11	118239345	118239345	+	Splice_Site	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:118239345G>C	uc001psw.2	+	3	251	c.122_splice	c.e3-1	p.D41_splice	UBE4A_uc001psv.2_Splice_Site_p.D41_splice	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TTTTCTGGCAGATGAACTCCC	0.413		NA											87	249					0	0	0	0
TRAPPC4	51399	broad.mit.edu	37	11	118892481	118892481	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:118892481G>C	uc010ryo.1	+	4	731	c.466G>C	c.(466-468)GTG>CTG	p.V156L	TRAPPC4_uc010ryp.1_Missense_Mutation_p.V102L|TRAPPC4_uc001pup.2_RNA|TRAPPC4_uc010ryq.1_Intron	NM_016146	NP_057230	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4	156					dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		GATCAAGTTTGTGGTTCTAGC	0.338		NA											13	60					0	0	0	0
FAM118B	79607	broad.mit.edu	37	11	126110786	126110786	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:126110786C>G	uc001qdf.2	+	4	369	c.186C>G	c.(184-186)CTC>CTG	p.L62L	FAM118B_uc009zca.2_Silent_p.L66L|FAM118B_uc001qdg.2_Silent_p.L62L	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	62											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		TTCCAGCCCTCAAATCCTGGA	0.453		NA											74	256					0	0	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275461	130275461	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr11:130275461G>A	uc001qgg.3	-	9	3020	c.2662C>T	c.(2662-2664)CCC>TCC	p.P888S	ADAMTS8_uc001qgf.2_Missense_Mutation_p.P369S	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	888	TSP type-1 2.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		AATCACAGGGGGCACAGCTGG	0.637		NA											14	97					0	0	0	0
IQSEC3	440073	broad.mit.edu	37	12	278251	278251	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:278251C>T	uc001qhw.1	+	9	2141	c.2135C>T	c.(2134-2136)TCA>TTA	p.S712L	IQSEC3_uc001qhu.1_Missense_Mutation_p.S712L	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1015					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GACCCACAGTCAAAGCAAGGA	0.642		NA											32	64					0	0	0	0
VWF	7450	broad.mit.edu	37	12	6103292	6103292	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6103292G>A	uc001qnn.1	-	37	6584	c.6334C>T	c.(6334-6336)CAG>TAG	p.Q2112*	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2112	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GTCCATTCCTGAACAAGTGTT	0.542		NA											12	51					0	0	0	0
VWF	7450	broad.mit.edu	37	12	6103365	6103365	+	Silent	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6103365G>T	uc001qnn.1	-	37	6511	c.6261C>A	c.(6259-6261)ATC>ATA	p.I2087I	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2087	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TCTCATCACAGATCCCTAGAG	0.478		NA											14	42					2.62e-11	2.78e-11	1	0
SCNN1A	6337	broad.mit.edu	37	12	6457124	6457124	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6457124G>A	uc001qnx.2	-	13	2214	c.1925C>T	c.(1924-1926)CCT>CTT	p.P642L	SCNN1A_uc001qnv.2_Missense_Mutation_p.P342L|SCNN1A_uc001qnw.2_Missense_Mutation_p.P701L|SCNN1A_uc010sfb.1_Missense_Mutation_p.P665L	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	642	Cytoplasmic (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	ggcataggcagggggaggggc	0.244		NA											4	9					0	0	0	0
LAG3	3902	broad.mit.edu	37	12	6887472	6887472	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:6887472G>C	uc001qqt.3	+	8	1843	c.1494G>C	c.(1492-1494)AAG>AAC	p.K498N	LAG3_uc001qqu.2_3'UTR	NM_002286	NP_002277	P18627	LAG3_HUMAN	lymphocyte-activation protein 3 precursor	498	Cytoplasmic (Potential).					integral to membrane	antigen binding|MHC class II protein binding				0						CTCAGAGCAAGATAGAGGAGC	0.313		NA											11	28					0	0	0	0
APOLD1	81575	broad.mit.edu	37	12	12940238	12940238	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:12940238G>A	uc001rau.3	+	2	576	c.492G>A	c.(490-492)GAG>GAA	p.E164E	DDX47_uc001rav.2_Intron|APOLD1_uc001raw.3_Silent_p.E133E	NM_001130415	NP_001123887	Q96LR9	APLD1_HUMAN	apolipoprotein L domain containing 1 isoform 1	164					angiogenesis|cell differentiation|lipid transport|lipoprotein metabolic process	extracellular region|integral to membrane|plasma membrane	lipid binding			ovary(1)	1		Prostate(47;0.0632)		BRCA - Breast invasive adenocarcinoma(232;0.0338)|GBM - Glioblastoma multiforme(207;0.149)		AGATGCGAGAGATCCTGAGCT	0.642		NA											40	99					0	0	0	0
GSG1	83445	broad.mit.edu	37	12	13243458	13243458	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:13243458C>T	uc001rbn.2	-	2	516	c.343G>A	c.(343-345)GAG>AAG	p.E115K	GSG1_uc001rbj.2_Missense_Mutation_p.E102K|GSG1_uc001rbk.2_Missense_Mutation_p.E102K|GSG1_uc001rbl.2_Missense_Mutation_p.E102K|GSG1_uc001rbm.2_Missense_Mutation_p.E102K|GSG1_uc001rbo.2_Missense_Mutation_p.E115K|GSG1_uc001rbp.2_Missense_Mutation_p.E115K|GSG1_uc001rbq.1_Missense_Mutation_p.E115K	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	102						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		ACAGTTTCCTCACAGGATAGC	0.542		NA											21	53					0	0	0	0
C12orf39	80763	broad.mit.edu	37	12	21680692	21680692	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:21680692G>C	uc001rfa.1	+	4	328	c.177G>C	c.(175-177)CGG>CGC	p.R59R	C12orf39_uc009ziv.1_RNA|C12orf39_uc009ziw.1_5'Flank	NM_030572	NP_085049	Q9BT56	SPXN_HUMAN	spexin precursor	59						extracellular region|nucleus|transport vesicle					0						ACCAGAGCCGGAGAAAGGACC	0.647		NA											4	10					0	0	0	0
PRPF40B	25766	broad.mit.edu	37	12	50029224	50029224	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:50029224G>A	uc001rur.1	+	13	1241	c.1177G>A	c.(1177-1179)GAT>AAT	p.D393N	PRPF40B_uc001rup.1_Missense_Mutation_p.D415N|PRPF40B_uc001ruq.1_Missense_Mutation_p.D387N|PRPF40B_uc001rus.1_Missense_Mutation_p.D336N	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	393					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GGTTTATGATGATGTCCTCTT	0.512		NA											46	154					0	0	0	0
BIN2	51411	broad.mit.edu	37	12	51685669	51685669	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:51685669G>C	uc001ryg.2	-	10	1273	c.1221C>G	c.(1219-1221)ATC>ATG	p.I407M	BIN2_uc009zlz.2_Missense_Mutation_p.I375M|BIN2_uc001ryh.2_Missense_Mutation_p.I283M|BIN2_uc010sng.1_Missense_Mutation_p.I381M	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	407						cytoplasm	protein binding			ovary(1)	1						AGGTCCTCTGGATAGAGGCTC	0.587		NA											29	93					0	0	0	0
KRT2	3849	broad.mit.edu	37	12	53045411	53045411	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:53045411C>G	uc001sat.2	-	1	549	c.516G>C	c.(514-516)CAG>CAC	p.Q172H		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	172	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		CCTTCACATTCTGGATCTCTG	0.527		NA											41	136					0	0	0	0
HNRNPA1	3178	broad.mit.edu	37	12	54675943	54675943	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:54675943G>A	uc001sfl.2	+	4	453	c.349G>A	c.(349-351)GAA>AAA	p.E117K	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.E117K|HNRNPA1_uc009zng.2_Missense_Mutation_p.E117K|HNRNPA1_uc009znh.2_Missense_Mutation_p.E117K|HNRNPA1_uc009zni.2_Missense_Mutation_p.E117K|HNRNPA1_uc001sfn.2_Missense_Mutation_p.E117K|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.E72K|HNRNPA1_uc009znj.1_Missense_Mutation_p.E72K	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	117	Globular B domain.|RRM 2.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						AGAAGACACTGAAGAACATCA	0.378		NA											16	38					0	0	0	0
COQ10A	93058	broad.mit.edu	37	12	56664084	56664084	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:56664084G>C	uc001sko.3	+	5	988	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	COQ10A_uc001skp.3_Missense_Mutation_p.E211Q|COQ10A_uc001skq.3_Missense_Mutation_p.E226Q	NM_144576	NP_653177	Q96MF6	CQ10A_HUMAN	coenzyme Q10 homolog A isoform a	243						mitochondrial inner membrane				ovary(1)	1						GATGTTCCATGAGGTGCACCA	0.498		NA											31	96					0	0	0	0
MBD6	114785	broad.mit.edu	37	12	57919593	57919593	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:57919593A>C	uc001soj.1	+	6	1066	c.842A>C	c.(841-843)CAC>CCC	p.H281P	MBD6_uc001sok.1_Missense_Mutation_p.H148P|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	281	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CTCCCCGCCCACCCTGGTCCT	0.662		NA											6	105					0	0	0	0
DCTN2	10540	broad.mit.edu	37	12	57924487	57924487	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:57924487C>T	uc001som.1	-	14	1323	c.1191G>A	c.(1189-1191)AAG>AAA	p.K397K	DCTN2_uc009zpu.1_Silent_p.K402K|DCTN2_uc009zpv.1_Silent_p.K310K|DCTN2_uc009zpw.1_Silent_p.K310K|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Silent_p.K310K|DCTN2_uc001sop.1_Silent_p.K310K|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Silent_p.K373K	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	397	Potential.				cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						TTCCCAGCTTCTTCATCCGTT	0.473		NA											11	143					0	0	0	0
XPOT	11260	broad.mit.edu	37	12	64813889	64813889	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:64813889G>A	uc001ssb.2	+	7	955	c.529G>A	c.(529-531)GAA>AAA	p.E177K	XPOT_uc009zqm.1_Missense_Mutation_p.E87K	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	177	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TACCATGAGGGAACAGTGCAT	0.363		NA											23	46					0	0	0	0
CAPS2	84698	broad.mit.edu	37	12	75692498	75692498	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:75692498C>T	uc001sxk.3	-	12	1267	c.1070G>A	c.(1069-1071)GGA>GAA	p.G357E	CAPS2_uc001sxm.3_Missense_Mutation_p.G125E|CAPS2_uc009zsa.2_Intron|CAPS2_uc001sxi.3_Missense_Mutation_p.G93E|CAPS2_uc001sxj.3_Missense_Mutation_p.G268E|CAPS2_uc001sxl.3_Missense_Mutation_p.G338E	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	357							calcium ion binding			ovary(2)	2						GTATTGTTTTCCTTTTCTTCG	0.353		NA											13	50					0	0	0	0
SYT1	6857	broad.mit.edu	37	12	79689973	79689973	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:79689973G>T	uc001sys.2	+	8	1270	c.599G>T	c.(598-600)CGA>CTA	p.R200L	SYT1_uc001syt.2_Missense_Mutation_p.R200L|SYT1_uc001syu.2_Missense_Mutation_p.R197L|SYT1_uc001syv.2_Missense_Mutation_p.R200L	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	200	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						AAAGTCCACCGAAAAACCCTT	0.383		NA											22	60					1.11e-09	1.17e-09	1	0
TMTC3	160418	broad.mit.edu	37	12	88547232	88547232	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:88547232G>C	uc001tau.2	+	3	574	c.354G>C	c.(352-354)AAG>AAC	p.K118N	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	118						integral to membrane	binding			skin(1)	1						TGGACAACAAGAGTAGTGTGA	0.328		NA											19	67					0	0	0	0
DEPDC4	120863	broad.mit.edu	37	12	100657384	100657384	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:100657384C>A	uc001thi.2	-	2	448	c.445G>T	c.(445-447)GAA>TAA	p.E149*	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Nonsense_Mutation_p.E82*|DEPDC4_uc009ztv.1_Nonsense_Mutation_p.E149*|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	149	DEP.				intracellular signal transduction						0						TCTTCAAATTCTAATTCCTTT	0.338		NA											27	51					2.45e-14	2.61e-14	1	0
DEPDC4	120863	broad.mit.edu	37	12	100657450	100657450	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:100657450G>C	uc001thi.2	-	2	382	c.379C>G	c.(379-381)CTA>GTA	p.L127V	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.L60V|DEPDC4_uc009ztv.1_Missense_Mutation_p.L127V|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	127	DEP.				intracellular signal transduction						0						TGATTCATTAGAACTTGGCAA	0.358		NA											31	71					0	0	0	0
PAH	5053	broad.mit.edu	37	12	103248921	103248921	+	Silent	SNP	G	G	A	rs62517208		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:103248921G>A	uc001tjq.1	-	7	1171	c.699C>T	c.(697-699)TTC>TTT	p.F233F	PAH_uc010swc.1_Silent_p.F233F	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	233			F -> L (in PKU; haplotypes 2,3).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TACTCTGCAGGAACTGAGAAA	0.488		NA											17	48					0	0	0	0
C12orf45	121053	broad.mit.edu	37	12	105388468	105388468	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:105388468G>C	uc001tlb.2	+	4	585	c.552G>C	c.(550-552)AAG>AAC	p.K184N		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	184											0						GTAAAAAAAAGAAATAGTCAA	0.368		NA											16	34					0	0	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105446691	105446691	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:105446691C>T	uc001tlc.2	-	11	1433	c.1306G>A	c.(1306-1308)GAA>AAA	p.E436K	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	436					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						ACCATGATTTCATTGACCTCC	0.363		NA									OREG0022073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	55					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109577263	109577263	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:109577263C>G	uc001tob.2	+	2	172	c.53C>G	c.(52-54)TCC>TGC	p.S18C	ACACB_uc001toc.2_Missense_Mutation_p.S18C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	18					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CTGACCTTTTCCTGGTTAAAA	0.433		NA											10	91					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109629726	109629726	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:109629726C>T	uc001tob.2	+	15	2489	c.2370C>T	c.(2368-2370)TGC>TGT	p.C790C	ACACB_uc001toc.2_Silent_p.C790C	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	790					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TCAGAACGTGCATGACAGATT	0.517		NA											6	76					0	0	0	0
TRAFD1	10906	broad.mit.edu	37	12	112590581	112590581	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:112590581G>A	uc001ttp.2	+	12	1821	c.1735G>A	c.(1735-1737)GAA>AAA	p.E579K	TRAFD1_uc001tto.2_Missense_Mutation_p.E579K	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	579	Poly-Glu.				negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						TGCAGAAGAGGAAGAGGAGGA	0.493		NA											14	72					0	0	0	0
C12orf51	283450	broad.mit.edu	37	12	112699141	112699141	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:112699141G>A	uc009zwc.2	-	11	1563	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L	C12orf51_uc010syk.1_Silent_p.L338L|C12orf51_uc001tts.2_Silent_p.L338L|C12orf51_uc001ttt.3_Silent_p.L336L	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CACTATTTATGAGGGCAGTTG	0.458		NA											19	55					0	0	0	0
C12orf49	79794	broad.mit.edu	37	12	117175661	117175661	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:117175661C>G	uc001tvz.1	-	1	183	c.45G>C	c.(43-45)AAG>AAC	p.K15N	RNFT2_uc009zwn.2_5'Flank|RNFT2_uc001twb.3_5'Flank|RNFT2_uc001twa.3_5'Flank|C12orf49_uc009zwm.1_Missense_Mutation_p.E38Q	NM_024738	NP_079014	Q9H741	CL049_HUMAN	hypothetical protein LOC79794 precursor	15						extracellular region				ovary(1)	1	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0281)		GCACCCACCTCTTCCGCAGAA	0.592		NA											12	24					0	0	0	0
C12orf43	64897	broad.mit.edu	37	12	121448689	121448689	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:121448689G>A	uc001tzh.1	-	3	252	c.229C>T	c.(229-231)CAG>TAG	p.Q77*	C12orf43_uc009zxa.1_Nonsense_Mutation_p.Q108*|C12orf43_uc010szo.1_Nonsense_Mutation_p.Q35*|C12orf43_uc010szp.1_Nonsense_Mutation_p.Q77*|C12orf43_uc001tzi.1_Nonsense_Mutation_p.Q77*	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	77											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGGGTGGTCTGAAGCTCGTTG	0.418		NA											50	95					0	0	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122962395	122962395	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:122962395G>A	uc001ucn.2	-	13	1469	c.1338C>T	c.(1336-1338)CTC>CTT	p.L446L	ZCCHC8_uc001ucl.2_Silent_p.L57L|ZCCHC8_uc001ucm.2_Silent_p.L208L|ZCCHC8_uc009zxp.2_Silent_p.L208L|ZCCHC8_uc009zxq.2_Silent_p.L208L	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	446						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TACCTGAATCGAGCTCCATGT	0.333		NA											14	43					0	0	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122967208	122967208	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:122967208C>G	uc001ucn.2	-	8	837	c.706G>C	c.(706-708)GAA>CAA	p.E236Q	ZCCHC8_uc001ucm.2_5'UTR|ZCCHC8_uc009zxp.2_5'UTR|ZCCHC8_uc009zxq.2_5'UTR	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	236	CCHC-type.					catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		ATTTGGTGTTCTTCAGAACCA	0.289		NA											14	44					0	0	0	0
KNTC1	9735	broad.mit.edu	37	12	123014683	123014683	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:123014683G>C	uc001ucv.2	+	2	236	c.73G>C	c.(73-75)GAA>CAA	p.E25Q	KNTC1_uc010taf.1_Missense_Mutation_p.E25Q	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	25					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTCAAGAAAAGAACATGGAAC	0.383		NA											34	113					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123782660	123782660	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:123782660G>A	uc010tap.1	-	30	3904	c.3904C>T	c.(3904-3906)CGT>TGT	p.R1302C	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.R1301C|SBNO1_uc010taq.1_Missense_Mutation_p.R253C	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1302							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TAATATGTACGGCAACGAAGA	0.413		NA											35	78					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123810857	123810857	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr12:123810857G>A	uc010tap.1	-	13	1717	c.1717C>T	c.(1717-1719)CAG>TAG	p.Q573*	SBNO1_uc010tao.1_Nonsense_Mutation_p.Q572*|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Nonsense_Mutation_p.Q573*|SBNO1_uc001ueu.2_Nonsense_Mutation_p.Q572*|SBNO1_uc001uev.2_Nonsense_Mutation_p.Q571*|SBNO1_uc009zxy.1_Nonsense_Mutation_p.Q538*	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	573							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GCAGCTTGCTGAAACCGCTCT	0.403		NA											20	175					0	0	0	0
GJB6	10804	broad.mit.edu	37	13	20797248	20797248	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:20797248C>T	uc001umz.3	-	3	925	c.372G>A	c.(370-372)CAG>CAA	p.Q124Q	GJB6_uc001unc.3_Silent_p.Q124Q|GJB6_uc001una.3_Silent_p.Q124Q|GJB6_uc001und.3_Silent_p.Q124Q|GJB6_uc001unb.3_Silent_p.Q124Q	NM_006783	NP_006774	O95452	CXB6_HUMAN	gap junction protein, beta 6	124	Cytoplasmic (Potential).			Q -> H (in Ref. 1; CAA06611).	cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				ovary(1)	1		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		TCCGAACCTTCTGCTTTTTAA	0.463		NA											15	48					0	0	0	0
FLT1	2321	broad.mit.edu	37	13	29001376	29001376	+	Silent	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:29001376C>A	uc001usb.3	-	10	1641	c.1356G>T	c.(1354-1356)CTG>CTT	p.L452L	FLT1_uc010aar.1_Silent_p.L452L|FLT1_uc001usc.3_Silent_p.L452L|FLT1_uc010tdp.1_Silent_p.L452L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	452	Ig-like C2-type 5.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CGGTACAAGTCAGGATTTGTC	0.488		NA											18	61					9.17e-09	9.64e-09	1	0
KATNAL1	84056	broad.mit.edu	37	13	30804674	30804674	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:30804674G>A	uc001uss.2	-	8	1044	c.943C>T	c.(943-945)CGA>TGA	p.R315*	KATNAL1_uc001ust.2_Nonsense_Mutation_p.R315*	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	315						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		GTTCCTCTTCGACTGCAGATA	0.348		NA											6	40					0	0	0	0
POSTN	10631	broad.mit.edu	37	13	38154776	38154776	+	Missense_Mutation	SNP	G	G	A	rs145787730	byFrequency	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:38154776G>A	uc001uwo.3	-	11	1569	c.1451C>T	c.(1450-1452)GCG>GTG	p.A484V	POSTN_uc010tet.1_Missense_Mutation_p.A12V|POSTN_uc001uwp.3_Missense_Mutation_p.A484V|POSTN_uc001uwr.2_Missense_Mutation_p.A484V|POSTN_uc001uwq.2_Missense_Mutation_p.A484V|POSTN_uc010teu.1_Missense_Mutation_p.A484V|POSTN_uc010tev.1_Missense_Mutation_p.A484V|POSTN_uc010tew.1_Missense_Mutation_p.A484V|POSTN_uc010tex.1_Missense_Mutation_p.A399V	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	484	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TATGTGAATCGCACCGTTTCT	0.443		NA											22	145					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39450265	39450265	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:39450265G>C	uc001uwv.2	+	19	8697	c.8388G>C	c.(8386-8388)TGG>TGC	p.W2796C		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2796	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TACAGCAGTGGAGCTTTGTCT	0.418		NA											27	150					0	0	0	0
NAA16	79612	broad.mit.edu	37	13	41894879	41894879	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:41894879C>G	uc001uyf.2	+	4	645	c.321C>G	c.(319-321)CTC>CTG	p.L107L	NAA16_uc010tfg.1_RNA|NAA16_uc001uye.3_Silent_p.L107L|NAA16_uc001uyd.3_Silent_p.L107L	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	107	TPR 2.				N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						GAAATGCCCTCAAATTAGATA	0.358		NA											3	71					0	0	0	0
CPB2	1361	broad.mit.edu	37	13	46629983	46629983	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:46629983G>C	uc001vaw.2	-	10	1068	c.1001C>G	c.(1000-1002)TCT>TGT	p.S334C	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Missense_Mutation_p.S297C	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	334					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		GGCTACTAGAGACTGGAAGCA	0.333		NA											16	72					0	0	0	0
RBM26	64062	broad.mit.edu	37	13	79911392	79911392	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:79911392G>A	uc001vkz.2	-	19	2598	c.2584C>T	c.(2584-2586)CAT>TAT	p.H862Y	RBM26_uc001vky.2_Missense_Mutation_p.H833Y|RBM26_uc001vla.2_Missense_Mutation_p.H836Y|RBM26_uc010tia.1_Missense_Mutation_p.H217Y|RBM26_uc001vkx.2_Missense_Mutation_p.H572Y	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	860					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CCTCTTGAATGAATTCCTCTG	0.547		NA											4	100					0	0	0	0
ABCC4	10257	broad.mit.edu	37	13	95858999	95858999	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:95858999G>A	uc001vmd.3	-	8	1067	c.948C>T	c.(946-948)CTC>CTT	p.L316L	ABCC4_uc010afk.2_Silent_p.L316L|ABCC4_uc001vme.2_Silent_p.L316L|ABCC4_uc010tih.1_Silent_p.L241L|ABCC4_uc001vmf.2_Silent_p.L273L|ABCC4_uc010afl.1_Silent_p.L273L|ABCC4_uc010afm.1_Silent_p.L329L	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	316	ABC transmembrane type-1 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TCATCCCTCTGAGGCAGGAAC	0.413		NA											21	220					0	0	0	0
RAP2A	5911	broad.mit.edu	37	13	98086811	98086811	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:98086811C>T	uc001vnd.2	+	1	337	c.87C>T	c.(85-87)ATC>ATT	p.I29I		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	29					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			GCACCTTCATCGAGAAATACG	0.607		NA											18	90					0	0	0	0
TM9SF2	9375	broad.mit.edu	37	13	100204467	100204467	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:100204467G>A	uc001voj.1	+	13	1508	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	TM9SF2_uc010afz.1_Missense_Mutation_p.E294K	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	459	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					CCTCTGGGGAGAAGGATCTTC	0.423		NA											22	132					0	0	0	0
PCCA	5095	broad.mit.edu	37	13	100764110	100764110	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr13:100764110C>G	uc001voo.2	+	3	237	c.199C>G	c.(199-201)CTT>GTT	p.L67V	PCCA_uc010aga.2_Missense_Mutation_p.L41V|PCCA_uc010tiz.1_Missense_Mutation_p.L67V	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	67	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TGATAAAATTCTTGTTGCTAA	0.303		NA											9	24					0	0	0	0
RBM23	55147	broad.mit.edu	37	14	23371581	23371581	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:23371581G>T	uc001whg.2	-	11	1140	c.941C>A	c.(940-942)TCT>TAT	p.S314Y	RBM23_uc001whh.2_Missense_Mutation_p.S298Y|RBM23_uc001whi.2_Missense_Mutation_p.S280Y|RBM23_uc010tne.1_Missense_Mutation_p.S144Y|RBM23_uc001whj.2_Missense_Mutation_p.S64Y	NM_001077351	NP_001070819	Q86U06	RBM23_HUMAN	RNA binding motif protein 23 isoform 1	314	RRM 2.				mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		GGCACACTCAGAATCAGAGAA	0.532		NA											15	35					3.46e-05	3.57e-05	1	0
MYH7	4625	broad.mit.edu	37	14	23884362	23884362	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:23884362C>A	uc001wjx.2	-	37	5507	c.5401G>T	c.(5401-5403)GAG>TAG	p.E1801*		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1801	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCGATCTGCTCGGCTTCGTCC	0.622		NA											15	103					1.36e-06	1.42e-06	1	0
PSME1	5720	broad.mit.edu	37	14	24606752	24606752	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:24606752G>C	uc001wmg.2	+	5	364	c.270G>C	c.(268-270)AAG>AAC	p.K90N	PSME1_uc001wmh.2_Missense_Mutation_p.K90N	NM_006263	NP_006254	Q06323	PSME1_HUMAN	proteasome activator subunit 1 isoform 1	90					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00831)		ATGAAAAGAAGAAGGGGGAGG	0.483		NA											12	64					0	0	0	0
RNF31	55072	broad.mit.edu	37	14	24618025	24618025	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:24618025G>C	uc001wmn.1	+	5	820	c.571G>C	c.(571-573)GAA>CAA	p.E191Q	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Missense_Mutation_p.E40Q|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.E6Q|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	191	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GCAGCTTTCAGAATTTGACCC	0.483		NA											47	240					0	0	0	0
LTB4R	1241	broad.mit.edu	37	14	24785338	24785338	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:24785338T>C	uc001wos.2	+	2	802	c.481T>C	c.(481-483)TGG>CGG	p.W161R	LTB4R_uc010alp.2_Missense_Mutation_p.W161R|LTB4R_uc001wou.2_Missense_Mutation_p.W161R	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	161	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		AGTAGTGCCCTGGAAAACGAA	0.637		NA											3	119					0	0	0	0
KIAA0391	9692	broad.mit.edu	37	14	35593114	35593114	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:35593114C>T	uc001wsy.1	+	2	1023	c.663C>T	c.(661-663)ATC>ATT	p.I221I	KIAA0391_uc010tps.1_Silent_p.I126I|KIAA0391_uc001wsz.1_Silent_p.I221I|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Silent_p.I221I|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	221					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		GGGGATTGATCCATTCAGACA	0.373		NA											17	35					0	0	0	0
FSCB	84075	broad.mit.edu	37	14	44974621	44974621	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:44974621C>T	uc001wvn.2	-	1	1879	c.1570G>A	c.(1570-1572)GAA>AAA	p.E524K		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	524	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGCTGAATTTCAGCAGAGGCC	0.507		NA											5	35					0	0	0	0
KLHL28	54813	broad.mit.edu	37	14	45414609	45414609	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:45414609C>G	uc001wvq.2	-	2	769	c.523G>C	c.(523-525)GAG>CAG	p.E175Q	KLHL28_uc001wvr.2_Missense_Mutation_p.E175Q|KLHL28_uc001wvt.3_Missense_Mutation_p.E175Q	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	175										ovary(1)	1						TGTGTAAGCTCAAAAAACTCT	0.383		NA											4	103					0	0	0	0
C14orf101	54916	broad.mit.edu	37	14	57082694	57082694	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:57082694C>A	uc001xcm.2	+	8	1012	c.890C>A	c.(889-891)TCA>TAA	p.S297*	C14orf101_uc001xcj.2_RNA|C14orf101_uc010aot.1_Nonsense_Mutation_p.S297*|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_5'UTR|C14orf101_uc001xco.2_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	297						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		ACCGAACTCTCATTCAACATC	0.313		NA											38	123					6.69e-21	7.19e-21	1	0
EXOC5	10640	broad.mit.edu	37	14	57699411	57699411	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:57699411G>C	uc001xct.2	-	10	1163	c.912C>G	c.(910-912)CTC>CTG	p.L304L	EXOC5_uc001xcs.2_5'Flank|EXOC5_uc010trg.1_Silent_p.L249L|EXOC5_uc010trh.1_Silent_p.L239L	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	304					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						AGAGATTTTTGAGATATTGCT	0.254		NA											3	55					0	0	0	0
SPTB	6710	broad.mit.edu	37	14	65259779	65259779	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:65259779C>G	uc001xht.2	-	13	2656	c.2602G>C	c.(2602-2604)GAG>CAG	p.E868Q	SPTB_uc001xhr.2_Missense_Mutation_p.E868Q|SPTB_uc001xhs.2_Missense_Mutation_p.E868Q|SPTB_uc001xhu.2_Missense_Mutation_p.E868Q	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	868	Spectrin 6.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGCCACTTCTCCTTCTCTCCC	0.602		NA											19	44					0	0	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935785	94935785	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr14:94935785C>G	uc001ydf.2	-	2	608	c.447G>C	c.(445-447)AAG>AAC	p.K149N	SERPINA9_uc001yde.2_Intron|SERPINA9_uc010avc.2_5'UTR|SERPINA9_uc001ydg.2_Missense_Mutation_p.K113N|SERPINA9_uc001ydh.1_Missense_Mutation_p.K149N|SERPINA9_uc001ydi.1_Missense_Mutation_p.K113N	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	131					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CACTTCCCATCTTCAAGGTCA	0.512		NA											30	153					0	0	0	0
MKRN3	7681	broad.mit.edu	37	15	23811327	23811327	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:23811327C>T	uc001ywh.3	+	1	874	c.398C>T	c.(397-399)TCG>TTG	p.S133L	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.S133L	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	133						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGTGGCGTTTCGCCGCCTGGG	0.627		NA											15	61					0	0	0	0
MTMR15	22909	broad.mit.edu	37	15	31220836	31220836	+	Missense_Mutation	SNP	G	G	A	rs139319999		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:31220836G>A	uc001zff.2	+	11	2860	c.2569G>A	c.(2569-2571)GAT>AAT	p.D857N	MTMR15_uc001zfe.2_Missense_Mutation_p.D462N	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	857					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		TGGGATTCCGGATGTCTTCAG	0.557		NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					22	135					0	0	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40257961	40257961	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:40257961G>C	uc001zkm.1	+	8	984	c.934G>C	c.(934-936)GAG>CAG	p.E312Q	EIF2AK4_uc001zkl.2_Missense_Mutation_p.E312Q|EIF2AK4_uc010bbj.1_Missense_Mutation_p.E41Q	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	312	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CTTGTTGTATGAGTGGGTCCT	0.408		NA											16	63					0	0	0	0
GANC	2595	broad.mit.edu	37	15	42632913	42632913	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:42632913G>A	uc001zpi.2	+	18	2427	c.2113G>A	c.(2113-2115)GAA>AAA	p.E705K		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	705					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GTTCCCTGATGAACTAAAGAC	0.239		NA											23	71					0	0	0	0
LCMT2	9836	broad.mit.edu	37	15	43620956	43620956	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:43620956C>T	uc001zrg.2	-	1	1936	c.1732G>A	c.(1732-1734)GAC>AAC	p.D578N	LCMT2_uc010udn.1_Missense_Mutation_p.D157N|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	578					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	GGCTGGATGTCTACTGACTCC	0.517		NA											35	81					0	0	0	0
LCMT2	9836	broad.mit.edu	37	15	43621022	43621022	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:43621022C>G	uc001zrg.2	-	1	1870	c.1666G>C	c.(1666-1668)GAG>CAG	p.E556Q	LCMT2_uc010udn.1_Missense_Mutation_p.E135Q|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	556					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	AATGGCTCCTCAGAAGCCCCG	0.557		NA											9	121					0	0	0	0
ZSCAN29	146050	broad.mit.edu	37	15	43653641	43653641	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:43653641C>T	uc001zrk.1	-	5	2336	c.2189G>A	c.(2188-2190)GGA>GAA	p.G730E	ZSCAN29_uc001zrj.1_Missense_Mutation_p.G610E|ZSCAN29_uc010bdf.1_3'UTR|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Missense_Mutation_p.G340E	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	730					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		AGGTTTCTCTCCTGTGTGGAT	0.433		NA											15	59					0	0	0	0
DUOXA1	90527	broad.mit.edu	37	15	45415129	45415129	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:45415129G>A	uc001zuq.1	-	1	113	c.84C>T	c.(82-84)ATC>ATT	p.I28I	DUOXA1_uc010uem.1_Silent_p.I28I|DUOXA1_uc001zup.2_Silent_p.I28I|DUOXA1_uc010bec.2_Silent_p.I28I|DUOXA1_uc001zur.1_Silent_p.I28I|DUOXA1_uc010bed.1_Silent_p.I28I	NM_144565	NP_653166	Q1HG43	DOXA1_HUMAN	Numb-interacting protein	28	Helical; (Potential).				protein transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		GAAAGATCATGATGATGCTGG	0.562		NA											30	62					0	0	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45695714	45695714	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:45695714G>C	uc001zve.2	+	1	1196	c.1087G>C	c.(1087-1089)GAG>CAG	p.E363Q	uc001zvd.2_5'Flank|SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	363						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		ATTTGACCGAGAGGTGAATGG	0.662		NA											6	53					0	0	0	0
USP50	373509	broad.mit.edu	37	15	50830917	50830917	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:50830917G>A	uc001zyq.3	-	5	987	c.807C>T	c.(805-807)TTC>TTT	p.F269F		NM_203494	NP_987090	E9PP86	E9PP86_HUMAN	ubiquitin specific protease 50	264					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			lung(1)|breast(1)	2				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		TTTTTAGGTGGAAAATAATTA	0.274		NA											6	5					0	0	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499805	59499805	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:59499805G>C	uc002agb.2	+	1	764	c.666G>C	c.(664-666)TTG>TTC	p.L222F	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	222					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	TTCGTTTCTTGATTGGACAAA	0.438		NA											16	72					0	0	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59499959	59499959	+	Missense_Mutation	SNP	G	G	C	rs139039522		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:59499959G>C	uc002agb.2	+	1	918	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	274					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	TAAAGATCCTGAGCAATGGAA	0.433		NA											9	61					0	0	0	0
PDCD7	10081	broad.mit.edu	37	15	65412134	65412134	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:65412134C>G	uc002aol.2	-	3	1223	c.1168G>C	c.(1168-1170)GAA>CAA	p.E390Q		NM_005707	NP_005698	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	390	Potential.				apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex					0						tgtttcttttctaattctctt	0.274		NA											12	55					0	0	0	0
MAP2K1	5604	broad.mit.edu	37	15	66781559	66781559	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:66781559C>G	uc010bhq.2	+	9	1442	c.967C>G	c.(967-969)CCA>GCA	p.P323A	MAP2K1_uc010ujp.1_Missense_Mutation_p.P301A	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	323	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GCAGCCTCCTCCAAAACTGCC	0.483		NA							Cardiofaciocutaneous_syndrome				18	60					0	0	0	0
KIF23	9493	broad.mit.edu	37	15	69733362	69733362	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:69733362G>C	uc002asb.2	+	18	2440	c.2323G>C	c.(2323-2325)GAG>CAG	p.E775Q	KIF23_uc002asc.2_Intron|KIF23_uc010bii.2_Missense_Mutation_p.E665Q|KIF23_uc010ukc.1_Intron	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	775					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						TGAAGGCAGGGAGGTGGTTCC	0.448		NA											5	42					0	0	0	0
PKM2	5315	broad.mit.edu	37	15	72499611	72499611	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:72499611C>T	uc002atx.1	-	7	1085	c.844G>A	c.(844-846)GAA>AAA	p.E282K	PKM2_uc002ats.1_5'Flank|PKM2_uc002att.1_Missense_Mutation_p.E48K|PKM2_uc002atu.1_Missense_Mutation_p.E48K|PKM2_uc010bit.1_Missense_Mutation_p.E287K|PKM2_uc010uki.1_Missense_Mutation_p.E356K|PKM2_uc002atv.1_Missense_Mutation_p.E317K|PKM2_uc002atw.1_Missense_Mutation_p.E282K|PKM2_uc002aty.1_Missense_Mutation_p.E282K|PKM2_uc010ukj.1_Missense_Mutation_p.E267K|PKM2_uc010ukk.1_Missense_Mutation_p.E208K|PKM2_uc010biu.1_Missense_Mutation_p.E303K|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	282					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	TCCAGGATTTCATCAAACCTG	0.478		NA											15	46					0	0	0	0
CELF6	60677	broad.mit.edu	37	15	72608214	72608214	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:72608214G>A	uc002auh.2	-	2	627	c.317C>T	c.(316-318)GCA>GTA	p.A106V	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010ukm.1_Missense_Mutation_p.A106V|CELF6_uc002aui.2_Silent_p.C228C|CELF6_uc002auj.2_5'UTR	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	106	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						CTCGTGCAGTGCACTCTGGGC	0.627		NA											7	13					0	0	0	0
TMEM202	338949	broad.mit.edu	37	15	72691140	72691140	+	Silent	SNP	A	A	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:72691140A>G	uc002auq.2	+	2	228	c.228A>G	c.(226-228)CCA>CCG	p.P76P	TMEM202_uc002aur.2_Intron	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	76						integral to membrane				central_nervous_system(1)|skin(1)	2						CCATGTCCCCACTGAACTGGG	0.527		NA											26	56					0	0	0	0
STRA6	64220	broad.mit.edu	37	15	74477352	74477352	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:74477352G>C	uc002axk.2	-	13	1317	c.1135C>G	c.(1135-1137)CTG>GTG	p.L379V	STRA6_uc002axi.2_Missense_Mutation_p.L188V|STRA6_uc010ulh.1_Missense_Mutation_p.L417V|STRA6_uc002axj.2_Missense_Mutation_p.L418V|STRA6_uc010bji.2_Missense_Mutation_p.L379V|STRA6_uc002axl.2_Missense_Mutation_p.L311V|STRA6_uc002axm.2_Missense_Mutation_p.L379V|STRA6_uc002axn.2_Missense_Mutation_p.L370V|STRA6_uc010uli.1_Missense_Mutation_p.L416V|STRA6_uc010bjj.1_RNA	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	379	Helical; (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						ATCAGGACCAGGAAGGTGAGT	0.597		NA											10	36					0	0	0	0
CYP1A2	1544	broad.mit.edu	37	15	75044189	75044189	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:75044189G>C	uc002ayr.1	+	4	1100	c.1036G>C	c.(1036-1038)GAG>CAG	p.E346Q		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	346					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	GATCCAGAAGGAGCTGGGTAC	0.433		NA											16	70					0	0	0	0
CYP1A2	1544	broad.mit.edu	37	15	75047131	75047131	+	Splice_Site	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:75047131G>C	uc002ayr.1	+	7	1318	c.1254_splice	c.e7-1	p.P418_splice		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,						alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TCCTCTTGCAGAGAGCTGTGG	0.592		NA											18	112					0	0	0	0
LINGO1	84894	broad.mit.edu	37	15	77907918	77907918	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:77907918C>A	uc002bct.1	-	2	383	c.331G>T	c.(331-333)GAG>TAG	p.E111*	LINGO1_uc002bcu.1_Nonsense_Mutation_p.E105*	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	111	Extracellular (Potential).|LRR 2.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						GCGCCGGGCTCCACGGCGCTC	0.617		NA											6	10					5.94e-07	6.19e-07	1	0
FAM154B	283726	broad.mit.edu	37	15	82575272	82575272	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:82575272G>C	uc002bgv.2	+	3	1135	c.1066G>C	c.(1066-1068)GAG>CAG	p.E356Q	FAM154B_uc010unr.1_Missense_Mutation_p.E341Q|FAM154B_uc010uns.1_RNA	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	hypothetical protein LOC283726	356										skin(2)	2						GTACTCTGTAGAGTACACACC	0.398		NA											11	59					0	0	0	0
BNC1	646	broad.mit.edu	37	15	83932315	83932315	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:83932315G>A	uc002bjt.1	-	4	1776	c.1688C>T	c.(1687-1689)TCA>TTA	p.S563L	BNC1_uc010uos.1_Missense_Mutation_p.S551L	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	563					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GTCTTCATCTGAGCTGAGGTT	0.478		NA											25	174					0	0	0	0
ISG20	3669	broad.mit.edu	37	15	89195491	89195491	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:89195491C>T	uc002bmv.1	+	3	672	c.379C>T	c.(379-381)CGT>TGT	p.R127C	ISG20_uc002bmu.1_RNA|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	127					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			CCACTGCAGGCGTGTCTCCCT	0.463		NA											9	76					0	0	0	0
WDR90	197335	broad.mit.edu	37	16	706411	706411	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:706411C>G	uc002cii.1	+	18	2130	c.2076C>G	c.(2074-2076)TAC>TAG	p.Y692*	WDR90_uc002cig.1_3'UTR|WDR90_uc002cih.1_3'UTR|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Nonsense_Mutation_p.Y219*|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	692	WD 5.									ovary(1)	1		Hepatocellular(780;0.0218)				CCCGGGTGTACCACATGCTGG	0.697		NA											5	19					0	0	0	0
RPUSD1	113000	broad.mit.edu	37	16	836894	836894	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:836894G>A	uc002cka.2	-	4	678	c.444C>T	c.(442-444)CTC>CTT	p.L148L	RPUSD1_uc002ckb.2_Silent_p.L148L|RPUSD1_uc002ckc.2_Silent_p.L19L|RPUSD1_uc002ckd.2_Missense_Mutation_p.S114L|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing	148					pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				CCAGAACCACGAGATCTGTGA	0.632		NA											31	95					0	0	0	0
TBC1D24	57465	broad.mit.edu	37	16	2547031	2547031	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:2547031C>T	uc002cql.2	+	2	1022	c.882C>T	c.(880-882)CTC>CTT	p.L294L	TBC1D24_uc002cqk.2_Silent_p.L294L|TBC1D24_uc002cqm.2_Silent_p.L294L|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	294					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CCATCCGCCTCTTCTCCCGCA	0.597		NA											21	51					0	0	0	0
ACSM2A	123876	broad.mit.edu	37	16	20487070	20487070	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:20487070G>A	uc010bwe.2	+	9	1312	c.1073G>A	c.(1072-1074)CGA>CAA	p.R358Q	ACSM2A_uc010vax.1_Missense_Mutation_p.R279Q|ACSM2A_uc002dhf.3_Missense_Mutation_p.R358Q|ACSM2A_uc002dhg.3_Missense_Mutation_p.R358Q|ACSM2A_uc010vay.1_Missense_Mutation_p.R279Q|ACSM2A_uc002dhh.3_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	358					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CTGGACATCCGAGAATCCTAT	0.493		NA											27	245					0	0	0	0
USP31	57478	broad.mit.edu	37	16	23113736	23113736	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:23113736C>G	uc002dll.2	-	6	1138	c.1138G>C	c.(1138-1140)GAT>CAT	p.D380H		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	380					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		TCGTCTGTATCACAAAAGGAA	0.383		NA											29	70					0	0	0	0
KCTD13	253980	broad.mit.edu	37	16	29934634	29934634	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:29934634G>C	uc002duv.2	-	2	482	c.291C>G	c.(289-291)CTC>CTG	p.L97L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	97	BTB.				cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						GCAGGTAATTGAGGATTGTAC	0.612		NA											8	45					0	0	0	0
ZNF764	92595	broad.mit.edu	37	16	30569449	30569449	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:30569449C>G	uc002dyq.2	-	1	136	c.55G>C	c.(55-57)GAG>CAG	p.E19Q	ZNF764_uc002dyr.1_Missense_Mutation_p.E19Q	NM_033410	NP_219363	Q96H86	ZN764_HUMAN	zinc finger protein 764	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCCCTCCACTCGGGTCCGGCC	0.726		NA											11	11					0	0	0	0
ZNF629	23361	broad.mit.edu	37	16	30793399	30793399	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:30793399C>A	uc002dzs.1	-	3	2458	c.2250G>T	c.(2248-2250)AAG>AAT	p.K750N		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CGGAAGAGCTCTTCCCCAGCT	0.617		NA											36	100					6.06e-23	6.52e-23	1	0
STX4	6810	broad.mit.edu	37	16	31049870	31049870	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:31049870G>A	uc002eal.2	+	8	828	c.604G>A	c.(604-606)GAG>AAG	p.E202K	STX4_uc002eak.2_Missense_Mutation_p.E200K|STX4_uc002eam.2_Missense_Mutation_p.E124K	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	202	Cytoplasmic (Potential).|Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						GGCCTTAAATGAGATCTCGGC	0.552		NA											20	55					0	0	0	0
PYCARD	29108	broad.mit.edu	37	16	31213912	31213912	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:31213912C>G	uc010cak.2	-	1	340	c.100G>C	c.(100-102)GAG>CAG	p.E34Q	PYCARD_uc002ebm.2_Missense_Mutation_p.E34Q	NM_013258	NP_037390	Q9ULZ3	ASC_HUMAN	PYD and CARD domain containing isoform a	34	DAPIN.				induction of apoptosis|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex	caspase activator activity|cysteine-type endopeptidase activity|protein homodimerization activity|Pyrin domain binding				0						CCGTAGCCCTCGCGCAGCGGC	0.677		NA											20	31					0	0	0	0
NKD1	85407	broad.mit.edu	37	16	50666202	50666202	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:50666202G>A	uc002egg.1	+	9	930	c.706G>A	c.(706-708)GAC>AAC	p.D236N		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	236					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GTTCCAGGGTGACAGCCGCCT	0.557		NA											16	38					0	0	0	0
CCDC135	84229	broad.mit.edu	37	16	57761225	57761225	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:57761225G>A	uc002emi.2	+	15	2189	c.2100G>A	c.(2098-2100)CTG>CTA	p.L700L	CCDC135_uc002emj.2_Silent_p.L700L|CCDC135_uc002emk.2_Silent_p.L635L	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	700	Potential.					cytoplasm				central_nervous_system(1)	1						TGGAGATTCTGAAGCTTCGAG	0.433		NA											44	111					0	0	0	0
CES2	8824	broad.mit.edu	37	16	66975679	66975679	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:66975679G>A	uc002eqr.2	+	8	2257	c.1257G>A	c.(1255-1257)AGG>AGA	p.R419R	CES2_uc002eqq.2_Silent_p.R419R|CES2_uc002eqs.2_Silent_p.R262R	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	355					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		AGGTCATGAGGATCTATGATA	0.572		NA											62	177					0	0	0	0
HSD11B2	3291	broad.mit.edu	37	16	67469873	67469873	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:67469873C>T	uc002etd.2	+	3	608	c.492C>T	c.(490-492)CTC>CTT	p.L164L		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	164					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)	TGTGGGGCCTCGTCAACAACG	0.602		NA											22	78					0	0	0	0
NFATC3	4775	broad.mit.edu	37	16	68160439	68160439	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:68160439C>T	uc002evo.1	+	3	1537	c.1327C>T	c.(1327-1329)CAT>TAT	p.H443Y	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.H443Y|NFATC3_uc002evm.1_Missense_Mutation_p.H443Y|NFATC3_uc002evn.1_Missense_Mutation_p.H443Y|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	443	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TAAAACTCATCATCGAGCCCA	0.433		NA											33	71					0	0	0	0
ZFP1	162239	broad.mit.edu	37	16	75203755	75203755	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:75203755C>T	uc002fdo.2	+	4	911	c.747C>T	c.(745-747)TTC>TTT	p.F249F	ZFP1_uc002fdp.2_Silent_p.F194F|ZFP1_uc010cgt.2_Silent_p.F216F|ZFP1_uc010cgs.2_Silent_p.F194F|ZFP1_uc002fdq.2_Silent_p.F249F	NM_153688	NP_710155	Q6P2D0	ZFP1_HUMAN	zinc finger protein 1 homolog	249	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GAAAAGCTTTCACCCACCAGT	0.443		NA											28	59					0	0	0	0
PKD1L2	114780	broad.mit.edu	37	16	81145966	81145966	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:81145966G>A	uc002fgh.1	-	42	6786	c.6786C>T	c.(6784-6786)TTC>TTT	p.F2262F	PKD1L2_uc002fgf.1_Silent_p.F62F|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2262	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTGTCTCACTGAAGCTGATGC	0.532		NA											19	38					0	0	0	0
TRAPPC2L	51693	broad.mit.edu	37	16	88925146	88925146	+	Silent	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr16:88925146C>A	uc002fmc.2	+	2	206	c.153C>A	c.(151-153)GTC>GTA	p.V51V	GALNS_uc002fly.3_5'Flank|GALNS_uc010cid.2_5'Flank|GALNS_uc002flz.3_5'Flank|GALNS_uc002fma.2_5'Flank|TRAPPC2L_uc010cie.2_RNA|TRAPPC2L_uc002fmd.3_Silent_p.V51V|TRAPPC2L_uc002fme.3_Silent_p.V51V|TRAPPC2L_uc002fmf.2_5'Flank|uc002fmg.2_5'Flank	NM_016209	NP_057293	Q9UL33	TPC2L_HUMAN	trafficking protein particle complex 2-like	51					ER to Golgi vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm					0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		AGGCCCTGGTCGACCAGAGGG	0.577		NA											15	51					0.00316338	0.00323468	1	0
ABR	29	broad.mit.edu	37	17	960284	960284	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:960284G>C	uc002fsd.2	-	13	1550	c.1440C>G	c.(1438-1440)TTC>TTG	p.F480L	ABR_uc002fse.2_Missense_Mutation_p.F434L|ABR_uc010vqg.1_Missense_Mutation_p.F262L|ABR_uc002fsg.2_Missense_Mutation_p.F443L|ABR_uc002fsh.1_Intron	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	480	C2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TCCTAAGCTTGAAACAGGATC	0.582		NA											82	118					0	0	0	0
TMEM95	339168	broad.mit.edu	37	17	7259355	7259355	+	Silent	SNP	T	T	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:7259355T>C	uc002ggh.1	+	4	342	c.315T>C	c.(313-315)TGT>TGC	p.C105C	TMEM95_uc002ggf.1_Silent_p.C105C|TMEM95_uc002ggg.1_Silent_p.C105C	NM_198154	NP_937797	Q3KNT9	TMM95_HUMAN	transmembrane protein 95	105	Extracellular (Potential).					integral to membrane					0		Prostate(122;0.173)				CAGCTCTCTGTCCCCCCGCCT	0.592		NA									OREG0024137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	104					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	C	T	rs28934575		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			43	59					0	0	0	0
MYH13	8735	broad.mit.edu	37	17	10206785	10206785	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:10206785C>T	uc002gmk.1	-	38	5587	c.5497G>A	c.(5497-5499)GAA>AAA	p.E1833K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1833	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CTCTTCTGTTCCACATCAAGC	0.517		NA											74	106					0	0	0	0
LRRC48	83450	broad.mit.edu	37	17	17898417	17898417	+	Silent	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:17898417C>A	uc010vxd.1	+	9	1195	c.816C>A	c.(814-816)CTC>CTA	p.L272L	LRRC48_uc002gsa.2_Silent_p.L272L|LRRC48_uc010vxc.1_Silent_p.L272L|LRRC48_uc002gsb.2_Silent_p.L272L|LRRC48_uc010vxe.1_5'Flank	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	272						cytoplasm				pancreas(1)	1	all_neural(463;0.228)					TCGGTGAGCTCCTTGAGACAT	0.338		NA											25	21					3.8e-18	4.07e-18	1	0
MAP2K3	5606	broad.mit.edu	37	17	21208407	21208407	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:21208407C>T	uc002gys.2	+	9	1006	c.741C>T	c.(739-741)GTC>GTT	p.V247V	MAP2K3_uc002gyt.2_Silent_p.V218V|MAP2K3_uc002gyu.2_Silent_p.V218V	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	247	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GCTACAATGTCAAGTCCGACG	0.592		NA											25	125					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29220740	29220740	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:29220740G>A	uc002hfs.1	+	21	5215	c.4869G>A	c.(4867-4869)AAG>AAA	p.K1623K		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1623					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CAGAGACAAAGAAATCTATTC	0.393		NA											61	101					0	0	0	0
C17orf75	64149	broad.mit.edu	37	17	30661853	30661853	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:30661853C>G	uc002hhg.2	-	7	706	c.675G>C	c.(673-675)TTG>TTC	p.L225F		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	225					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			GAGTGTAACTCAAAGCCTATG	0.363		NA											10	21					0	0	0	0
C17orf75	64149	broad.mit.edu	37	17	30662447	30662447	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:30662447C>G	uc002hhg.2	-	6	595	c.564G>C	c.(562-564)GAG>GAC	p.E188D		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	188					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTATGTGACTCTCCAGGCCCC	0.398		NA											27	150					0	0	0	0
LIG3	3980	broad.mit.edu	37	17	33316674	33316674	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:33316674C>T	uc002hik.1	+	4	989	c.881C>T	c.(880-882)TCA>TTA	p.S294L	LIG3_uc002hii.2_Missense_Mutation_p.S294L|LIG3_uc002hij.2_Missense_Mutation_p.S294L|LIG3_uc010cth.1_Missense_Mutation_p.S303L	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	294					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	CGGAAAGGCTCAGCAGGAGGT	0.423		NA						Other_BER_factors					21	98					0	0	0	0
PLXDC1	57125	broad.mit.edu	37	17	37264415	37264415	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:37264415C>T	uc002hrg.2	-	5	765	c.553G>A	c.(553-555)GGC>AGC	p.G185S	uc002hrf.1_3'UTR|PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	185	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						TCGGAGTAGCCAGGGTTGAAG	0.522		NA											51	107					0	0	0	0
MSL1	339287	broad.mit.edu	37	17	38285648	38285648	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:38285648G>C	uc002hub.2	+	3	559	c.540G>C	c.(538-540)TTG>TTC	p.L180F	MSL1_uc002hua.3_Missense_Mutation_p.L118F|MSL1_uc002huc.2_Missense_Mutation_p.L118F|MSL1_uc002hud.2_5'Flank	NM_001012241	NP_001012241	Q68DK7	MSL1_HUMAN	hampin	381					histone H4-K16 acetylation	MSL complex					0						AACGTGAATTGAGGAGCCAAG	0.473		NA											19	109					0	0	0	0
TOP2A	7153	broad.mit.edu	37	17	38567942	38567942	+	Silent	SNP	T	T	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:38567942T>C	uc002huq.2	-	8	1044	c.918A>G	c.(916-918)AAA>AAG	p.K306K	TOP2A_uc002hur.1_5'Flank	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	306					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GCTGAAAGCCTTTTTCACTCA	0.318		NA											3	93					0	0	0	0
DHX8	1659	broad.mit.edu	37	17	41599574	41599574	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:41599574C>T	uc002idu.1	+	22	3496	c.3423C>T	c.(3421-3423)CTC>CTT	p.L1141L	DHX8_uc010wig.1_Silent_p.L1141L	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1141						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CCAGTGCCCTCTTCAACAGAC	0.512		NA											14	57					0	0	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43517535	43517535	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:43517535G>A	uc002ija.2	-	10	3065	c.2895C>T	c.(2893-2895)CTC>CTT	p.L965L	PLEKHM1_uc010wjm.1_Silent_p.L937L|PLEKHM1_uc002ijb.2_Silent_p.L440L|PLEKHM1_uc010wjn.1_Silent_p.L914L	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	965					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					TTACCTGTTGGAGGTCAGCAA	0.473		NA											16	105					0	0	0	0
LPO	4025	broad.mit.edu	37	17	56342211	56342211	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:56342211C>G	uc002ivt.2	+	10	1711	c.1395C>G	c.(1393-1395)CGC>CGG	p.R465R	LPO_uc010wns.1_Silent_p.R406R|LPO_uc010dcp.2_Silent_p.R382R|LPO_uc010dcq.2_Silent_p.R136R|LPO_uc010dcr.2_Silent_p.R28R	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	465					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						TCGCCTTCCGCTTTGGCCACT	0.517		NA											15	103					0	0	0	0
RNF43	54894	broad.mit.edu	37	17	56440747	56440747	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:56440747C>T	uc002iwf.2	-	4	2427	c.471G>A	c.(469-471)CTG>CTA	p.L157L	RNF43_uc010wnv.1_Silent_p.L116L|RNF43_uc002iwh.3_Silent_p.L157L|RNF43_uc002iwg.3_Silent_p.L157L|RNF43_uc010dcw.2_Silent_p.L30L	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	157	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGGCCAGGTCAGCCCCAGCG	0.567		NA											17	165					0	0	0	0
KPNA2	3838	broad.mit.edu	37	17	66033573	66033573	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:66033573G>A	uc002jgk.2	+	3	307	c.175G>A	c.(175-177)GAT>AAT	p.D59N	KPNA2_uc002jgl.2_Missense_Mutation_p.D59N	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	59	IBB.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATTTCCTGATGATGCTACTTC	0.423		NA											65	78					0	0	0	0
ABCA10	10349	broad.mit.edu	37	17	67150091	67150091	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:67150091G>A	uc010dfa.1	-	33	4725	c.3846C>T	c.(3844-3846)TTC>TTT	p.F1282F	ABCA10_uc010wqs.1_Silent_p.F274F|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1282	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AGTACCCCAAGAACTTGAGGC	0.478		NA											27	124					0	0	0	0
FAM104A	84923	broad.mit.edu	37	17	71228289	71228289	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:71228289G>A	uc002jji.3	-	1	245	c.157C>T	c.(157-159)CTT>TTT	p.L53F	FAM104A_uc002jjj.3_Missense_Mutation_p.L53F|C17orf80_uc010wqu.1_5'Flank|C17orf80_uc010dfj.2_5'Flank|C17orf80_uc002jjk.1_5'Flank|C17orf80_uc002jjm.3_5'Flank|C17orf80_uc002jjl.3_5'Flank	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	53											0			LUSC - Lung squamous cell carcinoma(166;0.197)			GCTCCGCGAAGAGAGGGAACA	0.701		NA											4	32					0	0	0	0
CD300A	11314	broad.mit.edu	37	17	72469964	72469964	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:72469964C>T	uc002jkv.2	+	2	651	c.330C>T	c.(328-330)CTC>CTT	p.L110L	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	110	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						CACCATGGCTCCGAGACTTTC	0.562		NA											12	109					0	0	0	0
GALR2	8811	broad.mit.edu	37	17	74071153	74071153	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74071153C>T	uc002jqm.1	+	1	270	c.189C>T	c.(187-189)TTC>TTT	p.F63F	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	63	Helical; Name=2; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						CCAACCTGTTCATCCTTAACC	0.652		NA											11	70					0	0	0	0
GALR2	8811	broad.mit.edu	37	17	74071276	74071276	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74071276C>T	uc002jqm.1	+	1	393	c.312C>T	c.(310-312)CTC>CTT	p.L104L	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	104	Helical; Name=3; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						TGCACTTCCTCATCTTCCTCA	0.647		NA											14	70					0	0	0	0
ZACN	353174	broad.mit.edu	37	17	74077658	74077658	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74077658C>G	uc002jqn.2	+	7	785	c.702C>G	c.(700-702)ATC>ATG	p.I234M	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_Intron|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqs.2_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	234	Leu-rich.|Helical; Name=1; (Potential).				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						TCAAGTCCATCATCGCTCTCT	0.642		NA											4	175					0	0	0	0
RHBDF2	79651	broad.mit.edu	37	17	74475233	74475233	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:74475233C>T	uc002jrq.1	-	5	779	c.486G>A	c.(484-486)CTG>CTA	p.L162L	RHBDF2_uc002jrp.1_Silent_p.L133L|RHBDF2_uc002jrr.1_Silent_p.L14L|RHBDF2_uc010wtf.1_Silent_p.L133L|RHBDF2_uc002jrs.1_Silent_p.L133L	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	162	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						TGGGGAGCTCCAGGTCACGCT	0.692		NA											11	77					0	0	0	0
SEPT9	10801	broad.mit.edu	37	17	75398526	75398526	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:75398526C>T	uc002jts.3	+	3	588	c.462C>T	c.(460-462)ATC>ATT	p.I154I	SEPT9_uc010wtk.1_Silent_p.I135I|SEPT9_uc002jtt.3_5'UTR|SEPT9_uc002jtu.3_Silent_p.I136I|SEPT9_uc002jtv.2_Silent_p.I147I|SEPT9_uc002jtw.2_5'UTR|SEPT9_uc002jtx.1_5'UTR|SEPT9_uc010wtl.1_5'Flank	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	154					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			AGATCACCATCGTCAAACCCC	0.706		NA											8	13					0	0	0	0
NPTX1	4884	broad.mit.edu	37	17	78449452	78449452	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:78449452C>G	uc002jyp.1	-	2	669	c.511G>C	c.(511-513)GAT>CAT	p.D171H		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	171					central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			TCCAGCTCATCGATCTTGCTC	0.637		NA											17	48					0	0	0	0
AATK	9625	broad.mit.edu	37	17	79094803	79094803	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:79094803C>T	uc010dia.2	-	11	3013	c.2933G>A	c.(2932-2934)CGG>CAG	p.R978Q	AATK_uc010dhz.2_Intron	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	978						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GGTGGAGAGCCGTGTCTCGGG	0.652		NA											4	24					0	0	0	0
FASN	2194	broad.mit.edu	37	17	80054216	80054216	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:80054216C>T	uc002kdu.2	-	2	223	c.106G>A	c.(106-108)GAT>AAT	p.D36N		NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	36	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGACGGTCATCGTCCGTGACC	0.632		NA											12	92					0	0	0	0
CCDC57	284001	broad.mit.edu	37	17	80141798	80141798	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr17:80141798C>T	uc002kdz.1	-	9	1418	c.1063G>A	c.(1063-1065)GAT>AAT	p.D355N	CCDC57_uc002kdx.1_Missense_Mutation_p.D355N|CCDC57_uc010dik.1_5'UTR	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	355	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			GTTGATGCATCTTCACGAAGT	0.453		NA											24	32					0	0	0	0
LRRC30	339291	broad.mit.edu	37	18	7232012	7232012	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:7232012C>G	uc010wzk.1	+	1	876	c.876C>G	c.(874-876)TTC>TTG	p.F292L		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	292										ovary(1)|liver(1)	2						AGATGCTCTTCGGCTACCTGA	0.587		NA											66	137					0	0	0	0
ROCK1	6093	broad.mit.edu	37	18	18566941	18566941	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:18566941C>G	uc002kte.2	-	19	3215	c.2274G>C	c.(2272-2274)TTG>TTC	p.L758F		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	758	Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TATTTCCAGTCAAATGTTCTA	0.368		NA											8	111					0	0	0	0
ROCK1	6093	broad.mit.edu	37	18	18586476	18586476	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:18586476G>A	uc002kte.2	-	16	2662	c.1721C>T	c.(1720-1722)TCA>TTA	p.S574L		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	574	Interaction with FHOD1.|Potential.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CTGACTAATTGACTTGCTCAT	0.383		NA											44	121					0	0	0	0
ZNF521	25925	broad.mit.edu	37	18	22805754	22805754	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:22805754G>A	uc002kvk.2	-	4	2375	c.2128C>T	c.(2128-2130)CAG>TAG	p.Q710*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.Q710*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.Q490*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	710	C2H2-type 16.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGGTGTTTCTGAAGGTCATCC	0.443		NA	T	PAX5	ALL								24	101					0	0	0	0
ZNF397OS	100101467	broad.mit.edu	37	18	32843968	32843968	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:32843968C>G	uc002kym.2	-	2	577	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	ZNF397_uc010dmr.2_Intron|ZNF397OS_uc010xce.1_Missense_Mutation_p.E117Q|ZNF397OS_uc002kyn.1_Missense_Mutation_p.E117Q	NM_001112734	NP_001106205	Q86W11	ZSC30_HUMAN	zinc finger protein 397 opposite strand	117	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACAGCTTCCTCTCCATTCTCT	0.498		NA											11	70					0	0	0	0
KATNAL2	83473	broad.mit.edu	37	18	44595607	44595607	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:44595607C>T	uc002lco.2	+	9	820	c.626C>T	c.(625-627)ACA>ATA	p.T209I	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Missense_Mutation_p.T136I	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	281						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						CAGCTATTTACAGGAATTCTT	0.463		NA											25	94					0	0	0	0
CTDP1	9150	broad.mit.edu	37	18	77474881	77474881	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr18:77474881C>G	uc002lnh.1	+	8	1568	c.1421C>G	c.(1420-1422)TCT>TGT	p.S474C	CTDP1_uc002lni.1_Missense_Mutation_p.S474C|CTDP1_uc010drd.1_Missense_Mutation_p.S474C	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	474	Ser-rich.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		TCCTCCGCCTCTGATGGCGAA	0.677		NA											2	4					0	0	0	0
SHC2	25759	broad.mit.edu	37	19	422154	422154	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:422154C>T	uc002loq.3	-	11	1612	c.1612G>A	c.(1612-1614)GAG>AAG	p.E538K	SHC2_uc002lop.3_Missense_Mutation_p.E279K	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	538	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCACGCCCTCGGGGTCCACG	0.687		NA											5	10					0	0	0	0
POLRMT	5442	broad.mit.edu	37	19	621366	621366	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:621366C>A	uc002lpf.1	-	10	2388	c.2332G>T	c.(2332-2334)GAG>TAG	p.E778*		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	778					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACAGCGCCTCCGCCCGCAGG	0.746		NA											4	10					0.00909568	0.00923134	1	0
MEX3D	399664	broad.mit.edu	37	19	1556393	1556393	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:1556393C>G	uc010dsn.2	-	2	1125	c.1125G>C	c.(1123-1125)AAG>AAC	p.K375N		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	375					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTTGGGGGTCTTGGCCCAGA	0.776		NA											3	9					0	0	0	0
TCF3	6929	broad.mit.edu	37	19	1621849	1621849	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:1621849C>T	uc002ltr.2	-	11	1010	c.943G>A	c.(943-945)GAC>AAC	p.D315N	TCF3_uc002lto.2_Missense_Mutation_p.D77N|TCF3_uc002ltt.3_Missense_Mutation_p.D315N|TCF3_uc002ltq.2_Missense_Mutation_p.D264N|TCF3_uc002lts.1_Missense_Mutation_p.D231N|TCF3_uc010dso.1_5'Flank	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12	315					B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAGGCTGTCGGCCCCGCTG	0.711		NA	T	PBX1|HLF|TFPT	pre B-ALL								3	14					0	0	0	0
REXO1	57455	broad.mit.edu	37	19	1818554	1818554	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:1818554G>A	uc002lua.3	-	10	3038	c.2943C>T	c.(2941-2943)CTC>CTT	p.L981L	REXO1_uc010dsq.2_Silent_p.L290L|REXO1_uc010xgs.1_5'UTR|MIR1909_hsa-mir-1909|MI0008330_5'Flank|REXO1_uc010dsp.1_RNA	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	981						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGAGGACACGAGGTACTCGG	0.672		NA											3	18					0	0	0	0
DIRAS1	148252	broad.mit.edu	37	19	2717417	2717417	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:2717417C>T	uc002lwf.3	-	2	546	c.388G>A	c.(388-390)GTG>ATG	p.V130M		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	130					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCGTGTCCACCTCCCGCTGC	0.617		NA											15	32					0	0	0	0
MAP2K2	5605	broad.mit.edu	37	19	4099284	4099284	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:4099284G>C	uc002lzk.2	-	7	1088	c.834C>G	c.(832-834)ATC>ATG	p.I278M	MAP2K2_uc002lzj.2_Missense_Mutation_p.I88M	NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	278	Protein kinase.|Pro-rich.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGGCCAAAGATGGCCTCCA	0.697		NA							Cardiofaciocutaneous_syndrome				3	13					0	0	0	0
SAFB	6294	broad.mit.edu	37	19	5664440	5664440	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:5664440G>A	uc002mcf.2	+	17	2377	c.2324G>A	c.(2323-2325)CGA>CAA	p.R775Q	SAFB_uc002mcg.2_Missense_Mutation_p.R775Q|SAFB_uc002mce.3_Missense_Mutation_p.R774Q|SAFB_uc010xir.1_Missense_Mutation_p.R774Q|SAFB_uc010xis.1_Missense_Mutation_p.R706Q|SAFB_uc010xit.1_Missense_Mutation_p.R617Q|SAFB_uc010xiu.1_Missense_Mutation_p.R574Q	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	775	Interaction with SAFB2.|Interaction with POLR2A.|Arg-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		ATGGGAGAACGAGAAGGACAG	0.458		NA											5	36					0	0	0	0
DENND1C	79958	broad.mit.edu	37	19	6471307	6471307	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:6471307C>T	uc002mfe.2	-	17	1351	c.1259G>A	c.(1258-1260)CGA>CAA	p.R420Q	DENND1C_uc002mfb.2_5'UTR|DENND1C_uc002mfc.2_5'UTR|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.R376Q	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	420						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						CTGATAGGATCGAAGGGCCCC	0.463		NA											7	11					0	0	0	0
COL5A3	50509	broad.mit.edu	37	19	10085036	10085036	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10085036G>T	uc002mmq.1	-	46	3477	c.3391C>A	c.(3391-3393)CAG>AAG	p.Q1131K		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1131	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TCTCCTTTCTGCCCAAAGAGG	0.542		NA											14	38					1.5e-05	1.55e-05	1	0
EIF3G	8666	broad.mit.edu	37	19	10226446	10226446	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10226446C>G	uc002mnd.2	-	9	818	c.754G>C	c.(754-756)GAG>CAG	p.E252Q		NM_003755	NP_003746	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3,	252	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			AGGTCGGTCTCACGCGTGTCC	0.637		NA											44	87					0	0	0	0
ICAM1	3383	broad.mit.edu	37	19	10395703	10395703	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10395703C>T	uc002mnq.2	+	6	1744	c.1425C>T	c.(1423-1425)CTC>CTT	p.L475L	ICAM1_uc010xle.1_Silent_p.L253L|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	475	Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	TGAATGTGCTCTGTGAGTGAG	0.622		NA											15	37					0	0	0	0
ICAM5	7087	broad.mit.edu	37	19	10402810	10402810	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:10402810C>T	uc002mnu.3	+	4	838	c.773C>T	c.(772-774)TCA>TTA	p.S258L	ICAM5_uc002mnv.3_Missense_Mutation_p.S133L	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	258	Extracellular (Potential).|Ig-like C2-type 3.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			TTTCCAGCCTCAGAGGCCAGG	0.647		NA											6	111					0	0	0	0
DOCK6	57572	broad.mit.edu	37	19	11354276	11354276	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:11354276C>T	uc002mqs.3	-	11	1256	c.1215G>A	c.(1213-1215)GTG>GTA	p.V405V		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	405					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CAGCGCTGCTCACGATGTTGG	0.692		NA									OREG0025252	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	17					0	0	0	0
ZNF625	90589	broad.mit.edu	37	19	12256165	12256165	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:12256165C>T	uc002mth.2	-	4	1218	c.868G>A	c.(868-870)GAA>AAA	p.E290K	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Missense_Mutation_p.E324K	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGGGTTTTTCTCCAGTGTGA	0.428		NA											39	72					0	0	0	0
TRMT1	55621	broad.mit.edu	37	19	13226280	13226280	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:13226280C>T	uc002mwj.2	-	4	704	c.454G>A	c.(454-456)GAA>AAA	p.E152K	NACC1_uc002mwm.2_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.E152K|TRMT1_uc002mwl.3_Missense_Mutation_p.E152K|TRMT1_uc010xmz.1_5'UTR	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	152							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TGCAGGCCTTCCTGTTGGAGT	0.587		NA											8	29					0	0	0	0
OR10H4	126541	broad.mit.edu	37	19	16060070	16060070	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:16060070G>A	uc010xov.1	+	1	253	c.253G>A	c.(253-255)GAT>AAT	p.D85N		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CATGCTGGCTGATCTGCTTTC	0.507		NA											6	349					0	0	0	0
ZNF486	90649	broad.mit.edu	37	19	20307969	20307969	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:20307969G>C	uc002nou.2	+	4	507	c.450G>C	c.(448-450)CAG>CAC	p.Q150H		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAACTACCCAGAGCAAAATAT	0.303		NA											33	95					0	0	0	0
ZNF91	7644	broad.mit.edu	37	19	23544945	23544945	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:23544945G>A	uc002nre.2	-	4	949	c.836C>T	c.(835-837)TCA>TTA	p.S279L	ZNF91_uc010xrj.1_Missense_Mutation_p.S247L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	279	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTTAGGGTTGAGGACCATAG	0.388		NA											11	83					0	0	0	0
CATSPERG	57828	broad.mit.edu	37	19	38853162	38853162	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:38853162C>T	uc002oih.3	+	19	2391	c.2304C>T	c.(2302-2304)TTC>TTT	p.F768F	CATSPERG_uc002oig.3_Silent_p.F728F|CATSPERG_uc002oif.3_Silent_p.F408F|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	768	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane		p.S768F(1)		ovary(1)|skin(1)	2						AGTACAGCTTCGCCATCTTCC	0.612		NA											9	54					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40368869	40368869	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:40368869C>T	uc002omp.3	-	28	12487	c.12479G>A	c.(12478-12480)GGT>GAT	p.G4160D		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4160	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGTGAGCACACCGTTCACCTG	0.637		NA											25	217					0	0	0	0
GSK3A	2931	broad.mit.edu	37	19	42737444	42737444	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:42737444G>A	uc002otb.1	-	7	1115	c.996C>T	c.(994-996)ATC>ATT	p.I332I	GSK3A_uc002ota.1_Silent_p.I250I|GSK3A_uc002otc.2_RNA	NM_019884	NP_063937	P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	332	Protein kinase.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)				TCACCTTGATGATCTCCACCA	0.642		NA											4	10					0	0	0	0
GEMIN7	79760	broad.mit.edu	37	19	45593559	45593559	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:45593559C>T	uc002pap.1	+	3	338	c.187C>T	c.(187-189)CGG>TGG	p.R63W	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Missense_Mutation_p.R63W|GEMIN7_uc002par.1_Missense_Mutation_p.R63W	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	63					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		AGCCGCCCTTCGGGAGCGTTA	0.632		NA											4	57					0	0	0	0
PPM1N	147699	broad.mit.edu	37	19	46002055	46002055	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:46002055C>G	uc002pce.2	+	1	325	c.325C>G	c.(325-327)CGA>GGA	p.R109G	RTN2_uc002pcb.2_5'Flank|RTN2_uc002pcc.2_5'Flank|RTN2_uc002pcd.2_5'Flank|PPM1N_uc002pcf.2_5'Flank	NM_001080401	NP_001073870	Q8N819	PPM1N_HUMAN	protein phosphatase 1B-like	109	PP2C-like.						magnesium ion binding|manganese ion binding|phosphoprotein phosphatase activity				0						CGGTGGGGCTCGAGCTGCCCG	0.711		NA											2	3					0	0	0	0
STRN4	29888	broad.mit.edu	37	19	47226133	47226133	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:47226133C>T	uc002pfl.2	-	14	1873	c.1840G>A	c.(1840-1842)GAC>AAC	p.D614N	STRN4_uc002pfm.2_Missense_Mutation_p.D621N|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	614	WD 4.					cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		AAGACGGTGTCGCCAGAGCGG	0.637		NA											29	99					0	0	0	0
SLC1A5	6510	broad.mit.edu	37	19	47278850	47278850	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:47278850C>T	uc002pfs.2	-	8	2163	c.1543G>A	c.(1543-1545)GAG>AAG	p.E515K	SLC1A5_uc010xyh.1_Missense_Mutation_p.E313K|SLC1A5_uc002pfq.2_Missense_Mutation_p.E339K|SLC1A5_uc002pfr.2_Missense_Mutation_p.E287K	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	515					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	TTTCCTTCCTCAGTGGGGACT	0.582		NA											53	201					0	0	0	0
EHD2	30846	broad.mit.edu	37	19	48229328	48229328	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:48229328C>T	uc002phj.3	+	4	1012	c.762C>T	c.(760-762)ATC>ATT	p.I254I	EHD2_uc010xyu.1_Silent_p.I118I|EHD2_uc010xyv.1_5'Flank	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	254					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		GCGTCTACATCGGCTCCTTCT	0.697		NA											6	6					0	0	0	0
MYH14	79784	broad.mit.edu	37	19	50721024	50721024	+	Silent	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:50721024G>T	uc002prr.1	+	3	605	c.558G>T	c.(556-558)CTG>CTT	p.L186L	MYH14_uc010enu.1_Silent_p.L186L|MYH14_uc002prq.1_Silent_p.L186L	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	186	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGAGCATGCTGCAGGGTGAGT	0.642		NA											29	57					7.01e-11	7.41e-11	1	0
SIGLEC8	27181	broad.mit.edu	37	19	51958028	51958028	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:51958028G>C	uc002pwt.2	-	5	1125	c.1058C>G	c.(1057-1059)TCA>TGA	p.S353*	SIGLEC8_uc010yda.1_Nonsense_Mutation_p.S244*|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Nonsense_Mutation_p.S260*	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	353	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TACAGGTCTTGAGGTGCCTGC	0.547		NA											11	97					0	0	0	0
ZNF350	59348	broad.mit.edu	37	19	52468574	52468574	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:52468574C>G	uc002pyd.2	-	5	1360	c.1132G>C	c.(1132-1134)GAA>CAA	p.E378Q	uc002pyb.2_Intron|uc002pyc.2_Intron	NM_021632	NP_067645	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	378	C2H2-type 7.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(1)	1		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		TTCCCACATTCACTACATTCA	0.433		NA											11	43					0	0	0	0
ZNF615	284370	broad.mit.edu	37	19	52497896	52497896	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:52497896T>A	uc002pye.1	-	6	725	c.433A>T	c.(433-435)AAC>TAC	p.N145Y	ZNF615_uc002pyf.1_Missense_Mutation_p.N156Y|ZNF615_uc002pyg.1_Missense_Mutation_p.N37Y|ZNF615_uc002pyh.1_Missense_Mutation_p.N156Y|ZNF615_uc010epi.1_Missense_Mutation_p.N152Y|ZNF615_uc010ydg.1_Missense_Mutation_p.N150Y	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CTTTTCTGGTTTTCAAAACTT	0.318		NA											8	87					0	0	0	0
OSCAR	126014	broad.mit.edu	37	19	54600369	54600369	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:54600369C>G	uc002qdd.2	-	4	345	c.228G>C	c.(226-228)TTG>TTC	p.L76F	OSCAR_uc002qcy.2_Missense_Mutation_p.L55F|OSCAR_uc002qcz.2_Missense_Mutation_p.L51F|OSCAR_uc002qda.2_Missense_Mutation_p.L55F|OSCAR_uc002qdb.2_Missense_Mutation_p.L40F|OSCAR_uc010erc.2_Missense_Mutation_p.E19Q|OSCAR_uc002qdc.2_Missense_Mutation_p.L65F	NM_206818	NP_996554	Q8IYS5	OSCAR_HUMAN	osteoclast-associated receptor isoform 1	51	Ig-like 1.					extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)					CCCGGCATCTCAAGGTCACGT	0.592		NA											28	122					0	0	0	0
NLRP5	126206	broad.mit.edu	37	19	56539850	56539850	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:56539850G>A	uc002qmj.2	+	7	2251	c.2251G>A	c.(2251-2253)GAG>AAG	p.E751K	NLRP5_uc002qmi.2_Missense_Mutation_p.E732K	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	751	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGAGTCCGCTGAGGCATGTCC	0.522		NA											58	202					0	0	0	0
USP29	57663	broad.mit.edu	37	19	57642360	57642360	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:57642360G>A	uc002qny.2	+	4	2673	c.2317G>A	c.(2317-2319)GAA>AAA	p.E773K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	773					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCAGTCTACAGAATTAAGACT	0.463		NA											17	24					0	0	0	0
TRIM28	10155	broad.mit.edu	37	19	59060728	59060728	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr19:59060728C>A	uc002qtg.1	+	13	1982	c.1693C>A	c.(1693-1695)CCT>ACT	p.P565T	TRIM28_uc010eut.1_Missense_Mutation_p.P483T|TRIM28_uc002qth.1_Missense_Mutation_p.P180T	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein	565					epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CATTGGAGCCCCTCCTACTGC	0.607		NA											53	195					6.57e-35	7.08e-35	1	0
RSAD2	91543	broad.mit.edu	37	2	7023543	7023543	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:7023543C>G	uc002qyp.1	+	2	524	c.388C>G	c.(388-390)CAA>GAA	p.Q130E		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	130					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		GCCATTTCTTCAAGACCGGGG	0.453		NA											12	88					0	0	0	0
ADAM17	6868	broad.mit.edu	37	2	9630344	9630344	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:9630344G>A	uc002qzu.2	-	19	2620	c.2437C>T	c.(2437-2439)CGT>TGT	p.R813C	IAH1_uc010yiz.1_Intron|ADAM17_uc010ewy.2_Missense_Mutation_p.R796C|ADAM17_uc010ewz.2_Missense_Mutation_p.R156C	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	813	Cytoplasmic (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CGATTCTGACGCTGCAGTTTA	0.438		NA											5	67					0	0	0	0
TRIB2	28951	broad.mit.edu	37	2	12858450	12858450	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:12858450C>G	uc002rbv.3	+	1	1453	c.17C>G	c.(16-18)TCT>TGT	p.S6C	TRIB2_uc010yjp.1_Intron	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	6					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATACACAGGTCTACCCCCATC	0.537		NA									OREG0014450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	62					0	0	0	0
APOB	338	broad.mit.edu	37	2	21226113	21226113	+	Missense_Mutation	SNP	C	C	T	rs121918385		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:21226113C>T	uc002red.2	-	29	12309	c.12181G>A	c.(12181-12183)GAG>AAG	p.E4061K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4061					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAAGCTGCCTCTTCTTCCCAA	0.453		NA											107	295					0	0	0	0
ATAD2B	54454	broad.mit.edu	37	2	23980730	23980730	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:23980730G>A	uc002rek.3	-	25	3930	c.3636C>T	c.(3634-3636)ATC>ATT	p.I1212I	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Silent_p.I452I|ATAD2B_uc002rej.3_Silent_p.I380I	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1212							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAAGTCCATGATGTCACAGG	0.443		NA											31	101					0	0	0	0
C2orf44	80304	broad.mit.edu	37	2	24255769	24255769	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:24255769G>A	uc002rep.2	-	3	1997	c.1866C>T	c.(1864-1866)CTC>CTT	p.L622L	C2orf44_uc010eya.2_Intron	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	622							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACCATCACAGAGAAGCACCG	0.383		NA											46	151					0	0	0	0
TMEM214	54867	broad.mit.edu	37	2	27263361	27263361	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27263361G>A	uc002ria.3	+	16	2050	c.1940G>A	c.(1939-1941)TGC>TAC	p.C647Y	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.C602Y	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	647						integral to membrane	protein binding				0						CATGAGGCATGCAGGTGAGAC	0.637		NA											5	56					0	0	0	0
GTF3C2	2976	broad.mit.edu	37	2	27566224	27566224	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566224C>G	uc002rjv.1	-	3	561	c.198G>C	c.(196-198)CAG>CAC	p.Q66H	GTF3C2_uc002rju.1_Missense_Mutation_p.Q77H|GTF3C2_uc002rjw.1_Missense_Mutation_p.Q66H|GTF3C2_uc010eyz.1_Missense_Mutation_p.Q66H	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	66						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGCCTCCTCTGATCAGGAG	0.488		NA											9	282					0	0	0	0
GTF3C2	2976	broad.mit.edu	37	2	27566241	27566241	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566241C>G	uc002rjv.1	-	3	544	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	GTF3C2_uc002rju.1_Missense_Mutation_p.E72Q|GTF3C2_uc002rjw.1_Missense_Mutation_p.E61Q|GTF3C2_uc010eyz.1_Missense_Mutation_p.E61Q	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	61						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGAATCCTCAAATCCAGGC	0.488		NA											5	260					0	0	0	0
GTF3C2	2976	broad.mit.edu	37	2	27566274	27566274	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566274C>G	uc002rjv.1	-	3	511	c.148G>C	c.(148-150)GAG>CAG	p.E50Q	GTF3C2_uc002rju.1_Missense_Mutation_p.E61Q|GTF3C2_uc002rjw.1_Missense_Mutation_p.E50Q|GTF3C2_uc010eyz.1_Missense_Mutation_p.E50Q	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	50						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATGACATCTCTACGGAAGCC	0.522		NA											5	254					0	0	0	0
GTF3C2	2976	broad.mit.edu	37	2	27566301	27566301	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:27566301C>A	uc002rjv.1	-	3	484	c.121G>T	c.(121-123)GAA>TAA	p.E41*	GTF3C2_uc002rju.1_Nonsense_Mutation_p.E52*|GTF3C2_uc002rjw.1_Nonsense_Mutation_p.E41*|GTF3C2_uc010eyz.1_Nonsense_Mutation_p.E41*	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	41						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGTCATTTCTGAAGAGGTC	0.542		NA											6	239					2.53e-12	2.69e-12	1	0
SPDYA	245711	broad.mit.edu	37	2	29063067	29063067	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:29063067C>T	uc002rmj.2	+	7	788	c.582C>T	c.(580-582)ATC>ATT	p.I194I	SPDYA_uc002rmi.2_Silent_p.I194I|SPDYA_uc002rmk.2_Silent_p.I194I|SPDYA_uc002rml.2_Silent_p.I194I	NM_182756	NP_877433	Q5MJ70	SPDYA_HUMAN	speedy homolog A isoform 1	194	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			upper_aerodigestive_tract(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					CCCATTATATCTGGCAAAGAG	0.378		NA											7	37					0	0	0	0
C2orf71	388939	broad.mit.edu	37	2	29294902	29294902	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:29294902C>T	uc002rmt.1	-	1	2226	c.2226G>A	c.(2224-2226)GAG>GAA	p.E742E		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	742					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						TCCTCAGACTCTCCGTGGGAC	0.562		NA											27	65					0	0	0	0
XDH	7498	broad.mit.edu	37	2	31598258	31598258	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:31598258C>T	uc002rnv.1	-	15	1669	c.1590G>A	c.(1588-1590)GAG>GAA	p.E530E		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	530					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTTCCAGGTTCTCTTGGCCCA	0.552		NA											39	120					0	0	0	0
CCDC75	253635	broad.mit.edu	37	2	37319076	37319076	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:37319076C>T	uc010ezz.2	+	5	479	c.334C>T	c.(334-336)CAT>TAT	p.H112Y	CCDC75_uc002rpr.3_Missense_Mutation_p.H9Y	NM_174931	NP_777591	Q8N954	CCD75_HUMAN	coiled-coil domain containing 75	112	G-patch.					intracellular	nucleic acid binding				0		all_hematologic(82;0.21)				TGGCATTGGTCATGAGGCATC	0.348		NA											9	36					0	0	0	0
CDKL4	344387	broad.mit.edu	37	2	39406448	39406448	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:39406448C>T	uc002rrm.2	-	8	807	c.807G>A	c.(805-807)ATG>ATA	p.M269I	CDKL4_uc010fal.1_Missense_Mutation_p.M269I	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	269	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				CATCTGGATTCATCTTCAGAC	0.423		NA											14	90					0	0	0	0
LOC728819	728819	broad.mit.edu	37	2	43902889	43902889	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:43902889C>T	uc010fav.1	-	1	573	c.573G>A	c.(571-573)TTG>TTA	p.L191L	PLEKHH2_uc002rte.3_Intron|PLEKHH2_uc002rtf.3_Intron|PLEKHH2_uc010yny.1_Intron	NM_001101330	NP_001094800			C1GALT1-specific chaperone 1-like												0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTCTTTTCATCAACTCTCTGC	0.448		NA											53	167					0	0	0	0
SIX3	6496	broad.mit.edu	37	2	45169452	45169453	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:45169452_45169453CC>AT	uc002run.1	+	1	416_417	c.209_210CC>AT	c.(208-210)TCC>TAT	p.S70Y		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	70					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ggcggcggcTCCAGGGCCCCCC	0.342		NA											4	9					0	0	0	0
RHOQ	23433	broad.mit.edu	37	2	46770215	46770215	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:46770215C>T	uc002rva.2	+	1	349	c.30C>T	c.(28-30)CTC>CTT	p.L10L	ATP6V1E2_uc002ruz.2_5'Flank	NM_012249	NP_036381	P17081	RHOQ_HUMAN	ras-like protein TC10 precursor	10					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CGCTGATGCTCAAGTGCGTGG	0.587		NA											6	49					0	0	0	0
SOCS5	9655	broad.mit.edu	37	2	46986870	46986870	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:46986870G>T	uc002rvf.2	+	2	1365	c.1201G>T	c.(1201-1203)GGC>TGC	p.G401C	SOCS5_uc010yoe.1_Missense_Mutation_p.G370C|SOCS5_uc002rvg.2_Missense_Mutation_p.G401C	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	401	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GAAACCTGAAGGCACGTTTTT	0.527		NA											26	78					7.93e-12	8.42e-12	1	0
FBXO11	80204	broad.mit.edu	37	2	48063095	48063095	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:48063095C>T	uc010fbl.2	-	5	495	c.381G>A	c.(379-381)ATG>ATA	p.M127I	FBXO11_uc002rwe.2_Missense_Mutation_p.M127I|FBXO11_uc002rwf.2_Missense_Mutation_p.M127I|FBXO11_uc002rwg.1_Missense_Mutation_p.M127I	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	211					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTTCAGGATGCATCATAGGGC	0.328		NA											7	54					0	0	0	0
SPTBN1	6711	broad.mit.edu	37	2	54852072	54852072	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:54852072G>A	uc002rxu.2	+	11	1563	c.1314G>A	c.(1312-1314)CTG>CTA	p.L438L	SPTBN1_uc002rxv.1_Silent_p.L438L|SPTBN1_uc002rxx.2_Silent_p.L425L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	438	Spectrin 2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGACTTGGCTGAGCGAAAACC	0.488		NA											6	102					0	0	0	0
MTIF2	4528	broad.mit.edu	37	2	55471167	55471167	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:55471167C>G	uc002ryn.2	-	12	2046	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q	MTIF2_uc010yox.1_Missense_Mutation_p.E106Q|MTIF2_uc002ryo.2_Missense_Mutation_p.E437Q	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	437					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						TGATACACCTCAGATTCTACT	0.338		NA											7	31					0	0	0	0
CCDC104	112942	broad.mit.edu	37	2	55747049	55747049	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:55747049G>A	uc002ryy.2	+	1	310	c.112G>A	c.(112-114)GAA>AAA	p.E38K	CCDC104_uc002ryx.2_Missense_Mutation_p.E38K	NM_080667	NP_542398	Q96G28	CC104_HUMAN	coiled-coil domain containing 104	38										ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACAGAAATGTGAAGGTAAAAA	0.567		NA											26	50					0	0	0	0
ETAA1	54465	broad.mit.edu	37	2	67630409	67630409	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:67630409G>C	uc002sdz.1	+	5	734	c.595G>C	c.(595-597)GAT>CAT	p.D199H		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	199	Potential.					cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						TAAACAATTTGATAAAAATAT	0.259		NA											29	65					0	0	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043679	71043679	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:71043679C>A	uc002shf.2	-	4	911	c.834G>T	c.(832-834)TTG>TTT	p.L278F	CLEC4F_uc010yqv.1_Missense_Mutation_p.L278F	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	278	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TGGCTCCTTCCAAACTATTTC	0.408		NA											32	114					3.99e-17	4.28e-17	1	0
RAB11FIP5	26056	broad.mit.edu	37	2	73303223	73303223	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:73303223C>T	uc002siu.3	-	4	1897	c.1656G>A	c.(1654-1656)CTG>CTA	p.L552L	RAB11FIP5_uc002sis.3_5'UTR|RAB11FIP5_uc002sit.3_Silent_p.L474L	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	552					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GCCCACTGCTCAGGGCTATGC	0.622		NA											27	261					0	0	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73339833	73339833	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:73339833C>T	uc002siu.3	-	1	314	c.73G>A	c.(73-75)GTG>ATG	p.V25M		NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	25	C2.				protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GCCCGCAGCACCGTCACCTGG	0.751		NA											3	3					0	0	0	0
TPRKB	51002	broad.mit.edu	37	2	73959362	73959362	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:73959362G>C	uc002sjn.2	-	3	303	c.192C>G	c.(190-192)CTC>CTG	p.L64L	TPRKB_uc002sjm.2_Silent_p.L103L|TPRKB_uc002sjl.2_Silent_p.L31L|TPRKB_uc002sjo.2_Silent_p.L64L|TPRKB_uc010yrm.1_Silent_p.L31L	NM_016058	NP_057142	Q9Y3C4	TPRKB_HUMAN	TP53RK binding protein	64					protein catabolic process	cytosol|nucleus	protein kinase binding			ovary(1)|skin(1)	2						CCAGTTTGTAGAGGTGAACTG	0.358		NA											23	52					0	0	0	0
RTKN	6242	broad.mit.edu	37	2	74657432	74657432	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:74657432C>T	uc002sle.2	-	5	609	c.492G>A	c.(490-492)ATG>ATA	p.M164I	RTKN_uc002slc.2_Missense_Mutation_p.M151I|RTKN_uc002sld.2_Missense_Mutation_p.M114I	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	164					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						CCACTAGGATCATCTCTGTGT	0.547		NA											7	36					0	0	0	0
C2orf3	6936	broad.mit.edu	37	2	75929407	75929407	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:75929407C>G	uc002sno.2	-	3	667	c.537G>C	c.(535-537)GAG>GAC	p.E179D	C2orf3_uc010ffs.2_5'Flank|C2orf3_uc002snn.2_Missense_Mutation_p.E10D|C2orf3_uc010fft.2_5'UTR|C2orf3_uc002snp.3_Missense_Mutation_p.E179D	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	179					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CAGGCTCACTCTCAGGGTCAT	0.423		NA											40	120					0	0	0	0
LRRTM4	80059	broad.mit.edu	37	2	76975904	76975904	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:76975904C>G	uc002snr.2	-	4	2105	c.1690G>C	c.(1690-1692)GAG>CAG	p.E564Q	LRRTM4_uc002snq.2_Missense_Mutation_p.E564Q	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	564	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CGGCCCAGCTCCAGGCCGGGG	0.602		NA											32	121					0	0	0	0
ZNF514	84874	broad.mit.edu	37	2	95815860	95815860	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:95815860C>T	uc002sue.1	-	5	744	c.370G>A	c.(370-372)GAG>AAG	p.E124K	ZNF514_uc002sud.1_Missense_Mutation_p.E197K	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCTGCATCTCTAACTGGCCA	0.423		NA											40	82					0	0	0	0
ZNF514	84874	broad.mit.edu	37	2	95818421	95818421	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:95818421G>A	uc002sue.1	-	4	589	c.215C>T	c.(214-216)TCA>TTA	p.S72L	ZNF514_uc002sud.1_Missense_Mutation_p.S145L	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	72	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCACTCACCTGAGTGGGCTCC	0.522		NA											54	150					0	0	0	0
FER1L5	90342	broad.mit.edu	37	2	97361634	97361634	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:97361634G>C	uc010fia.2	+	35	4131	c.4131G>C	c.(4129-4131)AAG>AAC	p.K1377N	FER1L5_uc002sws.3_Missense_Mutation_p.K95N|FER1L5_uc010fib.1_RNA|FER1L5_uc002swt.3_Missense_Mutation_p.K95N|FER1L5_uc010yus.1_Missense_Mutation_p.K94N	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1377						integral to membrane				ovary(1)	1						TGCACCCAAAGCTTCCAAGTA	0.632		NA											6	29					0	0	0	0
ANKRD36	375248	broad.mit.edu	37	2	97869931	97869931	+	Missense_Mutation	SNP	A	A	T	rs76309140		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:97869931A>T	uc010yva.1	+	50	3236	c.2992A>T	c.(2992-2994)ACA>TCA	p.T998S	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	998											0						CATTCAGGCTACAAGTGATGA	0.289		NA											4	37					0	0	0	0
ZC3H8	84524	broad.mit.edu	37	2	112989456	112989456	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:112989456G>A	uc002thp.2	-	7	908	c.802C>T	c.(802-804)CAT>TAT	p.H268Y		NM_032494	NP_115883	Q8N5P1	ZC3H8_HUMAN	zinc finger CCCH-type containing 8	268	C3H1-type 3.				apoptosis|negative regulation of T cell differentiation in thymus|negative regulation of transcription, DNA-dependent|positive regulation of thymocyte apoptosis|response to antibiotic|T cell homeostasis	nucleus	RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGTGGAGCATGAGAAAACTTG	0.303		NA											20	81					0	0	0	0
POLR1B	84172	broad.mit.edu	37	2	113322029	113322029	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:113322029G>C	uc002thw.2	+	10	2279	c.1699G>C	c.(1699-1701)GAT>CAT	p.D567H	POLR1B_uc010fkn.2_Missense_Mutation_p.D511H|POLR1B_uc002thx.2_Missense_Mutation_p.D428H|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Missense_Mutation_p.D6H|POLR1B_uc010yxn.1_Missense_Mutation_p.D605H|POLR1B_uc002thy.2_Missense_Mutation_p.D428H|POLR1B_uc010yxo.1_Missense_Mutation_p.D344H	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	567					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						TGGCTGGGTGGATAAGGATCT	0.507		NA											42	212					0	0	0	0
KYNU	8942	broad.mit.edu	37	2	143790866	143790866	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:143790866C>G	uc002tvl.2	+	12	1147	c.1017C>G	c.(1015-1017)GTC>GTG	p.V339V	KYNU_uc010fnm.2_Silent_p.V339V	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	339					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTTGTTGGTCTGTTCCTTGC	0.378		NA											10	179					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	170115654	170115654	+	Silent	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:170115654G>T	uc002ues.2	-	17	2607	c.2394C>A	c.(2392-2394)CTC>CTA	p.L798L	LRP2_uc010zdf.1_Silent_p.L661L	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	798	LDL-receptor class B 7.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGTCCAATAGAGATTCTTTG	0.378		NA											38	66					2.05e-20	2.2e-20	1	0
HAT1	8520	broad.mit.edu	37	2	172822934	172822934	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:172822934G>C	uc002uhi.2	+	7	692	c.616G>C	c.(616-618)GAG>CAG	p.E206Q	HAT1_uc010fqi.2_Missense_Mutation_p.E41Q|HAT1_uc002uhj.2_Missense_Mutation_p.E121Q	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	206					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CTGCAGATTTGAGAAGTATAA	0.438		NA											3	40					0	0	0	0
EVX2	344191	broad.mit.edu	37	2	176948129	176948129	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:176948129G>A	uc010zeu.1	-	1	562	c.376C>T	c.(376-378)CGC>TGC	p.R126C		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	126						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CCGGGGGAGCGAAGCGCGGAG	0.682		NA											6	13					0	0	0	0
TTC30B	150737	broad.mit.edu	37	2	178415907	178415907	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:178415907C>G	uc002uln.2	-	1	1618	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	TTC30B_uc010zfc.1_Missense_Mutation_p.E301Q	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	529	Potential.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			GAGAGCTGCTCTTCCTCCTTT	0.378		NA											64	143					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179428814	179428814	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:179428814G>C	uc010zfg.1	-	275	74565	c.74341C>G	c.(74341-74343)CTG>GTG	p.L24781V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L18476V|TTN_uc010zfi.1_Missense_Mutation_p.L18409V|TTN_uc010zfj.1_Missense_Mutation_p.L18284V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25708							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAGTTTCAGAATATATTGT	0.413		NA											29	173					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179572396	179572396	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:179572396G>A	uc010zfg.1	-	97	25390	c.25166C>T	c.(25165-25167)TCA>TTA	p.S8389L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S5050L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9316							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATCTGTCTGAAGGCTTTAT	0.483		NA											18	36					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179611231	179611231	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:179611231G>A	uc002unb.2	-	46	16120	c.15896C>T	c.(15895-15897)ACC>ATC	p.T5299I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8817							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATGATGTGGTGTGTTCCAA	0.408		NA											13	34					0	0	0	0
CFLAR	8837	broad.mit.edu	37	2	202025553	202025553	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:202025553G>A	uc002uxb.3	+	9	1644	c.1192G>A	c.(1192-1194)GAA>AAA	p.E398K	CFLAR_uc010zhk.1_Missense_Mutation_p.E302K|CFLAR_uc002uxc.3_Missense_Mutation_p.E363K|CFLAR_uc010zhl.1_Missense_Mutation_p.E302K|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Missense_Mutation_p.E398K|CFLAR_uc002uxf.2_Missense_Mutation_p.E398K|CFLAR_uc010fsy.2_RNA|CFLAR_uc010fsx.2_Intron|CFLAR_uc010zhm.1_Missense_Mutation_p.E302K|CFLAR_uc010fsz.2_Missense_Mutation_p.E153K|CFLAR_uc002uxg.2_Missense_Mutation_p.E153K	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	398	Interaction with caspase-8.|Interaction with caspase-3.|Interaction with TRAF1 and TRAF2.|Not proteolytically processed and involved in apoptosis inhibition.|Interaction with caspase-8 subunits p18 and p10.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						AGTTCACCGAGAAGCTGACTT	0.577		NA											15	33					0	0	0	0
ALS2	57679	broad.mit.edu	37	2	202625889	202625889	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:202625889G>A	uc002uyo.2	-	4	1184	c.828C>T	c.(826-828)CTC>CTT	p.L276L	ALS2_uc002uyp.3_Silent_p.L276L|ALS2_uc002uyq.2_Silent_p.L276L|ALS2_uc002uyr.2_Silent_p.L276L	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	276					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TGGAGGGGCTGAGAGCAGTGC	0.453		NA											22	46					0	0	0	0
C2orf62	375307	broad.mit.edu	37	2	219222441	219222441	+	Silent	SNP	C	C	T	rs150544491		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:219222441C>T	uc002vhr.2	+	3	332	c.303C>T	c.(301-303)TGC>TGT	p.C101C	C2orf62_uc002vhs.2_RNA	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	101											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAATGCTCTGCGGAAATTCCC	0.527		NA											22	69					0	0	0	0
CHPF	79586	broad.mit.edu	37	2	220405145	220405145	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:220405145G>C	uc002vmc.3	-	4	1515	c.1288C>G	c.(1288-1290)CTA>GTA	p.L430V	CHPF_uc010zlh.1_Missense_Mutation_p.L268V	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	430	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGCTCCTCTAGAGCTGTCCCC	0.647		NA											20	18					0	0	0	0
PTMA	5757	broad.mit.edu	37	2	232576621	232576621	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr2:232576621G>T	uc002vsc.3	+	3	324	c.142G>T	c.(142-144)GAG>TAG	p.E48*	PTMA_uc002vsb.3_Nonsense_Mutation_p.E47*|PTMA_uc010zmf.1_RNA|MIR1244_hsa-mir-1244-1|MI0006379_5'Flank	NM_001099285	NP_001092755	P06454	PTMA_HUMAN	prothymosin, alpha isoform 1	48	Asp/Glu-rich (acidic).				transcription, DNA-dependent	nucleus					0		Renal(207;0.0112)|all_hematologic(139;0.0315)|Acute lymphoblastic leukemia(138;0.0921)|all_lung(227;0.142)		Epithelial(121;1.75e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00221)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		TGGGGAGCAGGAGGCTGACAA	0.418		NA											6	9					3.6e-05	3.71e-05	1	0
NSFL1C	55968	broad.mit.edu	37	20	1426360	1426360	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:1426360G>A	uc002wfc.2	-	8	1849	c.901C>T	c.(901-903)CGG>TGG	p.R301W	NSFL1C_uc002wfd.2_Missense_Mutation_p.R190W|NSFL1C_uc002wfe.2_Missense_Mutation_p.R270W|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Missense_Mutation_p.R67W	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	301	UBX.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						TCTGCAAGCCGAATTTGGATG	0.517		NA											26	258					0	0	0	0
ZNF343	79175	broad.mit.edu	37	20	2474452	2474452	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:2474452C>T	uc002wge.1	-	3	578	c.90G>A	c.(88-90)AAG>AAA	p.K30K	ZNF343_uc010gao.1_Silent_p.K30K|ZNF343_uc002wgd.1_5'Flank	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	30					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GGGTCAATTTCTTCATAGTCT	0.458		NA											35	154					0	0	0	0
ZNF343	79175	broad.mit.edu	37	20	2474463	2474463	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:2474463C>G	uc002wge.1	-	3	567	c.79G>C	c.(79-81)GAG>CAG	p.E27Q	ZNF343_uc010gao.1_Missense_Mutation_p.E27Q|ZNF343_uc002wgd.1_5'Flank	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E27K(1)		upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TTCATAGTCTCTACATTTTCC	0.473		NA											36	161					0	0	0	0
ATRN	8455	broad.mit.edu	37	20	3529964	3529964	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:3529964C>G	uc002wim.2	+	6	1181	c.1091C>G	c.(1090-1092)TCA>TGA	p.S364*	ATRN_uc002wil.2_Nonsense_Mutation_p.S364*	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	364	Extracellular (Potential).|Kelch 1.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TTCAACCACTCAGATTATAAC	0.299		NA											21	99					0	0	0	0
C20orf185	359710	broad.mit.edu	37	20	31647253	31647253	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:31647253G>A	uc002wym.1	+	3	351	c.351G>A	c.(349-351)CTG>CTA	p.L117L		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	117	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						GGGTGCAGCTGAGCCTGCACA	0.582		NA											13	24					0	0	0	0
TGM2	7052	broad.mit.edu	37	20	36789876	36789876	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:36789876C>T	uc002xhr.2	-	2	236	c.136G>A	c.(136-138)GAG>AAG	p.E46K	TGM2_uc010zvx.1_Missense_Mutation_p.E46K|TGM2_uc010zvy.1_Intron|TGM2_uc002xhs.1_Missense_Mutation_p.E46K|TGM2_uc002xht.2_Missense_Mutation_p.E46K|TGM2_uc002xhu.3_Missense_Mutation_p.E46K	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	46					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TTGCGGCCCTCAAAGTGCAGG	0.557		NA											9	72					0	0	0	0
ADA	100	broad.mit.edu	37	20	43251500	43251500	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:43251500G>A	uc002xmj.2	-	8	878	c.750C>T	c.(748-750)AAC>AAT	p.N250N	ADA_uc010ggt.2_RNA	NM_000022	NP_000013	P00813	ADA_HUMAN	adenosine deaminase	250					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			pancreas(2)|ovary(1)	3		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	GCCGCAGCCTGTTATAAAGGG	0.557		NA							Adenosine_Deaminase_Deficiency				27	133					0	0	0	0
NEURL2	140825	broad.mit.edu	37	20	44517447	44517447	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:44517447C>A	uc002xqg.1	-	2	1079	c.808G>T	c.(808-810)GAT>TAT	p.D270Y	C20orf165_uc002xqf.2_5'Flank|CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	270	SOCS box.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				TGGAGCCCATCAATGGCCAGC	0.542		NA											5	73					0.000602214	0.000617179	1	0
RBM38	55544	broad.mit.edu	37	20	55982766	55982766	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:55982766C>T	uc010zzj.1	+	4	759	c.584C>T	c.(583-585)TCG>TTG	p.S195L	RBM38_uc010zzk.1_3'UTR	NM_017495	NP_059965	Q9H0Z9	RBM38_HUMAN	RNA-binding region containing protein 1 isoform	195					3'-UTR-mediated mRNA stabilization|cell cycle|cell cycle arrest|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mRNA processing|negative regulation of cell proliferation|regulation of RNA splicing|RNA splicing	cytosol|cytosol|nucleus|nucleus	mRNA 3'-UTR binding|mRNA binding|nucleotide binding|RNA binding				0	Lung NSC(12;0.00242)|all_lung(29;0.00767)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.55e-12)|Epithelial(14;9.49e-09)|all cancers(14;5.01e-08)			TACGCCGCCTCGCCTGCCACG	0.692		NA											8	20					0	0	0	0
YTHDF1	54915	broad.mit.edu	37	20	61846954	61846954	+	Splice_Site	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:61846954C>G	uc002yeh.2	-	2	322	c.28_splice	c.e2-1	p.R10_splice		NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1											ovary(2)	2						CTTTTGTTCTCTGCACCGCCG	0.622		NA											17	29					0	0	0	0
KCNQ2	3785	broad.mit.edu	37	20	62038284	62038284	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:62038284C>A	uc002yey.1	-	17	2509	c.2332G>T	c.(2332-2334)GAG>TAG	p.E778*	KCNQ2_uc002yez.1_Nonsense_Mutation_p.E747*|KCNQ2_uc002yfa.1_Nonsense_Mutation_p.E760*|KCNQ2_uc002yfb.1_Nonsense_Mutation_p.E750*	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	778	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	AGGTTCCCCTCGGGGGGCCTG	0.701		NA											4	10					5.94e-07	6.19e-07	1	0
PRIC285	85441	broad.mit.edu	37	20	62203596	62203596	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr20:62203596G>C	uc002yfm.2	-	2	1035	c.143C>G	c.(142-144)ACC>AGC	p.T48S	PRIC285_uc002yfn.2_Missense_Mutation_p.T48S	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	48	C2H2-type; atypical.				cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			AGAGTGGCAGGTGACCAAGCA	0.706		NA											9	7					0	0	0	0
CXADR	1525	broad.mit.edu	37	21	18931416	18931416	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:18931416G>A	uc002yki.2	+	4	656	c.538G>A	c.(538-540)GAC>AAC	p.D180N	CXADR_uc002ykh.1_Missense_Mutation_p.D180N|CXADR_uc010gld.1_Intron|CXADR_uc010gle.1_Intron|CXADR_uc002ykj.1_Missense_Mutation_p.D153N	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	180	Extracellular (Potential).|Ig-like C2-type 2.				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		AAAATTGTCTGACTCACAGAA	0.383		NA											18	68					0	0	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812732	31812732	+	Missense_Mutation	SNP	C	C	G	rs138157793	byFrequency	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:31812732C>G	uc002yod.2	+	1	87	c.87C>G	c.(85-87)TTC>TTG	p.F29L		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	29						intermediate filament					0						ATAATTTGTTCTACCCCAGCA	0.478		NA											3	111					0	0	0	0
SON	6651	broad.mit.edu	37	21	34931614	34931614	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:34931614G>A	uc002yse.1	+	5	6449	c.6400G>A	c.(6400-6402)GAA>AAA	p.E2134K	SON_uc002ysc.2_Missense_Mutation_p.E2134K|SON_uc002ysd.2_Missense_Mutation_p.E1125K|SON_uc002ysf.1_Missense_Mutation_p.E162K|SON_uc002ysg.2_Missense_Mutation_p.E1125K	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2134					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TGAAGAGGAAGAAGAACCTCC	0.323		NA											11	143					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	41684117	41684117	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr21:41684117C>G	uc002yyq.1	-	9	2405	c.1953G>C	c.(1951-1953)ACG>ACC	p.T651T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	651	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCAAGGAGCTCGTGAAGTCAA	0.547		NA											20	78					0	0	0	0
UFD1L	7353	broad.mit.edu	37	22	19463117	19463117	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:19463117G>C	uc002zpm.2	-	2	142	c.12C>G	c.(10-12)TTC>TTG	p.F4L	UFD1L_uc002zpo.2_Missense_Mutation_p.F4L|UFD1L_uc011agy.1_Missense_Mutation_p.F4L|UFD1L_uc002zpp.2_5'UTR|UFD1L_uc010grq.2_5'UTR	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A	4					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					CGAACATGTTGAAAGAGAACT	0.423		NA											14	61					0	0	0	0
DGCR8	54487	broad.mit.edu	37	22	20079432	20079432	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:20079432C>G	uc002zri.2	+	7	1895	c.1545C>G	c.(1543-1545)ATC>ATG	p.I515M	DGCR8_uc010grz.2_Missense_Mutation_p.I515M|DGCR8_uc002zrj.2_Missense_Mutation_p.I158M	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	515	Necessary for interaction with DROSHA.|Necessary for heme-binding and pri-miRNA processing.|DRBM 1.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					AGGTCTGCATCCTGCACGAGT	0.468		NA											10	34					0	0	0	0
TRMT2A	27037	broad.mit.edu	37	22	20102116	20102116	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:20102116G>C	uc002zrk.1	-	8	1429	c.1214C>G	c.(1213-1215)TCT>TGT	p.S405C	TRMT2A_uc002zrl.1_Missense_Mutation_p.S405C|TRMT2A_uc002zrm.1_Missense_Mutation_p.S227C|TRMT2A_uc002zrn.1_Missense_Mutation_p.S405C|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	405					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						GGCGTGTGGAGAGATCCGGAA	0.632		NA											21	98					0	0	0	0
ZNF280B	140883	broad.mit.edu	37	22	22843165	22843165	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:22843165T>C	uc002zwc.1	-	4	1335	c.559A>G	c.(559-561)AGG>GGG	p.R187G	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGTTTAGCCCTTTTGGGATTT	0.388		NA											4	189					0	0	0	0
BCR	613	broad.mit.edu	37	22	23523385	23523385	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:23523385G>A	uc002zww.2	+	1	834	c.238G>A	c.(238-240)GCG>ACG	p.A80T	BCR_uc002zwx.2_Missense_Mutation_p.A80T	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	80	Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						CTTCCGGCGCGCGGCGCAGGC	0.736		NA	T	ABL1| FGFR1|JAK2 	CML|ALL|AML								3	4					0	0	0	0
ASPHD2	57168	broad.mit.edu	37	22	26829810	26829810	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:26829810C>G	uc003acg.2	+	2	626	c.229C>G	c.(229-231)CAC>GAC	p.H77D		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	77	Helical; (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						GTACTGTTATCACGTGGGCAG	0.637		NA											23	74					0	0	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30691787	30691787	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:30691787C>T	uc011akt.1	-	4	487	c.463G>A	c.(463-465)GAG>AAG	p.E155K	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Missense_Mutation_p.E13K|TBC1D10A_uc003ahj.3_Missense_Mutation_p.E67K|TBC1D10A_uc010gvu.2_Missense_Mutation_p.E162K|TBC1D10A_uc003ahk.3_Missense_Mutation_p.E155K	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	155	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						AGGTCACGCTCAATCACGTCC	0.617		NA											9	48					0	0	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119504	38119504	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38119504C>T	uc003atr.2	+	7	1212	c.941C>T	c.(940-942)TCC>TTC	p.S314F	TRIOBP_uc003atu.2_Missense_Mutation_p.S142F|TRIOBP_uc003atq.1_Missense_Mutation_p.S314F|TRIOBP_uc003ats.1_Missense_Mutation_p.S142F	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	314					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AGGGCCTCATCCACCCAAGAG	0.607		NA											62	159					0	0	0	0
H1F0	3005	broad.mit.edu	37	22	38202088	38202088	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38202088G>A	uc003aty.2	+	1	975	c.537G>A	c.(535-537)GTG>GTA	p.V179V	GCAT_uc003atz.2_5'Flank|GCAT_uc003aua.1_5'Flank	NM_005318	NP_005309	P07305	H10_HUMAN	H1 histone family, member 0	179					DNA fragmentation involved in apoptotic nuclear change|nucleosome assembly	actin cytoskeleton|Golgi apparatus|nucleoplasm|nucleosome	DNA binding				0	Melanoma(58;0.045)					CCAAACCAGTGAAACCCAAAG	0.502		NA											19	44					0	0	0	0
C22orf23	84645	broad.mit.edu	37	22	38349119	38349119	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38349119C>G	uc003auj.1	-	2	129	c.38G>C	c.(37-39)GGA>GCA	p.G13A	C22orf23_uc003auk.1_Missense_Mutation_p.G13A|POLR2F_uc010gxi.2_5'Flank|POLR2F_uc003aul.2_5'Flank|POLR2F_uc003aum.2_5'Flank	NM_032561	NP_115950	Q9BZE7	EVG1_HUMAN	hypothetical protein LOC84645	13											0	Melanoma(58;0.045)					GAACCCAGTTCCTTTGGTCAC	0.522		NA											39	143					0	0	0	0
DMC1	11144	broad.mit.edu	37	22	38945946	38945946	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:38945946C>G	uc003avz.1	-	8	653	c.478G>C	c.(478-480)GAT>CAT	p.D160H	DMC1_uc011anv.1_Intron|DMC1_uc003awa.1_Missense_Mutation_p.D160H	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	160					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					TTTTCTGTATCAATGAAGATA	0.328		NA						Homologous_recombination					8	40					0	0	0	0
SUN2	25777	broad.mit.edu	37	22	39138314	39138314	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:39138314G>A	uc003awh.1	-	10	1344	c.1060C>T	c.(1060-1062)CGC>TGC	p.R354C	SUN2_uc011anz.1_Missense_Mutation_p.R389C|SUN2_uc011aoa.1_Missense_Mutation_p.R343C|SUN2_uc003awi.1_Missense_Mutation_p.R354C|SUN2_uc010gxq.1_Missense_Mutation_p.R375C|SUN2_uc010gxr.1_Missense_Mutation_p.R354C|SUN2_uc010gxs.1_Missense_Mutation_p.R354C	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	354	Potential.|Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2						ACCTGGATGCGAGCAGCAGTT	0.607		NA											9	43					0	0	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41613186	41613186	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:41613186C>T	uc003azo.2	+	5	634	c.580C>T	c.(580-582)CCC>TCC	p.P194S	L3MBTL2_uc010gyi.1_Missense_Mutation_p.P103S|L3MBTL2_uc003azn.2_RNA|uc003azp.1_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	194	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						CAAGGCTGCTCCCGTCAGCTG	0.632		NA											25	54					0	0	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41613200	41613200	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:41613200C>T	uc003azo.2	+	5	648	c.594C>T	c.(592-594)TTC>TTT	p.F198F	L3MBTL2_uc010gyi.1_Silent_p.F107F|L3MBTL2_uc003azn.2_RNA|uc003azp.1_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	198	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						TCAGCTGTTTCAAGCACGTGA	0.627		NA											20	51					0	0	0	0
POLR3H	171568	broad.mit.edu	37	22	41925317	41925317	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr22:41925317C>T	uc003baf.2	-	7	645	c.585G>A	c.(583-585)CTG>CTA	p.L195L	POLR3H_uc003bae.2_RNA|POLR3H_uc003bag.2_Silent_p.L195L|POLR3H_uc003bai.2_Silent_p.L166L	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	195					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						AGAGAAGGCCCAGGCCTGGCT	0.597		NA											9	34					0	0	0	0
ITPR1	3708	broad.mit.edu	37	3	4699900	4699900	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:4699900C>G	uc003bqa.2	+	13	1437	c.1089C>G	c.(1087-1089)GAC>GAG	p.D363E	ITPR1_uc010hca.1_Missense_Mutation_p.D348E|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.D348E	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	363	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AAGGCAATGACATCTCCTCCA	0.507		NA											18	64					0	0	0	0
ITPR1	3708	broad.mit.edu	37	3	4725457	4725457	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:4725457G>C	uc003bqa.2	+	28	3794	c.3446G>C	c.(3445-3447)GGA>GCA	p.G1149A	ITPR1_uc010hca.1_Missense_Mutation_p.G1134A|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.G80A	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1158	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGTGCATCTGGAGAAAATGAA	0.473		NA											19	44					0	0	0	0
PRRT3	285368	broad.mit.edu	37	3	9990498	9990498	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:9990498G>C	uc003bul.2	-	3	1245	c.1115C>G	c.(1114-1116)TCA>TGA	p.S372*	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA|PRRT3_uc003bum.2_Nonsense_Mutation_p.S372*	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	372	Extracellular (Potential).|Pro-rich.					integral to membrane					0						GCCAGGGTCTGAGGGACCAGG	0.642		NA											63	168					0	0	0	0
VHL	7428	broad.mit.edu	37	3	10188211	10188211	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:10188211C>T	uc003bvc.2	+	2	567	c.354C>T	c.(352-354)CTC>CTT	p.L118L	VHL_uc003bvd.2_Intron	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	118	Involved in binding to CCT complex.		L -> R (in VHLD).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.L118P(4)|p.W117fs*40(1)|p.L118fs*14(1)|p.L118H(1)|p.?(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		ACCTTTGGCTCTTCAGAGATG	0.353		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				58	146					0	0	0	0
ATP2B2	491	broad.mit.edu	37	3	10392202	10392202	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:10392202G>A	uc003bvt.2	-	15	2635	c.2196C>T	c.(2194-2196)GGC>GGT	p.G732G	ATP2B2_uc003bvv.2_Silent_p.G687G|ATP2B2_uc003bvw.2_Silent_p.G687G|ATP2B2_uc010hdo.2_Silent_p.G437G	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	732	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TGATATTGTCGCCAGTGACCA	0.632		NA											26	72					0	0	0	0
IQSEC1	9922	broad.mit.edu	37	3	12983123	12983123	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:12983123G>C	uc003bxt.2	-	2	317	c.308C>G	c.(307-309)TCA>TGA	p.S103*	IQSEC1_uc003bxu.3_5'UTR|IQSEC1_uc011auw.1_Nonsense_Mutation_p.S89*	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	103					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						GAGTGAGCGTGAGCGCTTGAT	0.662		NA											5	22					0	0	0	0
C3orf20	84077	broad.mit.edu	37	3	14769987	14769987	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:14769987G>A	uc003byy.2	+	12	2136	c.1732G>A	c.(1732-1734)GAA>AAA	p.E578K	C3orf20_uc003byz.2_Missense_Mutation_p.E456K|C3orf20_uc003bza.2_Missense_Mutation_p.E456K|C3orf20_uc003bzb.1_Missense_Mutation_p.E79K	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	578	Poly-Glu.					cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GGAGGAGGAAGAATTTGTTCG	0.473		NA											23	94					0	0	0	0
COLQ	8292	broad.mit.edu	37	3	15512102	15512102	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:15512102C>T	uc003bzx.2	-	11	784	c.658G>A	c.(658-660)GAA>AAA	p.E220K	COLQ_uc003bzv.2_Missense_Mutation_p.E210K|COLQ_uc003bzz.2_Missense_Mutation_p.E211K|COLQ_uc010heo.2_Missense_Mutation_p.E186K|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Missense_Mutation_p.E79K|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	220	Collagen-like 1.				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						ATCCCAGGTTCACCTTTTGGA	0.537		NA											63	194					0	0	0	0
BTD	686	broad.mit.edu	37	3	15686312	15686312	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:15686312C>T	uc003cah.2	+	4	1052	c.949C>T	c.(949-951)CTG>TTG	p.L317L	BTD_uc011avv.1_Silent_p.L319L|BTD_uc011avw.1_Silent_p.L319L|BTD_uc011avx.1_Silent_p.L297L	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	317	CN hydrolase.				central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						ACACACCCCTCTGGAGTCCTT	0.488		NA											27	89					0	0	0	0
CRTAP	10491	broad.mit.edu	37	3	33155701	33155701	+	Silent	SNP	C	C	T	rs114946269	by1000genomes	TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:33155701C>T	uc003cfl.3	+	1	252	c.132C>T	c.(130-132)CTC>CTT	p.L44L	CRTAP_uc010hfz.2_Silent_p.L44L|CRTAP_uc003cfm.2_5'UTR|CRTAP_uc003cfn.2_5'UTR	NM_006371	NP_006362	O75718	CRTAP_HUMAN	cartilage associated protein precursor	44						proteinaceous extracellular matrix	binding				0						TGATGCCGCTCGAGTCGGCCT	0.697		NA											6	22					0	0	0	0
ARPP21	10777	broad.mit.edu	37	3	35778790	35778790	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:35778790C>A	uc003cgb.2	+	16	1844	c.1580C>A	c.(1579-1581)TCC>TAC	p.S527Y	ARPP21_uc003cga.2_Missense_Mutation_p.S473Y|ARPP21_uc011axy.1_Missense_Mutation_p.S493Y|ARPP21_uc003cgf.2_Missense_Mutation_p.S328Y|ARPP21_uc003cgg.2_Missense_Mutation_p.S15Y	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	527	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAGCAGCCCTCCCCGCAGCCC	0.642		NA											21	41					5.45e-15	5.83e-15	1	0
OXSR1	9943	broad.mit.edu	37	3	38266073	38266073	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:38266073G>A	uc003chy.2	+	8	1056	c.714G>A	c.(712-714)CTG>CTA	p.L238L	OXSR1_uc010hhb.2_Silent_p.L172L|OXSR1_uc010hha.1_Silent_p.L170L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	238	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTTTAATGCTGACACTGCAGA	0.289		NA											6	80					0	0	0	0
XIRP1	165904	broad.mit.edu	37	3	39226071	39226071	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:39226071C>G	uc003cjk.1	-	2	5087	c.4866G>C	c.(4864-4866)CAG>CAC	p.Q1622H	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.Q305H	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1622							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGACTTGACTCTGGGCCTCAG	0.562		NA											54	161					0	0	0	0
ZNF167	55888	broad.mit.edu	37	3	44612228	44612228	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:44612228G>C	uc010hin.2	+	6	2014	c.1626G>C	c.(1624-1626)CAG>CAC	p.Q542H	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.Q542H|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	542	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		TTGACCATCAGAGAATCCACA	0.463		NA											48	123					0	0	0	0
COL7A1	1294	broad.mit.edu	37	3	48625737	48625737	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:48625737G>A	uc003ctz.2	-	20	2689	c.2688C>T	c.(2686-2688)TTC>TTT	p.F896F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	896	Fibronectin type-III 8.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGTGCAGAAGGAAGCCCTGCG	0.682		NA											17	42					0	0	0	0
COL7A1	1294	broad.mit.edu	37	3	48626388	48626388	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:48626388G>A	uc003ctz.2	-	18	2356	c.2355C>T	c.(2353-2355)CTC>CTT	p.L785L		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	785	Nonhelical region (NC1).|Fibronectin type-III 7.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGAAGCATTGAGGATCTGCA	0.607		NA											30	92					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49692476	49692476	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:49692476C>G	uc003cxe.3	+	5	5601	c.5487C>G	c.(5485-5487)CTC>CTG	p.L1829L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1829					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCATTGGCCTCAAGCCAGGCC	0.612		NA											6	96					0	0	0	0
MST1R	4486	broad.mit.edu	37	3	49936568	49936568	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:49936568C>T	uc003cxy.3	-	2	1623	c.1359G>A	c.(1357-1359)GTG>GTA	p.V453V	MST1R_uc011bdd.1_Silent_p.V453V|MST1R_uc011bde.1_Silent_p.V453V|MST1R_uc011bdf.1_Intron|MST1R_uc011bdg.1_Silent_p.V453V|MST1R_uc011bdc.1_5'Flank	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	453	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CAAGGCGTGTCACATACAATG	0.577		NA											43	97					0	0	0	0
NT5DC2	64943	broad.mit.edu	37	3	52559068	52559068	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:52559068C>G	uc003deo.2	-	12	1571	c.1147G>C	c.(1147-1149)GAG>CAG	p.E383Q	NT5DC2_uc003dem.2_Missense_Mutation_p.E253Q|NT5DC2_uc003den.2_Missense_Mutation_p.E420Q|NT5DC2_uc010hmi.2_Missense_Mutation_p.E395Q|NT5DC2_uc010hmj.2_Missense_Mutation_p.E199Q	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	383							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		ATCTCACGCTCCAGCTCGGGG	0.682		NA											3	14					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	55717821	55717821	+	Splice_Site	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:55717821C>G	uc003dhr.1	-	17	3169	c.2913_splice	c.e17+1		ERC2_uc003dhq.1_Splice_Site	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110							cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGGTTTCTCACCCCTCAAAAC	0.478		NA											4	63					0	0	0	0
ATXN7	6314	broad.mit.edu	37	3	63973786	63973786	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:63973786G>C	uc003dlw.3	+	9	1700	c.1147G>C	c.(1147-1149)GAT>CAT	p.D383H	ATXN7_uc003dlv.2_Missense_Mutation_p.D383H|ATXN7_uc010hnv.2_Missense_Mutation_p.D383H|ATXN7_uc011bfn.1_Missense_Mutation_p.D238H	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	383	SCA7.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		AAAACGATTTGATGTGTTATT	0.458		NA											74	201					0	0	0	0
MITF	4286	broad.mit.edu	37	3	70014321	70014321	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:70014321C>T	uc003dnz.2	+	10	1601	c.1485C>T	c.(1483-1485)TCC>TCT	p.S495S	MITF_uc011bgb.1_Silent_p.S443S|MITF_uc003doa.2_Silent_p.S494S|MITF_uc003dob.2_Silent_p.S479S|MITF_uc003dod.2_Silent_p.S470S|MITF_uc003doe.2_Silent_p.S388S|MITF_uc003dof.2_Silent_p.S394S	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	501					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		CACTCCTTTCCTCAGTGTCCC	0.532		NA	A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						20	74					0	0	0	0
ROBO2	6092	broad.mit.edu	37	3	77666728	77666728	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:77666728G>C	uc003dpy.3	+	22	4001	c.3358G>C	c.(3358-3360)GAT>CAT	p.D1120H	ROBO2_uc003dpz.2_Missense_Mutation_p.D1124H|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.D1124H|ROBO2_uc003dqa.2_Missense_Mutation_p.D247H	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1120	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGGTCTGGAAGATGAACTGGA	0.458		NA											31	84					0	0	0	0
GABRR3	200959	broad.mit.edu	37	3	97711819	97711819	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:97711819G>C	uc011bgr.1	-	8	981	c.981C>G	c.(979-981)CTC>CTG	p.L327L		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	327	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0						CCACAGCCTTGAGGTAGGACA	0.532		NA											16	132					0	0	0	0
ST3GAL6	10402	broad.mit.edu	37	3	98512551	98512551	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:98512551C>G	uc003dsz.2	+	10	1178	c.942C>G	c.(940-942)CTC>CTG	p.L314L	ST3GAL6_uc003dsy.2_Silent_p.L228L|ST3GAL6_uc003dta.2_Silent_p.L196L|ST3GAL6_uc003dtb.2_Silent_p.L170L|ST3GAL6_uc003dtc.2_Silent_p.L314L|ST3GAL6_uc010hpd.2_Silent_p.L367L	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	314	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						CAGAGCAGCTCTTTTTGAAGG	0.353		NA											36	107					0	0	0	0
ZNF80	7634	broad.mit.edu	37	3	113955429	113955429	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:113955429C>G	uc010hqo.2	-	1	997	c.493G>C	c.(493-495)GAA>CAA	p.E165Q	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	165	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				TTTCCACATTCTTTGCACCCA	0.488		NA											17	156					0	0	0	0
PODXL2	50512	broad.mit.edu	37	3	127390296	127390296	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:127390296C>G	uc003ejq.2	+	7	1469	c.1445C>G	c.(1444-1446)TCC>TGC	p.S482C	ABTB1_uc003ejr.2_5'Flank|ABTB1_uc003ejs.2_5'Flank|ABTB1_uc003ejt.2_5'Flank|ABTB1_uc003eju.2_5'Flank	NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	482	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						CAGAACTATTCCACAACCAGC	0.632		NA											23	88					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130300643	130300643	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:130300643G>C	uc010htl.2	+	8	3817	c.3786G>C	c.(3784-3786)CTG>CTC	p.L1262L	COL6A6_uc003eni.3_5'Flank	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1262	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAAACATACTGAATAGCTTGA	0.413		NA											61	164					0	0	0	0
TF	7018	broad.mit.edu	37	3	133496034	133496034	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:133496034G>A	uc003epu.1	+	21	3742	c.2014G>A	c.(2014-2016)GAA>AAA	p.E672K	TF_uc011blt.1_Missense_Mutation_p.E545K|TF_uc003epw.1_Missense_Mutation_p.E111K|TF_uc003epv.1_Missense_Mutation_p.E672K	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	672	Transferrin-like 2.			E -> Q (in Ref. 12; AA sequence).	cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	ATACTTAGGAGAAGAATATGT	0.443		NA											13	40					0	0	0	0
NCK1	4690	broad.mit.edu	37	3	136664663	136664663	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:136664663C>A	uc003erh.2	+	3	572	c.465C>A	c.(463-465)TTC>TTA	p.F155L	NCK1_uc011bme.1_Missense_Mutation_p.F91L	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	155	SH3 2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						TTGGATGGTTCCCTTCAAACT	0.443		NA											19	169					1.16e-05	1.2e-05	1	0
C3orf58	205428	broad.mit.edu	37	3	143691432	143691432	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:143691432C>G	uc003evo.2	+	1	793	c.258C>G	c.(256-258)CTC>CTG	p.L86L	C3orf58_uc011bnl.1_5'Flank	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	86						COPI vesicle coat|extracellular region				ovary(1)	1						TGGACTTCCTCAACGTGAAGA	0.697		NA											7	48					0	0	0	0
PLOD2	5352	broad.mit.edu	37	3	145828128	145828128	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:145828128C>G	uc003evs.1	-	4	952	c.446G>C	c.(445-447)AGA>ACA	p.R149T	PLOD2_uc011bnm.1_Missense_Mutation_p.R94T|PLOD2_uc003evr.1_Missense_Mutation_p.R149T	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	149					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	GTCTGCTAGTCTTTTATCTGG	0.388		NA											25	76					0	0	0	0
IGSF10	285313	broad.mit.edu	37	3	151155923	151155923	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:151155923C>T	uc011bod.1	-	6	6426	c.6426G>A	c.(6424-6426)CGG>CGA	p.R2142R	IGSF10_uc011bob.1_Silent_p.R169R|IGSF10_uc011boc.1_Silent_p.R121R	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2142	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTGCCTTATCCGGGGAGCAG	0.458		NA											25	62					0	0	0	0
USP13	8975	broad.mit.edu	37	3	179481862	179481862	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:179481862C>G	uc003fkh.2	+	18	2246	c.2165C>G	c.(2164-2166)TCT>TGT	p.S722C		NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	722					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TTTGGTGCTTCTGGACTGGAT	0.502		NA											31	98					0	0	0	0
TP63	8626	broad.mit.edu	37	3	189582183	189582183	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:189582183G>A	uc003fry.2	+	5	831	c.742G>A	c.(742-744)GAG>AAG	p.E248K	TP63_uc003frx.2_Missense_Mutation_p.E248K|TP63_uc003frz.2_Missense_Mutation_p.E248K|TP63_uc010hzc.1_Missense_Mutation_p.E248K|TP63_uc003fsa.2_Missense_Mutation_p.E154K|TP63_uc003fsb.2_Missense_Mutation_p.E154K|TP63_uc003fsc.2_Missense_Mutation_p.E154K|TP63_uc003fsd.2_Missense_Mutation_p.E154K|TP63_uc010hzd.1_Missense_Mutation_p.E69K|TP63_uc003fse.1_Missense_Mutation_p.E129K	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	248					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCCCAACCATGAGCTGAGCCG	0.517		NA							Hay-Wells_syndrome	HNSCC(45;0.13)			25	64					0	0	0	0
TP63	8626	broad.mit.edu	37	3	189586432	189586432	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:189586432G>A	uc003fry.2	+	8	1145	c.1056G>A	c.(1054-1056)AGG>AGA	p.R352R	TP63_uc003frx.2_Silent_p.R352R|TP63_uc003frz.2_Silent_p.R352R|TP63_uc010hzc.1_Silent_p.R352R|TP63_uc003fsa.2_Silent_p.R258R|TP63_uc003fsb.2_Silent_p.R258R|TP63_uc003fsc.2_Silent_p.R258R|TP63_uc003fsd.2_Silent_p.R258R|TP63_uc010hzd.1_Silent_p.R173R|TP63_uc003fse.1_Silent_p.R233R	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	352	|Interaction with HIPK2.		R -> G (in EDRH and OFC8).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GAAGAGACAGGAAGGCGGATG	0.502		NA							Hay-Wells_syndrome	HNSCC(45;0.13)			17	66					0	0	0	0
PIGZ	80235	broad.mit.edu	37	3	196674441	196674441	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:196674441C>G	uc003fxh.2	-	3	1474	c.1327G>C	c.(1327-1329)GAG>CAG	p.E443Q		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	443					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		ACCACCTGCTCCAGGTACTCC	0.647		NA											4	46					0	0	0	0
BDH1	622	broad.mit.edu	37	3	197259341	197259341	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr3:197259341G>A	uc003fxr.2	-	5	611	c.209C>T	c.(208-210)TCA>TTA	p.S70L	BDH1_uc003fxs.2_Missense_Mutation_p.S70L|BDH1_uc003fxt.2_5'UTR|BDH1_uc003fxu.2_Missense_Mutation_p.S70L	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	70	NAD (By similarity).			S -> A (in Ref. 3; AAH11964).	cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	CTTGGCCAATGAGAACCCAAA	0.473		NA											10	42					0	0	0	0
MXD4	10608	broad.mit.edu	37	4	2259719	2259719	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:2259719C>G	uc003geu.1	-	3	216	c.184G>C	c.(184-186)GAA>CAA	p.E62Q	MXD4_uc003gev.1_RNA	NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	62	Basic motif.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						CTGTGCTTTTCTAGCTCGTTG	0.582		NA											13	47					0	0	0	0
LDB2	9079	broad.mit.edu	37	4	16590367	16590367	+	Missense_Mutation	SNP	C	C	A	rs142034467		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:16590367C>A	uc003goz.2	-	4	813	c.497G>T	c.(496-498)CGA>CTA	p.R166L	LDB2_uc003gpa.2_Missense_Mutation_p.R166L|LDB2_uc003gpb.2_Missense_Mutation_p.R166L|LDB2_uc011bxh.1_Missense_Mutation_p.R166L|LDB2_uc010iee.2_Missense_Mutation_p.R166L|LDB2_uc003goy.2_Missense_Mutation_p.R42L|LDB2_uc011bxi.1_Missense_Mutation_p.R42L	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	166							LIM domain binding|transcription cofactor activity				0						GACTAACTCTCGGTATTGTCT	0.393		NA											26	71					7.26e-15	7.76e-15	1	0
APBB2	323	broad.mit.edu	37	4	41016114	41016114	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:41016114G>A	uc003gvl.2	-	6	951	c.321C>T	c.(319-321)CTC>CTT	p.L107L	APBB2_uc003gvm.2_Silent_p.L107L|APBB2_uc003gvn.2_Silent_p.L107L|APBB2_uc011byt.1_Silent_p.L90L	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	107					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CAGCCTTACGGAGCTGGTTCT	0.562		NA											23	70					0	0	0	0
KCTD8	386617	broad.mit.edu	37	4	44176989	44176989	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:44176989G>C	uc003gwu.2	-	2	1524	c.1240C>G	c.(1240-1242)CAG>GAG	p.Q414E		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	414						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						ATGAGGGTCTGAAAGAGTTCA	0.428		NA								HNSCC(17;0.042)			77	247					0	0	0	0
LNX1	84708	broad.mit.edu	37	4	54364928	54364928	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:54364928G>C	uc003hag.3	-	5	1114	c.858C>G	c.(856-858)CTC>CTG	p.L286L	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Silent_p.L190L|LNX1_uc003hah.3_Intron	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	286	PDZ 1.					cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GCCTAATAGAGAGGCTTTCAC	0.483		NA											21	60					0	0	0	0
EPHA5	2044	broad.mit.edu	37	4	66217204	66217204	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:66217204C>T	uc003hcy.2	-	14	2604	c.2411G>A	c.(2410-2412)AGA>AAA	p.R804K	EPHA5_uc003hcx.2_Missense_Mutation_p.R736K|EPHA5_uc003hcz.2_Missense_Mutation_p.R782K|EPHA5_uc011cah.1_Missense_Mutation_p.R805K|EPHA5_uc011cai.1_Missense_Mutation_p.R783K|EPHA5_uc003hda.2_Missense_Mutation_p.R805K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	804	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TAAGATGTTTCTGGCAGCAAG	0.473		NA								TSP Lung(17;0.13)			18	65					0	0	0	0
UBA6	55236	broad.mit.edu	37	4	68514899	68514899	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:68514899G>A	uc003hdg.3	-	14	1187	c.1135C>T	c.(1135-1137)CTC>TTC	p.L379F	UBA6_uc003hdh.1_5'UTR	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	379					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						GTCCAAGAGAGCCAATGCACA	0.398		NA											12	49					0	0	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535910	69535910	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:69535910C>T	uc011cal.1	-	1	465	c.427G>A	c.(427-429)GAG>AAG	p.E143K		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	143					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						AACTTTGACTCTTGTAGTTTC	0.363		NA											95	271					0	0	0	0
UGT2A3	79799	broad.mit.edu	37	4	69816835	69816835	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:69816835G>A	uc003hef.2	-	1	675	c.644C>T	c.(643-645)TCA>TTA	p.S215L	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	215	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GAACAAAACTGAAAGCATTGA	0.358		NA											13	33					0	0	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73149386	73149386	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:73149386G>A	uc003hgk.1	-	22	3122	c.3085C>T	c.(3085-3087)CAA>TAA	p.Q1029*		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1029	PLAC.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACTTCCATTTGACAGAATATG	0.393		NA											25	63					0	0	0	0
PARM1	25849	broad.mit.edu	37	4	75938051	75938051	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:75938051C>G	uc003hih.1	+	2	700	c.460C>G	c.(460-462)CCA>GCA	p.P154A		NM_015393	NP_056208	Q6UWI2	PARM1_HUMAN	prostatic androgen-repressed message-1	154	Extracellular (Potential).				positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				ovary(1)	1						CCCTCAAGCTCCAGCCTCATC	0.587		NA											59	204					0	0	0	0
USO1	8615	broad.mit.edu	37	4	76703974	76703974	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:76703974C>G	uc003hiu.2	+	8	993	c.818C>G	c.(817-819)TCT>TGT	p.S273C	USO1_uc003hiv.2_Missense_Mutation_p.S108C|USO1_uc003hiw.2_Missense_Mutation_p.S108C	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	273	ARM 5.|Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTGGCTGGTCTGCACAGAAA	0.328		NA											5	30					0	0	0	0
SEC31A	22872	broad.mit.edu	37	4	83791497	83791497	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:83791497G>C	uc003hnf.2	-	8	1027	c.863C>G	c.(862-864)TCC>TGC	p.S288C	SEC31A_uc003hne.2_Missense_Mutation_p.S60C|SEC31A_uc011ccl.1_Missense_Mutation_p.S288C|SEC31A_uc003hnl.2_Missense_Mutation_p.S288C|SEC31A_uc003hng.2_Missense_Mutation_p.S288C|SEC31A_uc003hnh.2_Missense_Mutation_p.S288C|SEC31A_uc003hni.2_Missense_Mutation_p.S288C|SEC31A_uc003hnj.2_Missense_Mutation_p.S288C|SEC31A_uc011ccm.1_Missense_Mutation_p.S283C|SEC31A_uc011ccn.1_Missense_Mutation_p.S288C|SEC31A_uc003hnk.2_Missense_Mutation_p.S288C|SEC31A_uc003hnm.2_Missense_Mutation_p.S288C|SEC31A_uc003hnn.1_Missense_Mutation_p.S288C|SEC31A_uc003hno.2_Missense_Mutation_p.S288C	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	288	Interaction with SEC13.|WD 5.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GTTTGGATTGGAGCAGAGAAT	0.408		NA											38	134					0	0	0	0
MANBA	4126	broad.mit.edu	37	4	103585971	103585971	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:103585971C>T	uc003hwg.2	-	11	1456	c.1356G>A	c.(1354-1356)TGG>TGA	p.W452*	MANBA_uc011ces.1_Nonsense_Mutation_p.W395*	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	452					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		TATTGCCACTCCATATGATGA	0.343		NA											24	73					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111470954	111470954	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:111470954G>C	uc003iab.3	+	17	2755	c.2413G>C	c.(2413-2415)GAG>CAG	p.E805Q		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	805	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CTACACTCTTGAGCAATACCA	0.413		NA											22	61					0	0	0	0
C4orf21	55345	broad.mit.edu	37	4	113468485	113468485	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:113468485C>T	uc003iau.2	-	24	5765	c.5554G>A	c.(5554-5556)GAA>AAA	p.E1852K	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.E310K	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	674						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AATCCATTTTCATGAGCTGCA	0.363		NA											10	57					0	0	0	0
SEC24D	9871	broad.mit.edu	37	4	119736304	119736304	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:119736304G>C	uc003ici.3	-	6	952	c.680C>G	c.(679-681)TCT>TGT	p.S227C	SEC24D_uc003icj.3_Missense_Mutation_p.S228C|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	227	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						CTGGGGACCAGAGTTGGCTGC	0.498		NA											20	64					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126241934	126241934	+	Silent	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:126241934C>A	uc003ifj.3	+	1	4368	c.4368C>A	c.(4366-4368)TCC>TCA	p.S1456S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1456	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTCAACTATCCTACACAATCA	0.388		NA											27	101					4.23e-11	4.48e-11	1	0
TUBB4Q	56604	broad.mit.edu	37	4	190903695	190903695	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:190903695C>T	uc011clg.1	-	4	1288	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	430					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		CCTCCTCCCTCGGCCGTGGCA	0.532		NA											84	209					0	0	0	0
PDZD2	23037	broad.mit.edu	37	5	32091009	32091009	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:32091009G>C	uc003jhl.2	+	20	7843	c.7455G>C	c.(7453-7455)CTG>CTC	p.L2485L	PDZD2_uc003jhm.2_Silent_p.L2485L	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2485					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TCCAGGAGCTGAGAGCCTTGA	0.607		NA											30	59					0	0	0	0
SKP2	6502	broad.mit.edu	37	5	36181975	36181975	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:36181975G>C	uc003jkc.1	+	10	1299	c.1117G>C	c.(1117-1119)GAT>CAT	p.D373H	SKP2_uc011cou.1_Missense_Mutation_p.D159H|SKP2_uc003jkd.2_Intron	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	373					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATCGTGCCAGATGGTACCCT	0.403		NA											65	159					0	0	0	0
WDR70	55100	broad.mit.edu	37	5	37479940	37479940	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:37479940C>T	uc003jkv.2	+	8	749	c.691C>T	c.(691-693)CAG>TAG	p.Q231*	WDR70_uc010iva.1_Nonsense_Mutation_p.Q231*	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	231	WD 2.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTACAGCCATCAGATCAAGTC	0.338		NA											30	107					0	0	0	0
C5orf51	285636	broad.mit.edu	37	5	41911231	41911231	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:41911231C>G	uc003jmo.2	+	4	436	c.436C>G	c.(436-438)CTT>GTT	p.L146V		NM_175921	NP_787117	A6NDU8	CE051_HUMAN	hypothetical protein LOC285636	146											0						TTGTCATTCTCTTACCAAAAG	0.388		NA											16	44					0	0	0	0
PAIP1	10605	broad.mit.edu	37	5	43535702	43535702	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:43535702C>T	uc003job.2	-	7	1260	c.1013G>A	c.(1012-1014)GGA>GAA	p.G338E	PAIP1_uc003joa.2_Missense_Mutation_p.G259E|PAIP1_uc010ivp.2_Missense_Mutation_p.G259E|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.G226E	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	338	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATCCATCTTTCCTTTTTCCTT	0.328		NA											15	46					0	0	0	0
NNT	23530	broad.mit.edu	37	5	43616149	43616149	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:43616149C>T	uc003joe.2	+	4	836	c.581C>T	c.(580-582)TCC>TTC	p.S194F	NNT_uc003jof.2_Missense_Mutation_p.S194F	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	194	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GCGCTAAGCTCCATGGCCAAC	0.433		NA											64	133					0	0	0	0
PARP8	79668	broad.mit.edu	37	5	50091070	50091070	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:50091070G>C	uc003jon.3	+	13	1429	c.1247G>C	c.(1246-1248)AGA>ACA	p.R416T	PARP8_uc011cpz.1_Missense_Mutation_p.R308T|PARP8_uc003joo.2_Missense_Mutation_p.R416T|PARP8_uc003jop.2_Missense_Mutation_p.R416T	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	416						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				AGTAATCTCAGAATGGAAGAA	0.418		NA											12	76					0	0	0	0
MAST4	375449	broad.mit.edu	37	5	66456300	66456300	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:66456300C>G	uc003jut.1	+	26	3166	c.3098C>G	c.(3097-3099)TCA>TGA	p.S1033*	MAST4_uc003juw.2_Nonsense_Mutation_p.S961*	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1225	PDZ.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AATAAGGTGTCAATCACTACT	0.423		NA											64	186					0	0	0	0
GCNT4	51301	broad.mit.edu	37	5	74324700	74324700	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:74324700C>T	uc003kdn.2	-	1	2025	c.1163G>A	c.(1162-1164)CGA>CAA	p.R388Q		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	388	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		ACACACGCTTCGAAGGTGAGA	0.418		NA											24	64					0	0	0	0
HMGCR	3156	broad.mit.edu	37	5	74646146	74646146	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:74646146G>A	uc003kdp.2	+	8	883	c.727G>A	c.(727-729)GAA>AAA	p.E243K	HMGCR_uc011cst.1_Missense_Mutation_p.E263K|HMGCR_uc003kdq.2_Missense_Mutation_p.E243K|HMGCR_uc010izn.1_Intron	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	243					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CCGAGTTTTAGAAGAAGAAGA	0.413		NA											5	65					0	0	0	0
S100Z	170591	broad.mit.edu	37	5	76171314	76171314	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:76171314G>A	uc003kep.1	+	3	460	c.130G>A	c.(130-132)GAA>AAA	p.E44K	S100Z_uc003keq.3_Missense_Mutation_p.E44K	NM_130772	NP_570128	Q8WXG8	S100Z_HUMAN	S100 calcium binding protein Z	44	EF-hand 1.						calcium ion binding			ovary(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;8.91e-51)|Epithelial(54;5.43e-45)|all cancers(79;1.82e-40)		AGAGCTCACGGAATTCCTCTC	0.493		NA											32	111					0	0	0	0
ATP6AP1L	92270	broad.mit.edu	37	5	81613993	81613993	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:81613993C>T	uc003khv.2	+	10	1874	c.549C>T	c.(547-549)ATC>ATT	p.I183I	ATP6AP1L_uc003khw.2_Silent_p.I183I	NM_001017971	NP_001017971	Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory	183					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						ATGATCTCATCGCCTCTCCTG	0.557		NA											17	70					0	0	0	0
CETN3	1070	broad.mit.edu	37	5	89705476	89705476	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:89705476C>T	uc003kjo.2	-	1	128	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_004365	NP_004356	O15182	CETN3_HUMAN	centrin 3	1					cell division|centrosome cycle|mitosis	centriole	calcium ion binding				0		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		GAGCTAAACTCATTATCTCTT	0.582		NA											38	114					0	0	0	0
NR2F1	7025	broad.mit.edu	37	5	92929548	92929548	+	Nonstop_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:92929548G>C	uc003kkj.2	+	3	2959	c.1272G>C	c.(1270-1272)TAG>TAC	p.*424Y		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	424					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		AGTGCTCCTAGACCTTGGGCG	0.597		NA											8	85					0	0	0	0
FBN2	2201	broad.mit.edu	37	5	127654636	127654636	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:127654636G>C	uc003kuu.2	-	35	4968	c.4529C>G	c.(4528-4530)CCT>CGT	p.P1510R		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1510	EGF-like 25; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AAACATTCCAGGCAGGTTATT	0.358		NA											5	113					0	0	0	0
SLC27A6	28965	broad.mit.edu	37	5	128364098	128364098	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:128364098C>T	uc003kuy.2	+	9	1911	c.1515C>T	c.(1513-1515)TTC>TTT	p.F505F	SLC27A6_uc003kuz.2_Silent_p.F505F	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	505					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TGTTGGATTTCATACAGGAAG	0.343		NA											18	68					0	0	0	0
SPOCK1	6695	broad.mit.edu	37	5	136403477	136403477	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:136403477G>A	uc003lbo.2	-	5	707	c.516C>T	c.(514-516)CTC>CTT	p.L172L	SPOCK1_uc003lbp.2_Silent_p.L172L	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	172	Kazal-like.				cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGAGGGTGGCGAGGCTTTTGC	0.527		NA											48	159					0	0	0	0
KLHL3	26249	broad.mit.edu	37	5	136964011	136964011	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:136964011G>A	uc010jek.2	-	13	2010	c.1566C>T	c.(1564-1566)GAC>GAT	p.D522D	KLHL3_uc011cyc.1_Silent_p.D257D|KLHL3_uc003lbr.3_Silent_p.D440D|KLHL3_uc011cyd.1_RNA	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	522	Kelch 5.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		ACATGTTCATGTCTGCCACTT	0.547		NA											29	195					0	0	0	0
KLHL3	26249	broad.mit.edu	37	5	137028128	137028128	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:137028128G>A	uc010jek.2	-	5	816	c.372C>T	c.(370-372)CTC>CTT	p.L124L	KLHL3_uc003lbr.3_Silent_p.L42L|KLHL3_uc011cyd.1_RNA|MYOT_uc011cye.1_Intron|KLHL3_uc010jem.1_Silent_p.L84L|KLHL3_uc010jen.1_RNA|KLHL3_uc003lbs.1_5'UTR	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	124						cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		TGGCTGCCGGGAGCAGCACCT	0.527		NA											8	43					0	0	0	0
BRD8	10902	broad.mit.edu	37	5	137497522	137497522	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:137497522C>T	uc003lcf.1	-	17	2267	c.2212G>A	c.(2212-2214)GAT>AAT	p.D738N	BRD8_uc003lcc.1_RNA|BRD8_uc011cyl.1_Missense_Mutation_p.D517N|BRD8_uc003lcg.2_Missense_Mutation_p.D811N|BRD8_uc003lci.2_Missense_Mutation_p.D741N|BRD8_uc003lch.2_Missense_Mutation_p.D632N|BRD8_uc011cym.1_Missense_Mutation_p.D722N|BRD8_uc010jer.1_Missense_Mutation_p.D707N|BRD8_uc011cyn.1_Missense_Mutation_p.D697N	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	738	Bromo 1.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCTATGTCATCTGTAACAGGC	0.463		NA											16	65					0	0	0	0
KDM3B	51780	broad.mit.edu	37	5	137754821	137754821	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:137754821G>A	uc003lcy.1	+	14	3815	c.3615G>A	c.(3613-3615)CTG>CTA	p.L1205L	KDM3B_uc010jew.1_Silent_p.L861L|KDM3B_uc011cys.1_Silent_p.L237L	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1205					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						ATAGTGAACTGAAAGCCATCA	0.522		NA											20	50					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236754	140236754	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140236754C>G	uc003lhx.2	+	1	1121	c.1121C>G	c.(1120-1122)TCT>TGT	p.S374C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.S374C|PCDHA10_uc011dad.1_Missense_Mutation_p.S374C	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	374	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCAGCGTTTCTGACCATGAT	0.488		NA											33	133					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236766	140236766	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140236766C>T	uc003lhx.2	+	1	1133	c.1133C>T	c.(1132-1134)TCA>TTA	p.S378L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.S378L|PCDHA10_uc011dad.1_Missense_Mutation_p.S378L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	378	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCATGATTCAGGAGCCAAC	0.512		NA											32	136					0	0	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764372	140764372	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140764372G>C	uc003lka.1	+	1	1906	c.1906G>C	c.(1906-1908)GAT>CAT	p.D636H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D636H	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	636	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGACAGAGATGCCCTCAA	0.652		NA											16	46					0	0	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774356	140774356	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140774356C>T	uc003lkd.1	+	1	2874	c.1976C>T	c.(1975-1977)ACG>ATG	p.T659M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.T659M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	659	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACTGTCACGCTCACCGTA	0.642		NA											10	36					0	0	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140793078	140793078	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:140793078C>G	uc003lkl.1	+	1	336	c.336C>G	c.(334-336)ATC>ATG	p.I112M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.I112M	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	112	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTAATATCCTTGTGGAAG	0.488		NA											42	99					0	0	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142283207	142283207	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:142283207G>T	uc011dbj.1	+	8	840	c.805G>T	c.(805-807)GAG>TAG	p.E269*	ARHGAP26_uc003lmt.2_Nonsense_Mutation_p.E269*|ARHGAP26_uc003lmw.2_Nonsense_Mutation_p.E269*	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	269	PH.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTACACCATGGAGGGATACCT	0.473		NA											22	73					2.89e-11	3.06e-11	1	0
SLC36A2	153201	broad.mit.edu	37	5	150723127	150723127	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:150723127G>A	uc003lty.2	-	3	418	c.288C>T	c.(286-288)TTC>TTT	p.F96F	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_5'UTR|SLC36A2_uc010jhv.2_Silent_p.F96F|SLC36A2_uc011dct.1_Silent_p.F96F	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	96	Helical; (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCAGGCAATGAAGCCCATCA	0.527		NA											31	109					0	0	0	0
G3BP1	10146	broad.mit.edu	37	5	151169928	151169928	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:151169928C>G	uc003lun.2	+	3	311	c.140C>G	c.(139-141)TCA>TGA	p.S47*	G3BP1_uc010jhy.1_Nonsense_Mutation_p.S47*|G3BP1_uc003lum.2_Nonsense_Mutation_p.S47*|G3BP1_uc011dcu.1_5'UTR|G3BP1_uc010jhz.2_5'UTR	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	47	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GGATTGGATTCAAATGGAAAG	0.343		NA											6	30					0	0	0	0
SLIT3	6586	broad.mit.edu	37	5	168127613	168127613	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:168127613C>G	uc003mab.2	-	27	3336	c.2916G>C	c.(2914-2916)CTG>CTC	p.L972L	SLIT3_uc010jjg.2_Silent_p.L979L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	972	EGF-like 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGCTGTCACTCAGGTGGCAGG	0.453		NA											27	71					0	0	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026363	176026363	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:176026363G>C	uc003meo.1	-	2	648	c.473C>G	c.(472-474)TCA>TGA	p.S158*		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	158						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCTGCTTTGAGGACTTGAA	0.502		NA											42	108					0	0	0	0
ZFP2	80108	broad.mit.edu	37	5	178358745	178358745	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:178358745C>T	uc003mjn.1	+	5	940	c.431C>T	c.(430-432)TCC>TTC	p.S144F	ZFP2_uc010jky.2_Missense_Mutation_p.S144F|ZFP2_uc010jkx.1_Missense_Mutation_p.S144F	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	144	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GAACGATCCTCCCTTACTGTA	0.403		NA											19	58					0	0	0	0
ZFP2	80108	broad.mit.edu	37	5	178359095	178359095	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr5:178359095C>T	uc003mjn.1	+	5	1290	c.781C>T	c.(781-783)CAG>TAG	p.Q261*	ZFP2_uc010jky.2_Nonsense_Mutation_p.Q261*|ZFP2_uc010jkx.1_Nonsense_Mutation_p.Q261*	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	261	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TATTGTACATCAGAGAAGCCA	0.398		NA											23	76					0	0	0	0
HLA-A	3105	broad.mit.edu	37	6	29910683	29910683	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:29910683T>C	uc003nol.2	+	2	223	c.223T>C	c.(223-225)TGG>CGG	p.W75R	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Missense_Mutation_p.W75R|HLA-A_uc003noo.2_Missense_Mutation_p.W75R|HLA-A_uc010jrr.2_Missense_Mutation_p.W75R|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Missense_Mutation_p.W47R|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	75	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCGGGCGCCGTGGATAGAGCA	0.677		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			11	16					0	0	0	0
EGFL8	80864	broad.mit.edu	37	6	32135415	32135415	+	Missense_Mutation	SNP	G	G	C	rs17853434		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:32135415G>C	uc003oab.1	+	8	875	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.E273Q	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	273				E -> Q (in Ref. 6; AAH35574).		extracellular region|integral to membrane	calcium ion binding				0						GCTGCTGCTGGAGGAGAGGCT	0.612		NA											23	28					0	0	0	0
BRD2	6046	broad.mit.edu	37	6	32942323	32942323	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:32942323C>T	uc003ocn.3	+	3	1815	c.114C>T	c.(112-114)CTC>CTT	p.L38L	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.L38L|BRD2_uc003ocp.3_5'UTR|BRD2_uc010juh.2_Silent_p.L38L	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	38					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AACCCTCTCTCTTGTATGAGG	0.582		NA											10	80					0	0	0	0
ANKS1A	23294	broad.mit.edu	37	6	35027938	35027938	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:35027938G>A	uc003ojx.3	+	13	2234	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Missense_Mutation_p.E238K|ANKS1A_uc010jvp.1_Missense_Mutation_p.E72K	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	698	SAM 1.					cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACGGACGCTGGAGCAGAGTGT	0.527		NA											6	17					0	0	0	0
DEF6	50619	broad.mit.edu	37	6	35280429	35280429	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:35280429G>A	uc003okk.2	+	5	726	c.687G>A	c.(685-687)CTG>CTA	p.L229L	DEF6_uc010jvs.2_Silent_p.L229L|DEF6_uc010jvt.2_Intron	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	229	PH.					cytoplasm|nucleus|plasma membrane					0						GAGGGCACCTGAGAAGGAACT	0.612		NA											3	29					0	0	0	0
SRPK1	6732	broad.mit.edu	37	6	35888247	35888247	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:35888247C>T	uc003olj.2	-	2	195	c.72G>A	c.(70-72)AGG>AGA	p.R24R	SRPK1_uc003olh.2_5'UTR|SRPK1_uc003oli.2_5'UTR	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	24					cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						AGACTCACTTCCTTTGGGCTT	0.542		NA											59	102					0	0	0	0
STK38	11329	broad.mit.edu	37	6	36475338	36475338	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:36475338C>T	uc003omg.2	-	7	1299	c.711G>A	c.(709-711)CTG>CTA	p.L237L	STK38_uc003omh.2_Silent_p.L237L|STK38_uc003omi.2_Silent_p.L237L	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	237	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						GTGCTTTTTTCAGTCCTGTGC	0.408		NA											92	176					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38791364	38791364	+	Silent	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:38791364G>C	uc003ooe.1	+	26	3696	c.3096G>C	c.(3094-3096)CTG>CTC	p.L1032L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACCCCTCTCTGACTGAAATCA	0.318		NA											11	61					0	0	0	0
FOXP4	116113	broad.mit.edu	37	6	41552527	41552527	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:41552527G>A	uc003oql.2	+	4	779	c.321G>A	c.(319-321)ATG>ATA	p.M107I	FOXP4_uc003oqm.2_Missense_Mutation_p.M107I|FOXP4_uc003oqn.2_Missense_Mutation_p.M107I	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	107	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					CGGTGGCCATGATGTCGCCGC	0.662		NA											3	6					0	0	0	0
TRERF1	55809	broad.mit.edu	37	6	42227372	42227372	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:42227372C>T	uc003osd.2	-	9	2537	c.1974G>A	c.(1972-1974)CCG>CCA	p.P658P	TRERF1_uc011duq.1_Silent_p.P575P|TRERF1_uc003osb.2_Silent_p.P414P|TRERF1_uc003osc.2_Silent_p.P414P|TRERF1_uc003ose.2_Silent_p.P678P	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	658	Pro-rich.|Interacts with CREBBP.			P -> S (in Ref. 2; CAB88206/CAB88207).	cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGAGAGGTTCCGGCCGGTGCC	0.652		NA											21	66					0	0	0	0
YIPF3	25844	broad.mit.edu	37	6	43480834	43480834	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:43480834G>A	uc003ovl.1	-	6	796	c.639C>T	c.(637-639)ATC>ATT	p.I213I	C6orf154_uc003ovk.1_5'Flank|YIPF3_uc011dvk.1_Silent_p.I178I|YIPF3_uc010jyr.1_Silent_p.I219I|YIPF3_uc010jys.1_Silent_p.I56I|YIPF3_uc003ovm.1_Silent_p.I87I|YIPF3_uc010jyt.1_Silent_p.I162I	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	natural killer cell-specific antigen KLIP1	213					cell differentiation	integral to membrane|plasma membrane|transport vesicle					0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCAGCATGGTGATCTGGGCGT	0.562		NA											52	154					0	0	0	0
RUNX2	860	broad.mit.edu	37	6	45514677	45514677	+	Missense_Mutation	SNP	A	A	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:45514677A>C	uc011dvx.1	+	9	1411	c.1201A>C	c.(1201-1203)ACC>CCC	p.T401P	RUNX2_uc011dvy.1_Missense_Mutation_p.T379P|RUNX2_uc003oxt.2_Missense_Mutation_p.T387P	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	401	Interaction with MYST3 (By similarity).|Pro/Ser/Thr-rich.|Interaction with MYST4.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CTTTACTTACACCCCGCCAGT	0.587		NA											7	63					0	0	0	0
GPR116	221395	broad.mit.edu	37	6	46851916	46851916	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46851916C>G	uc003oyo.3	-	5	710	c.421G>C	c.(421-423)GAG>CAG	p.E141Q	GPR116_uc003oyp.3_Missense_Mutation_p.E141Q|GPR116_uc003oyq.3_Missense_Mutation_p.E141Q|GPR116_uc003oyr.2_Missense_Mutation_p.E141Q	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	141	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			ACGTCACGCTCTTGACAAATG	0.502		NA											17	125					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977116	46977116	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977116C>T	uc003oyt.2	-	11	2254	c.2055G>A	c.(2053-2055)CGG>CGA	p.R685R	GPR110_uc011dwl.1_Silent_p.R373R	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	685	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CGAGGATGATCCGGTAAGCCA	0.483		NA											15	47					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977149	46977149	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977149C>T	uc003oyt.2	-	11	2221	c.2022G>A	c.(2020-2022)TGG>TGA	p.W674*	GPR110_uc011dwl.1_Nonsense_Mutation_p.W362*	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	674	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						GCATGAGCATCCAGAAGAACA	0.498		NA											11	48					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977208	46977208	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977208C>T	uc003oyt.2	-	11	2162	c.1963G>A	c.(1963-1965)GGA>AGA	p.G655R	GPR110_uc011dwl.1_Missense_Mutation_p.G343R	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	655	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						GTGCAGACTCCAGAAGGGTTC	0.498		NA											7	33					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977266	46977266	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977266C>G	uc003oyt.2	-	11	2104	c.1905G>C	c.(1903-1905)TTG>TTC	p.L635F	GPR110_uc011dwl.1_Missense_Mutation_p.L323F	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	635	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CATCAGCAATCAAGAGGGACA	0.468		NA											8	40					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977332	46977332	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977332C>A	uc003oyt.2	-	11	2038	c.1839G>T	c.(1837-1839)CAG>CAT	p.Q613H	GPR110_uc011dwl.1_Missense_Mutation_p.Q301H	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	613	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TTTTTTTAATCTGCTTCCAAA	0.443		NA											10	50					3.86e-05	3.98e-05	1	0
GPR110	266977	broad.mit.edu	37	6	46977338	46977338	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977338C>T	uc003oyt.2	-	11	2032	c.1833G>A	c.(1831-1833)TGG>TGA	p.W611*	GPR110_uc011dwl.1_Nonsense_Mutation_p.W299*	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	611	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TAATCTGCTTCCAAAACAAAG	0.438		NA											12	53					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977410	46977410	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977410C>A	uc003oyt.2	-	11	1960	c.1761G>T	c.(1759-1761)TGG>TGT	p.W587C	GPR110_uc011dwl.1_Missense_Mutation_p.W275C	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	587	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CATAGGTGATCCATTTTACAA	0.433		NA											18	91					5.26e-13	5.61e-13	1	0
GPR110	266977	broad.mit.edu	37	6	46977535	46977535	+	Missense_Mutation	SNP	C	C	T	rs112946460		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977535C>T	uc003oyt.2	-	11	1835	c.1636G>A	c.(1636-1638)GAT>AAT	p.D546N	GPR110_uc011dwl.1_Missense_Mutation_p.D234N	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	546	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CAgcctgcatcgttccactgc	0.264		NA											13	43					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977656	46977656	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977656C>G	uc003oyt.2	-	11	1714	c.1515G>C	c.(1513-1515)GTG>GTC	p.V505V	GPR110_uc011dwl.1_Silent_p.V193V	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	505	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CCGTGGATATCACAGGTCCAT	0.313		NA											20	82					0	0	0	0
GPR110	266977	broad.mit.edu	37	6	46977742	46977742	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:46977742C>T	uc003oyt.2	-	11	1628	c.1429G>A	c.(1429-1431)GAA>AAA	p.E477K	GPR110_uc011dwl.1_Missense_Mutation_p.E165K	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	477	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						ATAATAGTTTCTGGAAGGGAT	0.443		NA											22	77					0	0	0	0
CRISP3	10321	broad.mit.edu	37	6	49698947	49698947	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:49698947C>T	uc003ozs.2	-	7	554	c.539G>A	c.(538-540)AGA>AAA	p.R180K		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	180					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GACATATAGTCTATTAGCCCA	0.333		NA											17	54					0	0	0	0
SENP6	26054	broad.mit.edu	37	6	76407199	76407199	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:76407199G>C	uc003pid.3	+	18	2873	c.2254G>C	c.(2254-2256)GAG>CAG	p.E752Q	SENP6_uc003pie.3_Missense_Mutation_p.E745Q|SENP6_uc010kbf.2_RNA	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	752	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				AGATATTTTTGAGAAGGATTT	0.303		NA											10	25					0	0	0	0
TCF21	6943	broad.mit.edu	37	6	134212923	134212923	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:134212923G>A	uc003qei.3	+	2	799	c.523G>A	c.(523-525)GGA>AGA	p.G175R	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.G175R	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	175					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CCGCTTATGTGGAACCACCGC	0.657		NA											11	34					0	0	0	0
HECA	51696	broad.mit.edu	37	6	139487747	139487747	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr6:139487747G>A	uc003qin.2	+	2	883	c.598G>A	c.(598-600)GAG>AAG	p.E200K		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	200					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		GATGCAGGACGAGAAAAAGAA	0.582		NA											37	45					0	0	0	0
MICALL2	79778	broad.mit.edu	37	7	1479682	1479682	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:1479682C>T	uc003skj.3	-	9	1992	c.1845G>A	c.(1843-1845)CCG>CCA	p.P615P	MICALL2_uc003skh.3_5'Flank|MICALL2_uc003ski.3_Silent_p.P102P	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	615						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CCCCCGCCCTCGGCTCTGCCA	0.687		NA											28	61					0	0	0	0
KIAA0415	9907	broad.mit.edu	37	7	4830913	4830913	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:4830913T>A	uc003sne.2	+	17	2404	c.2321T>A	c.(2320-2322)GTG>GAG	p.V774E	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Missense_Mutation_p.V251E	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	774					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		AGCACGGAGGTGTGCAGCCCC	0.697		NA											8	21					0	0	0	0
GLCCI1	113263	broad.mit.edu	37	7	8062158	8062158	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:8062158C>A	uc003srk.2	+	3	1214	c.655C>A	c.(655-657)CAG>AAG	p.Q219K		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	219											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		GAGGTCACATCAGCGTTCTGC	0.363		NA											7	99					5.18e-06	5.37e-06	1	0
DNAH11	8701	broad.mit.edu	37	7	21695520	21695520	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:21695520C>T	uc003svc.2	+	29	5061	c.5030C>T	c.(5029-5031)TCT>TTT	p.S1677F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1677	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CAGGATGTTTCTGCACACAGG	0.403		NA							Kartagener_syndrome				7	49					0	0	0	0
VPS41	27072	broad.mit.edu	37	7	38785177	38785177	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:38785177C>G	uc003tgy.2	-	23	1989	c.1963G>C	c.(1963-1965)GAG>CAG	p.E655Q	VPS41_uc003tgz.2_Missense_Mutation_p.E630Q|VPS41_uc010kxn.2_Missense_Mutation_p.E566Q|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	655	Clathrin.				Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TAAACTGTCTCTTCTACAAAG	0.338		NA											45	154					0	0	0	0
POM121L12	285877	broad.mit.edu	37	7	53103800	53103800	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:53103800C>T	uc003tpz.2	+	1	452	c.436C>T	c.(436-438)CGT>TGT	p.R146C		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	146											0						GCCCCCTGAGCGTCAGGAGAG	0.577		NA											13	29					0	0	0	0
HGF	3082	broad.mit.edu	37	7	81334827	81334827	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:81334827C>G	uc003uhl.2	-	17	2054	c.1889G>C	c.(1888-1890)CGA>CCA	p.R630P	HGF_uc003uhm.2_Missense_Mutation_p.R625P	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	630	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						ATGTGCCACTCGTAATAGGCC	0.368		NA											8	53					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82583504	82583504	+	Silent	SNP	A	A	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:82583504A>C	uc003uhx.2	-	5	7054	c.6765T>G	c.(6763-6765)GGT>GGG	p.G2255G	PCLO_uc003uhv.2_Silent_p.G2255G|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2186					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACTAGCTCTACCATCTGGTG	0.393		NA											9	76					0	0	0	0
ABCB4	5244	broad.mit.edu	37	7	87072722	87072722	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:87072722C>T	uc003uiv.1	-	12	1345	c.1269G>A	c.(1267-1269)CAG>CAA	p.Q423Q	ABCB4_uc003uiw.1_Silent_p.Q423Q|ABCB4_uc003uix.1_Silent_p.Q423Q	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	423	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GGGCCACCGTCTGCCCACTCT	0.493		NA											10	84					0	0	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95434085	95434085	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:95434085A>G	uc003uoc.3	+	2	321	c.44A>G	c.(43-45)AAG>AGG	p.K15R	DYNC1I1_uc003uod.3_Missense_Mutation_p.K15R|DYNC1I1_uc003uob.2_Missense_Mutation_p.K15R|DYNC1I1_uc003uoe.3_Missense_Mutation_p.K15R|DYNC1I1_uc010lfl.2_Missense_Mutation_p.K21R	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	15	Interaction with DCTN1 (By similarity).				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			GAGCGCAAAAAGCAGCGCTTA	0.294		NA											3	5					0	0	0	0
ZAN	7455	broad.mit.edu	37	7	100350144	100350144	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:100350144G>A	uc003uwj.2	+	14	2581	c.2416G>A	c.(2416-2418)GAG>AAG	p.E806K	ZAN_uc003uwk.2_Missense_Mutation_p.E806K|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	806	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CACCCCCACTGAGGAGACCAC	0.527		NA											9	74					0	0	0	0
CUX1	1523	broad.mit.edu	37	7	101813790	101813790	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:101813790C>G	uc003uyx.3	+	10	826	c.788C>G	c.(787-789)TCC>TGC	p.S263C	CUX1_uc003uys.3_Missense_Mutation_p.S274C|CUX1_uc003uyt.2_Missense_Mutation_p.S274C|CUX1_uc011kkn.1_Missense_Mutation_p.S237C|CUX1_uc003uyw.2_Missense_Mutation_p.S228C|CUX1_uc003uyv.2_Missense_Mutation_p.S258C|CUX1_uc003uyu.2_Missense_Mutation_p.S274C	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	263	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GCCAATCACTCCCTCCAGCTG	0.602		NA											2	7					0	0	0	0
ALKBH4	54784	broad.mit.edu	37	7	102100194	102100194	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:102100194C>A	uc003uzl.2	-	2	183	c.178G>T	c.(178-180)GAG>TAG	p.E60*	ALKBH4_uc003uzm.2_Intron	NM_017621	NP_060091	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4	60						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AAGTCAGACTCCTCTGTGCCC	0.493		NA											13	77					1.5e-05	1.55e-05	1	0
PUS7	54517	broad.mit.edu	37	7	105146708	105146708	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:105146708G>A	uc003vcx.2	-	3	630	c.411C>T	c.(409-411)TTC>TTT	p.F137F	PUS7_uc010lji.2_Silent_p.F137F|PUS7_uc003vcy.2_Silent_p.F137F|PUS7_uc003vcz.1_Silent_p.F137F	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	137					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						CATGAACAACGAAGTCGGAGT	0.363		NA											7	34					0	0	0	0
NAMPT	10135	broad.mit.edu	37	7	105893498	105893498	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:105893498C>G	uc003vdq.2	-	10	1638	c.1330G>C	c.(1330-1332)GAG>CAG	p.E444Q		NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	444					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1						TTTCCTTCCTCCAGTGTAACA	0.408		NA											10	55					0	0	0	0
FOXP2	93986	broad.mit.edu	37	7	114329955	114329955	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:114329955G>A	uc003vhb.2	+	17	2496	c.2122G>A	c.(2122-2124)GAG>AAG	p.E708K	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.E733K|FOXP2_uc003vha.2_Missense_Mutation_p.E616K|FOXP2_uc011kmu.1_Missense_Mutation_p.E725K|FOXP2_uc011kmv.1_Missense_Mutation_p.E707K|FOXP2_uc010ljz.1_Missense_Mutation_p.E523K	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	708					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						GATTGAAGAAGAGCCTTTATC	0.438		NA											9	60					0	0	0	0
CADPS2	93664	broad.mit.edu	37	7	122261717	122261717	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:122261717C>G	uc010lkp.2	-	5	1085	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	CADPS2_uc003vkg.3_Missense_Mutation_p.E8Q|CADPS2_uc010lkq.2_Missense_Mutation_p.E308Q	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	308					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						GACCGCAACTCTTCTATATAC	0.299		NA											9	48					0	0	0	0
RBM28	55131	broad.mit.edu	37	7	127975631	127975631	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:127975631C>G	uc003vmp.2	-	8	1027	c.912G>C	c.(910-912)CAG>CAC	p.Q304H	RBM28_uc003vmo.2_5'UTR|RBM28_uc011koj.1_Missense_Mutation_p.Q163H|RBM28_uc011kok.1_Missense_Mutation_p.Q251H	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	304					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TGGTATCACTCTGAGCCAGTT	0.423		NA											5	37					0	0	0	0
NUP205	23165	broad.mit.edu	37	7	135289087	135289087	+	Splice_Site	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:135289087G>C	uc003vsw.2	+	19	2734	c.2703_splice	c.e19-1	p.R901_splice		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						TTTCTTTAAAGATACCTATAT	0.279		NA											7	23					0	0	0	0
BRAF	673	broad.mit.edu	37	7	140453110	140453110	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:140453110G>C	uc003vwc.3	-	15	1886	c.1825C>G	c.(1825-1827)CAG>GAG	p.Q609E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	609	Protein kinase.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.Q609R(1)|p.Q609Q(1)|p.Q609*(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TGTTCAAACTGATGGGACCCA	0.393		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				10	52					0	0	0	0
CUL1	8454	broad.mit.edu	37	7	148495716	148495716	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:148495716G>T	uc010lpg.2	+	20	2609	c.2083G>T	c.(2083-2085)GAA>TAA	p.E695*	CUL1_uc003wey.2_Nonsense_Mutation_p.E695*|CUL1_uc003wez.2_Nonsense_Mutation_p.E585*|CUL1_uc003wfa.2_Nonsense_Mutation_p.E356*	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	695					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ACAGAAGCAGGAACAAGAAAC	0.418		NA											14	72					1.15e-07	1.21e-07	1	0
ZNF425	155054	broad.mit.edu	37	7	148801943	148801943	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:148801943G>A	uc003wfj.2	-	4	1093	c.1020C>T	c.(1018-1020)CGC>CGT	p.R340R		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	340	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCCTCTTCAGGCGGAAGCACC	0.662		NA											9	38					0	0	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327212	150327212	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:150327212C>G	uc003whn.2	-	2	443	c.19G>C	c.(19-21)GAA>CAA	p.E7Q	GIMAP6_uc003whm.2_Missense_Mutation_p.M1I	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	7							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAATTTGTTCATATTCTTCT	0.428		NA											3	89					0	0	0	0
RNF32	140545	broad.mit.edu	37	7	156437207	156437207	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr7:156437207G>C	uc003wmo.2	+	3	212	c.30G>C	c.(28-30)AAG>AAC	p.K10N	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Missense_Mutation_p.K10N|RNF32_uc003wmp.2_Missense_Mutation_p.K10N|RNF32_uc003wmq.2_Missense_Mutation_p.K10N|RNF32_uc003wmr.2_Missense_Mutation_p.K10N|RNF32_uc003wms.2_Missense_Mutation_p.K10N|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Missense_Mutation_p.K10N	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	10						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		ACTCATCTAAGAAAGATAACT	0.333		NA											5	53					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	2823375	2823375	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:2823375C>A	uc011kwk.1	-	59	9595	c.9205G>T	c.(9205-9207)GTC>TTC	p.V3069F	CSMD1_uc011kwj.1_Missense_Mutation_p.V2398F|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3069	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTTCCATGACATAGCCTGGG	0.493		NA											9	6					2.18e-05	2.25e-05	1	0
SOX7	83595	broad.mit.edu	37	8	10583925	10583925	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:10583925C>G	uc003wtf.2	-	2	569	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	SOX7_uc011kwz.1_Missense_Mutation_p.E216Q|uc003wtg.1_5'Flank	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	164					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGGGAGTACTCACCCCTGTCC	0.726		NA											8	15					0	0	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19297418	19297418	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:19297418C>T	uc011kyn.1	-	6	1940	c.876G>A	c.(874-876)GGG>GGA	p.G292G	CSGALNACT1_uc011kyo.1_Silent_p.G292G|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.G291G|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	292	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		GATGGACTCTCCCATCCTGCT	0.418		NA											17	36					0	0	0	0
FAM160B2	64760	broad.mit.edu	37	8	21960135	21960135	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:21960135G>A	uc011kyx.1	+	16	2140	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	697											0						GGCTCCTGGGGAGCAGTGAGT	0.622		NA											5	4					0	0	0	0
ADAM7	8756	broad.mit.edu	37	8	24356805	24356805	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:24356805C>T	uc003xeb.2	+	17	2012	c.1899C>T	c.(1897-1899)TGC>TGT	p.C633C	ADAM7_uc003xec.2_Silent_p.C405C	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	633	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CAACCAATTGCCCCTCTCAGT	0.328		NA											3	46					0	0	0	0
EBF2	64641	broad.mit.edu	37	8	25708194	25708194	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:25708194G>C	uc003xes.1	-	15	1629	c.1612C>G	c.(1612-1614)CAG>GAG	p.Q538E	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	538					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GCACTCTTCTGTTTGACAGCA	0.522		NA											41	70					0	0	0	0
UBXN8	7993	broad.mit.edu	37	8	30608921	30608921	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:30608921G>A	uc003xii.2	+	2	114	c.97G>A	c.(97-99)GAT>AAT	p.D33N	UBXN8_uc010lvi.2_Intron|UBXN8_uc011lbb.1_RNA|UBXN8_uc003xij.2_RNA	NM_005671	NP_005662	O00124	UBXN8_HUMAN	reproduction 8	33					single fertilization						0						AGGAATCAAGGATTTTCTTTT	0.244		NA											3	18					0	0	0	0
C8orf41	80185	broad.mit.edu	37	8	33369604	33369604	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:33369604G>A	uc003xjl.3	-	1	1053	c.528C>T	c.(526-528)CTC>CTT	p.L176L	C8orf41_uc003xjk.3_Silent_p.L176L|C8orf41_uc010lvv.2_Silent_p.L176L|C8orf41_uc003xjm.3_Silent_p.L176L|C8orf41_uc003xjn.1_Silent_p.L176L	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	176							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		GCAGTGAGGTGAGCACCTCCC	0.493		NA											6	269					0	0	0	0
PRKDC	5591	broad.mit.edu	37	8	48719860	48719860	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:48719860C>G	uc003xqi.2	-	70	9642	c.9585G>C	c.(9583-9585)GAG>GAC	p.E3195D	PRKDC_uc003xqj.2_Missense_Mutation_p.E3195D|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3195	KIP-binding.|FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGGTAAGCTTCTCCTCTATTT	0.423		NA						NHEJ					46	127					0	0	0	0
PRKDC	5591	broad.mit.edu	37	8	48777319	48777319	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:48777319G>T	uc003xqi.2	-	42	5426	c.5369C>A	c.(5368-5370)TCA>TAA	p.S1790*	PRKDC_uc003xqj.2_Nonsense_Mutation_p.S1790*|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1790					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTGACACATGAACCCCTAAG	0.443		NA						NHEJ					3	14					6.4e-05	6.59e-05	1	0
MCM4	4173	broad.mit.edu	37	8	48883280	48883280	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:48883280G>A	uc003xqk.1	+	12	1739	c.1644G>A	c.(1642-1644)ATG>ATA	p.M548I	MCM4_uc003xql.1_Missense_Mutation_p.M548I|MCM4_uc011ldi.1_Missense_Mutation_p.M535I	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	548	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CGTACGTAATGAAAGACCCTG	0.552		NA											14	41					0	0	0	0
PXDNL	137902	broad.mit.edu	37	8	52284541	52284541	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:52284541G>A	uc003xqu.3	-	19	3894	c.3793C>T	c.(3793-3795)CAG>TAG	p.Q1265*	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1265					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGCACTTGCTGAATGCTGTCA	0.532		NA											5	26					0	0	0	0
MYBL1	4603	broad.mit.edu	37	8	67504755	67504755	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:67504755C>T	uc003xwj.2	-	8	1194	c.787G>A	c.(787-789)GAT>AAT	p.D263N	MYBL1_uc003xwl.2_Missense_Mutation_p.D263N|MYBL1_uc003xwk.2_Missense_Mutation_p.D263N	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	263	Transcriptional activation domain (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			TTTTCCTTATCAGGATCTTCA	0.284		NA											6	89					0	0	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68150972	68150972	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:68150972C>T	uc003xxo.1	-	21	3526	c.3136G>A	c.(3136-3138)GAG>AAG	p.E1046K	ARFGEF1_uc003xxl.1_Missense_Mutation_p.E500K|ARFGEF1_uc003xxn.1_Missense_Mutation_p.E29K	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1046					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCTTATACCTCATGCCATGAA	0.323		NA											24	76					0	0	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68165736	68165736	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:68165736G>A	uc003xxo.1	-	18	3038	c.2648C>T	c.(2647-2649)TCA>TTA	p.S883L	ARFGEF1_uc003xxl.1_Missense_Mutation_p.S337L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	883					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TTCTTTCATTGATATCTTTTT	0.308		NA											6	62					0	0	0	0
TERF1	7013	broad.mit.edu	37	8	73942628	73942628	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:73942628G>A	uc003xzd.2	+	7	970	c.945G>A	c.(943-945)TTG>TTA	p.L315L	TERF1_uc003xze.2_Intron	NM_017489	NP_059523	P54274	TERF1_HUMAN	telomeric repeat binding factor 1 isoform 1	315	Interaction with RLIM.				age-dependent telomere shortening|cell division|G2/M transition of mitotic cell cycle|induction of apoptosis|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of telomere maintenance via semi-conservative replication|negative regulation of telomere maintenance via telomerase|positive regulation of microtubule polymerization|positive regulation of mitosis|positive regulation of mitotic cell cycle|protein homooligomerization|regulation of transcription, DNA-dependent|telomere maintenance via telomerase|telomere maintenance via telomerase|telomere maintenance via telomere shortening	chromosome, telomeric region|cytoplasm|nuclear telomere cap complex|nucleoplasm|nucleus|spindle	caspase activator activity|DNA bending activity|double-stranded telomeric DNA binding|identical protein binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|telomerase inhibitor activity|telomeric DNA binding			ovary(1)|lung(1)|skin(1)	3	Breast(64;0.218)		Epithelial(68;0.0984)			TATCCTTATTGAGGTGAAGTA	0.318		NA											6	28					0	0	0	0
TCEB1	6921	broad.mit.edu	37	8	74859029	74859029	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:74859029C>T	uc003xzx.1	-	4	260	c.175G>A	c.(175-177)GAG>AAG	p.E59K	TCEB1_uc003xzy.1_Missense_Mutation_p.E59K|TCEB1_uc003xzz.1_Missense_Mutation_p.E43K|TCEB1_uc003yaa.1_Missense_Mutation_p.E59K	NM_005648	NP_005639	Q15369	ELOC_HUMAN	elongin C	59					interspecies interaction between organisms|positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm	protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0136)|all cancers(69;0.0431)|BRCA - Breast invasive adenocarcinoma(89;0.0499)			AAATTGACCTCATTGGTTTCG	0.289		NA											18	55					0	0	0	0
JPH1	56704	broad.mit.edu	37	8	75227373	75227373	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:75227373C>T	uc003yae.2	-	2	902	c.862G>A	c.(862-864)GAC>AAC	p.D288N	JPH1_uc003yaf.2_Missense_Mutation_p.D288N|JPH1_uc003yag.1_Missense_Mutation_p.D152N	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	288	Cytoplasmic (Potential).|MORN 6.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TTGCGCTTGTCGTTCTTCCAC	0.542		NA											50	122					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617904	77617904	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:77617904G>A	uc003yav.2	+	2	1968	c.1581G>A	c.(1579-1581)GCG>GCA	p.A527A	ZFHX4_uc003yat.1_Silent_p.A527A|ZFHX4_uc003yau.1_Silent_p.A527A|ZFHX4_uc003yaw.1_Silent_p.A527A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	527						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCTCCTCGGCGACTGTTTCTG	0.433		NA								HNSCC(33;0.089)			14	57					0	0	0	0
TPD52	7163	broad.mit.edu	37	8	80976724	80976724	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:80976724C>G	uc003ybr.1	-	2	566	c.244G>C	c.(244-246)GAA>CAA	p.E82Q	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Missense_Mutation_p.E42Q|TPD52_uc003ybt.1_Missense_Mutation_p.E42Q|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	82	Potential.				anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TTTGCAAGTTCTCTTCTTAGC	0.428		NA											43	105					0	0	0	0
RBM12B	389677	broad.mit.edu	37	8	94746326	94746326	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:94746326G>A	uc003yfz.2	-	3	2506	c.2313C>T	c.(2311-2313)TTC>TTT	p.F771F		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	771							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GCGGGCGCCTGAAATGCTCTG	0.662		NA											25	88					0	0	0	0
ESRP1	54845	broad.mit.edu	37	8	95690463	95690463	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:95690463C>T	uc003ygq.3	+	13	1867	c.1684C>T	c.(1684-1686)CCT>TCT	p.P562S	ESRP1_uc003ygr.3_Missense_Mutation_p.P558S|ESRP1_uc003ygs.3_Missense_Mutation_p.P558S|ESRP1_uc003ygt.3_Missense_Mutation_p.P562S|ESRP1_uc003ygu.3_Missense_Mutation_p.P558S|ESRP1_uc003ygv.2_Missense_Mutation_p.P402S|ESRP1_uc003ygw.2_Missense_Mutation_p.P402S	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	562					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						ATTTCCAGCTCCTGCTGCAGT	0.493		NA											24	81					0	0	0	0
NIPAL2	79815	broad.mit.edu	37	8	99215352	99215352	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:99215352G>C	uc003yil.1	-	8	1120	c.864C>G	c.(862-864)ATC>ATG	p.I288M	NIPAL2_uc011lgw.1_Missense_Mutation_p.I84M|NIPAL2_uc003yim.1_Missense_Mutation_p.I288M	NM_024759	NP_079035	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	288	Helical; (Potential).					integral to membrane					0						TGATGGCACTGATTGTAAAGA	0.398		NA											23	38					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100654378	100654378	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:100654378G>A	uc003yiv.2	+	34	5746	c.5635G>A	c.(5635-5637)GAA>AAA	p.E1879K	VPS13B_uc003yiw.2_Missense_Mutation_p.E1854K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1879					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAATCTCCCAGAAGTTGATTC	0.388		NA											20	189					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100844830	100844830	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:100844830G>C	uc003yiv.2	+	52	9750	c.9639G>C	c.(9637-9639)CAG>CAC	p.Q3213H	VPS13B_uc003yiw.2_Missense_Mutation_p.Q3188H	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3213					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTCCCAGACAGAGTGTGGCAG	0.473		NA											23	104					0	0	0	0
YWHAZ	7534	broad.mit.edu	37	8	101936232	101936232	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:101936232G>A	uc011lhe.1	-	5	806	c.629C>T	c.(628-630)TCA>TTA	p.S210L	YWHAZ_uc003yjv.2_Missense_Mutation_p.S210L|YWHAZ_uc011lhf.1_Missense_Mutation_p.S210L|YWHAZ_uc003yjw.2_Missense_Mutation_p.S210L|YWHAZ_uc010mbq.2_Missense_Mutation_p.S133L|YWHAZ_uc011lhg.1_Missense_Mutation_p.S90L|YWHAZ_uc010mbr.2_Missense_Mutation_p.S210L|YWHAZ_uc003yjx.2_Missense_Mutation_p.S210L|YWHAZ_uc003yjy.2_Missense_Mutation_p.S210L	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	210					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	GTCTTTGTATGACTCTTCACT	0.343		NA											42	159					0	0	0	0
NCALD	83988	broad.mit.edu	37	8	102701558	102701558	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:102701558C>T	uc003yke.2	-	4	930	c.561G>A	c.(559-561)CCG>CCA	p.P187P	NCALD_uc003ykf.2_Silent_p.P187P|NCALD_uc003ykg.2_Silent_p.P187P|NCALD_uc003ykh.2_Silent_p.P187P|NCALD_uc003yki.2_Silent_p.P187P|NCALD_uc003ykj.2_Silent_p.P187P|NCALD_uc003ykk.2_Silent_p.P187P|NCALD_uc003ykl.2_Silent_p.P187P	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	187					synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CGGCACTGCTCGGGTCGCACT	0.502		NA											5	27					0	0	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119940992	119940992	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:119940992G>C	uc003yon.3	-	3	900	c.577C>G	c.(577-579)CAA>GAA	p.Q193E	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	193					apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			CCACATTTTTGAGTTGATTCA	0.393		NA											4	200					0	0	0	0
SNTB1	6641	broad.mit.edu	37	8	121823639	121823639	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:121823639C>T	uc010mdg.2	-	1	671	c.445G>A	c.(445-447)GAC>AAC	p.D149N	SNTB1_uc003ype.2_Missense_Mutation_p.D149N	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	149	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGGTCTGGTCCGCCGCCAGC	0.657		NA											22	88					0	0	0	0
WDR67	93594	broad.mit.edu	37	8	124140671	124140671	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:124140671C>A	uc003ypp.1	+	14	2125	c.2035C>A	c.(2035-2037)CAA>AAA	p.Q679K	WDR67_uc011lig.1_Missense_Mutation_p.Q679K|WDR67_uc011lih.1_Missense_Mutation_p.Q569K|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Intron|WDR67_uc003ypt.1_Missense_Mutation_p.Q136K|WDR67_uc003ypu.1_Missense_Mutation_p.Q136K	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	679						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AGTATTTAATCAATATCCAAA	0.358		NA											36	63					1.84e-18	1.97e-18	1	0
KLHL38	340359	broad.mit.edu	37	8	124664436	124664436	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:124664436G>A	uc003yqs.1	-	1	755	c.731C>T	c.(730-732)TCC>TTC	p.S244F		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	244											0						TGCAGGCGAGGACTGCAGGAG	0.552		NA											19	80					0	0	0	0
FER1L6	654463	broad.mit.edu	37	8	125072457	125072457	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:125072457G>C	uc003yqw.2	+	23	3117	c.2911G>C	c.(2911-2913)GAG>CAG	p.E971Q	uc003yqy.1_RNA	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	971	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCCACCCGTTGAGCCACCAGA	0.582		NA											41	119					0	0	0	0
TMEM71	137835	broad.mit.edu	37	8	133740154	133740154	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:133740154G>A	uc003ytp.2	-	6	792	c.563C>T	c.(562-564)TCT>TTT	p.S188F	TMEM71_uc003ytm.1_Missense_Mutation_p.S10F|TMEM71_uc003ytn.2_Missense_Mutation_p.S170F|TMEM71_uc003yto.2_Intron	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	189						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GTGGCTGGAAGAGGAGGTGAT	0.473		NA											16	144					0	0	0	0
CYP11B2	1585	broad.mit.edu	37	8	143993975	143993975	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:143993975C>G	uc003yxk.1	-	8	1372	c.1369G>C	c.(1369-1371)GAG>CAG	p.E457Q		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	457					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	ATCTCTGCCTCTGCCAGGCGC	0.692		NA							Familial_Hyperaldosteronism_type_I				15	69					0	0	0	0
ZNF623	9831	broad.mit.edu	37	8	144732148	144732148	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:144732148G>A	uc003yzd.2	+	1	195	c.106G>A	c.(106-108)GAC>AAC	p.D36N	ZNF623_uc011lkp.1_5'UTR|ZNF623_uc003yzc.2_5'UTR	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	36					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GACGACGTCAGACAGACTCAC	0.502		NA											41	74					0	0	0	0
EPPK1	83481	broad.mit.edu	37	8	144941431	144941431	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:144941431G>A	uc003zaa.1	-	1	6004	c.5991C>T	c.(5989-5991)CTC>CTT	p.L1997L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1997	Plectin 33.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTTCTCGATGAGCTGCTTCT	0.647		NA											11	30					0	0	0	0
ZNF16	7564	broad.mit.edu	37	8	146157135	146157135	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:146157135C>T	uc003zet.2	-	4	1225	c.1038G>A	c.(1036-1038)GAG>GAA	p.E346E	ZNF16_uc003zeu.2_Silent_p.E346E	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		CATACGGTTTCTCCCCAGAAT	0.488		NA											15	81					0	0	0	0
C9orf68	55064	broad.mit.edu	37	9	4605410	4605410	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:4605410C>T	uc011llz.1	-	9	1090	c.852G>A	c.(850-852)AAG>AAA	p.K284K	C9orf68_uc003zik.2_RNA|C9orf68_uc003zil.2_RNA|C9orf68_uc010mhj.2_Silent_p.K342K|C9orf68_uc011lly.1_Silent_p.K219K	NM_001039395	NP_001034484	B4DIY4	B4DIY4_HUMAN	hypothetical protein LOC55064	284											0		Breast(48;0.0456)		GBM - Glioblastoma multiforme(50;0.0222)		CATGGATATTCTTCCATGTGG	0.343		NA											20	79					0	0	0	0
CNTLN	54875	broad.mit.edu	37	9	17143343	17143343	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:17143343C>G	uc003zmz.2	+	2	444	c.418C>G	c.(418-420)CTC>GTC	p.L140V	CNTLN_uc003zmx.3_Missense_Mutation_p.L140V|CNTLN_uc003zmy.2_Missense_Mutation_p.L140V|CNTLN_uc003zmw.1_Missense_Mutation_p.L140V	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	140						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		AAACCCAGATCTCACACAAGT	0.348		NA											5	178					0	0	0	0
KIF24	347240	broad.mit.edu	37	9	34290296	34290296	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:34290296G>A	uc003zua.3	-	5	1123	c.1003C>T	c.(1003-1005)CTA>TTA	p.L335L	KIF24_uc010mkb.2_Silent_p.L366L	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	335	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			TTGGCAGCTAGAGCATACAAT	0.458		NA											60	51					0	0	0	0
KIF27	55582	broad.mit.edu	37	9	86518637	86518637	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:86518637G>C	uc004ana.2	-	4	940	c.796C>G	c.(796-798)CAA>GAA	p.Q266E	KIF27_uc010mpw.2_Missense_Mutation_p.Q266E|KIF27_uc010mpx.2_Missense_Mutation_p.Q266E	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	266	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						CTATTGATTTGAATGGATTCT	0.428		NA											30	81					0	0	0	0
NTRK2	4915	broad.mit.edu	37	9	87482318	87482318	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:87482318C>T	uc004aoa.1	+	15	2495	c.1557C>T	c.(1555-1557)ATC>ATT	p.I519I	NTRK2_uc004any.1_Silent_p.I519I|NTRK2_uc004anz.1_Silent_p.I535I|NTRK2_uc011lsz.1_Silent_p.I535I|NTRK2_uc011lta.1_Silent_p.I519I|NTRK2_uc004aoc.2_Silent_p.I70I	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	519	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						ACTTTGGCATCACCAACAGTC	0.453		NA								TSP Lung(25;0.17)			35	93					0	0	0	0
NOL8	55035	broad.mit.edu	37	9	95077643	95077643	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:95077643C>T	uc004arv.2	-	7	1601	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.D354N	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	422					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						ATACAGTGATCAGAAAGCTCA	0.333		NA											7	30					0	0	0	0
NOL8	55035	broad.mit.edu	37	9	95077919	95077919	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:95077919C>T	uc004arv.2	-	7	1325	c.988G>A	c.(988-990)GAA>AAA	p.E330K	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.E262K	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	330					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						GGATCACTTTCAGATTCATTT	0.353		NA											21	35					0	0	0	0
ZNF484	83744	broad.mit.edu	37	9	95610741	95610741	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:95610741C>T	uc004asu.1	-	5	477	c.328G>A	c.(328-330)GAC>AAC	p.D110N	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.D112N|ZNF484_uc010mrb.1_Missense_Mutation_p.D74N|ZNF484_uc004asv.1_Missense_Mutation_p.D74N	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	110					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAATATGGGTCATCTCTTGTG	0.353		NA											39	110					0	0	0	0
GABBR2	9568	broad.mit.edu	37	9	101304180	101304180	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:101304180G>A	uc004ays.2	-	3	761	c.605C>T	c.(604-606)ACG>ATG	p.T202M		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	202	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	AACGTCTTGCGTCAGCGTGCC	0.532		NA											9	48					0	0	0	0
GALNT12	79695	broad.mit.edu	37	9	101608279	101608279	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:101608279G>C	uc004ayz.2	+	9	1479	c.1479G>C	c.(1477-1479)CAG>CAC	p.Q493H		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	493	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				ACACGTCCCAGAAAGAAATAC	0.483		NA											11	41					0	0	0	0
COL15A1	1306	broad.mit.edu	37	9	101763192	101763192	+	Missense_Mutation	SNP	G	G	C	rs137949756		TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:101763192G>C	uc004azb.1	+	7	1230	c.1024G>C	c.(1024-1026)GGC>CGC	p.G342R		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	342	Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding	p.G342S(1)		ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TACTGACAGCGGCTCAGGGGC	0.468		NA									OREG0019364	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	54					0	0	0	0
OR13C3	138803	broad.mit.edu	37	9	107298345	107298345	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:107298345G>A	uc004bcb.1	-	1	750	c.750C>T	c.(748-750)TTC>TTT	p.F250F		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	250	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TGTAGAGGATGAACATATAGG	0.428		NA											37	81					0	0	0	0
OR13D1	286365	broad.mit.edu	37	9	107456838	107456838	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:107456838C>G	uc011lvs.1	+	1	136	c.136C>G	c.(136-138)CTG>GTG	p.L46V		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	46	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGAATTCTTTCTGGTGGGGCT	0.438		NA											27	69					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899402	112899402	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:112899402C>G	uc004bei.2	+	9	2466	c.2274C>G	c.(2272-2274)CTC>CTG	p.L758L	PALM2-AKAP2_uc004bek.3_Silent_p.L526L|PALM2-AKAP2_uc004bej.3_Silent_p.L526L|PALM2-AKAP2_uc004bel.1_Silent_p.L336L|AKAP2_uc011lwi.1_Silent_p.L384L|AKAP2_uc004bem.2_Silent_p.L384L|PALM2-AKAP2_uc010mtw.1_Silent_p.L344L|AKAP2_uc011lwj.1_Silent_p.L295L|PALM2-AKAP2_uc004ben.2_Silent_p.L295L	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	295							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CATCGCAGCTCTGCACAGCCC	0.378		NA											10	22					0	0	0	0
SUSD1	64420	broad.mit.edu	37	9	114875121	114875121	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:114875121G>C	uc004bfu.2	-	7	955	c.914C>G	c.(913-915)TCA>TGA	p.S305*	SUSD1_uc010mui.2_Nonsense_Mutation_p.S305*|SUSD1_uc010muj.2_Nonsense_Mutation_p.S305*	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	305	Extracellular (Potential).					integral to membrane	calcium ion binding				0						ATTAAACAGTGATACATCATT	0.343		NA											23	52					0	0	0	0
FKBP15	23307	broad.mit.edu	37	9	115952852	115952852	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:115952852C>T	uc004bgs.2	-	12	1190	c.1072G>A	c.(1072-1074)GAT>AAT	p.D358N	FKBP15_uc010muu.1_Missense_Mutation_p.D422N|FKBP15_uc011lxc.1_5'Flank|FKBP15_uc011lxd.1_Missense_Mutation_p.D290N|FKBP15_uc010mut.1_Missense_Mutation_p.D226N|FKBP15_uc004bgt.2_Missense_Mutation_p.D358N	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	358					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						TTGACTGCATCGGGACTCTAA	0.458		NA											5	6					0	0	0	0
TNC	3371	broad.mit.edu	37	9	117848518	117848518	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:117848518C>T	uc004bjj.3	-	3	1854	c.1492G>A	c.(1492-1494)GAT>AAT	p.D498N	TNC_uc010mvf.2_Missense_Mutation_p.D498N	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	498	EGF-like 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						CATTGGCGATCCCGGCAGTCT	0.602		NA											43	140					0	0	0	0
CEP110	11064	broad.mit.edu	37	9	123924347	123924347	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:123924347G>C	uc004bkx.1	+	32	5252	c.5221G>C	c.(5221-5223)GAG>CAG	p.E1741Q	CEP110_uc004blb.1_Missense_Mutation_p.E410Q|CEP110_uc010mvp.1_Intron	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1741	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ACTGGAGTTAGAGAATTTGCA	0.413		NA											20	70					0	0	0	0
TTLL11	158135	broad.mit.edu	37	9	124794104	124794104	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:124794104C>T	uc004blt.1	-	3	1049	c.861G>A	c.(859-861)CTG>CTA	p.L287L	TTLL11_uc011lyl.1_Silent_p.L287L|TTLL11_uc004blr.2_Intron|TTLL11_uc011lym.1_Intron|TTLL11_uc004blu.1_Intron	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	287	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						CTGCTCTGCTCAGAGTAATTT	0.478		NA											32	99					0	0	0	0
RABEPK	10244	broad.mit.edu	37	9	127990317	127990317	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:127990317G>A	uc004bpi.2	+	7	828	c.655G>A	c.(655-657)GAC>AAC	p.D219N	RABEPK_uc004bpj.2_Missense_Mutation_p.D168N|RABEPK_uc004bpk.2_Missense_Mutation_p.D219N|RABEPK_uc004bpl.1_Missense_Mutation_p.D168N|RABEPK_uc004bpm.2_Missense_Mutation_p.D219N	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	219	Kelch 4.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						ATTCTATGATGACCTCCACTG	0.403		NA											13	26					0	0	0	0
LRSAM1	90678	broad.mit.edu	37	9	130263396	130263396	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:130263396G>C	uc004brb.1	+	25	2365	c.2020G>C	c.(2020-2022)GAG>CAG	p.E674Q	LRSAM1_uc010mxk.1_Missense_Mutation_p.E647Q|LRSAM1_uc004brc.1_Missense_Mutation_p.E674Q|LRSAM1_uc004brd.1_Missense_Mutation_p.E674Q|LRSAM1_uc004bre.1_Missense_Mutation_p.E254Q|LRSAM1_uc004brg.1_Missense_Mutation_p.E105Q	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	674					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GCAGGCCTCAGAGTGTGTCGT	0.662		NA											13	35					0	0	0	0
LRRC8A	56262	broad.mit.edu	37	9	131671590	131671590	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:131671590C>T	uc004bwl.3	+	3	2401	c.2147C>T	c.(2146-2148)ACG>ATG	p.T716M	LRRC8A_uc010myp.2_Missense_Mutation_p.T716M|LRRC8A_uc010myq.2_Missense_Mutation_p.T716M	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	716	LRR 15.				pre-B cell differentiation	integral to membrane					0						CTAGCCATCACGGCCAACCGG	0.667		NA											29	71					0	0	0	0
RALGDS	5900	broad.mit.edu	37	9	135975666	135975666	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:135975666G>C	uc004cco.2	-	17	2578	c.2558C>G	c.(2557-2559)TCA>TGA	p.S853*	RALGDS_uc004cct.1_5'Flank|RALGDS_uc004ccn.2_Nonsense_Mutation_p.S41*|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Nonsense_Mutation_p.S841*|RALGDS_uc004ccr.2_Nonsense_Mutation_p.S852*|RALGDS_uc011mcv.1_Nonsense_Mutation_p.S824*|RALGDS_uc004ccs.2_Nonsense_Mutation_p.S798*|RALGDS_uc011mcw.1_Nonsense_Mutation_p.S924*|RALGDS_uc004ccv.1_3'UTR|RALGDS_uc004ccu.1_3'UTR	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	853	Ras-associating.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CCGGTCATCTGAGAGAATCTG	0.582		NA	T	CIITA	PMBL|Hodgkin Lymphona|								79	253					0	0	0	0
C9orf116	138162	broad.mit.edu	37	9	138391608	138391608	+	Silent	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:138391608C>G	uc004cft.1	-	1	154	c.90G>C	c.(88-90)GTG>GTC	p.V30V	C9orf116_uc004cfs.1_Silent_p.V30V|C9orf116_uc004cfu.1_RNA|MRPS2_uc004cfv.3_5'Flank|MRPS2_uc004cfw.3_5'Flank|MRPS2_uc004cfx.3_5'Flank|MRPS2_uc010nat.2_5'Flank	NM_001048265	NP_001041730	Q5BN46	CI116_HUMAN	hypothetical protein LOC138162 isoform 1	30											0				OV - Ovarian serous cystadenocarcinoma(145;7.39e-08)|Epithelial(140;5.19e-07)|all cancers(34;1.04e-05)		GGTCCGCGCTCACGCGGTAGT	0.697		NA											3	19					0	0	0	0
C8G	733	broad.mit.edu	37	9	139840549	139840549	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr9:139840549G>A	uc004cka.2	+	4	434	c.359G>A	c.(358-360)CGA>CAA	p.R120Q	FBXW5_uc004cjx.2_5'Flank|FBXW5_uc004cjy.2_5'Flank|FBXW5_uc004cjz.2_5'Flank	NM_000606	NP_000597	P07360	CO8G_HUMAN	complement component 8, gamma polypeptide	120					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex	retinol binding|transporter activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.88e-06)|Epithelial(140;0.000107)		CGAGACGCCCGAGGGGCTGTG	0.642		NA											16	23					0	0	0	0
ASMTL	8623	broad.mit.edu	37	X	1546743	1546743	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:1546743C>T	uc004cpx.1	-	7	892	c.781G>A	c.(781-783)GAG>AAG	p.E261K	ASMTL_uc011mhe.1_Missense_Mutation_p.E185K|ASMTL_uc004cpy.1_Missense_Mutation_p.E245K|ASMTL_uc011mhf.1_Missense_Mutation_p.E203K	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	261					melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTCCCGCCTCGGCCTTCTCA	0.697		NA											7	57					0	0	0	0
TBL1X	6907	broad.mit.edu	37	X	9679750	9679750	+	Silent	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:9679750C>T	uc010ndq.2	+	16	1907	c.1539C>T	c.(1537-1539)TTC>TTT	p.F513F	TBL1X_uc004csq.3_Silent_p.F462F|TBL1X_uc010ndr.2_Silent_p.F462F|TBL1X_uc004csr.2_Silent_p.F513F|TBL1X_uc004css.2_Silent_p.F464F	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	513	WD 7.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				GCGTAGCTTTCAGCCCTGATG	0.527		NA											15	21					0	0	0	0
CDKL5	6792	broad.mit.edu	37	X	18646649	18646649	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:18646649G>A	uc004cym.2	+	18	2908	c.2655G>A	c.(2653-2655)GGG>GGA	p.G885G	CDKL5_uc004cyn.2_Silent_p.G885G	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	885					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CCTCTGGCGGGAGCAGCAACA	0.592		NA											43	47					0	0	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19764535	19764535	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:19764535C>T	uc004czm.2	-	3	503	c.187G>A	c.(187-189)GAC>AAC	p.D63N	SH3KBP1_uc004czl.2_Missense_Mutation_p.D26N	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	63					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GTGAGAGGGTCTTTCTTCATC	0.403		NA											54	51					0	0	0	0
OTUD5	55593	broad.mit.edu	37	X	48783269	48783269	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:48783269C>G	uc004dlu.2	-	6	1193	c.1132G>C	c.(1132-1134)GAA>CAA	p.E378Q	OTUD5_uc004dlt.3_Missense_Mutation_p.E373Q|OTUD5_uc004dlv.2_Missense_Mutation_p.E373Q|OTUD5_uc011mmp.1_Missense_Mutation_p.E156Q	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	378					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						ATCTGCTGTTCAATCCATGAC	0.507		NA											8	45					0	0	0	0
CCNB3	85417	broad.mit.edu	37	X	50094305	50094305	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:50094305G>A	uc004dox.3	+	12	4324	c.4026G>A	c.(4024-4026)CTG>CTA	p.L1342L	CCNB3_uc004doy.2_Silent_p.L1342L|CCNB3_uc004doz.2_Silent_p.L238L|CCNB3_uc010njq.2_Silent_p.L234L|CCNB3_uc004dpa.2_Silent_p.L181L	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1342					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TCAGACAGCTGAACAAACTGC	0.458		NA											71	49					0	0	0	0
EFNB1	1947	broad.mit.edu	37	X	68058466	68058466	+	Silent	SNP	G	G	A			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:68058466G>A	uc004dxd.3	+	2	915	c.135G>A	c.(133-135)CTG>CTA	p.L45L	EFNB1_uc004dxe.2_Silent_p.L45L	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	45	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						GCAGGTTCCTGAGTGGGAAGG	0.592		NA											17	11					0	0	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69424864	69424864	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:69424864C>G	uc004dxx.1	+	7	1019	c.922C>G	c.(922-924)CAC>GAC	p.H308D		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	308					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						AGACAAGTATCACGCACTCTA	0.468		NA											18	18					0	0	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927287	92927287	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:92927287G>C	uc004efq.2	-	1	1322	c.1017C>G	c.(1015-1017)TTC>TTG	p.F339L	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	339					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						CATCCGACAAGAACTTCAGAA	0.423		NA											14	27					0	0	0	0
GUCY2F	2986	broad.mit.edu	37	X	108625366	108625366	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:108625366C>G	uc004eod.3	-	17	3407	c.3131G>C	c.(3130-3132)CGA>CCA	p.R1044P	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1044	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TGTTCTTCCTCGAAGCTCCAC	0.423		NA											3	166					0	0	0	0
WDR44	54521	broad.mit.edu	37	X	117530989	117530989	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:117530989G>C	uc004eqn.2	+	7	1535	c.1110G>C	c.(1108-1110)TTG>TTC	p.L370F	WDR44_uc004eqo.2_Missense_Mutation_p.L370F|WDR44_uc011mtr.1_Missense_Mutation_p.L345F|WDR44_uc010nqi.2_Missense_Mutation_p.L80F	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	370						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						AAATACCTTTGAGTCTTGCAG	0.363		NA											33	42					0	0	0	0
ODZ1	10178	broad.mit.edu	37	X	123514646	123514646	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:123514646C>G	uc004euj.2	-	31	7982	c.7918G>C	c.(7918-7920)GAA>CAA	p.E2640Q	ODZ1_uc011muj.1_Missense_Mutation_p.E2646Q|ODZ1_uc010nqy.2_Missense_Mutation_p.E2647Q	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2640	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTTTCCTCTTCGACAGTTGTC	0.532		NA											3	83					0	0	0	0
EMD	2010	broad.mit.edu	37	X	153608306	153608306	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chrX:153608306G>C	uc004fkl.2	+	3	440	c.192G>C	c.(190-192)TTG>TTC	p.L64F		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin	64	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATCCAGACTTGAATTCGACTA	0.567		NA											69	100					0	0	0	0
KIAA1199	57214	broad.mit.edu	37	15	81171075	81171075	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr15:81171075delC	uc002bfw.1	+	3	368	c.108delC	c.(106-108)TGCfs	p.C36fs	KIAA1199_uc010unn.1_Frame_Shift_Del_p.C36fs	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	36										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTGCTGGGTGCCCTGACCAGA	0.582		NA											11	77	---	---	---	---	NA	NA	NA	NA
COL25A1	84570	broad.mit.edu	37	4	109780855	109780856	+	Frame_Shift_Ins	INS	-	-	TGGC			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr4:109780855_109780856insTGGC	uc003hze.1	-	23	1807_1808	c.1276_1277insGCCA	c.(1276-1278)ACTfs	p.T426fs	COL25A1_uc003hzg.2_Frame_Shift_Ins_p.T426fs|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Frame_Shift_Ins_p.T192fs	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	426	Extracellular (Potential).					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TATGATCTCAGTGGCTCCTTGA	0.51		NA											11	70	---	---	---	---	NA	NA	NA	NA
SFTPC	6440	broad.mit.edu	37	8	22021060	22021061	+	Splice_Site	DEL	GT	GT	-			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:22021060_22021061delGT	uc003xax.3	+	4	593	c.435_splice	c.e4+1	p.Q145_splice	SFTPC_uc003xaw.3_Splice_Site_p.Q194_splice|SFTPC_uc011kza.1_Intron|SFTPC_uc003xaz.2_Splice_Site_p.Q145_splice|SFTPC_uc003xay.3_Splice_Site_p.Q145_splice|BMP1_uc011kzb.1_5'Flank|BMP1_uc003xba.2_5'Flank|BMP1_uc003xbb.2_5'Flank|BMP1_uc003xbe.2_5'Flank|BMP1_uc003xbc.2_5'Flank|BMP1_uc003xbd.2_5'Flank|BMP1_uc003xbf.2_5'Flank|BMP1_uc003xbg.2_5'Flank|BMP1_uc011kzc.1_5'Flank|BMP1_uc003xbh.2_5'Flank|BMP1_uc003xbi.2_5'Flank	NM_003018	NP_003009	P11686	PSPC_HUMAN	surfactant protein C precursor						respiratory gaseous exchange	extracellular space					0				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CAACTTCCAGGTGTGTGTGTGT	0.545		NA											7	55	---	---	---	---	NA	NA	NA	NA
COL14A1	7373	broad.mit.edu	37	8	121180418	121180418	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BA-5152-01A-02D-1870-08	TCGA-BA-5152-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	18da68fd-3bfb-45a3-ba28-4c90555b4e68	83d66369-f76e-42bf-b953-24b4f2b2d2e9	g.chr8:121180418delG	uc003yox.2	+	5	633	c.368delG	c.(367-369)AGAfs	p.R123fs		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	123					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTAGAAAAAAGAAAGGATCCA	0.353		NA											69	124	---	---	---	---	NA	NA	NA	NA