Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ASAP3	55616	broad.mit.edu	37	1	23759729	23759729	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:23759729C>T	uc001bha.2	-	22	2288	c.2164G>A	c.(2164-2166)GCC>ACC	p.A722T	ASAP3_uc001bgy.1_Missense_Mutation_p.A226T|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Missense_Mutation_p.A612T|ASAP3_uc010oea.1_Missense_Mutation_p.A713T|ASAP3_uc001bhb.2_Missense_Mutation_p.A245T	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	722					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CTCCCACTGGCCCAGTGAGCC	0.642		NA											39	148					0	0	0	0
ASAP3	55616	broad.mit.edu	37	1	23763755	23763755	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:23763755C>T	uc001bha.2	-	14	1334	c.1210G>A	c.(1210-1212)GAG>AAG	p.E404K	ASAP3_uc001bgy.1_5'Flank|ASAP3_uc001bgz.1_5'Flank|ASAP3_uc010odz.1_Missense_Mutation_p.E273K|ASAP3_uc010oea.1_Missense_Mutation_p.E395K|ASAP3_uc001bhb.2_5'UTR	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	404					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						GCGCTGGGCTCCCCGAGGAAG	0.662		NA											5	15					0	0	0	0
HECTD3	79654	broad.mit.edu	37	1	45475780	45475780	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:45475780T>C	uc009vxk.2	-	4	735	c.637A>G	c.(637-639)ACA>GCA	p.T213A	HECTD3_uc001cmy.3_5'Flank|HECTD3_uc010olh.1_Intron|UROD_uc010oli.1_5'Flank|UROD_uc001cna.1_5'Flank|UROD_uc001cnb.1_5'Flank|UROD_uc010olj.1_5'Flank|UROD_uc001cnc.1_5'Flank	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	213					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					TAGGTCCATGTCGGGGGTACA	0.567		NA											21	85					0	0	0	0
CCDC17	149483	broad.mit.edu	37	1	46087966	46087966	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:46087966C>T	uc010olt.1	-	7	1062	c.914G>A	c.(913-915)CGC>CAC	p.R305H	CCDC17_uc009vxy.2_Missense_Mutation_p.R273H|CCDC17_uc010ols.1_Missense_Mutation_p.R296H|CCDC17_uc001com.3_Missense_Mutation_p.R126H|CCDC17_uc001con.3_RNA|CCDC17_uc009vxz.2_Intron	NM_001114938	NP_001108410	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	305	Potential.									ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGCCTCCAAGCGCCGGTTTTC	0.582		NA											10	25					0	0	0	0
RBM15	64783	broad.mit.edu	37	1	110882129	110882129	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:110882129C>T	uc001dzl.1	+	1	185	c.102C>T	c.(100-102)CTC>CTT	p.L34L	RBM15_uc001dzm.1_Silent_p.L34L|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	34					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TTACTCAGCTCCGCGGAGACG	0.677		NA	T	MKL1	acute megakaryocytic leukemia								14	36					0	0	0	0
MAGI3	260425	broad.mit.edu	37	1	114092242	114092242	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:114092242G>A	uc001edk.2	+	2	603	c.422G>A	c.(421-423)AGA>AAA	p.R141K	MAGI3_uc001edh.3_Missense_Mutation_p.R141K|MAGI3_uc001edi.3_Missense_Mutation_p.R141K|MAGI3_uc010owm.1_Missense_Mutation_p.R141K	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	141	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTCTACTTGAGAACCATTCCA	0.338		NA											4	78					0	0	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145473666	145473666	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:145473666C>G	uc001enq.1	+	4	1631	c.338C>G	c.(337-339)TCG>TGG	p.S113W	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	113	ANK 4.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCGGGCGCCTCGGCTCTTGTC	0.711		NA											15	42					0	0	0	0
CRNN	49860	broad.mit.edu	37	1	152382225	152382225	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:152382225C>T	uc001ezx.2	-	3	1407	c.1333G>A	c.(1333-1335)GAC>AAC	p.D445N		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	445					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGAGTGGTCATCAACCCAT	0.577		NA											25	87					0	0	0	0
CD1A	909	broad.mit.edu	37	1	158226066	158226066	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:158226066C>T	uc001frt.2	+	3	1131	c.598C>T	c.(598-600)CGG>TGG	p.R200W		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	200	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	ACATCTCCAGCGGCAAGGTCA	0.463		NA											8	123					0	0	0	0
FCRLB	127943	broad.mit.edu	37	1	161692465	161692465	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:161692465G>A	uc001gbh.2	+	3	237	c.3G>A	c.(1-3)ATG>ATA	p.M1I	FCRLB_uc009wus.2_Missense_Mutation_p.M1I|FCRLB_uc001gbj.2_Missense_Mutation_p.M1I|FCRLB_uc001gbk.2_Missense_Mutation_p.M1I|FCRLB_uc001gbl.2_Missense_Mutation_p.M1I|FCRLB_uc001gbm.2_Missense_Mutation_p.M1I|FCRLB_uc001gbi.2_Missense_Mutation_p.M1I	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	1						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GATCCATCATGTGGCCACTGA	0.557		NA											84	250					0	0	0	0
KIF21B	23046	broad.mit.edu	37	1	200950187	200950187	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:200950187G>A	uc001gvs.1	-	29	4197	c.3880C>T	c.(3880-3882)CGG>TGG	p.R1294W	KIF21B_uc001gvr.1_Missense_Mutation_p.R1281W|KIF21B_uc009wzl.1_Missense_Mutation_p.R1294W|KIF21B_uc010ppn.1_Missense_Mutation_p.R1281W	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1294					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGGGCCGTCCGTGCACCCTTG	0.622		NA											52	64					0	0	0	0
GPATCH2	55105	broad.mit.edu	37	1	217665079	217665079	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:217665079C>T	uc001hlf.1	-	8	1316	c.1220G>A	c.(1219-1221)AGA>AAA	p.R407K	GPATCH2_uc009xdq.1_RNA	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	407						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		TCGATTATCTCTCAGAAGCTG	0.313		NA											16	84					0	0	0	0
PCNXL2	80003	broad.mit.edu	37	1	233270852	233270852	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:233270852C>T	uc001hvl.2	-	21	3979	c.3744G>A	c.(3742-3744)TTG>TTA	p.L1248L	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1248	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGTGAAGCTCAAGTTAATAA	0.398		NA											13	50					0	0	0	0
RYR2	6262	broad.mit.edu	37	1	237895442	237895442	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr1:237895442G>A	uc001hyl.1	+	78	11152	c.11032G>A	c.(11032-11034)GAG>AAG	p.E3678K	RYR2_uc010pya.1_Missense_Mutation_p.E74K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3678					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCTTTAACAGAGAAATGGTA	0.453		NA											11	74					0	0	0	0
OIT3	170392	broad.mit.edu	37	10	74673159	74673159	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr10:74673159G>A	uc001jte.1	+	6	1102	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	295	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					ACCTCCTGCCGAGGAGTGTCC	0.542		NA											62	149					0	0	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116057015	116057015	+	Silent	SNP	G	G	A	rs150853765	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr10:116057015G>A	uc001lbn.2	-	17	2572	c.2271C>T	c.(2269-2271)ACC>ACT	p.T757T	AFAP1L2_uc001lbo.2_Silent_p.T757T|AFAP1L2_uc010qse.1_Silent_p.T810T|AFAP1L2_uc001lbp.2_Silent_p.T785T|AFAP1L2_uc001lbm.2_Silent_p.T196T|AFAP1L2_uc010qsd.1_Silent_p.T323T|AFAP1L2_uc001lbq.1_Silent_p.T279T	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	757					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TGGTGTCCACGGTGGTGCCTA	0.652		NA											18	52					0	0	0	0
ABCC8	6833	broad.mit.edu	37	11	17426127	17426127	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:17426127G>A	uc001mnc.2	-	28	3615	c.3489C>T	c.(3487-3489)TTC>TTT	p.F1163F		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1163	Helical; Name=15; (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GGGCCACGAGGAACACAGGTG	0.627		NA											17	96					0	0	0	0
ASRGL1	80150	broad.mit.edu	37	11	62159699	62159699	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:62159699C>T	uc001nte.3	+	7	1154	c.870C>T	c.(868-870)GAC>GAT	p.D290D	ASRGL1_uc001ntf.3_Silent_p.D290D|ASRGL1_uc001ntg.3_Silent_p.D162D	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	290					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	CCGCCAAGGACGGCAAGCTGC	0.532		NA									OREG0021023	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	79	84					0	0	0	0
PLCB3	5331	broad.mit.edu	37	11	64033385	64033385	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:64033385G>A	uc001nzb.2	+	26	3063	c.3063G>A	c.(3061-3063)ACG>ACA	p.T1021T	PLCB3_uc009ypg.1_Silent_p.T1021T|PLCB3_uc009yph.1_Silent_p.T954T|PLCB3_uc009ypi.2_Silent_p.T1021T	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1021					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						TGGAGGACACGAAGGAGGGGG	0.662		NA											21	29					0	0	0	0
CTTN	2017	broad.mit.edu	37	11	70260656	70260656	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:70260656C>T	uc001opv.3	+	6	506	c.300C>T	c.(298-300)GTC>GTT	p.V100V	CTTN_uc001opu.2_Silent_p.V100V|CTTN_uc001opw.3_Silent_p.V100V	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	100	Cortactin 1.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		AGTCAGCTGTCGGCCACGAAT	0.557		NA											17	89					0	0	0	0
PDE2A	5138	broad.mit.edu	37	11	72292993	72292993	+	Splice_Site	SNP	T	T	C			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:72292993T>C	uc010rrc.1	-	22	2095	c.1852_splice	c.e22-1	p.A618_splice	PDE2A_uc001oso.2_Splice_Site_p.A597_splice|PDE2A_uc010rra.1_Splice_Site_p.A611_splice|PDE2A_uc001osn.2_Splice_Site_p.A362_splice|PDE2A_uc010rrb.1_Splice_Site_p.A609_splice|PDE2A_uc010rrd.1_Splice_Site_p.A503_splice	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1						platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CAGGATGGCCTGGAGAGGGCA	0.567		NA											3	65					0	0	0	0
DLAT	1737	broad.mit.edu	37	11	111916646	111916646	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr11:111916646C>T	uc001pmo.2	+	10	2009	c.1350C>T	c.(1348-1350)ATC>ATT	p.I450I	DLAT_uc009yyk.1_Silent_p.I345I|DLAT_uc010rwr.1_Silent_p.I323I	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	450	Catalytic (By similarity).				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	ACCTTTCTATCGATGTAAATA	0.299		NA											10	54					0	0	0	0
IFFO1	25900	broad.mit.edu	37	12	6665033	6665033	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:6665033C>T	uc001qpd.1	-	1	197	c.163G>A	c.(163-165)GGG>AGG	p.G55R	IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Missense_Mutation_p.G55R|IFFO1_uc001qpf.1_Missense_Mutation_p.G55R|IFFO1_uc001qpc.1_Missense_Mutation_p.G55R	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	55						intermediate filament					0						gggcccggcccgggcggcgAG	0.587		NA											4	64					0	0	0	0
LRP6	4040	broad.mit.edu	37	12	12315147	12315147	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:12315147G>A	uc001rah.3	-	10	2401	c.2259C>T	c.(2257-2259)CTC>CTT	p.L753L	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Silent_p.L753L	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	753	Extracellular (Potential).|Beta-propeller 3.|LDL-receptor class B 12.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GGTCCAACGCGAGAGCTCTGG	0.478		NA											13	199					0	0	0	0
SLC6A15	55117	broad.mit.edu	37	12	85266897	85266897	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:85266897C>T	uc001szv.2	-	7	1571	c.1078G>A	c.(1078-1080)GCA>ACA	p.A360T	SLC6A15_uc010sul.1_Missense_Mutation_p.A253T|SLC6A15_uc001szw.1_Missense_Mutation_p.A68T	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	360	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						ATGACATTTGCTTTGAAGCCC	0.333		NA											13	72					0	0	0	0
ANO4	121601	broad.mit.edu	37	12	101480443	101480443	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:101480443C>T	uc010svm.1	+	17	2114	c.1542C>T	c.(1540-1542)TGC>TGT	p.C514C	ANO4_uc001thw.2_Silent_p.C479C|ANO4_uc001thx.2_Silent_p.C514C|ANO4_uc001thy.2_Silent_p.C34C	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	514	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GCCAGATCTGCGTGGTGATTG	0.507		NA								HNSCC(74;0.22)			9	672					0	0	0	0
TXNRD1	7296	broad.mit.edu	37	12	104719127	104719127	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr12:104719127G>A	uc010swk.1	+	11	1250	c.1228G>A	c.(1228-1230)GAA>AAA	p.E410K	TXNRD1_uc010swl.1_Missense_Mutation_p.E260K|TXNRD1_uc010swm.1_Missense_Mutation_p.E312K|TXNRD1_uc010swn.1_Missense_Mutation_p.E260K|TXNRD1_uc010swo.1_Missense_Mutation_p.E260K|TXNRD1_uc010swp.1_Missense_Mutation_p.E222K|TXNRD1_uc010swq.1_Missense_Mutation_p.E310K|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.E326K	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	410					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TGAACAAATTGAAGCAGGGAC	0.418		NA											5	23					0	0	0	0
TBPL2	387332	broad.mit.edu	37	14	55903726	55903726	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr14:55903726G>A	uc001xby.2	-	2	161	c.161C>T	c.(160-162)GCC>GTC	p.A54V		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	54					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						CCTGGGTGGGGCAAGGCCATC	0.483		NA											4	202					0	0	0	0
MTMR10	54893	broad.mit.edu	37	15	31234209	31234209	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr15:31234209C>T	uc001zfh.1	-	16	1896	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K	MTMR15_uc001zff.2_3'UTR|MTMR15_uc001zfe.2_3'UTR|MTMR10_uc010ubk.1_Missense_Mutation_p.E14K|MTMR10_uc001zfg.1_Missense_Mutation_p.E181K|MTMR10_uc010azx.1_Missense_Mutation_p.E352K|MTMR10_uc001zfi.1_3'UTR	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	600	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		GGAAGTAATTCTTGGTCACTG	0.408		NA											9	320					0	0	0	0
MFGE8	4240	broad.mit.edu	37	15	89450552	89450552	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr15:89450552G>A	uc002bng.3	-	3	374	c.261C>T	c.(259-261)GCC>GCT	p.A87A	MFGE8_uc002bnf.3_5'UTR|MFGE8_uc002bnh.3_Silent_p.A87A|MFGE8_uc010bnn.2_Silent_p.A79A|MFGE8_uc010upq.1_Silent_p.A43A|MFGE8_uc010upr.1_Silent_p.A87A|MFGE8_uc010bno.2_Silent_p.A43A	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	87	F5/8 type C 1.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					CAGACGAGGCGGCGATCTGTG	0.617		NA											23	38					0	0	0	0
PPL	5493	broad.mit.edu	37	16	4947769	4947769	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr16:4947769C>T	uc002cyd.1	-	9	969	c.879G>A	c.(877-879)GCG>GCA	p.A293A		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	293	Potential.|Spectrin 1.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CCTCCATGTGCGCCTGCCAGG	0.612		NA											3	28					0	0	0	0
BCKDK	10295	broad.mit.edu	37	16	31122691	31122691	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr16:31122691G>A	uc002eaw.3	+	10	1232	c.916G>A	c.(916-918)GAT>AAT	p.D306N	BCKDK_uc002eav.3_Missense_Mutation_p.D306N|BCKDK_uc010cah.2_RNA|BCKDK_uc010cai.2_Intron	NM_005881	NP_005872	O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	306	Histidine kinase.				branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			stomach(1)|breast(1)	2						CGCCAACAATGATGTCGATCT	0.507		NA											17	68					0	0	0	0
KIAA0664	23277	broad.mit.edu	37	17	2604101	2604101	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:2604101G>A	uc002fuy.1	-	8	1016	c.930C>T	c.(928-930)TTC>TTT	p.F310F	KIAA0664_uc002fux.1_Silent_p.F242F	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	310							binding			breast(2)	2						CGATCCTCTCGAACGGGTGGC	0.682		NA											16	42					0	0	0	0
MYH3	4621	broad.mit.edu	37	17	10558189	10558189	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:10558189C>T	uc002gmq.1	-	2	270	c.193G>A	c.(193-195)GAG>AAG	p.E65K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	65	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTGTTGTCCTCAGTTTCCACA	0.537		NA											84	300					0	0	0	0
AKAP10	11216	broad.mit.edu	37	17	19835244	19835244	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:19835244C>T	uc002gwo.2	-	10	1652	c.1515G>A	c.(1513-1515)TTG>TTA	p.L505L	AKAP10_uc002gwp.1_Silent_p.L505L|AKAP10_uc010cqw.1_Intron	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	505	RGS 2.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					TGAGATCATTCAAATATTTAT	0.418		NA											15	107					0	0	0	0
FOXN1	8456	broad.mit.edu	37	17	26851658	26851658	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:26851658C>T	uc010crm.2	+	3	459	c.261C>T	c.(259-261)GGC>GGT	p.G87G	FOXN1_uc002hbj.2_Silent_p.G87G	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	87					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CCGGCCCCGGCCCTGGGCCCT	0.682		NA											18	93					0	0	0	0
GPR179	440435	broad.mit.edu	37	17	36491542	36491542	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:36491542G>A	uc002hpz.2	-	6	1359	c.1338C>T	c.(1336-1338)ATC>ATT	p.I446I		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	446	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCGAAGAGCGATGCAGCGGA	0.443		NA											15	63					0	0	0	0
GSDMA	284110	broad.mit.edu	37	17	38133088	38133088	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:38133088A>G	uc002htl.1	+	12	1233	c.1115A>G	c.(1114-1116)CAG>CGG	p.Q372R	GSDMA_uc002htm.1_Missense_Mutation_p.Q372R	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	372					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						ACGATGGAACAGAACTTCCTG	0.517		NA											30	183					0	0	0	0
KRT39	390792	broad.mit.edu	37	17	39122694	39122694	+	Silent	SNP	G	G	A	rs144576097	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:39122694G>A	uc002hvo.1	-	1	451	c.415C>T	c.(415-417)CTA>TTA	p.L139L	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	139	Linker 1.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				TCAGGACATAGAACAGGGAGC	0.423		NA											55	189					0	0	0	0
C17orf57	124989	broad.mit.edu	37	17	45473259	45473259	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:45473259G>A	uc002iln.2	+	17	2272	c.1861G>A	c.(1861-1863)GAC>AAC	p.D621N	C17orf57_uc002ilm.2_Missense_Mutation_p.D525N	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	621							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GAGTGTTTCTGACCTGTGGAA	0.373		NA											27	112					0	0	0	0
ABCA10	10349	broad.mit.edu	37	17	67186544	67186544	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:67186544C>A	uc010dfa.1	-	19	2965	c.2086G>T	c.(2086-2088)GAA>TAA	p.E696*	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Nonsense_Mutation_p.E297*	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	696					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					AAGAATACTTCATTCAGAGAT	0.333		NA											19	98					3.52e-12	3.88e-12	1	0
KCNJ16	3773	broad.mit.edu	37	17	68129405	68129405	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:68129405G>A	uc002jin.2	+	5	1663	c.1177G>A	c.(1177-1179)GCC>ACC	p.A393T	KCNJ16_uc002jio.2_Missense_Mutation_p.A393T|KCNJ16_uc002jip.2_Missense_Mutation_p.A393T|KCNJ16_uc002jiq.2_Missense_Mutation_p.A425T	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	393	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CACCACTTCCGCCACACATGA	0.458		NA											23	107					0	0	0	0
FDXR	2232	broad.mit.edu	37	17	72862630	72862630	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:72862630C>T	uc002jly.2	-	4	418	c.331G>A	c.(331-333)GTG>ATG	p.V111M	FDXR_uc010wri.1_Missense_Mutation_p.V59M|FDXR_uc010wrj.1_Missense_Mutation_p.V109M|FDXR_uc002jlw.2_Translation_Start_Site|FDXR_uc002jlx.2_Missense_Mutation_p.V111M|FDXR_uc002jmc.2_Missense_Mutation_p.V112M|FDXR_uc010wrk.1_Missense_Mutation_p.V142M|FDXR_uc010wrl.1_Missense_Mutation_p.V154M|FDXR_uc002jma.2_Missense_Mutation_p.V112M|FDXR_uc010wrm.1_Intron|FDXR_uc002jlz.2_Missense_Mutation_p.V103M|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	111					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CCCACCTCCACGTTGCCCCAG	0.652		NA											18	44					0	0	0	0
PGS1	9489	broad.mit.edu	37	17	76388715	76388715	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr17:76388715C>T	uc002jvm.2	+	2	314	c.302C>T	c.(301-303)TCT>TTT	p.S101F	PGS1_uc010wtt.1_RNA	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	101					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			AGGGTGCTTTCTTCCCCGGCA	0.502		NA											27	141					0	0	0	0
MAPK4	5596	broad.mit.edu	37	18	48190638	48190638	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr18:48190638G>A	uc002lev.2	+	2	1310	c.310G>A	c.(310-312)GTC>ATC	p.V104I	MAPK4_uc010xdm.1_Intron|MAPK4_uc010doz.2_Missense_Mutation_p.V104I	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	104	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GGCGTACATCGTCCAGGAGTA	0.612		NA											26	105					0	0	0	0
SALL3	27164	broad.mit.edu	37	18	76753935	76753935	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr18:76753935G>A	uc002lmt.2	+	2	1944	c.1944G>A	c.(1942-1944)CCG>CCA	p.P648P	SALL3_uc010dra.2_Silent_p.P255P	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	648					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCCAGTTTCCGTTCGGGGGGC	0.652		NA											3	15					0	0	0	0
NFATC1	4772	broad.mit.edu	37	18	77246917	77246917	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr18:77246917A>G	uc010xfg.1	+	9	3215	c.2762A>G	c.(2761-2763)GAC>GGC	p.D921G	NFATC1_uc002lnd.2_Intron|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Missense_Mutation_p.D449G|NFATC1_uc002lnf.2_Missense_Mutation_p.D908G|NFATC1_uc002lng.2_Intron|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	921	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GAAGAGTTGGACCAGTTGTAC	0.637		NA											3	122					0	0	0	0
ABCA7	10347	broad.mit.edu	37	19	1058700	1058700	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:1058700C>T	uc002lqw.3	+	38	5464	c.5233C>T	c.(5233-5235)CTT>TTT	p.L1745F	ABCA7_uc002lqy.2_Missense_Mutation_p.L198F|ABCA7_uc010dsc.2_RNA	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1745	Helical; (Potential).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCCTCTTCCTTCTCTTCAC	0.572		NA											31	189					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9065980	9065980	+	Missense_Mutation	SNP	T	T	C			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:9065980T>C	uc002mkp.2	-	3	21670	c.21466A>G	c.(21466-21468)AGC>GGC	p.S7156G		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7158	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGTGTGGCTCAGCTTTGGA	0.502		NA											32	139					0	0	0	0
C19orf66	55337	broad.mit.edu	37	19	10202783	10202783	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:10202783G>A	uc002mmu.3	+	8	979	c.681G>A	c.(679-681)AAG>AAA	p.K227K	C19orf66_uc002mmv.3_Silent_p.K191K|C19orf66_uc002mmw.3_Silent_p.K176K	NM_018381	NP_060851	Q9NUL5	CS066_HUMAN	hypothetical protein LOC55337	227											0						CTCACCCCAAGAGCCGGAAGC	0.642		NA											29	139					0	0	0	0
CILP2	148113	broad.mit.edu	37	19	19654523	19654523	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:19654523G>A	uc002nmv.3	+	8	1254	c.1169G>A	c.(1168-1170)CGA>CAA	p.R390Q	CILP2_uc002nmw.3_Missense_Mutation_p.R396Q	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	390						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CCCCGGCCCCGAGAGTACCTG	0.662		NA											125	491					0	0	0	0
DHX34	9704	broad.mit.edu	37	19	47856613	47856613	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:47856613C>T	uc010xyn.1	+	2	667	c.326C>T	c.(325-327)TCT>TTT	p.S109F	DHX34_uc010elc.1_Missense_Mutation_p.S109F	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	109						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		ATCAACCTCTCTGTTCTTGGC	0.637		NA											52	282					0	0	0	0
VRK3	51231	broad.mit.edu	37	19	50482394	50482394	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:50482394C>T	uc002prg.2	-	14	1480	c.1382G>A	c.(1381-1383)CGT>CAT	p.R461H	VRK3_uc002prh.1_Missense_Mutation_p.R461H|VRK3_uc002pri.1_Missense_Mutation_p.R411H|VRK3_uc010ens.2_Missense_Mutation_p.R461H|VRK3_uc010ybl.1_Missense_Mutation_p.R411H|VRK3_uc010ybm.1_Missense_Mutation_p.R230H	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	461						nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		TGGAGACACACGCAGATCCTG	0.572		NA											53	113					0	0	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:58385546G>T	uc002qqo.2	-	3	1484	c.1212C>A	c.(1210-1212)GAC>GAA	p.D404E	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AATGTTTTTTGTCAGTGTGAA	0.393		NA											5	19					1.24e-05	1.33e-05	1	0
ACOXL	55289	broad.mit.edu	37	2	111666365	111666365	+	Splice_Site	SNP	G	G	A	rs2974746		TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:111666365G>A	uc002tgr.3	+	11	1013	c.789_splice	c.e11-1	p.S263_splice	ACOXL_uc010fkc.2_Splice_Site_p.S263_splice|ACOXL_uc010yxk.1_Splice_Site_p.S263_splice	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2						fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						ATTCCCTCTAGCCGGAGGCAG	0.522		NA											23	79					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167162315	167162315	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:167162315C>T	uc010fpl.2	-	5	924	c.583G>A	c.(583-585)GTC>ATC	p.V195I	SCN9A_uc002udr.1_Missense_Mutation_p.V66I|SCN9A_uc002uds.1_Missense_Mutation_p.V66I|SCN9A_uc002udt.1_Missense_Mutation_p.V66I	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	195	Helical; Name=S3 of repeat I; (Potential).|I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.V195I(1)		ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	AAAACAATGACGACAAAATCC	0.398		NA											13	44					0	0	0	0
HOXD3	3232	broad.mit.edu	37	2	177033995	177033995	+	Silent	SNP	A	A	C	rs141168805	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:177033995A>C	uc002ukt.1	+	2	329	c.153A>C	c.(151-153)CCA>CCC	p.P51P		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	51					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGCCCTACCCACCCCCTGCTG	0.587		NA											8	101					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179582457	179582457	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:179582457G>A	uc010zfg.1	-	84	21636	c.21412C>T	c.(21412-21414)CGC>TGC	p.R7138C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R3799C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8065							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATTGATGCGGCATTCAAAT	0.413		NA											6	46					0	0	0	0
ATG16L1	55054	broad.mit.edu	37	2	234171780	234171780	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr2:234171780G>A	uc002vty.2	+	3	471	c.214G>A	c.(214-216)GGA>AGA	p.G72R	ATG16L1_uc002vtx.1_Intron|ATG16L1_uc002vua.2_Missense_Mutation_p.G72R|ATG16L1_uc002vub.2_5'UTR|ATG16L1_uc002vtz.2_Intron|ATG16L1_uc002vud.3_5'UTR	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	72					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		ATTTAGTCCCGGACATGATGG	0.438		NA											7	31					0	0	0	0
SNRPB	6628	broad.mit.edu	37	20	2443804	2443804	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr20:2443804C>A	uc002wfz.1	-	5	653	c.490G>T	c.(490-492)GCT>TCT	p.A164S	SNRPB_uc002wga.1_Missense_Mutation_p.A164S|SNRPB_uc010zpv.1_Missense_Mutation_p.A85S|SNRPB_uc002wgb.2_Missense_Mutation_p.A164S|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	164					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						TGGGTTGGAGCCCCGGCAATA	0.592		NA											66	154					1.6e-33	1.77e-33	1	0
RPN2	6185	broad.mit.edu	37	20	35827572	35827572	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr20:35827572C>T	uc002xgp.2	+	4	727	c.423C>T	c.(421-423)TCC>TCT	p.S141S	RPN2_uc002xgo.3_Silent_p.S141S|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Silent_p.S109S	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	141	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CCTTGGCATCCCAAGAAGCAC	0.527		NA											11	254					0	0	0	0
GNAS	2778	broad.mit.edu	37	20	57428501	57428501	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr20:57428501G>A	uc002xzw.2	+	1	466	c.181G>A	c.(181-183)GTC>ATC	p.V61I	GNASAS_uc002xzs.1_5'Flank|GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCCCATCCCCGTCGAGAATGA	0.642		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			10	39					0	0	0	0
SIK1	150094	broad.mit.edu	37	21	44841623	44841623	+	Missense_Mutation	SNP	G	G	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr21:44841623G>T	uc002zdf.2	-	5	521	c.394C>A	c.(394-396)CAA>AAA	p.Q132K		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	132	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						GACAGGATTTGCCAGAACTTC	0.552		NA											15	36					2.32e-09	2.55e-09	1	0
GRAMD4	23151	broad.mit.edu	37	22	47062766	47062766	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr22:47062766C>G	uc003bhx.2	+	9	893	c.854C>G	c.(853-855)CCC>CGC	p.P285R	GRAMD4_uc010had.2_Missense_Mutation_p.P224R	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	285					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		GTGTCTGAGCCCGTGGTAAGT	0.617		NA											3	151					0	0	0	0
ACR	49	broad.mit.edu	37	22	51183225	51183225	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr22:51183225G>A	uc003bnh.3	+	5	868	c.856G>A	c.(856-858)GCC>ACC	p.A286T		NM_001097	NP_001088	P10323	ACRO_HUMAN	acrosin precursor	286	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		GAACTGGATCGCCTCCAAGAT	0.622		NA											9	12					0	0	0	0
SCN5A	6331	broad.mit.edu	37	3	38647495	38647495	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:38647495C>T	uc003cio.2	-	10	1479	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K	SCN5A_uc003cin.2_Missense_Mutation_p.E429K|SCN5A_uc003cil.3_Missense_Mutation_p.E429K|SCN5A_uc010hhi.2_Missense_Mutation_p.E429K|SCN5A_uc010hhk.2_Missense_Mutation_p.E429K|SCN5A_uc011ayr.1_Missense_Mutation_p.E429K|SCN5A_uc010hhj.1_Missense_Mutation_p.E40K	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	429					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTTTCCTTCTCCTCGGTCTCA	0.567		NA											4	143					0	0	0	0
RHO	6010	broad.mit.edu	37	3	129251103	129251103	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:129251103C>T	uc003emt.2	+	3	635	c.540C>T	c.(538-540)CCC>CCT	p.P180P		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	180	Extracellular.				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	GGTACATCCCCGAGGGCCTGC	0.587		NA											14	90					0	0	0	0
GHSR	2693	broad.mit.edu	37	3	172165615	172165615	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:172165615C>T	uc003fib.1	-	1	589	c.589G>A	c.(589-591)GAG>AAG	p.E197K	GHSR_uc011bpv.1_Missense_Mutation_p.E197K	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	197	Extracellular (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GGGCGGCACTCGTTGGTGTCC	0.622		NA											17	76					0	0	0	0
WDR53	348793	broad.mit.edu	37	3	196288329	196288329	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr3:196288329C>T	uc003fwt.2	-	3	489	c.18G>A	c.(16-18)ACG>ACA	p.T6T		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	6										breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		AATGCCCACCCGTCCACTTGA	0.522		NA											15	89					0	0	0	0
BMP2K	55589	broad.mit.edu	37	4	79792071	79792071	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr4:79792071C>T	uc003hlk.2	+	11	1532	c.1366C>T	c.(1366-1368)CGT>TGT	p.R456C	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.R456C|BMP2K_uc003hll.2_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	456	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						TTTACAGCATCGTCATCCTCA	0.294		NA											4	35					0	0	0	0
FRG1	2483	broad.mit.edu	37	4	190878594	190878594	+	Missense_Mutation	SNP	A	A	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr4:190878594A>T	uc003izs.2	+	6	665	c.474A>T	c.(472-474)AGA>AGT	p.R158S		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	158					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GCTTTATTAGATGCAATGAAG	0.368		NA											4	46					0	0	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41008798	41008798	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:41008798G>A	uc003jmj.3	-	33	4008	c.3518C>T	c.(3517-3519)ACA>ATA	p.T1173I	HEATR7B2_uc003jmi.3_Missense_Mutation_p.T728I	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1173	HEAT 13.						binding			ovary(6)|central_nervous_system(2)	8						CTGGCCCAGTGTGCAGCTAAC	0.567		NA											25	55					0	0	0	0
PRR16	51334	broad.mit.edu	37	5	120021719	120021719	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:120021719C>T	uc003ksq.2	+	2	393	c.230C>T	c.(229-231)ACG>ATG	p.T77M	PRR16_uc003ksp.2_Missense_Mutation_p.T54M|PRR16_uc003ksr.2_Missense_Mutation_p.T7M	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	77										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		AGCTCCAAAACGGACACGCTG	0.502		NA											30	85					0	0	0	0
PCDHA11	56138	broad.mit.edu	37	5	140248820	140248820	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140248820C>T	uc003lia.2	+	1	990	c.132C>T	c.(130-132)TTC>TTT	p.F44F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.F44F	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	44	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGCACCTTCGTGGGCCGCA	0.652		NA											47	138					0	0	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347507	140347507	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140347507G>A	uc003lii.2	+	1	1396	c.1156G>A	c.(1156-1158)GTT>ATT	p.V386I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.V386I	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	386	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTGTGGCCGTTCTCAGTGT	0.557		NA											4	139					0	0	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595079	140595079	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140595079G>A	uc003lja.1	+	1	1571	c.1384G>A	c.(1384-1386)GAG>AAG	p.E462K		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	462	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGTCCGCGAGAACAACAG	0.602		NA											27	186					0	0	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731948	140731948	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr5:140731948C>T	uc003ljo.1	+	1	2121	c.2121C>T	c.(2119-2121)ATC>ATT	p.I707I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Silent_p.I707I|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	707	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTAGCGATCGCCCTGCGCC	0.617		NA											61	214					0	0	0	0
BTNL2	56244	broad.mit.edu	37	6	32372831	32372831	+	Missense_Mutation	SNP	C	C	G			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:32372831C>G	uc003obg.1	-	2	312	c.312G>C	c.(310-312)AAG>AAC	p.K104N	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	104	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CCACATTTCCCTTTGCAATGC	0.507		NA											55	95					0	0	0	0
FUCA2	2519	broad.mit.edu	37	6	143825112	143825112	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:143825112G>A	uc003qjm.2	-	3	782	c.690C>T	c.(688-690)GAC>GAT	p.D230D	FUCA2_uc003qjn.2_5'Flank	NM_032020	NP_114409	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma precursor	230					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		GTGCTCCTCCGTCACCATCCG	0.463		NA											15	35					0	0	0	0
UTRN	7402	broad.mit.edu	37	6	145069596	145069596	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:145069596G>A	uc003qkt.2	+	54	8246	c.8154G>A	c.(8152-8154)AAG>AAA	p.K2718K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2718	Spectrin 20.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATGGCTGGAAGCCCGTGGGAG	0.473		NA											3	60					0	0	0	0
THBS2	7058	broad.mit.edu	37	6	169648954	169648954	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr6:169648954C>T	uc003qwt.2	-	4	415	c.167G>A	c.(166-168)CGC>CAC	p.R56H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	56	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GCGCACGAAGCGGTAAGCCGG	0.587		NA											14	31					0	0	0	0
FBXL18	80028	broad.mit.edu	37	7	5521496	5521496	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr7:5521496G>A	uc003son.3	-	5	2161	c.2067C>T	c.(2065-2067)GAC>GAT	p.D689D		NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	Error:Variant_position_missing_in_Q96ME1_after_alignment										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CCCGGATGACGTCGGTCAGGC	0.617		NA											64	161					0	0	0	0
CROT	54677	broad.mit.edu	37	7	87027901	87027901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr7:87027901C>T	uc003uit.2	+	18	2025	c.1780C>T	c.(1780-1782)CAG>TAG	p.Q594*	CROT_uc003uiu.2_Nonsense_Mutation_p.Q622*	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	594					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	AAAGCTAGTTCAGCTGACTTT	0.373		NA											20	70					0	0	0	0
ARF5	381	broad.mit.edu	37	7	127231136	127231136	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr7:127231136C>T	uc003vmb.1	+	5	486	c.450C>T	c.(448-450)AGC>AGT	p.S150S	FSCN3_uc003vmc.1_5'Flank|FSCN3_uc011kog.1_5'Flank|FSCN3_uc011koh.1_5'Flank|FSCN3_uc003vmd.1_5'Flank|FSCN3_uc010llc.1_5'Flank	NM_001662	NP_001653	P84085	ARF5_HUMAN	ADP-ribosylation factor 5	150					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1						ACTTACGCAGCCGCACGGTAG	0.577		NA											13	192					0	0	0	0
DOCK5	80005	broad.mit.edu	37	8	25159858	25159858	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:25159858C>T	uc003xeg.2	+	10	1001	c.864C>T	c.(862-864)GAC>GAT	p.D288D	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Silent_p.D2D|DOCK5_uc003xef.2_Silent_p.D288D	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	288						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GCAGCATGGACCTCATCCGGC	0.557		NA											24	27					0	0	0	0
EPHX2	2053	broad.mit.edu	37	8	27398085	27398085	+	Missense_Mutation	SNP	A	A	G			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:27398085A>G	uc003xfu.2	+	15	1372	c.1291A>G	c.(1291-1293)AAT>GAT	p.N431D	EPHX2_uc010luu.2_Missense_Mutation_p.N399D|EPHX2_uc010luv.2_Missense_Mutation_p.N365D|EPHX2_uc003xfv.2_Missense_Mutation_p.N378D|EPHX2_uc010luw.2_Missense_Mutation_p.N365D	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	431	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	ACTTTTTGTAAATAGCCCAGA	0.502		NA											43	91					0	0	0	0
PAG1	55824	broad.mit.edu	37	8	81897445	81897445	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:81897445C>T	uc003ybz.2	-	7	1153	c.442G>A	c.(442-444)GCG>ACG	p.A148T		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	148	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			ACACTTCTCGCCGTGAGCATG	0.577		NA											14	129					0	0	0	0
FBXO43	286151	broad.mit.edu	37	8	101153320	101153320	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:101153320G>A	uc003yjd.2	-	2	1875	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	FBXO43_uc003yje.2_Missense_Mutation_p.R354W|FBXO43_uc010mbp.1_Missense_Mutation_p.R388W	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	388					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			CTTTGTTCCCGAAGGGTGGAC	0.483		NA											61	281					0	0	0	0
CYP11B1	1584	broad.mit.edu	37	8	143961145	143961145	+	Missense_Mutation	SNP	C	C	T	rs144224988	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:143961145C>T	uc003yxi.2	-	1	92	c.85G>A	c.(85-87)GCC>ACC	p.A29T	CYP11B1_uc003yxj.2_Missense_Mutation_p.A29T|CYP11B1_uc010mey.2_Missense_Mutation_p.A29T	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	29					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GGGACCCGGGCGGCTCTCGTG	0.642		NA							Familial_Hyperaldosteronism_type_I				42	218					0	0	0	0
ZNF623	9831	broad.mit.edu	37	8	144733541	144733541	+	Missense_Mutation	SNP	C	C	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr8:144733541C>A	uc003yzd.2	+	1	1588	c.1499C>A	c.(1498-1500)ACA>AAA	p.T500K	ZNF623_uc011lkp.1_Missense_Mutation_p.T460K|ZNF623_uc003yzc.2_Missense_Mutation_p.T460K	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	500					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AACTCAACTACAAACGTTAAA	0.413		NA											8	287					0.00307968	0.0032948	1	0
SVEP1	79987	broad.mit.edu	37	9	113168736	113168736	+	Silent	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr9:113168736G>A	uc010mtz.2	-	38	9481	c.9144C>T	c.(9142-9144)GCC>GCT	p.A3048A	SVEP1_uc010mty.2_Silent_p.A974A	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3048	Sushi 27.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACTGGCCATCGGCTTCACAGG	0.498		NA											49	31					0	0	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516492	138516492	+	Silent	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr9:138516492C>T	uc010nbd.1	-	5	536	c.282G>A	c.(280-282)CCG>CCA	p.P94P		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	94	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		AGTGTAGGAACGGCCTCAGGT	0.393		NA											22	84					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412263	139412263	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr9:139412263C>T	uc004chz.2	-	8	1382	c.1382G>A	c.(1381-1383)TGC>TAC	p.C461Y		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	461	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GTCGTTCTGGCACGGGTTCGA	0.652		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			52	27					0	0	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840150	27840150	+	Missense_Mutation	SNP	G	G	A			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chrX:27840150G>A	uc004dbw.2	+	3	954	c.727G>A	c.(727-729)GAG>AAG	p.E243K		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	243	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						CATGTTTGGGGAGCCCAGGAA	0.453		NA											6	54					0	0	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16952550	16952550	+	Missense_Mutation	SNP	C	C	T			TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chrY:16952550C>T	uc004ftg.2	+	6	2111	c.1859C>T	c.(1858-1860)TCA>TTA	p.S620L	NLGN4Y_uc004fte.2_Missense_Mutation_p.S452L|NLGN4Y_uc011nas.1_Missense_Mutation_p.S640L|NLGN4Y_uc004ftf.2_Missense_Mutation_p.S313L|NLGN4Y_uc004fth.2_Missense_Mutation_p.S620L	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	620	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						GACATGACATCATTTCCCTAT	0.493		NA											30	33					0	0	0	0
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	CCT	-	rs62639328	byFrequency	TCGA-BB-4225-01A-01D-1434-08	TCGA-BB-4225-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85fb5611-0dee-4a73-8aa1-1629ad929173	8785ede1-b3db-431b-b0dd-1b96a322cc2c	g.chr19:46299165_46299167delCCT	uc002pdm.2	-	6	2257_2259	c.2114_2116delAGG	c.(2113-2118)GAGGGC>GGC	p.E705del	RSPH6A_uc002pdl.2_In_Frame_Del_p.E441del	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	705	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						tcctcctcgccctcctcctcctc	0.438		NA											8	432	---	---	---	---	NA	NA	NA	NA