Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
C1orf158	93190	broad.mit.edu	37	1	12819314	12819314	+	Silent	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:12819314C>T	uc001auh.2	+	3	513	c.297C>T	c.(295-297)GAC>GAT	p.D99D	C1orf158_uc010obe.1_Silent_p.D99D	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	99										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GCACCTATGACGACCATTACA	0.567		NA											9	175					0	0	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166791	19166791	+	Silent	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:19166791G>A	uc001bba.1	-	6	1823	c.1822C>T	c.(1822-1824)CTG>TTG	p.L608L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	608	Helical; Name=2; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AGCAGTGTCAGCATCAGGAAG	0.632		NA											4	96					0	0	0	0
EIF4G3	8672	broad.mit.edu	37	1	21191633	21191633	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:21191633C>G	uc001bec.2	-	16	2833	c.2577G>C	c.(2575-2577)CAG>CAC	p.Q859H	EIF4G3_uc010odi.1_Missense_Mutation_p.Q463H|EIF4G3_uc010odj.1_Missense_Mutation_p.Q858H|EIF4G3_uc009vpz.2_Missense_Mutation_p.Q579H|EIF4G3_uc001bed.2_Missense_Mutation_p.Q859H|EIF4G3_uc001bef.2_Missense_Mutation_p.Q895H|EIF4G3_uc001bee.2_Missense_Mutation_p.Q865H	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	859	eIF3/EIF4A-binding (By similarity).|MIF4G.|HEAT 3.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CAAGTTCTTTCTGCTTCTTCT	0.408		NA											3	109					0	0	0	0
ARID1A	8289	broad.mit.edu	37	1	27089711	27089711	+	Silent	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:27089711C>T	uc001bmv.1	+	8	3040	c.2667C>T	c.(2665-2667)GGC>GGT	p.G889G	ARID1A_uc001bmt.1_Silent_p.G889G|ARID1A_uc001bmu.1_Silent_p.G889G|ARID1A_uc001bmw.1_Silent_p.G506G	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	889					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CACCAGGGGGCATGAACCGGA	0.567		NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								4	42					0	0	0	0
SFRS4	6429	broad.mit.edu	37	1	29475489	29475489	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:29475489C>G	uc001bro.2	-	6	1291	c.918G>C	c.(916-918)GAG>GAC	p.E306D	SFRS4_uc010ofy.1_3'UTR	NM_005626	NP_005617	Q08170	SRSF4_HUMAN	splicing factor, arginine/serine-rich 4	306	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)		ccactctcctctcctgactcc	0.189		NA											8	173					0	0	0	0
STIL	6491	broad.mit.edu	37	1	47717292	47717292	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:47717292C>A	uc001crc.1	-	17	3535	c.3380G>T	c.(3379-3381)GGA>GTA	p.G1127V	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.G1081V|STIL_uc010omo.1_Missense_Mutation_p.G1110V|STIL_uc001crd.1_Missense_Mutation_p.G1128V|STIL_uc001cre.1_Missense_Mutation_p.G1127V	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1127					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TTGTAGGAGTCCATATCTCTT	0.378		NA											7	164					0.00198382	0.00212942	1	0
SMG5	23381	broad.mit.edu	37	1	156237465	156237465	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr1:156237465C>T	uc001foc.3	-	10	1062	c.913G>A	c.(913-915)GTG>ATG	p.V305M	SMG5_uc009wrv.2_5'Flank	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	305					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TCTGAGTCCACGGAGCTACAG	0.572		NA											3	11					0	0	0	0
OR5D16	390144	broad.mit.edu	37	11	55606601	55606601	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr11:55606601T>C	uc010rio.1	+	1	374	c.374T>C	c.(373-375)TTT>TCT	p.F125S		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TATGACCACTTTGTGGCCATT	0.443		NA											4	123					0	0	0	0
DDX6	1656	broad.mit.edu	37	11	118625459	118625459	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr11:118625459C>G	uc001pub.2	-	13	1775	c.1414G>C	c.(1414-1416)GAA>CAA	p.E472Q	DDX6_uc001pua.2_Missense_Mutation_p.E172Q|DDX6_uc001puc.2_Missense_Mutation_p.E472Q	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	472					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		CTGTGGTATTCTGCCACATAC	0.423		NA	T	IGH@	B-NHL								7	159					0	0	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120316154	120316154	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr11:120316154T>A	uc001pxl.1	+	16	1333	c.1326T>A	c.(1324-1326)GAT>GAA	p.D442E	ARHGEF12_uc009zat.2_Missense_Mutation_p.D423E|ARHGEF12_uc010rzn.1_Missense_Mutation_p.D339E|ARHGEF12_uc009zau.1_Missense_Mutation_p.D339E	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	442	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CTGTTCCTGATGAAATGTCTG	0.353		NA	T	MLL	AML								3	86					0	0	0	0
ERC1	23085	broad.mit.edu	37	12	1221439	1221439	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:1221439A>T	uc001qjb.2	+	6	1617	c.1376A>T	c.(1375-1377)AAG>ATG	p.K459M	ERC1_uc001qiz.2_Intron|ERC1_uc001qjc.2_Intron|ERC1_uc001qja.2_Intron|ERC1_uc001qjd.2_Intron|ERC1_uc001qjf.2_Missense_Mutation_p.K459M|ERC1_uc010sdv.1_Intron|ERC1_uc009zdp.2_Missense_Mutation_p.K96M	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	459	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GAGCTGAAAAAGAAAGCGGCT	0.468		NA											7	127					0	0	0	0
CLEC4D	338339	broad.mit.edu	37	12	8672931	8672931	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:8672931G>A	uc001qun.2	+	5	687	c.494G>A	c.(493-495)CGC>CAC	p.R165H		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	165	C-type lectin.|Extracellular (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					TTTAACCCACGCAGAGTGTAA	0.418		NA											5	78					0	0	0	0
TMPO	7112	broad.mit.edu	37	12	98941400	98941400	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:98941400C>T	uc001tfj.2	+	9	1366	c.1129C>T	c.(1129-1131)CTC>TTC	p.L377F	TMPO_uc001tfk.2_Missense_Mutation_p.L268F|TMPO_uc001tfl.2_RNA	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	377	Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						GCCATTAGAACTCAGTGATTT	0.428		NA											6	58					0	0	0	0
SLC17A8	246213	broad.mit.edu	37	12	100784777	100784777	+	Splice_Site	SNP	A	A	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr12:100784777A>G	uc010svi.1	+	3	668	c.355_splice	c.e3-2	p.T119_splice	SLC17A8_uc009ztx.2_Splice_Site_p.T119_splice	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent						neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TCTCATTTCCAGACAGCACAG	0.378		NA											8	92					0	0	0	0
SKA3	221150	broad.mit.edu	37	13	21729856	21729856	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr13:21729856C>G	uc001unt.2	-	8	1308	c.1214G>C	c.(1213-1215)CGA>CCA	p.R405P	SKA3_uc001unv.2_Missense_Mutation_p.R323P|SKA3_uc001unu.2_Intron	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	405					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						GCTGACATCTCGGATGTTCTG	0.328		NA											8	120					0	0	0	0
TMEM55B	90809	broad.mit.edu	37	14	20928987	20928987	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:20928987C>G	uc001vxl.2	-	2	313	c.160G>C	c.(160-162)GAG>CAG	p.E54Q	TMEM55B_uc001vxk.2_Missense_Mutation_p.E61Q	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	54	Pro-rich.					integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		GGATGCCCCTCGGGAAACGGG	0.587		NA											4	96					0	0	0	0
MYH7	4625	broad.mit.edu	37	14	23884264	23884264	+	Silent	SNP	G	G	A	rs3729831		TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:23884264G>A	uc001wjx.2	-	37	5605	c.5499C>T	c.(5497-5499)AAC>AAT	p.N1833N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1833	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCGACTCTGCGTTGCGCTTCT	0.652		NA											7	154					0	0	0	0
ADCY4	196883	broad.mit.edu	37	14	24788554	24788554	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:24788554G>A	uc001wov.2	-	22	2828	c.2822C>T	c.(2821-2823)TCT>TTT	p.S941F	ADCY4_uc001wow.2_Missense_Mutation_p.S941F|ADCY4_uc010toh.1_Missense_Mutation_p.S627F|ADCY4_uc001wox.2_Missense_Mutation_p.S941F|ADCY4_uc001woy.2_Missense_Mutation_p.S941F	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	941	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		ATCCTGTCCAGAGGTGGCATT	0.527		NA											8	78					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64656947	64656947	+	Silent	SNP	C	C	T	rs145549349	by1000genomes	TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr14:64656947C>T	uc001xgm.2	+	99	18260	c.18030C>T	c.(18028-18030)ATC>ATT	p.I6010I	SYNE2_uc001xgl.2_Silent_p.I6010I|SYNE2_uc010apy.2_Silent_p.I2395I|SYNE2_uc001xgn.2_Silent_p.I972I|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Intron|SYNE2_uc001xgq.2_Silent_p.I375I	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6010	Spectrin 5.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTGATGTCATCGGATCAAGGT	0.403		NA											4	48					0	0	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562493	75562493	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr15:75562493C>A	uc002azs.1	+	18	2076	c.1999C>A	c.(1999-2001)CCG>ACG	p.P667T	uc002azu.1_5'Flank|uc010ulz.1_5'Flank	NM_001145224	NP_001138696	A6NDK9	GOG6C_HUMAN	golgi autoantigen, golgin subfamily a, 6D	679										ovary(1)	1						TGACAACCCCCCGGTACAGCA	0.602		NA											5	107					1.02e-07	1.14e-07	1	0
FES	2242	broad.mit.edu	37	15	91433125	91433125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr15:91433125C>T	uc002bpv.2	+	8	1078	c.982C>T	c.(982-984)CAG>TAG	p.Q328*	FES_uc010uqj.1_Nonsense_Mutation_p.Q270*|FES_uc010uqk.1_Nonsense_Mutation_p.Q310*|FES_uc002bpw.2_RNA|FES_uc010bny.2_Nonsense_Mutation_p.Q270*|FES_uc002bpx.2_Nonsense_Mutation_p.Q328*|FES_uc002bpy.2_Nonsense_Mutation_p.Q270*	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	328	Potential.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTTCAGGCGGCAGGAGATGGT	0.637		NA											6	142					0	0	0	0
KIAA0430	9665	broad.mit.edu	37	16	15718917	15718917	+	Silent	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr16:15718917C>T	uc002ddr.2	-	9	2260	c.2067G>A	c.(2065-2067)CCG>CCA	p.P689P	KIAA0430_uc002ddq.2_Silent_p.P545P|KIAA0430_uc010uzv.1_Silent_p.P685P|KIAA0430_uc010uzw.1_Silent_p.P687P	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	688						peroxisome	nucleotide binding|RNA binding				0						CCGAGTTTTTCGGCGTCGACA	0.483		NA											12	116					0	0	0	0
ZNF821	55565	broad.mit.edu	37	16	71898871	71898871	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr16:71898871T>A	uc010vmj.1	-	4	623	c.247A>T	c.(247-249)AAA>TAA	p.K83*	ATXN1L_uc010vmi.1_Intron|ZNF821_uc002fbe.2_5'UTR|ZNF821_uc002fbf.2_Nonsense_Mutation_p.K41*|ZNF821_uc002fbg.3_Intron|ZNF821_uc002fbh.3_Nonsense_Mutation_p.K41*|ZNF821_uc002fbi.3_5'UTR	NM_017530	NP_060000	O75541	ZN821_HUMAN	zinc finger protein 821	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCTCCACTTTGACCACCCCT	0.522		NA											11	124					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	rs28934576	by1000genomes	TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	22					0	0	0	0
COASY	80347	broad.mit.edu	37	17	40716511	40716511	+	Silent	SNP	C	C	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:40716511C>G	uc002hzz.2	+	4	1120	c.963C>G	c.(961-963)CTC>CTG	p.L321L	COASY_uc010cyj.2_Silent_p.L350L|COASY_uc002iab.2_Silent_p.L26L|COASY_uc002iad.2_Silent_p.L321L|COASY_uc002iac.2_Silent_p.L321L|COASY_uc002iae.2_Silent_p.L116L|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	321	Phosphopantetheine adenylyltransferase.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		TGAAGGACCTCAGACATACAG	0.527		NA											4	70					0	0	0	0
TTLL6	284076	broad.mit.edu	37	17	46847448	46847448	+	Silent	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:46847448G>A	uc010wlo.1	-	15	2087	c.2052C>T	c.(2050-2052)TCC>TCT	p.S684S	TTLL6_uc002iob.2_Silent_p.S377S|TTLL6_uc010dbi.2_Intron|TTLL6_uc002ioc.2_Silent_p.S437S|TTLL6_uc002iod.2_Intron	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	636						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						TGGTTTCTACGGAGGTTAAGT	0.443		NA											8	91					0	0	0	0
CHAD	1101	broad.mit.edu	37	17	48545610	48545610	+	Missense_Mutation	SNP	C	C	G	rs147638039	byFrequency	TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:48545610C>G	uc010dbr.2	-	1	618	c.565G>C	c.(565-567)GGG>CGG	p.G189R	ACSF2_uc002iqu.2_Intron|ACSF2_uc010wml.1_Intron|ACSF2_uc010wmm.1_Intron|ACSF2_uc010wmn.1_Intron|ACSF2_uc010wmo.1_Intron|CHAD_uc010dbs.2_Missense_Mutation_p.G189R|ACSF2_uc010dbt.1_5'Flank	NM_001267	NP_001258	O15335	CHAD_HUMAN	chondroadherin precursor	189	LRR 5.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(2)|central_nervous_system(1)	3	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TCCAGGGCCCCGGGCTGCAGG	0.637		NA											3	113					0	0	0	0
AXIN2	8313	broad.mit.edu	37	17	63554319	63554319	+	Silent	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr17:63554319C>T	uc002jfi.2	-	2	709	c.420G>A	c.(418-420)GAG>GAA	p.E140E	AXIN2_uc010den.1_Silent_p.E140E|AXIN2_uc002jfh.2_Silent_p.E140E|AXIN2_uc002jfj.1_Silent_p.E140E	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	140	RGS.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						TGCTGTTGTTCTCAATGTACC	0.453		NA							Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				6	176					0	0	0	0
ACTL9	284382	broad.mit.edu	37	19	8808007	8808007	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr19:8808007C>T	uc002mkl.2	-	1	1166	c.1045G>A	c.(1045-1047)GGC>AGC	p.G349S		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	349						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						CCCTCGAAGCCGGTGAAGAGC	0.637		NA											4	38					0	0	0	0
DPF1	8193	broad.mit.edu	37	19	38704349	38704349	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr19:38704349G>A	uc002ohl.2	-	9	922	c.895C>T	c.(895-897)CGG>TGG	p.R299W	DPF1_uc002ohm.2_Missense_Mutation_p.R343W|DPF1_uc002ohn.2_Missense_Mutation_p.R261W|DPF1_uc010xtu.1_Missense_Mutation_p.R317W|DPF1_uc010xtv.1_Missense_Mutation_p.R317W	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	299	PHD-type 1.				induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CGGTAGGTCCGCACGGCTGCC	0.667		NA											4	65					0	0	0	0
PRKCE	5581	broad.mit.edu	37	2	46203655	46203655	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr2:46203655T>G	uc002rut.2	+	3	697	c.500T>G	c.(499-501)GTC>GGC	p.V167G		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	167					activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			GTCCATCAGGTCAACGGCCAC	0.577		NA											6	72					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168100193	168100193	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr2:168100193A>G	uc002udx.2	+	8	2309	c.2291A>G	c.(2290-2292)AAG>AGG	p.K764R	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.K589R|XIRP2_uc010fpq.2_Missense_Mutation_p.K542R|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	589					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GACGTTGAAAAGGGAGATGTA	0.373		NA											3	60					0	0	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18123449	18123449	+	Missense_Mutation	SNP	G	G	A	rs34336937		TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr20:18123449G>A	uc002wqj.2	+	2	767	c.145G>A	c.(145-147)GAC>AAC	p.D49N	CSRP2BP_uc002wqk.2_5'Flank	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	49					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						GGCATCAGTGGACTTATCGCA	0.537		NA											4	83					0	0	0	0
DGCR2	9993	broad.mit.edu	37	22	19028791	19028791	+	Silent	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr22:19028791G>A	uc002zoq.1	-	9	1424	c.1176C>T	c.(1174-1176)CTC>CTT	p.L392L	DGCR2_uc002zor.1_Silent_p.L168L|DGCR2_uc011agr.1_Silent_p.L348L	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	392	Cytoplasmic (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TCCTGCGGCCGAGGTTGAAGT	0.627		NA											5	47					0	0	0	0
EIF3D	8664	broad.mit.edu	37	22	36916654	36916654	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr22:36916654G>A	uc003apq.2	-	7	663	c.547C>T	c.(547-549)CGC>TGC	p.R183C	EIF3D_uc011amr.1_Missense_Mutation_p.R10C|EIF3D_uc003apr.2_Missense_Mutation_p.R183C|EIF3D_uc011ams.1_Missense_Mutation_p.R86C|EIF3D_uc011amt.1_Missense_Mutation_p.R134C	NM_003753	NP_003744	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3	183						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			pancreas(1)	1						TCCAAGTAGCGCATCTTCATC	0.428		NA											3	46					0	0	0	0
CARD10	29775	broad.mit.edu	37	22	37891803	37891803	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr22:37891803C>T	uc003asx.1	-	14	2270	c.2267G>A	c.(2266-2268)CGG>CAG	p.R756Q	CARD10_uc003ast.1_RNA|CARD10_uc003asv.1_5'Flank|CARD10_uc011ank.1_Missense_Mutation_p.R74Q|CARD10_uc003asw.1_Missense_Mutation_p.R470Q|CARD10_uc003asy.1_Missense_Mutation_p.R756Q	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	756					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					GTCCAGGTCCCGCAGAGTGAG	0.642		NA											6	32					0	0	0	0
TTLL3	26140	broad.mit.edu	37	3	9860559	9860559	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr3:9860559G>C	uc003btg.2	+	6	700	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Intron|TTLL3_uc003btf.3_5'UTR|TTLL3_uc010hco.1_Missense_Mutation_p.E98Q|TTLL3_uc003bth.3_5'UTR|TTLL3_uc011atj.1_Missense_Mutation_p.E98Q|TTLL3_uc003btj.3_5'UTR|TTLL3_uc003bti.3_5'UTR	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	162	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					GGTGAAGTCTGAGTGGAAGTC	0.468		NA											6	173					0	0	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6083476	6083476	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr4:6083476G>A	uc003giu.3	-	6	1237	c.961C>T	c.(961-963)CGC>TGC	p.R321C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R321C|JAKMIP1_uc010idc.1_Missense_Mutation_p.R156C|JAKMIP1_uc010idd.1_Missense_Mutation_p.R321C|JAKMIP1_uc011bwc.1_Missense_Mutation_p.R156C|JAKMIP1_uc003giv.3_Missense_Mutation_p.R321C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R321C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	321	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCTCGTGAGCGTTTCAGCTGT	0.542		NA											6	70					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114290865	114290865	+	Silent	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr4:114290865G>A	uc003ibe.3	+	43	11614	c.11514G>A	c.(11512-11514)GAG>GAA	p.E3838E	ANK2_uc003ibd.3_Silent_p.E1744E|ANK2_uc003ibf.3_Silent_p.E1753E|ANK2_uc011cgc.1_Silent_p.E929E|ANK2_uc003ibg.3_Silent_p.E737E|ANK2_uc003ibh.3_Silent_p.E427E|ANK2_uc011cgd.1_Silent_p.E1140E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3805					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACAGAGAGGAGAGCTCTCCGC	0.542		NA											7	47					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126241841	126241841	+	Silent	SNP	T	T	C			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr4:126241841T>C	uc003ifj.3	+	1	4275	c.4275T>C	c.(4273-4275)ATT>ATC	p.I1425I		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1425	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGGAGATATTTTCAAGTCTA	0.423		NA											3	157					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13692178	13692178	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr5:13692178T>C	uc003jfd.2	-	79	13832	c.13790A>G	c.(13789-13791)TAC>TGC	p.Y4597C	DNAH5_uc003jfc.2_Missense_Mutation_p.Y765C	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4597					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGCGGCAATGTAGTTCAAGTC	0.483		NA							Kartagener_syndrome				4	76					0	0	0	0
TDRD6	221400	broad.mit.edu	37	6	46661019	46661019	+	Silent	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr6:46661019G>A	uc003oyj.2	+	1	5154	c.5154G>A	c.(5152-5154)CAG>CAA	p.Q1718Q	TDRD6_uc010jze.2_Silent_p.Q1712Q	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1718					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AGATAAAGCAGACTCTTGGGT	0.318		NA											3	59					0	0	0	0
NAPEPLD	222236	broad.mit.edu	37	7	102760426	102760426	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr7:102760426G>A	uc003vbc.2	-	3	867	c.539C>T	c.(538-540)GCG>GTG	p.A180V	NAPEPLD_uc003vbd.2_Missense_Mutation_p.A180V|NAPEPLD_uc011klj.1_Missense_Mutation_p.A253V|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	180					phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						GATAAGGACCGCATCTATTGG	0.463		NA											4	157					0	0	0	0
PAPPA	5069	broad.mit.edu	37	9	119124919	119124919	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr9:119124919G>A	uc004bjn.2	+	18	4777	c.4396G>A	c.(4396-4398)GGC>AGC	p.G1466S	PAPPA_uc011lxq.1_Missense_Mutation_p.G841S	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1466	Sushi 4.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CACCTGGAACGGCTCCTTCCA	0.532		NA											4	104					0	0	0	0
BEND2	139105	broad.mit.edu	37	X	18195820	18195820	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chrX:18195820G>A	uc004cyj.3	-	10	1653	c.1499C>T	c.(1498-1500)GCC>GTC	p.A500V	BEND2_uc010nfb.2_Missense_Mutation_p.A409V	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	500	BEN 1.									ovary(3)|kidney(1)|central_nervous_system(1)	5						CTTAGGTTTGGCCATATTTTG	0.393		NA											4	183					0	0	0	0
RBM10	8241	broad.mit.edu	37	X	47045133	47045133	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chrX:47045133C>T	uc004dhf.2	+	21	2753	c.2374C>T	c.(2374-2376)CGG>TGG	p.R792W	RBM10_uc004dhg.2_Missense_Mutation_p.R714W|RBM10_uc004dhh.2_Missense_Mutation_p.R791W|RBM10_uc010nhq.2_Missense_Mutation_p.R715W|RBM10_uc004dhi.2_Missense_Mutation_p.R857W	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	792					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						TGAGATTCACCGGCGAGCCCA	0.572		NA											6	22					0	0	0	0
PRSS54	221191	broad.mit.edu	37	16	58319891	58319892	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-CN-4733-01A-02D-1870-08	TCGA-CN-4733-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	12880a34-83d1-4075-b62a-9fc61d18ca09	7e2313fe-649e-42fd-8899-c002e6112c3f	g.chr16:58319891_58319892delGT	uc002enf.2	-	5	866_867	c.471_472delAC	c.(469-474)ACACCAfs	p.T157fs	PRSS54_uc002eng.2_Frame_Shift_Del_p.T157fs|PRSS54_uc010vie.1_Frame_Shift_Del_p.T58fs	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	157_158	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						AAGACTGGTGGTGTATGCAGCA	0.545		NA											7	93	---	---	---	---	NA	NA	NA	NA