Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ACTRT2	140625	broad.mit.edu	37	1	2938804	2938804	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:2938804C>T	uc001ajz.2	+	1	759	c.554C>T	c.(553-555)GCG>GTG	p.A185V		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	185						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CTCCACGTGGCGGGCAGGGAC	0.642		NA											12	79					0	0	0	0
KIF1B	23095	broad.mit.edu	37	1	10394634	10394634	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:10394634C>T	uc001aqx.3	+	28	3183	c.2981C>T	c.(2980-2982)GCC>GTC	p.A994V	KIF1B_uc001aqw.3_Missense_Mutation_p.A948V|KIF1B_uc001aqy.2_Missense_Mutation_p.A968V|KIF1B_uc001aqz.2_Missense_Mutation_p.A994V|KIF1B_uc001ara.2_Missense_Mutation_p.A954V|KIF1B_uc001arb.2_Missense_Mutation_p.A980V	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	994					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CACAGGGTGGCCATCGTCAGT	0.517		NA											75	187					0	0	0	0
ZBTB17	7709	broad.mit.edu	37	1	16270105	16270105	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:16270105C>T	uc001axl.3	-	11	1804	c.1565G>A	c.(1564-1566)CGC>CAC	p.R522H	ZBTB17_uc010obq.1_Missense_Mutation_p.R439H|ZBTB17_uc010obr.1_Missense_Mutation_p.R522H|ZBTB17_uc010obs.1_Missense_Mutation_p.R446H	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	522	C2H2-type 8.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TGTGTGAATGCGGACGTGCCG	0.662		NA											4	140					0	0	0	0
EPHB2	2048	broad.mit.edu	37	1	23191380	23191380	+	Silent	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:23191380C>T	uc009vqj.1	+	5	1123	c.978C>T	c.(976-978)TCC>TCT	p.S326S	EPHB2_uc001bge.2_Silent_p.S326S|EPHB2_uc001bgf.2_Silent_p.S326S|EPHB2_uc010odu.1_Silent_p.S326S|hsa-mir-4253|MI0015860_5'Flank	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	326	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CCATCCCCTCCGCGCCCCAGG	0.652		NA							Hereditary_Prostate_Cancer				16	116					0	0	0	0
COL8A2	1296	broad.mit.edu	37	1	36563712	36563712	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:36563712G>A	uc001bzv.1	-	2	1577	c.1570C>T	c.(1570-1572)CCC>TCC	p.P524S	COL8A2_uc001bzw.1_Missense_Mutation_p.P459S	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	524	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGGGGCCCGGGAGGCCCCGGA	0.756		NA											6	4					0	0	0	0
B4GALT2	8704	broad.mit.edu	37	1	44451059	44451059	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:44451059G>T	uc001clg.2	+	5	1220	c.850G>T	c.(850-852)GAC>TAC	p.D284Y	B4GALT2_uc001clh.2_Missense_Mutation_p.D218Y|B4GALT2_uc010okl.1_Missense_Mutation_p.D313Y|B4GALT2_uc001cli.2_Missense_Mutation_p.D284Y	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	284	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	CGAGGATGATGACATCTTCAA	0.597		NA											15	62					1.36e-06	1.44e-06	1	0
TAL1	6886	broad.mit.edu	37	1	47685565	47685565	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:47685565C>T	uc001cqx.2	-	4	1400	c.823G>A	c.(823-825)GCG>ACG	p.A275T	TAL1_uc009vyq.2_Silent_p.A31A|TAL1_uc001cqy.2_Missense_Mutation_p.A275T	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	275					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						TCTGGGGGCGCGccgccccct	0.582		NA	T	TRD@|SIL	lymphoblastic leukemia/biphasic								16	16					0	0	0	0
FGGY	55277	broad.mit.edu	37	1	60139745	60139745	+	Silent	SNP	C	C	A	rs114601020	by1000genomes	TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:60139745C>A	uc001czi.3	+	14	1664	c.1452C>A	c.(1450-1452)TCC>TCA	p.S484S	FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Silent_p.S508S|FGGY_uc001czj.3_Silent_p.S483S|FGGY_uc001czk.3_Silent_p.S372S|FGGY_uc001czl.3_Silent_p.S396S|FGGY_uc001czm.3_Silent_p.S185S	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	484					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					AGGTGGAGTCCGTTCTTGTGG	0.612		NA											9	26					4.69e-08	5.01e-08	1	0
NBPF10	100132406	broad.mit.edu	37	1	145311785	145311785	+	Splice_Site	SNP	C	C	G	rs61816394	by1000genomes	TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:145311785C>G	uc001end.3	+	14	1889	c.1854_splice	c.e14-1	p.R618_splice	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_5'Flank|NBPF10_uc010oyl.1_5'Flank|NBPF10_uc010oyj.1_5'Flank	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TACTTTTCCACGCTCAGCAGG	0.453		NA											3	121					0	0	0	0
IGSF8	93185	broad.mit.edu	37	1	160062156	160062156	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:160062156C>T	uc001fva.2	-	5	1687	c.1642G>A	c.(1642-1644)GCC>ACC	p.A548T	IGSF8_uc001fuz.2_Missense_Mutation_p.A548T|IGSF8_uc009wtf.2_Missense_Mutation_p.A548T	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	548	Ig-like C2-type 4.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGCACCCAGGCGCTGGGGGCA	0.647		NA											20	107					0	0	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159065	18159065	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr11:18159065T>C	uc001mnu.2	+	3	677	c.316T>C	c.(316-318)TAC>CAC	p.Y106H		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	106	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						GACCTTTCCCTACTTTATAGG	0.552		NA											44	230					0	0	0	0
HARBI1	283254	broad.mit.edu	37	11	46637146	46637146	+	Silent	SNP	C	C	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr11:46637146C>A	uc001ncy.2	-	2	890	c.642G>T	c.(640-642)GCG>GCT	p.A214A	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	214						cytoplasm|nucleus	metal ion binding|nuclease activity				0						TGTGCATACCCGCTTCAAACT	0.428		NA											37	215					3.75e-06	3.94e-06	1	0
MS4A10	341116	broad.mit.edu	37	11	60561573	60561573	+	Silent	SNP	C	C	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr11:60561573C>A	uc001npz.1	+	5	585	c.489C>A	c.(487-489)TCC>TCA	p.S163S		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	163	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2						ACCCCAACTCCACGGTGAGTA	0.567		NA											4	159					0.00909568	0.00919348	1	0
NOP2	4839	broad.mit.edu	37	12	6666429	6666429	+	Silent	SNP	T	T	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:6666429T>A	uc001qph.1	-	16	2337	c.2157A>T	c.(2155-2157)ACA>ACT	p.T719T	IFFO1_uc001qpe.1_5'Flank|IFFO1_uc010sfe.1_5'Flank|IFFO1_uc001qpf.1_5'Flank|IFFO1_uc001qpc.1_5'Flank|IFFO1_uc001qpd.1_5'Flank|NOP2_uc009zeq.1_3'UTR|NOP2_uc001qpi.1_Silent_p.T719T|NOP2_uc001qpj.1_Silent_p.T148T	NM_001033714	NP_001028886	P46087	NOP2_HUMAN	nucleolar protein 1, 120kDa	723					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						TTTGTGTGTCTGTGCCCTTGG	0.537		NA											62	436					0	0	0	0
SOX5	6660	broad.mit.edu	37	12	23689485	23689485	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:23689485C>A	uc001rfw.2	-	14	1992	c.1890G>T	c.(1888-1890)AAG>AAT	p.K630N	SOX5_uc001rfx.2_Missense_Mutation_p.K617N|SOX5_uc001rfy.2_Missense_Mutation_p.K509N|SOX5_uc001rfv.2_Missense_Mutation_p.K244N|SOX5_uc010siv.1_Missense_Mutation_p.K617N|SOX5_uc010siw.1_RNA	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	630					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GGCAGGTGCGCTTTGGCCTGG	0.517		NA											33	136					1.22e-17	1.34e-17	1	0
MLL2	8085	broad.mit.edu	37	12	49425421	49425421	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:49425421C>T	uc001rta.3	-	39	13067	c.13067G>A	c.(13066-13068)GGG>GAG	p.G4356E		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4356	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGAGACCCTCCCAGGAGGCGG	0.622		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			3	26					0	0	0	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:57485446T>C	uc001smz.2	+	2	1000	c.622T>C	c.(622-624)TTC>CTC	p.F208L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCGCCCCCCTTCTCCCCCCC	0.716		NA											4	34					0	0	0	0
PTPRB	5787	broad.mit.edu	37	12	70956847	70956847	+	Silent	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:70956847G>A	uc001swb.3	-	14	3321	c.3291C>T	c.(3289-3291)TCC>TCT	p.S1097S	PTPRB_uc010sto.1_Silent_p.S1007S|PTPRB_uc010stp.1_Silent_p.S1007S|PTPRB_uc001swc.3_Silent_p.S1315S|PTPRB_uc001swa.3_Silent_p.S1227S|PTPRB_uc001swd.3_Silent_p.S1314S|PTPRB_uc009zrr.1_Silent_p.S1194S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1097	Fibronectin type-III 13.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGTGCCTGGTGGAGTTCTCTG	0.562		NA											4	47					0	0	0	0
ACACB	32	broad.mit.edu	37	12	109610133	109610133	+	Silent	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr12:109610133G>A	uc001tob.2	+	6	1208	c.1089G>A	c.(1087-1089)CTG>CTA	p.L363L	ACACB_uc001toc.2_Silent_p.L363L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	363	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TTCCGGAGCTGCTGTGCAAGA	0.512		NA											127	300					0	0	0	0
USPL1	10208	broad.mit.edu	37	13	31205139	31205139	+	Silent	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr13:31205139C>T	uc001utc.2	+	4	828	c.396C>T	c.(394-396)GAC>GAT	p.D132D	USPL1_uc001utb.2_Translation_Start_Site|USPL1_uc001utd.2_Intron	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	132					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		TTGCTATTGACGGTGGAAAAG	0.368		NA											24	49					0	0	0	0
LCP1	3936	broad.mit.edu	37	13	46701815	46701815	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr13:46701815C>G	uc001vaz.3	-	16	1921	c.1795G>C	c.(1795-1797)GCC>CCC	p.A599P	LCP1_uc010ack.2_Missense_Mutation_p.A168P|LCP1_uc001vay.3_Missense_Mutation_p.A196P|LCP1_uc001vba.3_Missense_Mutation_p.A599P	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	599	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCTGGCAGGGCATACACTCTT	0.488		NA	T	BCL6	NHL 								10	294					0	0	0	0
TEP1	7011	broad.mit.edu	37	14	20854732	20854732	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr14:20854732C>T	uc001vxe.2	-	19	2775	c.2735G>A	c.(2734-2736)GGG>GAG	p.G912E	TEP1_uc010ahk.2_Missense_Mutation_p.G262E|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.G804E	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	912					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GTCCCGCTCCCCATGCATGTC	0.622		NA											9	28					0	0	0	0
BCL11B	64919	broad.mit.edu	37	14	99641386	99641386	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr14:99641386C>T	uc001yga.2	-	4	2054	c.1787G>A	c.(1786-1788)GGC>GAC	p.G596D	BCL11B_uc001ygb.2_Missense_Mutation_p.G525D	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	596	Gly-rich.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CATGACCTTGCCCAGCACCAG	0.542		NA	T	TLX3	T-ALL								9	61					0	0	0	0
LINS1	55180	broad.mit.edu	37	15	101120660	101120660	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr15:101120660C>A	uc002bwe.2	-	3	679	c.388G>T	c.(388-390)GAT>TAT	p.D130Y	LINS1_uc002bwf.2_Missense_Mutation_p.D130Y|LINS1_uc002bwg.2_Missense_Mutation_p.D130Y|LINS1_uc002bwh.2_Missense_Mutation_p.D130Y|LINS1_uc010usa.1_Intron|LINS1_uc002bwi.2_Missense_Mutation_p.D130Y	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	130											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			AATTTAGAATCGACTTTGGCT	0.313		NA											13	81					9.05e-12	9.84e-12	1	0
ARMC5	79798	broad.mit.edu	37	16	31477726	31477726	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr16:31477726G>A	uc002ecc.2	+	6	2853	c.2324G>A	c.(2323-2325)CGG>CAG	p.R775Q	ARMC5_uc010vfn.1_Missense_Mutation_p.R870Q|ARMC5_uc010vfo.1_Missense_Mutation_p.R807Q|ARMC5_uc002eca.3_3'UTR|ARMC5_uc010vfp.1_Missense_Mutation_p.R583Q|ARMC5_uc002ecb.2_3'UTR	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	775	BTB.						binding			pancreas(1)	1						CCTTTCTTCCGGGCCCTGCTG	0.667		NA											8	30					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578427	7578427	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:7578427T>A	uc002gim.2	-	5	697	c.503A>T	c.(502-504)CAC>CTC	p.H168L	TP53_uc002gig.1_Missense_Mutation_p.H168L|TP53_uc002gih.2_Missense_Mutation_p.H168L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H36L|TP53_uc010cng.1_Missense_Mutation_p.H36L|TP53_uc002gii.1_Missense_Mutation_p.H36L|TP53_uc010cnh.1_Missense_Mutation_p.H168L|TP53_uc010cni.1_Missense_Mutation_p.H168L|TP53_uc002gij.2_Missense_Mutation_p.H168L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H75L|TP53_uc002gio.2_Missense_Mutation_p.H36L|TP53_uc010vug.1_Missense_Mutation_p.H129L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	168	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		QH -> HD (in a sporadic cancer; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|HM -> LI (in a sporadic cancer; somatic mutation).|QH -> YL (in a sporadic cancer; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> V (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|H -> R (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H168R(12)|p.H168P(9)|p.H168Y(9)|p.0?(7)|p.H168L(5)|p.H168H(4)|p.H168fs*2(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.Y163fs*1(1)|p.P151_V173del23(1)|p.S149fs*72(1)|p.H168_M169>LI(1)|p.H168fs*13(1)|p.H168fs*5(1)|p.H168Q(1)|p.H168fs*69(1)|p.Q167fs*12(1)|p.H168D(1)|p.Q167_H168>HD(1)|p.H168N(1)|p.Q167_H168>YL(1)|p.H168fs*3(1)|p.H168fs*4(1)|p.Q165_M169delQSQHM(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCCGTCATGTGCTGTGACTG	0.652		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	48					0	0	0	0
MFSD6L	162387	broad.mit.edu	37	17	8701070	8701070	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:8701070C>T	uc002glp.1	-	1	1517	c.1369G>A	c.(1369-1371)GTC>ATC	p.V457I		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	457	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						ATGGGGAGGACGGACCACCAG	0.612		NA											35	128					0	0	0	0
TTC25	83538	broad.mit.edu	37	17	40117329	40117329	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:40117329C>T	uc002hyj.3	+	11	1936	c.1847C>T	c.(1846-1848)TCG>TTG	p.S616L	TTC25_uc010cxt.2_RNA|CNP_uc002hyk.1_5'Flank|CNP_uc002hyl.1_5'Flank|CNP_uc010wfz.1_5'Flank|CNP_uc002hym.1_5'Flank|CNP_uc010wga.1_5'Flank	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	616						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				AGGAGGCCTTCGGGAGAATTA	0.463		NA											7	30					0	0	0	0
ENPP7	339221	broad.mit.edu	37	17	77711840	77711840	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:77711840G>A	uc002jxa.2	+	5	1392	c.1372G>A	c.(1372-1374)GCA>ACA	p.A458T		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	458					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GTCTGAGGTCGCATAACGCCC	0.642		NA											5	195					0	0	0	0
MYOM1	8736	broad.mit.edu	37	18	3215034	3215034	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr18:3215034C>T	uc002klp.2	-	2	522	c.188G>A	c.(187-189)CGG>CAG	p.R63Q	MYOM1_uc002klq.2_Missense_Mutation_p.R63Q	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	63						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGCGGACGCCCGACGGAAGGC	0.687		NA											11	33					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr18:14513764C>T	uc010dln.2	-	10	1884	c.1430G>A	c.(1429-1431)CGG>CAG	p.R477Q	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	477										skin(3)	3						AAGTTGTTTCCGGGTATCATT	0.358		NA											3	86					0	0	0	0
LMNB2	84823	broad.mit.edu	37	19	2434446	2434446	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr19:2434446C>T	uc002lvy.2	-	7	1076	c.989G>A	c.(988-990)CGG>CAG	p.R330Q	LMNB2_uc002lwa.1_Missense_Mutation_p.R350Q	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	330	Rod.|Coil 2.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCATCTTCCGGAACTTGTC	0.667		NA											6	77					0	0	0	0
ZNF844	284391	broad.mit.edu	37	19	12187443	12187443	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr19:12187443C>G	uc002mtb.2	+	4	1651	c.1508C>G	c.(1507-1509)CCT>CGT	p.P503R	ZNF844_uc010dym.1_Missense_Mutation_p.P346R	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGAAACCCTATGAGTGTA	0.413		NA											3	100					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22362786	22362786	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr19:22362786T>A	uc002nqs.1	-	3	2051	c.1733A>T	c.(1732-1734)TAT>TTT	p.Y578F		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	578	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTTCTTATGATAACTAACAGT	0.353		NA											14	98					0	0	0	0
GFPT1	2673	broad.mit.edu	37	2	69556851	69556851	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:69556851C>T	uc002sfh.2	-	15	1687	c.1508G>A	c.(1507-1509)CGC>CAC	p.R503H		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	521					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						GATCTCTTTGCGTCTTTCTTG	0.408		NA											30	117					0	0	0	0
TXNDC9	10190	broad.mit.edu	37	2	99949494	99949494	+	Silent	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:99949494C>T	uc002szz.2	-	2	371	c.180G>A	c.(178-180)CAG>CAA	p.Q60Q	TXNDC9_uc010yvp.1_Silent_p.Q77Q|TXNDC9_uc002taa.1_Silent_p.Q60Q	NM_005783	NP_005774	O14530	TXND9_HUMAN	thioredoxin domain containing 9	60					cell redox homeostasis		protein binding				0						CTTGTTTCTGCTGTTGAGCTT	0.388		NA											42	143					0	0	0	0
MKI67IP	84365	broad.mit.edu	37	2	122485367	122485367	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:122485367T>A	uc002tnk.2	-	7	892	c.815A>T	c.(814-816)GAA>GTA	p.E272V	uc002tnj.1_Intron	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	272					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TTGTATTTCTTCTTTTACACA	0.323		NA											32	151					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179399515	179399515	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr2:179399515C>A	uc010zfg.1	-	307	94347	c.94123G>T	c.(94123-94125)GAA>TAA	p.E31375*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E25070*|TTN_uc010zfi.1_Nonsense_Mutation_p.E25003*|TTN_uc010zfj.1_Nonsense_Mutation_p.E24878*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32302							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATATTTTCTGGTCTAATG	0.368		NA											48	63					2.13e-23	2.37e-23	1	0
GZF1	64412	broad.mit.edu	37	20	23350773	23350773	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr20:23350773G>A	uc010gdb.2	+	7	2005	c.1831G>A	c.(1831-1833)GAT>AAT	p.D611N	GZF1_uc002wsy.2_Missense_Mutation_p.D611N|GZF1_uc010zsq.1_Missense_Mutation_p.D135N|GZF1_uc010zsr.1_Missense_Mutation_p.D120N|GZF1_uc002wsz.2_Missense_Mutation_p.D611N	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	611					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					TGTCATTGTAGATGGCTCGCC	0.418		NA											30	67					0	0	0	0
FAM193A	8603	broad.mit.edu	37	4	2641515	2641515	+	Silent	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:2641515C>T	uc010icl.2	+	4	570	c.219C>T	c.(217-219)CAC>CAT	p.H73H	FAM193A_uc010ick.2_Silent_p.H273H|FAM193A_uc003gfd.2_Silent_p.H73H|FAM193A_uc011bvm.1_Silent_p.H73H|FAM193A_uc011bvn.1_Silent_p.H73H|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	73										ovary(3)	3						ATAATAAACACCTGTTTGAAA	0.398		NA											20	86					0	0	0	0
PROM1	8842	broad.mit.edu	37	4	16035066	16035066	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:16035066G>A	uc003goo.2	-	4	582	c.370C>T	c.(370-372)CCT>TCT	p.P124S	PROM1_uc003gor.2_Missense_Mutation_p.P124S|PROM1_uc003gos.2_Missense_Mutation_p.P115S|PROM1_uc003got.2_Missense_Mutation_p.P124S|PROM1_uc003gou.2_Missense_Mutation_p.P115S|PROM1_uc003gop.2_Missense_Mutation_p.P115S|PROM1_uc003goq.3_Missense_Mutation_p.P115S|PROM1_uc010iec.1_Missense_Mutation_p.P2S	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	124	Helical; (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						CCCACCAGAGGCATCAGAATA	0.428		NA											7	35					0	0	0	0
EPHA5	2044	broad.mit.edu	37	4	66270139	66270139	+	Silent	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:66270139C>T	uc003hcy.2	-	8	1936	c.1743G>A	c.(1741-1743)GTG>GTA	p.V581V	EPHA5_uc003hcx.2_Silent_p.V513V|EPHA5_uc003hcz.2_Silent_p.V581V|EPHA5_uc011cah.1_Silent_p.V582V|EPHA5_uc011cai.1_Silent_p.V582V|EPHA5_uc003hda.2_Silent_p.V582V	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	581	Helical; (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AAATGACTCCCACTGTCACAG	0.473		NA								TSP Lung(17;0.13)			10	100					0	0	0	0
GC	2638	broad.mit.edu	37	4	72618359	72618359	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:72618359T>C	uc003hge.2	-	11	1424	c.1271A>G	c.(1270-1272)GAG>GGG	p.E424G	GC_uc003hgd.2_Missense_Mutation_p.E302G|GC_uc010iie.2_Missense_Mutation_p.E424G|GC_uc010iif.2_Missense_Mutation_p.E443G	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	424	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTTTAGTCGCTCTGCCAGTCT	0.373		NA											18	157					0	0	0	0
SHROOM3	57619	broad.mit.edu	37	4	77675899	77675899	+	Silent	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:77675899G>A	uc011cbx.1	+	7	5216	c.4263G>A	c.(4261-4263)TCG>TCA	p.S1421S	SHROOM3_uc003hkg.2_Silent_p.S1199S	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1421					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			AGAGGGTCTCGCTGCCTCAGT	0.607		NA											13	61					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187518256	187518256	+	Silent	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr4:187518256G>A	uc003izf.2	-	25	12626	c.12438C>T	c.(12436-12438)CAC>CAT	p.H4146H	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_Silent_p.H37H	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4146	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GATAGGAGCCGTGCGTGTTCT	0.587		NA								HNSCC(5;0.00058)			10	50					0	0	0	0
KIF4B	285643	broad.mit.edu	37	5	154394335	154394335	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr5:154394335C>G	uc010jih.1	+	1	1076	c.916C>G	c.(916-918)CAC>GAC	p.H306D		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	306	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGGTAACAGCCACACTCTTAT	0.438		NA											57	175					0	0	0	0
EXOC2	55770	broad.mit.edu	37	6	564672	564672	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:564672C>T	uc003mtd.2	-	15	1674	c.1540G>A	c.(1540-1542)GTG>ATG	p.V514M	EXOC2_uc003mte.2_Missense_Mutation_p.V514M|EXOC2_uc011dho.1_Missense_Mutation_p.V109M	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	514					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GTAAGCTTCACCAGGGAGTGC	0.507		NA											16	94					0	0	0	0
PKHD1	5314	broad.mit.edu	37	6	51927390	51927390	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:51927390C>T	uc003pah.1	-	14	1321	c.1045G>A	c.(1045-1047)GGG>AGG	p.G349R	PKHD1_uc003pai.2_Missense_Mutation_p.G349R	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	349	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CACCTGTACCCTGGGGTGGCT	0.478		NA											44	209					0	0	0	0
ENPP3	5169	broad.mit.edu	37	6	132006590	132006590	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:132006590G>T	uc003qcu.3	+	14	1554	c.1207G>T	c.(1207-1209)GCC>TCC	p.A403S	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.A403S	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	403	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CGAAGGGCCTGCCCCCCGCAT	0.363		NA											51	269					2.42e-19	2.66e-19	1	0
SYNE1	23345	broad.mit.edu	37	6	152660381	152660381	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr6:152660381G>T	uc010kiw.2	-	75	12948	c.12346C>A	c.(12346-12348)CAA>AAA	p.Q4116K	SYNE1_uc003qot.3_Missense_Mutation_p.Q4045K|SYNE1_uc003qou.3_Missense_Mutation_p.Q4116K|SYNE1_uc010kja.1_Missense_Mutation_p.Q821K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4116	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTACCGTTTGCTCTGTTTGT	0.378		NA								HNSCC(10;0.0054)			32	70					2e-19	2.21e-19	1	0
RBAK	57786	broad.mit.edu	37	7	5104738	5104738	+	Silent	SNP	T	T	C			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr7:5104738T>C	uc010kss.1	+	6	1975	c.1651T>C	c.(1651-1653)TTG>CTG	p.L551L	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Silent_p.L551L	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	551	Interaction with AR.|C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		ATTCAATGAGTTGTCATACTA	0.388		NA											16	112					0	0	0	0
RNF216	54476	broad.mit.edu	37	7	5662726	5662726	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr7:5662726G>A	uc003soy.1	-	17	2556	c.2366C>T	c.(2365-2367)CCG>CTG	p.P789L	RNF216_uc010ksz.1_Missense_Mutation_p.P411L|RNF216_uc010kta.1_Missense_Mutation_p.P411L|RNF216_uc011jwj.1_Missense_Mutation_p.P411L|RNF216_uc003sox.1_Missense_Mutation_p.P846L	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	789	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CAGGTTCTGCGGAACGGGCCT	0.627		NA											13	75					0	0	0	0
SRRT	51593	broad.mit.edu	37	7	100484755	100484755	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr7:100484755C>T	uc003uwy.2	+	16	2177	c.1909C>T	c.(1909-1911)CCC>TCC	p.P637S	SRRT_uc010lhl.1_Missense_Mutation_p.P636S|SRRT_uc003uxa.2_Missense_Mutation_p.P636S|SRRT_uc003uwz.2_Missense_Mutation_p.P637S	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	637					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GGACGAGATGCCCAATCGCTG	0.572		NA											5	283					0	0	0	0
CHD7	55636	broad.mit.edu	37	8	61765872	61765872	+	Silent	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr8:61765872C>T	uc003xue.2	+	31	7065	c.6588C>T	c.(6586-6588)ACC>ACT	p.T2196T		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2196	Glu-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAGAAGAAACCGATGGCAGCG	0.532		NA											8	60					0	0	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885104	88885104	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr8:88885104C>T	uc003ydz.2	-	1	1193	c.1096G>A	c.(1096-1098)GTG>ATG	p.V366M		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	366										ovary(1)	1						GAGAAGGCCACACTGGGAATG	0.592		NA											19	183					0	0	0	0
KIAA1539	80256	broad.mit.edu	37	9	35107972	35107972	+	Silent	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr9:35107972C>T	uc003zwl.2	-	3	625	c.300G>A	c.(298-300)GGG>GGA	p.G100G	KIAA1539_uc003zwm.2_Silent_p.G100G|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Silent_p.G100G|KIAA1539_uc003zwp.1_Silent_p.G100G|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	100						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GGCCTAAGAGCCCCACAGTAG	0.622		NA											21	234					0	0	0	0
ZNF883	169834	broad.mit.edu	37	9	115759475	115759475	+	Silent	SNP	A	A	G			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr9:115759475A>G	uc011lwy.1	-	5	2304	c.1065T>C	c.(1063-1065)GGT>GGC	p.G355G		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	355	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAAGACATCACCACACTTAG	0.398		NA											11	69					0	0	0	0
COBRA1	25920	broad.mit.edu	37	9	140161436	140161436	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr9:140161436C>T	uc004cmm.3	+	9	1339	c.1136C>T	c.(1135-1137)TCC>TTC	p.S379F		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	379					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		ATGCTCATGTCCTTCCTGGTG	0.587		NA											12	65					0	0	0	0
KIAA0467	23334	broad.mit.edu	37	1	43900933	43900933	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr1:43900933delT	uc001cjk.1	+	27	3732	c.3270delT	c.(3268-3270)AGTfs	p.S1090fs		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1989						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGCCGAGAGTGAAGAAGATC	0.572		NA											16	138	---	---	---	---	NA	NA	NA	NA
KIF18B	146909	broad.mit.edu	37	17	43012716	43012719	+	Frame_Shift_Del	DEL	TGCC	TGCC	-			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr17:43012716_43012719delTGCC	uc010wji.1	-	3	480_483	c.379_382delGGCA	c.(379-384)GGCATCfs	p.G127fs	KIF18B_uc002iht.2_Frame_Shift_Del_p.G127fs|KIF18B_uc010wjh.1_Frame_Shift_Del_p.G127fs	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				AGGTACATGATGCCGGGGTCCCCC	0.637		NA											9	58	---	---	---	---	NA	NA	NA	NA
ZNF611	81856	broad.mit.edu	37	19	53208627	53208638	+	In_Frame_Del	DEL	TATGAATTCTAG	TATGAATTCTAG	-	rs151210254	by1000genomes	TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr19:53208627_53208638delTATGAATTCTAG	uc002pzz.2	-	7	1987_1998	c.1670_1681delCTAGAATTCATA	c.(1669-1683)ACTAGAATTCATAGT>AGT	p.TRIH557del	ZNF611_uc010eqc.2_In_Frame_Del_p.TRIH487del|ZNF611_uc010ydo.1_In_Frame_Del_p.TRIH487del|ZNF611_uc010ydr.1_In_Frame_Del_p.TRIH488del|ZNF611_uc010ydp.1_In_Frame_Del_p.TRIH557del|ZNF611_uc010ydq.1_In_Frame_Del_p.TRIH557del|ZNF611_uc002qaa.3_In_Frame_Del_p.TRIH487del	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	557_560	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TTCTCTCCACTATGAATTCTAGTATGTTTTGC	0.406		NA											62	403	---	---	---	---	NA	NA	NA	NA
DEFB118	117285	broad.mit.edu	37	20	29960672	29960672	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-4737-01A-01D-1434-08	TCGA-CN-4737-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4c6857bb-f20f-4ac9-9c2c-cb83c5387a74	5afbe444-612c-47f3-bec3-96ceabdf9d1c	g.chr20:29960672delA	uc002wvr.2	+	2	97	c.71delA	c.(70-72)GAAfs	p.E24fs		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	24					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TATAGTGGTGAAAAAAAATGC	0.398		NA											15	70	---	---	---	---	NA	NA	NA	NA