Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CDK11A	728642	broad.mit.edu	37	1	1635057	1635057	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:1635057C>T	uc009vks.2	-	18	2026	c.1918G>A	c.(1918-1920)GGG>AGG	p.G640R	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Missense_Mutation_p.G147R|CDK11A_uc009vkp.2_Missense_Mutation_p.G257R|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Missense_Mutation_p.G630R	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	643	Protein kinase.				apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						CTGGGGGTCCCCAGCTCCTGA	0.572		NA											3	7					0	0	0	0
FBLIM1	54751	broad.mit.edu	37	1	16096922	16096922	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:16096922A>G	uc001axd.1	+	7	1003	c.560A>G	c.(559-561)CAC>CGC	p.H187R	FBLIM1_uc001axe.1_Missense_Mutation_p.H187R|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.H187R|FBLIM1_uc001axh.1_Missense_Mutation_p.H90R|FBLIM1_uc001axi.1_Missense_Mutation_p.H90R	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	187	LIM zinc-binding 1.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		GCCTTCTGCCACAAGACCGTG	0.637		NA											35	50					0	0	0	0
FBLIM1	54751	broad.mit.edu	37	1	16097009	16097009	+	Missense_Mutation	SNP	G	G	A	rs138675454		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:16097009G>A	uc001axd.1	+	7	1090	c.647G>A	c.(646-648)CGC>CAC	p.R216H	FBLIM1_uc001axe.1_Missense_Mutation_p.R216H|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.R216H|FBLIM1_uc001axh.1_Missense_Mutation_p.R119H|FBLIM1_uc001axi.1_Missense_Mutation_p.R119H	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	216	LIM zinc-binding 1.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		ACCTGCCGCCGCCAGCTGGCT	0.592		NA											22	51					0	0	0	0
UBR4	23352	broad.mit.edu	37	1	19436918	19436918	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:19436918G>T	uc001bbi.2	-	80	11937	c.11933C>A	c.(11932-11934)TCT>TAT	p.S3978Y		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3978					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CTTGGAGATAGAATCCGTCAG	0.537		NA											28	60					1.07e-15	1.25e-15	1	0
RAP1GAP	5909	broad.mit.edu	37	1	21924900	21924900	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:21924900G>C	uc001bex.2	-	22	2130	c.1872C>G	c.(1870-1872)AGC>AGG	p.S624R	RAP1GAP_uc001bev.2_Missense_Mutation_p.S709R|RAP1GAP_uc001bew.2_Missense_Mutation_p.S688R|RAP1GAP_uc001bey.2_Missense_Mutation_p.S650R	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	624					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		TACCTGGGGAGCTGCCCCCAC	0.622		NA											4	91					0	0	0	0
TRIM63	84676	broad.mit.edu	37	1	26392775	26392775	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:26392775T>G	uc001bli.1	-	2	452	c.316A>C	c.(316-318)AAA>CAA	p.K106Q		NM_032588	NP_115977	Q969Q1	TRI63_HUMAN	muscle specific ring finger protein 1	106	Interaction with TTN.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CACTCCTGTTTGTAGATGTCG	0.622		NA											3	162					0	0	0	0
C1orf91	56063	broad.mit.edu	37	1	32682796	32682796	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:32682796G>A	uc009vub.1	-	4	395	c.392C>T	c.(391-393)TCC>TTC	p.S131F	C1orf91_uc001buo.3_Intron|C1orf91_uc001bup.3_Intron|C1orf91_uc010oha.1_Intron|C1orf91_uc001buq.3_Intron			Q8WY98	TM234_HUMAN	RecName: Full=UPF0546 membrane protein C1orf91;	Error:Variant_position_missing_in_Q8WY98_after_alignment						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TTCTGGGAAGGAACTAACACA	0.532		NA											16	22					0	0	0	0
PLK3	1263	broad.mit.edu	37	1	45271192	45271192	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:45271192C>A	uc001cmn.2	+	15	1883	c.1783C>A	c.(1783-1785)CTC>ATC	p.L595I	PLK3_uc001cmo.2_RNA|BTBD19_uc010old.1_5'Flank|BTBD19_uc010ole.1_5'Flank	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	595	POLO box 2.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					CAAGCTGATTCTCAGTGGCTG	0.597		NA											173	217					1.49e-95	1.81e-95	1	0
UROD	7389	broad.mit.edu	37	1	45481099	45481099	+	Missense_Mutation	SNP	A	A	G	rs142869188		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:45481099A>G	uc001cna.1	+	10	1141	c.1033A>G	c.(1033-1035)ATG>GTG	p.M345V	UROD_uc001cnb.1_Missense_Mutation_p.M310V|UROD_uc001cnc.1_Missense_Mutation_p.M250V	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	345						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					TTATCCTGACATGGACCCAGA	0.527		NA							Porphyria_Cutanea_Tarda_Type_II				43	54					0	0	0	0
MAST2	23139	broad.mit.edu	37	1	46471917	46471917	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:46471917C>G	uc001cov.2	+	8	1035	c.752C>G	c.(751-753)TCA>TGA	p.S251*	MAST2_uc001cow.2_Nonsense_Mutation_p.S251*|MAST2_uc001cox.1_Nonsense_Mutation_p.S115*|MAST2_uc001coy.1_Translation_Start_Site|MAST2_uc001coz.1_Nonsense_Mutation_p.S136*|MAST2_uc009vya.2_Nonsense_Mutation_p.S173*|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	251					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CTCTAGTCATCATGCTCCTCA	0.478		NA											7	282					0	0	0	0
DOCK7	85440	broad.mit.edu	37	1	62954604	62954604	+	Splice_Site	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:62954604C>A	uc001daq.2	-	42	5500	c.5466_splice	c.e42+1	p.Q1822_splice	DOCK7_uc001dan.2_Splice_Site_p.Q1683_splice|DOCK7_uc001dao.2_Splice_Site_p.Q1683_splice|DOCK7_uc001dap.2_Splice_Site_p.Q1800_splice|DOCK7_uc001dam.2_Splice_Site_p.Q1002_splice|DOCK7_uc010oov.1_Splice_Site_p.Q561_splice	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7						activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GGAATCATTACCTGATGAACA	0.353		NA											18	67					1.16e-05	1.29e-05	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74492542	74492542	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:74492542C>T	uc001dfy.3	-	8	2022	c.1830G>A	c.(1828-1830)GTG>GTA	p.V610V	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	610	Potential.									ovary(2)	2						AATTTGTTTTCACAATTGCTA	0.284		NA											26	38					0	0	0	0
CELSR2	1952	broad.mit.edu	37	1	109794495	109794495	+	Silent	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:109794495G>C	uc001dxa.3	+	1	1855	c.1794G>C	c.(1792-1794)GTG>GTC	p.V598V		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	598	Cadherin 4.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GTGTCAGCGTGACTGTCCTGG	0.562		NA											4	77					0	0	0	0
C1orf162	128346	broad.mit.edu	37	1	112020686	112020686	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:112020686G>A	uc001ebe.2	+	6	469	c.409G>A	c.(409-411)GAG>AAG	p.E137K		NM_174896	NP_777556	Q8NEQ5	CA162_HUMAN	hypothetical protein LOC128346	137						integral to membrane				ovary(1)	1		all_cancers(81;0.00116)|all_epithelial(167;0.000761)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0236)|Colorectal(144;0.0286)|all cancers(265;0.0572)|Epithelial(280;0.0862)|COAD - Colon adenocarcinoma(174;0.112)|LUSC - Lung squamous cell carcinoma(189;0.134)		TCACTTGGCTGAGAACCATTC	0.428		NA											6	151					0	0	0	0
TSPAN2	10100	broad.mit.edu	37	1	115604779	115604779	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:115604779C>T	uc001eft.2	-	3	309	c.247G>A	c.(247-249)GAG>AAG	p.E83K		NM_005725	NP_005716	O60636	TSN2_HUMAN	tetraspan 2	83	Cytoplasmic (Potential).					integral to membrane					0	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		CATTGCGACTCCCGCATGGCT	0.453		NA											6	15					0	0	0	0
FLG	2312	broad.mit.edu	37	1	152284699	152284699	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:152284699C>A	uc001ezu.1	-	3	2699	c.2663G>T	c.(2662-2664)GGA>GTA	p.G888V	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	888	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTTCTGGATCCTGACTGCCC	0.562		NA							Ichthyosis				38	748					1.52e-26	1.83e-26	1	0
PTPRC	5788	broad.mit.edu	37	1	198701643	198701643	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:198701643C>T	uc001gur.1	+	20	2274	c.2094C>T	c.(2092-2094)AAC>AAT	p.N698N	PTPRC_uc001gus.1_Silent_p.N650N|PTPRC_uc001gut.1_Silent_p.N537N|PTPRC_uc009wzf.1_Silent_p.N586N|PTPRC_uc010ppg.1_Silent_p.N634N	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	698	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CTGAGATAAACGGAGATGCAG	0.318		NA											16	27					0	0	0	0
TTC13	79573	broad.mit.edu	37	1	231064751	231064751	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr1:231064751G>A	uc001huf.3	-	12	1420	c.1389C>T	c.(1387-1389)CAC>CAT	p.H463H	TTC13_uc009xfi.2_Silent_p.H410H|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Silent_p.H410H|TTC13_uc009xfk.1_Silent_p.H353H	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	463							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TTTTAGCCCAGTGGTCCTTAA	0.413		NA											72	106					0	0	0	0
ITIH5	80760	broad.mit.edu	37	10	7605143	7605143	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:7605143G>A	uc001ijq.2	-	14	2811	c.2732C>T	c.(2731-2733)GCC>GTC	p.A911V	ITIH5_uc001ijp.2_Missense_Mutation_p.A697V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	911					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CAGTTTGGCGGCATTGTTCCT	0.522		NA											4	216					0	0	0	0
NRP1	8829	broad.mit.edu	37	10	33552574	33552574	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:33552574C>T	uc001iwx.3	-	4	1181	c.658G>A	c.(658-660)GTT>ATT	p.V220I	NRP1_uc001iwv.3_Missense_Mutation_p.V220I|NRP1_uc009xlz.2_Missense_Mutation_p.V220I|NRP1_uc001iww.3_Missense_Mutation_p.V39I|NRP1_uc001iwy.3_Missense_Mutation_p.V220I|NRP1_uc001iwz.2_Missense_Mutation_p.V220I|NRP1_uc001ixa.2_Missense_Mutation_p.V220I|NRP1_uc001ixb.1_Missense_Mutation_p.V220I|NRP1_uc001ixc.1_Missense_Mutation_p.V220I	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	220	Extracellular (Potential).|CUB 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	TCATTCTTACCATCAGGGAAT	0.463		NA											9	44					0	0	0	0
CCDC109A	90550	broad.mit.edu	37	10	74645514	74645514	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:74645514C>T	uc001jtc.2	+	8	1011	c.990C>T	c.(988-990)GAC>GAT	p.D330D	CCDC109A_uc009xqr.2_Silent_p.D309D|CCDC109A_uc001jtd.2_Silent_p.D281D	NM_138357	NP_612366	Q8NE86	MCU_HUMAN	coiled-coil domain containing 109A	330	Potential.|Mitochondrial matrix (Potential).				elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)					CAGAAATGGACCTTAAGAGAC	0.393		NA											20	88					0	0	0	0
NEURL	9148	broad.mit.edu	37	10	105330708	105330708	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:105330708C>T	uc001kxh.2	+	2	575	c.165C>T	c.(163-165)AGC>AGT	p.S55S		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	55					nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TGCTGCCCAGCGGGGGGCTCC	0.652		NA											68	107					0	0	0	0
INPP5F	22876	broad.mit.edu	37	10	121586186	121586186	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:121586186C>G	uc001leo.2	+	20	2459	c.2293C>G	c.(2293-2295)CAA>GAA	p.Q765E	INPP5F_uc001lep.2_Missense_Mutation_p.Q155E	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	765							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TATCAGGTCTCAAAACCAAGG	0.363		NA											18	254					0	0	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133948575	133948575	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr10:133948575C>T	uc001lkx.3	+	4	880	c.880C>T	c.(880-882)CGC>TGC	p.R294C		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGATGCCCGGCGCTTCCAGCT	0.502		NA											23	38					0	0	0	0
AMPD3	272	broad.mit.edu	37	11	10516545	10516545	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:10516545C>G	uc001mio.1	+	8	1569	c.1234C>G	c.(1234-1236)CTG>GTG	p.L412V	AMPD3_uc010rbz.1_Missense_Mutation_p.L253V|AMPD3_uc001min.1_Missense_Mutation_p.L421V|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.L419V|AMPD3_uc009yfy.2_Missense_Mutation_p.L412V	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	412					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		TGAAAACTATCTGGGAGGAGA	0.537		NA											5	243					0	0	0	0
CAT	847	broad.mit.edu	37	11	34470887	34470887	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:34470887G>C	uc001mvm.2	+	2	298	c.215G>C	c.(214-216)AGA>ACA	p.R72T	CAT_uc009ykc.1_RNA	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	72					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	ATTCCTGAGAGAGTTGTGCAT	0.438		NA											13	162					0	0	0	0
RAG1	5896	broad.mit.edu	37	11	36596040	36596040	+	Missense_Mutation	SNP	C	C	T	rs104894289		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:36596040C>T	uc001mwu.3	+	2	1310	c.1186C>T	c.(1186-1188)CGC>TGC	p.R396C	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	396	NBD.		R -> C (in OS).|R -> L (in OS).|R -> H (in OS).		histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GGGCCGGCCCCGCCAACATCT	0.483		NA							Familial_Hemophagocytic_Lymphohistiocytosis				32	74					0	0	0	0
ANO1	55107	broad.mit.edu	37	11	70007338	70007338	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:70007338G>T	uc001opj.2	+	17	1955	c.1650G>T	c.(1648-1650)ATG>ATT	p.M550I	ANO1_uc001opk.1_Missense_Mutation_p.M492I|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.M259I	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	550	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CCTTGGCCATGAACTCCTCCC	0.582		NA											22	44					8.1e-08	9.22e-08	1	0
EED	8726	broad.mit.edu	37	11	85977185	85977185	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:85977185T>C	uc001pbp.2	+	8	1244	c.787T>C	c.(787-789)TGG>CGG	p.W263R	EED_uc010rtm.1_Missense_Mutation_p.W263R|EED_uc001pbq.2_Missense_Mutation_p.W263R|EED_uc001pbr.2_Missense_Mutation_p.W263R|EED_uc001pbs.2_Intron|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	263	Interaction with EZH2 (By similarity).|WD 4.|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				TCTTAAACTTTGGAGGATCAA	0.294		NA											5	76					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118375411	118375411	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:118375411C>G	uc001pta.2	+	27	8818	c.8795C>G	c.(8794-8796)TCT>TGT	p.S2932C	MLL_uc001ptb.2_Missense_Mutation_p.S2935C	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2932					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TCTGATCTGTCTGTCTTGACC	0.498		NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								3	108					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118376025	118376025	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:118376025C>G	uc001pta.2	+	27	9432	c.9409C>G	c.(9409-9411)CCA>GCA	p.P3137A	MLL_uc001ptb.2_Missense_Mutation_p.P3140A	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3137					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGGACTAAATCCAAGCTTGCC	0.468		NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								7	168					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118376147	118376147	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr11:118376147C>T	uc001pta.2	+	27	9554	c.9531C>T	c.(9529-9531)ATC>ATT	p.I3177I	MLL_uc001ptb.2_Silent_p.I3180I	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3177					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CACCAAACATCAGCAATCCTC	0.502		NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								4	128					0	0	0	0
COPS7A	50813	broad.mit.edu	37	12	6833912	6833912	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:6833912C>T	uc001qqj.2	+	2	329	c.90C>T	c.(88-90)CTC>CTT	p.L30L	COPS7A_uc009zex.2_RNA|COPS7A_uc001qqk.2_Silent_p.L30L|COPS7A_uc001qql.2_RNA|COPS7A_uc001qqh.2_Silent_p.L30L|COPS7A_uc001qqi.2_Silent_p.L30L|COPS7A_uc001qqm.2_RNA|COPS7A_uc001qqn.3_Silent_p.L30L|COPS7A_uc001qqo.2_Silent_p.L30L	NM_001164094	NP_001157566	Q9UBW8	CSN7A_HUMAN	COP9 complex subunit 7a	30					cullin deneddylation	cytoplasm|signalosome				ovary(1)	1						TGGCCACACTCATCCATCAGG	0.572		NA											6	99					0	0	0	0
KIAA1467	57613	broad.mit.edu	37	12	13224219	13224219	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:13224219C>T	uc001rbi.2	+	10	1436	c.1413C>T	c.(1411-1413)TAC>TAT	p.Y471Y	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	471						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TTTGGAGTTACCGTGCTCCGT	0.512		NA											6	132					0	0	0	0
SYT10	341359	broad.mit.edu	37	12	33560277	33560277	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:33560277C>T	uc001rll.1	-	3	821	c.524G>A	c.(523-525)CGA>CAA	p.R175Q	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	175	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CAGGTGTCTTCGGAAGGAACT	0.438		NA											5	166					0	0	0	0
ALG10	84920	broad.mit.edu	37	12	34179707	34179707	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:34179707C>G	uc001rlm.2	+	3	1598	c.1279C>G	c.(1279-1281)CTT>GTT	p.L427V		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	427	Extracellular (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				CATTTATAGGCTTAACATACC	0.338		NA											116	201					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49443899	49443899	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:49443899C>A	uc001rta.3	-	11	3472	c.3472G>T	c.(3472-3474)GAG>TAG	p.E1158*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1158	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCAGCTCCTCGGGGTCCAGG	0.602		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			47	87					2.08e-19	2.47e-19	1	0
TROAP	10024	broad.mit.edu	37	12	49719906	49719906	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:49719906C>T	uc001rtx.3	+	6	848	c.681C>T	c.(679-681)TTC>TTT	p.F227F	TROAP_uc009zlh.2_Silent_p.F227F|TROAP_uc001rty.2_5'Flank	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	227					cell adhesion	cytoplasm				ovary(1)	1						GCCCCAGTTTCCAGGAGCTAA	0.527		NA											8	243					0	0	0	0
PAN2	9924	broad.mit.edu	37	12	56717884	56717884	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:56717884C>T	uc001skx.2	-	13	2387	c.2014G>A	c.(2014-2016)GAG>AAG	p.E672K	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Missense_Mutation_p.E671K|PAN2_uc001sky.2_Missense_Mutation_p.E672K	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	672					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CGCACGGTCTCACTGCCACAG	0.542		NA											5	135					0	0	0	0
XPOT	11260	broad.mit.edu	37	12	64818958	64818958	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:64818958G>T	uc001ssb.2	+	13	1874	c.1448G>T	c.(1447-1449)CGA>CTA	p.R483L		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	483	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GATATGATGCGAACTGTAAGT	0.358		NA											7	215					1.77e-08	2.02e-08	1	0
GRIP1	23426	broad.mit.edu	37	12	66742828	66742828	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:66742828C>T	uc001stk.2	-	24	3443	c.3202G>A	c.(3202-3204)GAG>AAG	p.E1068K	GRIP1_uc001stj.2_Missense_Mutation_p.E835K	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	1120					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TCTCGTGTCTCCAAATTACCA	0.408		NA											29	332					0	0	0	0
ACSS3	79611	broad.mit.edu	37	12	81532986	81532986	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:81532986C>A	uc001szl.1	+	4	813	c.722C>A	c.(721-723)GCG>GAG	p.A241E	ACSS3_uc001szm.1_Missense_Mutation_p.A240E	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	241						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GTAGAAGAAGCGCTAAAAATA	0.353		NA											48	69					2.29e-23	2.73e-23	1	0
RASSF9	9182	broad.mit.edu	37	12	86199550	86199550	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:86199550T>C	uc001taf.1	-	2	577	c.238A>G	c.(238-240)ATA>GTA	p.I80V		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	80	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						CACTTCTCTATGATGCAGTAA	0.488		NA											71	87					0	0	0	0
SPPL3	121665	broad.mit.edu	37	12	121206202	121206202	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr12:121206202C>T	uc001tzd.2	-	8	1180	c.699G>A	c.(697-699)CGG>CGA	p.R233R	SPPL3_uc009zwz.2_Silent_p.R226R|SPPL3_uc001tzc.2_Silent_p.R63R	NM_139015	NP_620584	Q8TCT6	PSL4_HUMAN	signal peptide peptidase 3	234						integral to membrane	aspartic-type endopeptidase activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGTGGAGCTTCCGGGATAGAA	0.542		NA											6	237					0	0	0	0
HSPH1	10808	broad.mit.edu	37	13	31712628	31712628	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:31712628C>G	uc001utj.2	-	17	2684	c.2286G>C	c.(2284-2286)ATG>ATC	p.M762I	HSPH1_uc001utk.2_Missense_Mutation_p.M718I|HSPH1_uc010aaw.2_Missense_Mutation_p.M721I|HSPH1_uc001utl.2_Missense_Mutation_p.M764I|HSPH1_uc010tds.1_Missense_Mutation_p.M686I	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	762					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TGACATTATTCATCCATTCCA	0.358		NA											6	234					0	0	0	0
NBEA	26960	broad.mit.edu	37	13	36241642	36241642	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:36241642C>T	uc001uvb.2	+	56	8739	c.8533C>T	c.(8533-8535)CGA>TGA	p.R2845*	NBEA_uc010abi.2_Nonsense_Mutation_p.R1503*|NBEA_uc010tef.1_Nonsense_Mutation_p.R638*|NBEA_uc001uvd.2_Nonsense_Mutation_p.R423*	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2845						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGAACGAGGGCGATTCAGTAA	0.428		NA											28	185					0	0	0	0
SPG20	23111	broad.mit.edu	37	13	36909222	36909222	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:36909222C>T	uc001uvn.2	-	3	1016	c.746G>A	c.(745-747)CGA>CAA	p.R249Q	SPG20_uc010ten.1_Missense_Mutation_p.R249Q|SPG20_uc001uvm.2_Missense_Mutation_p.R249Q|SPG20_uc001uvo.2_Missense_Mutation_p.R249Q|SPG20_uc001uvq.2_Missense_Mutation_p.R249Q|SPG20_uc001uvp.2_Missense_Mutation_p.R249Q	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	249					cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CCTCACAATTCGAAGGTACCC	0.398		NA											4	164					0	0	0	0
ELF1	1997	broad.mit.edu	37	13	41533074	41533074	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr13:41533074G>C	uc001uxs.2	-	3	524	c.151C>G	c.(151-153)CTA>GTA	p.L51V	ELF1_uc010tfc.1_Missense_Mutation_p.L51V|ELF1_uc010acd.2_5'UTR	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	51					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		ACACAGGCTAGACCGGCATAA	0.453		NA											42	71					0	0	0	0
KIAA0391	9692	broad.mit.edu	37	14	35592848	35592848	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:35592848G>C	uc001wsy.1	+	2	757	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	KIAA0391_uc010tps.1_Missense_Mutation_p.E38Q|KIAA0391_uc001wsz.1_Missense_Mutation_p.E133Q|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Missense_Mutation_p.E133Q|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	133					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		AGATTTAAAAGAAAACACCGG	0.433		NA											3	102					0	0	0	0
PYGL	5836	broad.mit.edu	37	14	51398432	51398432	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:51398432C>T	uc001wyu.2	-	4	614	c.487G>A	c.(487-489)GAA>AAA	p.E163K	PYGL_uc010tqq.1_Missense_Mutation_p.E129K|PYGL_uc001wyv.2_5'UTR|PYGL_uc001wyw.3_Missense_Mutation_p.E163K	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	163					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	ATCCCATATTCATACCGAATG	0.438		NA											4	200					0	0	0	0
EIF2S1	1965	broad.mit.edu	37	14	67831504	67831504	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:67831504G>C	uc001xjg.2	+	2	161	c.20G>C	c.(19-21)AGA>ACA	p.R7T		NM_004094	NP_004085	P05198	IF2A_HUMAN	eukaryotic translation initiation factor 2,	7						cytosol|eukaryotic translation initiation factor 2 complex|polysome|stress granule	protein binding|ribosome binding|translation initiation factor activity			ovary(1)	1				all cancers(60;0.000683)|OV - Ovarian serous cystadenocarcinoma(108;0.00579)|BRCA - Breast invasive adenocarcinoma(234;0.00937)		ctaagttgtagattttatcaa	0.234		NA											3	151					0	0	0	0
ADAM20	8748	broad.mit.edu	37	14	70989722	70989722	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:70989722G>A	uc001xme.2	-	2	2148	c.1903C>T	c.(1903-1905)CAC>TAC	p.H635Y		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	585	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TCATTGAGGTGAAACTGCTGC	0.443		NA											6	139					0	0	0	0
NRXN3	9369	broad.mit.edu	37	14	80130147	80130147	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr14:80130147C>A	uc001xun.2	+	14	2843	c.2352C>A	c.(2350-2352)TTC>TTA	p.F784L	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.F152L|NRXN3_uc010asw.2_Missense_Mutation_p.F152L|NRXN3_uc001xur.3_Missense_Mutation_p.F152L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1157	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GAGTTGTCTTCAACATTGGCA	0.448		NA											21	29					1.28e-07	1.46e-07	1	0
UBE3A	7337	broad.mit.edu	37	15	25616832	25616832	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:25616832G>T	uc001zaq.2	-	4	498	c.498C>A	c.(496-498)AGC>AGA	p.S166R	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.S143R|UBE3A_uc001zas.2_Missense_Mutation_p.S163R|UBE3A_uc001zat.2_Missense_Mutation_p.S143R	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	166					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		CTTTCCGGAAGCTCTGTACCA	0.363		NA											70	106					7.07e-35	8.53e-35	1	0
EIF2AK4	440275	broad.mit.edu	37	15	40241351	40241351	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:40241351C>G	uc001zkm.1	+	4	445	c.395C>G	c.(394-396)TCA>TGA	p.S132*	EIF2AK4_uc001zkl.2_Nonsense_Mutation_p.S132*	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	132	RWD.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CACGTGCAGTCATTTCTCAGC	0.478		NA											21	320					0	0	0	0
MEGF11	84465	broad.mit.edu	37	15	66190400	66190400	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:66190400C>T	uc002apm.2	-	23	3148	c.3007G>A	c.(3007-3009)GGT>AGT	p.G1003S	MEGF11_uc002apl.2_Missense_Mutation_p.G928S	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11 precursor	1003						basolateral plasma membrane|integral to membrane				pancreas(1)	1						GAGTTATGACCGCAACCTTCT	0.458		NA											29	46					0	0	0	0
HCN4	10021	broad.mit.edu	37	15	73622066	73622066	+	Missense_Mutation	SNP	C	C	T	rs121908411		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:73622066C>T	uc002avp.2	-	4	2432	c.1438G>A	c.(1438-1440)GGC>AGC	p.G480S		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	480					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CGCCCGTAGCCGATGCACAGC	0.622		NA											34	35					0	0	0	0
MAN2C1	4123	broad.mit.edu	37	15	75655014	75655014	+	Missense_Mutation	SNP	C	C	T	rs149884810		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:75655014C>T	uc002baf.2	-	7	883	c.866G>A	c.(865-867)CGG>CAG	p.R289Q	MAN2C1_uc002bag.2_Missense_Mutation_p.R289Q|MAN2C1_uc002bah.2_Missense_Mutation_p.R289Q|MAN2C1_uc010bkk.2_Intron|MAN2C1_uc010umi.1_Missense_Mutation_p.R71Q|MAN2C1_uc010umj.1_RNA	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	289					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						CTCAGGGTTCCGCTCCATGAG	0.622		NA											12	54					0	0	0	0
NRG4	145957	broad.mit.edu	37	15	76254257	76254257	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:76254257T>A	uc002bbo.2	-	4	347	c.163A>T	c.(163-165)ATC>TTC	p.I55F	NRG4_uc010bkm.1_RNA|NRG4_uc002bbn.2_RNA|NRG4_uc010bkn.2_RNA|NRG4_uc010bko.2_RNA|NRG4_uc002bbp.2_RNA	NM_138573	NP_612640	Q8WWG1	NRG4_HUMAN	neuregulin 4	55	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	growth factor activity				0						TTAGTTTGGATGCTGGAGCCT	0.388		NA											80	108					0	0	0	0
MAN2A2	4122	broad.mit.edu	37	15	91454654	91454654	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr15:91454654C>T	uc010bnz.2	+	14	2098	c.1983C>T	c.(1981-1983)TTC>TTT	p.F661F	MAN2A2_uc002bqc.2_Silent_p.F661F|MAN2A2_uc010uql.1_Silent_p.F323F|MAN2A2_uc010uqm.1_Silent_p.F240F|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	661	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			AGGAGCGATTCAGCATGGTGT	0.627		NA											36	102					0	0	0	0
DNASE1L2	1775	broad.mit.edu	37	16	2288404	2288404	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:2288404C>T	uc002cpo.2	+	6	1279	c.885C>T	c.(883-885)CTC>CTT	p.L295L	DNASE1L2_uc002cpn.2_Silent_p.L274L|DNASE1L2_uc002cpp.2_Silent_p.L295L|DNASE1L2_uc002cpq.2_Silent_p.L295L	NM_001374	NP_001365	Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2 precursor	295					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding				0						AGGTGACCCTCAAGTTCCACC	0.637		NA											5	153					0	0	0	0
ACSM2A	123876	broad.mit.edu	37	16	20489931	20489931	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:20489931G>A	uc010bwe.2	+	11	1452	c.1213G>A	c.(1213-1215)GGC>AGC	p.G405S	ACSM2A_uc010vax.1_Missense_Mutation_p.G326S|ACSM2A_uc002dhf.3_Missense_Mutation_p.G405S|ACSM2A_uc002dhg.3_Missense_Mutation_p.G405S|ACSM2A_uc010vay.1_Missense_Mutation_p.G326S|ACSM2A_uc002dhh.3_Missense_Mutation_p.G35S	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	405					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCTGCCCCCCGGCACAGAAGG	0.512		NA											30	81					0	0	0	0
ACSM3	6296	broad.mit.edu	37	16	20808211	20808211	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:20808211G>C	uc002dhr.2	+	14	1865	c.1678G>C	c.(1678-1680)GAA>CAA	p.E560Q	ERI2_uc002dht.3_3'UTR|ACSM3_uc010vba.1_Missense_Mutation_p.E589Q|ERI2_uc002dhs.2_Intron|ERI2_uc010vbb.1_3'UTR|ERI2_uc010bwh.2_3'UTR|ERI2_uc010vbc.1_3'UTR|ERI2_uc002dhu.1_3'UTR	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	560					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						CCAACAGGTAGAATTTATTCA	0.323		NA											3	91					0	0	0	0
POLR3E	55718	broad.mit.edu	37	16	22344979	22344979	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:22344979C>T	uc002dkk.2	+	21	2241	c.2085C>T	c.(2083-2085)AGC>AGT	p.S695S	POLR3E_uc002dkm.2_Silent_p.S659S|POLR3E_uc010vbr.1_Silent_p.S674S|POLR3E_uc002dkl.2_Silent_p.S653S|POLR3E_uc010vbs.1_Silent_p.S659S|POLR3E_uc010vbt.1_Silent_p.S639S	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	695					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		GCTGTGTAAGCTATGGTGGCA	0.433		NA											33	58					0	0	0	0
CLN3	1201	broad.mit.edu	37	16	28498849	28498849	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:28498849C>T	uc002dpo.2	-	6	711	c.388G>A	c.(388-390)GTC>ATC	p.V130I	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.V52I|CLN3_uc010vcu.1_Missense_Mutation_p.V30I|CLN3_uc002dpn.2_Missense_Mutation_p.R103H|CLN3_uc002dpm.2_Missense_Mutation_p.V76I|CLN3_uc010vcv.1_Missense_Mutation_p.V106I|CLN3_uc010byd.2_Missense_Mutation_p.V130I|CLN3_uc002dpp.2_Missense_Mutation_p.V130I|CLN3_uc002dpt.1_Missense_Mutation_p.V30I|CLN3_uc002dpq.1_Missense_Mutation_p.V130I|CLN3_uc010bye.1_Missense_Mutation_p.V130I|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.R75H|CLN3_uc002dpu.1_Missense_Mutation_p.V76I|CLN3_uc002dpw.1_Missense_Mutation_p.R49H|CLN3_uc010vcw.1_Missense_Mutation_p.V76I|CLN3_uc002dqa.2_Missense_Mutation_p.V181I|CLN3_uc010vcx.1_Missense_Mutation_p.V30I|CLN3_uc002dpx.1_Missense_Mutation_p.R79H|CLN3_uc002dpy.1_Missense_Mutation_p.R46H|CLN3_uc002dpz.1_RNA	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	130	Helical; (Potential).				amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						ATCCCACTGACGAGAACCCGG	0.587		NA											18	31					0	0	0	0
CDH5	1003	broad.mit.edu	37	16	66430060	66430060	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:66430060C>T	uc002eom.3	+	8	1472	c.1316C>T	c.(1315-1317)CCC>CTC	p.P439L		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	439	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GAAGTCTACCCCTGGTATAAC	0.498		NA											39	78					0	0	0	0
NFATC3	4775	broad.mit.edu	37	16	68224779	68224779	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:68224779C>T	uc002evo.1	+	9	2417	c.2207C>T	c.(2206-2208)TCA>TTA	p.S736L	NFATC3_uc010vkl.1_Missense_Mutation_p.S257L|NFATC3_uc010vkm.1_Missense_Mutation_p.S257L|NFATC3_uc010vkn.1_Missense_Mutation_p.S257L|NFATC3_uc010vko.1_Missense_Mutation_p.S257L|NFATC3_uc010vkp.1_Missense_Mutation_p.S257L|NFATC3_uc010vkq.1_Missense_Mutation_p.S257L|NFATC3_uc002evl.2_Missense_Mutation_p.S257L|NFATC3_uc002evk.2_Missense_Mutation_p.S736L|NFATC3_uc002evm.1_Missense_Mutation_p.S736L|NFATC3_uc002evn.1_Missense_Mutation_p.S736L|NFATC3_uc010vkr.1_Missense_Mutation_p.S257L|NFATC3_uc010vks.1_Missense_Mutation_p.S257L|NFATC3_uc010vkt.1_Missense_Mutation_p.S257L|NFATC3_uc010vku.1_Missense_Mutation_p.S257L|NFATC3_uc010vkv.1_Missense_Mutation_p.S257L|NFATC3_uc010vkw.1_Missense_Mutation_p.S257L|NFATC3_uc010vkx.1_Missense_Mutation_p.S257L|NFATC3_uc010vky.1_Missense_Mutation_p.S257L|NFATC3_uc010vkz.1_Missense_Mutation_p.S257L|NFATC3_uc010vla.1_Missense_Mutation_p.S257L|NFATC3_uc010vlb.1_Missense_Mutation_p.S257L|NFATC3_uc010vlc.1_Missense_Mutation_p.S257L	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	736					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TCAGGGTGTTCACATGACAGT	0.478		NA											9	137					0	0	0	0
CHST6	4166	broad.mit.edu	37	16	75512968	75512968	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:75512968G>A	uc002fef.2	-	3	939	c.759C>T	c.(757-759)GCC>GCT	p.A253A	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.A253A	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	253	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						TGGCGGCCTCGGCGATGCGTA	0.716		NA											22	33					0	0	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77465305	77465305	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:77465305C>G	uc002ffc.3	-	3	801	c.382G>C	c.(382-384)GGA>CGA	p.G128R	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	128					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CCATCTTTTCCAAGTACCTGG	0.473		NA											4	205					0	0	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064472	78064472	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr16:78064472G>T	uc002ffh.3	+	3	409	c.328G>T	c.(328-330)GAA>TAA	p.E110*		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	110	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						GAACTCCGACGAAATCAACGC	0.478		NA											47	84					8.21e-20	9.75e-20	1	0
PLD2	5338	broad.mit.edu	37	17	4713248	4713248	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:4713248G>A	uc002fzc.2	+	9	885	c.784G>A	c.(784-786)GAC>AAC	p.D262N	PLD2_uc010vsj.1_Missense_Mutation_p.D119N|PLD2_uc002fzd.2_Missense_Mutation_p.D262N	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	262	PH.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	TCAGCTCTTTGACCCTGGCTT	0.592		NA											5	148					0	0	0	0
NLRP1	22861	broad.mit.edu	37	17	5418344	5418344	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:5418344C>A	uc002gci.2	-	17	4707	c.4152G>T	c.(4150-4152)CAG>CAT	p.Q1384H	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Missense_Mutation_p.Q1340H|NLRP1_uc002gcj.2_Missense_Mutation_p.Q1354H|NLRP1_uc002gcl.2_Missense_Mutation_p.Q1310H|NLRP1_uc002gch.3_Missense_Mutation_p.Q1340H	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1384	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCTCTCGATACTGGTCCACAA	0.582		NA											21	37					8.1e-08	9.22e-08	1	0
C17orf75	64149	broad.mit.edu	37	17	30668260	30668260	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:30668260C>T	uc002hhg.2	-	2	215	c.184G>A	c.(184-186)GGC>AGC	p.G62S		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	62					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			GCATTTGTGCCACTTGGGCTT	0.463		NA											8	241					0	0	0	0
RFFL	117584	broad.mit.edu	37	17	33343399	33343399	+	Silent	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:33343399G>C	uc002hin.1	-	5	1049	c.876C>G	c.(874-876)CTC>CTG	p.L292L	RFFL_uc002hiq.2_Silent_p.L209L|RFFL_uc002him.1_Silent_p.L292L|RFFL_uc010cti.1_Silent_p.L298L|RFFL_uc002hip.1_Silent_p.L264L|RFFL_uc002hio.1_Silent_p.L292L	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	292					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CCAGGTGCTGGAGTCCTTTCT	0.502		NA											3	209					0	0	0	0
RASL10B	91608	broad.mit.edu	37	17	34068186	34068186	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:34068186C>T	uc002hju.2	+	4	840	c.474C>T	c.(472-474)TGC>TGT	p.C158C		NM_033315	NP_201572	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B precursor	158	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			lung(2)|breast(2)	4				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACGTGGAATGCTCGGCCAAGT	0.647		NA											22	45					0	0	0	0
NSF	4905	broad.mit.edu	37	17	44770362	44770362	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:44770362C>G	uc002iku.2	+	10	1143	c.1039C>G	c.(1039-1041)CAT>GAT	p.H347D	NSF_uc010wke.1_Missense_Mutation_p.H253D|NSF_uc010wkf.1_Missense_Mutation_p.H253D|NSF_uc010wkg.1_Missense_Mutation_p.H342D	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	347					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		CACGGGAGTTCATGACACTGT	0.423		NA											3	106					0	0	0	0
TRIM37	4591	broad.mit.edu	37	17	57165711	57165711	+	Silent	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:57165711T>C	uc002iwy.3	-	4	666	c.222A>G	c.(220-222)CAA>CAG	p.Q74Q	TRIM37_uc002iwz.3_Silent_p.Q74Q|TRIM37_uc002ixa.3_5'UTR|TRIM37_uc010woc.1_Silent_p.Q40Q	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	74						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TATCAAGCTGTTGTGTTACTT	0.383		NA							Mulibrey_Nanism				22	29					0	0	0	0
GNA13	10672	broad.mit.edu	37	17	63010430	63010430	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:63010430C>A	uc002jfc.2	-	4	1288	c.1079G>T	c.(1078-1080)CGT>CTT	p.R360L	GNA13_uc010wqh.1_Missense_Mutation_p.R265L	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	360					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						CTTCACGTCACGGAAAACAAG	0.443		NA											3	97					0.004672	0.00500704	1	0
SSTR2	6752	broad.mit.edu	37	17	71166310	71166310	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr17:71166310C>T	uc002jje.2	+	2	1212	c.852C>T	c.(850-852)ATC>ATT	p.I284I		NM_001050	NP_001041	P30874	SSR2_HUMAN	somatostatin receptor 2	284	Extracellular (Potential).				digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity				0			LUSC - Lung squamous cell carcinoma(166;0.197)			CCATGGCCATCAGCCCCACCC	0.507		NA											5	199					0	0	0	0
NOL4	8715	broad.mit.edu	37	18	31538327	31538327	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:31538327C>T	uc010dmi.2	-	7	1341	c.1112G>A	c.(1111-1113)CGA>CAA	p.R371Q	NOL4_uc010xbs.1_Missense_Mutation_p.R86Q|NOL4_uc002kxr.3_Missense_Mutation_p.R207Q|NOL4_uc010xbt.1_Missense_Mutation_p.R297Q|NOL4_uc010dmh.2_Missense_Mutation_p.R297Q|NOL4_uc010xbu.1_Missense_Mutation_p.R371Q|NOL4_uc002kxt.3_Missense_Mutation_p.R371Q|NOL4_uc010xbv.1_Missense_Mutation_p.R120Q|NOL4_uc010xbw.1_Missense_Mutation_p.R257Q	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	371						nucleolus	RNA binding			ovary(3)	3						CTCAGCTCCTCGGTCTACACT	0.453		NA											11	351					0	0	0	0
MBD1	4152	broad.mit.edu	37	18	47799971	47799971	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:47799971G>A	uc010dow.1	-	12	1846	c.1409C>T	c.(1408-1410)CCG>CTG	p.P470L	MBD1_uc002lef.2_Missense_Mutation_p.P221L|MBD1_uc002leg.2_Missense_Mutation_p.P420L|MBD1_uc010xdi.1_Missense_Mutation_p.P521L|MBD1_uc002leh.3_Missense_Mutation_p.P414L|MBD1_uc002len.2_Missense_Mutation_p.P470L|MBD1_uc002lei.3_Missense_Mutation_p.P470L|MBD1_uc002lej.3_Missense_Mutation_p.P414L|MBD1_uc002lek.3_Missense_Mutation_p.P421L|MBD1_uc002lel.3_Missense_Mutation_p.P447L|MBD1_uc002lem.3_Missense_Mutation_p.P470L|MBD1_uc010xdj.1_Missense_Mutation_p.P414L|MBD1_uc010xdk.1_Missense_Mutation_p.P495L|MBD1_uc010dox.1_Missense_Mutation_p.P447L|MBD1_uc002leo.2_Missense_Mutation_p.P470L	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	470					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AACAGGGCCCGGCACCTGCAC	0.637		NA											28	32					0	0	0	0
CXXC1	30827	broad.mit.edu	37	18	47812188	47812188	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:47812188C>T	uc002leq.3	-	5	1303	c.570G>A	c.(568-570)ATG>ATA	p.M190I	CXXC1_uc002lep.3_Missense_Mutation_p.M47I|CXXC1_uc002ler.3_Missense_Mutation_p.M190I|CXXC1_uc010doy.2_Missense_Mutation_p.M190I|CXXC1_uc002les.2_Missense_Mutation_p.M190I	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	190	CXXC-type.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CGAACTTCTTCATGTCCCGAC	0.577		NA											61	104					0	0	0	0
SALL3	27164	broad.mit.edu	37	18	76754440	76754440	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:76754440G>A	uc002lmt.2	+	2	2449	c.2449G>A	c.(2449-2451)GAC>AAC	p.D817N	SALL3_uc010dra.2_Missense_Mutation_p.D424N	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	817					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGCGGCCACCGACCCGGCCAA	0.642		NA											14	12					0	0	0	0
C18orf22	79863	broad.mit.edu	37	18	77806103	77806103	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:77806103G>A	uc002lns.2	+	7	1118	c.980G>A	c.(979-981)AGA>AAA	p.R327K	C18orf22_uc010drh.2_3'UTR|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_Missense_Mutation_p.R160K|uc002lnu.2_5'Flank	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	327					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GAGGCAGAGAGAGGAGGTGGC	0.582		NA											3	48					0	0	0	0
C18orf22	79863	broad.mit.edu	37	18	77806105	77806105	+	Missense_Mutation	SNP	G	G	A	rs138311529		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr18:77806105G>A	uc002lns.2	+	7	1120	c.982G>A	c.(982-984)GGA>AGA	p.G328R	C18orf22_uc010drh.2_3'UTR|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_Missense_Mutation_p.G161R|uc002lnu.2_5'Flank	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	328					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GGCAGAGAGAGGAGGTGGCAG	0.587		NA											3	49					0	0	0	0
DOT1L	84444	broad.mit.edu	37	19	2213555	2213555	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:2213555C>T	uc002lvb.3	+	17	1611	c.1575C>T	c.(1573-1575)CTC>CTT	p.L525L	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_RNA|DOT1L_uc002lve.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	525						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCCCAGCTCCTGGGTGCGG	0.617		NA											24	21					0	0	0	0
ZNF136	7695	broad.mit.edu	37	19	12296616	12296616	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:12296616A>G	uc002mti.2	+	2	120	c.20A>G	c.(19-21)GAG>GGG	p.E7G	ZNF136_uc010xmh.1_Intron	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	7	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GTGGCTTTTGAGGATGTAGAT	0.483		NA											3	99					0	0	0	0
F2RL3	9002	broad.mit.edu	37	19	17001171	17001171	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:17001171C>A	uc002nfa.2	+	2	1072	c.897C>A	c.(895-897)AGC>AGA	p.S299R		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	299	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						TCGTGCCCAGCAACCTGCTGC	0.701		NA											9	8					0.000274275	0.000298704	1	0
MAP1S	55201	broad.mit.edu	37	19	17845129	17845129	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:17845129C>T	uc002nhe.1	+	7	3081	c.3072C>T	c.(3070-3072)TAC>TAT	p.Y1024Y	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Silent_p.Y272Y|MAP1S_uc010xpv.1_Silent_p.Y998Y	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	1024	Necessary for association with actin (By similarity).|Necessary for interaction with RASSF1 isoform A and isoform C.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						ATACGTGGTACGCAGAGACGC	0.657		NA											21	52					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22363197	22363197	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:22363197C>T	uc002nqs.1	-	3	1640	c.1322G>A	c.(1321-1323)AGA>AAA	p.R441K		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	441	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGCATGAATTCTCTTGTGTTC	0.438		NA											90	159					0	0	0	0
ZFP14	57677	broad.mit.edu	37	19	36853022	36853022	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:36853022A>T	uc002odx.1	-	2	221	c.128T>A	c.(127-129)ATT>AAT	p.I43N	ZFP14_uc010xtd.1_Missense_Mutation_p.I43N|ZFP14_uc010eex.1_Missense_Mutation_p.I43N	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	43	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					ACCTAGTGAAATGAAGTTGCT	0.378		NA											48	73					0	0	0	0
ZNF569	148266	broad.mit.edu	37	19	37903739	37903739	+	Silent	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:37903739T>C	uc002ogi.2	-	6	2379	c.1821A>G	c.(1819-1821)GAA>GAG	p.E607E	ZNF569_uc002ogh.2_Silent_p.E448E|ZNF569_uc002ogj.2_Silent_p.E631E	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	607	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTTATTACATTCATAGGGTT	0.413		NA											83	149					0	0	0	0
LGALS4	3960	broad.mit.edu	37	19	39297125	39297125	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:39297125G>A	uc002ojg.2	-	4	664	c.450C>T	c.(448-450)ATC>ATT	p.I150I	LGALS4_uc010xuj.1_Silent_p.I150I	NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	150	Galectin 1.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GCTGGCCTCCGATGAAGTTGA	0.488		NA											7	137					0	0	0	0
PSG7	5676	broad.mit.edu	37	19	43439678	43439678	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:43439678G>C	uc002ovl.3	-	3	410	c.308C>G	c.(307-309)TCC>TGC	p.S103C	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	103	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGATGCATTGGAATATACTGT	0.428		NA											6	611					0	0	0	0
QPCTL	54814	broad.mit.edu	37	19	46206184	46206184	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:46206184C>T	uc010xxr.1	+	7	1247	c.1026C>T	c.(1024-1026)ATC>ATT	p.I342I	QPCTL_uc010ekn.2_Silent_p.I248I	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	342					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		TCCATCTCATCTCCACGCCCT	0.597		NA											30	226					0	0	0	0
ZNF468	90333	broad.mit.edu	37	19	53344519	53344519	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:53344519G>C	uc002qaf.2	-	4	1179	c.1028C>G	c.(1027-1029)GCA>GGA	p.A343G	ZNF468_uc002qae.2_Missense_Mutation_p.A290G	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	343	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		AGTATGTTTTGCCAGATATGA	0.378		NA											5	210					0	0	0	0
LILRA3	11026	broad.mit.edu	37	19	54803659	54803659	+	Silent	SNP	C	C	T	rs138979811	byFrequency	TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:54803659C>T	uc002qfd.2	-	3	230	c.165G>A	c.(163-165)ACG>ACA	p.T55T	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.T55T	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	55	Ig-like C2-type 1.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTACTCCTGCGTCTCCAGGC	0.567		NA											11	97					0	0	0	0
NLRP2	55655	broad.mit.edu	37	19	55494891	55494891	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:55494891C>T	uc002qij.2	+	6	1911	c.1825C>T	c.(1825-1827)CTG>TTG	p.L609L	NLRP2_uc010yfp.1_Silent_p.L586L|NLRP2_uc010esn.2_Silent_p.L585L|NLRP2_uc010eso.2_Silent_p.L606L|NLRP2_uc010esp.2_Silent_p.L587L	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	609					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CCTCGGCTGTCTGTACGAGTC	0.507		NA											3	33					0	0	0	0
ZNF471	57573	broad.mit.edu	37	19	57037187	57037187	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:57037187C>T	uc002qnh.2	+	5	1884	c.1751C>T	c.(1750-1752)TCA>TTA	p.S584L		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	584	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AGTGATAGCTCATCCTGTGCT	0.413		NA											16	105					0	0	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58189827	58189827	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:58189827G>T	uc002qpu.2	+	5	1553	c.856G>T	c.(856-858)GCC>TCC	p.A286S		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	286					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCTGAGTCTGCCCTTACCCA	0.483		NA											6	145					0.00116845	0.00125725	1	0
ZNF544	27300	broad.mit.edu	37	19	58772699	58772699	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr19:58772699G>A	uc010euo.2	+	7	1201	c.727G>A	c.(727-729)GAA>AAA	p.E243K	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.E215K|ZNF544_uc010yhy.1_Missense_Mutation_p.E215K|ZNF544_uc002qrt.3_Missense_Mutation_p.E101K|ZNF544_uc002qru.3_Missense_Mutation_p.E101K|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AAACCCTTATGAATATATTGT	0.388		NA											9	207					0	0	0	0
SLC3A1	6519	broad.mit.edu	37	2	44547602	44547602	+	Missense_Mutation	SNP	G	G	A	rs146303355		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:44547602G>A	uc002ruc.3	+	10	1960	c.1882G>A	c.(1882-1884)GAC>AAC	p.D628N	PREPL_uc002ruf.2_3'UTR|PREPL_uc002rug.2_3'UTR|PREPL_uc002ruh.2_3'UTR|PREPL_uc010fax.2_3'UTR|PREPL_uc002rui.3_3'UTR|PREPL_uc002ruj.1_3'UTR|PREPL_uc002ruk.1_3'UTR|SLC3A1_uc002rud.3_Missense_Mutation_p.D350N|SLC3A1_uc002rue.3_Missense_Mutation_p.D248N	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	628	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	CAATTCTGCCGACAAAGGCAG	0.413		NA											4	131					0	0	0	0
EPAS1	2034	broad.mit.edu	37	2	46583923	46583923	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:46583923C>T	uc002ruv.2	+	4	918	c.430C>T	c.(430-432)CGT>TGT	p.R144C		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	144	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			TGAGGAGATTCGTGAGAACCT	0.448		NA											46	63					0	0	0	0
USP34	9736	broad.mit.edu	37	2	61597495	61597495	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:61597495C>T	uc002sbe.2	-	10	1234	c.1212G>A	c.(1210-1212)CTG>CTA	p.L404L		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	404					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GTTGAGTACTCAGTCGCCCTT	0.244		NA											6	198					0	0	0	0
ACTG2	72	broad.mit.edu	37	2	74129548	74129548	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:74129548G>T	uc002sjw.2	+	3	310	c.188G>T	c.(187-189)CGA>CTA	p.R63L	ACTG2_uc010fex.1_Missense_Mutation_p.R63L|ACTG2_uc010fey.2_Missense_Mutation_p.R63L|ACTG2_uc010yrn.1_Intron	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	63					muscle contraction	cytoskeleton|cytosol	ATP binding				0						CAGAGCAAGCGAGGGATCCTA	0.483		NA											30	46					2.44e-19	2.88e-19	1	0
TUBA3D	113457	broad.mit.edu	37	2	132235898	132235898	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:132235898G>C	uc002tsu.3	+	2	272	c.165G>C	c.(163-165)GAG>GAC	p.E55D		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	55					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TCTTCAGTGAGACTGGAGCTG	0.557		NA											18	58					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165986673	165986673	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:165986673C>T	uc002ucx.2	-	17	3191	c.2699G>A	c.(2698-2700)GGC>GAC	p.G900D	SCN3A_uc002ucy.2_Missense_Mutation_p.G851D|SCN3A_uc002ucz.2_Missense_Mutation_p.G851D|SCN3A_uc002uda.1_Missense_Mutation_p.G720D|SCN3A_uc002udb.1_Missense_Mutation_p.G720D	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	900	Helical; Name=S5 of repeat II; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GAGCTGCATGCCGACCACAGC	0.463		NA											4	272					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196673458	196673458	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:196673458C>T	uc002utj.3	-	53	10132	c.10031G>A	c.(10030-10032)CGT>CAT	p.R3344H		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3344					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAACTCTCTACGAATGGTTTT	0.373		NA											4	163					0	0	0	0
TUBA4A	7277	broad.mit.edu	37	2	220116386	220116386	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:220116386G>A	uc002vkt.1	-	3	334	c.276C>T	c.(274-276)CTC>CTT	p.L92L	TUBA4A_uc010zkz.1_Silent_p.L77L|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	92					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCCAGTGATGAGCTGCTCTG	0.547		NA											12	68					0	0	0	0
SPEG	10290	broad.mit.edu	37	2	220338272	220338272	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:220338272C>T	uc010fwg.2	+	17	4194	c.4194C>T	c.(4192-4194)ATC>ATT	p.I1398I		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1398	Ig-like 7.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AACCAGACATCGTGTATGTGG	0.498		NA											21	202					0	0	0	0
SLC4A3	6508	broad.mit.edu	37	2	220501431	220501431	+	Silent	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:220501431C>G	uc002vmp.3	+	16	2639	c.2370C>G	c.(2368-2370)CTC>CTG	p.L790L	SLC4A3_uc002vmo.3_Silent_p.L817L|SLC4A3_uc010fwm.2_Silent_p.L340L|SLC4A3_uc010fwn.1_Silent_p.L299L	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	790	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGAGTACCTCACTGGCCGGG	0.642		NA											4	144					0	0	0	0
FARSB	10056	broad.mit.edu	37	2	223499180	223499180	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr2:223499180G>A	uc002vne.1	-	6	571	c.536C>T	c.(535-537)TCA>TTA	p.S179L	FARSB_uc010zlq.1_Missense_Mutation_p.S199L|FARSB_uc002vnf.1_Missense_Mutation_p.S80L	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	179					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	TTTGATATCTGAAGGACGCTT	0.398		NA											4	84					0	0	0	0
RALGAPB	57148	broad.mit.edu	37	20	37150172	37150172	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr20:37150172C>T	uc002xiw.2	+	10	1707	c.1450C>T	c.(1450-1452)CGG>TGG	p.R484W	RALGAPB_uc010zvz.1_Intron|RALGAPB_uc002xix.2_Missense_Mutation_p.R484W|RALGAPB_uc002xiy.1_Missense_Mutation_p.R484W|RALGAPB_uc002xiz.2_Missense_Mutation_p.R262W|RALGAPB_uc002xja.1_Missense_Mutation_p.R211W	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	484					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						GGAGTTTCGACGGAAAGGGTC	0.453		NA											5	238					0	0	0	0
MYT1	4661	broad.mit.edu	37	20	62839236	62839236	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr20:62839236C>T	uc002yii.2	+	7	1051	c.687C>T	c.(685-687)ACC>ACT	p.T229T	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	229	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AAGTCACCACCGAGCGCTCCC	0.572		NA											11	77					0	0	0	0
GCFC1	94104	broad.mit.edu	37	21	34116017	34116017	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:34116017C>T	uc002yqn.2	-	14	2429	c.2239G>A	c.(2239-2241)GAT>AAT	p.D747N	GCFC1_uc002yql.2_Missense_Mutation_p.D256N|GCFC1_uc002yqm.2_Missense_Mutation_p.D241N|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.D747N	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	747						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						ATAAATACATCATCATCTAAA	0.289		NA											11	24					0	0	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074247	46074247	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:46074247G>A	uc002zfs.1	-	1	330	c.285C>T	c.(283-285)TTC>TTT	p.F95F	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198698	NP_941971	P60329	KR124_HUMAN	keratin associated protein 12-4	95	15 X 5 AA approximate repeats.|14.					keratin filament				ovary(1)	1						GGGTGGGGCAGAAGGGCTGGC	0.632		NA											4	100					0	0	0	0
POFUT2	23275	broad.mit.edu	37	21	46702265	46702265	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:46702265G>A	uc002zhc.2	-	4	662	c.637C>T	c.(637-639)CGG>TGG	p.R213W	POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_Missense_Mutation_p.R213W|POFUT2_uc011afp.1_Missense_Mutation_p.R213W	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	213					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		GGCACTCACCGGGCTGATGTG	0.667		NA											41	51					0	0	0	0
PCNT	5116	broad.mit.edu	37	21	47783638	47783638	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr21:47783638C>G	uc002zji.3	+	14	2505	c.2398C>G	c.(2398-2400)CAG>GAG	p.Q800E	PCNT_uc002zjj.2_Missense_Mutation_p.Q682E	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	800	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GAGGCAGCTTCAGGACCAACA	0.522		NA											3	96					0	0	0	0
CECR1	51816	broad.mit.edu	37	22	17688100	17688100	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:17688100G>A	uc002zmk.1	-	2	615	c.403C>T	c.(403-405)CAC>TAC	p.H135Y	CECR1_uc010gqu.1_Missense_Mutation_p.H135Y|CECR1_uc011agi.1_Missense_Mutation_p.H93Y|CECR1_uc011agj.1_Missense_Mutation_p.H93Y	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	135	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				AAACAGATGTGGCAGTGAGGC	0.522		NA											48	89					0	0	0	0
SERPIND1	3053	broad.mit.edu	37	22	21138321	21138321	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:21138321G>A	uc002ztb.1	+	3	1018	c.951G>A	c.(949-951)GAG>GAA	p.E317E	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.E345E	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	317					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	GGCTGAATGAGAGAGAGGTAG	0.502		NA									OREG0026325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	270					0	0	0	0
SFI1	9814	broad.mit.edu	37	22	32007798	32007798	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:32007798G>A	uc003ale.2	+	24	2855	c.2462G>A	c.(2461-2463)CGG>CAG	p.R821Q	SFI1_uc003alf.2_Missense_Mutation_p.R790Q|SFI1_uc003alg.2_Missense_Mutation_p.R739Q|SFI1_uc011alp.1_Missense_Mutation_p.R727Q|SFI1_uc011alq.1_Missense_Mutation_p.R766Q|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_5'Flank|SFI1_uc003alj.2_5'Flank	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	821					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						AGACTCAGCCGGACCTGCTTC	0.617		NA											21	31					0	0	0	0
PACSIN2	11252	broad.mit.edu	37	22	43275154	43275154	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr22:43275154G>A	uc010gzg.2	-	8	1150	c.928C>T	c.(928-930)CGA>TGA	p.R310*	PACSIN2_uc003bdg.3_Nonsense_Mutation_p.R310*|PACSIN2_uc003bde.3_Nonsense_Mutation_p.R310*|PACSIN2_uc003bdf.3_Nonsense_Mutation_p.R310*	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	310					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				CTGAGGGTTCGATTCAGGTCT	0.592		NA											5	101					0	0	0	0
SACM1L	22908	broad.mit.edu	37	3	45744942	45744942	+	Silent	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:45744942T>C	uc003cos.2	+	2	249	c.45T>C	c.(43-45)CCT>CCC	p.P15P	SACM1L_uc011bag.1_5'UTR|SACM1L_uc011bah.1_5'UTR	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	15						Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		ATATCACACCTGAAAAATTTT	0.348		NA											3	125					0	0	0	0
CCR2	729230	broad.mit.edu	37	3	46399948	46399948	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:46399948G>A	uc003cpn.3	+	2	1415	c.930G>A	c.(928-930)GAG>GAA	p.E310E	CCR2_uc003cpm.3_Silent_p.E310E	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	310	Cytoplasmic (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		TCGTTGGGGAGAAGTTCAGAA	0.502		NA											15	149					0	0	0	0
DNAH1	25981	broad.mit.edu	37	3	52404531	52404531	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:52404531C>T	uc011bef.1	+	40	6558	c.6297C>T	c.(6295-6297)ATC>ATT	p.I2099I		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2099					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGAGTCGCATCGTAGAGTTGA	0.557		NA											12	27					0	0	0	0
TMEM110	375346	broad.mit.edu	37	3	52867433	52867433	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:52867433C>T	uc003dgc.3	-	10	1107	c.1026G>A	c.(1024-1026)TCG>TCA	p.S342S	ITIH4_uc011bem.1_5'Flank|ITIH4_uc011ben.1_5'Flank|ITIH4_uc003dfz.2_5'Flank|ITIH4_uc010hmp.1_5'Flank|MUSTN1_uc010hmq.1_RNA|MUSTN1_uc003dga.3_Silent_p.S52S|MUSTN1_uc003dgb.3_3'UTR	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	Error:Variant_position_missing_in_Q86TL2_after_alignment						integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		ACGGGGCGGCCGAGCCAGCTT	0.602		NA											22	25					0	0	0	0
DHFRL1	200895	broad.mit.edu	37	3	93780144	93780144	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:93780144C>T	uc003dri.2	-	2	378	c.212G>A	c.(211-213)AGA>AAA	p.R71K	DHFRL1_uc003drj.2_Missense_Mutation_p.R71K|NSUN3_uc003drk.2_5'Flank|NSUN3_uc003drl.1_5'Flank	NM_176815	NP_789785	Q86XF0	DYRL1_HUMAN	dihydrofolate reductase-like 1	71	DHFR.	Substrate (By similarity).			glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process		dihydrofolate reductase activity|NADP binding				0						TAAATTAATTCTATCCTTTAA	0.413		NA											7	613					0	0	0	0
OR5H15	403274	broad.mit.edu	37	3	97887885	97887885	+	Silent	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:97887885C>G	uc011bgu.1	+	1	342	c.342C>G	c.(340-342)CTC>CTG	p.L114L		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AATGTTTTCTCTTGGCAACAA	0.378		NA											4	562					0	0	0	0
TOMM70A	9868	broad.mit.edu	37	3	100084508	100084508	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:100084508T>G	uc003dtw.2	-	12	2159	c.1727A>C	c.(1726-1728)AAA>ACA	p.K576T		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	576	Cytoplasmic (Potential).|TPR 10.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						CATTTCCGATTTGGCCAGGTT	0.398		NA											5	455					0	0	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111769615	111769615	+	Silent	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:111769615T>C	uc010hqb.2	+	7	980	c.810T>C	c.(808-810)TGT>TGC	p.C270C	TMPRSS7_uc011bhr.1_Silent_p.C125C	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	396	Extracellular (Potential).|CUB 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						AATGCAAGTGTACCTGGAAAT	0.353		NA											111	560					0	0	0	0
EPHB1	2047	broad.mit.edu	37	3	134644682	134644682	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:134644682C>A	uc003eqt.2	+	2	303	c.83C>A	c.(82-84)GCT>GAT	p.A28D	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.A28D	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	28	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						ACCAGAACGGCTACTGCAGAG	0.458		NA											3	29					6.4e-05	7.06e-05	1	0
CLSTN2	64084	broad.mit.edu	37	3	140178491	140178491	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:140178491G>T	uc003etn.2	+	7	1292	c.1102G>T	c.(1102-1104)GAT>TAT	p.D368Y	CLSTN2_uc003etm.2_Missense_Mutation_p.D368Y	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	368	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CAAAGTCCCCGATGGGATTGT	0.577		NA								HNSCC(16;0.037)			28	150					4.6e-10	5.31e-10	1	0
RSRC1	51319	broad.mit.edu	37	3	157921018	157921018	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:157921018C>T	uc003fbt.2	+	4	589	c.478C>T	c.(478-480)CAT>TAT	p.H160Y	RSRC1_uc011bou.1_Intron|RSRC1_uc003fbu.1_Missense_Mutation_p.H160Y|RSRC1_uc003fbv.2_Intron	NM_016625	NP_057709	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	160					nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding				0			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			caaggaATTACATAACATCAA	0.333		NA											33	10					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			30	218					0	0	0	0
YEATS2	55689	broad.mit.edu	37	3	183471980	183471980	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:183471980G>C	uc003fly.2	+	11	1412	c.1217G>C	c.(1216-1218)AGA>ACA	p.R406T		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	406					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCATTGGAAAGAACACCCACC	0.443		NA											12	781					0	0	0	0
ECE2	9718	broad.mit.edu	37	3	184008348	184008348	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:184008348G>A	uc003fni.3	+	15	2051	c.2013G>A	c.(2011-2013)TGG>TGA	p.W671*	ECE2_uc011brh.1_Nonsense_Mutation_p.W524*|ECE2_uc003fnl.3_Nonsense_Mutation_p.W599*|ECE2_uc003fnm.3_Nonsense_Mutation_p.W553*|ECE2_uc003fnk.3_Nonsense_Mutation_p.W524*|ECE2_uc011bri.1_Nonsense_Mutation_p.W586*|ECE2_uc010hxv.2_Nonsense_Mutation_p.W315*	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	671	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCGCCAGGTGGAGCATGACCC	0.622		NA											14	522					0	0	0	0
BCL6	604	broad.mit.edu	37	3	187447102	187447102	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:187447102G>A	uc003frp.3	-	5	1548	c.1091C>T	c.(1090-1092)GCC>GTC	p.A364V	BCL6_uc011bsf.1_Missense_Mutation_p.A364V|BCL6_uc010hza.2_Missense_Mutation_p.A262V|BCL6_uc003frq.1_Missense_Mutation_p.A364V	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	364					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GGGGCTCTTGGCTGGAGGGGA	0.577		NA	T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								18	863					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195486032	195486032	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:195486032G>A	uc011bto.1	-	18	15025	c.14565C>T	c.(14563-14565)TTC>TTT	p.F4855F	MUC4_uc003fuz.2_Silent_p.F581F|MUC4_uc003fva.2_Silent_p.F463F|MUC4_uc003fvb.2_Silent_p.F499F|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Silent_p.F499F|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Silent_p.F463F|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Silent_p.F547F|MUC4_uc011bti.1_Silent_p.F547F|MUC4_uc011btj.1_Silent_p.F724F|MUC4_uc011btk.1_Silent_p.F463F|MUC4_uc011btl.1_Silent_p.F492F|MUC4_uc011btm.1_Silent_p.F672F|MUC4_uc011btn.1_Silent_p.F463F|MUC4_uc003fvo.2_Silent_p.F747F|MUC4_uc003fvp.2_Silent_p.F696F	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1740					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTCTGAGCGTGAAGTTGGCAT	0.552		NA											7	898					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195517519	195517519	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:195517519G>C	uc011bto.1	-	2	1392	c.932C>G	c.(931-933)TCA>TGA	p.S311*	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Nonsense_Mutation_p.S193*	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	316					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGAAGTCCTTGAGAAAGTTGC	0.473		NA											6	606					0	0	0	0
LRCH3	84859	broad.mit.edu	37	3	197585712	197585712	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr3:197585712C>T	uc011bul.1	+	15	1657	c.1652C>T	c.(1651-1653)TCA>TTA	p.S551L	LRCH3_uc003fyj.1_Missense_Mutation_p.S551L|LRCH3_uc011bum.1_Intron|LRCH3_uc011bun.1_Missense_Mutation_p.S397L|LRCH3_uc003fyk.2_Missense_Mutation_p.S146L	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	551						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		TAGTCGCTGTCAGGGTTGAAT	0.438		NA											86	415					0	0	0	0
APBB2	323	broad.mit.edu	37	4	40936491	40936491	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:40936491G>A	uc003gvl.2	-	10	1863	c.1233C>T	c.(1231-1233)AAC>AAT	p.N411N	APBB2_uc010ifu.2_5'UTR|APBB2_uc003gvm.2_Silent_p.N390N|APBB2_uc003gvn.2_Silent_p.N412N|APBB2_uc011byt.1_Silent_p.N373N	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	411					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						CTGGGTCACTGTTGATACTAC	0.383		NA											16	88					0	0	0	0
TXK	7294	broad.mit.edu	37	4	48096216	48096216	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:48096216G>A	uc003gxx.3	-	8	673	c.587C>T	c.(586-588)ACG>ATG	p.T196M	TXK_uc003gxy.1_Missense_Mutation_p.T196M	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	196	SH2.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGCAGCCTCCGTACTTCTACA	0.373		NA											8	58					0	0	0	0
PDHA2	5161	broad.mit.edu	37	4	96762282	96762282	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:96762282C>T	uc003htr.3	+	1	1044	c.981C>T	c.(979-981)CTC>CTT	p.L327L		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	327					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ACAGCAAGCTCGCCACTGTGG	0.428		NA											40	53					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126371107	126371107	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:126371107A>T	uc003ifj.3	+	9	8936	c.8936A>T	c.(8935-8937)AAT>ATT	p.N2979I	FAT4_uc011cgp.1_Missense_Mutation_p.N1277I|FAT4_uc003ifi.1_Missense_Mutation_p.N457I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2979	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGTAATGACAATGCACCTCAA	0.343		NA											37	65					0	0	0	0
MAP9	79884	broad.mit.edu	37	4	156274418	156274418	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:156274418C>G	uc003ios.2	-	11	1719	c.1455G>C	c.(1453-1455)AAG>AAC	p.K485N	MAP9_uc011cin.1_Missense_Mutation_p.K460N|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.K484N	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	485	Potential.				cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CAGCTATTTTCTTTGCTTCCT	0.353		NA											8	119					0	0	0	0
MAP9	79884	broad.mit.edu	37	4	156289952	156289952	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:156289952C>A	uc003ios.2	-	5	758	c.494G>T	c.(493-495)AGC>ATC	p.S165I	MAP9_uc011cin.1_Missense_Mutation_p.S164I|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.S164I|MAP9_uc010iqb.1_Missense_Mutation_p.S92I	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	165					cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TGTGTCAAGGCTGTTGTTTTC	0.388		NA											38	69					6.21e-16	7.3e-16	1	0
PDGFC	56034	broad.mit.edu	37	4	157771474	157771474	+	Silent	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr4:157771474C>G	uc003iph.1	-	2	704	c.213G>C	c.(211-213)ACG>ACC	p.T71T	PDGFC_uc003ipi.1_5'UTR|PDGFC_uc011cis.1_Intron|PDGFC_uc011cir.1_5'UTR	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	71	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		ATACCAAGACCGTATTTCTTG	0.388		NA											41	67					0	0	0	0
SDHA	6389	broad.mit.edu	37	5	233625	233625	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:233625G>A	uc003jao.3	+	8	1044	c.929G>A	c.(928-930)GGA>GAA	p.G310E	SDHA_uc003jan.2_Missense_Mutation_p.G310E|SDHA_uc011clv.1_Missense_Mutation_p.G310E|SDHA_uc011clw.1_Missense_Mutation_p.G262E|SDHA_uc003jap.3_Missense_Mutation_p.G310E|SDHA_uc003jaq.3_Missense_Mutation_p.G85E|SDHA_uc003jar.3_5'UTR	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	310					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	ATTACGGAAGGATGTCGTGGA	0.438		NA							Familial_Paragangliomas				93	150					0	0	0	0
CTNND2	1501	broad.mit.edu	37	5	11732259	11732259	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:11732259C>A	uc003jfa.1	-	2	308	c.163G>T	c.(163-165)GTC>TTC	p.V55F	CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	55	Potential.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGTTCTTTGACTGAGGCGAGG	0.423		NA											66	104					2.15e-23	2.57e-23	1	0
CDH10	1008	broad.mit.edu	37	5	24511507	24511507	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:24511507C>A	uc003jgr.1	-	6	1263	c.931G>T	c.(931-933)GGT>TGT	p.G311C	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	311	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GTACCGTCACCATCAATAATT	0.433		NA								HNSCC(23;0.051)			87	161					1.8e-35	2.18e-35	1	0
CDH9	1007	broad.mit.edu	37	5	26881576	26881576	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:26881576G>T	uc003jgs.1	-	12	2208	c.2039C>A	c.(2038-2040)CCA>CAA	p.P680Q	CDH9_uc011cnv.1_Missense_Mutation_p.P273Q	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	680	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TCTTGCCTCTGGATTCCTTAA	0.433		NA											14	267					1.5e-05	1.66e-05	1	0
C6	729	broad.mit.edu	37	5	41199909	41199909	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:41199909C>A	uc003jmk.2	-	4	616	c.406G>T	c.(406-408)GAA>TAA	p.E136*	C6_uc003jml.1_Nonsense_Mutation_p.E136*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	136					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCAGCCTCTTCAATTTTGCAG	0.428		NA											5	154					0.000602214	0.000650585	1	0
HTR1A	3350	broad.mit.edu	37	5	63256897	63256897	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:63256897C>T	uc011cqt.1	-	1	650	c.650G>A	c.(649-651)CGC>CAC	p.R217H		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	217	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TCGGAATATGCGCCCATAGAG	0.587		NA											5	186					0	0	0	0
KCNN2	3781	broad.mit.edu	37	5	113699624	113699624	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:113699624C>T	uc003kqo.2	+	2	965	c.508C>T	c.(508-510)CTG>TTG	p.L170L		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	170	Helical; Name=Segment S2; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TTCCTTAGCTCTGAAATGCCT	0.483		NA											43	84					0	0	0	0
CEP120	153241	broad.mit.edu	37	5	122682331	122682331	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:122682331A>G	uc003ktk.2	-	21	2925	c.2843T>C	c.(2842-2844)CTG>CCG	p.L948P	CEP120_uc011cwq.1_Missense_Mutation_p.L757P	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	948						centrosome				ovary(1)	1						TTCTTCTATCAGGCGAGTCAA	0.418		NA											4	290					0	0	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711638	140711638	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:140711638G>A	uc003lji.1	+	1	1387	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	PCDHGA1_uc011dan.1_Missense_Mutation_p.E463K	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	463	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACATTCCCGAAAACAACCC	0.468		NA											68	123					0	0	0	0
C5orf58	133874	broad.mit.edu	37	5	169673114	169673114	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:169673114C>G	uc010jjn.2	+	4	389	c.306C>G	c.(304-306)ATC>ATG	p.I102M	C5orf58_uc003mal.2_Intron	NM_001102609	NP_001096079	C9J3I9	CE058_HUMAN	hypothetical protein LOC133874	102											0						GTTTTTCTATCTGATTTCTTA	0.289		NA											3	75					0	0	0	0
RUFY1	80230	broad.mit.edu	37	5	178987158	178987158	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:178987158T>C	uc003mka.1	+	2	443	c.443T>C	c.(442-444)TTC>TCC	p.F148S	RUFY1_uc003mkb.1_Missense_Mutation_p.F40S|RUFY1_uc003mkc.1_Missense_Mutation_p.F40S	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	148	RUN.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGCAGCAGTTCTTTGTAGTG	0.572		NA								HNSCC(44;0.11)			14	25					0	0	0	0
MAML1	9794	broad.mit.edu	37	5	179201801	179201801	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr5:179201801C>T	uc003mkm.2	+	5	3237	c.2974C>T	c.(2974-2976)CTG>TTG	p.L992L	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	992					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACACACCGATCTGATCGACTC	0.557		NA											5	107					0	0	0	0
PRPF4B	8899	broad.mit.edu	37	6	4032653	4032653	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:4032653A>G	uc003mvv.2	+	2	993	c.902A>G	c.(901-903)AAA>AGA	p.K301R	PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	301	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TTAAGAGGTAAATCCAAAGAC	0.353		NA											122	30					0	0	0	0
PRPF4B	8899	broad.mit.edu	37	6	4044117	4044117	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:4044117C>T	uc003mvv.2	+	6	1812	c.1721C>T	c.(1720-1722)ACG>ATG	p.T574M	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	574						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CAGAGCAGTACGAGAACACGA	0.418		NA											60	20					0	0	0	0
BAT2	7916	broad.mit.edu	37	6	31605326	31605326	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:31605326G>A	uc003nvb.3	+	31	6686	c.6437G>A	c.(6436-6438)CGA>CAA	p.R2146Q	BAT2_uc003nvc.3_Missense_Mutation_p.R2146Q	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	2146						cytoplasm|nucleus	protein binding				0						CCTGGGTCCCGAGGGGACAAG	0.632		NA											6	84					0	0	0	0
TREML2	79865	broad.mit.edu	37	6	41162432	41162432	+	Silent	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:41162432G>C	uc010jxm.1	-	3	695	c.516C>G	c.(514-516)CTC>CTG	p.L172L		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	172	Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCAAGGTGATGAGTCCTGGGG	0.577		NA											7	40					0	0	0	0
DEFB114	245928	broad.mit.edu	37	6	49928019	49928019	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:49928019C>G	uc011dwp.1	-	2	196	c.196G>C	c.(196-198)GAT>CAT	p.D66H		NM_001037499	NP_001032588	Q30KQ6	DB114_HUMAN	beta-defensin 114 precursor	66					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					AACATATCATCTTCTTCATAC	0.358		NA											17	39					0	0	0	0
SENP6	26054	broad.mit.edu	37	6	76376512	76376512	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:76376512G>C	uc003pid.3	+	10	1698	c.1079G>C	c.(1078-1080)TGT>TCT	p.C360S	SENP6_uc003pie.3_Missense_Mutation_p.C353S|SENP6_uc010kbf.2_RNA|SENP6_uc003pic.2_Missense_Mutation_p.C353S|SENP6_uc003pif.1_Missense_Mutation_p.C251S	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	360					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GATTCAGCATGTTCTTCCCCT	0.423		NA											20	87					0	0	0	0
IBTK	25998	broad.mit.edu	37	6	82923970	82923970	+	Silent	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:82923970T>C	uc003pjl.1	-	12	2705	c.2178A>G	c.(2176-2178)AAA>AAG	p.K726K	IBTK_uc011dyv.1_Silent_p.K726K|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Silent_p.K420K|IBTK_uc003pjm.2_Silent_p.K726K	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	726					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TGAAGTCGAATTTCTTTGCAA	0.338		NA											42	69					0	0	0	0
CDC40	51362	broad.mit.edu	37	6	110530349	110530349	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:110530349G>T	uc003pua.2	+	5	577	c.553G>T	c.(553-555)GAT>TAT	p.D185Y		NM_015891	NP_056975	O60508	PRP17_HUMAN	cell division cycle 40 homolog	185					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		TAAAGAAAATGATGCATCCAA	0.299		NA											6	70					5.94e-07	6.71e-07	1	0
C6orf97	80129	broad.mit.edu	37	6	151894461	151894461	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr6:151894461G>C	uc003qol.2	+	6	1016	c.927G>C	c.(925-927)TTG>TTC	p.L309F		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	309											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AGAAGAGTTTGAAGGCCAGTC	0.512		NA											3	72					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11468681	11468681	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:11468681G>A	uc003ssf.3	-	14	3388	c.3136C>T	c.(3136-3138)CGC>TGC	p.R1046C		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1046	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTGCTGCAGCGCGACCAGTTG	0.517		NA								HNSCC(18;0.044)			110	166					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11676072	11676072	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:11676072G>A	uc003ssf.3	-	2	959	c.707C>T	c.(706-708)ACG>ATG	p.T236M		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	236	Extracellular (Potential).|TSP type-1 2.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTGGAACTCCGTCAGGTTTGG	0.657		NA								HNSCC(18;0.044)			4	38					0	0	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764127	92764127	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:92764127C>A	uc003umh.1	-	5	2374	c.1158G>T	c.(1156-1158)ATG>ATT	p.M386I	SAMD9L_uc003umj.1_Missense_Mutation_p.M386I|SAMD9L_uc003umi.1_Missense_Mutation_p.M386I|SAMD9L_uc010lfb.1_Missense_Mutation_p.M386I|SAMD9L_uc003umk.1_Missense_Mutation_p.M386I|SAMD9L_uc010lfc.1_Missense_Mutation_p.M386I|SAMD9L_uc010lfd.1_Missense_Mutation_p.M386I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	386										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCATTGCCTTCATTCCATACT	0.393		NA											34	349					2.85e-18	3.37e-18	1	0
SAMD9L	219285	broad.mit.edu	37	7	92764780	92764780	+	Missense_Mutation	SNP	C	C	G	rs144605831	byFrequency	TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:92764780C>G	uc003umh.1	-	5	1721	c.505G>C	c.(505-507)GAT>CAT	p.D169H	SAMD9L_uc003umj.1_Missense_Mutation_p.D169H|SAMD9L_uc003umi.1_Missense_Mutation_p.D169H|SAMD9L_uc010lfb.1_Missense_Mutation_p.D169H|SAMD9L_uc003umk.1_Missense_Mutation_p.D169H|SAMD9L_uc010lfc.1_Missense_Mutation_p.D169H|SAMD9L_uc010lfd.1_Missense_Mutation_p.D169H|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	169										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGGAACTGATCAAAAGGATAT	0.363		NA											18	231					0	0	0	0
PLOD3	8985	broad.mit.edu	37	7	100859263	100859263	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:100859263G>A	uc003uyd.2	-	5	997	c.541C>T	c.(541-543)CGC>TGC	p.R181C	ZNHIT1_uc003uye.2_5'Flank|ZNHIT1_uc003uyf.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	181					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	TTCCACTGGCGCACGATTTGG	0.617		NA											34	61					0	0	0	0
FOXP2	93986	broad.mit.edu	37	7	114299704	114299704	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:114299704C>G	uc003vhb.2	+	13	1997	c.1623C>G	c.(1621-1623)TTC>TTG	p.F541L	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.F566L|FOXP2_uc003vha.2_Missense_Mutation_p.F449L|FOXP2_uc011kmu.1_Missense_Mutation_p.F558L|FOXP2_uc011kmv.1_Missense_Mutation_p.F540L|FOXP2_uc010ljz.1_Missense_Mutation_p.F356L|FOXP2_uc003vhe.1_Missense_Mutation_p.F111L	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	541	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TTGCTTACTTCAGGCGTAATG	0.323		NA											4	127					0	0	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121653325	121653325	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:121653325G>T	uc003vjy.2	+	12	4620	c.4225G>T	c.(4225-4227)GAT>TAT	p.D1409Y	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1409	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TGCCAAATCTGATGCCGGTTT	0.338		NA											68	89					1.84e-34	2.22e-34	1	0
CPA2	1358	broad.mit.edu	37	7	129929571	129929571	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:129929571G>C	uc003vpq.2	+	11	1263	c.1244G>C	c.(1243-1245)CGA>CCA	p.R415P		NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	415					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GAGCATGTGCGAGACCACCCC	0.517		NA											33	85					0	0	0	0
TRIM24	8805	broad.mit.edu	37	7	138210029	138210029	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:138210029A>G	uc003vuc.2	+	5	1023	c.808A>G	c.(808-810)ATA>GTA	p.I270V	TRIM24_uc003vub.2_Missense_Mutation_p.I270V	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	270					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						GAAAGTGATCATAGATACACT	0.269		NA											11	33					0	0	0	0
KIAA1549	57670	broad.mit.edu	37	7	138545904	138545904	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr7:138545904G>A	uc011kql.1	-	16	5277	c.5228C>T	c.(5227-5229)ACG>ATG	p.T1743M	KIAA1549_uc011kqi.1_Missense_Mutation_p.T527M|KIAA1549_uc003vuk.3_Missense_Mutation_p.T1693M|KIAA1549_uc011kqj.1_Missense_Mutation_p.T1743M|KIAA1549_uc011kqk.1_Missense_Mutation_p.T527M	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1743						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						ATTGTTGGCCGTCTGGGCTGG	0.602		NA	O	BRAF	pilocytic astrocytoma								44	54					0	0	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729045	37729045	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:37729045T>A	uc003xkm.1	-	4	3319	c.3275A>T	c.(3274-3276)GAC>GTC	p.D1092V	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.D421V|RAB11FIP1_uc003xko.1_Missense_Mutation_p.D421V|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	1092					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TACAGGATTGTCCAGGGATGT	0.557		NA									OREG0018713	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	167	259					0	0	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730417	37730417	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:37730417C>T	uc003xkm.1	-	4	1947	c.1903G>A	c.(1903-1905)GAG>AAG	p.E635K	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_5'UTR|RAB11FIP1_uc003xko.1_5'UTR|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	635					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GTTTGCAACTCTGCCTTAGGG	0.502		NA											24	219					0	0	0	0
CHRNB3	1142	broad.mit.edu	37	8	42587115	42587115	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:42587115T>C	uc003xpi.1	+	5	793	c.665T>C	c.(664-666)TTT>TCT	p.F222S		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	222	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TCCTATCCCTTTATCACGTAT	0.478		NA											61	61					0	0	0	0
CA2	760	broad.mit.edu	37	8	86389459	86389459	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:86389459G>A	uc003ydk.2	+	6	798	c.618G>A	c.(616-618)GTG>GTA	p.V206V		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	206					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TGGAATGTGTGACCTGGATTG	0.512		NA											9	430					0	0	0	0
RGS22	26166	broad.mit.edu	37	8	101065137	101065137	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:101065137G>A	uc003yjb.1	-	10	1777	c.1582C>T	c.(1582-1584)CAC>TAC	p.H528Y	RGS22_uc003yja.1_Missense_Mutation_p.H347Y|RGS22_uc003yjc.1_Missense_Mutation_p.H516Y|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	528					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGACGGAGGTGCCAGAATTTC	0.408		NA											119	188					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104898340	104898340	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:104898340G>A	uc003yls.2	+	2	1088	c.847G>A	c.(847-849)GGT>AGT	p.G283S	RIMS2_uc003ylp.2_Missense_Mutation_p.G505S|RIMS2_uc003ylw.2_Missense_Mutation_p.G313S|RIMS2_uc003ylq.2_Missense_Mutation_p.G313S|RIMS2_uc003ylr.2_Missense_Mutation_p.G313S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	536					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAAGAAAGGCGGTAAAATGCG	0.428		NA								HNSCC(12;0.0054)			34	49					0	0	0	0
LRP12	29967	broad.mit.edu	37	8	105510194	105510194	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:105510194C>T	uc003yma.2	-	5	681	c.586G>A	c.(586-588)GAT>AAT	p.D196N	LRP12_uc003ymb.2_Missense_Mutation_p.D177N|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	196	Extracellular (Potential).|LDL-receptor class A 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATCTCTTCATCGGAACTATCT	0.423		NA											4	210					0	0	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428272	128428272	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:128428272G>A	uc003ysf.2	+	1	416	c.161G>A	c.(160-162)GGC>GAC	p.G54D	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_RNA	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	54						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTTGGGCCAGGCTCTGAGGTG	0.677		NA											9	8					0	0	0	0
ZNF16	7564	broad.mit.edu	37	8	146157609	146157609	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr8:146157609C>G	uc003zet.2	-	4	751	c.564G>C	c.(562-564)CAG>CAC	p.Q188H	ZNF16_uc003zeu.2_Missense_Mutation_p.Q188H	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		GCTGGAAACTCTGGCCACCCA	0.493		NA											28	260					0	0	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88162058	88162058	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:88162058G>A	uc011ltd.1	-	25	3680	c.3647C>T	c.(3646-3648)TCT>TTT	p.S1216F	AGTPBP1_uc004aod.3_Missense_Mutation_p.S842F|AGTPBP1_uc011ltc.1_3'UTR|AGTPBP1_uc010mqc.2_Missense_Mutation_p.S1176F|AGTPBP1_uc011lte.1_Missense_Mutation_p.S1228F	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1216					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						TTCAGAGTCAGAAAGTACTTC	0.363		NA											8	152					0	0	0	0
ZNF883	169834	broad.mit.edu	37	9	115760138	115760138	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:115760138G>A	uc011lwy.1	-	5	1641	c.402C>T	c.(400-402)TTC>TTT	p.F134F		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	134	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGATATGGCTGAAAGCTTTCC	0.393		NA											6	115					0	0	0	0
PAPPA	5069	broad.mit.edu	37	9	118949729	118949729	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:118949729C>G	uc004bjn.2	+	2	1093	c.712C>G	c.(712-714)CTC>GTC	p.L238V	PAPPA_uc011lxp.1_Missense_Mutation_p.L31V|PAPPA_uc011lxq.1_Missense_Mutation_p.L31V	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	238					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GTGCAAAGTGCTCATGTTAGG	0.557		NA											19	155					0	0	0	0
CEP110	11064	broad.mit.edu	37	9	123880662	123880662	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:123880662G>C	uc004bkx.1	+	10	1525	c.1494G>C	c.(1492-1494)TTG>TTC	p.L498F	CEP110_uc004bky.1_Missense_Mutation_p.L102F	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	498	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ACAAGCAGTTGAGTGGTAGAC	0.393		NA											5	342					0	0	0	0
SPTAN1	6709	broad.mit.edu	37	9	131370227	131370227	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:131370227G>A	uc004bvl.3	+	33	4356	c.4243G>A	c.(4243-4245)GAG>AAG	p.E1415K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1415K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1395K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1415	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGCCAGCCCTGAGATCAAGCA	0.547		NA											7	158					0	0	0	0
ZER1	10444	broad.mit.edu	37	9	131503106	131503106	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chr9:131503106C>T	uc004bwa.1	-	12	2231	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	600	ARM 3.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TCCTTCACTTCTGCCACATTC	0.403		NA											12	192					0	0	0	0
CSF2RA	1438	broad.mit.edu	37	X	1409269	1409269	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:1409269C>T	uc010nct.2	+	8	835	c.513C>T	c.(511-513)GAC>GAT	p.D171D	CSF2RA_uc011mhb.1_Silent_p.D171D|CSF2RA_uc004cpq.2_Silent_p.D171D|CSF2RA_uc004cpn.2_Silent_p.D171D|CSF2RA_uc004cpo.2_Silent_p.D171D|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Silent_p.D38D|CSF2RA_uc004cpp.2_Silent_p.D171D|CSF2RA_uc010ncv.2_Silent_p.D171D|CSF2RA_uc004cpr.2_Silent_p.D171D	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	171	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ACATACAAGACTCAGGAACCC	0.333		NA											96	61					0	0	0	0
YY2	404281	broad.mit.edu	37	X	21875244	21875244	+	Silent	SNP	G	G	A			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:21875244G>A	uc011mjp.1	+	1	642	c.642G>A	c.(640-642)TTG>TTA	p.L214L	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Silent_p.L432L|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CCGAGTACTTGAAAGGGAAGA	0.483		NA											9	192					0	0	0	0
ACRC	93953	broad.mit.edu	37	X	70823703	70823703	+	Silent	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:70823703C>T	uc004eae.2	+	8	1077	c.576C>T	c.(574-576)AAC>AAT	p.N192N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	192	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					CCGACGACAACAGTGATGATT	0.498		NA											6	245					0	0	0	0
ZNF711	7552	broad.mit.edu	37	X	84502625	84502625	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:84502625G>T	uc004eeo.2	+	3	394	c.47G>T	c.(46-48)AGA>ATA	p.R16I	ZNF711_uc004eep.2_Missense_Mutation_p.R16I|ZNF711_uc004eeq.2_Missense_Mutation_p.R16I	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	16					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						CCAGACTCTAGAATGGCCCAT	0.333		NA											20	101					4.35e-09	5e-09	1	0
IRS4	8471	broad.mit.edu	37	X	107978638	107978638	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:107978638C>T	uc004eoc.2	-	1	970	c.937G>A	c.(937-939)GAC>AAC	p.D313N		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	313	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						ACCACACAGTCATCGACCTGC	0.547		NA											6	169					0	0	0	0
HTATSF1	27336	broad.mit.edu	37	X	135581841	135581841	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-4741-01A-01D-1434-08	TCGA-CN-4741-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3486c689-d7ae-4ce8-8df5-ac8271b4661d	5c237a40-3697-4c30-99ae-9288b4f7a239	g.chrX:135581841G>C	uc004ezw.2	+	3	693	c.271G>C	c.(271-273)GAT>CAT	p.D91H	HTATSF1_uc004ezx.2_Missense_Mutation_p.D91H	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	91					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAATGTTGAAGATGTCCATGC	0.443		NA											9	117					0	0	0	0