Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
GLTPD1	80772	broad.mit.edu	37	1	1263084	1263084	+	Missense_Mutation	SNP	C	C	A	rs145750452		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:1263084C>A	uc001aeo.2	+	3	1001	c.586C>A	c.(586-588)CGT>AGT	p.R196S		NM_001029885	NP_001025056	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	196						cytoplasm	glycolipid binding|glycolipid transporter activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTTCATCCAGCGTGTCTACAA	0.672		NA											21	64					1.64e-05	1.95e-05	1	0
SPSB1	80176	broad.mit.edu	37	1	9416393	9416393	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:9416393G>T	uc010oae.1	+	2	782	c.443G>T	c.(442-444)CGG>CTG	p.R148L	SPSB1_uc001apv.2_Missense_Mutation_p.R148L	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	148	B30.2/SPRY.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		GGGCGCAACCGGCTCTACCAC	0.602		NA											25	47					1.85e-09	2.46e-09	1	0
NPPB	4879	broad.mit.edu	37	1	11918861	11918861	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:11918861C>A	uc001atj.2	-	1	132	c.30G>T	c.(28-30)GCG>GCT	p.A10A		NM_002521	NP_002512	P16860	ANFB_HUMAN	natriuretic peptide precursor B preproprotein	10					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	GGAGCAGGAGCGCCCGGGAAG	0.527		NA											37	60					2.41e-17	3.52e-17	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12884844	12884844	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:12884844C>T	uc001auk.2	-	4	1463	c.1267G>A	c.(1267-1269)GAC>AAC	p.D423N		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	423											0						AATGACCTGTCGCCATGGTCA	0.468		NA											6	211					0	0	0	0
IGSF21	84966	broad.mit.edu	37	1	18692115	18692115	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:18692115C>G	uc001bau.1	+	6	1322	c.939C>G	c.(937-939)ATC>ATG	p.I313M	IGSF21_uc001bav.1_Missense_Mutation_p.I134M	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	313						extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		ACCCACAGATCGACAACGAGG	0.642		NA											23	57					0	0	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28285042	28285042	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:28285042G>T	uc001bpg.2	+	8	1252	c.1061G>T	c.(1060-1062)CGC>CTC	p.R354L	SMPDL3B_uc010ofq.1_Missense_Mutation_p.R148L|SMPDL3B_uc010ofr.1_Missense_Mutation_p.R306L|XKR8_uc001bph.1_5'Flank	NM_014474	NP_055289	Q92485	ASM3B_HUMAN	acid sphingomyelinase-like phosphodiesterase 3B	354					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			ovary(3)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GGGACGCCGCGCTGGGAGCTC	0.632		NA											27	43					2.09e-25	3.21e-25	1	0
CD53	963	broad.mit.edu	37	1	111435056	111435056	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:111435056G>T	uc001dzw.2	+	4	324	c.153G>T	c.(151-153)ACG>ACT	p.T51T	CD53_uc001dzx.2_Silent_p.T51T|CD53_uc010owa.1_Silent_p.T51T|CD53_uc001dzy.2_Silent_p.T51T	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	51	Extracellular (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		CCTCCCTCACGCTGGGCAATG	0.507		NA											39	105					2.76e-19	4.09e-19	1	0
NBPF10	100132406	broad.mit.edu	37	1	145296541	145296541	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:145296541G>C	uc001end.3	+	3	498	c.463G>C	c.(463-465)GCA>CCA	p.A155P	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.A155P|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	155											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GTGTAGACTGGCACAGCACCT	0.577		NA											44	331					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145368536	145368536	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:145368536C>G	uc001end.3	+	86	10774	c.10739C>G	c.(10738-10740)CCT>CGT	p.P3580R	NBPF9_uc010oye.1_Missense_Mutation_p.P864R|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Missense_Mutation_p.P433R|NBPF10_uc010oyk.1_Missense_Mutation_p.P221R|NBPF10_uc010oyl.1_Missense_Mutation_p.P221R	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3505											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTGAACTACCTGACTCATTC	0.458		NA											9	486					0	0	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783631	149783631	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:149783631T>A	uc001esr.2	-	1	298	c.248A>T	c.(247-249)CAC>CTC	p.H83L	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.H83L|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.H83L	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	83					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					CTTGTTGTAGTGCGCCAGGCG	0.667		NA											37	89					0	0	0	0
PLEKHO1	51177	broad.mit.edu	37	1	150131289	150131289	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:150131289C>A	uc001ett.2	+	6	1079	c.801C>A	c.(799-801)GGC>GGA	p.G267G	PLEKHO1_uc001etr.2_Silent_p.G95G|PLEKHO1_uc001ets.2_Silent_p.G84G|PLEKHO1_uc001etu.2_Silent_p.G95G	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	267	Interaction with ATM, CKIP, IFP35 and NMI.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGAGAAAGGCCGCTGCGCCT	0.647		NA											20	46					1.64e-05	1.95e-05	1	0
HORMAD1	84072	broad.mit.edu	37	1	150689696	150689696	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:150689696C>A	uc001evk.1	-	3	202	c.96G>T	c.(94-96)AGG>AGT	p.R32S	HORMAD1_uc001evl.1_Missense_Mutation_p.R32S|HORMAD1_uc001evm.1_5'UTR	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	32	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			CTGCTAGAAGCCTCTTCACTA	0.348		NA											43	146					7.71e-36	1.21e-35	1	0
CTSS	1520	broad.mit.edu	37	1	150724474	150724474	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:150724474C>A	uc001evn.2	-	5	543	c.410G>T	c.(409-411)GGT>GTT	p.G137V	CTSS_uc010pcj.1_Missense_Mutation_p.G87V|CTSS_uc001evo.1_Missense_Mutation_p.G137V	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	137					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			CCAGCAAGCACCACAAGAACC	0.498		NA											21	66					3.62e-10	4.88e-10	1	0
FCRL4	83417	broad.mit.edu	37	1	157557067	157557067	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:157557067C>A	uc001fqw.2	-	5	982	c.846G>T	c.(844-846)CAG>CAT	p.Q282H	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	282	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AACACTCACGCTGCACATGGA	0.532		NA											67	227					1.32e-23	2e-23	1	0
FCRL2	79368	broad.mit.edu	37	1	157739772	157739772	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:157739772G>A	uc001fre.2	-	4	538	c.479C>T	c.(478-480)CCG>CTG	p.P160L	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.P160L|FCRL2_uc009wsp.2_Intron|FCRL2_uc010pia.1_Missense_Mutation_p.P160L	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	160	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTGGAGCTCCGGAGAGCTGCT	0.537		NA											25	86					0	0	0	0
FCRL1	115350	broad.mit.edu	37	1	157773822	157773822	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:157773822C>A	uc001frg.2	-	3	245	c.132G>T	c.(130-132)CAG>CAT	p.Q44H	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.Q44H|FCRL1_uc001fri.2_Missense_Mutation_p.Q44H|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	44	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CATCTGAACTCTGTAGAAAGG	0.562		NA											38	149					2.32e-10	3.14e-10	1	0
SPTA1	6708	broad.mit.edu	37	1	158636152	158636152	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:158636152C>A	uc001fst.1	-	16	2373	c.2174G>T	c.(2173-2175)CGA>CTA	p.R725L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	725	Spectrin 8.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTTCCTGAGTCGATTCTGTAC	0.517		NA											10	41					2.27e-07	2.87e-07	1	0
MNDA	4332	broad.mit.edu	37	1	158815619	158815619	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:158815619C>A	uc001fsz.1	+	5	1013	c.813C>A	c.(811-813)TAC>TAA	p.Y271*		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	271	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TATCTGATTACTCTGAATGTA	0.343		NA											13	67					1.5e-05	1.78e-05	1	0
DUSP27	92235	broad.mit.edu	37	1	167096649	167096649	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:167096649A>G	uc001geb.1	+	5	2281	c.2281A>G	c.(2281-2283)AGC>GGC	p.S761G		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	761					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						ACCAGCGGCTAGCTGCCTGGG	0.562		NA											16	73					0	0	0	0
F5	2153	broad.mit.edu	37	1	169526028	169526028	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:169526028G>A	uc001ggg.1	-	6	953	c.808C>T	c.(808-810)CAT>TAT	p.H270Y	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	270	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCGTTGAAATGAATGGAGAAT	0.507		NA											16	64					0	0	0	0
C1orf129	80133	broad.mit.edu	37	1	170927641	170927641	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:170927641C>A	uc001ghg.2	+	4	242	c.112C>A	c.(112-114)CTG>ATG	p.L38M	C1orf129_uc009wvy.2_Translation_Start_Site|C1orf129_uc010plz.1_Missense_Mutation_p.L38M	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	38							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATACTCAGGCCTGTTAAGTAA	0.333		NA											30	142					7.65e-34	1.2e-33	1	0
TNR	7143	broad.mit.edu	37	1	175348704	175348704	+	Silent	SNP	G	G	A	rs140708810		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:175348704G>A	uc001gkp.1	-	7	2028	c.1947C>T	c.(1945-1947)ACC>ACT	p.T649T	TNR_uc009wwu.1_Silent_p.T649T	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	649	Fibronectin type-III 4.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGGTGGCCCTGGTGGTTGGAC	0.532		NA											19	68					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526124	176526124	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:176526124G>T	uc001gkz.2	+	2	1830	c.666G>T	c.(664-666)TGG>TGT	p.W222C	PAPPA2_uc001gky.1_Missense_Mutation_p.W222C|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	222					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCCAACCTTGGCCCAAGCATT	0.562		NA											35	110					2e-19	2.97e-19	1	0
ASTN1	460	broad.mit.edu	37	1	176927497	176927497	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:176927497C>T	uc001glc.2	-	10	1932	c.1720G>A	c.(1720-1722)GAT>AAT	p.D574N	ASTN1_uc001glb.1_Missense_Mutation_p.D574N|ASTN1_uc001gld.1_Missense_Mutation_p.D574N|ASTN1_uc009wwx.1_Missense_Mutation_p.D574N	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	582					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCACAGCATCCTCCATCACA	0.532		NA											13	49					0	0	0	0
TDRD5	163589	broad.mit.edu	37	1	179587802	179587802	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:179587802A>G	uc001gnf.1	+	5	1150	c.900A>G	c.(898-900)AAA>AAG	p.K300K	TDRD5_uc010pnp.1_Silent_p.K300K|TDRD5_uc001gnh.1_5'UTR	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	300	Lotus/OST-HTH 3.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CAGAACTAAAACATAAGATAA	0.289		NA											31	89					0	0	0	0
CACNA1E	777	broad.mit.edu	37	1	181690998	181690998	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:181690998C>A	uc001gow.2	+	16	2226	c.2061C>A	c.(2059-2061)ACC>ACA	p.T687T	CACNA1E_uc009wxs.2_Silent_p.T594T	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	687	Helical; Name=S6 of repeat II.|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TTGTGCTCACCTTGTTTGGCA	0.537		NA											41	139					2.27e-22	3.42e-22	1	0
CACNA1E	777	broad.mit.edu	37	1	181731752	181731752	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:181731752G>A	uc001gow.2	+	33	4813	c.4648G>A	c.(4648-4650)GTG>ATG	p.V1550M	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1438M|CACNA1E_uc001gox.1_Missense_Mutation_p.V776M|CACNA1E_uc009wxt.2_Missense_Mutation_p.V776M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1550	Helical; Name=S3 of repeat IV.|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CTTCATCACCGTGATTGGCAG	0.388		NA											10	26					0	0	0	0
CFHR4	10877	broad.mit.edu	37	1	196871597	196871597	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:196871597T>C	uc001gto.2	+	2	177	c.108T>C	c.(106-108)TAT>TAC	p.Y36Y	CFHR4_uc009wyy.2_Silent_p.Y35Y|CFHR4_uc001gtp.2_Silent_p.Y36Y	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	36	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GTCTATATTATAAGAGTTTGC	0.318		NA											71	176					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198701448	198701448	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:198701448G>T	uc001gur.1	+	19	2168	c.1988G>T	c.(1987-1989)AGC>ATC	p.S663I	PTPRC_uc001gus.1_Missense_Mutation_p.S615I|PTPRC_uc001gut.1_Missense_Mutation_p.S502I|PTPRC_uc009wzf.1_Missense_Mutation_p.S551I|PTPRC_uc010ppg.1_Missense_Mutation_p.S599I	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	663	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CGGGTGTTCAGCAAGTTTCCT	0.398		NA											19	83					3.6e-14	5.11e-14	1	0
NR5A2	2494	broad.mit.edu	37	1	200017865	200017865	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:200017865G>T	uc001gvb.2	+	5	1235	c.1029G>T	c.(1027-1029)GGG>GGT	p.G343G	NR5A2_uc001gvc.2_Silent_p.G297G|NR5A2_uc009wzh.2_Silent_p.G303G|NR5A2_uc010pph.1_Silent_p.G271G	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	343	Ligand-binding.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					GCACCTTTGGGCTTATGTGCA	0.478		NA											42	137					4.14e-30	6.43e-30	1	0
MYOG	4656	broad.mit.edu	37	1	203054660	203054660	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:203054660G>C	uc001gzd.2	-	1	718	c.430C>G	c.(430-432)CGT>GGT	p.R144G		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	144					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						CGGAGGTCACGCTCCTCCTGG	0.701		NA											15	41					0	0	0	0
PLXNA2	5362	broad.mit.edu	37	1	208390886	208390886	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:208390886C>T	uc001hgz.2	-	2	1140	c.382G>A	c.(382-384)GCC>ACC	p.A128T	PLXNA2_uc001hha.3_Missense_Mutation_p.A182T	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	128	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CTCCCACAGGCCAGCAGGCGG	0.587		NA											34	133					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216373030	216373030	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:216373030C>T	uc001hku.1	-	17	4137	c.3750G>A	c.(3748-3750)AAG>AAA	p.K1250K	USH2A_uc001hkv.2_Silent_p.K1250K	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1250	Fibronectin type-III 3.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTTTCTGCATCTTAGGTGGAC	0.478		NA								HNSCC(13;0.011)			21	80					0	0	0	0
KCNK1	3775	broad.mit.edu	37	1	233802661	233802661	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:233802661A>G	uc010pxo.1	+	2	844	c.676A>G	c.(676-678)ATT>GTT	p.I226V	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	226						voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	CCTGAGCACCATTGGCCTGGG	0.483		NA											35	115					0	0	0	0
RGS7	6000	broad.mit.edu	37	1	241094032	241094032	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:241094032C>A	uc001hyv.2	-	6	700	c.370G>T	c.(370-372)GAA>TAA	p.E124*	RGS7_uc010pyh.1_Nonsense_Mutation_p.E98*|RGS7_uc010pyj.1_Nonsense_Mutation_p.E40*|RGS7_uc001hyu.2_Nonsense_Mutation_p.E124*|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Nonsense_Mutation_p.E124*	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	124					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCTGTGTTTTCCGGCTCCCAA	0.383		NA											72	222					4.5e-31	7.02e-31	1	0
MAP1LC3C	440738	broad.mit.edu	37	1	242159636	242159636	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:242159636G>A	uc001hzk.2	-	4	348	c.273C>T	c.(271-273)AAC>AAT	p.N91N		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	91					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCAGGCTCTTGTTGTTCACCA	0.572		NA											41	127					0	0	0	0
PLD5	200150	broad.mit.edu	37	1	242511469	242511469	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:242511469C>A	uc001hzn.1	-	2	392	c.265G>T	c.(265-267)GTG>TTG	p.V89L	PLD5_uc001hzl.3_Missense_Mutation_p.V27L|PLD5_uc001hzm.3_5'UTR|PLD5_uc001hzo.1_5'UTR			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	89	Helical; (Potential).					integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			ATGATGTCCACGGCTGAAAAG	0.448		NA											35	128					6.97e-18	1.02e-17	1	0
CEP170	9859	broad.mit.edu	37	1	243349671	243349671	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:243349671T>A	uc001hzs.2	-	9	1570	c.1162A>T	c.(1162-1164)AGG>TGG	p.R388W	CEP170_uc001hzt.2_Missense_Mutation_p.R388W|CEP170_uc001hzu.2_Missense_Mutation_p.R388W	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	388						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CTACAGCGCCTGTGAGCCCCA	0.438		NA											59	177					0	0	0	0
KIF26B	55083	broad.mit.edu	37	1	245850938	245850938	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:245850938C>G	uc001ibf.1	+	12	5093	c.4653C>G	c.(4651-4653)GAC>GAG	p.D1551E	KIF26B_uc001ibg.1_Missense_Mutation_p.D1169E|KIF26B_uc001ibh.1_Missense_Mutation_p.D793E	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1551					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGGAGCCGGACAGCCTCTCCT	0.662		NA											3	7					0	0	0	0
OR2C3	81472	broad.mit.edu	37	1	247695329	247695329	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:247695329G>T	uc009xgy.2	-	2	847	c.485C>A	c.(484-486)ACG>AAG	p.T162K	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CATGGTGAGCGTGGAGCCCAC	0.557		NA											4	24					1.02e-07	1.31e-07	1	0
OR2M5	127059	broad.mit.edu	37	1	248308673	248308673	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr1:248308673G>T	uc010pze.1	+	1	224	c.224G>T	c.(223-225)TGC>TTC	p.C75F		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ATGCTCATCTGCTCTACCGTA	0.488		NA											289	472					4.04e-157	6.46e-157	1	0
ITGA8	8516	broad.mit.edu	37	10	15649735	15649735	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:15649735G>T	uc001ioc.1	-	17	1705	c.1705C>A	c.(1705-1707)CCT>ACT	p.P569T	ITGA8_uc010qcb.1_Missense_Mutation_p.P554T	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	569	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ATCACAAGAGGGAAGACGCGA	0.448		NA											64	135					2.68e-24	4.09e-24	1	0
SLC39A12	221074	broad.mit.edu	37	10	18242223	18242223	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:18242223G>T	uc001ipo.2	+	2	291	c.18G>T	c.(16-18)AAG>AAT	p.K6N	SLC39A12_uc001ipn.2_Missense_Mutation_p.K6N|SLC39A12_uc001ipp.2_Missense_Mutation_p.K6N|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	6	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TCCGGACAAAGCTCTCAGTAT	0.493		NA											22	67					2.89e-11	3.97e-11	1	0
ARHGAP12	94134	broad.mit.edu	37	10	32141445	32141445	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:32141445C>A	uc001ivz.1	-	6	1440	c.1170G>T	c.(1168-1170)AAG>AAT	p.K390N	ARHGAP12_uc001ivy.1_Missense_Mutation_p.K341N|ARHGAP12_uc009xls.2_Missense_Mutation_p.K341N|ARHGAP12_uc001iwb.1_Missense_Mutation_p.K388N|ARHGAP12_uc001iwc.1_Missense_Mutation_p.K388N|ARHGAP12_uc009xlq.1_Missense_Mutation_p.K341N|ARHGAP12_uc001iwd.1_Missense_Mutation_p.K388N|ARHGAP12_uc009xlr.1_Missense_Mutation_p.K388N	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	390	WW 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				GGTTTATTACCTTTGGCAATT	0.348		NA											44	80					5.24e-18	7.7e-18	1	0
ZNF37A	7587	broad.mit.edu	37	10	38406775	38406775	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:38406775A>G	uc001izk.2	+	8	1515	c.696A>G	c.(694-696)CCA>CCG	p.P232P	ZNF37A_uc001izl.2_Silent_p.P232P|ZNF37A_uc001izm.2_Silent_p.P232P	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	232						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						ATCTCACTCCAATTCAGAGAA	0.338		NA											10	45					0	0	0	0
OGDHL	55753	broad.mit.edu	37	10	50954889	50954889	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:50954889A>C	uc001jie.2	-	10	1345	c.1203T>G	c.(1201-1203)TTT>TTG	p.F401L	OGDHL_uc009xog.2_Missense_Mutation_p.F428L|OGDHL_uc010qgt.1_Missense_Mutation_p.F344L|OGDHL_uc010qgu.1_Missense_Mutation_p.F192L|OGDHL_uc009xoh.2_Missense_Mutation_p.F192L	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	401					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CCTGGCCAGCAAAGGCGGCGT	0.637		NA											10	34					0	0	0	0
RBP4	5950	broad.mit.edu	37	10	95360467	95360467	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:95360467C>A	uc001kit.2	-	3	289	c.205G>T	c.(205-207)GGC>TGC	p.G69C		NM_006744	NP_006735	P02753	RET4_HUMAN	retinol-binding protein 4, plasma precursor	69					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding				0		Colorectal(252;0.122)			Vitamin A(DB00162)	CTCATCTGGCCGGTCTCGTCC	0.647		NA											9	10					5.49e-09	7.2e-09	1	0
PNLIPRP2	5408	broad.mit.edu	37	10	118383495	118383495	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:118383495A>T	uc001lcq.2	+	5	115	c.92A>T	c.(91-93)GAT>GTT	p.D31V	PNLIPRP2_uc009xyu.1_RNA|PNLIPRP2_uc009xyv.1_RNA	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2	30					galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TGCTTTTCTGATGAAAAACCA	0.463		NA											23	39					0	0	0	0
FAM196A	642938	broad.mit.edu	37	10	128974171	128974171	+	Silent	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:128974171G>C	uc001lju.1	-	1	530	c.489C>G	c.(487-489)GGC>GGG	p.G163G	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Silent_p.G163G|FAM196A_uc001ljv.1_Silent_p.G163G|FAM196A_uc009yap.1_Silent_p.G163G	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	163										ovary(2)	2						CCCGCCCCGCGCCACATGGCC	0.552		NA											22	53					0	0	0	0
FRG2B	441581	broad.mit.edu	37	10	135438781	135438781	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr10:135438781T>C	uc010qvg.1	-	4	712	c.659A>G	c.(658-660)CAG>CGG	p.Q220R		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	220						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GGTCTGCACCTGGGCACACAG	0.597		NA											10	21					0	0	0	0
SIGIRR	59307	broad.mit.edu	37	11	408879	408879	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:408879C>T	uc001lpd.2	-	3	352	c.22G>A	c.(22-24)GCC>ACC	p.A8T	SIGIRR_uc001lpf.2_Missense_Mutation_p.A8T|SIGIRR_uc001lpe.1_Missense_Mutation_p.A8T|SIGIRR_uc001lpg.2_Missense_Mutation_p.A8T	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	8	Extracellular (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGTCAGGGGCCCTATCACAG	0.617		NA											14	48					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1255445	1255445	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:1255445C>A	uc009ycr.1	+	36	4491	c.4365C>A	c.(4363-4365)GCC>GCA	p.A1455A	MUC5B_uc009yct.1_Silent_p.A796A|MUC5B_uc001ltb.2_Silent_p.A799A|MUC5B_uc001lta.2_Silent_p.A464A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	796					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGTGTGCAGCCCCCATGGTGT	0.682		NA											3	6					0.00024832	0.00028114	1	0
MUC5B	727897	broad.mit.edu	37	11	1268010	1268010	+	Silent	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:1268010A>C	uc009ycr.1	+	49	11775	c.11649A>C	c.(11647-11649)CCA>CCC	p.P3883P	MUC5B_uc001ltb.2_Silent_p.P3303P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3300	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCTCCACCCCAGGAACAGCTC	0.637		NA											3	64					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1269681	1269681	+	Silent	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:1269681A>C	uc009ycr.1	+	50	13281	c.13155A>C	c.(13153-13155)CCA>CCC	p.P4385P	MUC5B_uc001ltb.2_Silent_p.P3860P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3857	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTTCCACCCCAGGAACAGCTC	0.647		NA											11	27					0	0	0	0
ZNF195	7748	broad.mit.edu	37	11	3381036	3381036	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:3381036T>C	uc001lxt.2	-	6	1380	c.1202A>G	c.(1201-1203)CAG>CGG	p.Q401R	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Missense_Mutation_p.Q378R|ZNF195_uc001lxs.2_Missense_Mutation_p.Q329R|ZNF195_uc010qxr.1_Missense_Mutation_p.Q382R|ZNF195_uc009ydz.2_Missense_Mutation_p.Q356R|ZNF195_uc001lxu.2_Missense_Mutation_p.Q333R	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	401				Missing (in Ref. 2; BAD18466).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		CTCATTTCTCTGGTGTTTGGA	0.408		NA											81	239					0	0	0	0
HBE1	3046	broad.mit.edu	37	11	5290723	5290723	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:5290723C>A	uc001mal.1	-	2	529	c.276G>T	c.(274-276)CTG>CTT	p.L92L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Silent_p.L92L	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	92					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTCACAGTGCAGCTCACTCA	0.458		NA											33	135					6.53e-20	9.76e-20	1	0
OR51M1	390059	broad.mit.edu	37	11	5411012	5411012	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:5411012C>T	uc010qzc.1	+	1	384	c.384C>T	c.(382-384)CTC>CTT	p.L128L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	128						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTGCTCCTCATGATGTCCT	0.488		NA											82	307					0	0	0	0
OR56A4	120793	broad.mit.edu	37	11	6024019	6024019	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:6024019G>A	uc010qzv.1	-	1	360	c.360C>T	c.(358-360)CTC>CTT	p.L120L		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGGGAGAGGAGGCTGAGCA	0.607		NA											25	85					0	0	0	0
OR2AG2	338755	broad.mit.edu	37	11	6789565	6789565	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:6789565C>A	uc001meq.1	-	1	624	c.624G>T	c.(622-624)TTG>TTT	p.L208F		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAATGGGGAGCAAGAGGAAAG	0.502		NA											10	34					0.00829132	0.00880817	1	0
ANO5	203859	broad.mit.edu	37	11	22294481	22294481	+	Silent	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:22294481A>T	uc001mqi.2	+	19	2498	c.2181A>T	c.(2179-2181)ATA>ATT	p.I727I	ANO5_uc001mqj.2_Silent_p.I726I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	727	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CTCATAGCATAGGTGTTTGGC	0.403		NA											42	144					0	0	0	0
KCNA4	3739	broad.mit.edu	37	11	30033431	30033431	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:30033431G>T	uc001msk.2	-	2	1947	c.795C>A	c.(793-795)GCC>GCA	p.A265A		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	265						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACTTCAACAGGGCCTCCTCCC	0.488		NA											40	103					1.05e-18	1.54e-18	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136727	40136727	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:40136727C>A	uc001mxa.1	-	2	3080	c.1116G>T	c.(1114-1116)GAG>GAT	p.E372D	LRRC4C_uc001mxc.1_Missense_Mutation_p.E368D|LRRC4C_uc001mxd.1_Missense_Mutation_p.E368D|LRRC4C_uc001mxb.1_Missense_Mutation_p.E368D	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	372	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GACATTTCAGCTCAGCTGCCA	0.517		NA											28	60					2.82e-10	3.8e-10	1	0
ALX4	60529	broad.mit.edu	37	11	44296974	44296974	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:44296974T>A	uc001myb.2	-	2	805	c.701A>T	c.(700-702)CAG>CTG	p.Q234L		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	234	Homeobox.				hair follicle development						0						GTGGGTCTTCTGGAAGACCTT	0.617		NA											89	220					0	0	0	0
OR4A5	81318	broad.mit.edu	37	11	51411677	51411678	+	Missense_Mutation	DNP	CC	CC	AA	rs5011055	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:51411677_51411678CC>AA	uc001nhi.1	-	1	718_719	c.718_719GG>TT	c.(718-720)GGC>TTC	p.G240F		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				AACGGTACTGCCGGAGCTGCAG	0.401		NA											5	65					0	0	0	0
OR5L1	219437	broad.mit.edu	37	11	55579236	55579237	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55579236_55579237GG>TT	uc001nhw.1	+	1	294_295	c.294_295GG>TT	c.(292-297)ATGGTG>ATTTTG	p.98_99MV>IL		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	98_99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TAGGGTGCATGGTGCAATTCTA	0.45		NA											29	251					0	0	0	0
OR5D18	219438	broad.mit.edu	37	11	55587970	55587970	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55587970C>A	uc010rin.1	+	1	865	c.865C>A	c.(865-867)CTG>ATG	p.L289M		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GTTGAATCCCCTGATCTACAG	0.458		NA											7	70					8.13e-05	9.38e-05	1	0
OR5L2	26338	broad.mit.edu	37	11	55594988	55594989	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55594988_55594989GG>TT	uc001nhy.1	+	1	294_295	c.294_295GG>TT	c.(292-297)ATGGTG>ATTTTG	p.98_99MV>IL		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	98_99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TAGGGTGCATGGTGCAATTCTA	0.465		NA								HNSCC(27;0.073)			21	129					0	0	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735898	55735898	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:55735898G>A	uc010rit.1	-	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GCATCCAGTGGAGATTGGGAA	0.338		NA											4	75					0	0	0	0
OR8K3	219473	broad.mit.edu	37	11	56085893	56085893	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56085893C>A	uc010rjf.1	+	1	111	c.111C>A	c.(109-111)ATC>ATA	p.I37I		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TCTATGTGATCTCAGTGATGG	0.433		NA											65	119					5.09e-23	7.73e-23	1	0
OR5M3	219482	broad.mit.edu	37	11	56237592	56237592	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56237592G>T	uc010rjk.1	-	1	382	c.382C>A	c.(382-384)CTG>ATG	p.L128M		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CCATAAAGCAGAGGATTCCCA	0.393		NA											35	114					6.34e-27	9.76e-27	1	0
OR5M8	219484	broad.mit.edu	37	11	56258070	56258070	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56258070G>A	uc001nix.1	-	1	777	c.777C>T	c.(775-777)CTC>CTT	p.L259L		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					AGGGGGGTCTGAGATACATGA	0.413		NA											34	59					0	0	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431893	56431893	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56431893C>A	uc010rjm.1	+	1	732	c.732C>A	c.(730-732)CAC>CAA	p.H244Q		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCGGGTCTCACCTTACTGGCA	0.498		NA											40	92					1.3e-30	2.02e-30	1	0
OR9G4	283189	broad.mit.edu	37	11	56510975	56510975	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:56510975T>C	uc010rjo.1	-	1	313	c.313A>G	c.(313-315)AAG>GAG	p.K105E		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	105	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GAAATGCGCTTATCTTCTGAG	0.458		NA											6	125					0	0	0	0
OR4D10	390197	broad.mit.edu	37	11	59245402	59245402	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:59245402C>A	uc001nnz.1	+	1	500	c.500C>A	c.(499-501)CCT>CAT	p.P167H		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CTCCCACTCCCTTTCTGCGGA	0.493		NA											7	145					5.18e-06	6.28e-06	1	0
TCN1	6947	broad.mit.edu	37	11	59622211	59622211	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:59622211T>C	uc001noj.2	-	7	1133	c.1035A>G	c.(1033-1035)ACA>ACG	p.T345T		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	345					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGGTGAAATATGTTTCATTGA	0.408		NA											9	145					0	0	0	0
TPCN2	219931	broad.mit.edu	37	11	68830381	68830381	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:68830381C>A	uc001oos.2	+	6	692	c.576C>A	c.(574-576)CCC>CCA	p.P192P	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Silent_p.P107P|TPCN2_uc010rqg.1_Silent_p.P192P	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	192	Helical; Name=S4 of repeat I; (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTCTCCGTCCCTTCTTCCTGC	0.582		NA											56	162					6.75e-32	1.06e-31	1	0
PHOX2A	401	broad.mit.edu	37	11	71950813	71950813	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:71950813G>T	uc001osh.3	-	3	1007	c.835C>A	c.(835-837)CTG>ATG	p.L279M		NM_005169	NP_005160	O14813	PHX2A_HUMAN	paired-like homeobox 2a	279					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTGGTCTTCAGGGCGGGGCCG	0.692		NA											4	4					0.000602214	0.000669173	1	0
C2CD3	26005	broad.mit.edu	37	11	73753213	73753213	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:73753213T>A	uc001ouu.2	-	29	5773	c.5546A>T	c.(5545-5547)AAC>ATC	p.N1849I	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1849						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CCGGCGAATGTTCTGCACATG	0.433		NA											39	56					0	0	0	0
TMEM135	65084	broad.mit.edu	37	11	87013387	87013387	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:87013387G>A	uc001pch.2	+	8	624	c.601G>A	c.(601-603)GCA>ACA	p.A201T	TMEM135_uc010rtt.1_Missense_Mutation_p.A62T|TMEM135_uc001pci.2_Missense_Mutation_p.A179T	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	201						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTCACCAGAGGCAGCATATGC	0.378		NA											25	57					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	99827584	99827584	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:99827584G>T	uc001pga.2	+	8	1059	c.720G>T	c.(718-720)GCG>GCT	p.A240A	CNTN5_uc009ywv.1_Silent_p.A240A|CNTN5_uc001pfz.2_Silent_p.A240A|CNTN5_uc001pgb.2_Silent_p.A166A	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	240	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCTTTGTGGCGGAAGACAGCC	0.393		NA											17	50					4.97e-08	6.38e-08	1	0
MMP10	4319	broad.mit.edu	37	11	102646043	102646043	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:102646043C>T	uc001phg.1	-	7	964	c.942G>A	c.(940-942)TGG>TGA	p.W314*		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	314	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		GGGATCTTCGCCAAAAATATC	0.328		NA											4	57					0	0	0	0
CASP5	838	broad.mit.edu	37	11	104869720	104869720	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:104869720C>T	uc010rva.1	-	7	1020	c.988G>A	c.(988-990)GCA>ACA	p.A330T	CASP5_uc010ruz.1_Missense_Mutation_p.A343T|CASP5_uc010rvb.1_Missense_Mutation_p.A272T|CASP5_uc010rvc.1_Missense_Mutation_p.A188T|CASP5_uc009yxh.2_Missense_Mutation_p.A112T|CASP5_uc010rvd.1_Missense_Mutation_p.A112T	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	330					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		GCCAAGGATGCTGGAGAGTCT	0.358		NA											26	59					0	0	0	0
AASDHPPT	60496	broad.mit.edu	37	11	105967590	105967590	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:105967590T>C	uc001pjc.1	+	6	1032	c.886T>C	c.(886-888)TGC>CGC	p.C296R	AASDHPPT_uc010rvn.1_RNA|AASDHPPT_uc001pjd.1_Missense_Mutation_p.C149R	NM_015423	NP_056238	Q9NRN7	ADPPT_HUMAN	aminoadipate-semialdehyde	296					macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)		GGACTGTTTTTGCTTCACAGA	0.378		NA											11	48					0	0	0	0
OR10G8	219869	broad.mit.edu	37	11	123900787	123900787	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:123900787T>A	uc001pzp.1	+	1	458	c.458T>A	c.(457-459)CTG>CAG	p.L153Q		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGTGGCTCTCTGCACTCTGCT	0.552		NA											51	115					0	0	0	0
VSIG2	23584	broad.mit.edu	37	11	124617497	124617497	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:124617497G>A	uc001qas.2	-	7	994	c.918C>T	c.(916-918)TTC>TTT	p.F306F		NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	306	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		GTCTTTCCAGGAACCCCTTGC	0.562		NA											6	66					0	0	0	0
ROBO4	54538	broad.mit.edu	37	11	124761626	124761626	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr11:124761626G>C	uc001qbg.2	-	11	1760	c.1620C>G	c.(1618-1620)AGC>AGG	p.S540R	ROBO4_uc010sas.1_Missense_Mutation_p.S395R|ROBO4_uc001qbh.2_Missense_Mutation_p.S430R|ROBO4_uc001qbi.2_Missense_Mutation_p.S98R|ROBO4_uc010sat.1_Missense_Mutation_p.S98R	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	540					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGCTGCTGCTGCTGCTCAGGT	0.662		NA											12	20					0	0	0	0
FGF23	8074	broad.mit.edu	37	12	4479648	4479648	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:4479648C>A	uc001qmq.1	-	3	763	c.617G>T	c.(616-618)TGT>TTT	p.C206F		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	206					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CTCCTGTGAACAGGAGGCCGG	0.706		NA											14	33					0.000308642	0.000347249	1	0
TAS2R50	259296	broad.mit.edu	37	12	11139067	11139067	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:11139067C>T	uc001qzl.2	-	1	445	c.393G>A	c.(391-393)GTG>GTA	p.V131V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	131	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						CCAACAGTATCACCAGAATGA	0.388		NA											80	256					0	0	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717318	13717318	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:13717318G>T	uc001rbt.2	-	13	3033	c.2854C>A	c.(2854-2856)CCG>ACG	p.P952T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	952	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCACAGGGCGGGTTGTTGTAG	0.542		NA											40	94					8.17e-11	1.11e-10	1	0
PTPRO	5800	broad.mit.edu	37	12	15475702	15475702	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:15475702C>A	uc001rcv.1	+	1	216	c.42C>A	c.(40-42)CTC>CTA	p.L14L	PTPRO_uc001rcw.1_Silent_p.L14L|PTPRO_uc001rcu.1_Silent_p.L14L	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	14						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CCCGCCGCCTCCTGCCTCTGC	0.741		NA											10	21					1.15e-07	1.46e-07	1	0
GYS2	2998	broad.mit.edu	37	12	21721901	21721901	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:21721901G>C	uc001rfb.2	-	5	976	c.721C>G	c.(721-723)CGG>GGG	p.R241G		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	241					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATGCAGTACCGGTGGTAAATC	0.433		NA											24	112					0	0	0	0
ABCC9	10060	broad.mit.edu	37	12	22013989	22013989	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:22013989C>T	uc001rfi.1	-	19	2360	c.2340G>A	c.(2338-2340)AGG>AGA	p.R780R	ABCC9_uc001rfh.2_Silent_p.R780R|ABCC9_uc001rfj.1_Silent_p.R744R	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	780	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGCTTTGTACCTTTGGGAGA	0.323		NA											23	99					0	0	0	0
KIAA0528	9847	broad.mit.edu	37	12	22676469	22676469	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:22676469C>A	uc001rfq.2	-	7	919	c.691G>T	c.(691-693)GAG>TAG	p.E231*	KIAA0528_uc010sir.1_Nonsense_Mutation_p.E33*|KIAA0528_uc010sis.1_Nonsense_Mutation_p.E231*|KIAA0528_uc010sit.1_Nonsense_Mutation_p.E231*|KIAA0528_uc010siu.1_Nonsense_Mutation_p.E231*|KIAA0528_uc001rfr.2_Nonsense_Mutation_p.E231*|KIAA0528_uc009ziy.1_Nonsense_Mutation_p.E231*	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	231							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						AACCCAGACTCGCCCTCCAGA	0.473		NA											16	49					2.32e-05	2.73e-05	1	0
BICD1	636	broad.mit.edu	37	12	32480467	32480467	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:32480467G>T	uc001rku.2	+	5	1159	c.1078G>T	c.(1078-1080)GCA>TCA	p.A360S	BICD1_uc001rkv.2_Missense_Mutation_p.A360S|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	360	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CACCAAGGGGGCACTGACGGA	0.562		NA											28	58					1.16e-09	1.55e-09	1	0
MFSD5	84975	broad.mit.edu	37	12	53647566	53647566	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:53647566C>T	uc001sci.1	+	2	1138	c.947C>T	c.(946-948)TCC>TTC	p.S316F	MFSD5_uc001sch.1_Missense_Mutation_p.S423F	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	316	Helical; (Potential).				transport	integral to membrane				skin(2)|ovary(1)	3						CACCTGCTGTCCCTTGCTGTG	0.542		NA											42	105					0	0	0	0
OR9K2	441639	broad.mit.edu	37	12	55523823	55523823	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:55523823C>A	uc010spe.1	+	1	271	c.271C>A	c.(271-273)CTC>ATC	p.L91I		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	91	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						CCTAGGCAATCTCTCCTTCAT	0.408		NA											68	278					2.7e-31	4.21e-31	1	0
OR6C76	390326	broad.mit.edu	37	12	55820376	55820376	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:55820376C>T	uc010spm.1	+	1	339	c.339C>T	c.(337-339)GCC>GCT	p.A113A		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTCCTGGCCTCTATGTCCT	0.413		NA											86	263					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57572180	57572180	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:57572180G>A	uc001snd.2	+	27	4866	c.4400G>A	c.(4399-4401)GGC>GAC	p.G1467D		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1467	Extracellular (Potential).|LDL-receptor class B 11.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GACGGCTCTGGCCACATGGAG	0.582		NA											16	54					0	0	0	0
AGAP2	116986	broad.mit.edu	37	12	58125675	58125676	+	Silent	DNP	GG	GG	TT			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:58125675_58125676GG>TT	uc001spq.2	-	8	1869_1870	c.1869_1870CC>AA	c.(1867-1872)CTCCGA>CTAAGA	p.623_624LR>LR	AGAP2_uc001spp.2_Silent_p.623_624LR>LR|AGAP2_uc001spr.2_Silent_p.287_288LR>LR	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	623_624					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						GCCTCGGCTCGGAGCTCCCGGT	0.609		NA											4	14					0	0	0	0
BEST3	144453	broad.mit.edu	37	12	70049538	70049538	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:70049538C>A	uc001svg.2	-	10	1383	c.1156G>T	c.(1156-1158)GGC>TGC	p.G386C	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.G173C|BEST3_uc010stm.1_Missense_Mutation_p.G280C	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	386	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TGCCGATGGCCATGCTTCTCA	0.547		NA											35	117					2.76e-19	4.09e-19	1	0
TRHDE	29953	broad.mit.edu	37	12	72866900	72866900	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:72866900A>T	uc001sxa.2	+	5	1419	c.1389A>T	c.(1387-1389)GAA>GAT	p.E463D		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	463	Extracellular (Potential).	Zinc; catalytic (By similarity).			cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGCTGAAGGAAGGGTTTGCTC	0.408		NA											41	151					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	72956721	72956721	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:72956721T>C	uc001sxa.2	+	9	1838	c.1808T>C	c.(1807-1809)TTG>TCG	p.L603S		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	603	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						ATCACCATCTTGGGAAACACA	0.338		NA											60	168					0	0	0	0
NAV3	89795	broad.mit.edu	37	12	78444555	78444555	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78444555C>A	uc001syp.2	+	11	2317	c.2144C>A	c.(2143-2145)ACA>AAA	p.T715K	NAV3_uc001syo.2_Missense_Mutation_p.T715K|NAV3_uc010sub.1_Missense_Mutation_p.T215K	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	715						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACCCTGGAGACAACATTTGAC	0.463		NA								HNSCC(70;0.22)			23	96					4.78e-09	6.27e-09	1	0
NAV3	89795	broad.mit.edu	37	12	78444857	78444857	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78444857G>C	uc001syp.2	+	11	2619	c.2446G>C	c.(2446-2448)GAT>CAT	p.D816H	NAV3_uc001syo.2_Missense_Mutation_p.D816H|NAV3_uc010sub.1_Missense_Mutation_p.D316H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	816						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TTCTGAGGTCGATGTGGGTGG	0.493		NA								HNSCC(70;0.22)			12	56					0	0	0	0
NAV3	89795	broad.mit.edu	37	12	78511909	78511909	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78511909G>T	uc001syp.2	+	14	3045	c.2872G>T	c.(2872-2874)GGT>TGT	p.G958C	NAV3_uc001syo.2_Missense_Mutation_p.G958C|NAV3_uc010sub.1_Missense_Mutation_p.G458C|NAV3_uc009zsf.2_5'UTR	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	958						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TGGGGATGCTGGTGGCAAGTG	0.522		NA								HNSCC(70;0.22)			35	138					2.41e-17	3.52e-17	1	0
NAV3	89795	broad.mit.edu	37	12	78562633	78562633	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:78562633C>A	uc001syp.2	+	24	5141	c.4968C>A	c.(4966-4968)GAC>GAA	p.D1656E	NAV3_uc001syo.2_Missense_Mutation_p.D1656E|NAV3_uc010sub.1_Missense_Mutation_p.D1142E|NAV3_uc009zsf.2_Missense_Mutation_p.D487E	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1656						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ATGGTCCAGACCATCCTCCCA	0.378		NA								HNSCC(70;0.22)			27	109					6.33e-13	8.87e-13	1	0
GAS2L3	283431	broad.mit.edu	37	12	101012273	101012273	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:101012273G>C	uc001thu.2	+	8	782	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	GAS2L3_uc009zty.2_Missense_Mutation_p.E186Q|GAS2L3_uc001thv.2_Missense_Mutation_p.E82Q	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	186					cell cycle arrest					skin(1)	1						GAAAGAAATTGAGTTAGAAGA	0.423		NA											26	74					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104044339	104044339	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:104044339G>T	uc001tjw.2	+	11	1426	c.1240G>T	c.(1240-1242)GGA>TGA	p.G414*		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	414	Extracellular (Potential).|FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TACAGACAAGGGACTGAAAGG	0.423		NA											9	31					2.74e-10	3.7e-10	1	0
POLR3B	55703	broad.mit.edu	37	12	106786921	106786921	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:106786921C>T	uc001tlp.2	+	10	1058	c.836C>T	c.(835-837)ACA>ATA	p.T279I	POLR3B_uc001tlq.2_Missense_Mutation_p.T221I	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	279					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						CAGATTTTCACACAGATGCAG	0.458		NA											73	188					0	0	0	0
NAA25	80018	broad.mit.edu	37	12	112491432	112491432	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:112491432A>G	uc001ttm.2	-	15	1678	c.1658T>C	c.(1657-1659)CTA>CCA	p.L553P	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.L525P|NAA25_uc009zwa.1_Missense_Mutation_p.L553P	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	553						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ATACTGACCTAGAGATTCAGC	0.358		NA											9	32					0	0	0	0
TBX5	6910	broad.mit.edu	37	12	114793739	114793739	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:114793739G>T	uc001tvo.2	-	9	1650	c.1155C>A	c.(1153-1155)CCC>CCA	p.P385P	TBX5_uc001tvp.2_Silent_p.P385P|TBX5_uc001tvq.2_Silent_p.P335P	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	385					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GCTCGCTGGGGGGCGCAGAGC	0.632		NA											10	86					7.48e-07	9.26e-07	1	0
DHX37	57647	broad.mit.edu	37	12	125470763	125470763	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:125470763G>A	uc001ugy.2	-	2	254	c.155C>T	c.(154-156)CCG>CTG	p.P52L		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	52							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CTTCTTCCCCGGTAGAACGAG	0.493		NA											50	129					0	0	0	0
GPR133	283383	broad.mit.edu	37	12	131620641	131620641	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:131620641G>A	uc001uit.3	+	22	2886	c.2327G>A	c.(2326-2328)GGC>GAC	p.G776D	GPR133_uc010tbm.1_Missense_Mutation_p.G808D|GPR133_uc009zyo.2_Missense_Mutation_p.G58D|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	776	Helical; Name=6; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGGGTCTTTGGCGTGCTTGCT	0.617		NA											10	48					0	0	0	0
GPR133	283383	broad.mit.edu	37	12	131621519	131621519	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:131621519G>T	uc001uit.3	+	23	2955	c.2396G>T	c.(2395-2397)GGA>GTA	p.G799V	GPR133_uc010tbm.1_Missense_Mutation_p.G831V|GPR133_uc009zyo.2_Missense_Mutation_p.G81V|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	799	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCTTCCCAGGGACTGTTCATA	0.532		NA											19	85					1.85e-09	2.46e-09	1	0
POLE	5426	broad.mit.edu	37	12	133241050	133241050	+	Splice_Site	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:133241050T>A	uc001uks.1	-	22	2513	c.2469_splice	c.e22-1	p.G823_splice	POLE_uc010tbq.1_Splice_Site|POLE_uc009zyu.1_Splice_Site_p.G796_splice	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon						base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CAGCGAGCCCTGAGAGGACAC	0.602		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					16	37					0	0	0	0
RB1	5925	broad.mit.edu	37	13	49033970	49033970	+	Splice_Site	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:49033970G>T	uc001vcb.2	+	20	2272	c.2106_splice	c.e20+1	p.Q702_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTGGACCAAGTAAGAAAATC	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			9	27					7.48e-07	9.26e-07	1	0
MYCBP2	23077	broad.mit.edu	37	13	77633756	77633756	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:77633756G>C	uc001vkf.2	-	78	13019	c.12928C>G	c.(12928-12930)CCC>GCC	p.P4310A	MYCBP2_uc010aev.2_Missense_Mutation_p.P3714A|MYCBP2_uc001vke.2_Missense_Mutation_p.P927A	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTCGTGGTGGGTTTGCCTAGG	0.393		NA											27	69					0	0	0	0
GPC5	2262	broad.mit.edu	37	13	92345593	92345593	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:92345593G>A	uc010tif.1	+	3	844	c.478G>A	c.(478-480)GAA>AAA	p.E160K		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	160						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGTTAATCCTGAAGAATTTGT	0.448		NA											45	99					0	0	0	0
MYO16	23026	broad.mit.edu	37	13	109472729	109472729	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr13:109472729C>A	uc001vqt.1	+	8	972	c.846C>A	c.(844-846)CAC>CAA	p.H282Q	MYO16_uc010agk.1_Missense_Mutation_p.H304Q|MYO16_uc001vqu.1_Missense_Mutation_p.H82Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	282	ANK 7.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CAAACCCACACCTCGTGAACT	0.438		NA											4	18					0.000602214	0.000669173	1	0
OR5AU1	390445	broad.mit.edu	37	14	21623117	21623117	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:21623117C>A	uc010tlp.1	-	1	1068	c.1068G>T	c.(1066-1068)TGG>TGT	p.W356C		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU,	356	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		TTTTCCTACCCCAAACCTTTA	0.428		NA											15	95					4.75e-09	6.24e-09	1	0
CHD8	57680	broad.mit.edu	37	14	21859702	21859702	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:21859702C>T	uc001was.1	-	36	6242	c.6148G>A	c.(6148-6150)GAG>AAG	p.E2050K	CHD8_uc001war.1_Missense_Mutation_p.E1946K	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2329					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GGGGCATCCTCACCCACCAGC	0.557		NA											13	35					0	0	0	0
PNN	5411	broad.mit.edu	37	14	39644596	39644596	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:39644596G>T	uc001wuw.3	+	1	210	c.113G>T	c.(112-114)AGG>ATG	p.R38M		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	38	Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.|Necessary for interactions with KRT8, KRT18 and KRT19.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		AATGACGTGAGGTAAGGGCCT	0.582		NA											6	19					3.6e-05	4.22e-05	1	0
LRFN5	145581	broad.mit.edu	37	14	42356187	42356187	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:42356187G>A	uc001wvm.2	+	3	1557	c.359G>A	c.(358-360)AGT>AAT	p.S120N	LRFN5_uc010ana.2_Missense_Mutation_p.S120N	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	120	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GATATGTTCAGTGGTCTTTCC	0.373		NA								HNSCC(30;0.082)			27	106					0	0	0	0
GNG2	54331	broad.mit.edu	37	14	52433376	52433376	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:52433376G>T	uc001wzi.2	+	4	716	c.187G>T	c.(187-189)GAG>TAG	p.E63*	GNG2_uc001wzh.2_RNA|GNG2_uc010aoc.1_RNA|GNG2_uc001wzj.2_RNA|GNG2_uc001wzk.2_Nonsense_Mutation_p.E63*	NM_053064	NP_444292	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein),	63					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity				0	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	CCCGTTTAGGGAGAAGAAGTT	0.522		NA											56	178					6.61e-23	1e-22	1	0
NID2	22795	broad.mit.edu	37	14	52520339	52520339	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:52520339A>G	uc001wzo.2	-	5	1621	c.1387T>C	c.(1387-1389)TAT>CAT	p.Y463H	NID2_uc010tqs.1_Missense_Mutation_p.Y463H|NID2_uc010tqt.1_Missense_Mutation_p.Y463H|NID2_uc001wzp.2_Missense_Mutation_p.Y463H	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	463						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CCCACCTCATACGTCCCTCGA	0.478		NA											51	155					0	0	0	0
DDHD1	80821	broad.mit.edu	37	14	53518577	53518577	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:53518577T>C	uc001xai.2	-	12	2736	c.2506A>G	c.(2506-2508)AAA>GAA	p.K836E	DDHD1_uc001xaj.2_Intron|DDHD1_uc001xah.2_Intron|DDHD1_uc001xag.2_Intron	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	836	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					GCATTATCTTTATTCTGCATT	0.333		NA											2	14					0	0	0	0
KIAA0586	9786	broad.mit.edu	37	14	58927843	58927843	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:58927843G>T	uc001xdv.3	+	13	2069	c.1796G>T	c.(1795-1797)AGA>ATA	p.R599I	KIAA0586_uc010trr.1_Missense_Mutation_p.R716I|KIAA0586_uc001xdt.3_Missense_Mutation_p.R631I|KIAA0586_uc001xdu.3_Missense_Mutation_p.R660I|KIAA0586_uc010trs.1_Missense_Mutation_p.R590I|KIAA0586_uc010trt.1_Missense_Mutation_p.R535I|KIAA0586_uc010tru.1_Missense_Mutation_p.R535I	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	599										ovary(1)	1						CCTAAGTCCAGACCACAGAGA	0.328		NA											5	16					1.24e-05	1.48e-05	1	0
DACT1	51339	broad.mit.edu	37	14	59112685	59112685	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:59112685G>C	uc001xdw.2	+	4	1508	c.1344G>C	c.(1342-1344)CAG>CAC	p.Q448H	DACT1_uc010trv.1_Missense_Mutation_p.Q167H|DACT1_uc001xdx.2_Missense_Mutation_p.Q411H|DACT1_uc010trw.1_Missense_Mutation_p.Q167H	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	448					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CCGACCTTCAGAGTAAGCACC	0.602		NA											15	43					0	0	0	0
RGS6	9628	broad.mit.edu	37	14	72961932	72961932	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:72961932G>T	uc001xna.3	+	13	1450	c.927G>T	c.(925-927)TGG>TGT	p.W309C	RGS6_uc010ttn.1_Missense_Mutation_p.W309C|RGS6_uc001xmx.3_Missense_Mutation_p.W309C|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.W309C|RGS6_uc010ttp.1_Missense_Mutation_p.W240C|RGS6_uc001xmz.1_Missense_Mutation_p.W170C	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	309	G protein gamma.			W->F: Diminishes interaction with Gbeta5.	G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CCAACCCTTGGATCAGCGATG	0.433		NA											81	201					2.62e-37	4.13e-37	1	0
NRXN3	9369	broad.mit.edu	37	14	79175791	79175791	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:79175791C>A	uc001xun.2	+	4	825	c.334C>A	c.(334-336)CTC>ATC	p.L112I	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.L246I	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	485	Extracellular (Potential).|Laminin G-like 3.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGGCCTGATCCTCTTCACTCA	0.517		NA											54	127					1.88e-15	2.7e-15	1	0
RCOR1	23186	broad.mit.edu	37	14	103188649	103188649	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:103188649G>A	uc001ymb.2	+	11	1306	c.1306G>A	c.(1306-1308)GAA>AAA	p.E436K		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	436					blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						AGTTTTACAAGAATGGGAGGC	0.428		NA											47	135					0	0	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103418843	103418843	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:103418843G>C	uc001ymi.1	-	24	3396	c.3164C>G	c.(3163-3165)GCC>GGC	p.A1055G	CDC42BPB_uc001ymj.1_Missense_Mutation_p.A157G	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1055	Phorbol-ester/DAG-type.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		ACCCTCGCAGGCGTAGCCCTG	0.637		NA											3	27					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24921750	24921750	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:24921750G>C	uc001ywo.2	+	1	1210	c.736G>C	c.(736-738)GCC>CCC	p.A246P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	246					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ACACAGCCAGGCCGGATGTGC	0.622		NA											16	45					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24922585	24922585	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:24922585C>G	uc001ywo.2	+	1	2045	c.1571C>G	c.(1570-1572)CCT>CGT	p.P524R		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	524	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GTGGATTCCCCTCCTCCTCTT	0.547		NA											71	281					0	0	0	0
GABRB3	2562	broad.mit.edu	37	15	26793136	26793136	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:26793136C>A	uc001zaz.2	-	9	1368	c.1226G>T	c.(1225-1227)CGA>CTA	p.R409L	GABRB3_uc010uae.1_Missense_Mutation_p.R324L|GABRB3_uc001zba.2_Missense_Mutation_p.R409L|GABRB3_uc001zbb.2_Missense_Mutation_p.R465L	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	409	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATGCCCTTCTCGAGGCATGCT	0.488		NA											33	93					5.92e-21	8.89e-21	1	0
HERC2	8924	broad.mit.edu	37	15	28388011	28388011	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:28388011T>A	uc001zbj.2	-	75	11612	c.11506A>T	c.(11506-11508)AGG>TGG	p.R3836W		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3836					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTGCCACCCCTCACAATAGGA	0.408		NA											5	17					0	0	0	0
FBN1	2200	broad.mit.edu	37	15	48714173	48714173	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:48714173T>A	uc001zwx.1	-	61	7874	c.7546A>T	c.(7546-7548)ACC>TCC	p.T2516S	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2516	EGF-like 43; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGGTGTTGGGTAAATCCGGGA	0.433		NA											14	47					0	0	0	0
CCPG1	9236	broad.mit.edu	37	15	55669217	55669217	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:55669217T>C	uc002acv.1	-	5	549	c.384A>G	c.(382-384)GCA>GCG	p.A128A	CCPG1_uc002acy.2_Silent_p.A128A|DYX1C1_uc010ugh.1_RNA|CCPG1_uc002acw.1_5'UTR|CCPG1_uc002acx.2_Silent_p.A128A|CCPG1_uc010bfk.1_Silent_p.A128A|CCPG1_uc002acz.1_Silent_p.A128A	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	128	Cytoplasmic (Potential).|Interaction with MCF2L and SRC (By similarity).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		CTGAACTCTGTGCTTCTTCAA	0.388		NA											43	108					0	0	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58287338	58287338	+	Splice_Site	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:58287338C>A	uc002aex.2	-	5	552	c.494_splice	c.e5-1	p.D165_splice	ALDH1A2_uc002aey.2_Splice_Site_p.D165_splice|ALDH1A2_uc010ugv.1_Splice_Site_p.D144_splice|ALDH1A2_uc010ugw.1_Splice_Site_p.D136_splice|ALDH1A2_uc002aew.2_Splice_Site_p.D69_splice	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1						negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TAGTCTCCATCTGAAAGAAAA	0.353		NA											37	108					8.74e-17	1.27e-16	1	0
SLTM	79811	broad.mit.edu	37	15	59182658	59182658	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:59182658C>T	uc002afp.2	-	15	1989	c.1901G>A	c.(1900-1902)CGA>CAA	p.R634Q	SLTM_uc002afn.2_Missense_Mutation_p.R176Q|SLTM_uc002afo.2_Missense_Mutation_p.R616Q|SLTM_uc002afq.2_Missense_Mutation_p.R203Q|SLTM_uc010bgd.2_Missense_Mutation_p.R203Q	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	634	Arg/Glu-rich.|Potential.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						AATCTCTCTTCGTCTACCAAA	0.403		NA											34	128					0	0	0	0
ZNF609	23060	broad.mit.edu	37	15	64967929	64967929	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:64967929C>T	uc002ann.2	+	4	2876	c.2876C>T	c.(2875-2877)TCG>TTG	p.S959L		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	959						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CAGCAGCCCTCGGTCATCCAG	0.507		NA											53	146					0	0	0	0
MAP2K5	5607	broad.mit.edu	37	15	67873100	67873100	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:67873100C>T	uc002aqu.2	+	4	914	c.261C>T	c.(259-261)TCC>TCT	p.S87S	MAP2K5_uc002aqt.1_Silent_p.S87S|MAP2K5_uc002aqv.2_Silent_p.S87S|MAP2K5_uc010ujw.1_Silent_p.S51S	NM_145160	NP_660143	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	87	OPR.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)	2						AGTATTATTCCACAGTAATGG	0.328		NA											41	136					0	0	0	0
HCN4	10021	broad.mit.edu	37	15	73659940	73659940	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:73659940G>A	uc002avp.2	-	1	1666	c.672C>T	c.(670-672)CCC>CCT	p.P224P		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	224	Involved in subunit assembly (By similarity).|Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGTTGACCCCGGGTTGGAGCA	0.652		NA											15	53					0	0	0	0
ACSBG1	23205	broad.mit.edu	37	15	78466037	78466037	+	Missense_Mutation	SNP	C	C	G	rs137988972	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:78466037C>G	uc002bdh.2	-	13	2043	c.1987G>C	c.(1987-1989)GAG>CAG	p.E663Q	ACSBG1_uc010umw.1_Missense_Mutation_p.E659Q|ACSBG1_uc010umx.1_Missense_Mutation_p.E421Q	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	663					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						CGGATCCCCTCTTCGATGGCC	0.577		NA											3	77					0	0	0	0
IREB2	3658	broad.mit.edu	37	15	78780136	78780136	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:78780136G>T	uc002bdr.2	+	14	1933	c.1771G>T	c.(1771-1773)GCA>TCA	p.A591S	IREB2_uc010unb.1_Missense_Mutation_p.A341S	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	591							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		CTTATCAGACGCAGTTTTAAA	0.313		NA											16	86					4.97e-08	6.38e-08	1	0
AGBL1	123624	broad.mit.edu	37	15	87089303	87089303	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:87089303C>G	uc002blz.1	+	19	2698	c.2618C>G	c.(2617-2619)ACC>AGC	p.T873S		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	873					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ATCAAGGAAACCTTGTGGCAA	0.463		NA											7	32					0	0	0	0
IGF1R	3480	broad.mit.edu	37	15	99456390	99456391	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:99456390_99456391TG>AT	uc002bul.2	+	8	1757_1758	c.1707_1708TG>AT	c.(1705-1710)CATGGG>CAATGG	p.569_570HG>QW	IGF1R_uc010urq.1_Missense_Mutation_p.569_570HG>QW|IGF1R_uc010bon.2_Missense_Mutation_p.569_570HG>QW|IGF1R_uc010urr.1_Missense_Mutation_p.19_20HG>QW	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	569_570	Fibronectin type-III 1.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TCTTACTACATGGGCTGAAGCC	0.579		NA											28	65					0	0	0	0
LYSMD4	145748	broad.mit.edu	37	15	100269708	100269708	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr15:100269708T>A	uc002bvk.2	-	3	574	c.511A>T	c.(511-513)AAG>TAG	p.K171*	LYSMD4_uc002bvj.1_Intron|LYSMD4_uc010bou.1_Intron|LYSMD4_uc002bvl.2_Nonsense_Mutation_p.K172*|LYSMD4_uc002bvm.2_3'UTR|LYSMD4_uc010bov.2_Nonsense_Mutation_p.K171*			Q5XG99	LYSM4_HUMAN	SubName: Full=cDNA FLJ77040, highly similar to Homo sapiens LysM, putative peptidoglycan-binding, domain containing 4, mRNA; SubName: Full=LysM, putative peptidoglycan-binding, domain containing 4, isoform CRA_c;	171	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00162)|LUSC - Lung squamous cell carcinoma(107;0.17)|Lung(145;0.208)			TCAATCCCCTTAAAGAAGCCC	0.582		NA											40	103					0	0	0	0
RHOT2	89941	broad.mit.edu	37	16	720765	720765	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:720765G>C	uc002cip.2	+	9	698	c.631G>C	c.(631-633)GCT>CCT	p.A211P	RHOT2_uc002ciq.2_Missense_Mutation_p.A104P|RHOT2_uc010bqy.2_5'Flank	NM_138769	NP_620124	Q8IXI1	MIRO2_HUMAN	ras homolog gene family, member T2	211	EF-hand 1.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			pancreas(1)	1		Hepatocellular(780;0.0218)				AGAGCTCAACGCTTTCCAGGT	0.662		NA											19	39					0	0	0	0
NLRC3	197358	broad.mit.edu	37	16	3614575	3614575	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:3614575G>T	uc010btn.2	-	5	774	c.363C>A	c.(361-363)ACC>ACA	p.T121T		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	121					I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CCAGGGCGACGGTCCTGGCGG	0.706		NA											12	25					1.05e-09	1.41e-09	1	0
LITAF	9516	broad.mit.edu	37	16	11650502	11650502	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:11650502C>A	uc002daz.2	-	2	318	c.85G>T	c.(85-87)GTT>TTT	p.V29F	LITAF_uc002dba.2_Missense_Mutation_p.V29F|LITAF_uc002dbb.2_Missense_Mutation_p.V29F|LITAF_uc002dbc.2_Missense_Mutation_p.V29F|LITAF_uc002dbd.2_Missense_Mutation_p.V29F|LITAF_uc002dbe.3_Missense_Mutation_p.V29F	NM_004862	NP_004853	Q99732	LITAF_HUMAN	lipopolysaccharide-induced TNF-alpha factor	29					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			liver(1)	1						TAACTGTTAACAGCCACTGTC	0.547		NA											27	56					3.8e-20	5.69e-20	1	0
CP110	9738	broad.mit.edu	37	16	19557743	19557743	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:19557743A>C	uc002dgl.3	+	12	3034	c.2787A>C	c.(2785-2787)GAA>GAC	p.E929D	CP110_uc002dgk.3_Missense_Mutation_p.E929D			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	929					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						GAGCTGCTGAAATGGGAATGC	0.303		NA											18	44					0	0	0	0
PDILT	204474	broad.mit.edu	37	16	20410587	20410587	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:20410587G>T	uc002dhc.1	-	2	259	c.36C>A	c.(34-36)GCC>GCA	p.A12A		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	12					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						AGACACAAGCGGCCACCAGCA	0.592		NA											15	103					5.01e-05	5.85e-05	1	0
ACSM2B	348158	broad.mit.edu	37	16	20570737	20570737	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:20570737C>A	uc002dhj.3	-	4	420	c.210G>T	c.(208-210)TGG>TGT	p.W70C	ACSM2B_uc002dhk.3_Missense_Mutation_p.W70C|ACSM2B_uc010bwf.1_Missense_Mutation_p.W70C	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	70					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CATTCACCCACCACAGGGCTG	0.532		NA											8	27					3.86e-05	4.51e-05	1	0
LOC81691	81691	broad.mit.edu	37	16	20824541	20824541	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:20824541T>C	uc002dhv.2	+	3	431	c.168T>C	c.(166-168)ACT>ACC	p.T56T	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Silent_p.T56T|LOC81691_uc002dhw.2_5'UTR|LOC81691_uc002dhy.3_Silent_p.T56T	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	56						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						TTTTATTTACTGACAACTGTG	0.383		NA											23	58					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	21038393	21038393	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:21038393G>A	uc010vbe.1	-	38	5496	c.5496C>T	c.(5494-5496)TTC>TTT	p.F1832F		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1832	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CGGCGGGCTCGAAGATCAGGC	0.572		NA											10	40					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	21117970	21117970	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:21117970C>T	uc010vbe.1	-	15	2125	c.2125G>A	c.(2125-2127)GCA>ACA	p.A709T	DNAH3_uc002die.2_Missense_Mutation_p.A649T	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	709	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACTTTGTCTGCGATGTGGCTG	0.353		NA											17	75					0	0	0	0
RBBP6	5930	broad.mit.edu	37	16	24581745	24581745	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:24581745A>C	uc002dmh.2	+	17	4774	c.3734A>C	c.(3733-3735)GAA>GCA	p.E1245A	RBBP6_uc010vcb.1_Missense_Mutation_p.E1112A|RBBP6_uc002dmi.2_Missense_Mutation_p.E1211A|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.E1078A	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1245					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GTTAAACAAGAAAAAGTCAAA	0.408		NA											16	56					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27556684	27556684	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:27556684T>C	uc002dov.1	-	2	422	c.382A>G	c.(382-384)AGA>GGA	p.R128G	GTF3C1_uc002dou.2_Missense_Mutation_p.R128G	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	128						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GACTTGGTTCTGATGTCATTG	0.418		NA											66	179					0	0	0	0
ZNF668	79759	broad.mit.edu	37	16	31072937	31072937	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:31072937C>A	uc010caf.2	-	3	1669	c.1312G>T	c.(1312-1314)GTG>TTG	p.V438L	ZNF668_uc002eao.2_Missense_Mutation_p.V438L	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						TCACCTGCCACGCCCACAGGC	0.716		NA											26	88					4.03e-09	5.31e-09	1	0
IRX5	10265	broad.mit.edu	37	16	54965210	54965210	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:54965210G>A	uc002ehv.2	+	1	100	c.100G>A	c.(100-102)GAT>AAT	p.D34N	uc010vhb.1_5'Flank|uc010vhc.1_5'Flank|uc002ehu.1_5'Flank|IRX5_uc010cca.1_Missense_Mutation_p.D34N|IRX5_uc002ehw.2_5'Flank	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	34					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						GCCCCGCACGGATGAGCTCGG	0.672		NA											11	22					0	0	0	0
CIRH1A	84916	broad.mit.edu	37	16	69184450	69184450	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:69184450G>T	uc002ews.3	+	7	845	c.749G>T	c.(748-750)AGT>ATT	p.S250I	CIRH1A_uc002ewr.2_Missense_Mutation_p.S250I|CIRH1A_uc002ewt.3_Missense_Mutation_p.S167I|CIRH1A_uc010cfi.2_Missense_Mutation_p.S167I|CIRH1A_uc010cfj.1_Missense_Mutation_p.S69I	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	250	WD 6.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		CAAGAAGACAGTTTCGTGGTG	0.488		NA									OREG0023906	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	152					0.00909568	0.00953133	1	0
NFAT5	10725	broad.mit.edu	37	16	69726060	69726060	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:69726060A>G	uc002exm.1	+	12	3486	c.2278A>G	c.(2278-2280)AAT>GAT	p.N760D	NFAT5_uc002exi.2_Missense_Mutation_p.N684D|NFAT5_uc002exj.1_Missense_Mutation_p.N684D|NFAT5_uc002exk.1_Missense_Mutation_p.N684D|NFAT5_uc002exl.1_Missense_Mutation_p.N778D|NFAT5_uc002exn.1_Missense_Mutation_p.N777D|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	760					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GATTTCATCAAATATTTTTCC	0.443		NA											4	65					0	0	0	0
HSD17B2	3294	broad.mit.edu	37	16	82131825	82131825	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr16:82131825G>A	uc002fgv.2	+	5	1120	c.948G>A	c.(946-948)AAG>AAA	p.K316K		NM_002153	NP_002144	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	316					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2					NADH(DB00157)	TAGCCAGCAAGGACTTCTCTC	0.542		NA											39	73					0	0	0	0
TEKT1	83659	broad.mit.edu	37	17	6718618	6718618	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:6718618G>T	uc002gdt.2	-	5	603	c.493C>A	c.(493-495)CGC>AGC	p.R165S	TEKT1_uc010vth.1_Missense_Mutation_p.R19S	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	165	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				TTGGCAGAGCGGTTCATCCTG	0.498		NA											34	72					8.42e-14	1.19e-13	1	0
SLC2A4	6517	broad.mit.edu	37	17	7188426	7188426	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:7188426C>A	uc002gfp.2	+	9	1240	c.1040C>A	c.(1039-1041)GCG>GAG	p.A347E	SLC2A4_uc002gfo.2_Missense_Mutation_p.A347E|SLC2A4_uc010cmd.2_RNA	NM_001042	NP_001033	P14672	GTR4_HUMAN	glucose transporter 4	347	Cytoplasmic (Potential).				carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding				0						GTGGAGCGGGCGGGGCGCCGG	0.667		NA											10	7					0.000442599	0.000496582	1	0
MFSD6L	162387	broad.mit.edu	37	17	8702310	8702310	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:8702310C>A	uc002glp.1	-	1	277	c.129G>T	c.(127-129)TTG>TTT	p.L43F		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	43						integral to membrane				central_nervous_system(1)	1						AGGGCGCGGCCAAGCCCAGCT	0.652		NA											18	40					1.68e-08	2.19e-08	1	0
GLP2R	9340	broad.mit.edu	37	17	9792733	9792733	+	Missense_Mutation	SNP	G	G	T	rs143908746	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:9792733G>T	uc002gmd.1	+	13	1373	c.1373G>T	c.(1372-1374)CGC>CTC	p.R458L		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	458	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	TTGCTAGCCCGCCACTCAGGC	0.562		NA											16	31					1.37e-15	1.98e-15	1	0
MYH1	4619	broad.mit.edu	37	17	10402013	10402013	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:10402013C>T	uc002gmo.2	-	30	4205	c.4111G>A	c.(4111-4113)GAG>AAG	p.E1371K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1371	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGGGCAACCTCACTGTTGGCC	0.547		NA											49	109					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10427956	10427956	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:10427956G>A	uc010coi.2	-	35	5130	c.5002C>T	c.(5002-5004)CGG>TGG	p.R1668W	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1668W|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1668	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCCTGGCTCCGGAGAGCATCA	0.572		NA											21	50					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10429159	10429159	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:10429159C>T	uc010coi.2	-	31	4350	c.4222G>A	c.(4222-4224)GAA>AAA	p.E1408K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1408K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1408	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCTACATGTTCCTCAGCTGCC	0.483		NA											21	44					0	0	0	0
DNAH9	1770	broad.mit.edu	37	17	11833273	11833273	+	Missense_Mutation	SNP	A	A	T	rs141342607		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:11833273A>T	uc002gne.2	+	63	12036	c.11968A>T	c.(11968-11970)ATG>TTG	p.M3990L	DNAH9_uc010coo.2_Intron|DNAH9_uc002gnf.2_Missense_Mutation_p.M302L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3990	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGGGTCTTCATGAGTGCAGA	0.582		NA											11	21					0	0	0	0
MYOCD	93649	broad.mit.edu	37	17	12649298	12649298	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:12649298C>T	uc002gnn.2	+	9	1333	c.1034C>T	c.(1033-1035)CCC>CTC	p.P345L	MYOCD_uc002gno.2_Missense_Mutation_p.P345L|MYOCD_uc002gnp.1_Missense_Mutation_p.P249L|MYOCD_uc002gnq.2_Missense_Mutation_p.P64L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	345					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGCAATACCCCCTTGTCTCCT	0.423		NA											76	146					0	0	0	0
ZNF286B	729288	broad.mit.edu	37	17	18566461	18566461	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:18566461T>A	uc010vyd.1	-	5	609	c.358A>T	c.(358-360)AGC>TGC	p.S120C		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAATCCTTGCTCTGTGGTCTA	0.388		NA											27	45					0	0	0	0
RAB34	83871	broad.mit.edu	37	17	27041920	27041920	+	Splice_Site	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:27041920T>A	uc002hce.2	-	9	1229	c.605_splice	c.e9-1	p.G202_splice	RAB34_uc002hcg.2_Splice_Site_p.G194_splice|RAB34_uc002hcf.2_Splice_Site_p.G203_splice|RAB34_uc010was.1_Splice_Site_p.G259_splice|RAB34_uc010wat.1_Splice_Site_p.G251_splice|RAB34_uc002hch.2_Splice_Site_p.G202_splice|RAB34_uc010wau.1_Splice_Site_p.G180_splice|RAB34_uc010wav.1_Intron	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1						protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					CATTCTCACCTGACACAGAGA	0.587		NA											12	54					0	0	0	0
KRT12	3859	broad.mit.edu	37	17	39022952	39022952	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:39022952T>A	uc002hvk.2	-	1	511	c.487A>T	c.(487-489)ACA>TCA	p.T163S		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	163	Rod.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GTTCCTCGTGTTTCATACCAT	0.408		NA											54	208					0	0	0	0
HAP1	9001	broad.mit.edu	37	17	39881020	39881020	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:39881020T>C	uc002hxm.1	-	12	1961	c.1949A>G	c.(1948-1950)AAA>AGA	p.K650R	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Missense_Mutation_p.K598R|HAP1_uc002hxo.1_Missense_Mutation_p.K581R|HAP1_uc002hxp.1_Missense_Mutation_p.K573R	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	650					brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GCACTCACCTTTCTGGAGCAT	0.602		NA											57	188					0	0	0	0
LPO	4025	broad.mit.edu	37	17	56344747	56344747	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:56344747G>A	uc002ivt.2	+	12	2047	c.1731G>A	c.(1729-1731)CAG>CAA	p.Q577Q	LPO_uc010wns.1_Silent_p.Q518Q|LPO_uc010dcp.2_Silent_p.Q494Q|LPO_uc010dcq.2_Silent_p.Q248Q|LPO_uc010dcr.2_Silent_p.Q140Q	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	577					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						ACCTCTCACAGCCGCAGACAC	0.552		NA											16	60					0	0	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386506	56386506	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:56386506C>T	uc002ivx.3	-	22	4998	c.4127G>A	c.(4126-4128)AGA>AAA	p.R1376K	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.R1316K|BZRAP1_uc010wnt.1_Missense_Mutation_p.R1376K	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1376						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGGCCAGGTCTTCGGGGCTG	0.587		NA											47	121					0	0	0	0
PRR11	55771	broad.mit.edu	37	17	57270975	57270975	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:57270975C>A	uc002ixf.1	+	5	604	c.525C>A	c.(523-525)CCC>CCA	p.P175P	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	175	Pro-rich.									ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TGCTTCCTCCCACACTGCCAC	0.423		NA											17	32					2.23e-06	2.72e-06	1	0
MED13	9969	broad.mit.edu	37	17	60130054	60130054	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:60130054C>T	uc002izo.2	-	3	391	c.314G>A	c.(313-315)GGA>GAA	p.G105E		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	105					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						CTCCCACACTCCATCTTCTTC	0.338		NA											44	181					0	0	0	0
KCNH6	81033	broad.mit.edu	37	17	61623183	61623183	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:61623183C>A	uc002jay.2	+	14	2985	c.2905C>A	c.(2905-2907)CAC>AAC	p.H969N	KCNH6_uc010wpl.1_Missense_Mutation_p.H810N|KCNH6_uc010wpm.1_Missense_Mutation_p.H933N|KCNH6_uc002jaz.1_Missense_Mutation_p.H880N	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	969	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCTCCCTGAACACCTTGGCTC	0.567		NA											38	130					7e-10	9.4e-10	1	0
APOH	350	broad.mit.edu	37	17	64225441	64225441	+	Silent	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:64225441T>A	uc002jfn.3	-	1	116	c.57A>T	c.(55-57)GCA>GCT	p.A19A		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	19					blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			TACTCCGTCCTGCAATAGCAA	0.363		NA											6	14					0	0	0	0
MAP2K6	5608	broad.mit.edu	37	17	67516411	67516411	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:67516411G>T	uc002jij.2	+	6	655	c.367G>T	c.(367-369)GGT>TGT	p.G123C	MAP2K6_uc002jii.2_Missense_Mutation_p.G123C|MAP2K6_uc002jik.2_3'UTR	NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	123	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					TGGTCTCCAGGGTGATGTGTG	0.343		NA											26	53					1.55e-18	2.29e-18	1	0
RHBDF2	79651	broad.mit.edu	37	17	74473293	74473293	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:74473293G>A	uc002jrq.1	-	8	1269	c.976C>T	c.(976-978)CCT>TCT	p.P326S	RHBDF2_uc002jrp.1_Missense_Mutation_p.P297S|RHBDF2_uc002jrr.1_Missense_Mutation_p.P178S|RHBDF2_uc010wtf.1_Missense_Mutation_p.P297S|RHBDF2_uc002jrs.1_Missense_Mutation_p.P321S	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	326	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						GGGGAGACAGGGGAGGCTGAG	0.632		NA											5	11					0	0	0	0
ENPP7	339221	broad.mit.edu	37	17	77709217	77709217	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:77709217C>A	uc002jxa.2	+	3	795	c.775C>A	c.(775-777)CTG>ATG	p.L259M		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	259					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGCTGGCGACCTGGTTGAATT	0.587		NA											16	86					1.57e-10	2.14e-10	1	0
B3GNTL1	146712	broad.mit.edu	37	17	80972342	80972342	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:80972342C>A	uc002kgg.1	-	5	410	c.396G>T	c.(394-396)CAG>CAT	p.Q132H	B3GNTL1_uc002kgf.1_5'UTR	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	132							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TCGACGGGTGCTGAACGGCAG	0.468		NA											10	56					1.59e-06	1.95e-06	1	0
TMEM200C	645369	broad.mit.edu	37	18	5891898	5891898	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:5891898G>A	uc002kmx.1	-	1	206	c.165C>T	c.(163-165)ATC>ATT	p.I55I		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	55	Helical; (Potential).					integral to membrane					0						CACAGAGGGCGATGAGCCCTG	0.627		NA											13	36					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7079977	7079977	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:7079977T>A	uc002knm.2	-	3	436	c.342A>T	c.(340-342)AGA>AGT	p.R114S	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	114	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTACCTGTCTTAAGTCCA	0.468		NA											13	49					0	0	0	0
MPPE1	65258	broad.mit.edu	37	18	11888679	11888679	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:11888679C>T	uc002kqf.2	-	6	1199	c.558G>A	c.(556-558)TGG>TGA	p.W186*	MPPE1_uc002kqn.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kqg.2_RNA|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_RNA|MPPE1_uc002kqj.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kqk.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kql.2_Nonsense_Mutation_p.W186*|MPPE1_uc002kqm.2_Nonsense_Mutation_p.W186*|MPPE1_uc010dla.1_Nonsense_Mutation_p.W186*	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor	186					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						TAATGCCTTTCCAAGAAAACA	0.353		NA											9	31					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14537970	14537970	+	Missense_Mutation	SNP	C	C	T	rs148283099	by1000genomes	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:14537970C>T	uc010dln.2	-	3	1094	c.640G>A	c.(640-642)GTA>ATA	p.V214I	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	214	ANK 3.									skin(3)	3						TGGCATTGTACGGCCTGTCAG	0.358		NA											6	159					0	0	0	0
FAM59A	64762	broad.mit.edu	37	18	29848468	29848468	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:29848468G>A	uc002kxl.2	-	6	2053	c.1997C>T	c.(1996-1998)CCA>CTA	p.P666L	FAM59A_uc002kxk.1_Missense_Mutation_p.P665L	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	666										ovary(1)|skin(1)	2						AAAAGGTGCTGGGCAGTTTCT	0.532		NA											28	76					0	0	0	0
SLC14A1	6563	broad.mit.edu	37	18	43329784	43329784	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:43329784G>A	uc010xcn.1	+	11	1357	c.1038G>A	c.(1036-1038)ACG>ACA	p.T346T	SLC14A1_uc010dnk.2_Silent_p.T402T|SLC14A1_uc002lbf.3_Silent_p.T346T|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Silent_p.T241T|SLC14A1_uc002lbh.3_Silent_p.T238T|SLC14A1_uc002lbi.3_Silent_p.T214T|SLC14A1_uc002lbj.3_Silent_p.T402T|SLC14A1_uc002lbk.3_Silent_p.T346T	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	346	Helical; (Potential).					integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						GTTTGGCCACGCTATTGTTCC	0.478		NA											48	132					0	0	0	0
TXNL1	9352	broad.mit.edu	37	18	54293689	54293689	+	Splice_Site	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:54293689C>A	uc002lgg.2	-	2	348	c.99_splice	c.e2-1	p.G33_splice	TXNL1_uc010xdz.1_Splice_Site|TXNL1_uc002lgh.2_Splice_Site|TXNL1_uc002lgi.2_Splice_Site_p.G33_splice|TXNL1_uc002lgj.1_Splice_Site_p.G33_splice	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1						cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		TGGCCCACACCTGTTAGAAAA	0.363		NA											40	120					1.6e-16	2.32e-16	1	0
CPLX4	339302	broad.mit.edu	37	18	56985537	56985537	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:56985537A>G	uc002lhy.2	-	1	345	c.158T>C	c.(157-159)ATT>ACT	p.I53T		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	53					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				CTTCTCCTCAATCATTTGCTT	0.408		NA											56	148					0	0	0	0
VPS4B	9525	broad.mit.edu	37	18	61066522	61066522	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:61066522C>T	uc002lix.2	-	8	1085	c.825G>A	c.(823-825)CTG>CTA	p.L275L	VPS4B_uc010dpx.2_Silent_p.L275L|VPS4B_uc010dpy.2_Silent_p.L157L|VPS4B_uc010dpz.1_Silent_p.L157L	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	275					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						TTGTAGCTCCCAGAACCAAAA	0.348		NA											43	100					0	0	0	0
RTTN	25914	broad.mit.edu	37	18	67860629	67860629	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:67860629G>A	uc002lkp.2	-	8	970	c.902C>T	c.(901-903)TCC>TTC	p.S301F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Missense_Mutation_p.S301F	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	301							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				AGGATTCTGGGAATGATGAGT	0.488		NA											21	69					0	0	0	0
C18orf62	284274	broad.mit.edu	37	18	73130849	73130849	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:73130849C>T	uc002lma.1	-	2	223	c.152G>A	c.(151-153)CGT>CAT	p.R51H	C18orf62_uc010dqw.1_Intron|C18orf62_uc002lmb.1_RNA	NM_001037331	NP_001032408	Q3B7S5	CR062_HUMAN	hypothetical protein LOC284274	51	Helical; (Potential).					integral to membrane					0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		OV - Ovarian serous cystadenocarcinoma(15;6.21e-06)		TGTGAAGAAACGAATATGGTG	0.249		NA											32	87					0	0	0	0
GALR1	2587	broad.mit.edu	37	18	74962794	74962794	+	Missense_Mutation	SNP	C	C	A	rs140216881	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr18:74962794C>A	uc002lms.3	+	1	787	c.290C>A	c.(289-291)GCG>GAG	p.A97E		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	97	Extracellular (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		ACCGTGTACGCGCTGCCCACC	0.617		NA											28	128					1.4e-14	1.99e-14	1	0
NCLN	56926	broad.mit.edu	37	19	3207205	3207205	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:3207205G>A	uc002lxi.2	+	13	1663	c.1509G>A	c.(1507-1509)GAG>GAA	p.E503E	NCLN_uc002lxh.1_RNA|NCLN_uc002lxj.1_RNA|NCLN_uc002lxk.2_Silent_p.E147E	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	503	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGACCCAGAGTTTGTCTTCT	0.512		NA											38	114					0	0	0	0
GPR108	56927	broad.mit.edu	37	19	6734313	6734313	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:6734313T>C	uc002mfp.2	-	5	426	c.380A>G	c.(379-381)CAG>CGG	p.Q127R	GPR108_uc010duv.2_5'Flank|GPR108_uc002mfn.2_5'UTR|GPR108_uc002mfo.3_5'UTR|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	127						integral to membrane					0						CTTCCGCACCTGGACCCTGGG	0.637		NA									OREG0025092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	38					0	0	0	0
INSR	3643	broad.mit.edu	37	19	7120658	7120658	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:7120658C>A	uc002mgd.1	-	20	3741	c.3632G>T	c.(3631-3633)GGG>GTG	p.G1211V	INSR_uc002mge.1_Missense_Mutation_p.G1199V	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1211	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTGAAGACCCCATCCTTCAG	0.552		NA											14	51					0.00244969	0.00265821	1	0
ARHGEF18	23370	broad.mit.edu	37	19	7529551	7529551	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:7529551G>A	uc002mgi.2	+	13	2568	c.2315G>A	c.(2314-2316)GGG>GAG	p.G772E	ARHGEF18_uc010xjm.1_Missense_Mutation_p.G614E|ARHGEF18_uc002mgh.2_Missense_Mutation_p.G614E|ARHGEF18_uc002mgj.1_Missense_Mutation_p.G415E	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	772					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GACATTCCTGGGAGCTCTGAG	0.557		NA											16	32					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9085606	9085606	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:9085606G>A	uc002mkp.2	-	1	6413	c.6209C>T	c.(6208-6210)TCT>TTT	p.S2070F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2070	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGTGCCTCAGATAAACTAGT	0.473		NA											67	167					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9088915	9088915	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:9088915C>T	uc002mkp.2	-	1	3104	c.2900G>A	c.(2899-2901)TGG>TAG	p.W967*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	967	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTCTCTGGCCAAGTTGTGCT	0.468		NA											61	235					0	0	0	0
RDH8	50700	broad.mit.edu	37	19	10129427	10129427	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:10129427C>A	uc002mmr.2	+	3	532	c.283C>A	c.(283-285)CTG>ATG	p.L95M		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	95	Helical; (Potential).				estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	TGGAATGGGCCTGGTGGGGCC	0.517		NA											42	245					6.43e-24	9.8e-24	1	0
TYK2	7297	broad.mit.edu	37	19	10464800	10464800	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:10464800C>A	uc002moc.3	-	20	3204	c.2826G>T	c.(2824-2826)TCG>TCT	p.S942S	TYK2_uc010dxe.2_Silent_p.S757S	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	942	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GCTTCCAGCCCGAGCGGTGCT	0.627		NA											34	128					1.22e-17	1.79e-17	1	0
ZNF440	126070	broad.mit.edu	37	19	11942379	11942380	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:11942379_11942380GG>TC	uc002msp.1	+	4	544_545	c.388_389GG>TC	c.(388-390)GGA>TCA	p.G130S		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTGACATTGGACACAAGGCA	0.406		NA											21	221					0	0	0	0
ZNF443	10224	broad.mit.edu	37	19	12542085	12542085	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:12542085T>A	uc002mtu.2	-	4	1099	c.901A>T	c.(901-903)AGA>TGA	p.R301*		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	301	C2H2-type 6.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GTGTGAGTTCTTTCATGTATT	0.408		NA											68	220					0	0	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739139	15739139	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:15739139G>T	uc002nbi.2	+	12	1207	c.1143G>T	c.(1141-1143)CTG>CTT	p.L381L	CYP4F8_uc010xoj.1_Silent_p.L193L	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	381					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGCCCTTCCTGACCATGTGCC	0.617		NA											33	120					6.06e-23	9.2e-23	1	0
CPAMD8	27151	broad.mit.edu	37	19	17015051	17015051	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17015051G>T	uc002nfb.2	-	32	4409	c.4377C>A	c.(4375-4377)GGC>GGA	p.G1459G	CPAMD8_uc002nfd.1_5'Flank	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1412						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TGGAGGAGAAGCCCCCAAGTG	0.652		NA											6	18					5.94e-07	7.37e-07	1	0
ANKLE1	126549	broad.mit.edu	37	19	17394535	17394535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17394535G>A	uc002nga.2	+	5	1238	c.962G>A	c.(961-963)TGG>TAG	p.W321*	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Nonsense_Mutation_p.W343*|ANKLE1_uc010xpn.1_Nonsense_Mutation_p.W375*|ANKLE1_uc002nfy.2_Nonsense_Mutation_p.W310*|ANKLE1_uc002nfz.2_Nonsense_Mutation_p.W27*	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	321						nuclear envelope					0						CACTGCCTGTGGGAGCACCAG	0.612		NA											30	123					0	0	0	0
UNC13A	23025	broad.mit.edu	37	19	17756536	17756536	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17756536G>A	uc002nhd.2	-	19	2567	c.2567C>T	c.(2566-2568)ACG>ATG	p.T856M		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	768	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						CTCAATGATCGTCTGCCCCAG	0.592		NA											4	36					0	0	0	0
JAK3	3718	broad.mit.edu	37	19	17949121	17949121	+	Missense_Mutation	SNP	T	T	A	rs140690573		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17949121T>A	uc002nhn.3	-	11	1620	c.1520A>T	c.(1519-1521)CAG>CTG	p.Q507L	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.Q507L|JAK3_uc010xpx.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	507					B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CTGACTCAGCTGGTATTGGGA	0.547		2	Mis		acute megakaryocytic leukemia|								94	205					0	0	0	0
SLC5A5	6528	broad.mit.edu	37	19	17994720	17994720	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:17994720C>T	uc002nhr.3	+	12	1738	c.1391C>T	c.(1390-1392)ACG>ATG	p.T464M		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	464	Helical; (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TTGGGCGCCACGCTGTACCCA	0.721		NA											5	2					0	0	0	0
IL12RB1	3594	broad.mit.edu	37	19	18182953	18182953	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:18182953C>A	uc002nhw.1	-	9	1054	c.990G>T	c.(988-990)CAG>CAT	p.Q330H	IL12RB1_uc010xqb.1_Missense_Mutation_p.Q330H|IL12RB1_uc002nhx.1_Missense_Mutation_p.Q370H|IL12RB1_uc002nhy.2_Missense_Mutation_p.Q330H	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	330	Extracellular (Potential).|Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TGTGCCACGTCTGGTTCAGGC	0.622		NA											6	32					0.00116845	0.00128078	1	0
ZNF208	7757	broad.mit.edu	37	19	22155424	22155424	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:22155424G>T	uc002nqp.2	-	5	2261	c.2112C>A	c.(2110-2112)CCC>CCA	p.P704P	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CACATTTGTAGGGTTTCTCAT	0.363		NA											29	89					9.81e-20	1.46e-19	1	0
ZNF676	163223	broad.mit.edu	37	19	22363057	22363057	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:22363057T>C	uc002nqs.1	-	3	1780	c.1462A>G	c.(1462-1464)ACG>GCG	p.T488A		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	488	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ATTGAGAACGTACTAAAGCCT	0.413		NA											39	128					0	0	0	0
ZNF676	163223	broad.mit.edu	37	19	22363257	22363257	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:22363257T>G	uc002nqs.1	-	3	1580	c.1262A>C	c.(1261-1263)TAC>TCC	p.Y421S		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	421	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTCACACTTGTAGGGTTTCTC	0.433		NA											41	141					0	0	0	0
DPY19L3	147991	broad.mit.edu	37	19	32899172	32899172	+	Missense_Mutation	SNP	C	C	T	rs143875213		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:32899172C>T	uc002ntg.2	+	2	189	c.13C>T	c.(13-15)CGG>TGG	p.R5W	DPY19L3_uc002ntf.2_Missense_Mutation_p.R5W|DPY19L3_uc002nth.1_Missense_Mutation_p.R5W	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	5						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					GATGTCCATCCGGCAAAGAAG	0.423		NA											15	56					0	0	0	0
MLL4	9757	broad.mit.edu	37	19	36217232	36217232	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:36217232G>T	uc010eei.2	+	15	3981	c.3981G>T	c.(3979-3981)AGG>AGT	p.R1327S		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1327					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTGCCCCAGGTGCACCCAGC	0.592		NA											13	45					1.58e-08	2.07e-08	1	0
ZNF382	84911	broad.mit.edu	37	19	37118348	37118348	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:37118348G>T	uc002oek.2	+	5	1662	c.1549G>T	c.(1549-1551)GAG>TAG	p.E517*	ZNF382_uc010efa.2_Nonsense_Mutation_p.E468*|ZNF382_uc010efb.2_Nonsense_Mutation_p.E516*|ZNF382_uc002oel.2_Nonsense_Mutation_p.E516*	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	517	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCACACAGGCGAGAAACCATA	0.423		NA											19	52					1.02e-10	1.39e-10	1	0
LRFN1	57622	broad.mit.edu	37	19	39798856	39798856	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:39798856C>A	uc002okw.2	-	2	1733	c.1733G>T	c.(1732-1734)CGG>CTG	p.R578L		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	578	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GTGGCTGACCCGCGGGAGCGA	0.697		NA											6	18					0.00116845	0.00128078	1	0
TIMM50	92609	broad.mit.edu	37	19	39972552	39972552	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:39972552T>C	uc002olu.1	+	2	580	c.447T>C	c.(445-447)ACT>ACC	p.T149T	TIMM50_uc002olt.1_RNA	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	46	Mitochondrial matrix (Potential).				mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCGGGAGCACTAAGGCGCAAG	0.632		NA											25	123					0	0	0	0
CEACAM5	1048	broad.mit.edu	37	19	42213713	42213713	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:42213713A>T	uc002ork.2	+	2	300	c.179A>T	c.(178-180)CAG>CTG	p.Q60L	CEACAM5_uc010ehz.1_Missense_Mutation_p.Q60L|CEACAM5_uc002orj.1_Missense_Mutation_p.Q60L|CEACAM5_uc002orl.2_Missense_Mutation_p.Q60L	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	60	Ig-like 1.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		AATCTGCCCCAGCATCTTTTT	0.507		NA											53	142					0	0	0	0
PSG7	5676	broad.mit.edu	37	19	43430641	43430641	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:43430641G>C	uc002ovl.3	-	5	1039	c.937C>G	c.(937-939)CGG>GGG	p.R313G	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.R191G	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	313	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TATCGGTCCCGTATTTCACAT	0.522		NA											6	242					0	0	0	0
CABP5	56344	broad.mit.edu	37	19	48543892	48543892	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:48543892T>C	uc002phu.1	-	3	333	c.208A>G	c.(208-210)ATT>GTT	p.I70V		NM_019855	NP_062829	Q9NP86	CABP5_HUMAN	calcium binding protein 5	70	EF-hand 2.				signal transduction	cytoplasm	calcium ion binding			skin(1)	1		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		CCGAGCTCAATCAGTTCCATC	0.527		NA											18	91					0	0	0	0
NOSIP	51070	broad.mit.edu	37	19	50063282	50063282	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:50063282C>A	uc002pok.2	-	4	237	c.85G>T	c.(85-87)GGG>TGG	p.G29W	NOSIP_uc002pol.2_Missense_Mutation_p.G29W|NOSIP_uc010yay.1_RNA	NM_015953	NP_057037	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	29					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		TTCTGGGTCCCATAGCCCGAG	0.607		NA											8	26					0.000442599	0.000496582	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51919978	51919978	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:51919978A>G	uc002pwo.2	-	3	1264	c.648T>C	c.(646-648)CAT>CAC	p.H216H	SIGLEC10_uc002pwp.2_Silent_p.H158H|SIGLEC10_uc002pwq.2_Silent_p.H158H|SIGLEC10_uc002pwr.2_Silent_p.H216H|SIGLEC10_uc010ycy.1_Silent_p.H216H|SIGLEC10_uc010ycz.1_Silent_p.H168H|SIGLEC10_uc010eow.2_5'UTR|SIGLEC10_uc002pws.1_Silent_p.H142H	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	216	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGAAGTCCACATGGCAGGTGA	0.632		NA											12	41					0	0	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986470	51986470	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:51986470G>A	uc002pwv.1	+	5	1056	c.1056G>A	c.(1054-1056)ATG>ATA	p.M352I		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	352	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGGAGCAGATGGGCCGTTACC	0.557		NA											35	93					0	0	0	0
ZNF610	162963	broad.mit.edu	37	19	52869373	52869373	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:52869373G>T	uc002pyx.3	+	6	1148	c.742G>T	c.(742-744)GTA>TTA	p.V248L	ZNF610_uc002pyy.3_Missense_Mutation_p.V248L|ZNF610_uc002pyz.3_Missense_Mutation_p.V205L|ZNF610_uc002pza.2_Missense_Mutation_p.V248L	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	248	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		TTCACACCTTGTAGAACATTG	0.403		NA											24	56					9.58e-11	1.31e-10	1	0
ZNF677	342926	broad.mit.edu	37	19	53740380	53740380	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:53740380G>A	uc002qbf.1	-	5	1785	c.1600C>T	c.(1600-1602)CAG>TAG	p.Q534*	ZNF677_uc002qbg.1_Nonsense_Mutation_p.Q534*	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	534	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		TGTATTTTCTGGTGTCTAGTG	0.318		NA											23	87					0	0	0	0
PRKCG	5582	broad.mit.edu	37	19	54403966	54403966	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:54403966G>T	uc002qcq.1	+	14	1820	c.1538G>T	c.(1537-1539)CGC>CTC	p.R513L	PRKCG_uc010yeg.1_Missense_Mutation_p.R513L|PRKCG_uc010yeh.1_Missense_Mutation_p.R400L	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	513	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACGACAACCCGCACCTTCTGC	0.567		NA											83	414					6.07e-39	9.6e-39	1	0
CACNG6	59285	broad.mit.edu	37	19	54502939	54502939	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:54502939C>T	uc002qct.2	+	3	1048	c.458C>T	c.(457-459)GCC>GTC	p.A153V	CACNG6_uc002qcu.2_Intron|CACNG6_uc002qcv.2_Intron	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	153	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		GCAGTCATGGCCTTGGGGTGC	0.562		NA											118	347					0	0	0	0
C19orf51	352909	broad.mit.edu	37	19	55677772	55677772	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:55677772G>T	uc002qji.1	-	2	44	c.10C>A	c.(10-12)CCT>ACT	p.P4T	C19orf51_uc002qjj.1_Missense_Mutation_p.P51T|C19orf51_uc002qjk.1_5'UTR|C19orf51_uc002qjl.1_Missense_Mutation_p.P51T			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	4											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GAGCCGGCAGGTGTGGTCATC	0.662		NA									OREG0025679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	46					2.22e-12	3.08e-12	1	0
SBK2	646643	broad.mit.edu	37	19	56042591	56042591	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:56042591A>G	uc010ygc.1	-	2	375	c.375T>C	c.(373-375)ATT>ATC	p.I125I		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	125	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0						ACTCGATGCCAATGCCGTAGG	0.652		NA											10	33					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57325540	57325540	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57325540C>G	uc002qnu.2	-	7	4621	c.4270G>C	c.(4270-4272)GGG>CGG	p.G1424R	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G1395R|PEG3_uc002qnv.2_Missense_Mutation_p.G1424R|PEG3_uc002qnw.2_Missense_Mutation_p.G1300R|PEG3_uc002qnx.2_Missense_Mutation_p.G1298R|PEG3_uc010etr.2_Missense_Mutation_p.G1424R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1424	Glu-rich.|4 X 5 AA repeat of P-X-G-E-A.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCATCTGGCCCTTCAGCCTCT	0.607		NA											18	72					0	0	0	0
USP29	57663	broad.mit.edu	37	19	57641829	57641829	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57641829G>T	uc002qny.2	+	4	2142	c.1786G>T	c.(1786-1788)GAA>TAA	p.E596*		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	596					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTACCCGTTGAACCAGACAA	0.488		NA											19	48					5.39e-06	6.51e-06	1	0
DUXA	503835	broad.mit.edu	37	19	57666725	57666725	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57666725G>T	uc002qoa.1	-	5	499	c.454C>A	c.(454-456)CGA>AGA	p.R152R		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	152	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CTAGATCTTCGATTTTGGAAC	0.383		NA											20	47					1.56e-12	2.18e-12	1	0
ZNF460	10794	broad.mit.edu	37	19	57802666	57802666	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:57802666G>A	uc002qog.2	+	3	1079	c.757G>A	c.(757-759)GTG>ATG	p.V253M	ZNF460_uc010ygv.1_Missense_Mutation_p.V212M	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	253	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TAAGCCCTTTGTGTGCAGTGA	0.542		NA											30	84					0	0	0	0
A1BG	1	broad.mit.edu	37	19	58862906	58862906	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:58862906C>T	uc002qsd.3	-	5	823	c.761G>A	c.(760-762)AGG>AAG	p.R254K	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	254	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		GGTGCTGCTCCTGGGTACCAG	0.627		NA											11	50					0	0	0	0
TPO	7173	broad.mit.edu	37	2	1459848	1459848	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:1459848G>T	uc002qww.2	+	7	704	c.613G>T	c.(613-615)GTC>TTC	p.V205F	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.V205F|TPO_uc002qwr.2_Missense_Mutation_p.V205F|TPO_uc002qwx.2_Missense_Mutation_p.V205F|TPO_uc010yio.1_Missense_Mutation_p.V205F|TPO_uc010yip.1_Missense_Mutation_p.V205F	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	205	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TCCTACCCAGGTCCGGGAGGT	0.493		NA											7	30					0.00198382	0.00215702	1	0
GREB1	9687	broad.mit.edu	37	2	11718542	11718542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:11718542G>T	uc002rbk.1	+	6	1057	c.757G>T	c.(757-759)GGA>TGA	p.G253*	GREB1_uc002rbl.2_Nonsense_Mutation_p.G253*|GREB1_uc002rbm.2_Nonsense_Mutation_p.G143*|GREB1_uc002rbn.1_Nonsense_Mutation_p.G253*	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	253						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CATCCTGATGGGAGCTCAGCA	0.622		NA											24	63					1.11e-12	1.55e-12	1	0
C2orf28	51374	broad.mit.edu	37	2	27438549	27438549	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:27438549A>G	uc002rjf.2	+	5	753	c.580A>G	c.(580-582)ACT>GCT	p.T194A	C2orf28_uc002rjg.2_Missense_Mutation_p.T81A|C2orf28_uc002rjh.2_5'Flank|CAD_uc002rji.2_5'Flank|CAD_uc010eyw.2_5'Flank	NM_080592	NP_542159	Q6UW56	APR3_HUMAN	apoptosis related protein 3 isoform b	139	Extracellular (Potential).					integral to membrane|plasma membrane				skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCCTGGAATACTATCACCTC	0.423		NA											55	137					0	0	0	0
SLC30A3	7781	broad.mit.edu	37	2	27480193	27480193	+	Silent	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:27480193C>G	uc002rjk.2	-	5	792	c.606G>C	c.(604-606)GGG>GGC	p.G202G	SLC30A3_uc002rjj.2_Missense_Mutation_p.G48A|SLC30A3_uc010ylh.1_Silent_p.G197G	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	202	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGGGGGGGCCCAGCCTGGT	0.662		NA											8	17					0	0	0	0
ABCG8	64241	broad.mit.edu	37	2	44079562	44079562	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:44079562C>T	uc002rtq.2	+	5	721	c.631C>T	c.(631-633)CGG>TGG	p.R211W	ABCG8_uc010yoa.1_Missense_Mutation_p.R211W	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	211	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CATGTACGTGCGGGGGTTGTC	0.667		NA											19	44					0	0	0	0
SPTBN1	6711	broad.mit.edu	37	2	54753686	54753686	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:54753686G>T	uc002rxu.2	+	2	380	c.131G>T	c.(130-132)CGC>CTC	p.R44L	SPTBN1_uc002rxv.1_Missense_Mutation_p.R44L|RPL23AP32_uc010yot.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	44	Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GAGCGGTCCCGCATCAAGGCT	0.537		NA											16	42					4.75e-09	6.24e-09	1	0
CTNNA2	1496	broad.mit.edu	37	2	79971585	79971585	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:79971585G>T	uc010ysh.1	+	2	180	c.175G>T	c.(175-177)GTA>TTA	p.V59L	CTNNA2_uc010yse.1_Missense_Mutation_p.V59L|CTNNA2_uc010ysf.1_Missense_Mutation_p.V59L|CTNNA2_uc010ysg.1_Missense_Mutation_p.V59L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	59					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GAAAGCCCATGTACTAGCTGC	0.433		NA											13	38					1.42e-15	2.04e-15	1	0
CTNNA2	1496	broad.mit.edu	37	2	80831210	80831210	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:80831210C>A	uc010ysh.1	+	15	2206	c.2201C>A	c.(2200-2202)CCA>CAA	p.P734Q	CTNNA2_uc010yse.1_Missense_Mutation_p.P734Q|CTNNA2_uc010ysf.1_Missense_Mutation_p.P734Q|CTNNA2_uc010ysg.1_Missense_Mutation_p.P734Q|CTNNA2_uc010ysi.1_Missense_Mutation_p.P366Q|CTNNA2_uc010ysj.1_Missense_Mutation_p.P63Q	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	734					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGCAAAGGCCCATTGAAAAAT	0.408		NA											12	41					1.05e-09	1.41e-09	1	0
ZAP70	7535	broad.mit.edu	37	2	98340653	98340653	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:98340653C>T	uc002syd.1	+	3	361	c.154C>T	c.(154-156)CAC>TAC	p.H52Y	ZAP70_uc010yvf.1_Missense_Mutation_p.H52Y|ZAP70_uc002sye.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	52	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GTCGCTCGTGCACGATGTGCG	0.677		NA											8	8					0	0	0	0
VWA3B	200403	broad.mit.edu	37	2	98851213	98851213	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:98851213C>G	uc002syo.2	+	17	2675	c.2411C>G	c.(2410-2412)ACT>AGT	p.T804S	VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.T323S|VWA3B_uc002sym.2_Missense_Mutation_p.T804S|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.T461S|VWA3B_uc002syp.1_Missense_Mutation_p.T196S|VWA3B_uc002syq.1_Missense_Mutation_p.T80S|VWA3B_uc002syr.1_Missense_Mutation_p.T121S|VWA3B_uc010fih.1_5'Flank	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	804										ovary(3)|large_intestine(2)|skin(1)	6						AGCCGGAGGACTGCTCTAAGT	0.532		NA											18	34					0	0	0	0
NMS	129521	broad.mit.edu	37	2	101098739	101098739	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:101098739C>A	uc002tan.1	+	9	422	c.415C>A	c.(415-417)CCC>ACC	p.P139T		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	139					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						TTTTTTTCAGCCCAGGAATGG	0.423		NA											15	90					1.36e-06	1.67e-06	1	0
IL1RL1	9173	broad.mit.edu	37	2	102955393	102955393	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:102955393C>G	uc002tbu.1	+	3	429	c.158C>G	c.(157-159)ACA>AGA	p.T53R	IL1RL1_uc010ywa.1_Intron|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.T53R	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	53	Extracellular (Potential).|Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TACTCACAAACAAACAAAAGT	0.418		NA											54	231					0	0	0	0
GPR45	11250	broad.mit.edu	37	2	105859167	105859167	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:105859167C>T	uc002tco.1	+	1	968	c.852C>T	c.(850-852)TCC>TCT	p.S284S		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	284	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TGCCCCACTCCGTCTACAGCC	0.587		NA											75	220					0	0	0	0
IL1F8	27177	broad.mit.edu	37	2	113788710	113788710	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:113788710A>G	uc002tiq.1	-	3	140	c.36T>C	c.(34-36)TAT>TAC	p.Y12Y	IL1F8_uc002tir.1_Silent_p.Y12Y	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	12					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						CACGAATAGCATAGGATTTGG	0.463		NA											15	44					0	0	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125285021	125285021	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:125285021G>A	uc002tno.2	+	10	1998	c.1634G>A	c.(1633-1635)AGC>AAC	p.S545N	CNTNAP5_uc010flu.2_Missense_Mutation_p.S546N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	545	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GATCTGTGTAGCATCAAAGAC	0.398		NA											38	120					0	0	0	0
GPR17	2840	broad.mit.edu	37	2	128408390	128408390	+	Silent	SNP	G	G	A	rs145234598		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:128408390G>A	uc010yzn.1	+	4	776	c.165G>A	c.(163-165)ACG>ACA	p.T55T	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.T55T|GPR17_uc010yzo.1_Silent_p.T27T|GPR17_uc002tpd.2_Silent_p.T27T	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	55	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		gccaggagacgccactggaga	0.1		NA									OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	90					0	0	0	0
UBXN4	23190	broad.mit.edu	37	2	136499519	136499519	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:136499519C>G	uc002tur.2	+	1	331	c.20C>G	c.(19-21)GCC>GGC	p.A7G		NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	7	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						TTCCAGGGCGCCATTCCGGCC	0.701		NA											7	23					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141130602	141130602	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:141130602C>A	uc002tvj.1	-	69	11715	c.10743G>T	c.(10741-10743)GGG>GGT	p.G3581G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3581	Extracellular (Potential).|LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTCATCTTCCCCATATTTGC	0.363		NA								TSP Lung(27;0.18)			45	183					1e-16	1.45e-16	1	0
LRP1B	53353	broad.mit.edu	37	2	141460116	141460116	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:141460116C>A	uc002tvj.1	-	38	7002	c.6030G>T	c.(6028-6030)TTG>TTT	p.L2010F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2010	Extracellular (Potential).|LDL-receptor class B 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTCCAGAACAAGAGGCTGA	0.398		NA								TSP Lung(27;0.18)			18	80					2.38e-13	3.34e-13	1	0
MBD5	55777	broad.mit.edu	37	2	149226486	149226486	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:149226486G>T	uc002twm.3	+	9	1962	c.974G>T	c.(973-975)CGA>CTA	p.R325L	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.R325L|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	325						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GAAATACCACGAGCAATGTTC	0.433		NA											23	59					2.89e-11	3.97e-11	1	0
GALNT13	114805	broad.mit.edu	37	2	155102362	155102362	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:155102362G>T	uc002tyr.3	+	7	1291	c.724G>T	c.(724-726)GAT>TAT	p.D242Y	GALNT13_uc002tyt.3_Missense_Mutation_p.D242Y|GALNT13_uc010foc.1_Missense_Mutation_p.D61Y|GALNT13_uc010fod.2_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	242	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TGTGATTAGTGATGATACTTT	0.363		NA											43	142					1.52e-22	2.3e-22	1	0
GALNT13	114805	broad.mit.edu	37	2	155158090	155158090	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:155158090A>T	uc002tyr.3	+	9	1711	c.1144A>T	c.(1144-1146)ATC>TTC	p.I382F	GALNT13_uc002tyt.3_Missense_Mutation_p.I382F|GALNT13_uc010foc.1_Missense_Mutation_p.I201F|GALNT13_uc010fod.2_Missense_Mutation_p.I135F	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	382	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TTTCTTCTACATCATATCCCC	0.353		NA											40	136					0	0	0	0
RBMS1	5937	broad.mit.edu	37	2	161223858	161223858	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:161223858G>A	uc002ubo.2	-	2	564	c.120C>T	c.(118-120)AGC>AGT	p.S40S	RBMS1_uc002ubj.2_Silent_p.S7S|RBMS1_uc002ubk.2_Silent_p.S7S|RBMS1_uc002ubl.2_Silent_p.S38S|RBMS1_uc002ubn.2_Silent_p.S40S|RBMS1_uc002ubi.3_Silent_p.S40S|RBMS1_uc002ubm.2_Silent_p.S7S|RBMS1_uc002ubp.2_Silent_p.S40S|RBMS1_uc010fox.2_Silent_p.S40S	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	40					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						tgctggtggtgctgGGACTGG	0.433		NA											31	74					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	166019249	166019249	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:166019249C>T	uc002ucx.2	-	8	1276	c.784G>A	c.(784-786)GCT>ACT	p.A262T	SCN3A_uc002ucy.2_Missense_Mutation_p.A262T|SCN3A_uc002ucz.2_Missense_Mutation_p.A262T|SCN3A_uc002uda.1_Missense_Mutation_p.A131T|SCN3A_uc002udb.1_Missense_Mutation_p.A131T	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	262	Helical; Name=S5 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CCAATGAGAGCAAACACGCTC	0.483		NA											34	98					0	0	0	0
SCN2A	6326	broad.mit.edu	37	2	166187857	166187857	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:166187857C>G	uc002udc.2	+	14	2457	c.2167C>G	c.(2167-2169)CAG>GAG	p.Q723E	SCN2A_uc002udd.2_Missense_Mutation_p.Q723E|SCN2A_uc002ude.2_Missense_Mutation_p.Q723E	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	723					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGAATCCAGACAGAAATGCCC	0.338		NA											25	92					0	0	0	0
GALNT3	2591	broad.mit.edu	37	2	166606398	166606398	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:166606398C>T	uc010fph.1	-	10	2020	c.1633G>A	c.(1633-1635)GAA>AAA	p.E545K		NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	545	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						GCAGAGTATTCAAAGTACTAT	0.383		NA											33	130					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	170136935	170136935	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:170136935A>G	uc002ues.2	-	11	1479	c.1266T>C	c.(1264-1266)AAT>AAC	p.N422N	LRP2_uc010zdf.1_Silent_p.N422N	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	422	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCACTCCACGATTCTGAGACT	0.448		NA											17	75					0	0	0	0
GPR155	151556	broad.mit.edu	37	2	175326175	175326175	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:175326175G>A	uc002uit.2	-	10	1906	c.1515C>T	c.(1513-1515)CAC>CAT	p.H505H	GPR155_uc002uiu.2_Silent_p.H505H|GPR155_uc002uiv.2_Silent_p.H505H|GPR155_uc010fqs.2_Silent_p.H477H	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	505					intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						TATCTCCATTGTGTTTTCCAG	0.383		NA											43	137					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179437412	179437412	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179437412G>T	uc010zfg.1	-	275	65967	c.65743C>A	c.(65743-65745)CTG>ATG	p.L21915M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L15610M|TTN_uc010zfi.1_Missense_Mutation_p.L15543M|TTN_uc010zfj.1_Missense_Mutation_p.L15418M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22842							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAATAAGCAGGGTGTAAGAG	0.428		NA											38	97					4.33e-17	6.31e-17	1	0
TTN	7273	broad.mit.edu	37	2	179476296	179476296	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179476296T>A	uc010zfg.1	-	218	43180	c.42956A>T	c.(42955-42957)TAC>TTC	p.Y14319F	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Y8014F|TTN_uc010zfi.1_Missense_Mutation_p.Y7947F|TTN_uc010zfj.1_Missense_Mutation_p.Y7822F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15246							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAACATGGTATCCTATGAT	0.438		NA											41	135					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179537416	179537416	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179537416G>T	uc010zfg.1	-	148	31122	c.30898C>A	c.(30898-30900)CCT>ACT	p.P10300T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6961T|TTN_uc010fre.1_Intron|TTN_uc010zfk.1_5'Flank|TTN_uc002una.1_RNA|TTN_uc010frf.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11227							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCCTCAGGAATTTTCTTT	0.373		NA											6	24					1.07e-07	1.36e-07	1	0
TTN	7273	broad.mit.edu	37	2	179588378	179588378	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179588378G>T	uc010zfg.1	-	71	17941	c.17717C>A	c.(17716-17718)CCA>CAA	p.P5906Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P2567Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTTGCCTGGTAGTACTTC	0.433		NA											11	27					0.00829132	0.00880817	1	0
TTN	7273	broad.mit.edu	37	2	179603084	179603084	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179603084G>A	uc010zfg.1	-	46	10588	c.10364C>T	c.(10363-10365)GCC>GTC	p.A3455V	TTN_uc010zfh.1_Missense_Mutation_p.A4528V|TTN_uc010zfi.1_Missense_Mutation_p.A4461V|TTN_uc010zfj.1_Missense_Mutation_p.A4336V|TTN_uc002umz.1_Missense_Mutation_p.A116V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4382							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCACTGGGGCAGCTGCAAA	0.453		NA											11	43					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179605479	179605479	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179605479A>T	uc010zfh.1	-	46	12192	c.11968T>A	c.(11968-11970)TTC>ATC	p.F3990I	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.F3923I|TTN_uc010zfj.1_Missense_Mutation_p.F3798I|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTGGAGAAGGTTTTCTGG	0.448		NA											50	158					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179611115	179611115	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179611115G>T	uc002unb.2	-	46	16236	c.16012C>A	c.(16012-16014)CCT>ACT	p.P5338T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTATGGTCAGGAGTAAATTCG	0.348		NA											21	89					1.02e-10	1.39e-10	1	0
TTN	7273	broad.mit.edu	37	2	179611834	179611834	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179611834G>T	uc002unb.2	-	46	15517	c.15293C>A	c.(15292-15294)CCC>CAC	p.P5098H	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTCCTGGGGGTGTGGAGTA	0.522		NA											41	147					6.24e-21	9.36e-21	1	0
TTN	7273	broad.mit.edu	37	2	179635394	179635394	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:179635394T>C	uc010zfg.1	-	35	8349	c.8125A>G	c.(8125-8127)ATT>GTT	p.I2709V	TTN_uc010zfh.1_Missense_Mutation_p.I2663V|TTN_uc010zfi.1_Missense_Mutation_p.I2663V|TTN_uc010zfj.1_Missense_Mutation_p.I2663V|TTN_uc002unb.2_Missense_Mutation_p.I2709V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2709							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTTCTTAATTTTGACAGCT	0.393		NA											49	129					0	0	0	0
SESTD1	91404	broad.mit.edu	37	2	180014079	180014079	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:180014079C>G	uc002uni.3	-	7	676	c.526G>C	c.(526-528)GAA>CAA	p.E176Q		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	176					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			AAAGCAAGTTCATCTAATAAT	0.289		NA											13	34					0	0	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634252	180634252	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:180634252G>C	uc002unn.3	-	3	835	c.231C>G	c.(229-231)AGC>AGG	p.S77R		NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	77						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TGCTGCTGGGGCTGGCCTGGG	0.607		NA											9	61					0	0	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543323	182543323	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:182543323T>G	uc002uof.2	-	2	501	c.265A>C	c.(265-267)AAG>CAG	p.K89Q	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	89	Poly-Lys.|Nuclear localization signal (Potential).				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GTCATCTTCTTCTTTTTGGGG	0.413		NA											10	37					0	0	0	0
DNAJC10	54431	broad.mit.edu	37	2	183594599	183594600	+	Missense_Mutation	DNP	AG	AG	CT			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:183594599_183594600AG>CT	uc002uow.1	+	8	1073_1074	c.658_659AG>CT	c.(658-660)AGA>CTA	p.R220L	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.R220L|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	220	Thioredoxin 1.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCATGGAGACAGATCAAAGGAG	0.312		NA											26	106					0	0	0	0
CALCRL	10203	broad.mit.edu	37	2	188245205	188245205	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:188245205C>T	uc002upv.3	-	7	945	c.397G>A	c.(397-399)GAG>AAG	p.E133K	CALCRL_uc010frt.2_Missense_Mutation_p.E133K	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	133	Extracellular (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TTCACTTTCTCGTGGGTGTTA	0.338		NA											10	253					0	0	0	0
COL3A1	1281	broad.mit.edu	37	2	189870076	189870076	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:189870076G>T	uc002uqj.1	+	41	3049	c.2932G>T	c.(2932-2934)GGT>TGT	p.G978C		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	978	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTGTATACAGGGTGAAAGTGG	0.413		NA											32	150					1.46e-13	2.06e-13	1	0
SLC40A1	30061	broad.mit.edu	37	2	190430079	190430079	+	Splice_Site	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:190430079C>A	uc002uqp.3	-	6	1111	c.760_splice	c.e6+1	p.D254_splice		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated						anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			GTTCAGTTTACCTTTGTGTAA	0.368		NA											23	49					1.85e-09	2.46e-09	1	0
ANKRD44	91526	broad.mit.edu	37	2	197943433	197943433	+	Silent	SNP	C	C	A	rs146996314		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:197943433C>A	uc002uua.1	-	16	1646	c.1569G>T	c.(1567-1569)CTG>CTT	p.L523L	ANKRD44_uc002utz.3_Silent_p.L255L|ANKRD44_uc002uub.2_Silent_p.L548L|ANKRD44_uc010zgw.1_Silent_p.L476L	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	548	ANK 16.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCACCAATTCCAGACACTGCC	0.418		NA											11	20					0.000219431	0.000251067	1	0
KLF7	8609	broad.mit.edu	37	2	207989096	207989096	+	Silent	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:207989096C>G	uc002vbz.1	-	2	457	c.135G>C	c.(133-135)ACG>ACC	p.T45T	KLF7_uc002vca.1_Silent_p.T45T|KLF7_uc010zix.1_Silent_p.T17T	NM_003709	NP_003700	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	45					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			central_nervous_system(1)|skin(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		TCCGGGGCTCCGTCTGTAGGT	0.557		NA											9	24					0	0	0	0
FN1	2335	broad.mit.edu	37	2	216251534	216251534	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:216251534A>C	uc002vfa.2	-	28	4756	c.4490T>G	c.(4489-4491)GTG>GGG	p.V1497G	FN1_uc002vfb.2_Missense_Mutation_p.V1406G|FN1_uc002vfc.2_Missense_Mutation_p.V1406G|FN1_uc002vfd.2_Missense_Mutation_p.V1497G|FN1_uc002vfe.2_Missense_Mutation_p.V1406G|FN1_uc002vff.2_Missense_Mutation_p.V1406G|FN1_uc002vfg.2_Missense_Mutation_p.V1406G|FN1_uc002vfh.2_Missense_Mutation_p.V1406G|FN1_uc002vfi.2_Missense_Mutation_p.V1497G|FN1_uc002vfj.2_Missense_Mutation_p.V1497G|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Missense_Mutation_p.V124G	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1496	Fibronectin type-III 10.|Cell-attachment.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGTGGGGCACCCGATCTTC	0.542		NA											12	40					0	0	0	0
CUL3	8452	broad.mit.edu	37	2	225400280	225400280	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:225400280C>T	uc002vny.2	-	3	727	c.343G>A	c.(343-345)GCT>ACT	p.A115T	CUL3_uc010zls.1_Missense_Mutation_p.A49T|CUL3_uc010fwy.1_Missense_Mutation_p.A121T	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	115					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATCACCATAGCTGTTTGATGA	0.313		NA											13	35					0	0	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882377	228882377	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:228882377G>T	uc002vpq.2	-	7	3240	c.3193C>A	c.(3193-3195)CCC>ACC	p.P1065T	SPHKAP_uc002vpp.2_Missense_Mutation_p.P1065T|SPHKAP_uc010zlx.1_Missense_Mutation_p.P1065T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1065						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CGATTCCGGGGATAGCCCTGC	0.562		NA											25	45					3.74e-20	5.59e-20	1	0
SP140L	93349	broad.mit.edu	37	2	231249970	231249970	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:231249970G>A	uc010fxm.1	+	9	826	c.735G>A	c.(733-735)TCG>TCA	p.S245S	SP140L_uc010fxo.1_Silent_p.S52S	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	245						nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						AGCTGGTCTCGAGTGAAAAGA	0.458		NA											3	55					0	0	0	0
COL6A3	1293	broad.mit.edu	37	2	238296331	238296331	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:238296331G>T	uc002vwl.2	-	4	1491	c.1206C>A	c.(1204-1206)GTC>GTA	p.V402V	COL6A3_uc002vwo.2_Silent_p.V196V|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Silent_p.V196V|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Silent_p.V402V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	402	VWFA 2.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAATTCCGGGACAGTAAACA	0.542		NA											4	21					0.00909568	0.00953133	1	0
SNPH	9751	broad.mit.edu	37	20	1286353	1286353	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:1286353C>A	uc002wes.2	+	6	1376	c.1140C>A	c.(1138-1140)ACC>ACA	p.T380T	SNPH_uc002wet.2_Silent_p.T424T	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	380					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2						AGCCCATCACCCGTGGACCCA	0.672		NA											13	52					0.00136819	0.00149669	1	0
STK35	140901	broad.mit.edu	37	20	2097588	2097588	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:2097588G>T	uc010gak.2	+	3	1169	c.1169G>T	c.(1168-1170)GGG>GTG	p.G390V	STK35_uc010zpu.1_Intron|STK35_uc002wfw.3_Missense_Mutation_p.G257V	NM_080836	NP_543026	Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	390	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GTCTGTGCTGGGCTGGCACCC	0.542		NA											13	78					2.32e-09	3.07e-09	1	0
SEL1L2	80343	broad.mit.edu	37	20	13868594	13868594	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:13868594C>A	uc010gcf.2	-	7	739	c.657G>T	c.(655-657)ATG>ATT	p.M219I	SEL1L2_uc002woq.3_Missense_Mutation_p.M80I|SEL1L2_uc010zrl.1_Missense_Mutation_p.M219I|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	219	Sel1-like 4.|Extracellular (Potential).					integral to membrane	binding			ovary(2)	2						AAACCAAAATCATCTGGGACA	0.368		NA											17	119					2.94e-08	3.82e-08	1	0
C20orf12	55184	broad.mit.edu	37	20	18377178	18377178	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:18377178T>A	uc010zsa.1	-	15	1815	c.1606A>T	c.(1606-1608)ACT>TCT	p.T536S	C20orf12_uc010zrz.1_Missense_Mutation_p.T55S|C20orf12_uc002wqp.3_Missense_Mutation_p.T227S|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.T403S|C20orf12_uc002wqq.3_Missense_Mutation_p.T517S	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	344						intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				TCGTGGACAGTAGCAGAGATA	0.383		NA											58	90					0	0	0	0
VSX1	30813	broad.mit.edu	37	20	25060074	25060074	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:25060074G>A	uc002wuf.2	-	2	536	c.501C>T	c.(499-501)CAC>CAT	p.H167H	VSX1_uc002wue.2_RNA|VSX1_uc010gdd.1_Silent_p.H167H|VSX1_uc010gde.1_RNA|VSX1_uc010gdf.1_Silent_p.H167H|VSX1_uc002wug.1_Silent_p.H167H	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	167	Homeobox.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCCTATACCTGTGCCGCCGCT	0.557		NA											13	29					0	0	0	0
DLGAP4	22839	broad.mit.edu	37	20	35154397	35154397	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:35154397C>A	uc002xff.2	+	12	3174	c.2739C>A	c.(2737-2739)CCC>CCA	p.P913P	DLGAP4_uc010zvp.1_Silent_p.P913P|DLGAP4_uc002xfg.2_Silent_p.P209P|DLGAP4_uc002xfh.2_Silent_p.P377P|DLGAP4_uc002xfi.2_Silent_p.P222P|DLGAP4_uc002xfj.2_Silent_p.P209P|uc002xfk.3_Intron	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	916					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				TGGAGACCCCCGAGAAGAGGA	0.572		NA											27	85					3.58e-08	4.61e-08	1	0
RBPJL	11317	broad.mit.edu	37	20	43942234	43942234	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:43942234C>A	uc002xns.2	+	7	818	c.746C>A	c.(745-747)ACG>AAG	p.T249K	RBPJL_uc002xnt.2_Missense_Mutation_p.T249K	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	249					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCTGCCTTCACGCTCCACCTG	0.378		NA											11	19					2.81e-09	3.7e-09	1	0
POTEH	23784	broad.mit.edu	37	22	16287846	16287846	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:16287846C>T	uc010gqp.2	-	1	92	c.40G>A	c.(40-42)GTG>ATG	p.V14M	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Translation_Start_Site	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	14										skin(1)	1						GGCTTCTTCACAGAGGAGGCA	0.587		NA											34	70					0	0	0	0
C22orf29	79680	broad.mit.edu	37	22	19839663	19839663	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:19839663G>A	uc002zqg.2	-	2	721	c.122C>T	c.(121-123)CCC>CTC	p.P41L	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Missense_Mutation_p.P41L|C22orf29_uc002zqi.2_Missense_Mutation_p.P41L|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	41											0	Colorectal(54;0.0993)					ATCCACAAGGGGGGTGTATGC	0.617		NA											48	125					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26159210	26159210	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:26159210G>A	uc003abz.1	+	3	302	c.52G>A	c.(52-54)GAC>AAC	p.D18N	MYO18B_uc003aca.1_5'UTR|MYO18B_uc010guy.1_5'UTR|MYO18B_uc010guz.1_5'UTR|MYO18B_uc011aka.1_5'UTR	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	18						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TCGGGAAGAGGACAAGAGCCC	0.542		NA											8	34					0	0	0	0
NCF4	4689	broad.mit.edu	37	22	37273817	37273817	+	Silent	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:37273817G>C	uc003apy.3	+	10	1156	c.972G>C	c.(970-972)CTG>CTC	p.L324L	NCF4_uc003apz.3_3'UTR	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	324					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						CCTGGAAGCTGCACATCACGC	0.607		NA											7	17					0	0	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283742	40283742	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:40283742C>T	uc003ayg.2	-	2	262	c.11G>A	c.(10-12)AGG>AAG	p.R4K		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	4								p.R4K(1)		ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CACTTGTCTCCTGAACGCCAT	0.393		NA											19	62					0	0	0	0
PKDREJ	10343	broad.mit.edu	37	22	46656831	46656831	+	Missense_Mutation	SNP	G	G	T	rs140368137	byFrequency	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:46656831G>T	uc003bhh.2	-	1	2389	c.2389C>A	c.(2389-2391)CGC>AGC	p.R797S		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	797	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GATCGAAAGCGTTTATCTTTT	0.398		NA											32	112					1.08e-15	1.56e-15	1	0
SCO2	9997	broad.mit.edu	37	22	50962505	50962505	+	Silent	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:50962505C>G	uc003bma.2	-	2	512	c.336G>C	c.(334-336)CGG>CGC	p.R112R	SCO2_uc003blz.3_Silent_p.R112R	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	112	Thioredoxin.				cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGCAGCGAGCCCGGCCTCTGT	0.632		NA											10	38					0	0	0	0
CPT1B	1375	broad.mit.edu	37	22	51009711	51009711	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr22:51009711T>G	uc003bmk.3	-	14	1913	c.1751A>C	c.(1750-1752)AAG>ACG	p.K584T	CPT1B_uc003bml.2_Missense_Mutation_p.K584T|CPT1B_uc003bmm.2_Missense_Mutation_p.K584T|CPT1B_uc003bmo.2_Missense_Mutation_p.K584T|CPT1B_uc011asa.1_Missense_Mutation_p.K550T|CPT1B_uc003bmn.2_Missense_Mutation_p.K584T|CPT1B_uc011asb.1_Missense_Mutation_p.K503T|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.K379T|uc003bmr.1_RNA	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	584	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		CAGGCAGAACTTACCCCTGTC	0.602		NA											10	41					0	0	0	0
OXTR	5021	broad.mit.edu	37	3	8809254	8809254	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:8809254G>A	uc003brc.2	-	3	1242	c.620C>T	c.(619-621)GCT>GTT	p.A207V		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	207	Helical; Name=5; (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GATGTAGACAGCTAGCGTGAT	0.612		NA											17	28					0	0	0	0
SLC6A11	6538	broad.mit.edu	37	3	10861414	10861414	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:10861414C>G	uc003bvz.2	+	3	443	c.409C>G	c.(409-411)CAG>GAG	p.Q137E	SLC6A11_uc003bvy.1_Missense_Mutation_p.Q137E	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	137	Helical; Name=3; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CTATGCAACACAGGTGATTGA	0.448		NA											48	112					0	0	0	0
C3orf20	84077	broad.mit.edu	37	3	14755664	14755664	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:14755664C>A	uc003byy.2	+	8	1715	c.1311C>A	c.(1309-1311)ACC>ACA	p.T437T	C3orf20_uc003byz.2_Silent_p.T315T|C3orf20_uc003bza.2_Silent_p.T315T|C3orf20_uc003bzb.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	437						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						ACCTAAAAACCAGGTAAGTGG	0.498		NA											18	33					9.17e-09	1.2e-08	1	0
SH3BP5	9467	broad.mit.edu	37	3	15300345	15300345	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:15300345G>A	uc003bzp.1	-	7	1071	c.882C>T	c.(880-882)GCC>GCT	p.A294A	SH3BP5_uc010hem.1_RNA|SH3BP5_uc003bzq.1_Silent_p.A137A|SH3BP5_uc003bzr.1_Silent_p.A137A|uc003bzo.1_RNA	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	294	Ser-rich.				intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						TACCAGAAATGGCATCAGGCT	0.572		NA											18	37					0	0	0	0
ZNF385D	79750	broad.mit.edu	37	3	21478684	21478684	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:21478684C>A	uc003cce.2	-	5	859	c.451G>T	c.(451-453)GGG>TGG	p.G151W	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	151	Thr-rich.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GCTGGTGTCCCTGCAGTACCG	0.408		NA											35	58					3.09e-21	4.65e-21	1	0
NEK10	152110	broad.mit.edu	37	3	27216146	27216146	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:27216146T>C	uc010hfk.2	-	6	849	c.620A>G	c.(619-621)GAG>GGG	p.E207G	NEK10_uc003cds.1_Missense_Mutation_p.E292G|NEK10_uc010hfj.2_Missense_Mutation_p.E207G			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	895							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						AGTACCTTTCTCAGCATTTTC	0.483		NA											41	103					0	0	0	0
NEK10	152110	broad.mit.edu	37	3	27233635	27233635	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:27233635G>C	uc010hfk.2	-	5	555	c.326C>G	c.(325-327)TCC>TGC	p.S109C	NEK10_uc003cds.1_Missense_Mutation_p.S194C|NEK10_uc010hfj.2_Missense_Mutation_p.S109C			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	797							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GGACAACTGGGATGTAGATAA	0.448		NA											32	73					0	0	0	0
SCN11A	11280	broad.mit.edu	37	3	38921582	38921582	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:38921582G>T	uc011ays.1	-	19	3451	c.3252C>A	c.(3250-3252)CCC>CCA	p.P1084P	SCN11A_uc010hhn.1_Silent_p.P162P	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1084	III.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.P1084P(1)		skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTGGATTTTGGGTTGGTTCT	0.338		NA											13	32					1.36e-13	1.93e-13	1	0
TRAK1	22906	broad.mit.edu	37	3	42132991	42132991	+	Silent	SNP	C	C	G	rs144753843	by1000genomes	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:42132991C>G	uc003cky.2	+	1	246	c.30C>G	c.(28-30)CCC>CCG	p.P10P	TRAK1_uc011azh.1_Silent_p.P10P|TRAK1_uc011azi.1_Silent_p.P10P	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	10					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TCGGGCAGCCCGTCAGGGCTC	0.537		NA											8	40					0	0	0	0
DOCK3	1795	broad.mit.edu	37	3	51263131	51263131	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:51263131G>T	uc011bds.1	+	15	1327	c.1304G>T	c.(1303-1305)AGA>ATA	p.R435I		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	435	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GATTTCGAGAGAGGAGGAAAG	0.463		NA											44	74					7.53e-24	1.15e-23	1	0
GLT8D1	55830	broad.mit.edu	37	3	52734476	52734476	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:52734476T>A	uc003dfi.3	-	2	140	c.1A>T	c.(1-3)ATG>TTG	p.M1L	GLT8D1_uc003dfj.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfk.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfl.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfm.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfn.2_Missense_Mutation_p.M1L|GLT8D1_uc003dfo.1_Missense_Mutation_p.M1L|GLT8D1_uc010hmm.1_RNA	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	1	Cytoplasmic (Potential).					integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGGAATGACATCTTTTTCTTC	0.338		NA											5	115					0	0	0	0
SFMBT1	51460	broad.mit.edu	37	3	52977588	52977588	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:52977588C>A	uc003dgf.2	-	5	714	c.145G>T	c.(145-147)GGA>TGA	p.G49*	SFMBT1_uc010hmr.2_5'UTR|SFMBT1_uc003dgg.2_Nonsense_Mutation_p.G49*|SFMBT1_uc003dgh.2_Nonsense_Mutation_p.G49*	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	49	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GGAGCAAATCCATTTTGCAAA	0.433		NA											33	85					1.22e-17	1.79e-17	1	0
OR5H14	403273	broad.mit.edu	37	3	97868307	97868307	+	Silent	SNP	C	C	A	rs146669592		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:97868307C>A	uc003dsg.1	+	1	78	c.78C>A	c.(76-78)CCC>CCA	p.P26P		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGAAAATACCCCTGTTCCTGG	0.418		NA											162	224					1.82e-84	2.91e-84	1	0
OR5H15	403274	broad.mit.edu	37	3	97887742	97887742	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:97887742G>C	uc011bgu.1	+	1	199	c.199G>C	c.(199-201)GCT>CCT	p.A67P		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGGAATTTAGCTTTTGTGGA	0.403		NA											64	247					0	0	0	0
COL8A1	1295	broad.mit.edu	37	3	99509677	99509677	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:99509677T>C	uc003dtg.1	+	4	396	c.151T>C	c.(151-153)TAC>CAC	p.Y51H	COL8A1_uc003dth.1_Missense_Mutation_p.Y51H|COL8A1_uc003dti.1_Missense_Mutation_p.Y51H	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	51	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						AATTCCACAATACCAGCCCCT	0.537		NA											19	74					0	0	0	0
TRAT1	50852	broad.mit.edu	37	3	108557809	108557809	+	Missense_Mutation	SNP	C	C	A	rs150919761		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:108557809C>A	uc003dxi.1	+	3	291	c.147C>A	c.(145-147)CAC>CAA	p.H49Q	TRAT1_uc010hpx.1_Missense_Mutation_p.H12Q	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	49	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CCAGTGACCACACCAGGTATG	0.318		NA											18	119					6.33e-15	9.05e-15	1	0
MORC1	27136	broad.mit.edu	37	3	108822766	108822766	+	Splice_Site	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:108822766T>A	uc003dxl.2	-	4	242	c.155_splice	c.e4-1	p.V52_splice	MORC1_uc011bhn.1_Splice_Site_p.V52_splice	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1						cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CATTATCCACTGTAAGAGAAA	0.398		NA											45	133					0	0	0	0
DPPA4	55211	broad.mit.edu	37	3	109050622	109050622	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:109050622C>T	uc003dxq.3	-	4	404	c.349G>A	c.(349-351)GCA>ACA	p.A117T	DPPA4_uc011bho.1_Missense_Mutation_p.A117T|DPPA4_uc011bhp.1_Missense_Mutation_p.A117T	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	117						nucleus	protein binding			upper_aerodigestive_tract(1)	1						CGCTTATATGCATCCAATTTC	0.448		NA											30	158					0	0	0	0
SLC9A10	285335	broad.mit.edu	37	3	111870716	111870716	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:111870716A>T	uc003dyu.2	-	28	3734	c.3512T>A	c.(3511-3513)CTA>CAA	p.L1171Q	SLC9A10_uc011bhu.1_Missense_Mutation_p.L434Q|SLC9A10_uc010hqc.2_Missense_Mutation_p.L1123Q	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	1171					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						GACTTTCCTTAGGTTTATTCT	0.522		NA											51	109					0	0	0	0
SLC35A5	55032	broad.mit.edu	37	3	112299779	112299779	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:112299779A>G	uc003dze.2	+	6	1060	c.815A>G	c.(814-816)TAT>TGT	p.Y272C		NM_017945	NP_060415	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	272	Helical; (Potential).					Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1						AGCAAACTCTATTTCTTTGGC	0.388		NA											24	93					0	0	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375785	113375785	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:113375785G>A	uc003eam.2	-	7	5155	c.4744C>T	c.(4744-4746)CCT>TCT	p.P1582S	KIAA2018_uc003eal.2_Missense_Mutation_p.P1526S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1582	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						CTAGTTGAAGGGTTTTCACAG	0.498		NA											43	73					0	0	0	0
ZNF80	7634	broad.mit.edu	37	3	113955434	113955434	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:113955434C>A	uc010hqo.2	-	1	992	c.488G>T	c.(487-489)TGC>TTC	p.C163F	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	163	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				ACATTCTTTGCACCCAAAGAG	0.488		NA											32	190					4.66e-17	6.77e-17	1	0
ADPRH	141	broad.mit.edu	37	3	119305452	119305452	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:119305452G>T	uc003ecs.2	+	4	917	c.619G>T	c.(619-621)GTC>TTC	p.V207F	ADPRH_uc010hqv.2_Missense_Mutation_p.V207F|ADPRH_uc011bjb.1_Missense_Mutation_p.V100F|ADPRH_uc003ect.2_Missense_Mutation_p.V207F	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	207					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		AAAGTACATTGTCCAATCAGG	0.483		NA											36	121					6.03e-25	9.23e-25	1	0
GOLGB1	2804	broad.mit.edu	37	3	121413755	121413755	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:121413755T>G	uc003eei.3	-	13	5726	c.5600A>C	c.(5599-5601)GAA>GCA	p.E1867A	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1872A|GOLGB1_uc003eej.3_Missense_Mutation_p.E1833A|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1753A|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1831A	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1867	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTCTCATTTTCTAAAGTCTG	0.353		NA											87	340					0	0	0	0
PARP9	83666	broad.mit.edu	37	3	122247277	122247277	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:122247277T>C	uc010hri.2	-	11	2644	c.2499A>G	c.(2497-2499)TCA>TCG	p.S833S	PARP9_uc003eff.3_Silent_p.S798S|PARP9_uc011bjs.1_Silent_p.S798S|PARP9_uc003efg.2_Silent_p.S378S|PARP9_uc003efi.2_Silent_p.S798S|PARP9_uc003efh.2_Silent_p.S833S	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	833	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TCATTGGTCCTGATGAGTAAT	0.453		NA											35	136					0	0	0	0
SLC12A8	84561	broad.mit.edu	37	3	124802771	124802771	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:124802771G>T	uc003ehv.3	-	14	2219	c.2108C>A	c.(2107-2109)TCC>TAC	p.S703Y	SLC12A8_uc003ehw.3_Missense_Mutation_p.S732Y|SLC12A8_uc003eht.3_Missense_Mutation_p.S504Y|SLC12A8_uc003ehu.3_Missense_Mutation_p.S456Y|SLC12A8_uc010hry.2_3'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	703					potassium ion transport	integral to membrane	symporter activity				0						GTTCACGAGGGAGGAGTGGTG	0.572		NA											4	32					0.00909568	0.00953133	1	0
CHST13	166012	broad.mit.edu	37	3	126255138	126255138	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:126255138C>A	uc003eja.2	+	2	122	c.122C>A	c.(121-123)TCC>TAC	p.S41Y		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13	41	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		GCCCTGGGCTCCAGCTGGCTT	0.592		NA											21	122					2.28e-19	3.39e-19	1	0
EPHB1	2047	broad.mit.edu	37	3	134825427	134825427	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:134825427C>A	uc003eqt.2	+	4	1163	c.943C>A	c.(943-945)CCA>ACA	p.P315T	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Silent_p.L203L|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	315	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CTTTGACCCTCCAGAAGTGGC	0.587		NA											17	57					5.39e-06	6.51e-06	1	0
STAG1	10274	broad.mit.edu	37	3	136192475	136192475	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:136192475C>A	uc003era.1	-	11	1323	c.1031G>T	c.(1030-1032)GGG>GTG	p.G344V	STAG1_uc003erb.1_Missense_Mutation_p.G344V|STAG1_uc003erc.1_Missense_Mutation_p.G118V|STAG1_uc010hua.1_Missense_Mutation_p.G207V	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	344	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						CCTGACTTCCCCTTGCTTCAG	0.348		NA											10	88					2.81e-09	3.7e-09	1	0
CLSTN2	64084	broad.mit.edu	37	3	140281733	140281733	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:140281733C>A	uc003etn.2	+	14	2483	c.2293C>A	c.(2293-2295)CGG>AGG	p.R765R		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	765	Extracellular (Potential).		R -> Q (in a colorectal cancer sample; somatic mutation).		homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding	p.R765Q(1)		skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCTTGAGGCCCGGCGTTTCCG	0.572		NA								HNSCC(16;0.037)			11	72					3.86e-05	4.51e-05	1	0
TRPC1	7220	broad.mit.edu	37	3	142522827	142522827	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:142522827G>T	uc003evc.2	+	11	1902	c.1766G>T	c.(1765-1767)GGC>GTC	p.G589V	TRPC1_uc003evb.2_Missense_Mutation_p.G555V|TRPC1_uc011bni.1_Missense_Mutation_p.G108V	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	589	Helical; (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AGGTTCATTGGCACCTGCTTT	0.328		NA											22	108					1.11e-09	1.48e-09	1	0
PLOD2	5352	broad.mit.edu	37	3	145799596	145799596	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:145799596C>A	uc003evs.1	-	12	1793	c.1287G>T	c.(1285-1287)TGG>TGT	p.W429C	PLOD2_uc003evq.1_Missense_Mutation_p.W89C|PLOD2_uc011bnm.1_Missense_Mutation_p.W374C|PLOD2_uc003evr.1_Missense_Mutation_p.W429C	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	429					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TCAATGCTCCCCAGAAATTGG	0.378		NA											15	106					2.32e-09	3.07e-09	1	0
ZIC4	84107	broad.mit.edu	37	3	147114163	147114163	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147114163G>T	uc003ewd.1	-	3	437	c.164C>A	c.(163-165)CCC>CAC	p.P55H	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.P105H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	55						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AGGACGGCTGGGGGAGGCCTG	0.716		NA											10	38					1.59e-06	1.95e-06	1	0
ZIC1	7545	broad.mit.edu	37	3	147130344	147130344	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147130344G>C	uc003ewe.2	+	2	1741	c.1022G>C	c.(1021-1023)CGG>CCG	p.R341P		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	341	C2H2-type 4.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGCTGTGACCGGCGCTTCGCT	0.532		NA											29	117					0	0	0	0
ZIC1	7545	broad.mit.edu	37	3	147131168	147131168	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147131168C>T	uc003ewe.2	+	3	1893	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	392	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCAGGGCTCGCAGCCTTCGCC	0.622		NA											21	147					0	0	0	0
ZIC1	7545	broad.mit.edu	37	3	147131266	147131266	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:147131266C>A	uc003ewe.2	+	3	1991	c.1272C>A	c.(1270-1272)CCC>CCA	p.P424P		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	424	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCTTATCGCCCTCCTCCTCCG	0.562		NA											25	163					4.72e-08	6.08e-08	1	0
TSC22D2	9819	broad.mit.edu	37	3	150128674	150128674	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:150128674G>T	uc003exv.2	+	1	1887	c.1537G>T	c.(1537-1539)GTG>TTG	p.V513L	TSC22D2_uc003exw.2_RNA|TSC22D2_uc003exx.2_Missense_Mutation_p.V513L	NM_014779	NP_055594	O75157	T22D2_HUMAN	TSC22 domain family, member 2	513							sequence-specific DNA binding transcription factor activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GCCTGCAGCCGTGCCCGCTCC	0.647		NA											8	55					2.18e-05	2.57e-05	1	0
MED12L	116931	broad.mit.edu	37	3	151067863	151067863	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:151067863A>T	uc003eyp.2	+	15	2200	c.2162A>T	c.(2161-2163)CAT>CTT	p.H721L	MED12L_uc011bnz.1_Missense_Mutation_p.H581L|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	721					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTTCAAGTCATGAATGTAAC	0.433		NA											100	592					0	0	0	0
MME	4311	broad.mit.edu	37	3	154861232	154861232	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:154861232G>T	uc010hvr.1	+	13	1400	c.1189G>T	c.(1189-1191)GCC>TCC	p.A397S	MME_uc003fab.1_Missense_Mutation_p.A397S|MME_uc003fac.1_Missense_Mutation_p.A397S|MME_uc003fad.1_Missense_Mutation_p.A397S|MME_uc003fae.1_Missense_Mutation_p.A397S	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	397	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTTTCCGTAGGCCCTTTATGG	0.418		NA											29	219					1.75e-13	2.47e-13	1	0
IL12A	3592	broad.mit.edu	37	3	159711264	159711264	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:159711264G>A	uc003fcx.2	+	4	620	c.405G>A	c.(403-405)GAG>GAA	p.E135E	uc003fcw.1_Intron	NM_000882	NP_000873	P29459	IL12A_HUMAN	interleukin 12A precursor	101					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ATTCCAGAGAGACCTCTTTCA	0.313		NA											10	100					0	0	0	0
IFT80	57560	broad.mit.edu	37	3	160037641	160037641	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:160037641A>G	uc011boy.1	-	9	1297	c.864T>C	c.(862-864)TGT>TGC	p.C288C	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Silent_p.C151C|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_Silent_p.C151C	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	288	WD 6.					cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTCCATTTCCACAGGCTCCAG	0.408		NA											45	145					0	0	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906635	164906635	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:164906635C>A	uc003fej.3	-	2	2428	c.1984G>T	c.(1984-1986)GTT>TTT	p.V662F	SLITRK3_uc003fek.2_Missense_Mutation_p.V662F	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	662	Helical; (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						AAAAACAGAACCAGCAGGCTG	0.527		NA								HNSCC(40;0.11)			15	52					1.36e-06	1.67e-06	1	0
WDR49	151790	broad.mit.edu	37	3	167272580	167272580	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:167272580C>T	uc003fev.1	-	6	964	c.658G>A	c.(658-660)GAC>AAC	p.D220N	WDR49_uc003feu.1_Missense_Mutation_p.D45N|WDR49_uc011bpd.1_Missense_Mutation_p.D273N|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	220	WD 4.									large_intestine(1)|ovary(1)|skin(1)	3						CCATTGAAGTCCCATATCTTT	0.323		NA											56	219					0	0	0	0
SAMD7	344658	broad.mit.edu	37	3	169639112	169639112	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:169639112G>A	uc003fgd.2	+	4	464	c.197G>A	c.(196-198)AGT>AAT	p.S66N	SAMD7_uc003fge.2_Missense_Mutation_p.S66N|SAMD7_uc011bpo.1_5'UTR	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	66										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GTGTTGTCCAGTCGGATCTAC	0.438		NA											35	185					0	0	0	0
FNDC3B	64778	broad.mit.edu	37	3	172046816	172046816	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:172046816G>T	uc003fhy.2	+	12	1501	c.1329G>T	c.(1327-1329)CCG>CCT	p.P443P	FNDC3B_uc003fhz.3_Silent_p.P443P|FNDC3B_uc003fia.2_Silent_p.P374P	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	443	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AGCTTTGTCCGGCAATGGGGT	0.473		NA											29	164					2.48e-08	3.22e-08	1	0
PIK3CA	5290	broad.mit.edu	37	3	178948139	178948139	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:178948139T>C	uc003fjk.2	+	20	3068	c.2911T>C	c.(2911-2913)TGC>CGC	p.C971R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	971	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGCCCAAGAATGCACAAAGAC	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			21	124					0	0	0	0
TTC14	151613	broad.mit.edu	37	3	180321002	180321002	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:180321002G>T	uc003fkk.2	+	3	509	c.377G>T	c.(376-378)GGT>GTT	p.G126V	TTC14_uc003fkl.2_Missense_Mutation_p.G126V|TTC14_uc003fkm.2_Missense_Mutation_p.G126V	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	126	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATTGAGCGTGGTGATATAGTG	0.378		NA											43	245					4.67e-22	7.03e-22	1	0
B3GNT5	84002	broad.mit.edu	37	3	182987805	182987805	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:182987805C>T	uc003flk.2	+	2	749	c.219C>T	c.(217-219)TAC>TAT	p.Y73Y	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Silent_p.Y73Y|B3GNT5_uc003flm.2_Silent_p.Y73Y	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	73	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GGCCTCGCTACCAATACTTGA	0.418		NA											39	159					0	0	0	0
HTR3E	285242	broad.mit.edu	37	3	183824076	183824076	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:183824076C>A	uc010hxq.2	+	8	1552	c.1086C>A	c.(1084-1086)CCC>CCA	p.P362P	HTR3E_uc003fml.3_Silent_p.P347P|HTR3E_uc003fmm.2_Silent_p.P377P|HTR3E_uc010hxr.2_Silent_p.P388P|HTR3E_uc003fmn.2_Silent_p.P362P	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	362	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GATGCTGTCCCACTGCGCCCC	0.577		NA											12	60					0.000978159	0.00108025	1	0
TBCCD1	55171	broad.mit.edu	37	3	186272075	186272075	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:186272075C>A	uc003fqg.2	-	6	1641	c.1512G>T	c.(1510-1512)TGG>TGT	p.W504C	TBCCD1_uc011bry.1_Missense_Mutation_p.W504C|TBCCD1_uc003fqh.2_Missense_Mutation_p.W408C	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	504					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		CAGTTTTCTGCCAGATCTGTA	0.408		NA											45	246					1.42e-22	2.14e-22	1	0
ATP13A3	79572	broad.mit.edu	37	3	194149640	194149640	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:194149640T>G	uc003fty.3	-	27	3283	c.2881A>C	c.(2881-2883)AGT>CGT	p.S961R		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	961	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CCTAGGTTACTTAAGATCTAC	0.294		NA											16	66					0	0	0	0
TMEM44	93109	broad.mit.edu	37	3	194336360	194336360	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:194336360T>A	uc010hzn.2	-	8	1160	c.991A>T	c.(991-993)AGA>TGA	p.R331*	TMEM44_uc010hzm.2_Nonsense_Mutation_p.R16*|TMEM44_uc003fuc.2_Nonsense_Mutation_p.R16*|TMEM44_uc003fue.2_Nonsense_Mutation_p.R284*|TMEM44_uc003fud.2_Nonsense_Mutation_p.R284*|TMEM44_uc003fuf.2_Nonsense_Mutation_p.R284*|TMEM44_uc011bsv.1_Nonsense_Mutation_p.R284*|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	331	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		GGGCTCTCTCTGGCTTCCTTG	0.478		NA											104	390					0	0	0	0
UBXN7	26043	broad.mit.edu	37	3	196129879	196129879	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:196129879C>T	uc003fwm.3	-	3	308	c.233G>A	c.(232-234)CGT>CAT	p.R78H	UBXN7_uc003fwn.3_Translation_Start_Site|UBXN7_uc010iae.2_Intron|UBXN7_uc010iaf.2_Missense_Mutation_p.R78H	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	78							protein binding			ovary(2)|pancreas(1)	3						AATTGGGGCACGAACTTCTTC	0.318		NA											56	373					0	0	0	0
IQCG	84223	broad.mit.edu	37	3	197665493	197665493	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:197665493C>T	uc003fyo.2	-	4	587	c.441G>A	c.(439-441)CAG>CAA	p.Q147Q	IQCG_uc003fyn.2_Silent_p.Q49Q|IQCG_uc003fyp.2_Silent_p.Q147Q|IQCG_uc003fyq.3_Silent_p.Q147Q	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	147											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		AGACAAGATCCTGCATTTTGT	0.433		NA											120	654					0	0	0	0
ZNF595	152687	broad.mit.edu	37	4	59410	59410	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:59410G>T	uc003fzv.1	+	2	247	c.91G>T	c.(91-93)GAT>TAT	p.D31Y	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Missense_Mutation_p.D31Y|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	31					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TTTGTATAGAGATGTGATGTT	0.423		NA											37	831					5.72e-15	8.18e-15	1	0
ZFYVE28	57732	broad.mit.edu	37	4	2306180	2306180	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:2306180G>T	uc003gex.1	-	8	2206	c.1887C>A	c.(1885-1887)CCC>CCA	p.P629P	ZFYVE28_uc011bvk.1_Silent_p.P559P|ZFYVE28_uc011bvl.1_Silent_p.P599P|ZFYVE28_uc003gew.1_Silent_p.P515P	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	629					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						TGTCGGAAGTGGGGGCTTTGG	0.667		NA											36	71					6.05e-29	9.37e-29	1	0
YIPF7	285525	broad.mit.edu	37	4	44626780	44626780	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:44626780C>G	uc010ifx.1	-	5	535	c.518G>C	c.(517-519)GGT>GCT	p.G173A		NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	173	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0						ATACACATAACCAAACTGAAC	0.478		NA											4	3					0	0	0	0
NFXL1	152518	broad.mit.edu	37	4	47877297	47877297	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:47877297C>T	uc010igh.2	-	18	2270	c.2093G>A	c.(2092-2094)TGC>TAC	p.C698Y	NFXL1_uc003gxo.2_Missense_Mutation_p.C23Y|NFXL1_uc003gxp.2_Missense_Mutation_p.C698Y|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Missense_Mutation_p.C698Y	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	698	NF-X1-type 8.					integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						ACAATGAAGGCATTCTGGGCC	0.428		NA											12	75					0	0	0	0
SPATA18	132671	broad.mit.edu	37	4	52917908	52917908	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:52917908C>G	uc003gzl.2	+	1	316	c.38C>G	c.(37-39)ACT>AGT	p.T13S	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.T13S|SPATA18_uc003gzk.1_Missense_Mutation_p.T13S	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	13					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCAAACGAAACTTTACGAACG	0.567		NA											40	236					0	0	0	0
KDR	3791	broad.mit.edu	37	4	55968085	55968085	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:55968085C>T	uc003has.2	-	15	2547	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	KDR_uc003hat.1_Missense_Mutation_p.E749K	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	749	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AAAAATGCCTCCACTTTTGCA	0.333		NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			77	80					0	0	0	0
PROL1	58503	broad.mit.edu	37	4	71275727	71275727	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:71275727C>T	uc003hfi.2	+	3	856	c.682C>T	c.(682-684)CAA>TAA	p.Q228*		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	228	Thr-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				GACTTCCAACCAAACTATATT	0.408		NA											26	68					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73968234	73968234	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:73968234C>T	uc003hgp.2	-	25	4549	c.4432G>A	c.(4432-4434)GCT>ACT	p.A1478T	ANKRD17_uc003hgo.2_Missense_Mutation_p.A1365T|ANKRD17_uc003hgq.2_Missense_Mutation_p.A1227T|ANKRD17_uc003hgr.2_Missense_Mutation_p.A1477T	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1478	Potential.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			cttttcGCAGCCAAAGCCAGC	0.264		NA											11	41					0	0	0	0
NUP54	53371	broad.mit.edu	37	4	77053715	77053715	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:77053715G>T	uc003hjs.2	-	6	996	c.868C>A	c.(868-870)CCT>ACT	p.P290T	NUP54_uc010ije.2_Missense_Mutation_p.P8T|NUP54_uc011cbs.1_Missense_Mutation_p.P110T|NUP54_uc011cbt.1_Missense_Mutation_p.P242T|NUP54_uc003hjt.2_Missense_Mutation_p.P110T	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	290	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						ATCTGTGCAGGAGAAAGTTCT	0.383		NA											9	224					1.62e-10	2.19e-10	1	0
CCDC158	339965	broad.mit.edu	37	4	77283402	77283402	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:77283402C>A	uc003hkb.3	-	12	2050	c.1897G>T	c.(1897-1899)GAA>TAA	p.E633*		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	633	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TTCACCTTTTCCAGCTCCAAG	0.408		NA											7	239					0.00448238	0.00482833	1	0
ANXA3	306	broad.mit.edu	37	4	79500196	79500196	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:79500196T>C	uc003hld.2	+	4	429	c.119T>C	c.(118-120)ATG>ACG	p.M40T	ANXA3_uc003hle.2_Missense_Mutation_p.M1T|ANXA3_uc010ijk.2_Missense_Mutation_p.M1T	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	40	Annexin 1.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						GATGAGAAAATGCTCATCAGC	0.368		NA											17	30					0	0	0	0
WDFY3	23001	broad.mit.edu	37	4	85600085	85600085	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:85600085G>A	uc003hpd.2	-	65	10542	c.10134C>T	c.(10132-10134)AGC>AGT	p.S3378S	WDFY3_uc003hpc.2_Silent_p.S133S	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3378						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GTTTCAATCTGCTGTAATTCC	0.517		NA											40	89					0	0	0	0
DMP1	1758	broad.mit.edu	37	4	88583240	88583240	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:88583240G>A	uc003hqv.2	+	6	414	c.310G>A	c.(310-312)GAC>AAC	p.D104N	DMP1_uc003hqw.2_Missense_Mutation_p.D88N	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	104					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TGATAAAGATGACGATGAAGA	0.502		NA											8	27					0	0	0	0
CENPE	1062	broad.mit.edu	37	4	104062227	104062227	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:104062227A>G	uc003hxb.1	-	36	5588	c.5498T>C	c.(5497-5499)ATT>ACT	p.I1833T	CENPE_uc003hxc.1_Missense_Mutation_p.I1808T|CENPE_uc003hxd.1_5'Flank	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1833	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTTAACGTAATAAGTTGATG	0.279		NA											9	31					0	0	0	0
ENPEP	2028	broad.mit.edu	37	4	111397696	111397696	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:111397696G>A	uc003iab.3	+	1	468	c.126G>A	c.(124-126)TCG>TCA	p.S42S		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	42	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TGACCAGATCGTGTGACTCCA	0.612		NA											9	156					0	0	0	0
PRDM5	11107	broad.mit.edu	37	4	121828688	121828688	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:121828688C>A	uc003idn.2	-	2	368	c.118G>T	c.(118-120)GGA>TGA	p.G40*	PRDM5_uc003ido.2_Nonsense_Mutation_p.G40*|PRDM5_uc010ine.2_Nonsense_Mutation_p.G40*|PRDM5_uc010inf.2_Nonsense_Mutation_p.G40*|PRDM5_uc003idp.1_Nonsense_Mutation_p.G40*	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	40	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						CTCTTCTCTCCAGCAAAGGGT	0.328		NA											45	114					3.51e-19	5.2e-19	1	0
DCHS2	54798	broad.mit.edu	37	4	155226280	155226280	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:155226280G>T	uc003inw.2	-	16	3999	c.3999C>A	c.(3997-3999)GAC>GAA	p.D1333E		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1333	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAATTTCTCTGTCAAGTATGG	0.338		NA											8	50					2.18e-05	2.57e-05	1	0
TLL1	7092	broad.mit.edu	37	4	166910618	166910618	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:166910618C>A	uc003irh.1	+	2	902	c.255C>A	c.(253-255)CCC>CCA	p.P85P	TLL1_uc011cjn.1_Silent_p.P85P|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	85					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CGCAGAACCCCTTTGGAAACC	0.328		NA											46	131					1.07e-20	1.61e-20	1	0
GALNTL6	442117	broad.mit.edu	37	4	173269706	173269706	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:173269706C>A	uc003isv.2	+	5	1155	c.419C>A	c.(418-420)CCA>CAA	p.P140Q		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	140	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GAAAGGCTGCCAAACACCAGC	0.403		NA											40	105					9.15e-12	1.26e-11	1	0
LRP2BP	55805	broad.mit.edu	37	4	186295607	186295607	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr4:186295607C>T	uc003ixj.1	-	4	1151	c.339G>A	c.(337-339)GGG>GGA	p.G113G	LRP2BP_uc003ixk.1_Silent_p.G87G|LRP2BP_uc011ckr.1_Silent_p.G113G	NM_018409	NP_060879	Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	113	Sel1-like 1.					cytoplasm	protein binding				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		TATAGTCCACCCCTTTCTCCT	0.393		NA											34	77					0	0	0	0
IRX1	79192	broad.mit.edu	37	5	3600253	3600253	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:3600253C>T	uc003jde.2	+	2	1243	c.1191C>T	c.(1189-1191)CCC>CCT	p.P397P		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	397						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TTGGCGCTCCCCACGCCGCGC	0.667		NA											11	42					0	0	0	0
ADCY2	108	broad.mit.edu	37	5	7709444	7709444	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:7709444G>T	uc003jdz.1	+	10	1589	c.1522G>T	c.(1522-1524)GCA>TCA	p.A508S	ADCY2_uc011cmo.1_Missense_Mutation_p.A328S	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	508	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CAAGCCCTTTGCACACCTACA	0.602		NA											8	40					5.18e-06	6.28e-06	1	0
ADCY2	108	broad.mit.edu	37	5	7826861	7826861	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:7826861G>T	uc003jdz.1	+	25	3220	c.3153G>T	c.(3151-3153)CAG>CAT	p.Q1051H	ADCY2_uc011cmo.1_Missense_Mutation_p.Q871H|ADCY2_uc010itm.1_Missense_Mutation_p.Q247H	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	1051	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TCGTCCTGCAGACCCTCGGAT	0.433		NA											23	105					4.54e-19	6.72e-19	1	0
DNAH5	1767	broad.mit.edu	37	5	13692194	13692194	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:13692194G>T	uc003jfd.2	-	79	13816	c.13774C>A	c.(13774-13776)CGA>AGA	p.R4592R	DNAH5_uc003jfc.2_Silent_p.R760R	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4592					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGTCCGTTCGAACTGGCTTC	0.468		NA							Kartagener_syndrome				15	89					6.32e-08	8.1e-08	1	0
DNAH5	1767	broad.mit.edu	37	5	13876810	13876810	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:13876810T>A	uc003jfd.2	-	22	3421	c.3379A>T	c.(3379-3381)ATC>TTC	p.I1127F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1127	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTGGAGTTGATAATTGTGCTA	0.378		NA							Kartagener_syndrome				17	82					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23524604	23524604	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:23524604G>T	uc003jgo.2	+	10	1294	c.1112G>T	c.(1111-1113)AGC>ATC	p.S371I		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	371					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AAGTGGGGCAGCAAGTGGAAG	0.468		NA								HNSCC(3;0.000094)			26	87					1.79e-09	2.38e-09	1	0
PDZD2	23037	broad.mit.edu	37	5	32090710	32090710	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:32090710G>A	uc003jhl.2	+	20	7544	c.7156G>A	c.(7156-7158)GGT>AGT	p.G2386S	PDZD2_uc003jhm.2_Missense_Mutation_p.G2386S	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2386					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGGCCACCCAGGTGACGCAGC	0.617		NA											14	52					0	0	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33534996	33534996	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:33534996G>C	uc003jia.1	-	23	4711	c.4548C>G	c.(4546-4548)CAC>CAG	p.H1516Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.H1431Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1516	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GTCTGGGTTTGTGATCACATA	0.493		NA								HNSCC(64;0.19)			35	112					0	0	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33577237	33577237	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:33577237C>G	uc003jia.1	-	19	3057	c.2894G>C	c.(2893-2895)CGG>CCG	p.R965P	ADAMTS12_uc010iuq.1_Missense_Mutation_p.R880P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	965	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ACTGCGAATCCGCACTCCACC	0.493		NA								HNSCC(64;0.19)			30	118					0	0	0	0
IL7R	3575	broad.mit.edu	37	5	35876247	35876247	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:35876247C>T	uc003jjs.2	+	8	1128	c.1039C>T	c.(1039-1041)CCC>TCC	p.P347S	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	347	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TGTGCAGAGCCCCAACTGCCC	0.502		NA											17	52					0	0	0	0
C9	735	broad.mit.edu	37	5	39308356	39308356	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:39308356C>T	uc003jlv.3	-	8	1305	c.1216G>A	c.(1216-1218)GTA>ATA	p.V406I		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	406	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CCCCTCTTTACACAATCATCT	0.418		NA											24	94					0	0	0	0
C7	730	broad.mit.edu	37	5	40979897	40979897	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:40979897C>T	uc003jmh.2	+	17	2350	c.2236C>T	c.(2236-2238)CAT>TAT	p.H746Y	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	746	Complement control factor I module 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				TTGCAAGATGCATGTTCTCCA	0.453		NA											14	53					0	0	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41000408	41000408	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:41000408G>A	uc003jmj.3	-	39	4886	c.4396C>T	c.(4396-4398)CAG>TAG	p.Q1466*	HEATR7B2_uc003jmi.3_Nonsense_Mutation_p.Q1021*	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1466							binding			ovary(6)|central_nervous_system(2)	8						TAGAGCTCCTGGAGGCCCAAA	0.488		NA											13	56					0	0	0	0
GFM2	84340	broad.mit.edu	37	5	74017519	74017519	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:74017519A>G	uc003kdh.1	-	21	2605	c.2301T>C	c.(2299-2301)GAT>GAC	p.D767D	GFM2_uc003kdi.1_Silent_p.D720D|GFM2_uc010izj.1_Silent_p.D799D|GFM2_uc010izk.1_RNA	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	767					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		GTGTATTTTGATCTTGAGGAT	0.383		NA											25	72					0	0	0	0
IQGAP2	10788	broad.mit.edu	37	5	75906917	75906917	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:75906917T>C	uc003kek.2	+	13	1652	c.1430T>C	c.(1429-1431)CTC>CCC	p.L477P	IQGAP2_uc010izv.2_Missense_Mutation_p.L30P|IQGAP2_uc011csv.1_Missense_Mutation_p.L30P|IQGAP2_uc003kel.2_Missense_Mutation_p.L30P	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	477					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GAAACTTTGCTCCTACCTACT	0.408		NA											41	86					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89933675	89933675	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:89933675T>C	uc003kju.2	+	11	2246	c.2150T>C	c.(2149-2151)TTA>TCA	p.L717S	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	717	Calx-beta 5.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTTTTGTTTTTATCTGGGCAA	0.423		NA											29	52					0	0	0	0
PAM	5066	broad.mit.edu	37	5	102286460	102286460	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:102286460G>T	uc003knw.2	+	11	1214	c.841G>T	c.(841-843)GGT>TGT	p.G281C	PAM_uc003kns.2_Missense_Mutation_p.G281C|PAM_uc003knt.2_Missense_Mutation_p.G281C|PAM_uc003knu.2_Missense_Mutation_p.G281C|PAM_uc003knv.2_Missense_Mutation_p.G281C|PAM_uc011cuz.1_Missense_Mutation_p.G184C	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	281	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TGTAAGTTTTGGTGACCTACT	0.368		NA											28	56					3.67e-24	5.61e-24	1	0
PPIP5K2	23262	broad.mit.edu	37	5	102474116	102474116	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:102474116G>A	uc003kod.3	+	5	949	c.430G>A	c.(430-432)GAA>AAA	p.E144K	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.E144K|PPIP5K2_uc010jbo.1_Missense_Mutation_p.E66K	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	144					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TCTTCAAGCTGAAGGTATTTT	0.338		NA											16	47					0	0	0	0
MCC	4163	broad.mit.edu	37	5	112384928	112384928	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:112384928C>A	uc003kqj.3	-	14	2477	c.1947G>T	c.(1945-1947)AAG>AAT	p.K649N	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.K839N|MCC_uc011cwb.1_Missense_Mutation_p.K649N	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	649					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GCGTGCTCAGCTTCAGCTCCA	0.597		NA											14	29					4.93e-13	6.92e-13	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176058	140176058	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140176058G>T	uc003lhd.2	+	1	1615	c.1509G>T	c.(1507-1509)GCG>GCT	p.A503A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.A503A|PCDHA2_uc011czy.1_Silent_p.A503A	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCGCGCGTTGTCGAGCT	0.677		NA											17	33					5.35e-07	6.66e-07	1	0
PCDHA3	56145	broad.mit.edu	37	5	140181115	140181115	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140181115C>A	uc003lhf.2	+	1	333	c.333C>A	c.(331-333)GAC>GAA	p.D111E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.D111E	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	111	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATCGTGGACAGGCCGCTGC	0.507		NA											55	115					1.11e-26	1.71e-26	1	0
PCDHA7	56141	broad.mit.edu	37	5	140215406	140215406	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140215406G>T	uc003lhq.2	+	1	1438	c.1438G>T	c.(1438-1440)GGG>TGG	p.G480W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.G480W	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	480	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGTCGGCGGGGGACGCGGA	0.672		NA											22	26					7.93e-12	1.1e-11	1	0
PCDHA9	9752	broad.mit.edu	37	5	140229949	140229949	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140229949C>T	uc003lhu.2	+	1	2593	c.1869C>T	c.(1867-1869)CGC>CGT	p.R623R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.R623R	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	623	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCGTTCCGCGTGGGGCTGT	0.667		NA											18	50					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236300	140236300	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140236300G>T	uc003lhx.2	+	1	667	c.667G>T	c.(667-669)GGA>TGA	p.G223*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Nonsense_Mutation_p.G223*|PCDHA10_uc011dad.1_Nonsense_Mutation_p.G223*	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	223	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAATTTACCGGATCTGTTTC	0.433		NA											60	113					6.2e-27	9.56e-27	1	0
PCDHA11	56138	broad.mit.edu	37	5	140250827	140250827	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140250827G>T	uc003lia.2	+	1	2997	c.2139G>T	c.(2137-2139)ACG>ACT	p.T713T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.T713T	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	713	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTACTCACGCTGCTGCTGT	0.687		NA											12	30					1.09e-07	1.38e-07	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553967	140553967	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140553967G>T	uc003lit.2	+	1	1725	c.1551G>T	c.(1549-1551)AGG>AGT	p.R517S		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	517	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTGCCCTCAGGTCCCTGGACT	0.706		NA											28	60					2.44e-19	3.62e-19	1	0
PCDHB10	56126	broad.mit.edu	37	5	140573129	140573129	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:140573129T>A	uc003lix.2	+	1	1178	c.1004T>A	c.(1003-1005)GTG>GAG	p.V335E		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	335	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGGTTTTAGTGGAAGTATTG	0.408		NA											41	80					0	0	0	0
SLC36A2	153201	broad.mit.edu	37	5	150712872	150712872	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:150712872G>A	uc003lty.2	-	7	886	c.756C>T	c.(754-756)GAC>GAT	p.D252D	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Silent_p.D54D|SLC36A2_uc010jhv.2_Silent_p.D252D	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	252	Extracellular (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCGGCTGGGGTCTGGGATTT	0.438		NA											25	56					0	0	0	0
FOXI1	2299	broad.mit.edu	37	5	169535593	169535593	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:169535593C>A	uc003mai.3	+	2	1160	c.1115C>A	c.(1114-1116)CCC>CAC	p.P372H	FOXI1_uc003maj.3_Missense_Mutation_p.P277H	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	372					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCTCTACCCCAGGGAGGGC	0.572		NA							Pendred_syndrome				24	75					7.38e-10	9.91e-10	1	0
RANBP17	64901	broad.mit.edu	37	5	170720913	170720913	+	Silent	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:170720913T>A	uc003mba.2	+	26	2986	c.2970T>A	c.(2968-2970)ATT>ATA	p.I990I	RANBP17_uc003mbb.2_Silent_p.I315I|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	990					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGAACACCATTGTCTTTGAAG	0.488		NA	T	TRD@	ALL								61	137					0	0	0	0
HK3	3101	broad.mit.edu	37	5	176309035	176309035	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:176309035C>T	uc003mfa.2	-	16	2239	c.2147G>A	c.(2146-2148)GGC>GAC	p.G716D	HK3_uc003mez.2_Missense_Mutation_p.G272D	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	716	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCAAAGGCGCCCCACTCCAT	0.632		NA											23	56					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176637631	176637631	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:176637631C>G	uc003mfr.3	+	5	2369	c.2231C>G	c.(2230-2232)TCA>TGA	p.S744*	NSD1_uc003mft.3_Nonsense_Mutation_p.S475*|NSD1_uc003mfs.1_Nonsense_Mutation_p.S641*|NSD1_uc011dfx.1_Nonsense_Mutation_p.S392*	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	744					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AAACCCCAGTCAGATTTTACA	0.438		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			25	56					0	0	0	0
CAP2	10486	broad.mit.edu	37	6	17539517	17539517	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:17539517A>G	uc003ncb.2	+	8	897	c.654A>G	c.(652-654)ACA>ACG	p.T218T	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Silent_p.T192T|CAP2_uc011djb.1_Silent_p.T154T|CAP2_uc011djc.1_Silent_p.T106T|CAP2_uc011djd.1_Intron	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	218					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			TAGCATCCACAGTATCAGCGT	0.567		NA											59	195					0	0	0	0
SOX4	6659	broad.mit.edu	37	6	21596066	21596066	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:21596066T>G	uc003ndi.2	+	1	2095	c.1301T>G	c.(1300-1302)TTT>TGT	p.F434C		NM_003107	NP_003098	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	434					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity				0	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			GACCTGGATTTTAACTTCGAG	0.607		NA											10	26					0	0	0	0
FAM65B	9750	broad.mit.edu	37	6	24873954	24873954	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:24873954C>A	uc003neo.1	-	3	351	c.175G>T	c.(175-177)GGC>TGC	p.G59C	FAM65B_uc011djs.1_Missense_Mutation_p.G88C|FAM65B_uc011dju.1_Missense_Mutation_p.G93C|FAM65B_uc003nep.2_Missense_Mutation_p.G59C|FAM65B_uc011djt.1_Missense_Mutation_p.G59C	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	59	Involved in cell filopodia formation.				cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						TTTTTGTGGCCTAAATTGTGC	0.428		NA											26	107					4.27e-12	5.91e-12	1	0
SCGN	10590	broad.mit.edu	37	6	25665232	25665232	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:25665232C>A	uc003nfb.2	+	4	511	c.308C>A	c.(307-309)CCA>CAA	p.P103Q	SCGN_uc010jpz.2_Missense_Mutation_p.H13N	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	103						extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						CGGGAAAACCCACTGGACAGC	0.493		NA											17	70					4.97e-08	6.38e-08	1	0
HIST1H2AH	85235	broad.mit.edu	37	6	27115070	27115070	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:27115070G>A	uc003niz.2	+	1	163	c.163G>A	c.(163-165)GTG>ATG	p.V55M	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	55					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCTGGCTGCGGTGCTGGAGTA	0.652		NA											26	59					0	0	0	0
OR2W1	26692	broad.mit.edu	37	6	29012793	29012793	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:29012793G>T	uc003nlw.2	-	1	160	c.160C>A	c.(160-162)CAG>AAG	p.Q54K		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GTATGAAGCTGGGAATCCAGG	0.428		NA											38	106					1.84e-18	2.7e-18	1	0
PPP1R11	6992	broad.mit.edu	37	6	30035206	30035206	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:30035206G>A	uc003npb.2	+	1	275	c.19G>A	c.(19-21)GGG>AGG	p.G7R	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	7						soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3						GGCAGGGGCTGGGCTGAGCGA	0.612		NA											27	100					0	0	0	0
TRIM39	56658	broad.mit.edu	37	6	30309588	30309588	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:30309588C>T	uc010jrz.2	+	9	1421	c.1109C>T	c.(1108-1110)CCT>CTT	p.P370L	TRIM39_uc003npz.2_Missense_Mutation_p.P340L|TRIM39_uc003nqb.2_Missense_Mutation_p.P340L|TRIM39_uc003nqc.2_Missense_Mutation_p.P340L|TRIM39_uc010jsa.1_Missense_Mutation_p.P340L	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	370	B30.2/SPRY.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						CGGGATCTCCCTGACACACCA	0.572		NA											15	40					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38754683	38754683	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:38754683G>A	uc003ooe.1	+	16	2487	c.1887G>A	c.(1885-1887)TTG>TTA	p.L629L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAAAGAGATTGCTAAAATTGG	0.308		NA											13	52					0	0	0	0
KIF6	221458	broad.mit.edu	37	6	39353414	39353414	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:39353414T>C	uc003oot.2	-	16	1940	c.1845A>G	c.(1843-1845)ATA>ATG	p.I615M	KIF6_uc003oos.2_Missense_Mutation_p.I66M|KIF6_uc010jwz.1_Translation_Start_Site|KIF6_uc010jxa.1_Missense_Mutation_p.I406M|KIF6_uc011dua.1_Intron|KIF6_uc010jxb.1_Missense_Mutation_p.I559M	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	615	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						CTACTTGCTGTATATGCCGCT	0.448		NA											15	74					0	0	0	0
UBR2	23304	broad.mit.edu	37	6	42613293	42613293	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:42613293G>A	uc011dur.1	+	21	2374	c.2374G>A	c.(2374-2376)GCT>ACT	p.A792T	UBR2_uc011dus.1_Missense_Mutation_p.A437T|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	792					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CAAGCCTATGGCTCATAGTGA	0.373		NA											28	82					0	0	0	0
C6orf138	442213	broad.mit.edu	37	6	47846286	47846286	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:47846286G>T	uc011dwm.1	-	3	2328	c.2243C>A	c.(2242-2244)TCT>TAT	p.S748Y	C6orf138_uc011dwn.1_Missense_Mutation_p.S512Y	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	765	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						AATAAGAAAAGAAGTAACATT	0.443		NA											12	36					0.000978159	0.00108025	1	0
PGK2	5232	broad.mit.edu	37	6	49754394	49754394	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:49754394T>C	uc003ozu.2	-	1	614	c.507A>G	c.(505-507)GCA>GCG	p.A169A		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	169					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GAGCGCGGTGTGCAGTGCCAA	0.453		NA											28	73					0	0	0	0
PKHD1	5314	broad.mit.edu	37	6	51927386	51927386	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:51927386T>A	uc003pah.1	-	14	1325	c.1049A>T	c.(1048-1050)TAC>TTC	p.Y350F	PKHD1_uc003pai.2_Missense_Mutation_p.Y350F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	350	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTGCCACCTGTACCCTGGGGT	0.483		NA											49	118					0	0	0	0
ZNF451	26036	broad.mit.edu	37	6	57012801	57012801	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:57012801C>T	uc003pdm.1	+	10	2142	c.1918C>T	c.(1918-1920)CAC>TAC	p.H640Y	ZNF451_uc003pdl.2_Missense_Mutation_p.H640Y|ZNF451_uc003pdn.1_Missense_Mutation_p.H640Y|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.H640Y	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	640	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CAGCTGTGCTCACTGCAGAAA	0.398		NA											31	105					0	0	0	0
BAI3	577	broad.mit.edu	37	6	69653751	69653751	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:69653751T>C	uc003pev.3	+	6	1508	c.1060T>C	c.(1060-1062)TGG>CGG	p.W354R	BAI3_uc010kak.2_Missense_Mutation_p.W354R	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	354	Extracellular (Potential).|TSP type-1 2.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATGGTCACCATGGAGTTTATG	0.413		NA											51	148					0	0	0	0
BAI3	577	broad.mit.edu	37	6	69703837	69703837	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:69703837G>T	uc003pev.3	+	11	2360	c.1912G>T	c.(1912-1914)GCA>TCA	p.A638S	BAI3_uc010kak.2_Missense_Mutation_p.A638S	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	638	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TTACATCCCTGCATCTGATGG	0.453		NA											24	68					4.4e-07	5.48e-07	1	0
MYO6	4646	broad.mit.edu	37	6	76624544	76624544	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:76624544G>T	uc003pih.1	+	35	3952	c.3673G>T	c.(3673-3675)GAG>TAG	p.E1225*	MYO6_uc003pii.1_Nonsense_Mutation_p.E1202*|MYO6_uc003pij.1_Nonsense_Mutation_p.E173*	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1234					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GGACGACATGGAGATGTGTGA	0.448		NA											11	60					2.81e-09	3.7e-09	1	0
IMPG1	3617	broad.mit.edu	37	6	76715168	76715168	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:76715168G>T	uc003pik.1	-	10	1101	c.971C>A	c.(970-972)TCT>TAT	p.S324Y		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	324	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GGAATCAAAAGACAGGAGGTC	0.453		NA											26	108					1.18e-14	1.68e-14	1	0
HTR1E	3354	broad.mit.edu	37	6	87725859	87725859	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:87725859C>A	uc003pli.2	+	2	1510	c.807C>A	c.(805-807)GAC>GAA	p.D269E		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	269	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CCCCCTTCGACAATGATCTAG	0.502		NA											67	218					4.67e-28	7.24e-28	1	0
GABRR1	2569	broad.mit.edu	37	6	89888653	89888653	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:89888653G>T	uc003pna.2	-	10	1731	c.1276C>A	c.(1276-1278)CAG>AAG	p.Q426K	GABRR1_uc011dzv.1_Missense_Mutation_p.Q403K	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	426	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AGGGTCAGCTGCACCATCATC	0.542		NA											29	155					8.17e-17	1.19e-16	1	0
MDN1	23195	broad.mit.edu	37	6	90383950	90383950	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:90383950G>A	uc003pnn.1	-	79	13236	c.13120C>T	c.(13120-13122)CGG>TGG	p.R4374W		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4374					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCTGTTTCCGCATCCGGCAA	0.463		NA											21	72					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90402372	90402372	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:90402372C>A	uc003pnn.1	-	63	10493	c.10377G>T	c.(10375-10377)TTG>TTT	p.L3459F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3459					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCACCGAGCACAAAGTGTCTG	0.587		NA											39	156					1.05e-18	1.54e-18	1	0
MDN1	23195	broad.mit.edu	37	6	90402456	90402456	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:90402456C>T	uc003pnn.1	-	63	10409	c.10293G>A	c.(10291-10293)AGG>AGA	p.R3431R		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3431					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGGTCCCCAGCCTGTCTGCAC	0.582		NA											29	71					0	0	0	0
RFX6	222546	broad.mit.edu	37	6	117215197	117215197	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:117215197A>T	uc003pxm.2	+	5	677	c.614A>T	c.(613-615)CAC>CTC	p.H205L		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	205					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GCATATTACCACTCCGTTTAT	0.393		NA											38	140					0	0	0	0
RSPO3	84870	broad.mit.edu	37	6	127471641	127471641	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:127471641A>G	uc003qar.2	+	3	650	c.360A>G	c.(358-360)TTA>TTG	p.L120L	RSPO3_uc003qas.1_Silent_p.L120L	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	120	FU 2.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		GATTTTACTTACACCTTGGAA	0.368		NA											17	112					0	0	0	0
C6orf174	387104	broad.mit.edu	37	6	127796902	127796902	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:127796902C>T	uc003qbd.2	-	6	3134	c.2269G>A	c.(2269-2271)GCG>ACG	p.A757T	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	757						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TTCTTGCCCGCGTCGCTCTCG	0.697		NA											28	90					0	0	0	0
THEMIS	387357	broad.mit.edu	37	6	128134032	128134032	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:128134032G>A	uc003qbi.2	-	5	2073	c.1754C>T	c.(1753-1755)CCC>CTC	p.P585L	THEMIS_uc010kfa.2_Missense_Mutation_p.P488L|THEMIS_uc011ebt.1_Missense_Mutation_p.P585L|THEMIS_uc010kfb.2_Missense_Mutation_p.P550L	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	585					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CCTTACCTTGGGAGACTTGGG	0.463		NA											82	276					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129371138	129371138	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:129371138C>A	uc003qbn.2	+	2	293	c.188C>A	c.(187-189)CCT>CAT	p.P63H	LAMA2_uc003qbo.2_Missense_Mutation_p.P63H	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	63	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAAAAAGGACCTGAAATGTAC	0.448		NA											28	82					1.13e-08	1.47e-08	1	0
L3MBTL3	84456	broad.mit.edu	37	6	130381238	130381238	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:130381238G>T	uc003qbt.2	+	10	987	c.817G>T	c.(817-819)GTG>TTG	p.V273L	L3MBTL3_uc003qbu.2_Missense_Mutation_p.V248L	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	273	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		ATTAGAAGGCGTGGATCCTGA	0.398		NA											18	64					5.35e-11	7.32e-11	1	0
L3MBTL3	84456	broad.mit.edu	37	6	130392248	130392248	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:130392248A>G	uc003qbt.2	+	13	1390	c.1220A>G	c.(1219-1221)AAC>AGC	p.N407S	L3MBTL3_uc003qbu.2_Missense_Mutation_p.N382S	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	407	MBT 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CATTTTGACAACTGGGATGAG	0.313		NA											64	223					0	0	0	0
SAMD3	154075	broad.mit.edu	37	6	130535556	130535556	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:130535556C>G	uc003qbv.2	-	5	521	c.195G>C	c.(193-195)CAG>CAC	p.Q65H	SAMD3_uc003qbx.2_Missense_Mutation_p.Q65H|SAMD3_uc003qbw.2_Missense_Mutation_p.Q65H|SAMD3_uc010kfg.1_Missense_Mutation_p.Q65H|SAMD3_uc003qby.2_Missense_Mutation_p.Q65H|SAMD3_uc003qbz.1_Missense_Mutation_p.Q24H	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	65	SAM.									ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CTTGAGTGTTCTGCTTGTATT	0.448		NA											65	202					0	0	0	0
CTGF	1490	broad.mit.edu	37	6	132271472	132271472	+	Silent	SNP	G	G	A	rs139453995		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:132271472G>A	uc003qcz.2	-	3	707	c.501C>T	c.(499-501)GAC>GAT	p.D167D		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	167	VWFC.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		CCTTGGGCTCGTCACACACCC	0.632		NA									OREG0017666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	160					0	0	0	0
TAAR1	134864	broad.mit.edu	37	6	132966320	132966320	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:132966320G>T	uc003qdm.1	-	1	823	c.823C>A	c.(823-825)CCT>ACT	p.P275T		NM_138327	NP_612200	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	275	Extracellular (Potential).					plasma membrane					0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	TGAAGAAAAGGGTCCATGACT	0.368		NA											21	95					1.5e-11	2.07e-11	1	0
STXBP5	134957	broad.mit.edu	37	6	147655334	147655334	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:147655334G>A	uc003qlz.2	+	19	2283	c.2122G>A	c.(2122-2124)GAT>AAT	p.D708N	STXBP5_uc010khz.1_Missense_Mutation_p.D708N|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.D379N|STXBP5_uc003qma.2_Missense_Mutation_p.D55N	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	708					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TGTTCCAGAGGATCGCTGCAA	0.328		NA											26	76					0	0	0	0
RAET1G	353091	broad.mit.edu	37	6	150240901	150240901	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:150240901C>T	uc010kii.1	-	2	205	c.137G>A	c.(136-138)GGA>GAA	p.G46E	RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	46	MHC class I alpha-1 like.|Extracellular (Potential).				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CCACCGTGGTCCAGGTCTGAA	0.552		NA											7	202					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152708424	152708424	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:152708424T>A	uc010kiw.2	-	54	8872	c.8270A>T	c.(8269-8271)GAA>GTA	p.E2757V	SYNE1_uc003qot.3_Missense_Mutation_p.E2764V|SYNE1_uc003qou.3_Missense_Mutation_p.E2757V|SYNE1_uc010kjb.1_Missense_Mutation_p.E2740V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2757	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAAGGGATGTTCTATTTTTTG	0.458		NA								HNSCC(10;0.0054)			41	145					0	0	0	0
TIAM2	26230	broad.mit.edu	37	6	155450864	155450864	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:155450864G>T	uc003qqb.2	+	6	1780	c.507G>T	c.(505-507)CTG>CTT	p.L169L	TIAM2_uc003qqe.2_Silent_p.L169L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	169					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGGGGAAGCTGGATGGGTGTT	0.587		NA											17	68					2.39e-15	3.43e-15	1	0
FNDC1	84624	broad.mit.edu	37	6	159660563	159660563	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:159660563C>A	uc010kjv.2	+	14	4395	c.4195C>A	c.(4195-4197)CCC>ACC	p.P1399T	FNDC1_uc010kjw.1_Missense_Mutation_p.P1284T	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1399						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GGAAGGGACCCCCGTGGTGAG	0.483		NA											3	11					0.004672	0.00498285	1	0
SMOC2	64094	broad.mit.edu	37	6	169064781	169064781	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:169064781C>T	uc003qws.1	+	12	1333	c.1313C>T	c.(1312-1314)TCT>TTT	p.S438F	SMOC2_uc003qwr.1_Missense_Mutation_p.S449F|SMOC2_uc011egu.1_Missense_Mutation_p.S115F	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	438					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		GAAAGTACGTCTAATAGACAG	0.294		NA											18	55					0	0	0	0
RSPH10B2	728194	broad.mit.edu	37	7	6838029	6838029	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:6838029A>G	uc003sqw.1	+	21	2739	c.2468A>G	c.(2467-2469)AAG>AGG	p.K823R	RSPH10B2_uc010ktk.1_Missense_Mutation_p.K823R|RSPH10B2_uc010ktl.1_RNA	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	823										ovary(1)|pancreas(1)|skin(1)	3						GAAGAGGCCAAGAGACATGAC	0.483		NA											18	125					0	0	0	0
THSD7A	221981	broad.mit.edu	37	7	11416278	11416278	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:11416278C>G	uc003ssf.3	-	26	5060	c.4808G>C	c.(4807-4809)AGA>ACA	p.R1603T	uc003ssb.2_Intron|THSD7A_uc003ssd.3_Missense_Mutation_p.R107T	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1603	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GGTCTTTAGTCTCCCATCTAA	0.353		NA								HNSCC(18;0.044)			4	8					0	0	0	0
TMEM195	392636	broad.mit.edu	37	7	15430298	15430298	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:15430298G>C	uc003stb.1	-	8	990	c.820C>G	c.(820-822)CAG>GAG	p.Q274E		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	274					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TATGTTACCTGCACTTTGATT	0.269		NA											30	136					0	0	0	0
TMEM195	392636	broad.mit.edu	37	7	15430330	15430330	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:15430330T>C	uc003stb.1	-	8	958	c.788A>G	c.(787-789)CAT>CGT	p.H263R		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	263					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						ATTAATGGGATGTGTTAAGCC	0.294		NA											35	153					0	0	0	0
ABCB5	340273	broad.mit.edu	37	7	20762764	20762764	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:20762764C>T	uc003suw.3	+	12	1758	c.1212C>T	c.(1210-1212)GCC>GCT	p.A404A	ABCB5_uc010kuh.2_Silent_p.A849A|ABCB5_uc003sux.1_Silent_p.A27A	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	404	Cytoplasmic (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CAGTACTTGCCGTGACAGGAA	0.388		NA											33	94					0	0	0	0
CHN2	1124	broad.mit.edu	37	7	29539573	29539573	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:29539573G>T	uc003szz.2	+	9	1267	c.830G>T	c.(829-831)TGT>TTT	p.C277F	CHN2_uc011jzs.1_Missense_Mutation_p.C352F|CHN2_uc010kva.2_Missense_Mutation_p.C47F|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.C242F|CHN2_uc011jzt.1_Missense_Mutation_p.C290F|CHN2_uc010kvd.2_Missense_Mutation_p.C133F|CHN2_uc011jzu.1_Missense_Mutation_p.C262F|CHN2_uc010kvg.2_Missense_Mutation_p.C141F|CHN2_uc010kvh.2_Intron|CHN2_uc010kvi.2_Missense_Mutation_p.C141F|CHN2_uc010kve.2_Missense_Mutation_p.C141F|CHN2_uc003taa.2_Missense_Mutation_p.C141F|CHN2_uc010kvf.2_Intron|CHN2_uc010kvj.2_Missense_Mutation_p.C96F|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.C96F|CHN2_uc011jzv.1_Missense_Mutation_p.C70F	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	277	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						GTGTACTGTTGTGACCTCACA	0.443		NA											13	46					2.27e-07	2.87e-07	1	0
NEUROD6	63974	broad.mit.edu	37	7	31378419	31378419	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:31378419C>T	uc003tch.2	-	2	817	c.464G>A	c.(463-465)AGA>AAA	p.R155K		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	155					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						CAGATCTGGTCTCTTGCCGAT	0.458		NA											19	88					0	0	0	0
PSMA2	5683	broad.mit.edu	37	7	42966149	42966149	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:42966149C>A	uc003thy.2	-	3	285	c.237G>T	c.(235-237)ATG>ATT	p.M79I	C7orf25_uc010kxr.2_Intron|PSMA2_uc010kxt.2_Missense_Mutation_p.M1I|PSMA2_uc003thz.1_Missense_Mutation_p.M1I	NM_002787	NP_002778	P25787	PSA2_HUMAN	proteasome subunit alpha type 2	79					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			large_intestine(2)|ovary(1)	3						AATCGGGGCCCATGCCACTGT	0.368		NA											26	71					2.49e-11	3.42e-11	1	0
MYO1G	64005	broad.mit.edu	37	7	45004594	45004594	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:45004594G>A	uc003tmh.2	-	18	2620	c.2476C>T	c.(2476-2478)CGT>TGT	p.R826C	MYO1G_uc003tmf.2_Missense_Mutation_p.R269C|MYO1G_uc003tmg.2_Missense_Mutation_p.R588C|MYO1G_uc010kym.2_Missense_Mutation_p.R711C	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	826				R->A: Reduced membrane association.		myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						CAGTCCTGACGAAGCCCTTGC	0.677		NA											31	98					0	0	0	0
UPP1	7378	broad.mit.edu	37	7	48141563	48141563	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:48141563C>T	uc003toj.2	+	6	834	c.305C>T	c.(304-306)CCG>CTG	p.P102L	UPP1_uc003tok.2_Missense_Mutation_p.P102L|UPP1_uc003tol.2_Missense_Mutation_p.P102L|UPP1_uc011kcg.1_Missense_Mutation_p.P102L|UPP1_uc011kch.1_Intron|UPP1_uc003ton.2_Intron|UPP1_uc003too.2_Intron	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	102					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						AAAGTAGGACCGGTGCTGTCT	0.572		NA											28	64					0	0	0	0
WBSCR17	64409	broad.mit.edu	37	7	70881051	70881051	+	Splice_Site	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:70881051T>C	uc003tvy.2	+	4	764	c.764_splice	c.e4+2	p.W255_splice	WBSCR17_uc003tvz.2_Splice_Site	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CGCTGGCTGGTAGGTCATGAG	0.582		NA											8	78					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82579581	82579581	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:82579581C>A	uc003uhx.2	-	6	10612	c.10323G>T	c.(10321-10323)GTG>GTT	p.V3441V	PCLO_uc003uhv.2_Silent_p.V3441V|PCLO_uc010lec.2_Silent_p.V406V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3372					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACCACTGTCCACTATCTTTT	0.433		NA											65	81					9.41e-28	1.45e-27	1	0
ZNF804B	219578	broad.mit.edu	37	7	88963725	88963725	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:88963725C>A	uc011khi.1	+	4	1967	c.1429C>A	c.(1429-1431)CCA>ACA	p.P477T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	477						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGGCTGCAACCCACTGTATTT	0.428		NA								HNSCC(36;0.09)			56	43					4.33e-22	6.54e-22	1	0
AKAP9	10142	broad.mit.edu	37	7	91730192	91730192	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:91730192G>C	uc003ulg.2	+	45	11144	c.10919G>C	c.(10918-10920)GGT>GCT	p.G3640A	AKAP9_uc003ulf.2_Missense_Mutation_p.G3632A|AKAP9_uc003uli.2_Missense_Mutation_p.G3263A|AKAP9_uc003ulj.2_Missense_Mutation_p.G1410A|AKAP9_uc003ull.2_Missense_Mutation_p.G536A	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3644	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCATTGAATGGTGGTGCCAAC	0.393		NA	T	BRAF	papillary thyroid								109	128					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94049949	94049949	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:94049949G>T	uc003ung.1	+	37	2755	c.2284G>T	c.(2284-2286)GCT>TCT	p.A762S	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	762			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CGTTGGAGCTGCTGGCCCAGC	0.512		NA								HNSCC(75;0.22)			4	8					0.00909568	0.00953133	1	0
PON1	5444	broad.mit.edu	37	7	94931576	94931576	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:94931576A>T	uc003uns.2	-	8	947	c.850T>A	c.(850-852)TGC>AGC	p.C284S	PON1_uc011kih.1_Missense_Mutation_p.C284S	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	284				C->A,S: No loss of activity.	aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TTGGGATGGCATCCAACCCAA	0.388		NA											58	59					0	0	0	0
DLX5	1749	broad.mit.edu	37	7	96650323	96650324	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:96650323_96650324CG>AA	uc003uon.2	-	3	802_803	c.594_595CG>TT	c.(592-597)AACGGG>AATTGG	p.G199W		NM_005221	NP_005212	P56178	DLX5_HUMAN	distal-less homeobox 5	199					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GGCATCTCCCCGTTTTTCATGA	0.574		NA											16	96					0	0	0	0
LMTK2	22853	broad.mit.edu	37	7	97822447	97822447	+	Silent	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:97822447T>C	uc003upd.1	+	11	2963	c.2670T>C	c.(2668-2670)AGT>AGC	p.S890S		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	890					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CTGGCGAGAGTGAGGAGACCC	0.557		NA											51	50					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100675651	100675651	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:100675651G>T	uc003uxp.1	+	3	1007	c.954G>T	c.(952-954)ACG>ACT	p.T318T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	318	Extracellular (Potential).|Ser-rich.|3.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCCTACAACGGCTGAAGGCA	0.502		NA											73	354					9.56e-25	1.46e-24	1	0
CUX1	1523	broad.mit.edu	37	7	101892287	101892287	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:101892287G>A	uc003uyx.3	+	24	4521	c.4483G>A	c.(4483-4485)GCC>ACC	p.A1495T	CUX1_uc003uys.3_Missense_Mutation_p.A1506T|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	1495					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GGAGAAGGCCGCCAGCCGGGA	0.726		NA											6	9					0	0	0	0
RINT1	60561	broad.mit.edu	37	7	105190713	105190713	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:105190713A>G	uc003vda.1	+	9	1344	c.1113A>G	c.(1111-1113)GAA>GAG	p.E371E	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	371	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TTTAGCTTGAATTTTCTCGGG	0.363		NA											166	188					0	0	0	0
NAMPT	10135	broad.mit.edu	37	7	105909600	105909600	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:105909600C>A	uc003vdq.2	-	5	914	c.606G>T	c.(604-606)GAG>GAT	p.E202D	NAMPT_uc003vdr.1_Missense_Mutation_p.E202D|NAMPT_uc011klu.1_Missense_Mutation_p.E115D	NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	202					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1						AGTTACTTACCTCTTGGGAAG	0.358		NA											55	67					3.94e-18	5.78e-18	1	0
HBP1	26959	broad.mit.edu	37	7	106822945	106822945	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:106822945A>G	uc003vdy.2	+	3	483	c.297A>G	c.(295-297)CCA>CCG	p.P99P	HBP1_uc011klv.1_Silent_p.P109P|HBP1_uc003vdz.2_Silent_p.P99P|HBP1_uc003vea.2_Silent_p.P99P|HBP1_uc003veb.1_Silent_p.P99P	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	99					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						CAGACATACCAGAAACTACTT	0.423		NA											49	71					0	0	0	0
WNT2	7472	broad.mit.edu	37	7	116955239	116955239	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:116955239A>T	uc003viz.2	-	3	774	c.474T>A	c.(472-474)AGT>AGA	p.S158R	WNT2_uc003vja.2_Missense_Mutation_p.S62R	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	158					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CAATGTTATCACTGCAGCCAC	0.433		NA											80	109					0	0	0	0
IQUB	154865	broad.mit.edu	37	7	123104887	123104887	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:123104887C>A	uc003vkn.2	-	10	2335	c.1758G>T	c.(1756-1758)AAG>AAT	p.K586N	IQUB_uc003vko.2_Missense_Mutation_p.K586N|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Missense_Mutation_p.K586N	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	586										ovary(3)|large_intestine(1)	4						TGTAGAATACCTTAAGGTATT	0.303		NA											29	140					2.13e-12	2.96e-12	1	0
IQUB	154865	broad.mit.edu	37	7	123152340	123152340	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:123152340C>A	uc003vkn.2	-	2	632	c.55G>T	c.(55-57)GAG>TAG	p.E19*	IQUB_uc003vko.2_Nonsense_Mutation_p.E19*|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Nonsense_Mutation_p.E19*|IQUB_uc003vkq.2_Nonsense_Mutation_p.E19*	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	19										ovary(3)|large_intestine(1)	4						TCATCACTCTCTTCTGTTGAA	0.348		NA											25	147					1.97e-08	2.56e-08	1	0
POT1	25913	broad.mit.edu	37	7	124499083	124499083	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:124499083G>A	uc003vlm.2	-	9	1231	c.630C>T	c.(628-630)ATC>ATT	p.I210I	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Silent_p.I79I|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	210					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						GTAGCCGATGGATGTGACTTA	0.393		NA											60	59					0	0	0	0
KLF14	136259	broad.mit.edu	37	7	130418350	130418350	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:130418350G>C	uc003vqk.1	-	1	511	c.511C>G	c.(511-513)CTA>GTA	p.L171V		NM_138693	NP_619638	Q8TD94	KLF14_HUMAN	Kruppel-like factor 14	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(18;0.0435)					CCTGCCCCTAGGGCCCCTCCA	0.741		NA											4	10					0	0	0	0
PLXNA4	91584	broad.mit.edu	37	7	132193309	132193309	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:132193309G>T	uc003vra.3	-	2	373	c.144C>A	c.(142-144)GCC>GCA	p.A48A	PLXNA4_uc003vrc.2_Silent_p.A48A|PLXNA4_uc003vrb.2_Silent_p.A48A	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	48	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGAAACCCTCGGCGGGCTCTC	0.587		NA											18	90					9.17e-09	1.2e-08	1	0
TRIM24	8805	broad.mit.edu	37	7	138261116	138261116	+	Splice_Site	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:138261116A>T	uc003vuc.2	+	13	2230	c.2015_splice	c.e13-2	p.G672_splice	TRIM24_uc003vub.2_Splice_Site_p.G638_splice	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha						cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						CCCCCTCCTCAGGACCTGTTA	0.423		NA											25	130					0	0	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603874	138603874	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:138603874C>A	uc011kql.1	-	2	547	c.498G>T	c.(496-498)TGG>TGT	p.W166C	KIAA1549_uc003vuk.3_Missense_Mutation_p.W116C|KIAA1549_uc011kqj.1_Missense_Mutation_p.W166C	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	166						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GTGGAGTGGTCCAGTGAGTAT	0.498		NA	O	BRAF	pilocytic astrocytoma								156	175					7.08e-60	1.13e-59	1	0
MGAM	8972	broad.mit.edu	37	7	141754672	141754672	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:141754672G>T	uc003vwy.2	+	27	3332	c.3278G>T	c.(3277-3279)GGG>GTG	p.G1093V		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1093	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AATCCATTTGGGATTGAAATT	0.493		NA											67	104					1.78e-30	2.76e-30	1	0
MGAM	8972	broad.mit.edu	37	7	141796147	141796147	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:141796147G>A	uc003vwy.2	+	42	4990	c.4936G>A	c.(4936-4938)GTG>ATG	p.V1646M		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1646	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTCAGACCAGGTGACATGGGA	0.572		NA											47	40					0	0	0	0
C7orf34	135927	broad.mit.edu	37	7	142636723	142636723	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:142636723C>T	uc003wca.2	+	1	121	c.80C>T	c.(79-81)CCT>CTT	p.P27L		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	2						extracellular region					0	Melanoma(164;0.059)					AGGTCCATGCCTCCCCTGGCC	0.662		NA											14	60					0	0	0	0
KRBA1	84626	broad.mit.edu	37	7	149420905	149420905	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:149420905A>T	uc003wfz.2	+	8	1252	c.853A>T	c.(853-855)AGG>TGG	p.R285W	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_5'UTR	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	285										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCCCAGGACAGGCATCCCAG	0.587		NA											13	80					0	0	0	0
ZNF467	168544	broad.mit.edu	37	7	149462101	149462101	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:149462101C>T	uc003wgd.2	-	5	1631	c.1490G>A	c.(1489-1491)AGC>AAC	p.S497N	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	497	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGACTTGCGGCTGAAGCGGCG	0.716		NA											8	19					0	0	0	0
NOS3	4846	broad.mit.edu	37	7	150696317	150696317	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:150696317C>A	uc003wif.2	+	9	1292	c.996C>A	c.(994-996)GCC>GCA	p.A332A	NOS3_uc011kuy.1_Silent_p.A126A|NOS3_uc011kuz.1_Silent_p.A332A|NOS3_uc011kva.1_Silent_p.A332A|NOS3_uc011kvb.1_Silent_p.A332A	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	332	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GCTGGTACGCCCTCCCGGCAG	0.647		NA											130	124					4.07e-59	6.49e-59	1	0
AGAP3	116988	broad.mit.edu	37	7	150817174	150817174	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:150817174C>G	uc003wjg.1	+	8	1073	c.1070C>G	c.(1069-1071)GCC>GGC	p.A357G	AGAP3_uc003wje.1_Missense_Mutation_p.A129G|AGAP3_uc003wjf.1_Missense_Mutation_p.A357G|AGAP3_uc010lpy.1_Intron|AGAP3_uc003wjh.1_Missense_Mutation_p.A537G|AGAP3_uc003wji.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	321	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						ACCATCGCTGCCTCCTCCACC	0.667		NA											3	64					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151879345	151879345	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:151879345C>G	uc003wla.2	-	36	5819	c.5600G>C	c.(5599-5601)AGT>ACT	p.S1867T	MLL3_uc003wkz.2_Missense_Mutation_p.S928T	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1867	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTGAGAAAGACTATCCTGGAT	0.522		NA	N		medulloblastoma								27	193					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154681206	154681206	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:154681206A>G	uc003wlk.2	+	25	2546	c.2417A>G	c.(2416-2418)CAA>CGA	p.Q806R	DPP6_uc003wli.2_Missense_Mutation_p.Q742R|DPP6_uc003wlm.2_Missense_Mutation_p.Q744R|DPP6_uc011kvq.1_Missense_Mutation_p.Q699R	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	806	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CTCATTACACAACTAATTAGG	0.378		NA											9	15					0	0	0	0
DLGAP2	9228	broad.mit.edu	37	8	1513941	1513941	+	Silent	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:1513941C>T	uc003wpl.2	+	3	1180	c.1083C>T	c.(1081-1083)GCC>GCT	p.A361A	DLGAP2_uc003wpm.2_Silent_p.A361A	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	440					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACATTAAAGCCATGGGGGACG	0.572		NA											4	19					0	0	0	0
DEFB4A	1673	broad.mit.edu	37	8	7752250	7752250	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:7752250C>A	uc003wsd.2	+	1	52	c.16C>A	c.(16-18)CTC>ATC	p.L6I		NM_004942	NP_004933	O15263	DFB4A_HUMAN	defensin, beta 4 precursor	6					chemotaxis|defense response to bacterium|G-protein coupled receptor protein signaling pathway|immune response	extracellular region					0						GGTCTTGTATCTCCTCTTCTC	0.527		NA											7	111					0.000673444	0.000745763	1	0
DLC1	10395	broad.mit.edu	37	8	13357323	13357323	+	Silent	SNP	G	G	A	rs146650078		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:13357323G>A	uc003wwm.2	-	2	702	c.258C>T	c.(256-258)GAC>GAT	p.D86D	DLC1_uc003wwn.2_Silent_p.D86D|DLC1_uc011kxy.1_Silent_p.D86D	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	86					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TGTCATTTTCGTCCACATCCT	0.443		NA											9	362					0	0	0	0
KIF13B	23303	broad.mit.edu	37	8	29025078	29025078	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:29025078T>A	uc003xhh.3	-	11	1029	c.970A>T	c.(970-972)ACC>TCC	p.T324S	KIF13B_uc003xhj.2_Missense_Mutation_p.T221S|KIF13B_uc010lvf.1_Missense_Mutation_p.T260S	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	324					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		ACCATGGCGGTCTTGCTGTTA	0.428		NA											50	66					0	0	0	0
FAM150A	389658	broad.mit.edu	37	8	53451006	53451006	+	Silent	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:53451006G>C	uc003xrd.2	-	4	592	c.387C>G	c.(385-387)ACC>ACG	p.T129T	FAM150A_uc011ldt.1_Intron	NM_207413	NP_997296	Q6UXT8	F150A_HUMAN	hypothetical protein LOC389658 precursor	129						extracellular region					0		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				AGTTTTGCTAGGTCTGGGAGC	0.264		NA											15	25					0	0	0	0
OPRK1	4986	broad.mit.edu	37	8	54142037	54142037	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:54142037G>T	uc003xrh.1	-	3	1338	c.963C>A	c.(961-963)ACC>ACA	p.T321T	OPRK1_uc003xri.1_Silent_p.T321T|OPRK1_uc010lyc.1_Silent_p.T232T	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	321	Helical; Name=7; (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GGCTACTGTTGGTATAGCCTA	0.517		NA											14	15					7.93e-07	9.81e-07	1	0
RP1	6101	broad.mit.edu	37	8	55542575	55542575	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:55542575G>T	uc003xsd.1	+	4	6281	c.6133G>T	c.(6133-6135)GGT>TGT	p.G2045C	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2045					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTTAGTTGTGGGTAATGTGGA	0.353		NA											25	53					2.28e-19	3.39e-19	1	0
PLAG1	5324	broad.mit.edu	37	8	57079634	57079634	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:57079634C>G	uc003xsq.3	-	3	1122	c.671G>C	c.(670-672)CGA>CCA	p.R224P	PLAG1_uc003xsr.3_Missense_Mutation_p.R224P|PLAG1_uc010lyi.2_Missense_Mutation_p.R224P|PLAG1_uc010lyj.2_Missense_Mutation_p.R142P	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	224	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.|C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GTGATCCTTTCGCCCAAATCT	0.478		NA	T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								36	46					0	0	0	0
TRIM55	84675	broad.mit.edu	37	8	67039550	67039550	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:67039550C>G	uc003xvv.2	+	1	273	c.47C>G	c.(46-48)ACC>AGC	p.T16S	TRIM55_uc003xvu.2_Missense_Mutation_p.T16S|TRIM55_uc003xvw.2_Missense_Mutation_p.T16S|TRIM55_uc003xvx.2_Missense_Mutation_p.T16S	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	16	RING-type.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GAGCAGCAGACCATGGATAAC	0.498		NA											41	74					0	0	0	0
E2F5	1875	broad.mit.edu	37	8	86114380	86114380	+	Splice_Site	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:86114380A>T	uc003ycz.3	+	2	272	c.235_splice	c.e2-2	p.A79_splice	E2F5_uc003yda.3_Splice_Site_p.A79_splice|E2F5_uc010mab.2_Splice_Site	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1						G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						TTTCCTGAACAGGCTGCTGAT	0.348		NA											5	20					0	0	0	0
CDH17	1015	broad.mit.edu	37	8	95183180	95183180	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:95183180A>C	uc003ygh.2	-	8	942	c.817T>G	c.(817-819)TTA>GTA	p.L273V	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Missense_Mutation_p.L273V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	273	Extracellular (Potential).|Cadherin 3.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTGTCAACTAAGGAATATTGT	0.453		NA											19	52					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	104897854	104897854	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:104897854C>T	uc003yls.2	+	2	602	c.361C>T	c.(361-363)CCA>TCA	p.P121S	RIMS2_uc003ylp.2_Missense_Mutation_p.P343S|RIMS2_uc003ylw.2_Missense_Mutation_p.P151S|RIMS2_uc003ylq.2_Missense_Mutation_p.P151S|RIMS2_uc003ylr.2_Missense_Mutation_p.P151S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	374					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCCCGTTATCCAGTAAAGCC	0.478		NA								HNSCC(12;0.0054)			15	30					0	0	0	0
TM7SF4	81501	broad.mit.edu	37	8	105360964	105360964	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:105360964G>A	uc003ylx.1	+	2	233	c.184G>A	c.(184-186)GCT>ACT	p.A62T		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	62	Helical; (Potential).|Poly-Ala.				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CATAGCGGCCGCTGCCTCCTG	0.507		NA											49	84					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113293570	113293570	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:113293570C>A	uc003ynu.2	-	59	9500	c.9341G>T	c.(9340-9342)TGT>TTT	p.C3114F	CSMD3_uc003yns.2_Missense_Mutation_p.C2316F|CSMD3_uc003ynt.2_Missense_Mutation_p.C3074F|CSMD3_uc011lhx.1_Missense_Mutation_p.C2945F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3114	Extracellular (Potential).|Sushi 23.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGGTTACCACACTGCACAGC	0.353		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	46					5.04e-11	6.9e-11	1	0
BAI1	575	broad.mit.edu	37	8	143623649	143623649	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:143623649A>T	uc003ywm.2	+	27	4237	c.4054A>T	c.(4054-4056)ACG>TCG	p.T1352S		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1352	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GCCCACGGCCACGGCCACGCT	0.652		NA											20	23					0	0	0	0
TIGD5	84948	broad.mit.edu	37	8	144681057	144681057	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:144681057G>T	uc003yyx.1	+	1	837	c.837G>T	c.(835-837)CTG>CTT	p.L279L	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	328					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GCCCGCTGCTGCGGGGCTGGT	0.697		NA											6	12					0.000157383	0.000180201	1	0
PLEC	5339	broad.mit.edu	37	8	145049407	145049407	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr8:145049407C>T	uc003zaj.2	-	2	180	c.131G>A	c.(130-132)GGT>GAT	p.G44D	PLEC_uc003zah.2_5'Flank	NM_000445	NP_000436	Q15149	PLEC_HUMAN	plectin isoform 1c	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCCAGCGCCACCCCCGCTGCG	0.657		NA									OREG0019050	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	50					0	0	0	0
FREM1	158326	broad.mit.edu	37	9	14812864	14812864	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:14812864C>G	uc003zlm.2	-	16	3429	c.2839G>C	c.(2839-2841)GAT>CAT	p.D947H	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	947	CSPG 6.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GAGAACTGATCCACTGTGACT	0.488		NA											70	147					0	0	0	0
C9orf135	138255	broad.mit.edu	37	9	72459432	72459432	+	Splice_Site	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:72459432G>T	uc004ahl.2	+	2	218	c.153_splice	c.e2-1	p.W51_splice	C9orf135_uc011lrw.1_Intron|C9orf135_uc010moq.2_Intron|C9orf135_uc011lrx.1_Intron|C9orf135_uc010mop.2_Splice_Site_p.W51_splice	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255							integral to membrane				ovary(1)	1						TTTTTCTTAAGGCACCGTGAC	0.328		NA											23	82					3.29e-13	4.61e-13	1	0
TMEM2	23670	broad.mit.edu	37	9	74360468	74360468	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:74360468T>C	uc011lsa.1	-	4	1040	c.500A>G	c.(499-501)GAT>GGT	p.D167G	TMEM2_uc010mos.2_Missense_Mutation_p.D167G|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	167	G8.					integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TCTGGATCCATCTTTATTGTC	0.423		NA											27	98					0	0	0	0
C9orf41	138199	broad.mit.edu	37	9	77599914	77599914	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:77599914T>A	uc004ajq.2	-	7	1190	c.1037A>T	c.(1036-1038)TAC>TTC	p.Y346F	uc004ajp.2_Intron|C9orf41_uc011lsi.1_RNA	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	346										ovary(1)|skin(1)	2						TTCAAAGTGGTACAGCAGAGG	0.348		NA											26	69					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608996	84608996	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:84608996T>C	uc004amn.2	+	4	3658	c.3611T>C	c.(3610-3612)ATG>ACG	p.M1204T		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1204						integral to membrane					0						AAAAATCAGATGTTGAGCCAG	0.393		NA											25	98					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84610013	84610013	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:84610013C>G	uc004amn.2	+	4	4675	c.4628C>G	c.(4627-4629)CCA>CGA	p.P1543R		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1543						integral to membrane					0						CCAGCCGTCCCAACCAGTGCT	0.527		NA											5	26					0	0	0	0
OR13C5	138799	broad.mit.edu	37	9	107360955	107360955	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:107360955A>C	uc011lvp.1	-	1	740	c.740T>G	c.(739-741)GTG>GGG	p.V247G		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGTTATCACCACAGTCAGACG	0.423		NA											23	77					0	0	0	0
SVEP1	79987	broad.mit.edu	37	9	113261433	113261433	+	Silent	SNP	C	C	T	rs3737156	by1000genomes	TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:113261433C>T	uc010mtz.2	-	7	1906	c.1569G>A	c.(1567-1569)ACG>ACA	p.T523T	SVEP1_uc010mua.1_Silent_p.T523T|SVEP1_uc004beu.2_Silent_p.T523T	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	523	Sushi 3.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CATAGCAGATCGTCCCAAATT	0.488		NA											18	44					0	0	0	0
PAPPA	5069	broad.mit.edu	37	9	118950444	118950444	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:118950444C>G	uc004bjn.2	+	2	1808	c.1427C>G	c.(1426-1428)CCT>CGT	p.P476R	PAPPA_uc011lxp.1_Missense_Mutation_p.P269R|PAPPA_uc011lxq.1_Missense_Mutation_p.P269R	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	476	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TGCTGTGACCCTGAAATCACC	0.507		NA											13	44					0	0	0	0
C5	727	broad.mit.edu	37	9	123776180	123776180	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:123776180G>C	uc004bkv.2	-	17	2258	c.2228C>G	c.(2227-2229)TCT>TGT	p.S743C	C5_uc010mvm.1_Missense_Mutation_p.S743C	NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	743					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	GTCTTTATGAGAGATATTAGC	0.423		NA											42	125					0	0	0	0
MRRF	92399	broad.mit.edu	37	9	125084837	125084837	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:125084837G>A	uc004bmb.2	+	7	845	c.730G>A	c.(730-732)GAC>AAC	p.D244N	MRRF_uc004bmc.2_Missense_Mutation_p.M190I|MRRF_uc010mwa.2_Missense_Mutation_p.D244N|MRRF_uc011lyr.1_Missense_Mutation_p.D192N|MRRF_uc004bmd.2_Missense_Mutation_p.D244N|MRRF_uc004bme.2_RNA	NM_138777	NP_620132	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor isoform	244					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						AATGGCCGATGACACAGTGGC	0.493		NA											7	33					0	0	0	0
GOLGA1	2800	broad.mit.edu	37	9	127670691	127670691	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:127670691T>C	uc004bpc.2	-	12	1372	c.1030A>G	c.(1030-1032)AGC>GGC	p.S344G	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	344	Potential.					Golgi cisterna membrane				ovary(1)	1						TTAGCCTGGCTGCTTCTGGCT	0.463		NA											33	130					0	0	0	0
C9orf98	158067	broad.mit.edu	37	9	135602855	135602855	+	Silent	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:135602855T>A	uc004cbu.1	-	12	1744	c.1188A>T	c.(1186-1188)CCA>CCT	p.P396P	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Silent_p.P192P	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	396	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		CCCCAGTGACTGGATCAATTC	0.463		NA											34	113					0	0	0	0
SARDH	1757	broad.mit.edu	37	9	136597649	136597649	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:136597649C>T	uc004cep.3	-	3	540	c.406G>A	c.(406-408)GAG>AAG	p.E136K	SARDH_uc004ceo.2_Missense_Mutation_p.E136K|SARDH_uc011mdn.1_Missense_Mutation_p.E136K|SARDH_uc011mdo.1_5'UTR	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	136					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TCCTCCAGCTCCCGGCTCACC	0.672		NA											29	139					0	0	0	0
SARDH	1757	broad.mit.edu	37	9	136599210	136599210	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:136599210G>C	uc004cep.3	-	2	220	c.86C>G	c.(85-87)TCC>TGC	p.S29C	SARDH_uc004ceo.2_Missense_Mutation_p.S29C|SARDH_uc011mdn.1_Missense_Mutation_p.S29C|SARDH_uc011mdo.1_Intron	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	29					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		AGCTGCGCTGGACAGGTTGCA	0.697		NA											8	35					0	0	0	0
COL5A1	1289	broad.mit.edu	37	9	137653806	137653806	+	Silent	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:137653806G>C	uc004cfe.2	+	19	2353	c.1971G>C	c.(1969-1971)CCG>CCC	p.P657P		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	657	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CAGGACCTCCGGGAGACGATG	0.597		NA											23	81					0	0	0	0
CLIC3	9022	broad.mit.edu	37	9	139889998	139889998	+	Silent	SNP	G	G	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:139889998G>A	uc004ckj.1	-	3	194	c.165C>T	c.(163-165)GAC>GAT	p.D55D		NM_004669	NP_004660	O95833	CLIC3_HUMAN	chloride intracellular channel 3	55	GST N-terminal.|Required for insertion into the membrane (By similarity).				signal transduction	chloride channel complex|cytoplasm|nucleus	protein binding|voltage-gated chloride channel activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGGGGCGAAGTCCTTCAGCA	0.697		NA											13	64					0	0	0	0
PIGA	5277	broad.mit.edu	37	X	15349561	15349561	+	Silent	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:15349561C>G	uc004cwr.2	-	2	592	c.492G>C	c.(490-492)TCG>TCC	p.S164S	PIGA_uc004cwq.2_Intron|PIGA_uc010nev.2_Intron|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Intron	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	164	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					TTGTAAGCACCGAGCTGACAT	0.443		NA											24	24					0	0	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29414435	29414435	+	Silent	SNP	A	A	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:29414435A>T	uc004dby.2	+	4	931	c.423A>T	c.(421-423)GGA>GGT	p.G141G		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	141	Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						ATGACACTGGACTCTGCTATA	0.388		NA											35	26					0	0	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254123	30254123	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:30254123G>T	uc004dca.1	+	5	819	c.82G>T	c.(82-84)GCT>TCT	p.A28S		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	28											0						TCACCAGGGTGCTCAGATCAC	0.517		NA											16	23					1.15e-07	1.46e-07	1	0
MAGEB3	4114	broad.mit.edu	37	X	30254946	30254946	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:30254946C>G	uc004dca.1	+	5	1642	c.905C>G	c.(904-906)GCG>GGG	p.A302G		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	302	MAGE.										0						GTCCCCAGTGCGTTCCAGTTC	0.502		NA											22	18					0	0	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269234	30269234	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:30269234C>A	uc004dcc.2	+	4	944	c.624C>A	c.(622-624)ATC>ATA	p.I208I	MAGEB1_uc004dcd.2_Silent_p.I208I|MAGEB1_uc004dce.2_Silent_p.I208I	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	208	MAGE.										0						TGGGTGTGATCTTCTTAAAGG	0.493		NA											3	7					0.004672	0.00498285	1	0
CXorf22	170063	broad.mit.edu	37	X	35989850	35989850	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:35989850G>T	uc004ddj.2	+	12	2177	c.2118G>T	c.(2116-2118)AGG>AGT	p.R706S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	706										large_intestine(1)|lung(1)|ovary(1)	3						TAACCACCAGGGGTATAGCAT	0.418		NA											16	32					0.00316338	0.00341434	1	0
ZNF630	57232	broad.mit.edu	37	X	47919477	47919477	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:47919477G>C	uc004div.3	-	5	606	c.354C>G	c.(352-354)ATC>ATG	p.I118M	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Translation_Start_Site	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						CAATATGCCAGATTTTTAAAA	0.373		NA											5	5					0	0	0	0
PJA1	64219	broad.mit.edu	37	X	68382107	68382107	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:68382107T>A	uc004dxh.2	-	2	1261	c.975A>T	c.(973-975)AAA>AAT	p.K325N	PJA1_uc011mpi.1_Missense_Mutation_p.K43N|PJA1_uc004dxg.2_Missense_Mutation_p.K137N|PJA1_uc004dxi.2_Missense_Mutation_p.K270N	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	325							zinc ion binding				0						TCGCTTCCCGTTTGTCTTCAG	0.552		NA											17	18					0	0	0	0
MED12	9968	broad.mit.edu	37	X	70340889	70340889	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:70340889G>T	uc004dyy.2	+	5	821	c.622G>T	c.(622-624)GGG>TGG	p.G208W	MED12_uc011mpq.1_Missense_Mutation_p.G208W|MED12_uc004dyz.2_Missense_Mutation_p.G208W|MED12_uc004dza.2_Missense_Mutation_p.G55W	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	208					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CTACCGGCCAGGGCCTGCAGG	0.532		NA											31	25					2.46e-21	3.7e-21	1	0
KIAA2022	340533	broad.mit.edu	37	X	73963450	73963450	+	Silent	SNP	A	A	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:73963450A>G	uc004eby.2	-	3	1559	c.942T>C	c.(940-942)TAT>TAC	p.Y314Y		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	314					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GAAAGGATTCATATCGAATTT	0.418		NA											47	50					0	0	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004401	75004401	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:75004401G>T	uc004ecj.1	-	1	671	c.486C>A	c.(484-486)TTC>TTA	p.F162L		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	162	MAGE 1.									ovary(1)|skin(1)	2						CGGTGATCTGGAAACCCCGTT	0.527		NA											10	12					5.17e-11	7.07e-11	1	0
TBX22	50945	broad.mit.edu	37	X	79281194	79281194	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:79281194G>T	uc010nmg.1	+	5	685	c.551G>T	c.(550-552)TGC>TTC	p.C184F	TBX22_uc004edi.1_Missense_Mutation_p.C64F|TBX22_uc004edj.1_Missense_Mutation_p.C184F	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	184	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						GACTCACCCTGCTCGGGAGAG	0.488		NA											15	22					6.72e-11	9.18e-11	1	0
PABPC5	140886	broad.mit.edu	37	X	90691137	90691137	+	Silent	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:90691137G>T	uc004efg.2	+	2	1001	c.561G>T	c.(559-561)GCG>GCT	p.A187A	PABPC5_uc004eff.1_Silent_p.A23A	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	187						cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						AAGAGCGGGCGGCTGAGGTCA	0.493		NA											21	12					8.34e-07	1.03e-06	1	0
PABPC5	140886	broad.mit.edu	37	X	90691163	90691163	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:90691163C>A	uc004efg.2	+	2	1027	c.587C>A	c.(586-588)GCA>GAA	p.A196E	PABPC5_uc004eff.1_Missense_Mutation_p.A32E	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	196						cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						AGGGATAGAGCAACTTTCACC	0.458		NA											20	22					1.56e-12	2.18e-12	1	0
PCDH11X	27328	broad.mit.edu	37	X	91134249	91134249	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:91134249C>T	uc004efk.1	+	2	3855	c.3010C>T	c.(3010-3012)CCT>TCT	p.P1004S	PCDH11X_uc004efl.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efo.1_Missense_Mutation_p.P1004S|PCDH11X_uc010nmv.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efm.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efn.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efh.1_Missense_Mutation_p.P1004S|PCDH11X_uc004efj.1_Missense_Mutation_p.P1004S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1004	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTTCGAGGTACCTGTGTCCGT	0.423		NA											44	72					0	0	0	0
USP26	83844	broad.mit.edu	37	X	132162179	132162179	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:132162179C>G	uc010nrm.1	-	6	540	c.70G>C	c.(70-72)GAA>CAA	p.E24Q	USP26_uc011mvf.1_Missense_Mutation_p.E24Q	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	24					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					ATGAATGCTTCTTTTGACTTA	0.358		NA											37	37					0	0	0	0
DDX26B	203522	broad.mit.edu	37	X	134680705	134680705	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:134680705G>T	uc004eyw.3	+	5	871	c.508G>T	c.(508-510)GCC>TCC	p.A170S		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	170	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGTTATTTGCCCTGGTGTT	0.468		NA											44	50					1.76e-25	2.7e-25	1	0
CDR1	1038	broad.mit.edu	37	X	139866414	139866414	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:139866414G>T	uc004fbg.1	-	1	310	c.118C>A	c.(118-120)CTG>ATG	p.L40M	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	40	7.|23 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				ATGTCTTCCAGCCTACTTGTG	0.438		NA											50	52					4.45e-29	6.9e-29	1	0
MAGEC1	9947	broad.mit.edu	37	X	140994309	140994309	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:140994309C>A	uc004fbt.2	+	4	1405	c.1119C>A	c.(1117-1119)CTC>CTA	p.L373L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	373							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCTCCTCTCCAGATTCCTG	0.478		NA								HNSCC(15;0.026)			90	104					7.49e-41	1.19e-40	1	0
MAGEC1	9947	broad.mit.edu	37	X	140995492	140995492	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:140995492G>C	uc004fbt.2	+	4	2588	c.2302G>C	c.(2302-2304)GAG>CAG	p.E768Q	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	768							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTCCTCCTGAGGGGCCTGC	0.537		NA								HNSCC(15;0.026)			98	122					0	0	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995643	140995643	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:140995643C>A	uc004fbt.2	+	4	2739	c.2453C>A	c.(2452-2454)CCC>CAC	p.P818H	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	818							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGCTCCTTCCCCTCCTCCACT	0.552		NA								HNSCC(15;0.026)			106	124					1.52e-35	2.4e-35	1	0
SLITRK4	139065	broad.mit.edu	37	X	142716466	142716466	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:142716466C>A	uc004fbx.2	-	2	2835	c.2459G>T	c.(2458-2460)AGT>ATT	p.S820I	SLITRK4_uc004fby.2_Missense_Mutation_p.S820I	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	820	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GTCAGGGGAACTCTGCAGTTT	0.393		NA											45	42					3.86e-14	5.48e-14	1	0
SLITRK4	139065	broad.mit.edu	37	X	142717845	142717845	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:142717845G>T	uc004fbx.2	-	2	1456	c.1080C>A	c.(1078-1080)AAC>AAA	p.N360K	SLITRK4_uc004fby.2_Missense_Mutation_p.N360K	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	360	Extracellular (Potential).|LRRNT.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCTTGGCAGTTCACACTTA	0.458		NA											71	67					1.35e-36	2.12e-36	1	0
SPANXN1	494118	broad.mit.edu	37	X	144337280	144337280	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:144337280C>A	uc004fcb.2	+	2	165	c.165C>A	c.(163-165)TGC>TGA	p.C55*		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein	55											0	Acute lymphoblastic leukemia(192;6.56e-05)					TAGCGTTTTGCTACAGGAAAG	0.433		NA											39	32					1.42e-22	2.15e-22	1	0
L1CAM	3897	broad.mit.edu	37	X	153134316	153134316	+	Silent	SNP	C	C	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:153134316C>A	uc004fjb.2	-	11	1467	c.1359G>T	c.(1357-1359)GCG>GCT	p.A453A	L1CAM_uc004fjc.2_Silent_p.A453A|L1CAM_uc010nuo.2_Silent_p.A448A|L1CAM_uc004fjd.1_Silent_p.A267A	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	453	Extracellular (Potential).|Ig-like C2-type 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGGCACAGGCGCTCCGAAGG	0.632		NA											46	48					2.31e-15	3.32e-15	1	0
STAB2	55576	broad.mit.edu	37	12	104106206	104106206	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr12:104106206delG	uc001tjw.2	+	41	4582	c.4396delG	c.(4396-4398)GGGfs	p.G1466fs	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1466	Extracellular (Potential).|EGF-like 11.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCAAGGAAACGGGACCATCTG	0.512		NA											35	97	---	---	---	---	NA	NA	NA	NA
OR4K14	122740	broad.mit.edu	37	14	20482615	20482616	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr14:20482615_20482616insA	uc010tky.1	-	1	737_738	c.737_738insT	c.(736-738)ATGfs	p.M246fs		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GCGTCACTACCATGATATGTGC	0.49		NA											9	33	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578474	7578474	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr17:7578474delC	uc002gim.2	-	5	650	c.456delG	c.(454-456)CCGfs	p.P152fs	TP53_uc002gig.1_Frame_Shift_Del_p.P152fs|TP53_uc002gih.2_Frame_Shift_Del_p.P152fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.P20fs|TP53_uc010cng.1_Frame_Shift_Del_p.P20fs|TP53_uc002gii.1_Frame_Shift_Del_p.P20fs|TP53_uc010cnh.1_Frame_Shift_Del_p.P152fs|TP53_uc010cni.1_Frame_Shift_Del_p.P152fs|TP53_uc002gij.2_Frame_Shift_Del_p.P152fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.P59fs|TP53_uc002gio.2_Frame_Shift_Del_p.P20fs|TP53_uc010vug.1_Frame_Shift_Del_p.P113fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	152	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(57)|p.P152S(21)|p.P152fs*18(17)|p.P153fs*28(8)|p.P152T(7)|p.0?(7)|p.P152fs*29(5)|p.P152P(5)|p.P152Q(4)|p.P152fs*14(4)|p.P152fs*28(3)|p.P152R(3)|p.T150fs*16(3)|p.P152A(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.G154fs*16(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*20(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.G154fs*27(1)|p.P152_P153insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGTGCCGGGCGGGGGTGTGG	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	52	---	---	---	---	NA	NA	NA	NA
C19orf41	126123	broad.mit.edu	37	19	50666294	50666295	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr19:50666294_50666295delGC	uc002prp.1	-	1	244_245	c.157_158delGC	c.(157-159)GCCfs	p.A53fs		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	53	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		CACGGCCCCGGCGCGCGCCTGC	0.668		NA											13	37	---	---	---	---	NA	NA	NA	NA
CCNT2	905	broad.mit.edu	37	2	135711427	135711427	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr2:135711427delG	uc002tuc.1	+	9	1434	c.1402delG	c.(1402-1404)GGGfs	p.G468fs	CCNT2_uc002tub.1_Frame_Shift_Del_p.G468fs|CCNT2_uc010zbf.1_Frame_Shift_Del_p.G293fs|CCNT2_uc002tud.1_Frame_Shift_Del_p.G131fs	NM_058241	NP_490595	O60583	CCNT2_HUMAN	cyclin T2 isoform b	468					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			ovary(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.107)		GCACAAACAAGGGCAGTCACA	0.388		NA											13	71	---	---	---	---	NA	NA	NA	NA
GZF1	64412	broad.mit.edu	37	20	23346248	23346248	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr20:23346248delG	uc010gdb.2	+	3	1402	c.1228delG	c.(1228-1230)GGCfs	p.G410fs	GZF1_uc002wsy.2_Frame_Shift_Del_p.G410fs|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_Frame_Shift_Del_p.G410fs	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	410	C2H2-type 4.				transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					GCACCGCTGCGGCCAGTGCGG	0.682		NA											27	78	---	---	---	---	NA	NA	NA	NA
CEP70	80321	broad.mit.edu	37	3	138289944	138289944	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:138289944delC	uc003esl.2	-	5	414	c.216delG	c.(214-216)TTGfs	p.L72fs	CEP70_uc011bmk.1_Frame_Shift_Del_p.L52fs|CEP70_uc011bml.1_Frame_Shift_Del_p.L54fs|CEP70_uc011bmm.1_Intron|CEP70_uc003esm.2_Frame_Shift_Del_p.L72fs|CEP70_uc003esn.2_Frame_Shift_Del_p.L72fs	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	72					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						CTTCCACCAACAATTTCAAAT	0.303		NA											9	75	---	---	---	---	NA	NA	NA	NA
PLSCR5	389158	broad.mit.edu	37	3	146307593	146307593	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr3:146307593delG	uc003ewb.2	-	6	1628	c.624delC	c.(622-624)ACCfs	p.T208fs	PLSCR5_uc010hvb.2_Frame_Shift_Del_p.T196fs|PLSCR5_uc010hvc.2_Frame_Shift_Del_p.T208fs	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	208											0						TTTCATTAATGGTTTTCACCT	0.318		NA											22	138	---	---	---	---	NA	NA	NA	NA
SLC12A2	6558	broad.mit.edu	37	5	127510346	127510348	+	In_Frame_Del	DEL	ATT	ATT	-	rs149957408		TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr5:127510346_127510348delATT	uc003kus.2	+	20	3081_3083	c.2917_2919delATT	c.(2917-2919)ATTdel	p.I973del	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_In_Frame_Del_p.I973del	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	973	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGAAAAACCAATTACACACAAAG	0.271		NA											16	39	---	---	---	---	NA	NA	NA	NA
SCAND3	114821	broad.mit.edu	37	6	28539885	28539886	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:28539885_28539886insA	uc003nlo.2	-	4	4398_4399	c.3780_3781insT	c.(3778-3783)CTTGCTfs	p.L1260fs		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1260_1261					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						gcaatctcagcaagctcaggat	0		NA											19	83	---	---	---	---	NA	NA	NA	NA
TULP4	56995	broad.mit.edu	37	6	158914657	158914658	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr6:158914657_158914658delCT	uc003qrf.2	+	10	3041_3042	c.1684_1685delCT	c.(1684-1686)CTCfs	p.L562fs	TULP4_uc003qrg.2_Frame_Shift_Del_p.L562fs	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	562					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TGCTCAGGAGCTCTCCCGGTCC	0.649		NA											24	63	---	---	---	---	NA	NA	NA	NA
OGDH	4967	broad.mit.edu	37	7	44736099	44736100	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr7:44736099_44736100delAC	uc003tln.2	+	14	1952_1953	c.1843_1844delAC	c.(1843-1845)ACAfs	p.T615fs	OGDH_uc011kbx.1_Frame_Shift_Del_p.T611fs|OGDH_uc011kby.1_Frame_Shift_Del_p.T465fs|OGDH_uc003tlp.2_Frame_Shift_Del_p.T626fs|OGDH_uc011kbz.1_Frame_Shift_Del_p.T410fs|OGDH_uc003tlo.1_Frame_Shift_Del_p.T448fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	615					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GGATATTCTGACACACATCGGG	0.545		NA											21	60	---	---	---	---	NA	NA	NA	NA
CDKN2A	1029	broad.mit.edu	37	9	21974693	21974693	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:21974693delC	uc003zpk.2	-	1	346	c.134delG	c.(133-135)GGTfs	p.G45fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Frame_Shift_Del_p.G45fs|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	45	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(25)|p.G45fs*8(3)|p.G45D(2)|p.G45S(1)|p.V28_V51del(1)|p.G45del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGGCCTCCGACCGTAACTATT	0.687		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			56	100	---	---	---	---	NA	NA	NA	NA
RPL12	6136	broad.mit.edu	37	9	130210254	130210255	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chr9:130210254_130210255delTC	uc004bqy.1	-	6	481_482	c.393_394delGA	c.(391-396)GAGATCfs	p.E131fs	RPL12_uc004bqx.1_RNA|RPL12_uc004bqz.1_Frame_Shift_Del_p.E98fs	NM_000976	NP_000967	P30050	RL12_HUMAN	ribosomal protein L12	131_132					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						GTCCCCAGGATCTCTTTAATGG	0.505		NA											12	92	---	---	---	---	NA	NA	NA	NA
DACH2	117154	broad.mit.edu	37	X	86069720	86069720	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:86069720delA	uc004eew.2	+	10	1737	c.1567delA	c.(1567-1569)AAAfs	p.K523fs	DACH2_uc004eex.2_Frame_Shift_Del_p.K510fs|DACH2_uc010nmq.2_Frame_Shift_Del_p.K389fs|DACH2_uc011mra.1_Frame_Shift_Del_p.K356fs|DACH2_uc010nmr.2_Frame_Shift_Del_p.K304fs|DACH2_uc004eey.2_Frame_Shift_Del_p.K216fs|DACH2_uc004eez.2_Frame_Shift_Del_p.K206fs	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	523	Potential.|DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						GAAGAAGGAGAAAAAAACCAA	0.428		NA											16	18	---	---	---	---	NA	NA	NA	NA
TSPAN6	7105	broad.mit.edu	37	X	99890221	99890221	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:99890221delA	uc004ega.1	-	3	408	c.305delT	c.(304-306)TTGfs	p.L102fs	TSPAN6_uc010nna.1_Frame_Shift_Del_p.L8fs	NM_003270	NP_003261	O43657	TSN6_HUMAN	transmembrane 4 superfamily member 6	102	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			ovary(1)	1						CAGTTCGACCAAAAAAACGAG	0.393		NA											11	7	---	---	---	---	NA	NA	NA	NA
PLXNB3	5365	broad.mit.edu	37	X	153034499	153034499	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-5360-01A-01D-1434-08	TCGA-CN-5360-10A-01D-1434-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	174f1ea8-abcf-44ee-b17b-9687b3ab6dae	a0cd5de0-863d-4f83-b9c5-949162c0963c	g.chrX:153034499delG	uc004fii.2	+	5	1537	c.1363delG	c.(1363-1365)GGCfs	p.G455fs	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Frame_Shift_Del_p.G137fs|PLXNB3_uc010nuk.2_Frame_Shift_Del_p.G478fs|PLXNB3_uc011mzd.1_Frame_Shift_Del_p.G94fs	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	455	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GGACAGCAGTGGCAGTCACCT	0.642		NA											27	22	---	---	---	---	NA	NA	NA	NA