Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PIK3CD	5293	broad.mit.edu	37	1	9784117	9784117	+	Silent	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:9784117C>T	uc001aqb.3	+	21	2893	c.2685C>T	c.(2683-2685)CAC>CAT	p.H895H	PIK3CD_uc010oaf.1_Silent_p.H894H|PIK3CD_uc001aqe.3_Silent_p.H919H	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	895	PI3K/PI4K.				phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GCGATCGGCACAGCGACAACA	0.632		NA											57	54					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91727880	91727880	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:91727880C>T	uc001doa.3	-	38	4256	c.4156G>A	c.(4156-4158)GAA>AAA	p.E1386K	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.E1065K|HFM1_uc001dob.3_Missense_Mutation_p.E574K	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1386							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GGGTTTTTTTCAGAGAAAGTA	0.284		NA											10	58					0	0	0	0
HFM1	164045	broad.mit.edu	37	1	91728133	91728133	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:91728133C>G	uc001doa.3	-	37	4091	c.3991G>C	c.(3991-3993)GAG>CAG	p.E1331Q	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.E1010Q|HFM1_uc001dob.3_Missense_Mutation_p.E519Q	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1331							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TCCGACATCTCATGTGATGAA	0.303		NA											8	59					0	0	0	0
FAM102B	284611	broad.mit.edu	37	1	109167328	109167328	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:109167328A>G	uc010ouy.1	+	6	594	c.514A>G	c.(514-516)AGA>GGA	p.R172G		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	172										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		GCAAGAAGATAGAAAAGGTGG	0.423		NA											26	39					0	0	0	0
MEX3A	92312	broad.mit.edu	37	1	156046882	156046882	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:156046882G>A	uc001fnd.3	-	2	1046	c.1046C>T	c.(1045-1047)TCT>TTT	p.S349F		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	349						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					CTCAAAGCCAGAGTCCACTCC	0.672		NA											6	84					0	0	0	0
FCGR2B	2213	broad.mit.edu	37	1	161642856	161642856	+	Silent	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:161642856C>G	uc001gaz.1	+	4	575	c.483C>G	c.(481-483)GTC>GTG	p.V161V	FCGR2B_uc009wum.1_Silent_p.V161V|FCGR2B_uc001gay.1_Silent_p.V160V|FCGR2B_uc001gba.1_Silent_p.V160V|FCGR2B_uc001gbb.1_Silent_p.V161V|FCGR2B_uc009wun.1_Silent_p.V154V	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	161	Ig-like C2-type 2.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGCCTCTGGTCAAGGTCACAT	0.522		NA	T	?	ALL								7	22					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197091047	197091047	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:197091047G>A	uc001gtu.2	-	16	4125	c.3868C>T	c.(3868-3870)CAG>TAG	p.Q1290*	ASPM_uc001gtv.2_Nonsense_Mutation_p.Q1290*|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1290					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGGAGTACCTGATGGCGTTTG	0.318		NA											4	61					0	0	0	0
FMN2	56776	broad.mit.edu	37	1	240256692	240256692	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:240256692C>T	uc010pyd.1	+	1	1508	c.1283C>T	c.(1282-1284)TCG>TTG	p.S428L	FMN2_uc010pye.1_Missense_Mutation_p.S428L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	428					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGCTCAGCTCGCCCAATCAC	0.667		NA											6	64					0	0	0	0
EXO1	9156	broad.mit.edu	37	1	242016725	242016725	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:242016725G>C	uc001hzh.2	+	6	887	c.347G>C	c.(346-348)CGA>CCA	p.R116P	EXO1_uc001hzi.2_Missense_Mutation_p.R116P|EXO1_uc001hzj.2_Missense_Mutation_p.R116P|EXO1_uc009xgq.2_Missense_Mutation_p.R116P	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	116					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TCGGAAGCTCGAGAGTGTTTC	0.423		NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					12	85					0	0	0	0
C1orf101	257044	broad.mit.edu	37	1	244641251	244641251	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr1:244641251G>A	uc001iam.2	+	4	291	c.232G>A	c.(232-234)GCT>ACT	p.A78T	C1orf101_uc001iak.1_5'UTR|C1orf101_uc001ial.2_Missense_Mutation_p.A78T|C1orf101_uc010pym.1_5'UTR|C1orf101_uc010pyn.1_Missense_Mutation_p.A81T	NM_001130957	NP_001124429	Q5SY80	CA101_HUMAN	hypothetical protein LOC257044 isoform 1	78	Extracellular (Potential).					integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			TGGTGTTCACGCTATAAAACC	0.318		NA											6	84					0	0	0	0
DIP2C	22982	broad.mit.edu	37	10	445090	445090	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:445090C>T	uc001ifp.2	-	10	1309	c.1219G>A	c.(1219-1221)GAG>AAG	p.E407K	DIP2C_uc009xhj.1_Missense_Mutation_p.E103K	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	407						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGACCACCTCGGCCAGCAGG	0.617		NA											5	33					0	0	0	0
ITGA8	8516	broad.mit.edu	37	10	15649678	15649678	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:15649678G>A	uc001ioc.1	-	17	1762	c.1762C>T	c.(1762-1764)CGA>TGA	p.R588*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.R573*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	588	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ATACTTACTCGAAGGTAAACG	0.448		NA											24	222					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16882891	16882891	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:16882891G>A	uc001ioo.2	-	61	9871	c.9819C>T	c.(9817-9819)ATC>ATT	p.I3273I		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3273	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CACTGTCCATGATGGTGTATG	0.343		NA											8	41					0	0	0	0
ZNF485	220992	broad.mit.edu	37	10	44112550	44112550	+	Silent	SNP	G	G	A	rs141606024	byFrequency	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:44112550G>A	uc010qfc.1	+	5	1253	c.1059G>A	c.(1057-1059)CCG>CCA	p.P353P	ZNF485_uc010qfd.1_Silent_p.P262P	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	353					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAATAAACCGTATCAGTGTC	0.418		NA											4	80					0	0	0	0
CXCL12	6387	broad.mit.edu	37	10	44876302	44876302	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:44876302A>G	uc001jbf.2	-	2	177	c.88T>C	c.(88-90)TGC>CGC	p.C30R	CXCL12_uc001jbh.2_Missense_Mutation_p.C30R|CXCL12_uc001jbi.2_Missense_Mutation_p.C30R	NM_000609	NP_000600	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12 (stromal	30					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity				0					Dexamethasone(DB01234)	CGGCATGGGCATCTGTAGCTC	0.493		NA											18	136					0	0	0	0
ERCC6	2074	broad.mit.edu	37	10	50732560	50732560	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:50732560C>A	uc001jhs.3	-	5	1070	c.916G>T	c.(916-918)GCC>TCC	p.A306S	PGBD3_uc001jht.2_5'Flank|PGBD3_uc009xoe.2_Missense_Mutation_p.A306S|PGBD3_uc001jhu.2_Missense_Mutation_p.A306S	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	306					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TGCACTGGGGCTGGAGGCGTG	0.428		NA						Direct_reversal_of_damage|NER					66	110					5.01e-31	6.22e-31	1	0
PPRC1	23082	broad.mit.edu	37	10	103900410	103900410	+	Silent	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:103900410C>T	uc001kum.2	+	5	2184	c.2145C>T	c.(2143-2145)TCC>TCT	p.S715S	PPRC1_uc001kun.2_Silent_p.S595S|PPRC1_uc010qqj.1_Silent_p.S715S|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	715					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGTCAGAGTCCTTGGACCCAC	0.532		NA											8	61					0	0	0	0
SORCS1	114815	broad.mit.edu	37	10	108923927	108923927	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr10:108923927G>A	uc001kym.2	-	1	366	c.358C>T	c.(358-360)CGG>TGG	p.R120W	SORCS1_uc001kyl.2_Missense_Mutation_p.R120W|SORCS1_uc009xxs.2_Missense_Mutation_p.R120W|SORCS1_uc001kyn.1_Missense_Mutation_p.R120W|SORCS1_uc001kyo.2_Missense_Mutation_p.R120W	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	120	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCCTCTCCCCGTTCTGCCTTC	0.701		NA											5	28					0	0	0	0
ANO3	63982	broad.mit.edu	37	11	26529794	26529794	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:26529794G>C	uc001mqt.3	+	5	721	c.576G>C	c.(574-576)TTG>TTC	p.L192F	ANO3_uc010rdr.1_Missense_Mutation_p.L176F|ANO3_uc010rds.1_Missense_Mutation_p.L46F|ANO3_uc010rdt.1_Missense_Mutation_p.L46F	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	192	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAGAAGGCTTGATGTTGGAGA	0.299		NA											19	20					0	0	0	0
OR4C3	256144	broad.mit.edu	37	11	48346829	48346829	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:48346829G>A	uc010rhv.1	+	1	337	c.337G>A	c.(337-339)GAG>AAG	p.E113K		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTCATTGTATGAGGGGAGAAC	0.443		NA											10	204					0	0	0	0
OR5J2	282775	broad.mit.edu	37	11	55944828	55944828	+	Silent	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:55944828G>T	uc010rjb.1	+	1	735	c.735G>T	c.(733-735)CTG>CTT	p.L245L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					CCTCTCACCTGACTGCTGTGA	0.438		NA											10	77					3.86e-05	4.35e-05	1	0
OR5T2	219464	broad.mit.edu	37	11	56000661	56000661	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:56000661T>C	uc010rjc.1	-	1	1	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CTGTACGACATATATTCAGCA	0.373		NA											42	52					0	0	0	0
PPFIA1	8500	broad.mit.edu	37	11	70172809	70172809	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:70172809G>C	uc001opo.2	+	7	1013	c.815G>C	c.(814-816)CGC>CCC	p.R272P	PPFIA1_uc001opn.1_Missense_Mutation_p.R272P|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	272	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			ATGAAAGAACGCCTGGCTTCC	0.423		NA											54	876					0	0	0	0
DDX10	1662	broad.mit.edu	37	11	108788633	108788633	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr11:108788633A>G	uc001pkm.2	+	17	2403	c.2338A>G	c.(2338-2340)AGT>GGT	p.S780G	DDX10_uc001pkl.1_Missense_Mutation_p.S780G	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	780							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TCTGGATTGGAGtgatgatga	0.318		NA	T	NUP98	AML*								3	65					0	0	0	0
SLC6A13	6540	broad.mit.edu	37	12	333173	333173	+	Silent	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:333173C>G	uc001qic.1	-	11	1349	c.1296G>C	c.(1294-1296)CTG>CTC	p.L432L	SLC6A13_uc009zdj.1_Silent_p.L422L|SLC6A13_uc010sdl.1_Silent_p.L340L	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	432	Helical; Name=9; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TGAGCATGATCAGCCCCACAA	0.592		NA											4	60					0	0	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091182	11091182	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:11091182G>C	uc010shi.1	-	1	625	c.625C>G	c.(625-627)CGC>GGC	p.R209G	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_023922	NP_076411	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	209	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity				0						ATCTTCTTGCGATGTTTCCAC	0.433		NA											12	59					0	0	0	0
C12orf60	144608	broad.mit.edu	37	12	14976222	14976222	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:14976222C>T	uc001rcj.3	+	2	557	c.353C>T	c.(352-354)GCC>GTC	p.A118V		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	118										ovary(1)|central_nervous_system(1)	2						TTCAAAAGTGCCCATACGCCA	0.428		NA											5	103					0	0	0	0
PDE3A	5139	broad.mit.edu	37	12	20769270	20769270	+	Missense_Mutation	SNP	G	G	A	rs141325069	byFrequency	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:20769270G>A	uc001reh.1	+	4	1398	c.1376G>A	c.(1375-1377)CGG>CAG	p.R459Q		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	459					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GCACCAGTACGGAGAGACCGC	0.542		NA											8	89					0	0	0	0
KRT77	374454	broad.mit.edu	37	12	53086338	53086338	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:53086338C>G	uc001saw.2	-	7	1323	c.1294G>C	c.(1294-1296)GAG>CAG	p.E432Q	KRT77_uc009zmi.2_Missense_Mutation_p.E190Q	NM_175078	NP_778253	Q7Z794	K2C1B_HUMAN	keratin 77	432	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(1)	1						AGGGCCTCCTCCAGGTCCTGC	0.622		NA											9	38					0	0	0	0
SLC16A7	9194	broad.mit.edu	37	12	60169150	60169150	+	Silent	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:60169150C>G	uc001sqs.2	+	5	1373	c.1074C>G	c.(1072-1074)CTC>CTG	p.L358L	SLC16A7_uc001sqt.2_Silent_p.L358L|SLC16A7_uc001squ.2_Silent_p.L358L|SLC16A7_uc009zqi.2_Silent_p.L259L|SLC16A7_uc010ssi.1_Silent_p.L259L	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	358	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	GCAGTGTTCTCTTTGAAACTC	0.502		NA											18	123					0	0	0	0
RAB3IP	117177	broad.mit.edu	37	12	70206629	70206629	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:70206629A>C	uc001svp.2	+	9	1697	c.1250A>C	c.(1249-1251)TAT>TCT	p.Y417S	RAB3IP_uc001svm.2_Missense_Mutation_p.Y401S|RAB3IP_uc001svn.2_Intron|RAB3IP_uc001svo.2_RNA|RAB3IP_uc001svq.2_Intron|RAB3IP_uc001svr.2_Intron|RAB3IP_uc001svs.2_RNA|RAB3IP_uc001svt.2_Missense_Mutation_p.Y195S	NM_175623	NP_783322	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein isoform alpha 2	417					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			AGCAACTATTATTATATTTCT	0.328		NA											23	59					0	0	0	0
HSP90B1	7184	broad.mit.edu	37	12	104337038	104337038	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr12:104337038G>T	uc001tkb.1	+	13	1936	c.1831G>T	c.(1831-1833)GTT>TTT	p.V611F	HSP90B1_uc010swg.1_Missense_Mutation_p.V276F|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	611					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	TCGTGAAGCAGTTGAGAAAGA	0.418		NA											15	33					8.6e-14	1.03e-13	1	0
RCBTB2	1102	broad.mit.edu	37	13	49076892	49076892	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr13:49076892G>A	uc001vch.2	-	11	1456	c.1085C>T	c.(1084-1086)ACG>ATG	p.T362M	RCBTB2_uc010tgg.1_Missense_Mutation_p.T367M|RCBTB2_uc001vci.2_Missense_Mutation_p.T338M|RCBTB2_uc010tgh.1_Missense_Mutation_p.T88M|RCBTB2_uc001vcj.2_Missense_Mutation_p.T314M|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_3'UTR	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	362	RCC1 6.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		GACGGCGGGCGTGGCAAAGCA	0.612		NA											5	57					0	0	0	0
FARP1	10160	broad.mit.edu	37	13	99047720	99047720	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr13:99047720G>A	uc001vnj.2	+	13	1740	c.1404G>A	c.(1402-1404)CAG>CAA	p.Q468Q	FARP1_uc001vnh.2_Silent_p.Q468Q	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	468					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGCCCCCGCAGCCAAGCACAG	0.592		NA											31	41					0	0	0	0
ATP11A	23250	broad.mit.edu	37	13	113481200	113481200	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr13:113481200G>A	uc001vsi.3	+	12	1304	c.1216G>A	c.(1216-1218)GGA>AGA	p.G406R	ATP11A_uc001vsj.3_Missense_Mutation_p.G406R|ATP11A_uc001vsm.1_Missense_Mutation_p.G282R	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	406	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGAAGAGCTGGGACAGGTTGG	0.547		NA											5	13					0	0	0	0
OR11G2	390439	broad.mit.edu	37	14	20665703	20665703	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:20665703C>A	uc010tlb.1	+	1	209	c.209C>A	c.(208-210)ACT>AAT	p.T70N		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	70	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTGCTCTTCACTGTTGTTTAC	0.567		NA											58	48					6.21e-19	7.63e-19	1	0
NYNRIN	57523	broad.mit.edu	37	14	24886290	24886290	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:24886290G>A	uc001wpf.3	+	9	5653	c.5335G>A	c.(5335-5337)GCA>ACA	p.A1779T		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1779					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GATGAGCAGCGCAAACATTGA	0.617		NA											4	137					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64491050	64491050	+	Silent	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:64491050C>T	uc001xgm.2	+	39	5943	c.5713C>T	c.(5713-5715)CTG>TTG	p.L1905L	SYNE2_uc001xgl.2_Silent_p.L1905L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1905	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAAGAAGCATCTGCCCAAAGC	0.433		NA											29	41					0	0	0	0
PCNX	22990	broad.mit.edu	37	14	71543136	71543136	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:71543136G>T	uc001xmo.2	+	28	5783	c.5337G>T	c.(5335-5337)AAG>AAT	p.K1779N	PCNX_uc010are.1_Missense_Mutation_p.K1668N|PCNX_uc010arf.1_Missense_Mutation_p.K567N	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1779						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GAAGAGCAAAGGTAGAGTTTA	0.403		NA											8	23					0.000157383	0.000174356	1	0
TMEM63C	57156	broad.mit.edu	37	14	77715746	77715746	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:77715746C>G	uc001xtf.2	+	21	2195	c.1983C>G	c.(1981-1983)ATC>ATG	p.I661M	TMEM63C_uc010asq.1_Missense_Mutation_p.I661M	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	661	Helical; (Potential).					integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CCCAGGCCATCTTTGCGCCAC	0.562		NA											9	48					0	0	0	0
EML1	2009	broad.mit.edu	37	14	100376629	100376629	+	Silent	SNP	T	T	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr14:100376629T>G	uc001ygs.2	+	12	1359	c.1290T>G	c.(1288-1290)GGT>GGG	p.G430G	EML1_uc010tww.1_Silent_p.G418G|EML1_uc001ygq.2_Silent_p.G449G|EML1_uc001ygr.2_Silent_p.G449G	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	430	WD 4.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CTGAAAACGGTGACACCATTA	0.333		NA											12	73					0	0	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40313219	40313219	+	Silent	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr15:40313219C>T	uc001zkm.1	+	31	4343	c.4293C>T	c.(4291-4293)GAC>GAT	p.D1431D	EIF2AK4_uc010bbj.1_Silent_p.D1132D|EIF2AK4_uc001zkn.1_Silent_p.D531D|EIF2AK4_uc001zko.1_Silent_p.D312D|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1431	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCATGTACGACTGGTCACAGG	0.473		NA											5	36					0	0	0	0
CAPN3	825	broad.mit.edu	37	15	42703502	42703502	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr15:42703502G>C	uc001zpn.1	+	23	2704	c.2398G>C	c.(2398-2400)GAC>CAC	p.D800H	CAPN3_uc001zpk.1_Missense_Mutation_p.D567H|CAPN3_uc001zpl.1_Missense_Mutation_p.D707H|CAPN3_uc010udf.1_Missense_Mutation_p.D713H|CAPN3_uc010udg.1_Missense_Mutation_p.D665H|CAPN3_uc001zpo.1_Missense_Mutation_p.D794H|CAPN3_uc001zpp.1_Missense_Mutation_p.D708H|CAPN3_uc001zpq.1_Missense_Mutation_p.D288H|CAPN3_uc010bcv.1_Missense_Mutation_p.D135H|CAPN3_uc001zpr.1_Missense_Mutation_p.D135H|CAPN3_uc001zps.1_Missense_Mutation_p.D135H|CAPN3_uc001zpt.1_Missense_Mutation_p.D135H	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	800	EF-hand 4.|Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		TCATGCATTTGACAAGGATGG	0.498		NA											16	61					0	0	0	0
C15orf27	123591	broad.mit.edu	37	15	76452436	76452436	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr15:76452436T>C	uc002bbq.2	+	5	538	c.383T>C	c.(382-384)TTT>TCT	p.F128S	C15orf27_uc010bkp.2_5'UTR|C15orf27_uc002bbr.2_5'UTR	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	128						integral to membrane					0						TCCATTGCAGTTTCCAGCGCA	0.557		NA											27	123					0	0	0	0
ABCC1	4363	broad.mit.edu	37	16	16232272	16232272	+	Silent	SNP	G	G	A	rs36115566		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:16232272G>A	uc010bvi.2	+	30	4519	c.4344G>A	c.(4342-4344)ACG>ACA	p.T1448T	ABCC1_uc010bvj.2_Silent_p.T1389T|ABCC1_uc010bvk.2_Silent_p.T1392T|ABCC1_uc010bvl.2_Intron|ABCC1_uc010bvm.2_Silent_p.T1333T|ABCC1_uc002del.3_Silent_p.T1342T	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1448	ABC transporter 2.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGAGGAAGACGAAGATCCTTG	0.597		NA											7	41					0	0	0	0
CAPNS2	84290	broad.mit.edu	37	16	55601269	55601269	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:55601269G>C	uc002eid.1	+	1	686	c.601G>C	c.(601-603)GAT>CAT	p.D201H	LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706	Q96L46	CPNS2_HUMAN	calpain small subunit 2	201	EF-hand 3.					cytoplasm|plasma membrane	calcium ion binding				0						TGCTAATGAAGATGGAGATAT	0.488		NA											12	171					0	0	0	0
CNGB1	1258	broad.mit.edu	37	16	57954416	57954416	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:57954416G>T	uc002emt.2	-	19	1741	c.1676C>A	c.(1675-1677)ACA>AAA	p.T559K	CNGB1_uc010cdh.2_Missense_Mutation_p.T553K	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	559	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GGCGCTATTTGTGCTGGCCGT	0.612		NA											5	67					2.77e-08	3.25e-08	1	0
AP1G1	164	broad.mit.edu	37	16	71779057	71779057	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr16:71779057G>A	uc010cgg.2	-	19	2303	c.1989C>T	c.(1987-1989)ATC>ATT	p.I663I	AP1G1_uc002fba.2_Silent_p.I666I|AP1G1_uc002fbb.2_Silent_p.I686I|AP1G1_uc002faz.2_Silent_p.I80I	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	663					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CTGTAAGGTTGATGTCTCCCA	0.448		NA											4	58					0	0	0	0
TUSC5	286753	broad.mit.edu	37	17	1183425	1183425	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:1183425T>C	uc002fsi.1	+	1	469	c.130T>C	c.(130-132)TCC>CCC	p.S44P		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	44					response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCTGAATCTGTCCAAGACCCT	0.617		NA											27	65					0	0	0	0
POLR2A	5430	broad.mit.edu	37	17	7403976	7403976	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:7403976C>A	uc002ghf.3	+	11	1924	c.1690C>A	c.(1690-1692)CTG>ATG	p.L564M		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	564					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GATGAACCTCCTGATGTTCCT	0.542		NA											12	41					7.04e-09	8.31e-09	1	0
TP53	7157	broad.mit.edu	37	17	7578553	7578553	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:7578553T>G	uc002gim.2	-	5	571	c.377A>C	c.(376-378)TAC>TCC	p.Y126S	TP53_uc002gig.1_Missense_Mutation_p.Y126S|TP53_uc002gih.2_Missense_Mutation_p.Y126S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.Y126S|TP53_uc010cni.1_Missense_Mutation_p.Y126S|TP53_uc002gij.2_Missense_Mutation_p.Y126S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y33S|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.Y87S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	126	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> C (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> G (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y126*(9)|p.0?(7)|p.Y126N(6)|p.Y126_K132delYSPALNK(6)|p.Y126C(4)|p.Y126D(3)|p.Y126_N131delYSPALN(3)|p.Y126S(2)|p.V73fs*9(1)|p.?(1)|p.Y126Y(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)|p.Y126fs*24(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAGGGGAGTACTGTAGGAA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	14					0	0	0	0
MYO18A	399687	broad.mit.edu	37	17	27417044	27417044	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:27417044C>G	uc002hdt.1	-	37	5619	c.5461G>C	c.(5461-5463)GAA>CAA	p.E1821Q	MYO18A_uc010wbc.1_Missense_Mutation_p.E1354Q|MYO18A_uc002hds.2_Missense_Mutation_p.E1363Q|MYO18A_uc010csa.1_Missense_Mutation_p.E1784Q|MYO18A_uc002hdu.1_Missense_Mutation_p.E1821Q	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1821	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ATCTTAGCTTCCTGCCTGCTC	0.577		NA											3	23					0	0	0	0
GPR179	440435	broad.mit.edu	37	17	36483564	36483564	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:36483564G>A	uc002hpz.2	-	11	5909	c.5888C>T	c.(5887-5889)ACT>ATT	p.T1963I		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1963	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TGCTGGGGCAGTGGTCTCCCA	0.547		NA											15	32					0	0	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40839831	40839831	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:40839831C>T	uc002iay.2	+	8	1354	c.1138C>T	c.(1138-1140)CGT>TGT	p.R380C	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	380	Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity	p.R380H(1)		ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TTTCCCACGCCGTGGCCGCCT	0.637		NA											4	65					0	0	0	0
NXPH3	11248	broad.mit.edu	37	17	47656507	47656507	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:47656507G>T	uc002ipa.2	+	2	888	c.604G>T	c.(604-606)GAC>TAC	p.D202Y	NXPH3_uc010wlw.1_Missense_Mutation_p.D202Y	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	202	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					CTGCTCCCGAGACCACGCTCA	0.602		NA											20	73					8.28e-16	1e-15	1	0
MPO	4353	broad.mit.edu	37	17	56349077	56349077	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:56349077C>T	uc002ivu.1	-	11	2146	c.1969G>A	c.(1969-1971)GTG>ATG	p.V657M		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	657					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	AGTGGGCCCACGCGGCCTTTG	0.632		NA											15	27					0	0	0	0
TUBB6	84617	broad.mit.edu	37	18	12310986	12310986	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr18:12310986G>A	uc002kqw.2	+	3	256	c.211G>A	c.(211-213)GGC>AGC	p.G71S	TUBB6_uc002kqv.2_5'UTR|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Intron|TUBB6_uc002kqy.2_Missense_Mutation_p.G71S	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	71					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		CTTAGAGCCAGGCACCATGGA	0.498		NA											4	45					0	0	0	0
CELF4	56853	broad.mit.edu	37	18	34853090	34853090	+	Missense_Mutation	SNP	C	C	A	rs150441111	by1000genomes	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr18:34853090C>A	uc002lae.2	-	7	1234	c.838G>T	c.(838-840)GCG>TCG	p.A280S	CELF4_uc010dnd.1_Missense_Mutation_p.A278S|CELF4_uc002lag.2_Missense_Mutation_p.A270S|CELF4_uc002laf.2_Missense_Mutation_p.A275S|CELF4_uc002lai.2_Missense_Mutation_p.A265S|CELF4_uc002lah.1_Missense_Mutation_p.A5S|CELF4_uc002laj.1_Missense_Mutation_p.R115L	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	280	Sufficient for RNA-binding and MSE- dependent splicing activity.|Ala-rich.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						CCGCCCTGCGCGACTGATGCC	0.647		NA											42	29					2.4e-13	2.87e-13	1	0
SH3GL1	6455	broad.mit.edu	37	19	4366921	4366921	+	Splice_Site	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:4366921A>G	uc002maj.2	-	2	220	c.114_splice	c.e2+1	p.K38_splice	SH3GL1_uc002mak.2_Splice_Site_p.K38_splice|SH3GL1_uc010xig.1_Splice_Site_p.K38_splice	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1						central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		TTTCTTCCTCACCTTCTCCAT	0.597		NA	T	MLL	AL								32	229					0	0	0	0
ELAVL3	1995	broad.mit.edu	37	19	11568882	11568882	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:11568882C>T	uc002mry.1	-	5	1087	c.707G>A	c.(706-708)CGT>CAT	p.R236H	ELAVL3_uc002mrx.1_Missense_Mutation_p.R236H	NM_001420	NP_001411	Q14576	ELAV3_HUMAN	ELAV-like protein 3 isoform 1	236					cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			ovary(1)|breast(1)|skin(1)	3						TCACCGGAAACGCTGGGTCTG	0.677		NA											11	26					0	0	0	0
IL27RA	9466	broad.mit.edu	37	19	14153306	14153306	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:14153306G>C	uc002mxx.2	+	5	999	c.576G>C	c.(574-576)GAG>GAC	p.E192D		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	192	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CCCCTGTTGAGATCCAAGATT	0.567		NA									OREG0025302	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	130					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22156075	22156075	+	Silent	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:22156075G>T	uc002nqp.2	-	5	1610	c.1461C>A	c.(1459-1461)GGC>GGA	p.G487G	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAAAGCTTTGCCACATTCTT	0.353		NA											3	42					0.004672	0.0049494	1	0
ZFP14	57677	broad.mit.edu	37	19	36831737	36831737	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:36831737G>A	uc002odx.1	-	4	1084	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	ZFP14_uc010xtd.1_Nonsense_Mutation_p.Q332*|ZFP14_uc010eex.1_Nonsense_Mutation_p.Q331*	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	331	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TGAATTTTCTGATGTACTCTA	0.403		NA											31	177					0	0	0	0
ZNF790	388536	broad.mit.edu	37	19	37311007	37311007	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:37311007G>A	uc002oew.2	-	5	358	c.239C>T	c.(238-240)TCG>TTG	p.S80L	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CTGACACCTCGACTGCATGTC	0.323		NA											22	125					0	0	0	0
ZNF570	148268	broad.mit.edu	37	19	37976077	37976077	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:37976077G>A	uc002ogk.1	+	5	2082	c.1553G>A	c.(1552-1554)AGA>AAA	p.R518K	ZNF570_uc010efl.1_Missense_Mutation_p.R574K|ZNF570_uc010xtr.1_Missense_Mutation_p.R315K	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	518	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CATCACCAGAGAATTCACATT	0.269		NA											17	138					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40364231	40364231	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:40364231C>A	uc002omp.3	-	31	14419	c.14411G>T	c.(14410-14412)GGC>GTC	p.G4804V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4804						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAAGACCTCGCCCAGTGGGTA	0.657		NA											31	118					2.48e-08	2.91e-08	1	0
PSG7	5676	broad.mit.edu	37	19	43430101	43430101	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:43430101G>A	uc002ovl.3	-	6	1169	c.1067C>T	c.(1066-1068)GCG>GTG	p.A356V	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Missense_Mutation_p.A269V|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Missense_Mutation_p.A82V|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.A269V|PSG7_uc010xwl.1_Missense_Mutation_p.A234V	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	356	Ig-like C2-type 3.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTTAGAGTCCGCAAAGCAGGA	0.448		NA											4	134					0	0	0	0
GRLF1	2909	broad.mit.edu	37	19	47423337	47423337	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:47423337G>T	uc010ekv.2	+	1	1405	c.1405G>T	c.(1405-1407)GAG>TAG	p.E469*		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	469	FF 3.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		CCAGTGGCTGGAGGAATCTGT	0.378		NA											13	5					0.00010058	0.00011216	1	0
ZNF671	79891	broad.mit.edu	37	19	58238851	58238851	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:58238851G>A	uc002qpz.3	-	1	145	c.46C>T	c.(46-48)CGG>TGG	p.R16W	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Translation_Start_Site|ZNF671_uc010yhf.1_Translation_Start_Site	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGGCACTTCCGTCCCTGCAGA	0.672		NA											10	17					0	0	0	0
HADHA	3030	broad.mit.edu	37	2	26455030	26455030	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:26455030T>C	uc002rgy.2	-	6	701	c.571A>G	c.(571-573)ATG>GTG	p.M191V	HADHA_uc010yks.1_Missense_Mutation_p.M104V|HADHA_uc010ykt.1_Missense_Mutation_p.M104V	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	191					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	AGACTCACCATTTTGGGCAGC	0.398		NA											13	31					0	0	0	0
KIF5C	3800	broad.mit.edu	37	2	149850992	149850992	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:149850992A>G	uc010zbu.1	+	17	2331	c.1963A>G	c.(1963-1965)AGG>GGG	p.R655G	KIF5C_uc002tws.1_RNA|KIF5C_uc002twt.2_Missense_Mutation_p.R207G	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	655					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		ACAGAAGAGGAGGCAGCTAGA	0.493		NA											2	7					0	0	0	0
RIF1	55183	broad.mit.edu	37	2	152289598	152289598	+	Silent	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:152289598A>G	uc002txm.2	+	10	1063	c.933A>G	c.(931-933)CTA>CTG	p.L311L	RIF1_uc002txl.2_Silent_p.L311L|RIF1_uc010fnv.1_Silent_p.L275L|RIF1_uc002txn.2_Silent_p.L311L|RIF1_uc002txo.2_Silent_p.L311L|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	311					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AAGATATACTATGTAGTGCAA	0.358		NA											8	32					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152363454	152363454	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:152363454C>T	uc010fnx.2	-	135	18613	c.18422G>A	c.(18421-18423)CGT>CAT	p.R6141H	NEB_uc002txr.2_Missense_Mutation_p.R2564H|RIF1_uc002txp.2_Intron|NEB_uc010zca.1_5'Flank|NEB_uc010zcb.1_Translation_Start_Site|NEB_uc002txt.3_Missense_Mutation_p.R646H	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6141	Nebulin 168.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTTTACACGCAGTATTTC	0.318		NA											24	54					0	0	0	0
ALPPL2	251	broad.mit.edu	37	2	233274348	233274348	+	Silent	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr2:233274348C>T	uc002vss.3	+	11	1418	c.1365C>T	c.(1363-1365)GAC>GAT	p.D455D		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	455					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CAGGCGAGGACGTGGCGGTGT	0.662		NA											5	18					0	0	0	0
C20orf79	140856	broad.mit.edu	37	20	18794599	18794599	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr20:18794599T>A	uc002wrk.2	+	1	230	c.140T>A	c.(139-141)GTG>GAG	p.V47E	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	47	SCP2.						sterol binding			skin(3)	3						AGCTTCCCAGTGTTTCAGGAC	0.507		NA											22	40					0	0	0	0
NFS1	9054	broad.mit.edu	37	20	34285652	34285652	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr20:34285652T>C	uc002xdw.1	-	3	342	c.278A>G	c.(277-279)CAT>CGT	p.H93R	NFS1_uc002xdt.1_Missense_Mutation_p.H33R|NFS1_uc002xdu.1_Missense_Mutation_p.H33R|NFS1_uc002xdv.1_RNA|NFS1_uc010zvk.1_5'UTR|NFS1_uc010zvl.1_Missense_Mutation_p.H93R|NFS1_uc002xdx.2_Missense_Mutation_p.H93R|ROMO1_uc002xdy.2_5'Flank|ROMO1_uc010gfm.2_5'Flank	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	93					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GCCATAAGCATGTGTCCGGGA	0.527		NA											8	43					0	0	0	0
SLC2A10	81031	broad.mit.edu	37	20	45353864	45353864	+	Silent	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr20:45353864G>T	uc002xsl.2	+	2	286	c.189G>T	c.(187-189)CTG>CTT	p.L63L		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	63	Helical; Name=2; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCGCCTCCCTGGTTGGTGGCT	0.632		NA											15	41					6.32e-08	7.31e-08	1	0
PRPF6	24148	broad.mit.edu	37	20	62631012	62631012	+	Missense_Mutation	SNP	A	A	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr20:62631012A>C	uc002yho.2	+	8	1091	c.923A>C	c.(922-924)CAC>CCC	p.H308P	PRPF6_uc002yhp.2_Missense_Mutation_p.H308P	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	308					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					AACCCTCATCACCCGCCAGCC	0.567		NA											6	60					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	11012916	11012916	+	Splice_Site	SNP	C	C	A	rs4041777		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr21:11012916C>A	uc002yis.1	-	9		c.1704_splice	c.e9+1					P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCAAATTTTACCTAGCTTTTT	0.299		NA											10	17					0.000673444	0.000727062	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28302210	28302210	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr21:28302210C>G	uc002ymg.2	-	7	2949	c.2220G>C	c.(2218-2220)AAG>AAC	p.K740N		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	740	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						ATTACCTTTTCTTATTAAAGG	0.383		NA											5	69					0	0	0	0
LGALS1	3956	broad.mit.edu	37	22	38075659	38075659	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:38075659G>T	uc003atn.2	+	4	408	c.311G>T	c.(310-312)GGA>GTA	p.G104V		NM_002305	NP_002296	P09382	LEG1_HUMAN	galectin-1	104	Galectin.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of apoptosis	cytoplasm|extracellular space|proteinaceous extracellular matrix	galactoside binding|signal transducer activity				0	Melanoma(58;0.0574)					CTGCCAGATGGATACGAATTC	0.562		NA											18	82					2.58e-16	3.15e-16	1	0
ATXN10	25814	broad.mit.edu	37	22	46088932	46088932	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:46088932G>A	uc003bgm.1	+	3	622	c.365G>A	c.(364-366)CGA>CAA	p.R122Q	ATXN10_uc011aqt.1_Missense_Mutation_p.R58Q|ATXN10_uc003bgn.1_5'UTR	NM_013236	NP_037368	Q9UBB4	ATX10_HUMAN	ataxin 10	122					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				ovary(1)|kidney(1)	2		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		CGTGAACTGCGAGTGGAACAG	0.308		NA											9	61					0	0	0	0
PKDREJ	10343	broad.mit.edu	37	22	46653801	46653801	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:46653801G>A	uc003bhh.2	-	1	5419	c.5419C>T	c.(5419-5421)CTA>TTA	p.L1807L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1807	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TCGGCAGGTAGACACATTTTT	0.403		NA											30	254					0	0	0	0
CELSR1	9620	broad.mit.edu	37	22	46760506	46760506	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:46760506G>A	uc003bhw.1	-	33	8682	c.8682C>T	c.(8680-8682)CGC>CGT	p.R2894R		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2894	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCTGCTCCTCGCGGTGCAGCT	0.692		NA											16	64					0	0	0	0
BRD1	23774	broad.mit.edu	37	22	50216800	50216800	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr22:50216800G>A	uc003biv.2	-	1	1653	c.1166C>T	c.(1165-1167)ACG>ATG	p.T389M	BRD1_uc011arf.1_Translation_Start_Site|BRD1_uc011arg.1_Missense_Mutation_p.T389M|BRD1_uc011arh.1_Missense_Mutation_p.T389M|BRD1_uc003biu.3_Missense_Mutation_p.T389M	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	389					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCCTGGAGGCGTGTGGACATC	0.542		NA											19	180					0	0	0	0
SELK	58515	broad.mit.edu	37	3	53919910	53919910	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:53919910C>T	uc011bet.1	-	4	398	c.224G>A	c.(223-225)GGT>GAT	p.G75D		NM_021237	NP_067060	Q9Y6D0	SELK_HUMAN	selenoprotein K	75					response to oxidative stress	endoplasmic reticulum					0				BRCA - Breast invasive adenocarcinoma(193;0.000146)|KIRC - Kidney renal clear cell carcinoma(284;0.00549)|Kidney(284;0.00619)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		ATTGATTCTACCCATTCTTCG	0.408		NA											4	3					0	0	0	0
DZIP3	9666	broad.mit.edu	37	3	108344785	108344785	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:108344785G>T	uc003dxd.2	+	7	972	c.550G>T	c.(550-552)GGA>TGA	p.G184*	DZIP3_uc003dxf.1_Nonsense_Mutation_p.G184*|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Nonsense_Mutation_p.G184*	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	184					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGTTTATTTTGGACGTGGTTT	0.353		NA											21	125					8.1e-08	9.35e-08	1	0
ZDHHC23	254887	broad.mit.edu	37	3	113672564	113672564	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:113672564C>A	uc003eau.2	+	3	478	c.179C>A	c.(178-180)TCT>TAT	p.S60Y	ZDHHC23_uc003eav.2_Missense_Mutation_p.S54Y	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	60						integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						ACATGTAAATCTTTACAGCCA	0.403		NA											17	72					1.45e-14	1.75e-14	1	0
POLQ	10721	broad.mit.edu	37	3	121186390	121186390	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:121186390G>A	uc003eee.3	-	24	7072	c.6943C>T	c.(6943-6945)CGA>TGA	p.R2315*	POLQ_uc003eed.2_Nonsense_Mutation_p.R1487*	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2315					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAGGCATGTCGCATGCTAATT	0.443		NA						DNA_polymerases_(catalytic_subunits)					20	48					0	0	0	0
ADCY5	111	broad.mit.edu	37	3	123003507	123003507	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:123003507C>T	uc003egh.1	-	21	3734	c.3734G>A	c.(3733-3735)GGC>GAC	p.G1245D	ADCY5_uc003egg.1_Missense_Mutation_p.G903D	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1245	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CTCGCCTTTGCCCTTGACCTT	0.612		NA											5	288					0	0	0	0
ABTB1	80325	broad.mit.edu	37	3	127395182	127395182	+	Missense_Mutation	SNP	C	C	T	rs149260862		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:127395182C>T	uc003ejt.2	+	5	476	c.388C>T	c.(388-390)CGC>TGC	p.R130C	ABTB1_uc003ejr.2_5'UTR|ABTB1_uc003ejs.2_Missense_Mutation_p.R105C|ABTB1_uc003eju.2_5'UTR|ABTB1_uc010hsm.2_5'Flank	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	130	BTB 1.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						CCGGGTGCATCGCTGCGTCCT	0.572		NA											22	138					0	0	0	0
COL6A6	131873	broad.mit.edu	37	3	130380658	130380658	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:130380658C>T	uc010htl.2	+	34	6039	c.6008C>T	c.(6007-6009)ACT>ATT	p.T2003I	COL6A6_uc003eni.3_Missense_Mutation_p.T102I	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2003	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GAGCCGGAGACTTCTGTCACT	0.517		NA											10	38					0	0	0	0
HPS3	84343	broad.mit.edu	37	3	148880100	148880100	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:148880100G>C	uc003ewu.1	+	12	2412	c.2272G>C	c.(2272-2274)GAA>CAA	p.E758Q	HPS3_uc011bnq.1_Missense_Mutation_p.E593Q|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	758						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TGGAATTGAAGAAGCAGATTC	0.423		NA							Hermansky-Pudlak_syndrome				7	89					0	0	0	0
SHOX2	6474	broad.mit.edu	37	3	157820503	157820503	+	Silent	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:157820503C>T	uc003fbr.2	-	2	658	c.519G>A	c.(517-519)CTG>CTA	p.L173L	SHOX2_uc003fbs.2_Silent_p.L197L|SHOX2_uc010hvw.2_Silent_p.L173L	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	173	Homeobox.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GTCGCTGGCTCAGTTCCTCTC	0.607		NA											6	94					0	0	0	0
MAGEF1	64110	broad.mit.edu	37	3	184429482	184429482	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:184429482G>A	uc003fpa.2	-	1	355	c.128C>T	c.(127-129)GCC>GTC	p.A43V		NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	43										ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			CTCCCTCCCGGCGCCAAGCTC	0.751		NA											7	49					0	0	0	0
UBXN7	26043	broad.mit.edu	37	3	196089387	196089387	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr3:196089387C>T	uc003fwm.3	-	9	1081	c.1006G>A	c.(1006-1008)GAT>AAT	p.D336N	UBXN7_uc003fwn.3_Missense_Mutation_p.D188N|UBXN7_uc010iae.2_Missense_Mutation_p.D174N	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	336							protein binding			ovary(2)|pancreas(1)	3						TCTTCTTCATCAGAGCCACAA	0.443		NA											19	148					0	0	0	0
DHX15	1665	broad.mit.edu	37	4	24529592	24529592	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr4:24529592G>A	uc003gqx.2	-	14	2511	c.2343C>T	c.(2341-2343)GAC>GAT	p.D781D	DHX15_uc003gqv.2_Silent_p.D187D|DHX15_uc003gqw.2_Silent_p.D204D	NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	781					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)				CAATGATGCGGTCCAACTGTC	0.393		NA											15	23					0	0	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73156643	73156643	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr4:73156643G>T	uc003hgk.1	-	20	2897	c.2860C>A	c.(2860-2862)CGT>AGT	p.R954S		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	954	TSP type-1 3.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTCTCGGGACGGTCACCCATG	0.572		NA											23	24					1.56e-14	1.87e-14	1	0
FAT1	2195	broad.mit.edu	37	4	187539227	187539227	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr4:187539227G>T	uc003izf.2	-	10	8701	c.8513C>A	c.(8512-8514)TCA>TAA	p.S2838*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2838	Extracellular (Potential).|Cadherin 26.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTGGTTCCTGAGTCAGCATC	0.448		NA								HNSCC(5;0.00058)			26	33					1.38e-23	1.7e-23	1	0
SLC9A3	6550	broad.mit.edu	37	5	484690	484690	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:484690T>C	uc003jbe.2	-	5	989	c.877A>G	c.(877-879)ATC>GTC	p.I293V	SLC9A3_uc011clx.1_Missense_Mutation_p.I293V	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	293	Helical; Name=I/M7; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGGTAGGAGATGATGAACACG	0.642		NA											7	45					0	0	0	0
IRX1	79192	broad.mit.edu	37	5	3599777	3599777	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:3599777G>T	uc003jde.2	+	2	767	c.715G>T	c.(715-717)GAC>TAC	p.D239Y		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	239						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GCACGATGGCGACCAGAGCAA	0.662		NA											13	28					6.32e-08	7.31e-08	1	0
CDH18	1016	broad.mit.edu	37	5	19483429	19483429	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:19483429G>A	uc003jgc.2	-	11	2240	c.1863C>T	c.(1861-1863)CTC>CTT	p.L621L	CDH18_uc003jgd.2_Silent_p.L621L|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	621	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGAGAACACAGAGAAGAATAG	0.463		NA											11	21					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23510095	23510095	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:23510095A>G	uc003jgo.2	+	4	442	c.260A>G	c.(259-261)GAC>GGC	p.D87G		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	87					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CAGGTGGATGACACAGAAGAT	0.383		NA								HNSCC(3;0.000094)			7	37					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24537631	24537631	+	Silent	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:24537631G>A	uc003jgr.1	-	3	716	c.384C>T	c.(382-384)CGC>CGT	p.R128R	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	128	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TAGCTTGTGCGCGTAGAGTAT	0.413		NA								HNSCC(23;0.051)			28	59					0	0	0	0
MRPS30	10884	broad.mit.edu	37	5	44811123	44811123	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:44811123C>T	uc003joh.2	+	2	652	c.614C>T	c.(613-615)CCA>CTA	p.P205L	MRPS30_uc003joi.1_RNA	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	205					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TATAGATGCCCAGTTCATTTT	0.333		NA											4	48					0	0	0	0
PRR16	51334	broad.mit.edu	37	5	120021745	120021745	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:120021745G>T	uc003ksq.2	+	2	419	c.256G>T	c.(256-258)GGC>TGC	p.G86C	PRR16_uc003ksp.2_Missense_Mutation_p.G63C|PRR16_uc003ksr.2_Missense_Mutation_p.G16C	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	86										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		TAGCTCAAGTGGCACAACAGC	0.522		NA											5	36					1.24e-05	1.4e-05	1	0
PCDHAC1	56135	broad.mit.edu	37	5	140307589	140307589	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:140307589C>G	uc003lih.2	+	1	1288	c.1112C>G	c.(1111-1113)TCT>TGT	p.S371C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.S371C	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	371	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCTCGATTCTAATGGTAGG	0.522		NA											15	22					0	0	0	0
GRIA1	2890	broad.mit.edu	37	5	153026599	153026599	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr5:153026599C>T	uc003lva.3	+	3	697	c.332C>T	c.(331-333)CCG>CTG	p.P111L	GRIA1_uc003luy.3_Missense_Mutation_p.P111L|GRIA1_uc003luz.3_Missense_Mutation_p.P16L|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Intron|GRIA1_uc011dcx.1_Missense_Mutation_p.P42L|GRIA1_uc011dcy.1_Missense_Mutation_p.P121L|GRIA1_uc011dcz.1_Missense_Mutation_p.P121L|GRIA1_uc010jia.1_Missense_Mutation_p.P91L	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	111	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTCATTACGCCGAGCTTTCCC	0.493		NA											6	72					0	0	0	0
CAGE1	285782	broad.mit.edu	37	6	7370283	7370283	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:7370283G>A	uc003mxi.2	-	5	2075	c.1354C>T	c.(1354-1356)CAT>TAT	p.H452Y	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.H343Y|CAGE1_uc003mxk.1_Missense_Mutation_p.H343Y	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	588											0	Ovarian(93;0.0418)					AGATTAGAATGTGTCGTTTTT	0.383		NA											5	25					0	0	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056533	26056533	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:26056533C>G	uc003nfw.2	-	1	167	c.124G>C	c.(124-126)GAG>CAG	p.E42Q		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	42	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GTGATGAGCTCTGACACCGGG	0.612		NA											10	90					0	0	0	0
OR5V1	81696	broad.mit.edu	37	6	29323824	29323824	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:29323824A>G	uc011dlo.1	-	1	231	c.149T>C	c.(148-150)GTG>GCG	p.V50A		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						TGGATCAGTCACAGTCGTCAA	0.388		NA											20	125					0	0	0	0
NOTCH4	4855	broad.mit.edu	37	6	32171962	32171962	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:32171962G>T	uc003obb.2	-	19	3209	c.3070C>A	c.(3070-3072)CAC>AAC	p.H1024N	NOTCH4_uc003oba.2_5'Flank|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1024	Extracellular (Potential).|EGF-like 26.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCCAGAGAGTGGCAGGCTGCA	0.627		NA											4	25					0.00024832	0.000270677	1	0
TRERF1	55809	broad.mit.edu	37	6	42231078	42231078	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:42231078C>A	uc003osd.2	-	8	2427	c.1864G>T	c.(1864-1866)GAC>TAC	p.D622Y	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Missense_Mutation_p.D622Y	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	622	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ATCTCGTCGTCCGACATCGAG	0.667		NA											8	79					0.000274275	0.00029801	1	0
CNR1	1268	broad.mit.edu	37	6	88854382	88854382	+	Silent	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:88854382C>T	uc011dzq.1	-	2	4175	c.612G>A	c.(610-612)GTG>GTA	p.V204V	CNR1_uc010kbz.2_Silent_p.V204V|CNR1_uc011dzr.1_Silent_p.V204V|CNR1_uc011dzs.1_Silent_p.V204V|CNR1_uc003pmq.3_Silent_p.V204V|CNR1_uc011dzt.1_Silent_p.V204V|CNR1_uc010kca.2_Silent_p.V171V	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	204	Helical; Name=3; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ACAGGCTGCCCACGGAGGCAG	0.557		NA											3	30					0	0	0	0
MAN1A1	4121	broad.mit.edu	37	6	119510904	119510904	+	Missense_Mutation	SNP	C	C	T	rs117089274	byFrequency	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:119510904C>T	uc003pym.1	-	10	1913	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K		NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	491	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	p.E491K(1)		ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		GCCATGCCTTCGGGAGCTGCA	0.522		NA											11	85					0	0	0	0
C6orf97	80129	broad.mit.edu	37	6	151859254	151859254	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:151859254C>G	uc003qol.2	+	3	350	c.261C>G	c.(259-261)TAC>TAG	p.Y87*		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	87	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		TGGAGAGCTACAAGGAAAACA	0.388		NA											7	46					0	0	0	0
C6orf97	80129	broad.mit.edu	37	6	151936746	151936746	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr6:151936746G>T	uc003qol.2	+	10	1968	c.1879G>T	c.(1879-1881)GAA>TAA	p.E627*		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	627	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AAACATGATAGAAGTGGTAAC	0.403		NA											37	82					2.87e-16	3.49e-16	1	0
GPNMB	10457	broad.mit.edu	37	7	23286502	23286502	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:23286502G>A	uc003swc.2	+	1	187	c.26G>A	c.(25-27)GGA>GAA	p.G9E	GPNMB_uc003swa.2_Missense_Mutation_p.G9E|GPNMB_uc003swb.2_Missense_Mutation_p.G9E|GPNMB_uc011jyy.1_Missense_Mutation_p.G9E|GPNMB_uc011jyz.1_Missense_Mutation_p.G9E	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	9					negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			TATTTCCTGGGATTTCTGCTC	0.478		NA											28	51					0	0	0	0
HOXA7	3204	broad.mit.edu	37	7	27194647	27194647	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:27194647C>T	uc003sys.2	-	2	706	c.574G>A	c.(574-576)GAA>AAA	p.E192K	HOXA6_uc003syq.1_5'Flank|uc003syr.1_3'UTR	NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	192					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0						GTCGGACCTTCGTCCTTATGC	0.537		NA											11	120					0	0	0	0
RNF148	378925	broad.mit.edu	37	7	122341901	122341901	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:122341901T>C	uc003vkk.1	-	1	1121	c.904A>G	c.(904-906)ATC>GTC	p.I302V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF133_uc003vkj.1_5'Flank|RNF148_uc010lkr.1_3'UTR	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	302						integral to membrane	zinc ion binding				0						GTTTTCAGGATGTCACACTTG	0.358		NA											7	106					0	0	0	0
FLNC	2318	broad.mit.edu	37	7	128489488	128489488	+	Silent	SNP	G	G	A	rs57797061	by1000genomes	TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:128489488G>A	uc003vnz.3	+	30	5264	c.5055G>A	c.(5053-5055)CCG>CCA	p.P1685P	FLNC_uc003voa.3_Silent_p.P1685P	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1685	Filamin 15.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TGTCCACGCCGGATGGGGCAG	0.607		NA											3	53					0	0	0	0
COPS5	10987	broad.mit.edu	37	8	67958147	67958147	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:67958147C>G	uc003xxe.2	-	7	1151	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	COPS5_uc003xxd.2_Missense_Mutation_p.E210Q|COPS5_uc003xxf.2_Missense_Mutation_p.E319Q|COPS5_uc010lyu.1_RNA	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	274					cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TCTGACTGCTCTAACTTTTCA	0.438		NA											6	89					0	0	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744677	70744677	+	Missense_Mutation	SNP	G	G	C	rs146746403		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:70744677G>C	uc003xyl.2	-	2	939	c.232C>G	c.(232-234)CCG>GCG	p.P78A	SLCO5A1_uc010lzb.2_Missense_Mutation_p.P78A|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.P78A|SLCO5A1_uc010lzc.2_Missense_Mutation_p.P78A	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	78	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGGGCCAACGGGTTCGGGCCT	0.647		NA									OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	43					0	0	0	0
CTHRC1	115908	broad.mit.edu	37	8	104394752	104394752	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:104394752C>G	uc003ylk.2	+	4	755	c.656C>G	c.(655-657)TCA>TGA	p.S219*		NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	219						collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			GGTACTTGTTCAGATTACCCA	0.373		NA											13	158					0	0	0	0
RECQL4	9401	broad.mit.edu	37	8	145740836	145740836	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr8:145740836C>T	uc003zdj.2	-	7	1296	c.1264G>A	c.(1264-1266)GAG>AAG	p.E422K	LRRC14_uc003zdk.1_5'Flank|LRRC14_uc003zdl.1_5'Flank	NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	422					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GTGTCTTCCTCACTTGCTGGG	0.612		NA	N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				7	85					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971096	21971096	+	Nonsense_Mutation	SNP	C	C	A	rs121913384		TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:21971096C>A	uc003zpk.2	-	2	474	c.262G>T	c.(262-264)GAG>TAG	p.E88*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.G143V	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	88	ANK 3.		E -> D (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E88*(13)|p.E88E(6)|p.E88K(3)|p.H83fs*2(2)|p.E88D(2)|p.E88A(1)|p.E88G(1)|p.D84_F90del(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.E88V(1)|p.E87K(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		AGGAAGCCCTCCCGGGCAGCG	0.756	E88*(CAL33_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	11					8.13e-05	9.09e-05	1	0
PRUNE2	158471	broad.mit.edu	37	9	79324742	79324742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:79324742C>T	uc010mpk.2	-	8	2572	c.2448G>A	c.(2446-2448)TGG>TGA	p.W816*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	816					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GGTGCAAATTCCAGGTATTTT	0.468		NA											8	29					0	0	0	0
C9orf79	286234	broad.mit.edu	37	9	90502130	90502130	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:90502130A>G	uc004app.3	+	4	2763	c.2728A>G	c.(2728-2730)AGC>GGC	p.S910G	C9orf79_uc004apo.1_Missense_Mutation_p.S722G	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	910						integral to membrane				ovary(3)	3						CAGAACAACAAGCAAGTCAGT	0.602		NA											4	49					0	0	0	0
PTCH1	5727	broad.mit.edu	37	9	98239831	98239831	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr9:98239831G>C	uc004avk.3	-	10	1689	c.1501C>G	c.(1501-1503)CAG>GAG	p.Q501E	PTCH1_uc010mro.2_Missense_Mutation_p.Q350E|PTCH1_uc010mrp.2_Missense_Mutation_p.Q350E|PTCH1_uc010mrq.2_Missense_Mutation_p.Q350E|PTCH1_uc004avl.3_Missense_Mutation_p.Q350E|PTCH1_uc010mrr.2_Missense_Mutation_p.Q435E|PTCH1_uc004avm.3_Missense_Mutation_p.Q500E|PTCH1_uc010mrs.1_Intron	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	501	Extracellular (Potential).|SSD.				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TTTAGTACCTGAGTTGTTGCA	0.582		NA							Basal_Cell_Nevus_syndrome				6	35					0	0	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069195	6069195	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:6069195G>T	uc010ndh.2	-	2	814	c.313C>A	c.(313-315)CAG>AAG	p.Q105K	NLGN4X_uc004crp.2_Missense_Mutation_p.Q105K|NLGN4X_uc004crq.2_Missense_Mutation_p.Q105K|NLGN4X_uc010ndi.2_Missense_Mutation_p.Q105K|NLGN4X_uc004crr.2_Missense_Mutation_p.Q105K|NLGN4X_uc010ndj.2_Missense_Mutation_p.Q105K	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	105	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GCAGCAAACTGAGTAGTATTT	0.557		NA											11	31					2.81e-09	3.33e-09	1	0
GRPR	2925	broad.mit.edu	37	X	16142365	16142365	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:16142365G>A	uc004cxj.2	+	1	942	c.289G>A	c.(289-291)GAT>AAT	p.D97N		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	97	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					TGCTCCAGTGGATGCCAGCAG	0.502		NA									OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	27					0	0	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104993010	104993010	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:104993010T>C	uc004elz.1	+	9	1862	c.1106T>C	c.(1105-1107)GTA>GCA	p.V369A		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	369	Helical; (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						CTCCTCCTTGTACTGCTGGTG	0.413		NA											6	44					0	0	0	0
GPR101	83550	broad.mit.edu	37	X	136113430	136113430	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:136113430T>C	uc011mwh.1	-	1	404	c.404A>G	c.(403-405)CAC>CGC	p.H135R		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	135	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GGAGAGAGGGTGGATGATGGA	0.592		NA											7	12					0	0	0	0
SLITRK2	84631	broad.mit.edu	37	X	144906200	144906200	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chrX:144906200G>C	uc004fcd.2	+	5	3247	c.2257G>C	c.(2257-2259)GAG>CAG	p.E753Q	SLITRK2_uc010nsp.2_Missense_Mutation_p.E753Q|SLITRK2_uc010nso.2_Missense_Mutation_p.E753Q|SLITRK2_uc011mwq.1_Missense_Mutation_p.E753Q|SLITRK2_uc011mwr.1_Missense_Mutation_p.E753Q|SLITRK2_uc011mws.1_Missense_Mutation_p.E753Q|SLITRK2_uc004fcg.2_Missense_Mutation_p.E753Q|SLITRK2_uc011mwt.1_Missense_Mutation_p.E753Q|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	753	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAGAGCCTGAGCTGCTGTA	0.488		NA											13	98					0	0	0	0
TEX19	400629	broad.mit.edu	37	17	80320301	80320302	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr17:80320301_80320302insG	uc002keq.2	+	2	584_585	c.275_276insG	c.(274-276)CAGfs	p.Q92fs		NM_207459	NP_997342	Q8NA77	TEX19_HUMAN	testis expressed 19	92						nucleus					0						CAGCCTGTGCAGGGGGGCTCTG	0.649		NA											12	81	---	---	---	---	NA	NA	NA	NA
PPP4R1	9989	broad.mit.edu	37	18	9559423	9559424	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr18:9559423_9559424insT	uc002koe.1	-	14	2139_2140	c.2021_2022insA	c.(2020-2022)GACfs	p.D674fs	PPP4R1_uc002kof.2_Frame_Shift_Ins_p.D91fs|PPP4R1_uc010wzo.1_Frame_Shift_Ins_p.D520fs|PPP4R1_uc002kod.1_Frame_Shift_Ins_p.D657fs|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	674					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						TCACCTGCATGTCTGAGGCCAG	0.46		NA											146	161	---	---	---	---	NA	NA	NA	NA
UBA52	7311	broad.mit.edu	37	19	18685943	18685945	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:18685943_18685945delAAG	uc002njr.2	+	5	484_486	c.370_372delAAG	c.(370-372)AAGdel	p.K126del	UBA52_uc002njs.2_In_Frame_Del_p.K126del|UBA52_uc002njt.2_In_Frame_Del_p.K126del	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor	126					activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						CCTGCGTCCCAAGAAGAAGGTCA	0.567		NA											9	58	---	---	---	---	NA	NA	NA	NA
ACPT	93650	broad.mit.edu	37	19	51298400	51298401	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr19:51298400_51298401delGG	uc002pta.1	+	11	1266_1267	c.1266_1267delGG	c.(1264-1269)TTGGGGfs	p.L422fs		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	422_423	Cytoplasmic (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGCGGGCCTTGGGGGGCCCCGT	0.649		NA											2	4	---	---	---	---	NA	NA	NA	NA
MORC3	23515	broad.mit.edu	37	21	37741775	37741775	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr21:37741775delA	uc002yvi.2	+	15	2185	c.2109delA	c.(2107-2109)CTAfs	p.L703fs		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	703	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GAAACCAGCTACTCCTTGTCA	0.388		NA											35	34	---	---	---	---	NA	NA	NA	NA
SRRT	51593	broad.mit.edu	37	7	100473251	100473274	+	In_Frame_Del	DEL	GACAAGTTCAGAAGAGAGCGCAGC	GACAAGTTCAGAAGAGAGCGCAGC	-			TCGA-CN-6012-01A-11D-1683-08	TCGA-CN-6012-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c5d99faa-ef68-4f08-af97-d722bcc383f5	ecf5b1b2-34a4-45f0-8e1a-abfff67dec3b	g.chr7:100473251_100473274delGACAAGTTCAGAAGAGAGCGCAGC	uc003uwy.2	+	3	308_331	c.40_63delGACAAGTTCAGAAGAGAGCGCAGC	c.(40-63)GACAAGTTCAGAAGAGAGCGCAGCdel	p.DKFRRERS14del	SRRT_uc010lhl.1_In_Frame_Del_p.DKFRRERS14del|SRRT_uc003uxa.2_In_Frame_Del_p.DKFRRERS14del|SRRT_uc003uwz.2_In_Frame_Del_p.DKFRRERS14del	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	14_21	Arg-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						AAGGCGCAGGGACAAGTTCAGAAGAGAGCGCAGCGACTACGACC	0.58		NA											32	93	---	---	---	---	NA	NA	NA	NA