Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NADK	65220	broad.mit.edu	37	1	1686106	1686106	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:1686106C>T	uc009vkw.2	-	8	841	c.720G>A	c.(718-720)CTG>CTA	p.L240L	NADK_uc001aic.2_Silent_p.L240L|NADK_uc001aid.3_Silent_p.L240L|NADK_uc001aie.2_Silent_p.L385L|NADK_uc010nyv.1_Silent_p.L208L|NADK_uc009vkx.1_Silent_p.L118L	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	240					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CCCTGACCTTCAGCCGACTCC	0.647		NA											60	22					0	0	0	0
SPEN	23013	broad.mit.edu	37	1	16258889	16258889	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:16258889A>T	uc001axk.1	+	11	6358	c.6154A>T	c.(6154-6156)AAA>TAA	p.K2052*	SPEN_uc010obp.1_Nonsense_Mutation_p.K2011*	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2052					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGGCACAGACAAAAACCCCCC	0.502		NA											28	10					0	0	0	0
NBPF1	55672	broad.mit.edu	37	1	16893786	16893786	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:16893786T>A	uc009vos.1	-	26	3840	c.2952A>T	c.(2950-2952)AGA>AGT	p.R984S	NBPF1_uc009vot.1_Missense_Mutation_p.R367S|NBPF1_uc001ayz.1_Missense_Mutation_p.R367S|NBPF1_uc010oce.1_Missense_Mutation_p.R638S	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	984	NBPF 6.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TTGAATAACATCTATCCAGTG	0.493		NA											66	657					0	0	0	0
ZNF683	257101	broad.mit.edu	37	1	26691127	26691127	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:26691127T>C	uc001bmg.1	-	4	1028	c.910A>G	c.(910-912)ACA>GCA	p.T304A	ZNF683_uc001bmh.1_Missense_Mutation_p.T304A|ZNF683_uc009vsj.1_Missense_Mutation_p.T304A	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GCGGTGCCTGTCTGGGAACTC	0.577		NA											3	130					0	0	0	0
MANEAL	149175	broad.mit.edu	37	1	38265848	38265848	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:38265848C>G	uc001cby.2	+	4	1428	c.1347C>G	c.(1345-1347)ATC>ATG	p.I449M	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Missense_Mutation_p.I227M	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	449	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGCACTTCATCAAAGAGAAGG	0.582		NA											44	18					0	0	0	0
MSH4	4438	broad.mit.edu	37	1	76276476	76276476	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:76276476T>C	uc001dhd.1	+	4	724	c.683T>C	c.(682-684)ATC>ACC	p.I228T		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	228					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TTCACTCTGATCACAGAAAAT	0.264		NA						MMR					27	11					0	0	0	0
BCL10	8915	broad.mit.edu	37	1	85733454	85733454	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:85733454G>A	uc001dkz.2	-	4	1263	c.558C>T	c.(556-558)ATC>ATT	p.I186I		NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	186					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		TTGAAGAGAAGATGGTATTTT	0.458		NA	T	IGH@	MALT 								19	10					0	0	0	0
BRDT	676	broad.mit.edu	37	1	92446620	92446620	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:92446620C>A	uc001dok.3	+	10	1984	c.1635C>A	c.(1633-1635)AGC>AGA	p.S545R	BRDT_uc001dol.3_Missense_Mutation_p.S545R|BRDT_uc010osz.1_Missense_Mutation_p.S549R|BRDT_uc009wdf.2_Missense_Mutation_p.S472R|BRDT_uc010ota.1_Missense_Mutation_p.S499R|BRDT_uc010otb.1_Missense_Mutation_p.S499R|BRDT_uc001dom.3_Missense_Mutation_p.S545R	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		CTTCTCTGAGCAATTCCAATC	0.368		NA											29	11					1.51e-07	5.59e-07	1	0
SLC19A2	10560	broad.mit.edu	37	1	169446399	169446399	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:169446399C>A	uc001gge.3	-	2	1005	c.801G>T	c.(799-801)GAG>GAT	p.E267D	SLC19A2_uc001ggf.3_Intron	NM_006996	NP_008927	O60779	S19A2_HUMAN	solute carrier family 19, member 2	267	Cytoplasmic (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)					TTACCGGTTCCTCCACGGGAG	0.478		NA											56	79					5.73e-24	2.24e-23	1	0
F5	2153	broad.mit.edu	37	1	169511140	169511140	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:169511140C>T	uc001ggg.1	-	13	3333	c.3188G>A	c.(3187-3189)AGA>AAA	p.R1063K		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1063	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATGCTTAAGTCTTCTTTCTGA	0.423		NA											66	130					0	0	0	0
LAD1	3898	broad.mit.edu	37	1	201356297	201356297	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:201356297G>A	uc001gwm.2	-	3	427	c.192C>T	c.(190-192)AGC>AGT	p.S64S	LAD1_uc009wzu.1_Silent_p.S86S	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	64						basement membrane	structural molecule activity				0						CTTCTTCCACGCTCGGTAGTC	0.557		NA											21	47					0	0	0	0
GNPAT	8443	broad.mit.edu	37	1	231406686	231406686	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:231406686A>G	uc001hup.3	+	10	1668	c.1462A>G	c.(1462-1464)ATT>GTT	p.I488V	GNPAT_uc009xfp.2_Missense_Mutation_p.I427V	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	488					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				GCTGCTCAACATTTTTGTGCG	0.453		NA											68	92					0	0	0	0
ZNF695	57116	broad.mit.edu	37	1	247150864	247150864	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:247150864T>C	uc009xgu.2	-	4	1098	c.953A>G	c.(952-954)CAT>CGT	p.H318R	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	318	C2H2-type 6.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTCTCTACTATGAATTCTCTT	0.348		NA											9	13					0	0	0	0
MYO3A	53904	broad.mit.edu	37	10	26377179	26377179	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:26377179G>T	uc001isn.2	+	15	1767	c.1407G>T	c.(1405-1407)TTG>TTT	p.L469F	MYO3A_uc009xko.1_Missense_Mutation_p.L469F|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.L469F	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	469	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TGAACAATTTGGTAGAAGCCT	0.294		NA											15	21					3.46e-05	0.000124777	1	0
CCAR1	55749	broad.mit.edu	37	10	70514524	70514524	+	Silent	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:70514524T>A	uc001joo.2	+	12	1517	c.1398T>A	c.(1396-1398)GCT>GCA	p.A466A	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Silent_p.A271A|CCAR1_uc009xpx.1_Silent_p.A440A|CCAR1_uc001jon.1_Silent_p.A412A|CCAR1_uc010qiz.1_Silent_p.A451A|CCAR1_uc010qja.1_Silent_p.A451A|CCAR1_uc010qjb.1_RNA|SNORD98_uc001jop.1_5'Flank	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	466					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						AGTCATGTGCTCTTGCTGAGG	0.358		NA											32	44					0	0	0	0
DDX21	9188	broad.mit.edu	37	10	70728814	70728814	+	Silent	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:70728814A>G	uc001jov.1	+	7	1263	c.1173A>G	c.(1171-1173)AAA>AAG	p.K391K	DDX21_uc001jow.1_Silent_p.K323K	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	391	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						AATACATGAAATCTACATATG	0.363		NA											34	48					0	0	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105362339	105362339	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:105362339T>A	uc001kxj.1	-	14	2692	c.2552A>T	c.(2551-2553)TAT>TTT	p.Y851F	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.Y686F|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.Y728F|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.Y686F|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.Y794F	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	879	SH3 4.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		AAACCTCACATACCACCACCC	0.612		NA											29	34					0	0	0	0
GRK5	2869	broad.mit.edu	37	10	121207759	121207759	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:121207759C>T	uc001led.2	+	13	1624	c.1391C>T	c.(1390-1392)CCC>CTC	p.P464L	GRK5_uc009xzh.2_Missense_Mutation_p.P329L	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	464	AGC-kinase C-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		TTGGACCCTCCCTTCGTTCCA	0.627		NA											70	100					0	0	0	0
BAG3	9531	broad.mit.edu	37	10	121411327	121411327	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr10:121411327C>T	uc001lem.2	+	1	446	c.140C>T	c.(139-141)ACT>ATT	p.T47I	BAG3_uc001lel.2_Missense_Mutation_p.T47I	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	47	WW 1.				anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AGCCGCACCACTACGTGGAAC	0.726		NA											24	17					0	0	0	0
CDHR5	53841	broad.mit.edu	37	11	621106	621106	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:621106C>T	uc001lqj.2	-	7	868	c.763G>A	c.(763-765)GGG>AGG	p.G255R	CDHR5_uc001lqk.2_Missense_Mutation_p.G255R|CDHR5_uc009ycc.2_Missense_Mutation_p.G89R|CDHR5_uc009ycd.2_Missense_Mutation_p.G255R|CDHR5_uc001lql.2_Missense_Mutation_p.G255R|CDHR5_uc001lqm.2_Missense_Mutation_p.G89R|CDHR5_uc009yce.1_Missense_Mutation_p.G224R	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	255	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GGGACAGCCCCGTGGTACTGA	0.652		NA											24	29					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1261156	1261156	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:1261156G>A	uc009ycr.1	+	44	5916	c.5790G>A	c.(5788-5790)GCG>GCA	p.A1930A	MUC5B_uc001ltb.2_Silent_p.A1240A|MUC5B_uc001lta.2_Silent_p.A905A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1237	Cys-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCCCACAGCGGAGAACTGCC	0.657		NA											6	20					0	0	0	0
OR52A5	390054	broad.mit.edu	37	11	5153166	5153166	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:5153166G>A	uc010qyx.1	-	1	707	c.707C>T	c.(706-708)GCA>GTA	p.A236V		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CTTGAATCGTGCCTCCTTCTG	0.408		NA											14	35					0	0	0	0
OR4C15	81309	broad.mit.edu	37	11	55322553	55322553	+	Silent	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:55322553G>T	uc010rig.1	+	1	771	c.771G>T	c.(769-771)GGG>GGT	p.G257G		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCAACAGTGGGTTTATCTGCA	0.463		NA								HNSCC(20;0.049)			15	22					3.27e-08	1.22e-07	1	0
OR4C6	219432	broad.mit.edu	37	11	55433051	55433051	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:55433051C>T	uc001nht.3	+	3	674	c.409C>T	c.(409-411)CGG>TGG	p.R137W	OR4C6_uc010rik.1_Missense_Mutation_p.R137W	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CATGAGTCCACGGGTGTGCTG	0.512		NA											48	18					0	0	0	0
KAT5	10524	broad.mit.edu	37	11	65482325	65482325	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:65482325G>A	uc001ofi.2	+	9	1124	c.874G>A	c.(874-876)GAG>AAG	p.E292K	KAT5_uc001ofj.2_Missense_Mutation_p.E240K|KAT5_uc001ofk.2_Missense_Mutation_p.E325K|KAT5_uc010roo.1_Missense_Mutation_p.E273K|KAT5_uc001ofl.2_Missense_Mutation_p.E81K	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	292					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						TCCAGGCAATGAGATTTACCG	0.537		NA											36	99					0	0	0	0
ODZ4	26011	broad.mit.edu	37	11	78516412	78516412	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:78516412C>A	uc001ozl.3	-	15	2567	c.2104G>T	c.(2104-2106)GGC>TGC	p.G702C		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	702	Extracellular (Potential).|EGF-like 5.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GTTCCGTGGCCTGAACACTGG	0.607		NA											6	3					8.13e-05	0.000290292	1	0
NOX4	50507	broad.mit.edu	37	11	89070672	89070672	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:89070672C>T	uc001pct.2	-	16	1697	c.1458G>A	c.(1456-1458)GAG>GAA	p.E486E	NOX4_uc009yvr.2_Silent_p.E461E|NOX4_uc001pcu.2_Silent_p.E412E|NOX4_uc001pcw.2_Silent_p.E179E|NOX4_uc001pcx.2_Silent_p.E139E|NOX4_uc001pcv.2_Silent_p.E446E|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Silent_p.E299E|NOX4_uc009yvp.2_Silent_p.E250E|NOX4_uc010rtv.1_Silent_p.E422E|NOX4_uc009yvq.2_Silent_p.E462E	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	486	Cytoplasmic (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CAGGTCTGTTCTCTTGCCAAA	0.368		NA											5	22					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	100169994	100169994	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:100169994C>T	uc001pga.2	+	20	2825	c.2486C>T	c.(2485-2487)TCT>TTT	p.S829F	CNTN5_uc001pfz.2_Missense_Mutation_p.S829F|CNTN5_uc001pgb.2_Missense_Mutation_p.S755F|CNTN5_uc010ruk.1_Missense_Mutation_p.S100F	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	829	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTGACATCCTCTGAAGCTTCC	0.433		NA											46	11					0	0	0	0
EXPH5	23086	broad.mit.edu	37	11	108380450	108380450	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:108380450G>A	uc001pkk.2	-	6	5895	c.5784C>T	c.(5782-5784)AAC>AAT	p.N1928N	EXPH5_uc010rvy.1_Silent_p.N1740N|EXPH5_uc010rvz.1_Silent_p.N1772N|EXPH5_uc010rwa.1_Silent_p.N1852N	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1928					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GGTTGGGAGGGTTCCTCAAAT	0.413		NA											50	13					0	0	0	0
UBE4A	9354	broad.mit.edu	37	11	118263519	118263519	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:118263519C>T	uc001psw.2	+	19	3112	c.2983C>T	c.(2983-2985)CCC>TCC	p.P995S	UBE4A_uc001psv.2_Missense_Mutation_p.P1002S	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	995	U-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GTTCCTGGATCCCATTATGAG	0.473		NA											131	26					0	0	0	0
TECTA	7007	broad.mit.edu	37	11	121058640	121058640	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:121058640C>T	uc010rzo.1	+	20	6099	c.6099C>T	c.(6097-6099)TAC>TAT	p.Y2033Y		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	2033	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAGGGGATTACGACGAAGTTC	0.453		NA											72	15					0	0	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709211	128709211	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr11:128709211C>G	uc001qeo.1	-	2	1036	c.985G>C	c.(985-987)GTA>CTA	p.V329L	KCNJ1_uc001qep.1_Missense_Mutation_p.V310L|KCNJ1_uc001qeq.1_Missense_Mutation_p.V310L|KCNJ1_uc001qer.1_Missense_Mutation_p.V310L|KCNJ1_uc001qes.1_Missense_Mutation_p.V310L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	329	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	GTCTTGGATACTATGGGAGCA	0.493		NA											44	37					0	0	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6438514	6438514	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:6438514G>A	uc001qnu.2	-	10	1613	c.1332C>T	c.(1330-1332)CCC>CCT	p.P444P	TNFRSF1A_uc001qnt.2_Silent_p.P336P|TNFRSF1A_uc010sey.1_Silent_p.P212P|TNFRSF1A_uc010sez.1_Silent_p.P336P|TNFRSF1A_uc009zek.2_Silent_p.P401P	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	444	Cytoplasmic (Potential).			GPAA -> APP (in Ref. 5; AAA36756).	apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3						ggagggcggcggggccgcAAA	0.567		NA											6	18					0	0	0	0
LRP6	4040	broad.mit.edu	37	12	12278294	12278294	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:12278294C>G	uc001rah.3	-	21	4527	c.4385G>C	c.(4384-4386)CGA>CCA	p.R1462P	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.R1417P	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1462	Cytoplasmic (Potential).				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AACATGGGCTCGGTCATAGGG	0.443		NA											18	22					0	0	0	0
BCAT1	586	broad.mit.edu	37	12	25047338	25047338	+	Silent	SNP	T	T	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:25047338T>G	uc001rgd.3	-	3	592	c.150A>C	c.(148-150)GGA>GGC	p.G50G	BCAT1_uc001rgc.2_Silent_p.G49G|BCAT1_uc010six.1_Silent_p.G62G|BCAT1_uc010siy.1_Silent_p.G50G|BCAT1_uc001rge.3_Silent_p.G26G	NM_005504	NP_005495	P54687	BCAT1_HUMAN	branched chain aminotransferase 1, cytosolic	50					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	TGAACACAGTTCCAAAAACCA	0.438		NA											5	15					0	0	0	0
ITPR2	3709	broad.mit.edu	37	12	26781079	26781079	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:26781079C>T	uc001rhg.2	-	23	3368	c.2951G>A	c.(2950-2952)AGA>AAA	p.R984K		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	984	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	p.R984K(1)		kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					ATAATCCAGTCTGACACTCAG	0.353		NA											61	119					0	0	0	0
C12orf71	728858	broad.mit.edu	37	12	27234247	27234247	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:27234247T>C	uc001rhq.2	-	2	709	c.670A>G	c.(670-672)ATC>GTC	p.I224V		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	224											0						GAGGGGAGGATACGCTGCCTC	0.552		NA											53	73					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49420108	49420108	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:49420108C>T	uc001rta.3	-	48	15641	c.15641G>A	c.(15640-15642)CGC>CAC	p.R5214H		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5214	FYR N-terminal.		R -> H (in KABS).		chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAATAGATGCGCGTGGCCTC	0.577		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			23	30					0	0	0	0
KRT78	196374	broad.mit.edu	37	12	53237950	53237950	+	Missense_Mutation	SNP	G	G	A	rs145166082		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:53237950G>A	uc001sbc.1	-	6	1038	c.974C>T	c.(973-975)ACG>ATG	p.T325M		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	325	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						CTGGACTTTCGTTTCCTGCAT	0.527		NA											81	96					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57604642	57604642	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:57604642T>C	uc001snd.2	+	83	13362	c.12896T>C	c.(12895-12897)CTG>CCG	p.L4299P		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4299	Extracellular (Potential).|EGF-like 19.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCGGCTTCCTGGGCGACCGC	0.647		NA											3	36					0	0	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58021951	58021951	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:58021951C>T	uc001spg.1	-	9	1529	c.1097G>A	c.(1096-1098)CGG>CAG	p.R366Q	B4GALNT1_uc010sru.1_Missense_Mutation_p.R311Q	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	366	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CCTCTCCAGCCGCGTCCGCGC	0.652		NA											24	39					0	0	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72038823	72038823	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:72038823T>A	uc001swo.2	-	4	1472	c.1113A>T	c.(1111-1113)GAA>GAT	p.E371D		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	371	Potential.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GAAGCTGTAATTCAGATAGTT	0.338		NA											16	22					0	0	0	0
DDX55	57696	broad.mit.edu	37	12	124104018	124104018	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:124104018T>C	uc001ufi.2	+	13	1397	c.1373T>C	c.(1372-1374)CTG>CCG	p.L458P	DDX55_uc001ufh.2_Nonstop_Mutation_p.*306R|DDX55_uc001ufk.2_Missense_Mutation_p.L311P|DDX55_uc001ufl.2_Missense_Mutation_p.L65P	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	458							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TTTGCCCTGCTGAGGATGCCC	0.438		NA											49	79					0	0	0	0
GOLGA3	2802	broad.mit.edu	37	12	133384625	133384625	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:133384625T>C	uc001ukz.1	-	5	1589	c.1030A>G	c.(1030-1032)ATG>GTG	p.M344V	GOLGA3_uc001ula.1_Missense_Mutation_p.M344V|GOLGA3_uc001ulb.2_Missense_Mutation_p.M344V	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	344					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCGTTGACCATATAGGGGGTG	0.612		NA											33	38					0	0	0	0
SACS	26278	broad.mit.edu	37	13	23905802	23905802	+	Silent	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:23905802T>C	uc001uon.2	-	10	12802	c.12213A>G	c.(12211-12213)GAA>GAG	p.E4071E	SACS_uc001uoo.2_Silent_p.E3924E|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4071					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGCAAAAGTTTCACTTCTGC	0.363		NA											19	33					0	0	0	0
CDK8	1024	broad.mit.edu	37	13	26967609	26967609	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:26967609A>G	uc001uqr.1	+	7	778	c.752A>G	c.(751-753)CAG>CGG	p.Q251R	CDK8_uc001uqs.1_Missense_Mutation_p.Q251R|CDK8_uc001uqt.1_Missense_Mutation_p.Q78R	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	251	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CACCATGACCAGCTGGACAGA	0.363		NA											73	109					0	0	0	0
FLT1	2321	broad.mit.edu	37	13	28913349	28913349	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:28913349T>C	uc001usb.3	-	17	2729	c.2444A>G	c.(2443-2445)TAT>TGT	p.Y815C	FLT1_uc001usa.3_Missense_Mutation_p.Y33C	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	815	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCTGGCATCATAAGGGAGCCG	0.348		NA											21	38					0	0	0	0
FRY	10129	broad.mit.edu	37	13	32798394	32798394	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:32798394G>A	uc001utx.2	+	37	5284	c.4788G>A	c.(4786-4788)ACG>ACA	p.T1596T	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTCCCTACACGGGCTGGTTGC	0.498		NA											42	48					0	0	0	0
ZC3H13	23091	broad.mit.edu	37	13	46577305	46577305	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:46577305C>G	uc010tfw.1	-	7	919	c.913G>C	c.(913-915)GAA>CAA	p.E305Q	ZC3H13_uc001vas.1_Missense_Mutation_p.E305Q|ZC3H13_uc001vat.1_Missense_Mutation_p.E305Q	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	305							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CTTTGTCGTTCAAAATCTCGT	0.313		NA											7	154					0	0	0	0
GPC5	2262	broad.mit.edu	37	13	92408604	92408604	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:92408604C>T	uc010tif.1	+	5	1576	c.1210C>T	c.(1210-1212)CAG>TAG	p.Q404*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	404						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TCTAGCTGATCAGCTTTGTGC	0.373		NA											27	62					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110831315	110831315	+	Missense_Mutation	SNP	C	C	T	rs113994110		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr13:110831315C>T	uc001vqw.3	-	31	2535	c.2413G>A	c.(2413-2415)GGA>AGA	p.G805R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	805	Triple-helical region.		G -> R (in BSVDH).		angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCCTAGCTCCAGGGGGGCCT	0.547		NA											6	16					0	0	0	0
NIN	51199	broad.mit.edu	37	14	51227017	51227017	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr14:51227017T>A	uc001wym.2	-	17	2148	c.1957A>T	c.(1957-1959)AAC>TAC	p.N653Y	NIN_uc001wyi.2_Missense_Mutation_p.N653Y|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.N653Y|NIN_uc010tqp.1_Missense_Mutation_p.N659Y|NIN_uc001wyo.2_Missense_Mutation_p.N653Y	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	653	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCTTCATGTTCTCCTGTGCC	0.468		NA	T	PDGFRB	MPD								82	25					0	0	0	0
PARP6	56965	broad.mit.edu	37	15	72534499	72534499	+	Silent	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr15:72534499T>C	uc002auc.2	-	21	2163	c.1704A>G	c.(1702-1704)GAA>GAG	p.E568E	PARP6_uc002aua.2_Silent_p.E414E|PARP6_uc002aub.2_RNA|PARP6_uc002aud.3_RNA|PARP6_uc002auf.1_Silent_p.E569E	NM_020214	NP_064599	Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	568	PARP catalytic.						NAD+ ADP-ribosyltransferase activity				0						GCTACCTACCTTCACAAAGTG	0.473		NA											15	9					0	0	0	0
PRKCB	5579	broad.mit.edu	37	16	24196444	24196444	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:24196444C>T	uc002dmd.2	+	14	1743	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	PRKCB_uc002dme.2_Nonsense_Mutation_p.Q516*	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	516	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	AATTGCTTATCAGCCCTATGG	0.433		NA											5	84					0	0	0	0
RBBP6	5930	broad.mit.edu	37	16	24580072	24580072	+	Silent	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:24580072A>G	uc002dmh.2	+	17	3101	c.2061A>G	c.(2059-2061)AAA>AAG	p.K687K	RBBP6_uc010vcb.1_Silent_p.K554K|RBBP6_uc002dmi.2_Silent_p.K653K|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Silent_p.K520K	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	687					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TTAGGTCTAAATCTCCCTATA	0.343		NA											17	37					0	0	0	0
SALL1	6299	broad.mit.edu	37	16	51171062	51171062	+	Silent	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:51171062G>C	uc010vgs.1	-	3	3967	c.3936C>G	c.(3934-3936)ACC>ACG	p.T1312T	SALL1_uc010vgr.1_Silent_p.T1215T|SALL1_uc010cbv.2_Silent_p.T164T	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1312					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCACGAAGCGGGTGAAGCGGA	0.567		NA											23	33					0	0	0	0
SALL1	6299	broad.mit.edu	37	16	51174418	51174418	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:51174418G>A	uc010vgs.1	-	2	1746	c.1715C>T	c.(1714-1716)ACG>ATG	p.T572M	SALL1_uc010vgr.1_Missense_Mutation_p.T475M|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	572					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCTCTTCCGTCTTGATGAA	0.602		NA											17	31					0	0	0	0
RLTPR	146206	broad.mit.edu	37	16	67682065	67682065	+	Silent	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:67682065C>A	uc002etn.2	+	14	1302	c.1182C>A	c.(1180-1182)ACC>ACA	p.T394T	RLTPR_uc010cel.1_Silent_p.T394T|RLTPR_uc010vjr.1_Intron	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	394	LRR 7.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GATGGATGACCGGCAGGGCGG	0.687		NA											10	11					3.07e-06	1.12e-05	1	0
SLC7A6OS	84138	broad.mit.edu	37	16	68336300	68336300	+	Silent	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:68336300T>C	uc002evw.1	-	4	802	c.783A>G	c.(781-783)GGA>GGG	p.G261G		NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	261					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		AATCCTCATCTCCATCACTGC	0.517		NA											80	100					0	0	0	0
KIAA0182	23199	broad.mit.edu	37	16	85687968	85687969	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr16:85687968_85687969GC>TT	uc002fix.2	+	4	585_586	c.511_512GC>TT	c.(511-513)GCC>TTC	p.A171F	KIAA0182_uc002fiw.2_Missense_Mutation_p.A67F|KIAA0182_uc002fiy.2_Missense_Mutation_p.A98F	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	171							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						AGGGGGACCAGCCATCCCCTCG	0.668		NA											8	17					0	0	0	0
POLR2A	5430	broad.mit.edu	37	17	7404147	7404147	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:7404147A>G	uc002ghf.3	+	11	2095	c.1861A>G	c.(1861-1863)ATC>GTC	p.I621V		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	621					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				TTACAAGCACATCTCTCCTGG	0.527		NA											31	87					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578524	7578524	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:7578524G>A	uc002gim.2	-	5	600	c.406C>T	c.(406-408)CAA>TAA	p.Q136*	TP53_uc002gig.1_Nonsense_Mutation_p.Q136*|TP53_uc002gih.2_Nonsense_Mutation_p.Q136*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q4*|TP53_uc010cng.1_Nonsense_Mutation_p.Q4*|TP53_uc002gii.1_Nonsense_Mutation_p.Q4*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q136*|TP53_uc010cni.1_Nonsense_Mutation_p.Q136*|TP53_uc002gij.2_Nonsense_Mutation_p.Q136*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.Q43*|TP53_uc002gio.2_Nonsense_Mutation_p.Q4*|TP53_uc010vug.1_Nonsense_Mutation_p.Q97*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.N131fs*27(2)|p.Q136fs*13(2)|p.Q136R(2)|p.Q136fs*34(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCCAGTTGGCAAAACATC	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			64	7					0	0	0	0
MYH4	4622	broad.mit.edu	37	17	10364246	10364246	+	Silent	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:10364246T>A	uc002gmn.2	-	12	1245	c.1134A>T	c.(1132-1134)CCA>CCT	p.P378P	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	378	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCGTGCCATCTGGCTCTGCCT	0.478		NA											30	69					0	0	0	0
USP22	23326	broad.mit.edu	37	17	20911270	20911270	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:20911270G>C	uc002gym.3	-	9	1347	c.1143C>G	c.(1141-1143)ATC>ATG	p.I381M	USP22_uc002gyn.3_Missense_Mutation_p.I369M|USP22_uc002gyl.3_Missense_Mutation_p.I276M	NM_015276	NP_056091	Q9UPT9	UBP22_HUMAN	ubiquitin thiolesterase 22	381					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1						CGCTGCACTTGATCTTGGCGC	0.488		NA											33	33					0	0	0	0
CCL1	6346	broad.mit.edu	37	17	32688843	32688843	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:32688843T>G	uc002hid.1	-	2	221	c.149A>C	c.(148-150)TAC>TCC	p.Y50S		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	50					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GGTATTTCTGTAACACAGGAT	0.493		NA									OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	110					0	0	0	0
TMEM132E	124842	broad.mit.edu	37	17	32953362	32953362	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:32953362G>A	uc002hif.2	+	2	612	c.284G>A	c.(283-285)GGG>GAG	p.G95E		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	95	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GTCTCTCTGGGGCCCTTCAGC	0.697		NA											8	24					0	0	0	0
PGAP3	93210	broad.mit.edu	37	17	37842182	37842182	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:37842182T>A	uc002hsj.2	-	2	315	c.272A>T	c.(271-273)CAT>CTT	p.H91L	ERBB2_uc002hsm.2_5'Flank|ERBB2_uc010cwa.2_5'Flank|PGAP3_uc010cvy.2_5'Flank|PGAP3_uc010wej.1_Missense_Mutation_p.H91L|PGAP3_uc002hsk.2_Missense_Mutation_p.H91L|PGAP3_uc010cvz.2_Missense_Mutation_p.H91L|ERBB2_uc002hsl.2_5'Flank	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	per1-like domain containing 1 precursor	91	Lumenal (Potential).				GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			upper_aerodigestive_tract(1)	1						CACCTTGCCATGGAACTGAGG	0.537		NA											13	17					0	0	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47243530	47243530	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:47243530C>T	uc002ion.2	+	9	1248	c.1189C>T	c.(1189-1191)CTC>TTC	p.L397F	B4GALNT2_uc010wlt.1_Missense_Mutation_p.L311F|B4GALNT2_uc010wlu.1_Missense_Mutation_p.L337F	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	397	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			CAAATACGTTCTCTGGGTGGA	0.468		NA											27	51					0	0	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48916922	48916922	+	Silent	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:48916922C>A	uc002isv.3	+	2	967	c.273C>A	c.(271-273)GCC>GCA	p.A91A	WFIKKN2_uc010dbu.2_5'UTR	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	91	WAP.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCGTGGCGGCCCGCTACATGG	0.582		NA											14	21					1.5e-05	5.44e-05	1	0
KIF2B	84643	broad.mit.edu	37	17	51901863	51901863	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr17:51901863C>A	uc002iua.2	+	1	1625	c.1469C>A	c.(1468-1470)CCT>CAT	p.P490H	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	490					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CAGAACAAGCCTCACACCCCA	0.527		NA											15	27					2.32e-05	8.38e-05	1	0
EMILIN2	84034	broad.mit.edu	37	18	2891658	2891658	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:2891658C>A	uc002kln.2	+	4	1692	c.1533C>A	c.(1531-1533)AAC>AAA	p.N511K		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	511					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TGACCAATAACACTGGTGCAG	0.527		NA											36	52					2.04e-09	7.7e-09	1	0
MYL12B	103910	broad.mit.edu	37	18	3273065	3273065	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:3273065A>G	uc010dkl.2	+	2	328	c.169A>G	c.(169-171)ATG>GTG	p.M57V	MYL12B_uc002klt.3_Missense_Mutation_p.M35V|MYL12B_uc010wyv.1_Missense_Mutation_p.M57V	NM_001144944	NP_001138416	O14950	ML12B_HUMAN	myosin regulatory light chain MRCL2 isoform A	57	EF-hand 1.				axon guidance|muscle contraction	cytosol|myosin complex	calcium ion binding				0						TTTGCATGATATGCTTGCTTC	0.343		NA											98	24					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	6976021	6976021	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:6976021G>A	uc002knm.2	-	45	6498	c.6404C>T	c.(6403-6405)TCC>TTC	p.S2135F	LAMA1_uc010wzj.1_Missense_Mutation_p.S1611F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2135	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTGGTAGAGGAAATCTGAGG	0.453		NA											5	54					0	0	0	0
POTEC	388468	broad.mit.edu	37	18	14543019	14543019	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:14543019T>C	uc010dln.2	-	1	581	c.127A>G	c.(127-129)ATG>GTG	p.M43V	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	43										skin(3)	3						GAAGTGCCCATGTTGCTCTTG	0.587		NA											4	149					0	0	0	0
SLC14A2	8170	broad.mit.edu	37	18	43224005	43224005	+	Missense_Mutation	SNP	C	C	T	rs139770269		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:43224005C>T	uc010dnj.2	+	11	1552	c.1231C>T	c.(1231-1233)CTC>TTC	p.L411F	SLC14A2_uc002lbb.2_Missense_Mutation_p.L411F|SLC14A2_uc002lbe.2_Missense_Mutation_p.L411F	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	411	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CATCTTCCTGCTCCTGACGAC	0.547		NA											73	103					0	0	0	0
MYO5B	4645	broad.mit.edu	37	18	47390534	47390534	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:47390534G>A	uc002leb.2	-	28	4108	c.3820C>T	c.(3820-3822)CGG>TGG	p.R1274W	MYO5B_uc002lea.2_Missense_Mutation_p.R415W	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1274					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GCGAGTCGCCGCTGGTCGGCG	0.617		NA											23	31					0	0	0	0
MEX3D	399664	broad.mit.edu	37	19	1556345	1556345	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:1556345G>A	uc010dsn.2	-	2	1173	c.1173C>T	c.(1171-1173)CGC>CGT	p.R391R		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	391					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGTCCCCGCGGAGGCCGG	0.801		NA											8	7					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	8993495	8993495	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:8993495C>T	uc002mkp.2	-	66	41798	c.41594G>A	c.(41593-41595)CGC>CAC	p.R13865H	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.R682H|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13868	Extracellular (Potential).|SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGGTCAGGGCGGTGGGTGCA	0.592		NA											47	39					0	0	0	0
ZNF559	84527	broad.mit.edu	37	19	9452988	9452988	+	Missense_Mutation	SNP	T	T	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:9452988T>G	uc002mlg.2	+	7	1508	c.861T>G	c.(859-861)CAT>CAG	p.H287Q	ZNF559_uc002mlf.2_Missense_Mutation_p.H56Q|ZNF559_uc010dwl.1_Missense_Mutation_p.H56Q|ZNF559_uc010xkn.1_Missense_Mutation_p.H279Q|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Missense_Mutation_p.H351Q|ZNF559_uc010dwk.1_Missense_Mutation_p.H56Q|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTGCTAAACATATAAGACTTA	0.333		NA											37	62					0	0	0	0
QTRT1	81890	broad.mit.edu	37	19	10823850	10823850	+	Silent	SNP	C	C	T	rs139740339	byFrequency	TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:10823850C>T	uc002mpr.2	+	10	1141	c.1116C>T	c.(1114-1116)TTC>TTT	p.F372F	DNM2_uc010dxk.2_RNA	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	372					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			TCCCGGACTTCGTGCGGGACT	0.657		NA											38	48					0	0	0	0
CYP4F8	11283	broad.mit.edu	37	19	15733053	15733053	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:15733053G>C	uc002nbi.2	+	8	614	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	184					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCTGGCCATGGAGGGCAGCAC	0.587		NA											16	27					0	0	0	0
MYO9B	4650	broad.mit.edu	37	19	17309083	17309083	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:17309083G>A	uc010eak.2	+	24	4356	c.4204G>A	c.(4204-4206)GCA>ACA	p.A1402T	MYO9B_uc002nfi.2_Missense_Mutation_p.A1402T|MYO9B_uc002nfj.1_Missense_Mutation_p.A1402T|MYO9B_uc002nfl.1_5'UTR	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1402	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CCTCCCAGACGCAGGGCTGTC	0.627		NA											17	37					0	0	0	0
UNC13A	23025	broad.mit.edu	37	19	17763482	17763482	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:17763482C>A	uc002nhd.2	-	13	1661	c.1661G>T	c.(1660-1662)CGG>CTG	p.R554L		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	466					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TCCTTCTCCCCGGGCCTGCAG	0.532		NA											101	198					1.44e-54	5.78e-54	1	0
ZNF493	284443	broad.mit.edu	37	19	21606219	21606219	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:21606219C>G	uc002npx.2	+	2	654	c.374C>G	c.(373-375)ACT>AGT	p.T125S	ZNF493_uc002npw.2_Missense_Mutation_p.T253S|ZNF493_uc002npy.2_Missense_Mutation_p.T125S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	125	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCAAACCTTACTACACATAAG	0.373		NA											13	36					0	0	0	0
ZNF675	171392	broad.mit.edu	37	19	23837318	23837318	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:23837318C>A	uc002nri.2	-	4	599	c.417G>T	c.(415-417)ATG>ATT	p.M139I		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	139					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTTTGCTCTGCATAGTTGGTA	0.299		NA											28	31					6.33e-13	2.42e-12	1	0
SUPT5H	6829	broad.mit.edu	37	19	39964118	39964118	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:39964118C>A	uc002olo.3	+	25	2628	c.2449C>A	c.(2449-2451)CAG>AAG	p.Q817K	SUPT5H_uc002olp.3_Missense_Mutation_p.Q817K|SUPT5H_uc002olq.3_Missense_Mutation_p.Q813K|SUPT5H_uc002oln.3_Missense_Mutation_p.Q817K|SUPT5H_uc002olr.3_Missense_Mutation_p.Q817K|SUPT5H_uc002ols.1_Missense_Mutation_p.Q440K|SUPT5H_uc010egp.1_3'UTR	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	817	CTR1-9.|9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CACTCCTGCCCAGAGTGGGGC	0.622		NA											29	14					7.26e-15	2.81e-14	1	0
CADM4	199731	broad.mit.edu	37	19	44127586	44127586	+	Missense_Mutation	SNP	A	A	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:44127586A>T	uc002oxc.1	-	9	1112	c.1063T>A	c.(1063-1065)TAT>AAT	p.Y355N		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	355	Cytoplasmic (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				TGGGTCAGATAGGAACCTGAG	0.483		NA											82	20					0	0	0	0
ZC3H4	23211	broad.mit.edu	37	19	47584783	47584783	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:47584783T>A	uc002pga.3	-	11	1465	c.1427A>T	c.(1426-1428)GAG>GTG	p.E476V	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	476							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		ATCCAAGAGCTCCCTCGTCTC	0.577		NA											22	12					0	0	0	0
CD33	945	broad.mit.edu	37	19	51728579	51728579	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:51728579C>T	uc002pwa.2	+	2	183	c.143C>T	c.(142-144)CCC>CTC	p.P48L	CD33_uc010eos.1_Missense_Mutation_p.P48L|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	48	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CATCCCATACCCTACTACGAC	0.517		NA											11	66					0	0	0	0
ZNF677	342926	broad.mit.edu	37	19	53740901	53740901	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:53740901G>A	uc002qbf.1	-	5	1264	c.1079C>T	c.(1078-1080)TCA>TTA	p.S360L	ZNF677_uc002qbg.1_Missense_Mutation_p.S360L	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	360	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		CCAAAGGTGTGAACGCTGGAT	0.393		NA											38	13					0	0	0	0
ATAD2B	54454	broad.mit.edu	37	2	24056880	24056881	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:24056880_24056881CC>AG	uc002rek.3	-	14	1930_1931	c.1636_1637GG>CT	c.(1636-1638)GGT>CTT	p.G546L	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rej.3_5'Flank	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	546							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTTGTAGCACCAATAACAACA	0.381		NA											13	24					0	0	0	0
REG3A	5068	broad.mit.edu	37	2	79385863	79385863	+	Silent	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:79385863G>T	uc002sod.1	-	2	364	c.109C>A	c.(109-111)CGG>AGG	p.R37R	REG3A_uc002soe.1_Silent_p.R37R|REG3A_uc002sof.1_Silent_p.R37R	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	37					acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						CAGCGGATCCGTGCAGAGGGC	0.552		NA											14	28					1.5e-05	5.44e-05	1	0
SLC9A2	6549	broad.mit.edu	37	2	103274384	103274384	+	Silent	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:103274384C>A	uc002tca.2	+	2	793	c.651C>A	c.(649-651)GTC>GTA	p.V217V		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	217	Helical; Name=F/M5A; (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TCTCAGCTGTCGATCCTGTGG	0.498		NA											108	148					3.11e-38	1.24e-37	1	0
SAP130	79595	broad.mit.edu	37	2	128747419	128747419	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:128747419G>C	uc002tpp.2	-	13	1709	c.1577C>G	c.(1576-1578)TCT>TGT	p.S526C	SAP130_uc002tpn.2_Missense_Mutation_p.S287C|SAP130_uc002tpo.2_Missense_Mutation_p.S271C|SAP130_uc010fmd.2_Missense_Mutation_p.S526C|SAP130_uc002tpq.1_Missense_Mutation_p.S499C	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	526					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TGTGATGGCAGAGTTTGGAGC	0.443		NA											19	29					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152534129	152534129	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:152534129C>A	uc010fnx.2	-	34	3915	c.3724G>T	c.(3724-3726)GAC>TAC	p.D1242Y		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1242	Nebulin 31.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACTGGGGAGTCCACAATGCTG	0.443		NA											35	74					3.9e-15	1.51e-14	1	0
XIRP2	129446	broad.mit.edu	37	2	168103945	168103945	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:168103945G>C	uc002udx.2	+	8	6061	c.6043G>C	c.(6043-6045)GAG>CAG	p.E2015Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E1840Q|XIRP2_uc010fpq.2_Missense_Mutation_p.E1793Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1840					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGAAAGAACTGAGGTTAATCT	0.438		NA											24	30					0	0	0	0
G6PC2	57818	broad.mit.edu	37	2	169764494	169764494	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:169764494T>A	uc002uem.2	+	5	1065	c.973T>A	c.(973-975)TTT>ATT	p.F325I	G6PC2_uc002uen.2_3'UTR|G6PC2_uc010fpv.2_Missense_Mutation_p.F209I	NM_021176	NP_066999	Q9NQR9	G6PC2_HUMAN	islet-specific glucose-6-phosphatase-related	325	Helical; (Potential).				gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			pancreas(1)	1						TGTGCTGTCTTTTTGTAAAAG	0.433		NA											23	138					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179443989	179443989	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179443989G>T	uc010zfg.1	-	269	60288	c.60064C>A	c.(60064-60066)CCT>ACT	p.P20022T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P13717T|TTN_uc010zfi.1_Missense_Mutation_p.P13650T|TTN_uc010zfj.1_Missense_Mutation_p.P13525T|uc002umv.1_Missense_Mutation_p.G72V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20949							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGCTAGAGGATCTTCCCCT	0.433		NA											39	63					1.59e-26	6.26e-26	1	0
TTN	7273	broad.mit.edu	37	2	179452482	179452482	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179452482A>G	uc010zfg.1	-	255	56074	c.55850T>C	c.(55849-55851)ATA>ACA	p.I18617T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I12312T|TTN_uc010zfi.1_Missense_Mutation_p.I12245T|TTN_uc010zfj.1_Missense_Mutation_p.I12120T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19544							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTCTCACTATGACCAGTTT	0.433		NA											24	41					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179604933	179604933	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:179604933C>G	uc010zfh.1	-	46	12738	c.12514G>C	c.(12514-12516)GAA>CAA	p.E4172Q	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4105Q|TTN_uc010zfj.1_Missense_Mutation_p.E3980Q|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAATGCTCTTCTTTGAGCAGT	0.473		NA											52	72					0	0	0	0
ITGAV	3685	broad.mit.edu	37	2	187506311	187506311	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:187506311C>T	uc002upq.2	+	12	1431	c.1155C>T	c.(1153-1155)TTC>TTT	p.F385F	ITGAV_uc010frs.2_Silent_p.F349F|ITGAV_uc010zfv.1_Silent_p.F339F	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	385	FG-GAP 6.|Potential.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		AGGATGGTTTCAATGGTAAGA	0.463		NA											59	77					0	0	0	0
TTLL4	9654	broad.mit.edu	37	2	219612322	219612322	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr2:219612322A>G	uc002viy.2	+	11	2622	c.2252A>G	c.(2251-2253)TAT>TGT	p.Y751C	TTLL4_uc010zkl.1_Missense_Mutation_p.Y586C|TTLL4_uc010fvx.2_Missense_Mutation_p.Y687C|TTLL4_uc010zkm.1_5'UTR	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	751	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTATGTAGGTATCTACACAAA	0.478		NA											54	23					0	0	0	0
PLCB4	5332	broad.mit.edu	37	20	9353027	9353027	+	Missense_Mutation	SNP	T	T	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:9353027T>A	uc002wnf.2	+	10	799	c.663T>A	c.(661-663)GAT>GAA	p.D221E	PLCB4_uc010gbw.1_Missense_Mutation_p.D221E|PLCB4_uc010gbx.2_Missense_Mutation_p.D221E|PLCB4_uc002wne.2_Missense_Mutation_p.D221E|PLCB4_uc002wnh.2_Missense_Mutation_p.D68E	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	221					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CTCGGACAGATATAGAAGATC	0.308		NA											14	36					0	0	0	0
NAA20	51126	broad.mit.edu	37	20	20013295	20013295	+	Missense_Mutation	SNP	A	A	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:20013295A>G	uc002wrp.2	+	5	553	c.449A>G	c.(448-450)TAT>TGT	p.Y150C	NAA20_uc002wrq.2_Intron|NAA20_uc002wrr.2_Missense_Mutation_p.Y138C	NM_016100	NP_057184	P61599	NAA20_HUMAN	N-acetyltransferase 5 isoform a	150	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity				0						GAGGACGCTTATGGTAAGCTC	0.408		NA											25	31					0	0	0	0
CD93	22918	broad.mit.edu	37	20	23065386	23065386	+	Missense_Mutation	SNP	C	C	T	rs142122866		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:23065386C>T	uc002wsv.2	-	1	1592	c.1444G>A	c.(1444-1446)GAT>AAT	p.D482N		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	482	Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCCTCCTCATCGGGGGGCCCA	0.657		NA											35	40					0	0	0	0
NINL	22981	broad.mit.edu	37	20	25485703	25485703	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:25485703T>C	uc002wux.1	-	6	603	c.529A>G	c.(529-531)ACC>GCC	p.T177A	NINL_uc010gdn.1_Missense_Mutation_p.T177A|NINL_uc010gdo.1_Missense_Mutation_p.T17A|NINL_uc010ztf.1_Missense_Mutation_p.T193A	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	177					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GAATCCCAGGTCTGCAGCTGT	0.443		NA											4	9					0	0	0	0
PHACTR3	116154	broad.mit.edu	37	20	58342414	58342414	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:58342414C>T	uc002yau.2	+	5	1182	c.715C>T	c.(715-717)CCC>TCC	p.P239S	PHACTR3_uc002yat.2_Missense_Mutation_p.P236S|PHACTR3_uc010zzw.1_Missense_Mutation_p.P198S|PHACTR3_uc002yav.2_Missense_Mutation_p.P198S|PHACTR3_uc002yaw.2_Missense_Mutation_p.P198S|PHACTR3_uc002yax.2_Intron	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	239	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CACTCCGCCACCCAAGGCAAG	0.537		NA											21	24					0	0	0	0
NCAM2	4685	broad.mit.edu	37	21	22849748	22849748	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr21:22849748C>G	uc002yld.1	+	15	2282	c.2033C>G	c.(2032-2034)ACA>AGA	p.T678R	NCAM2_uc011acb.1_Missense_Mutation_p.T536R	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	678	Fibronectin type-III 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TCTGAACCGACAGTTTATGAA	0.368		NA											16	14					0	0	0	0
GART	2618	broad.mit.edu	37	21	34877966	34877966	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr21:34877966C>G	uc002yrx.2	-	20	2762	c.2627G>C	c.(2626-2628)AGT>ACT	p.S876T	GART_uc002yrz.2_Missense_Mutation_p.S876T|GART_uc010gmd.2_Missense_Mutation_p.S538T|GART_uc002yry.2_Missense_Mutation_p.S876T	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	876	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	GTCAATTGCACTGTCAAATTC	0.338		NA											22	6					0	0	0	0
PI4KA	5297	broad.mit.edu	37	22	21178651	21178651	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr22:21178651G>A	uc002zsz.3	-	4	476	c.245C>T	c.(244-246)TCT>TTT	p.S82F	PI4KA_uc010gsq.1_Missense_Mutation_p.S140F	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	82					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GGCCACATCAGACAGCAGAGT	0.443		NA											18	33					0	0	0	0
GRM2	2912	broad.mit.edu	37	3	51743449	51743449	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:51743449G>A	uc010hlv.2	+	2	689	c.450G>A	c.(448-450)CAG>CAA	p.Q150Q	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	150	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TCTCCATCCAGGTACGTGGAA	0.582		NA											6	4					0	0	0	0
IMPG2	50939	broad.mit.edu	37	3	100963028	100963028	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:100963028G>C	uc003duq.1	-	13	2350	c.2147C>G	c.(2146-2148)TCA>TGA	p.S716*	IMPG2_uc011bhe.1_Nonsense_Mutation_p.S579*	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	716	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TTTGGTAACTGAGTAATCATC	0.473		NA											14	7					0	0	0	0
KIAA1407	57577	broad.mit.edu	37	3	113721347	113721347	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:113721347G>A	uc003eax.2	-	12	2164	c.2017C>T	c.(2017-2019)CGG>TGG	p.R673W	KIAA1407_uc011bin.1_RNA	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	673	Potential.									ovary(2)	2						GCCAAGATCCGCCTACATTCA	0.328		NA											38	8					0	0	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133666147	133666147	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:133666147G>C	uc003eqa.3	-	9	1522	c.1248C>G	c.(1246-1248)TTC>TTG	p.F416L	SLCO2A1_uc003eqb.3_Missense_Mutation_p.F340L|SLCO2A1_uc011blv.1_Missense_Mutation_p.F235L	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	416	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						ATCCCATGAAGAACAAAGGAA	0.493		NA											36	55					0	0	0	0
ACPL2	92370	broad.mit.edu	37	3	140998227	140998227	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:140998227C>T	uc003etu.2	+	6	545	c.246C>T	c.(244-246)GCC>GCT	p.A82A	ACPL2_uc003etv.2_Silent_p.A82A|ACPL2_uc011bna.1_Silent_p.A44A|ACPL2_uc011bnb.1_Silent_p.A65A	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	82						extracellular region	acid phosphatase activity			skin(1)	1						CAGGTCATGCCCCGCATCATT	0.498		NA									OREG0015847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	145	28					0	0	0	0
ECE2	9718	broad.mit.edu	37	3	183995809	183995809	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:183995809C>A	uc003fni.3	+	5	967	c.929C>A	c.(928-930)GCC>GAC	p.A310D	ECE2_uc011brg.1_Missense_Mutation_p.A238D|ECE2_uc011brh.1_Missense_Mutation_p.A163D|ECE2_uc003fnl.3_Missense_Mutation_p.A238D|ECE2_uc003fnm.3_Missense_Mutation_p.A192D|ECE2_uc003fnk.3_Missense_Mutation_p.A163D|ECE2_uc011bri.1_Missense_Mutation_p.A225D|ECE2_uc010hxv.2_5'UTR	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	310	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAGCTGGGAGCCCAGCCACTG	0.577		NA											120	13					1.37e-49	5.49e-49	1	0
C4orf35	85438	broad.mit.edu	37	4	71201610	71201610	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:71201610T>C	uc003hff.2	+	1	940	c.854T>C	c.(853-855)CTG>CCG	p.L285P		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	285						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				GAAGATACTCTGCTAACTGAT	0.418		NA											19	12					0	0	0	0
TIFA	92610	broad.mit.edu	37	4	113199415	113199415	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:113199415G>A	uc003ial.2	-	2	440	c.158C>T	c.(157-159)TCC>TTC	p.S53F		NM_052864	NP_443096	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with a	53	FHA.						protein binding			breast(1)	1		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		ACAGATGTTGGAATTTCGGCC	0.403		NA											41	24					0	0	0	0
ADCY2	108	broad.mit.edu	37	5	7789843	7789843	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:7789843G>A	uc003jdz.1	+	20	2625	c.2558G>A	c.(2557-2559)CGC>CAC	p.R853H	ADCY2_uc011cmo.1_Missense_Mutation_p.R673H|ADCY2_uc010itm.1_Missense_Mutation_p.R49H	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	853	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AACCTGAACCGCGTGCTGCTG	0.532		NA											35	77					0	0	0	0
PRDM9	56979	broad.mit.edu	37	5	23526620	23526620	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:23526620G>A	uc003jgo.2	+	11	1605	c.1423G>A	c.(1423-1425)GCC>ACC	p.A475T		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	475					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GATTTCAAGGGCCTTTTCTAG	0.453		NA								HNSCC(3;0.000094)			10	23					0	0	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140812032	140812032	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:140812032C>T	uc003lkt.1	+	1	1875	c.1706C>T	c.(1705-1707)ACG>ATG	p.T569M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.T569M	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	569	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTCCCCACGGACGGTTCC	0.677		NA											91	42					0	0	0	0
SLIT3	6586	broad.mit.edu	37	5	168112761	168112761	+	Silent	SNP	G	G	A	rs148625020		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr5:168112761G>A	uc003mab.2	-	31	3906	c.3486C>T	c.(3484-3486)TTC>TTT	p.F1162F	SLIT3_uc010jjg.2_Silent_p.F1169F	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1162	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTTGCCCACGAAGTTGACAG	0.657		NA											24	14					0	0	0	0
RNF39	80352	broad.mit.edu	37	6	30043353	30043353	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:30043353G>A	uc003npe.2	-	1	276	c.214C>T	c.(214-216)CCC>TCC	p.P72S	RNF39_uc003npd.2_Missense_Mutation_p.P72S	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	72						cytoplasm	zinc ion binding				0						CCCAGCTCGGGCGCATCCATG	0.711		NA											10	7					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117658469	117658469	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:117658469G>A	uc003pxp.1	-	31	5313	c.5114C>T	c.(5113-5115)TCA>TTA	p.S1705L	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1705	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTGGCTGCATGAAGTTTTAAC	0.308		NA	T	GOPC|ROS1	glioblastoma|NSCLC								30	35					0	0	0	0
SERINC1	57515	broad.mit.edu	37	6	122766322	122766322	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:122766322T>C	uc003pyy.1	-	10	1299	c.1229A>G	c.(1228-1230)TAT>TGT	p.Y410C	SERINC1_uc003pyx.1_RNA	NM_020755	NP_065806	Q9NRX5	SERC1_HUMAN	serine incorporator 1	410	Lumenal (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.126)		AGAGGGTTCATACCTAAAATT	0.428		NA											17	15					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129826387	129826387	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:129826387G>C	uc003qbn.2	+	60	8695	c.8590G>C	c.(8590-8592)GAT>CAT	p.D2864H	LAMA2_uc003qbo.2_Missense_Mutation_p.D2860H|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2864	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCTTTATGTAGATGGGGCTTC	0.413		NA											34	35					0	0	0	0
SAMD3	154075	broad.mit.edu	37	6	130505272	130505272	+	Silent	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:130505272G>A	uc003qbv.2	-	8	956	c.630C>T	c.(628-630)TTC>TTT	p.F210F	SAMD3_uc003qbx.2_Silent_p.F210F|SAMD3_uc003qbw.2_Silent_p.F210F|SAMD3_uc010kfg.1_Silent_p.F210F|SAMD3_uc003qby.2_Silent_p.F210F|SAMD3_uc003qbz.1_Silent_p.F169F	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	210										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CCTCATCCAGGAAAGGGTGGG	0.468		NA											26	34					0	0	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582515	136582515	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:136582515C>A	uc003qgx.1	-	12	2898	c.2645G>T	c.(2644-2646)GGT>GTT	p.G882V	BCLAF1_uc011edb.1_Missense_Mutation_p.G161V|BCLAF1_uc003qgw.1_Missense_Mutation_p.G709V|BCLAF1_uc003qgy.1_Missense_Mutation_p.G831V|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.G880V	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	882					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGGACTGCTACCTGATTTTTT	0.438		NA											55	245					3.46e-24	1.36e-23	1	0
TCP10	6953	broad.mit.edu	37	6	167790110	167790110	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:167790110C>A	uc003qvv.1	-	5	712	c.500G>T	c.(499-501)CGT>CTT	p.R167L	TCP10_uc003qvu.2_Missense_Mutation_p.R167L|TCP10_uc003qvw.2_Missense_Mutation_p.R143L	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	194						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		TCTGTCTTGACGTCTCCCGGG	0.507		NA											26	6					9.04e-19	3.53e-18	1	0
TMEM195	392636	broad.mit.edu	37	7	15599809	15599809	+	Missense_Mutation	SNP	C	C	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:15599809C>A	uc003stb.1	-	2	384	c.214G>T	c.(214-216)GCT>TCT	p.A72S		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	72					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						GACGTTAAAGCATCATCCAGG	0.443		NA											85	68					4.46e-32	1.77e-31	1	0
ZNF716	441234	broad.mit.edu	37	7	57529191	57529191	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:57529191C>T	uc011kdi.1	+	4	1136	c.1024C>T	c.(1024-1026)CAT>TAT	p.H342Y		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						CCTTAAGAAACATAAGATAGT	0.388		NA											30	16					0	0	0	0
POM121	9883	broad.mit.edu	37	7	72413673	72413673	+	Silent	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:72413673C>T	uc003twk.2	+	11	3141	c.3141C>T	c.(3139-3141)TTC>TTT	p.F1047F	POM121_uc003twj.2_Silent_p.F782F|POM121_uc010lam.1_Silent_p.F782F	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1047	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CTTCGGCCTTCGGCGCTCCCG	0.647		NA											7	199					0	0	0	0
GRM3	2913	broad.mit.edu	37	7	86493648	86493648	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:86493648G>A	uc003uid.2	+	6	3716	c.2617G>A	c.(2617-2619)GAC>AAC	p.D873N	GRM3_uc010lef.2_Missense_Mutation_p.R515Q|GRM3_uc010leg.2_Missense_Mutation_p.D745N|GRM3_uc010leh.2_Missense_Mutation_p.D465N	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	873	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGAAGTCCTCGACTCCACCAC	0.448		NA											73	122					0	0	0	0
STEAP4	79689	broad.mit.edu	37	7	87910251	87910251	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:87910251C>T	uc003ujs.2	-	4	1233	c.1128G>A	c.(1126-1128)TGG>TGA	p.W376*	STEAP4_uc010lek.2_Nonsense_Mutation_p.W200*	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	376	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					GGAACTCTCTCCAGTTGACTG	0.378		NA											45	110					0	0	0	0
ZNF394	84124	broad.mit.edu	37	7	99097557	99097557	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:99097557G>T	uc003uqs.2	-	1	321	c.160C>A	c.(160-162)CCC>ACC	p.P54T	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.P54T	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	54					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GAAGCCGCGGGATAGTTGGGC	0.642		NA											43	50					1.15e-24	4.53e-24	1	0
LAMB4	22798	broad.mit.edu	37	7	107696109	107696109	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:107696109G>C	uc010ljo.1	-	25	3807	c.3723C>G	c.(3721-3723)TTC>TTG	p.F1241L	LAMB4_uc003vey.2_Missense_Mutation_p.F1241L|LAMB4_uc010ljp.1_Missense_Mutation_p.F210L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1241	Domain II.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGACTTTTAAGAATTTCCCAG	0.413		NA											49	101					0	0	0	0
DOCK4	9732	broad.mit.edu	37	7	111540505	111540505	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:111540505C>T	uc003vfx.2	-	15	1674	c.1405G>A	c.(1405-1407)GAA>AAA	p.E469K	DOCK4_uc003vfy.2_Missense_Mutation_p.E469K|DOCK4_uc003vga.1_Missense_Mutation_p.E74K	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	469	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TTCAGCAGTTCAGACCACCTG	0.498		NA											14	15					0	0	0	0
TFEC	22797	broad.mit.edu	37	7	115624462	115624462	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr7:115624462G>C	uc003vhj.1	-	2	218	c.34C>G	c.(34-36)CTT>GTT	p.L12V	TFEC_uc003vhk.1_Missense_Mutation_p.L12V|TFEC_uc003vhl.3_Missense_Mutation_p.L12V|TFEC_uc011kmw.1_Missense_Mutation_p.L102V	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	12	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			GACCATTTAAGAGTTGGATTG	0.493		NA											54	108					0	0	0	0
TUSC3	7991	broad.mit.edu	37	8	15601046	15601046	+	Splice_Site	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:15601046G>T	uc003wwt.2	+	8	1073	c.863_splice	c.e8-1	p.N288_splice	TUSC3_uc003wwu.2_Splice_Site_p.N288_splice|TUSC3_uc003wwv.2_Splice_Site_p.N288_splice|TUSC3_uc003www.2_Splice_Site_p.N288_splice|TUSC3_uc003wwx.2_Splice_Site|TUSC3_uc003wwy.2_Splice_Site_p.M267_splice	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a						cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		AACTACTGCAGATGCCGCTAT	0.403		NA											23	137					5.35e-11	2.04e-10	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110457673	110457673	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:110457673G>T	uc003yne.2	+	38	5679	c.5575G>T	c.(5575-5577)GGC>TGC	p.G1859C		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1859	Extracellular (Potential).|IPT/TIG 11.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTTCTATCCAGGCAACACTAC	0.502		NA								HNSCC(38;0.096)			39	7					6.97e-18	2.72e-17	1	0
FAM84B	157638	broad.mit.edu	37	8	127569333	127569333	+	Missense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr8:127569333G>A	uc003yrz.1	-	2	586	c.302C>T	c.(301-303)TCG>TTG	p.S101L		NM_174911	NP_777571	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	101						cytoplasm|plasma membrane	protein binding				0	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			CAGCGCCGCCGAGCCCGGCGC	0.657		NA											31	17					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971098	21971098	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:21971098C>G	uc003zpk.2	-	2	472	c.260G>C	c.(259-261)CGG>CCG	p.R87P	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.P142P	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	87	ANK 3.		R -> P (in CMM2; impairs the function).|R -> W (in CMM2; partial loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.H83fs*2(2)|p.D84_F90del(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.R87W(1)|p.R87L(1)|p.E61_L94del(1)|p.R87Q(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.R87fs(1)|p.E87K(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GAAGCCCTCCCGGGCAGCGTC	0.751		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	3					0	0	0	0
KIAA1161	57462	broad.mit.edu	37	9	34371549	34371549	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:34371549C>G	uc003zue.3	-	3	1560	c.1393G>C	c.(1393-1395)GGC>CGC	p.G465R		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	465	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CTGACCTCGCCCGCGTCGAAC	0.672		NA											2	7					0	0	0	0
TMEM2	23670	broad.mit.edu	37	9	74332991	74332991	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:74332991G>A	uc011lsa.1	-	13	2812	c.2272C>T	c.(2272-2274)CGA>TGA	p.R758*	TMEM2_uc010mos.2_Nonsense_Mutation_p.R695*|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	758						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGATGAGGTCGAAATCTAGGG	0.338		NA											27	37					0	0	0	0
VPS13A	23230	broad.mit.edu	37	9	79853254	79853254	+	Missense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:79853254G>T	uc004akr.2	+	19	2112	c.1852G>T	c.(1852-1854)GCA>TCA	p.A618S	VPS13A_uc004akp.3_Missense_Mutation_p.A618S|VPS13A_uc004akq.3_Missense_Mutation_p.A618S|VPS13A_uc004aks.2_Missense_Mutation_p.A618S	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	618					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						ACAGCTCACTGCAGCAACTTT	0.348		NA											29	39					3.48e-35	1.38e-34	1	0
KIAA1529	57653	broad.mit.edu	37	9	100090306	100090306	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:100090306G>T	uc011lut.1	+	28	2988	c.2215G>T	c.(2215-2217)GAA>TAA	p.E739*	KIAA1529_uc004axe.1_Nonsense_Mutation_p.E739*|KIAA1529_uc004axg.1_Nonsense_Mutation_p.E600*|KIAA1529_uc004axh.1_5'Flank|KIAA1529_uc011luw.1_5'Flank|KIAA1529_uc011lus.1_Nonsense_Mutation_p.E557*|KIAA1529_uc010msm.1_Intron|KIAA1529_uc004axf.2_Nonsense_Mutation_p.E600*|KIAA1529_uc011luv.1_Nonsense_Mutation_p.E597*	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCCCAGGTATGAATGTTTTCA	0.517		NA											86	118					2.62e-37	1.04e-36	1	0
ASTN2	23245	broad.mit.edu	37	9	119976967	119976967	+	Missense_Mutation	SNP	C	C	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:119976967C>T	uc004bjs.1	-	3	786	c.685G>A	c.(685-687)GCC>ACC	p.A229T	ASTN2_uc004bjr.1_Missense_Mutation_p.A229T|ASTN2_uc004bjt.1_Missense_Mutation_p.A229T	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	229	Cytoplasmic (Potential).		A -> V (found in a clear cell renal carcinoma case; somatic mutation).			integral to membrane		p.A229V(1)		skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGTCGCTGGGCGTACAGCGCC	0.607		NA											31	36					0	0	0	0
NAIF1	203245	broad.mit.edu	37	9	130829161	130829161	+	Missense_Mutation	SNP	C	C	G			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr9:130829161C>G	uc004bta.2	-	1	439	c.220G>C	c.(220-222)GAC>CAC	p.D74H	NAIF1_uc004bsz.2_RNA|SLC25A25_uc004btb.2_5'Flank	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	74					apoptosis|induction of apoptosis	nucleus					0						GTCTTGAGGTCAGACCACTTC	0.697		NA											83	12					0	0	0	0
THOC2	57187	broad.mit.edu	37	X	122774415	122774415	+	Missense_Mutation	SNP	T	T	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chrX:122774415T>C	uc004etu.2	-	16	1752	c.1720A>G	c.(1720-1722)AGC>GGC	p.S574G	THOC2_uc011muh.1_Missense_Mutation_p.S495G	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	574					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GTTGGATTGCTGTGGCTCAAC	0.383		NA											60	5					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135404984	135404984	+	Missense_Mutation	SNP	G	G	C			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chrX:135404984G>C	uc004ezu.1	+	5	409	c.118G>C	c.(118-120)GAC>CAC	p.D40H	GPR112_uc010nsb.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	40	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGGAAGAGGTGACACATATGT	0.388		NA											38	9					0	0	0	0
ENO1	2023	broad.mit.edu	37	1	8926383	8926385	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:8926383_8926385delCCA	uc001apj.1	-	7	771_773	c.620_622delTGG	c.(619-624)GTGGGG>GGG	p.V207del	ENO1_uc001api.1_In_Frame_Del_p.V111del|ENO1_uc001apk.1_In_Frame_Del_p.V152del|ENO1_uc001apl.1_In_Frame_Del_p.V207del|ENO1_uc009vmi.1_In_Frame_Del_p.V164del|ENO1_uc009vmj.1_In_Frame_Del_p.V207del|ENO1_uc009vmk.1_In_Frame_Del_p.V81del|ENO1_uc009vml.1_In_Frame_Del_p.V207del	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	207	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CCTTCATCCCCCACATTGGTGGC	0.552		NA											52	29	---	---	---	---	NA	NA	NA	NA
ZNF238	10472	broad.mit.edu	37	1	244217124	244217125	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr1:244217124_244217125insA	uc001iae.2	+	1	543_544	c.21_22insA	c.(19-24)AGTAGAfs	p.S7fs	ZNF238_uc001iad.3_Frame_Shift_Ins_p.S16fs|ZNF238_uc001iaf.1_Frame_Shift_Ins_p.S7fs	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	7_8					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			CAGACCATAGTAGACATTTGCT	0.51		NA											27	38	---	---	---	---	NA	NA	NA	NA
MAP3K12	7786	broad.mit.edu	37	12	53875912	53875913	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:53875912_53875913insT	uc001sdm.1	-	14	2391_2392	c.2293_2294insA	c.(2293-2295)AGTfs	p.S765fs	MAP3K12_uc001sdn.1_Frame_Shift_Ins_p.S798fs	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	765					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						GGAAGGTTCACTAGCTGTGCCT	0.554		NA									OREG0021873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	73	93	---	---	---	---	NA	NA	NA	NA
NAV3	89795	broad.mit.edu	37	12	78400648	78400648	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr12:78400648delC	uc001syp.2	+	8	1503	c.1330delC	c.(1330-1332)CCTfs	p.P444fs	NAV3_uc001syo.2_Frame_Shift_Del_p.P444fs	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	444						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAAAGTGTCACCTAAGTTGGC	0.408		NA								HNSCC(70;0.22)			34	68	---	---	---	---	NA	NA	NA	NA
JUB	84962	broad.mit.edu	37	14	23451332	23451332	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr14:23451332delC	uc001whz.2	-	1	520	c.144delG	c.(142-144)GGGfs	p.G48fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	48	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CTCCTCGGGGCCCTGACTTCC	0.682		NA											115	12	---	---	---	---	NA	NA	NA	NA
MBD1	4152	broad.mit.edu	37	18	47800213	47800214	+	Frame_Shift_Ins	INS	-	-	AC			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr18:47800213_47800214insAC	uc010dow.1	-	12	1603_1604	c.1166_1167insGT	c.(1165-1167)GTCfs	p.V389fs	MBD1_uc002lef.2_Frame_Shift_Ins_p.V140fs|MBD1_uc002leg.2_Frame_Shift_Ins_p.V339fs|MBD1_uc010xdi.1_Frame_Shift_Ins_p.V440fs|MBD1_uc002leh.3_Frame_Shift_Ins_p.V333fs|MBD1_uc002len.2_Frame_Shift_Ins_p.V389fs|MBD1_uc002lei.3_Frame_Shift_Ins_p.V389fs|MBD1_uc002lej.3_Frame_Shift_Ins_p.V333fs|MBD1_uc002lek.3_Frame_Shift_Ins_p.V340fs|MBD1_uc002lel.3_Frame_Shift_Ins_p.V366fs|MBD1_uc002lem.3_Frame_Shift_Ins_p.V389fs|MBD1_uc010xdj.1_Frame_Shift_Ins_p.V333fs|MBD1_uc010xdk.1_Frame_Shift_Ins_p.V414fs|MBD1_uc010dox.1_Frame_Shift_Ins_p.V366fs|MBD1_uc002leo.2_Frame_Shift_Ins_p.V389fs	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	389					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACTCTGACCAGACACTGGGCAG	0.609		NA											43	91	---	---	---	---	NA	NA	NA	NA
ZNF208	7757	broad.mit.edu	37	19	22154308	22154308	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr19:22154308delT	uc002nqp.2	-	6	3293	c.3144delA	c.(3142-3144)AAAfs	p.K1048fs	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAACAAAGCCTTTGCCACATT	0.383		NA											10	66	---	---	---	---	NA	NA	NA	NA
PPP1R3D	5509	broad.mit.edu	37	20	58514574	58514577	+	Frame_Shift_Del	DEL	TTGA	TTGA	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr20:58514574_58514577delTTGA	uc002ybb.2	-	1	776_779	c.410_413delTCAA	c.(409-414)ATCAACfs	p.I137fs	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	137_138					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CAGGTCCGAGTTGATTGCGAGCCG	0.681		NA											22	26	---	---	---	---	NA	NA	NA	NA
EIF4G1	1981	broad.mit.edu	37	3	184039744	184039746	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr3:184039744_184039746delGAA	uc003fnp.2	+	10	1570_1572	c.1372_1374delGAA	c.(1372-1374)GAAdel	p.E465del	EIF4G1_uc003fno.1_In_Frame_Del_p.E406del|EIF4G1_uc010hxw.1_In_Frame_Del_p.E301del|EIF4G1_uc003fnt.2_In_Frame_Del_p.E176del|EIF4G1_uc003fnq.2_In_Frame_Del_p.E378del|EIF4G1_uc003fnr.2_In_Frame_Del_p.E301del|EIF4G1_uc010hxx.2_In_Frame_Del_p.E472del|EIF4G1_uc003fns.2_In_Frame_Del_p.E425del|EIF4G1_uc010hxy.2_In_Frame_Del_p.E472del|EIF4G1_uc003fnv.3_In_Frame_Del_p.E465del|EIF4G1_uc003fnu.3_In_Frame_Del_p.E465del|EIF4G1_uc003fnw.2_In_Frame_Del_p.E472del|EIF4G1_uc003fnx.2_In_Frame_Del_p.E269del|EIF4G1_uc003fny.3_In_Frame_Del_p.E269del	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	465	Poly-Glu.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGGAAATGgaagaagaagaag	0.443		NA											7	190	---	---	---	---	NA	NA	NA	NA
USP38	84640	broad.mit.edu	37	4	144106780	144106780	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr4:144106780delG	uc003ijb.2	+	1	711	c.177delG	c.(175-177)CAGfs	p.Q59fs	USP38_uc003ija.3_Frame_Shift_Del_p.Q59fs|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	59					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					TCCAGCGGCAGGTGGGGCACC	0.627		NA											17	9	---	---	---	---	NA	NA	NA	NA
HIST1H2BG	8339	broad.mit.edu	37	6	26216820	26216831	+	In_Frame_Del	DEL	CCTTCTTGGAAC	CCTTCTTGGAAC	-	rs143774290		TCGA-CN-6997-01A-11D-2012-08	TCGA-CN-6997-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	11b531cc-d9d9-496a-8448-e654ba71c414	1ec354c8-1eb5-4f54-96ab-3e66d87e167f	g.chr6:26216820_26216831delCCTTCTTGGAAC	uc003ngz.2	-	1	42_53	c.41_52delGTTCCAAGAAGG	c.(40-54)GGTTCCAAGAAGGCT>GCT	p.GSKK14del	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	14_17					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding	p.K17E(1)		ovary(1)	1		all_hematologic(11;0.196)				TTGGTCACAGCCTTCTTGGAACCCTTCTTCGG	0.491		NA											32	48	---	---	---	---	NA	NA	NA	NA