Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CACHD1	57685	broad.mit.edu	37	1	65047921	65047921	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:65047921C>T	uc001dbo.1	+	3	296	c.191C>T	c.(190-192)ACG>ATG	p.T64M	CACHD1_uc001dbp.1_Translation_Start_Site|CACHD1_uc001dbq.1_Translation_Start_Site	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	115	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						GCATCCTATACGGCTCACCTA	0.428		NA											29	70					0	0	0	0
AHCYL1	10768	broad.mit.edu	37	1	110563392	110563392	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:110563392C>T	uc001dyx.2	+	16	1872	c.1505C>T	c.(1504-1506)GCC>GTC	p.A502V	AHCYL1_uc010ovw.1_Missense_Mutation_p.A455V|AHCYL1_uc001dyy.2_Missense_Mutation_p.A455V|AHCYL1_uc010ovx.1_Missense_Mutation_p.A455V	NM_006621	NP_006612	O43865	SAHH2_HUMAN	S-adenosylhomocysteine hydrolase-like 1	502					one-carbon metabolic process	endoplasmic reticulum	adenosylhomocysteinase activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0259)|Colorectal(144;0.123)|all cancers(265;0.134)|Epithelial(280;0.141)|LUSC - Lung squamous cell carcinoma(189;0.143)		TCATTTGATGCCCACCTTACA	0.433		NA											4	153					0	0	0	0
SPAG17	200162	broad.mit.edu	37	1	118629569	118629569	+	Silent	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:118629569G>A	uc001ehk.2	-	11	1490	c.1422C>T	c.(1420-1422)GAC>GAT	p.D474D		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	474						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GGTCTAGCCCGTCTGCTCTGG	0.517		NA											28	59					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527		NA											11	31					0	0	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161160954	161160954	+	Missense_Mutation	SNP	G	G	A	rs114728887	by1000genomes	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:161160954G>A	uc001fyt.3	-	9	2916	c.2488C>T	c.(2488-2490)CGG>TGG	p.R830W		NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	830	Spacer.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CAGGGGCGCCGCCGAAGGATC	0.637		NA											11	26					0	0	0	0
TNR	7143	broad.mit.edu	37	1	175375720	175375720	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:175375720G>A	uc001gkp.1	-	1	212	c.131C>T	c.(130-132)TCA>TTA	p.S44L	TNR_uc009wwu.1_Missense_Mutation_p.S44L|TNR_uc010pmz.1_Missense_Mutation_p.S44L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	44					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CTCCTCCACTGACTGTCTCTG	0.517		NA											19	115					0	0	0	0
ACTA1	58	broad.mit.edu	37	1	229568748	229568748	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr1:229568748G>A	uc001htm.2	-	2	220	c.115C>T	c.(115-117)CGC>TGC	p.R39C		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	39					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	TGTCGGGGGCGGCCCACGATG	0.726		NA											5	33					0	0	0	0
TMEM72	643236	broad.mit.edu	37	10	45430313	45430313	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr10:45430313A>G	uc001jbn.2	+	5	756	c.559A>G	c.(559-561)AAG>GAG	p.K187E	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.K69E	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	187						integral to membrane					0						CATCCACATGAAGAGTATCCT	0.602		NA											46	156					0	0	0	0
PSAP	5660	broad.mit.edu	37	10	73578462	73578462	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr10:73578462G>A	uc001jsm.2	-	13	1555	c.1451C>T	c.(1450-1452)TCG>TTG	p.S484L	PSAP_uc001jsl.2_Missense_Mutation_p.S208L	NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	484	Saposin B-type 4.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CTTATGGGCCGAGGGGCAGGC	0.488		NA											8	125					0	0	0	0
ARL3	403	broad.mit.edu	37	10	104445679	104445679	+	Missense_Mutation	SNP	G	G	A	rs150077149		TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr10:104445679G>A	uc001kwa.2	-	5	553	c.395C>T	c.(394-396)ACA>ATA	p.T132I		NM_004311	NP_004302	P36405	ARL3_HUMAN	ADP-ribosylation factor-like 3	132					cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding				0		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)		AGGGGCTGCTGTGAGCAAATC	0.507		NA											15	43					0	0	0	0
TH	7054	broad.mit.edu	37	11	2191095	2191095	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:2191095G>A	uc001lvq.2	-	3	209	c.190C>T	c.(190-192)CGG>TGG	p.R64W	TH_uc001lvp.2_Missense_Mutation_p.R60W|TH_uc001lvr.2_Missense_Mutation_p.R33W|TH_uc010qxj.1_Missense_Mutation_p.R37W|TH_uc001lvs.2_Missense_Mutation_p.R33W|TH_uc001lvt.2_Missense_Mutation_p.R37W|TH_uc009ydh.1_5'Flank	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	64					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	CCAATGAACCGCGGGGACTGT	0.721		NA											3	10					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62290908	62290908	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:62290908T>C	uc001ntl.2	-	5	11281	c.10981A>G	c.(10981-10983)ATG>GTG	p.M3661V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3661					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATCTCAGGCATCTTGAACTTG	0.468		NA											55	177					0	0	0	0
PYGM	5837	broad.mit.edu	37	11	64521023	64521023	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:64521023C>T	uc001oax.3	-	11	2188	c.1371G>A	c.(1369-1371)GCG>GCA	p.A457A	PYGM_uc001oay.3_Silent_p.A369A	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	457					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	AGTGGATGCGCGCCACGCCGT	0.652		NA											3	5					0	0	0	0
FEZ1	9638	broad.mit.edu	37	11	125359382	125359382	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr11:125359382C>A	uc001qbx.2	-	2	444	c.292G>T	c.(292-294)GAG>TAG	p.E98*	FEZ1_uc010sbc.1_Nonsense_Mutation_p.E98*|FEZ1_uc001qby.1_Nonsense_Mutation_p.E98*	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	98	Poly-Glu.				axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		TGAAGGGTCTCCTCCTCCTCT	0.493		NA											7	61					0.00198382	0.00217653	1	0
HSP90B1	7184	broad.mit.edu	37	12	104340443	104340443	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr12:104340443C>T	uc001tkb.1	+	15	2180	c.2075C>T	c.(2074-2076)CCG>CTG	p.P692L	HSP90B1_uc010swg.1_Missense_Mutation_p.P357L|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	692					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CCCAGACACCCGCTGATCAGA	0.323		NA											14	60					0	0	0	0
KSR2	283455	broad.mit.edu	37	12	118199176	118199176	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr12:118199176T>C	uc001two.2	-	4	594	c.539A>G	c.(538-540)TAT>TGT	p.Y180C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	209	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTGACAATAGTGCTGGAC	0.687		NA											7	19					0	0	0	0
GCN1L1	10985	broad.mit.edu	37	12	120621395	120621395	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr12:120621395G>T	uc001txo.2	-	5	416	c.403C>A	c.(403-405)CAA>AAA	p.Q135K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	135					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATGTCTCCTTGTCGCTTGGCT	0.542		NA											3	73					0.00909568	0.00970206	1	0
FEM1B	10116	broad.mit.edu	37	15	68582025	68582025	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr15:68582025A>G	uc002arg.2	+	2	944	c.329A>G	c.(328-330)CAT>CGT	p.H110R	FEM1B_uc002arh.2_Missense_Mutation_p.H30R	NM_015322	NP_056137	Q9UK73	FEM1B_HUMAN	fem-1 homolog b	110	ANK 2.				apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity				0						CTAGTCAGCCATGGAGCCAAC	0.448		NA											10	24					0	0	0	0
DNAH3	55567	broad.mit.edu	37	16	20999384	20999384	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:20999384C>T	uc010vbe.1	-	45	6605	c.6605G>A	c.(6604-6606)CGA>CAA	p.R2202Q	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2202	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCGAGTGAATCGTCCTGGGGA	0.453		NA											14	46					0	0	0	0
PHKB	5257	broad.mit.edu	37	16	47644777	47644777	+	Silent	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:47644777G>A	uc002eev.3	+	14	1456	c.1404G>A	c.(1402-1404)CAG>CAA	p.Q468Q	PHKB_uc002eeu.3_Silent_p.Q461Q	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	468					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				ATCCTGTCCAGCGCTATGTCC	0.338		NA											13	34					0	0	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53686477	53686477	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:53686477C>A	uc002ehp.2	-	15	2186	c.2122G>T	c.(2122-2124)GGC>TGC	p.G708C	RPGRIP1L_uc002eho.3_Missense_Mutation_p.G708C|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.G708C|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.G708C|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.G708C	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	708	C2 1.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				AATATTCGGCCGCTTTTTTCA	0.348		NA											14	38					0.00316338	0.00343146	1	0
ZFHX3	463	broad.mit.edu	37	16	72830437	72830437	+	Silent	SNP	T	T	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:72830437T>G	uc002fck.2	-	9	6817	c.6144A>C	c.(6142-6144)CCA>CCC	p.P2048P	ZFHX3_uc002fcl.2_Silent_p.P1134P	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2048	Poly-Pro.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GAAGTGGGGGTGGAGGGGGTG	0.642		NA											4	28					0	0	0	0
CBFA2T3	863	broad.mit.edu	37	16	88958773	88958773	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr16:88958773G>T	uc002fmm.1	-	4	686	c.500C>A	c.(499-501)CCA>CAA	p.P167Q	CBFA2T3_uc002fml.1_Missense_Mutation_p.P81Q|CBFA2T3_uc010cif.1_Missense_Mutation_p.P106Q|CBFA2T3_uc002fmn.1_Missense_Mutation_p.P142Q	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	167	Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCCGCAGGCTGGGGGCAGGTG	0.647		NA	T	RUNX1	AML								18	23					4.35e-09	5.06e-09	1	0
POLR2A	5430	broad.mit.edu	37	17	7399844	7399844	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:7399844G>A	uc002ghf.3	+	4	683	c.449G>A	c.(448-450)GGC>GAC	p.G150D	POLR2A_uc002ghe.2_Missense_Mutation_p.G150D	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	150					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CTTTGCAAGGGCAAAAACATA	0.537		NA											4	158					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577142	7577142	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:7577142C>T	uc002gim.2	-	8	990	c.796G>A	c.(796-798)GGA>AGA	p.G266R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134R|TP53_uc010cng.1_Missense_Mutation_p.G134R|TP53_uc002gii.1_Missense_Mutation_p.G134R|TP53_uc010cnh.1_Missense_Mutation_p.G266R|TP53_uc010cni.1_Missense_Mutation_p.G266R|TP53_uc002gij.2_Missense_Mutation_p.G266R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(31)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGTTCCGTCCCAGTAGATTA	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	11					0	0	0	0
PSMD11	5717	broad.mit.edu	37	17	30796051	30796051	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:30796051C>T	uc010cta.1	+	6	523	c.483C>T	c.(481-483)GAC>GAT	p.D161D	PSMD11_uc010wbz.1_Silent_p.D161D|PSMD11_uc002hhm.2_Silent_p.D161D	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	161					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			AAAAGATGGACGACAAAGCTC	0.448		NA											14	33					0	0	0	0
NAGS	162417	broad.mit.edu	37	17	42083499	42083499	+	Missense_Mutation	SNP	T	T	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr17:42083499T>A	uc002ies.2	+	3	809	c.809T>A	c.(808-810)GTG>GAG	p.V270E	PYY_uc002ieq.2_5'Flank|NAGS_uc010czn.2_Missense_Mutation_p.V270E|NAGS_uc002iet.2_5'UTR	NM_153006	NP_694551	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	270					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity				0		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	CGCCGCTCCGTGCTTCTCGAC	0.667		NA											10	16					0	0	0	0
LRRC30	339291	broad.mit.edu	37	18	7231400	7231400	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:7231400C>T	uc010wzk.1	+	1	264	c.264C>T	c.(262-264)CCC>CCT	p.P88P		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	88	LRR 1.									ovary(1)|liver(1)	2						TTCTCCCTCCCGAGGTGGGGA	0.587		NA											9	24					0	0	0	0
DSG1	1828	broad.mit.edu	37	18	28934345	28934345	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:28934345C>T	uc002kwp.2	+	15	2398	c.2186C>T	c.(2185-2187)CCT>CTT	p.P729L	DSG1_uc010xbp.1_Missense_Mutation_p.P88L	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	729	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GTAGGTTCCCCTGCTGGCTCT	0.453		NA											32	54					0	0	0	0
C18orf54	162681	broad.mit.edu	37	18	51892104	51892104	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:51892104C>T	uc002lfn.3	+	5	872	c.756C>T	c.(754-756)CCC>CCT	p.P252P	C18orf54_uc002lfo.3_Silent_p.P413P	NM_173529	NP_775800	Q8IYD9	CR054_HUMAN	hypothetical protein LOC162681 precursor	252						extracellular region				ovary(1)|skin(1)	2				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		CTCCTGTTCCCGTTAACTCTG	0.333		NA											39	120					0	0	0	0
TSHZ1	10194	broad.mit.edu	37	18	72999367	72999367	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr18:72999367G>A	uc002lly.2	+	2	2433	c.1870G>A	c.(1870-1872)GCT>ACT	p.A624T		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	669						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CCTGGCCAAGGCTGCGTCCCC	0.572		NA											14	31					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9010979	9010979	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:9010979G>T	uc002mkp.2	-	37	39143	c.38939C>A	c.(38938-38940)CCC>CAC	p.P12980H	MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTGCTGGTGGGGGCCACAGA	0.517		NA											25	66					6.13e-19	7.26e-19	1	0
ILF3	3609	broad.mit.edu	37	19	10791116	10791116	+	Silent	SNP	G	G	A	rs150021624	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:10791116G>A	uc002mpn.2	+	9	1271	c.954G>A	c.(952-954)GCG>GCA	p.A318A	ILF3_uc002mpm.2_Silent_p.A318A|ILF3_uc002mpl.2_Silent_p.A318A|ILF3_uc002mpk.2_Silent_p.A318A|ILF3_uc010xli.1_Intron|ILF3_uc002mpo.2_Silent_p.A318A|ILF3_uc002mpp.2_Silent_p.A139A	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	318	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CACAGAGTGCGCAGGTATAGT	0.507		NA											5	33					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22157207	22157207	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:22157207A>G	uc002nqp.2	-	4	778	c.629T>C	c.(628-630)TTT>TCT	p.F210S	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGACCAGTTAAAAGCTTTGCC	0.368		NA											18	49					0	0	0	0
GGN	199720	broad.mit.edu	37	19	38877088	38877088	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:38877088C>T	uc002oij.1	-	3	949	c.814G>A	c.(814-816)GGA>AGA	p.G272R	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Missense_Mutation_p.G189R	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	272	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCGCCGCCTCCGCCGCCCCCC	0.647		NA											8	41					0	0	0	0
PPP5C	5536	broad.mit.edu	37	19	46879819	46879819	+	Silent	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:46879819A>G	uc002pem.2	+	4	681	c.621A>G	c.(619-621)AAA>AAG	p.K207K	PPP5C_uc010xya.1_Silent_p.K74K|PPP5C_uc002pen.2_Silent_p.K207K	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	207	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		TGCACCGGAAATGTGCCTACC	0.547		NA											10	25					0	0	0	0
ZNF616	90317	broad.mit.edu	37	19	52619805	52619805	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr19:52619805C>T	uc002pym.2	-	4	895	c.612G>A	c.(610-612)CAG>CAA	p.Q204Q	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	204	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		TATGTATCCTCTGATGATTAA	0.393		NA											42	93					0	0	0	0
CKAP2L	150468	broad.mit.edu	37	2	113514030	113514030	+	Silent	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:113514030A>G	uc002tie.2	-	4	997	c.918T>C	c.(916-918)AAT>AAC	p.N306N	CKAP2L_uc002tif.2_Intron|CKAP2L_uc010yxp.1_Silent_p.N141N|CKAP2L_uc010yxq.1_Silent_p.N141N	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	306						centrosome					0						ATTGACTCCTATTAACCTTTA	0.408		NA											22	72					0	0	0	0
OBSL1	23363	broad.mit.edu	37	2	220422717	220422717	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:220422717C>T	uc010fwk.2	-	11	3675	c.3618G>A	c.(3616-3618)TGG>TGA	p.W1206*	OBSL1_uc002vmh.1_Nonsense_Mutation_p.W197*|OBSL1_uc010zli.1_Nonsense_Mutation_p.W105*|OBSL1_uc010fwl.1_Nonsense_Mutation_p.W681*	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1206	Ig-like 10.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CATTGTGGCTCCAGACCACGG	0.687		NA											4	12					0	0	0	0
WDFY1	57590	broad.mit.edu	37	2	224749380	224749380	+	Silent	SNP	C	C	G	rs140777534		TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:224749380C>G	uc002vnq.2	-	9	969	c.918G>C	c.(916-918)ACG>ACC	p.T306T		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	306	FYVE-type.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		TTAGCCCCAGCGTCTTGGTGT	0.453		NA											57	208					0	0	0	0
SP110	3431	broad.mit.edu	37	2	231067413	231067413	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr2:231067413C>T	uc002vqh.3	-	9	1170	c.930G>A	c.(928-930)AAG>AAA	p.K310K	SP110_uc002vqg.3_Silent_p.K310K|SP110_uc002vqi.3_Silent_p.K310K|SP110_uc010fxk.2_Silent_p.K308K|SP110_uc010fxj.2_Intron	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	310					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TTTTGAGCTTCTTTTGGATTC	0.458		NA											27	84					0	0	0	0
ATRN	8455	broad.mit.edu	37	20	3543984	3543984	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr20:3543984C>T	uc002wim.2	+	10	1850	c.1760C>T	c.(1759-1761)TCT>TTT	p.S587F	ATRN_uc002wil.2_Missense_Mutation_p.S587F	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	587	Extracellular (Potential).|Kelch 5.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						AAATGCTTCTCTTCAGATTTC	0.428		NA											9	163					0	0	0	0
ZNF335	63925	broad.mit.edu	37	20	44581029	44581029	+	Silent	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr20:44581029G>A	uc002xqw.2	-	20	3069	c.2946C>T	c.(2944-2946)TGC>TGT	p.C982C	ZNF335_uc002xqv.2_Silent_p.C94C|ZNF335_uc010zxk.1_Silent_p.C827C	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	982					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				AGTCCCCTACGCAGTGGGTCT	0.662		NA											20	39					0	0	0	0
TSSK2	23617	broad.mit.edu	37	22	19119046	19119046	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr22:19119046G>A	uc002zow.2	+	1	726	c.134G>A	c.(133-135)CGC>CAC	p.R45H	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	45	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					ATCATCGACCGCAAGAAAACA	0.488		NA											3	31					0	0	0	0
FGD5	152273	broad.mit.edu	37	3	14862067	14862067	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:14862067G>A	uc003bzc.2	+	1	1599	c.1489G>A	c.(1489-1491)GTC>ATC	p.V497I	FGD5_uc011avk.1_Missense_Mutation_p.V497I	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	497					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CCCAGAAACCGTCCCTGAAGA	0.642		NA											5	36					0	0	0	0
SENP7	57337	broad.mit.edu	37	3	101066766	101066766	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:101066766T>C	uc003dut.2	-	13	1898	c.1787A>G	c.(1786-1788)TAT>TGT	p.Y596C	SENP7_uc003duu.2_Missense_Mutation_p.Y531C|SENP7_uc003duv.2_Missense_Mutation_p.Y563C|SENP7_uc003duw.2_Missense_Mutation_p.Y530C|SENP7_uc003dux.2_Missense_Mutation_p.Y432C	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	596					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						CTCTTGAAGATAATCTGAAGA	0.338		NA											19	71					0	0	0	0
EPHB1	2047	broad.mit.edu	37	3	134880873	134880873	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:134880873T>G	uc003eqt.2	+	7	1656	c.1436T>G	c.(1435-1437)TTC>TGC	p.F479C	EPHB1_uc003equ.2_Missense_Mutation_p.F40C	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	479	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CACAATGAGTTCAACTCCTCC	0.547		NA											3	73					0	0	0	0
ZIC4	84107	broad.mit.edu	37	3	147113851	147113851	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:147113851G>A	uc003ewd.1	-	3	749	c.476C>T	c.(475-477)ACC>ATC	p.T159I	ZIC4_uc003ewc.1_Missense_Mutation_p.T89I|ZIC4_uc011bno.1_Missense_Mutation_p.T209I	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	159	C2H2-type 1; atypical.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GTGCTCCACGGTGACGTGCGT	0.612		NA											4	128					0	0	0	0
NCBP2	22916	broad.mit.edu	37	3	196669371	196669371	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr3:196669371A>T	uc003fxd.1	-	1	94	c.4T>A	c.(4-6)TCG>ACG	p.S2T	NCBP2_uc003fxb.1_5'Flank|NCBP2_uc011btz.1_5'Flank|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Missense_Mutation_p.S2T|NCBP2_uc003fxf.2_Missense_Mutation_p.S2T|LOC152217_uc003fxg.3_5'Flank	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	2					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		AGGCCACCCGACATAGTGCAG	0.682		NA									OREG0016012	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	14					0	0	0	0
NCAPG	64151	broad.mit.edu	37	4	17827167	17827167	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr4:17827167G>A	uc003gpp.2	+	11	1812	c.1636G>A	c.(1636-1638)GAA>AAA	p.E546K	NCAPG_uc011bxj.1_Missense_Mutation_p.E55K	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	546					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TGAAATTAAAGAAGTCCACAT	0.308		NA											6	48					0	0	0	0
RBM47	54502	broad.mit.edu	37	4	40440251	40440251	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr4:40440251C>T	uc003gvc.2	-	4	1370	c.660G>A	c.(658-660)CAG>CAA	p.Q220Q	RBM47_uc003gvd.2_Silent_p.Q220Q|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.Q182Q|RBM47_uc003gvg.1_Silent_p.Q220Q	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	220	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						GGCCCCACAGCTGGATGCGGC	0.647		NA											26	44					0	0	0	0
TLL1	7092	broad.mit.edu	37	4	167020437	167020437	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr4:167020437G>A	uc003irh.1	+	20	3312	c.2665G>A	c.(2665-2667)GGA>AGA	p.G889R	TLL1_uc011cjn.1_Missense_Mutation_p.G912R|TLL1_uc011cjo.1_Missense_Mutation_p.G713R	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	889	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AGAGTGTGGCGGACGATTGAA	0.418		NA											12	48					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13701428	13701428	+	Missense_Mutation	SNP	A	A	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:13701428A>T	uc003jfd.2	-	77	13498	c.13456T>A	c.(13456-13458)TTT>ATT	p.F4486I	DNAH5_uc003jfc.2_Missense_Mutation_p.F654I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4486					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGGGGGTTAAAAAAACCCGTC	0.423		NA							Kartagener_syndrome				63	84					0	0	0	0
LIFR	3977	broad.mit.edu	37	5	38506632	38506632	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:38506632C>T	uc010ive.1	-	8	1426	c.1094G>A	c.(1093-1095)CGT>CAT	p.R365H	LIFR_uc003jli.2_Missense_Mutation_p.R365H	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	365	Fibronectin type-III 2.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					GCTTGTAGCACGTGGGCCCAC	0.423		NA	T	PLAG1	salivary adenoma								31	51					0	0	0	0
MAP1B	4131	broad.mit.edu	37	5	71492289	71492289	+	Missense_Mutation	SNP	C	C	T	rs145156470	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:71492289C>T	uc003kbw.3	+	5	3348	c.3107C>T	c.(3106-3108)CCG>CTG	p.P1036L	MAP1B_uc010iyw.1_Missense_Mutation_p.P1053L|MAP1B_uc010iyx.1_Missense_Mutation_p.P910L|MAP1B_uc010iyy.1_Missense_Mutation_p.P910L	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1036						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GAATATGAGCCGGAAAAAATG	0.522		NA											21	49					0	0	0	0
CHD1	1105	broad.mit.edu	37	5	98233025	98233025	+	Splice_Site	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:98233025C>T	uc003knf.2	-	10	1514	c.1366_splice	c.e10-1	p.V456_splice		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GTTTTAATACCTTTAGTAGAA	0.308		NA											17	54					0	0	0	0
PCDHA13	56136	broad.mit.edu	37	5	140264049	140264049	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:140264049C>T	uc003lif.2	+	1	2196	c.2196C>T	c.(2194-2196)TGC>TGT	p.C732C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.C732C|PCDHA13_uc003lid.2_Silent_p.C732C	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	732	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGCGCGTGCGCGCCGGGCA	0.672		NA											28	64					0	0	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553676	140553676	+	Silent	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr5:140553676C>T	uc003lit.2	+	1	1434	c.1260C>T	c.(1258-1260)ACC>ACT	p.T420T		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	420	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAACATCACCATCACCGTCA	0.512		NA											4	63					0	0	0	0
DUSP22	56940	broad.mit.edu	37	6	348266	348266	+	Missense_Mutation	SNP	G	G	T	rs147464089	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr6:348266G>T	uc003msx.2	+	6	866	c.427G>T	c.(427-429)GTC>TTC	p.V143F	DUSP22_uc011dhn.1_Missense_Mutation_p.V143F|DUSP22_uc003msy.1_Missense_Mutation_p.V100F	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	143					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GAAGCATGAGGTCCATCAGGT	0.582		NA											4	46					2.56e-06	2.91e-06	1	0
SLC26A8	116369	broad.mit.edu	37	6	35919019	35919019	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr6:35919019C>A	uc003olm.2	-	19	2504	c.2393G>T	c.(2392-2394)AGG>ATG	p.R798M	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.R380M|SLC26A8_uc003oln.2_Missense_Mutation_p.R798M|SLC26A8_uc003oll.2_Missense_Mutation_p.R693M	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	798	Interaction with RACGAP1.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						TATGACCTTCCTTGACAAGGC	0.493		NA											15	43					4.15e-12	4.86e-12	1	0
RSPO3	84870	broad.mit.edu	37	6	127476478	127476478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr6:127476478C>T	uc003qar.2	+	4	819	c.529C>T	c.(529-531)CGA>TGA	p.R177*	RSPO3_uc003qas.1_Nonsense_Mutation_p.R177*	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	177	TSP type-1.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		AACACGGGTCCGAGAAATAAT	0.463		NA											28	58					0	0	0	0
ACTB	60	broad.mit.edu	37	7	5567491	5567491	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr7:5567491A>G	uc003sos.3	-	5	1052	c.1016T>C	c.(1015-1017)GTG>GCG	p.V339A	ACTB_uc003sor.3_Missense_Mutation_p.V217A|ACTB_uc003sot.3_Missense_Mutation_p.V339A|ACTB_uc003soq.3_Missense_Mutation_p.V217A|ACTB_uc010ksy.2_Missense_Mutation_p.V217A	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	339					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GCCGATCCACACGGAGTACTT	0.622		NA											9	36					0	0	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762359	92762359	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr7:92762359C>T	uc003umh.1	-	5	4142	c.2926G>A	c.(2926-2928)GTT>ATT	p.V976I	SAMD9L_uc003umj.1_Missense_Mutation_p.V976I|SAMD9L_uc003umi.1_Missense_Mutation_p.V976I|SAMD9L_uc010lfb.1_Missense_Mutation_p.V976I|SAMD9L_uc003umk.1_Missense_Mutation_p.V976I|SAMD9L_uc010lfc.1_Missense_Mutation_p.V976I|SAMD9L_uc010lfd.1_Missense_Mutation_p.V976I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	976										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TATTCTGCAACTTCTGTTTTT	0.383		NA											18	47					0	0	0	0
TUSC3	7991	broad.mit.edu	37	8	15601052	15601052	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:15601052G>A	uc003wwt.2	+	8	1078	c.868G>A	c.(868-870)GCT>ACT	p.A290T	TUSC3_uc003wwu.2_Missense_Mutation_p.A290T|TUSC3_uc003wwv.2_Missense_Mutation_p.A290T|TUSC3_uc003www.2_Missense_Mutation_p.A290T|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Silent_p.P268P	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	290	Helical; (Potential).				cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		TGCAGATGCCGCTATCACCAT	0.393		NA											45	46					0	0	0	0
RP1	6101	broad.mit.edu	37	8	55539978	55539978	+	Missense_Mutation	SNP	T	T	C			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:55539978T>C	uc003xsd.1	+	4	3684	c.3536T>C	c.(3535-3537)TTG>TCG	p.L1179S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1179					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GCTGATGACTTGAAAGCTGCT	0.408		NA											3	176					0	0	0	0
ZFHX4	79776	broad.mit.edu	37	8	77775641	77775641	+	Missense_Mutation	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:77775641A>G	uc003yav.2	+	11	9943	c.9556A>G	c.(9556-9558)AAA>GAA	p.K3186E		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3182						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGTGTTGGGCAAAGTTGTAGG	0.438		NA								HNSCC(33;0.089)			13	144					0	0	0	0
RALYL	138046	broad.mit.edu	37	8	85799858	85799858	+	Silent	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:85799858G>A	uc003ycq.3	+	9	1121	c.705G>A	c.(703-705)TTG>TTA	p.L235L	RALYL_uc003ycr.3_Silent_p.L235L|RALYL_uc003ycs.3_Silent_p.L235L|RALYL_uc010lzy.2_Silent_p.L224L|RALYL_uc003yct.3_Silent_p.L248L|RALYL_uc003ycu.3_Silent_p.L162L|RALYL_uc003ycv.3_Intron	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	235	Potential.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						AGAAGCAATTGGAAGAGAGTC	0.488		NA											10	108					0	0	0	0
CYP11B1	1584	broad.mit.edu	37	8	143957228	143957228	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:143957228G>A	uc003yxi.2	-	6	1028	c.1021C>T	c.(1021-1023)CGC>TGC	p.R341C	CYP11B1_uc010mex.2_Missense_Mutation_p.R17C|CYP11B1_uc003yxh.2_Missense_Mutation_p.R57C|CYP11B1_uc003yxj.2_Missense_Mutation_p.R341C|CYP11B1_uc010mey.2_Missense_Mutation_p.R412C	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	341					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTCTCCTGGCGCAGGGCCTGC	0.642		NA							Familial_Hyperaldosteronism_type_I				93	81					0	0	0	0
NAPRT1	93100	broad.mit.edu	37	8	144657851	144657851	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr8:144657851C>T	uc003yym.3	-	9	1154	c.1129G>A	c.(1129-1131)GGC>AGC	p.G377S	C8orf73_uc010mff.2_5'Flank|C8orf73_uc010mfg.1_5'Flank|NAPRT1_uc003yyn.3_Missense_Mutation_p.G377S|NAPRT1_uc011lkh.1_Missense_Mutation_p.G377S|NAPRT1_uc003yyo.3_Missense_Mutation_p.G377S	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	377					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GTGCCAATGCCAATGACATTC	0.667		NA											5	7					0	0	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88203249	88203249	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:88203249A>C	uc011ltd.1	-	20	2900	c.2867T>G	c.(2866-2868)GTC>GGC	p.V956G	AGTPBP1_uc004aod.3_Missense_Mutation_p.V582G|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.V916G|AGTPBP1_uc011lte.1_Missense_Mutation_p.V968G	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	956					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						TAACATAGGGACAATTTTAAA	0.348		NA											13	30					0	0	0	0
OMD	4958	broad.mit.edu	37	9	95177520	95177520	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:95177520C>T	uc004asd.3	-	3	1549	c.1180G>A	c.(1180-1182)GAT>AAT	p.D394N	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron	NM_005014	NP_005005	Q99983	OMD_HUMAN	osteomodulin precursor	394	Asp/Glu-rich (acidic).				cell adhesion	proteinaceous extracellular matrix				ovary(2)	2						TCAGGATCATCGTGATCTTCA	0.368		NA	T	USP6	aneurysmal bone cysts								26	38					0	0	0	0
BSPRY	54836	broad.mit.edu	37	9	116132021	116132021	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:116132021G>A	uc004bhg.3	+	6	856	c.808G>A	c.(808-810)GAC>AAC	p.D270N	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	270	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GGAGCGCTTCGACCACTGGCC	0.577		NA											15	51					0	0	0	0
SEC16A	9919	broad.mit.edu	37	9	139371059	139371059	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:139371059G>A	uc004chx.2	-	3	1318	c.1009C>T	c.(1009-1011)CTC>TTC	p.L337F	SEC16A_uc004chv.3_5'Flank|SEC16A_uc004chw.2_Missense_Mutation_p.L337F|SEC16A_uc010nbn.2_Missense_Mutation_p.L337F|SEC16A_uc010nbo.1_Missense_Mutation_p.L337F	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	159					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CCCCGGGCGAGGGGGTTCACA	0.617		NA											7	39					0	0	0	0
SUV39H1	6839	broad.mit.edu	37	X	48558589	48558589	+	Silent	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:48558589G>A	uc004dkn.2	+	3	318	c.273G>A	c.(271-273)AAG>AAA	p.K91K	SUV39H1_uc011mmf.1_Silent_p.K102K|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	91	Chromo.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						AGTTCCACAAGGACTTAGAAA	0.567		NA											3	9					0	0	0	0
ZNF711	7552	broad.mit.edu	37	X	84523345	84523345	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:84523345C>T	uc004eeo.2	+	7	1309	c.962C>T	c.(961-963)TCA>TTA	p.S321L	ZNF711_uc004eep.2_Missense_Mutation_p.S321L|ZNF711_uc004eeq.2_Missense_Mutation_p.S367L|ZNF711_uc011mqy.1_5'UTR	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	321					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TGTCAAGCATCAGGTAAGAGA	0.303		NA											14	26					0	0	0	0
ZBTB33	10009	broad.mit.edu	37	X	119388776	119388776	+	Silent	SNP	A	A	G			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:119388776A>G	uc004esn.1	+	2	1734	c.1506A>G	c.(1504-1506)TCA>TCG	p.S502S	ZBTB33_uc010nqm.1_Silent_p.S502S	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	502	Interaction with CTNND1 (By similarity).|C2H2-type 1.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GCAAAAGGTCATATGTCTGTC	0.383		NA											12	115					0	0	0	0
MST4	51765	broad.mit.edu	37	X	131205199	131205199	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:131205199G>A	uc004ewk.1	+	8	1187	c.886G>A	c.(886-888)GCA>ACA	p.A296T	MST4_uc004ewl.1_Missense_Mutation_p.A219T|MST4_uc011mux.1_Missense_Mutation_p.A318T|MST4_uc010nrj.1_Missense_Mutation_p.A296T|MST4_uc004ewm.1_Missense_Mutation_p.A234T	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	296					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					GAGATGGAAGGCAGAAGGACA	0.328		NA											35	97					0	0	0	0
FGF13	2258	broad.mit.edu	37	X	137791006	137791006	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:137791006C>T	uc004fam.2	-	2	934	c.272G>A	c.(271-273)GGC>GAC	p.G91D	FGF13_uc004fan.2_Missense_Mutation_p.G38D|FGF13_uc011mwi.1_Missense_Mutation_p.G72D|FGF13_uc004faq.2_Missense_Mutation_p.G101D|FGF13_uc004far.2_Missense_Mutation_p.G72D|FGF13_uc011mwj.1_Missense_Mutation_p.G101D|FGF13_uc011mwk.1_Missense_Mutation_p.G45D	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	91					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ATCTTTGGTGCCATCAATGGT	0.393		NA											38	167					0	0	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696765	153696765	+	Silent	SNP	C	C	T	rs140160422	byFrequency	TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:153696765C>T	uc004flm.2	+	23	4256	c.4083C>T	c.(4081-4083)CGC>CGT	p.R1361R		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1361	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCGCGACCGCGGCACCGTGG	0.667		NA											9	24					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971045	21971059	+	In_Frame_Del	DEL	CCAGCCGCGCCCCGG	CCAGCCGCGCCCCGG	-	rs143282362		TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chr9:21971045_21971059delCCAGCCGCGCCCCGG	uc003zpk.2	-	2	511_525	c.299_313delCCGGGGCGCGGCTGG	c.(298-315)GCCGGGGCGCGGCTGGAC>GAC	p.AGARL100del	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_In_Frame_Del_p.155_160GRGAAG>G	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	100_104	ANK 3.		Missing.		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.G101G(3)|p.A100S(3)|p.A102V(3)|p.L104fs*42(2)|p.D105fs*41(2)|p.A102A(2)|p.A102E(2)|p.A100P(2)|p.H83fs*2(2)|p.R103Q(1)|p.R103R(1)|p.T93_D105del(1)|p.A100V(1)|p.G101fs*17(1)|p.A68fs*3(1)|p.A102fs*18(1)|p.R103fs*43(1)|p.G101W(1)|p.D105N(1)|p.A102P(1)|p.A102T(1)|p.A102fs*42(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCGCGCACGTCCAGCCGCGCCCCGGCCCGGTGCAG	0.758		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			21	30	---	---	---	---	NA	NA	NA	NA
HUWE1	10075	broad.mit.edu	37	X	53562382	53562384	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CQ-5330-01A-01D-1683-08	TCGA-CQ-5330-10A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4ce7e702-9b62-459e-b2b4-a26cabba3a93	690340f2-8307-43ea-ac77-21828b243e05	g.chrX:53562382_53562384delCTT	uc004dsp.2	-	81	13012_13014	c.12610_12612delAAG	c.(12610-12612)AAGdel	p.K4204del	HUWE1_uc004dsn.2_In_Frame_Del_p.K3012del	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4204	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.K4094del(1)		ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GTACATACTCCTTCTTATTCTCC	0.438		NA											19	61	---	---	---	---	NA	NA	NA	NA