Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
IPO7	10527	broad.mit.edu	37	11	9466668	9466668	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr11:9466668G>C	uc001mho.2	+	25	3186	c.3044G>C	c.(3043-3045)GGA>GCA	p.G1015A		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	1015					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		GAGAAGCATGGAGGATACAAA	0.378		NA											11	135					0	0	0	0
CKAP5	9793	broad.mit.edu	37	11	46810308	46810308	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr11:46810308C>T	uc001ndi.1	-	16	2001	c.1891G>A	c.(1891-1893)GAC>AAC	p.D631N	CKAP5_uc009ylg.1_Missense_Mutation_p.D517N|CKAP5_uc001ndj.1_Missense_Mutation_p.D631N	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	631					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TCAGTTCGGTCCATTAGCTCA	0.308		NA											41	75					0	0	0	0
USP35	57558	broad.mit.edu	37	11	77921098	77921098	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr11:77921098G>A	uc009yva.1	+	10	2443	c.2197G>A	c.(2197-2199)GAA>AAA	p.E733K	USP35_uc001oze.2_Missense_Mutation_p.E489K|USP35_uc001ozc.2_Missense_Mutation_p.E301K|USP35_uc010rsp.1_Missense_Mutation_p.E165K|USP35_uc001ozd.2_Missense_Mutation_p.E344K|USP35_uc001ozf.2_Missense_Mutation_p.E464K	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	733					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			ggaaaaggaagaagaCAGCCT	0.333		NA											30	60					0	0	0	0
GALNT6	11226	broad.mit.edu	37	12	51751183	51751183	+	Missense_Mutation	SNP	C	C	T	rs142431103		TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr12:51751183C>T	uc001ryk.2	-	9	1777	c.1552G>A	c.(1552-1554)GGG>AGG	p.G518R	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.G518R|GALNT6_uc001ryj.1_Missense_Mutation_p.G83R	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	518	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GGCTTCCCCCCGCGGTTGTTC	0.612		NA											21	57					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104107482	104107482	+	Silent	SNP	C	C	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr12:104107482C>A	uc001tjw.2	+	42	4659	c.4473C>A	c.(4471-4473)ACC>ACA	p.T1491T	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1491	Extracellular (Potential).|EGF-like 12.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTAAGAGAACCACCCCAGGAA	0.542		NA											100	273					8.45e-40	9.6e-40	1	0
CIT	11113	broad.mit.edu	37	12	120148383	120148383	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr12:120148383G>T	uc001txi.1	-	37	4824	c.4771C>A	c.(4771-4773)CGT>AGT	p.R1591S	CIT_uc001txh.1_Missense_Mutation_p.R1110S|CIT_uc001txj.1_Missense_Mutation_p.R1633S	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1591	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		ATGTCTAGACGGTCATCACCT	0.483		NA											46	118					1.23e-26	1.36e-26	1	0
FNDC3A	22862	broad.mit.edu	37	13	49772367	49772367	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr13:49772367A>G	uc001vcm.2	+	22	3045	c.2740A>G	c.(2740-2742)ATT>GTT	p.I914V	FNDC3A_uc001vcn.2_Missense_Mutation_p.I914V|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.I858V	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	914	Fibronectin type-III 7.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TACAAGCTATATTATCAACAA	0.363		NA											58	102					0	0	0	0
DLST	1743	broad.mit.edu	37	14	75361079	75361079	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr14:75361079C>T	uc001xqv.2	+	10	800	c.737C>T	c.(736-738)GCA>GTA	p.A246V	DLST_uc001xqu.2_Missense_Mutation_p.A158V|DLST_uc001xqt.2_Missense_Mutation_p.A162V|DLST_uc010tuw.1_Missense_Mutation_p.A160V|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.A246V	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	246					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		AATACATGTGCAATGCTGACA	0.468		NA											79	65					0	0	0	0
APBA2	321	broad.mit.edu	37	15	29346705	29346705	+	Silent	SNP	C	C	T	rs111870710	byFrequency	TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr15:29346705C>T	uc001zck.2	+	3	825	c.618C>T	c.(616-618)GGC>GGT	p.G206G	APBA2_uc010azj.2_Silent_p.G206G|APBA2_uc010uat.1_Silent_p.G206G|APBA2_uc001zcl.2_Silent_p.G206G|APBA2_uc010uas.1_Silent_p.G206G	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	206	STXBP1-binding.			DEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPY RLRR -> MSPPSLRPMTRKKMVTMCQQRGLPGLLPRGGQR EHRRLPLPPEA (in Ref. 1; AAC39767).	nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGAACACCGGCGCCTCCCCCT	0.607		NA											17	26					0	0	0	0
CLN6	54982	broad.mit.edu	37	15	68504043	68504043	+	Silent	SNP	G	G	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr15:68504043G>A	uc002arf.2	-	4	614	c.456C>T	c.(454-456)CCC>CCT	p.P152P	CLN6_uc010ujy.1_Intron|CLN6_uc010ujz.1_Silent_p.P184P	NM_017882	NP_060352	Q9NWW5	CLN6_HUMAN	CLN6 protein	152					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity				0						TCTTGATGATGGGGTTCTCAC	0.582		NA											61	154					0	0	0	0
MYO1C	4641	broad.mit.edu	37	17	1374583	1374583	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr17:1374583G>A	uc002fsp.2	-	20	2289	c.2069C>T	c.(2068-2070)CCG>CTG	p.P690L	MYO1C_uc002fsn.2_Missense_Mutation_p.P671L|MYO1C_uc002fso.2_Missense_Mutation_p.P655L|MYO1C_uc010vqj.1_Missense_Mutation_p.P655L|MYO1C_uc010vqk.1_Missense_Mutation_p.P666L	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	690	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCCATCCTGCGGCCGTCCTGC	0.667		NA											22	37					0	0	0	0
NCR1	9437	broad.mit.edu	37	19	55418074	55418074	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr19:55418074G>A	uc002qib.2	+	3	302	c.264G>A	c.(262-264)ATG>ATA	p.M88I	NCR1_uc002qic.2_Missense_Mutation_p.M88I|NCR1_uc002qie.2_Missense_Mutation_p.M88I|NCR1_uc002qid.2_Intron|NCR1_uc002qif.2_Intron|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	88	Ig-like 1.|Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TCCCGGACATGAACTCCCGCA	0.517		NA											39	74					0	0	0	0
SPTBN1	6711	broad.mit.edu	37	2	54844759	54844759	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:54844759A>G	uc002rxu.2	+	6	830	c.581A>G	c.(580-582)AAC>AGC	p.N194S	SPTBN1_uc002rxv.1_Missense_Mutation_p.N194S|SPTBN1_uc002rxx.2_Missense_Mutation_p.N181S	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	194	CH 2.|Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CCCAATGTCAACATTCACAAT	0.438		NA											19	39					0	0	0	0
THSD7B	80731	broad.mit.edu	37	2	137814582	137814582	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:137814582G>T	uc002tva.1	+	2	639	c.639G>T	c.(637-639)AAG>AAT	p.K213N	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.K103N	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTAGCCTTAAGGTTGGACCAT	0.423		NA											86	190					8.68e-40	9.78e-40	1	0
XIRP2	129446	broad.mit.edu	37	2	168106779	168106779	+	Silent	SNP	G	G	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:168106779G>A	uc002udx.2	+	8	8895	c.8877G>A	c.(8875-8877)TCG>TCA	p.S2959S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.S2784S|XIRP2_uc010fpq.2_Silent_p.S2737S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.S305S	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2784	Potential.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGATTTTGTCGAGAGTGAAAC	0.383		NA											74	135					0	0	0	0
WIPF1	7456	broad.mit.edu	37	2	175446127	175446127	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:175446127G>C	uc002uiy.2	-	4	424	c.92C>G	c.(91-93)GCT>GGT	p.A31G	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.A31G|WIPF1_uc010fqt.1_Missense_Mutation_p.A31G|WIPF1_uc002ujc.1_Missense_Mutation_p.A31G|WIPF1_uc002uiz.2_Missense_Mutation_p.A31G|WIPF1_uc002ujb.1_Missense_Mutation_p.A31G|WIPF1_uc010zep.1_Missense_Mutation_p.A31G	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	31					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						ATTTCTCCCAGCCTGCTCTGT	0.418		NA											118	198					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179401254	179401254	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr2:179401254T>C	uc010zfg.1	-	306	92740	c.92516A>G	c.(92515-92517)GAT>GGT	p.D30839G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D24534G|TTN_uc010zfi.1_Missense_Mutation_p.D24467G|TTN_uc010zfj.1_Missense_Mutation_p.D24342G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31766							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACACAAGAATCTTTTGTGAC	0.403		NA											46	92					0	0	0	0
MC3R	4159	broad.mit.edu	37	20	54824431	54824431	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr20:54824431G>C	uc002xxb.2	+	1	644	c.532G>C	c.(532-534)GTG>CTG	p.V178L		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	215	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			CTGTGGCGTGGTGTTCATCGT	0.557		NA											55	121					0	0	0	0
COL6A2	1292	broad.mit.edu	37	21	47545929	47545929	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr21:47545929C>T	uc002zia.1	+	26	2282	c.2200C>T	c.(2200-2202)CGC>TGC	p.R734C	COL6A2_uc002zhy.1_Missense_Mutation_p.R734C|COL6A2_uc002zhz.1_Missense_Mutation_p.R734C|COL6A2_uc002zib.1_Missense_Mutation_p.R140C|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	734	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CACGGACGGGCGCCACGACCC	0.637		NA											47	96					0	0	0	0
VGLL4	9686	broad.mit.edu	37	3	11600120	11600120	+	Silent	SNP	G	G	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:11600120G>A	uc003bwf.2	-	6	1149	c.783C>T	c.(781-783)AGC>AGT	p.S261S	VGLL4_uc010hdx.1_Silent_p.S267S|VGLL4_uc003bwg.2_Silent_p.S266S|VGLL4_uc010hdv.1_Silent_p.S177S|VGLL4_uc010hdw.1_Silent_p.S181S|VGLL4_uc011aun.1_Silent_p.S202S	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		ACTCAGGGCTGCTGGATGCTC	0.657		NA											33	64					0	0	0	0
ALS2CL	259173	broad.mit.edu	37	3	46725326	46725326	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:46725326G>C	uc003cqa.1	-	9	1048	c.858C>G	c.(856-858)CAC>CAG	p.H286Q	ALS2CL_uc003cpz.1_5'Flank|ALS2CL_uc003cqb.1_Missense_Mutation_p.H286Q|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	286					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GCGTGAGGAGGTGAAACGTGC	0.617		NA											65	62					0	0	0	0
PDE12	201626	broad.mit.edu	37	3	57543283	57543283	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:57543283C>T	uc003diw.3	+	1	1303	c.1177C>T	c.(1177-1179)CTT>TTT	p.L393F	PDE12_uc003div.2_Missense_Mutation_p.L393F	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	393							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TAAGTTCAGCCTTCTTAGCCA	0.532		NA											34	21					0	0	0	0
TRA2B	6434	broad.mit.edu	37	3	185655648	185655648	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr3:185655648T>C	uc003fpv.2	-	1	277	c.1A>G	c.(1-3)ATG>GTG	p.M1V	TRA2B_uc003fpu.2_5'Flank|TRA2B_uc010hym.2_5'UTR|TRA2B_uc003fpw.2_Missense_Mutation_p.M1V|TRA2B_uc003fpx.2_RNA	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	1					nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						CTGTCGCTCATGACTCCTGGC	0.632		NA											26	37					0	0	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079789	70079789	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr4:70079789G>T	uc003heh.2	-	1	661	c.652C>A	c.(652-654)CTT>ATT	p.L218I	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	218					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TCAAAATAAAGCACATAGATC	0.338		NA											31	96					4.66e-17	5.03e-17	1	0
ODZ2	57451	broad.mit.edu	37	5	167645514	167645514	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr5:167645514G>C	uc010jjd.2	+	23	4591	c.4591G>C	c.(4591-4593)GAT>CAT	p.D1531H	ODZ2_uc003lzr.3_Missense_Mutation_p.D1301H|ODZ2_uc003lzt.3_Missense_Mutation_p.D904H|ODZ2_uc010jje.2_Missense_Mutation_p.D795H	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CTACGCGACTGATGCCATCTT	0.498		NA											86	212					0	0	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179545821	179545821	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr5:179545821G>T	uc003mlq.2	-	8	1250	c.953C>A	c.(952-954)GCC>GAC	p.A318D	RASGEF1C_uc003mlr.2_Missense_Mutation_p.A318D|RASGEF1C_uc003mlp.3_Missense_Mutation_p.A167D	NM_175062	NP_778232	Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	318	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCACTTTGGCCCAGGTCTT	0.627		NA											52	87					3.17e-08	3.32e-08	1	0
KCNK16	83795	broad.mit.edu	37	6	39284101	39284101	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr6:39284101C>T	uc003ooq.2	-	5	793	c.779G>A	c.(778-780)AGA>AAA	p.R260K	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_Intron|KCNK16_uc010jwy.2_Intron|KCNK16_uc011dtz.1_Missense_Mutation_p.R260K	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	260	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						CTGGCAGCATCTGTGCAGAAG	0.637		NA											10	20					0	0	0	0
RAC1	5879	broad.mit.edu	37	7	6426860	6426860	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr7:6426860G>T	uc003spx.2	+	2	294	c.53G>T	c.(52-54)TGC>TTC	p.C18F	RAC1_uc003spw.2_Missense_Mutation_p.C18F	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	18					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GGTAAAACTTGCCTACTGATC	0.338		NA											38	115					1.16e-17	1.26e-17	1	0
DBNL	28988	broad.mit.edu	37	7	44098509	44098509	+	Silent	SNP	C	C	T	rs148365536	byFrequency	TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr7:44098509C>T	uc003tjp.3	+	9	860	c.762C>T	c.(760-762)GCC>GCT	p.A254A	DBNL_uc003tjn.2_Silent_p.A126A|DBNL_uc003tjo.3_Silent_p.A255A|DBNL_uc003tjr.3_Silent_p.A127A|DBNL_uc003tjq.3_Silent_p.A263A|DBNL_uc011kbm.1_Silent_p.A230A|DBNL_uc011kbn.1_Silent_p.A151A|DBNL_uc011kbo.1_Silent_p.A155A|DBNL_uc011kbp.1_Silent_p.A206A|DBNL_uc011kbq.1_Silent_p.A179A|DBNL_uc011kbr.1_Silent_p.A203A|DBNL_uc011kbs.1_Silent_p.A159A	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	254					activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						AGGAGTCTGCCGTGCACCCGA	0.612		NA											29	49					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94057678	94057678	+	Silent	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr7:94057678C>T	uc003ung.1	+	50	4071	c.3600C>T	c.(3598-3600)GGC>GGT	p.G1200G	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1200	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCTCTACTGGCGAAACCTGTA	0.428		NA								HNSCC(75;0.22)			65	152					0	0	0	0
ZFAND5	7763	broad.mit.edu	37	9	74975552	74975552	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr9:74975552C>T	uc004aiv.2	-	2	421	c.143G>A	c.(142-144)AGC>AAC	p.S48N	ZFAND5_uc010mox.1_5'Flank|ZFAND5_uc010moy.1_Missense_Mutation_p.S48N|ZFAND5_uc004aix.2_Missense_Mutation_p.S48N|ZFAND5_uc004aiw.2_Missense_Mutation_p.S48N|ZFAND5_uc004aiy.2_Missense_Mutation_p.S48N	NM_006007	NP_005998	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	48							DNA binding|zinc ion binding				0						ACCCATTGGGCTCATTCTGCC	0.413		NA											117	244					0	0	0	0
SH2D3C	10044	broad.mit.edu	37	9	130504111	130504111	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr9:130504111T>C	uc004bsc.2	-	9	2186	c.2044A>G	c.(2044-2046)ATG>GTG	p.M682V	SH2D3C_uc010mxo.2_Missense_Mutation_p.M522V|SH2D3C_uc004bry.2_Missense_Mutation_p.M524V|SH2D3C_uc004brz.3_Missense_Mutation_p.M328V|SH2D3C_uc011mak.1_Missense_Mutation_p.M328V|SH2D3C_uc004bsa.2_Missense_Mutation_p.M525V|SH2D3C_uc004bsb.2_Missense_Mutation_p.M614V	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	682	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						AAGCTGAACATGTTGCCCATA	0.672		NA											14	36					0	0	0	0
PTGES2	80142	broad.mit.edu	37	9	130886072	130886072	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr9:130886072C>T	uc004bti.2	-	4	1073	c.595G>A	c.(595-597)GGC>AGC	p.G199S	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.G8S|PTGES2_uc004btl.2_Missense_Mutation_p.G8S|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	199	Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						ACCTCCTTGCCCTGCTCGTTC	0.577		NA											24	70					0	0	0	0
IL3RA	3563	broad.mit.edu	37	X	1471026	1471026	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chrX:1471026C>T	uc004cps.2	+	5	681	c.332C>T	c.(331-333)ACC>ATC	p.T111I	IL3RA_uc011mhd.1_Missense_Mutation_p.T33I	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	111	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GAGAATCTGACCTGCTGGATT	0.493		NA											25	37					0	0	0	0
ZNF449	203523	broad.mit.edu	37	X	134494851	134494851	+	Silent	SNP	G	G	A			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chrX:134494851G>A	uc004eys.2	+	5	1572	c.1407G>A	c.(1405-1407)GGG>GGA	p.G469G	ZNF449_uc004eyt.2_Silent_p.G349G|ZNF449_uc004eyu.2_Silent_p.G275G	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	469	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATTATTGTGGGAAAAGTTTTA	0.388		NA											91	54					0	0	0	0
USP9Y	8287	broad.mit.edu	37	Y	14885611	14885611	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chrY:14885611C>G	uc004fst.1	+	17	3028	c.2083C>G	c.(2083-2085)CGT>GGT	p.R695G	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	695					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						TCTTTGTGATCGTGAAGCCTG	0.398		NA											76	36					0	0	0	0
TRAF3	7187	broad.mit.edu	37	14	103352585	103352585	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr14:103352585delC	uc001ymc.1	+	7	983	c.630delC	c.(628-630)GTCfs	p.V210fs	TRAF3_uc001yme.1_Frame_Shift_Del_p.V210fs|TRAF3_uc001ymd.1_Frame_Shift_Del_p.V210fs|TRAF3_uc010txy.1_Intron	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	210	TRAF-type 2.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGTGCAGCGTCCAGACTCTCC	0.498		NA											26	10	---	---	---	---	NA	NA	NA	NA
MAP2K1	5604	broad.mit.edu	37	15	66729094	66729099	+	In_Frame_Del	DEL	TGGAGA	TGGAGA	-			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr15:66729094_66729099delTGGAGA	uc010bhq.2	+	3	777_782	c.302_307delTGGAGA	c.(301-309)CTGGAGATC>CTC	p.EI102del	MAP2K1_uc010ujp.1_In_Frame_Del_p.EI80del	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	102_103	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CTAATTCATCTGGAGATCAAACCCGC	0.447		NA							Cardiofaciocutaneous_syndrome				36	60	---	---	---	---	NA	NA	NA	NA
ACOX3	8310	broad.mit.edu	37	4	8376858	8376858	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr4:8376858delC	uc010idk.2	-	15	1820	c.1675delG	c.(1675-1677)GCGfs	p.A559fs	ACOX3_uc003glc.3_Frame_Shift_Del_p.A559fs|ACOX3_uc003gld.3_Frame_Shift_Del_p.A559fs|ACOX3_uc003gle.1_Frame_Shift_Del_p.A464fs	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	559					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AAGGCCAGCGCCAACGGACGG	0.697		NA											2	4	---	---	---	---	NA	NA	NA	NA
MAS1L	116511	broad.mit.edu	37	6	29455156	29455157	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr6:29455156_29455157delAC	uc011dlq.1	-	1	523_524	c.523_524delGT	c.(523-525)GTCfs	p.V175fs		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	175	Cytoplasmic (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						GGGGAAGAGGACACACACACAC	0.495		NA											9	124	---	---	---	---	NA	NA	NA	NA
CSMD3	114788	broad.mit.edu	37	8	113332168	113332168	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-5250-01A-01D-1512-08	TCGA-CR-5250-10A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	49e54f5a-9b3a-47ff-b6cc-a1eaf54fd136	79557539-56d8-411f-8151-1bc33fe25c4d	g.chr8:113332168delT	uc003ynu.2	-	46	7367	c.7208delA	c.(7207-7209)AATfs	p.N2403fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.N1605fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.N2363fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.N2299fs|CSMD3_uc003ynw.1_Frame_Shift_Del_p.N114fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2403	Extracellular (Potential).|Sushi 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATTTCAGCATTGGGCACAGG	0.353		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			53	155	---	---	---	---	NA	NA	NA	NA