Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
KLHL17	339451	broad.mit.edu	37	1	898584	898584	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:898584G>T	uc001aca.1	+	7	1245	c.1138G>T	c.(1138-1140)GCC>TCC	p.A380S	KLHL17_uc001acc.1_RNA|KLHL17_uc010nyb.1_Silent_p.G128G	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	380	Interaction with F-actin (By similarity).|Kelch 1.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACGCGCCGGGCCCGGGTGGG	0.716		NA											4	13					0.00024832	0.000264201	1	0
WDTC1	23038	broad.mit.edu	37	1	27632707	27632707	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:27632707G>A	uc009vst.2	+	16	2402	c.1867G>A	c.(1867-1869)GAT>AAT	p.D623N	WDTC1_uc001bno.2_Missense_Mutation_p.D622N|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Missense_Mutation_p.D301N	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	623							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		AGTCGTGGAAGATATGGAGGG	0.607		NA											19	36					0	0	0	0
KPRP	448834	broad.mit.edu	37	1	152732235	152732235	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr1:152732235C>T	uc001fal.1	+	2	229	c.171C>T	c.(169-171)TGC>TGT	p.C57C		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	57	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCAAGTTTGCCAGGTGTCAG	0.547		NA											30	79					0	0	0	0
MTPAP	55149	broad.mit.edu	37	10	30638194	30638194	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr10:30638194G>A	uc001iva.3	-	1	74	c.11C>T	c.(10-12)CCC>CTC	p.P4L	MTPAP_uc001ivb.3_Intron|MTPAP_uc001ivc.2_Missense_Mutation_p.P4L	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	4					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						CCCCACGCCGGGAACCGCCAT	0.567		NA											3	31					0	0	0	0
TACC2	10579	broad.mit.edu	37	10	123989891	123989891	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr10:123989891G>A	uc001lfv.2	+	16	8423	c.8063G>A	c.(8062-8064)CGG>CAG	p.R2688Q	TACC2_uc001lfw.2_Missense_Mutation_p.R834Q|TACC2_uc009xzx.2_Intron|TACC2_uc010qtv.1_Intron|TACC2_uc001lfx.2_Intron|TACC2_uc001lfy.2_Intron|TACC2_uc001lfz.2_Missense_Mutation_p.R766Q|TACC2_uc001lga.2_Intron|TACC2_uc009xzy.2_Intron|TACC2_uc001lgb.2_Intron	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2688	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCCATCATGCGGATAGAAGCC	0.567		NA											35	93					0	0	0	0
ILK	3611	broad.mit.edu	37	11	6630568	6630568	+	Silent	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr11:6630568G>A	uc001mee.2	+	8	792	c.657G>A	c.(655-657)GTG>GTA	p.V219V	ILK_uc001mef.2_Silent_p.V219V|ILK_uc010rap.1_Silent_p.V85V|ILK_uc010raq.1_Silent_p.V158V|ILK_uc001meg.2_Silent_p.V65V|ILK_uc001meh.2_Silent_p.V219V|ILK_uc001mei.2_5'Flank	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	219	Protein kinase.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		ACATTGTCGTGAAGGTGCTGA	0.547		NA											24	57					0	0	0	0
CKAP5	9793	broad.mit.edu	37	11	46800015	46800015	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr11:46800015C>G	uc001ndi.1	-	21	2678	c.2568G>C	c.(2566-2568)GAG>GAC	p.E856D	CKAP5_uc009ylg.1_Missense_Mutation_p.E742D|CKAP5_uc001ndj.1_Missense_Mutation_p.E856D	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	856	HEAT 5.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CCTACCTGATCTCCGTCCTCG	0.413		NA											23	54					0	0	0	0
AKAP3	10566	broad.mit.edu	37	12	4735774	4735774	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:4735774G>A	uc001qnb.3	-	4	2523	c.2294C>T	c.(2293-2295)ACG>ATG	p.T765M		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	765					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						AACTGTGTCCGTTAGGTTGTG	0.488		NA											30	126					0	0	0	0
KRT6B	3854	broad.mit.edu	37	12	52843354	52843354	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr12:52843354G>A	uc001sak.2	-	5	1024	c.976C>T	c.(976-978)CGC>TGC	p.R326C		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	326	Rod.|Linker 12.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		TCCAGGTTGCGGTTGTTGTCC	0.527		NA											4	220					0	0	0	0
PCDH8	5100	broad.mit.edu	37	13	53420242	53420242	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr13:53420242C>T	uc001vhi.2	-	1	2533	c.2330G>A	c.(2329-2331)CGC>CAC	p.R777H	PCDH8_uc001vhj.2_Missense_Mutation_p.R777H	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	777	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCCTTCTTGCGGCGGTTGCA	0.622		NA											15	17					0	0	0	0
GPC5	2262	broad.mit.edu	37	13	92345950	92345950	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr13:92345950C>T	uc010tif.1	+	3	1201	c.835C>T	c.(835-837)CGA>TGA	p.R279*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	279						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CAATGTCATGCGAGGCTGCCT	0.542		NA											22	27					0	0	0	0
FSCB	84075	broad.mit.edu	37	14	44974032	44974032	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr14:44974032G>A	uc001wvn.2	-	1	2468	c.2159C>T	c.(2158-2160)CCA>CTA	p.P720L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	720						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CAAATCAGCTGGTGGGGAATG	0.522		NA											11	30					0	0	0	0
RPL4	6124	broad.mit.edu	37	15	66795855	66795855	+	Missense_Mutation	SNP	G	G	A	rs142487012		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr15:66795855G>A	uc002apv.2	-	2	72	c.16C>T	c.(16-18)CCA>TCA	p.P6S	RPL4_uc010bhr.2_5'UTR|RPL4_uc002apw.2_5'UTR|RPL4_uc002apx.2_5'UTR|RPL4_uc010ujq.1_Missense_Mutation_p.P6S|SNORD18C_uc010bhs.1_5'Flank|SNORD18B_uc002apy.1_5'Flank|SNORD16_uc010bht.2_5'Flank|SNORD18A_uc002apz.1_5'Flank|ZWILCH_uc010bhu.1_5'Flank|ZWILCH_uc002aqb.2_5'Flank|ZWILCH_uc002aqa.2_5'Flank|ZWILCH_uc010bhv.2_5'Flank	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	6					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						GATATCAGTGGGCGAGCACAC	0.403		NA											26	11					0	0	0	0
XYLT1	64131	broad.mit.edu	37	16	17202658	17202658	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr16:17202658G>C	uc002dfa.2	-	12	2859	c.2774C>G	c.(2773-2775)ACA>AGA	p.T925R		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	925	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CGGGCAGGCTGTGGGGCCCGT	0.677		NA											9	19					0	0	0	0
GLOD4	51031	broad.mit.edu	37	17	685428	685428	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:685428T>C	uc002frv.2	-	1	144	c.68A>G	c.(67-69)TAT>TGT	p.Y23C	GLOD4_uc002fru.2_Missense_Mutation_p.Y23C|GLOD4_uc010vqc.1_5'UTR|RNMTL1_uc002frw.2_5'Flank	NM_016080	NP_057164	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	23						mitochondrion					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		GACGTCCCGATAGAAACGCGC	0.692		NA											13	32					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7668743	7668743	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:7668743G>A	uc002giu.1	+	20	3385	c.3371G>A	c.(3370-3372)TGG>TAG	p.W1124*		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1124	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACGGGGAGTGGGTTGTCTTC	0.537		NA											28	74					0	0	0	0
DHX58	79132	broad.mit.edu	37	17	40253880	40253880	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:40253880G>A	uc002hyw.3	-	14	2159	c.1936C>T	c.(1936-1938)CGG>TGG	p.R646W	DHX58_uc002hyv.3_RNA	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	646	RNA-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GCCTGGATCCGCCCCTGAGGG	0.587		NA									OREG0024418	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	68					0	0	0	0
SPOP	8405	broad.mit.edu	37	17	47688665	47688665	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:47688665T>C	uc010dbk.2	-	7	1267	c.635A>G	c.(634-636)CAG>CGG	p.Q212R	SPOP_uc002ipb.2_Missense_Mutation_p.Q212R|SPOP_uc002ipc.2_Missense_Mutation_p.Q212R|SPOP_uc002ipd.2_Missense_Mutation_p.Q212R|SPOP_uc002ipe.2_Missense_Mutation_p.Q212R|SPOP_uc002ipf.2_Missense_Mutation_p.Q212R|SPOP_uc002ipg.2_Missense_Mutation_p.Q212R	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	212	BTB.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CTTGTGAGCCTGGAATTCCTG	0.448		NA								Prostate(2;0.17)			4	201					0	0	0	0
ITGB4	3691	broad.mit.edu	37	17	73753345	73753345	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:73753345C>T	uc002jpg.2	+	39	5470	c.5283C>T	c.(5281-5283)AGC>AGT	p.S1761S	ITGB4_uc002jph.2_Silent_p.S1691S|ITGB4_uc002jpi.3_Silent_p.S1691S|ITGB4_uc002jpj.2_Silent_p.S1744S|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1761	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCGAGTACAGCAGCATCACCA	0.667		NA											16	37					0	0	0	0
C18orf34	374864	broad.mit.edu	37	18	30969508	30969508	+	Silent	SNP	A	A	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr18:30969508A>C	uc002kxn.2	-	4	346	c.204T>G	c.(202-204)ACT>ACG	p.T68T	C18orf34_uc010xbr.1_Silent_p.T68T|C18orf34_uc010dmf.1_Silent_p.T68T|C18orf34_uc002kxo.2_Silent_p.T68T|C18orf34_uc002kxp.2_Silent_p.T68T	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	68										ovary(1)	1						CCTCACCTTCAGTATTTGTCA	0.279		NA											19	43					0	0	0	0
ATP5A1	498	broad.mit.edu	37	18	43666161	43666161	+	Silent	SNP	G	G	A	rs141613719		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr18:43666161G>A	uc002lbr.1	-	10	1437	c.1347C>T	c.(1345-1347)TTC>TTT	p.F449F	ATP5A1_uc010dnl.1_Silent_p.F399F|ATP5A1_uc002lbs.1_Silent_p.F399F|ATP5A1_uc002lbt.1_Silent_p.F449F	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	449					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						GGTCAGAACCGAACTGGGCAA	0.458		NA											51	44					0	0	0	0
APBA3	9546	broad.mit.edu	37	19	3752701	3752701	+	Silent	SNP	C	C	G			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:3752701C>G	uc002lyp.1	-	8	1377	c.1200G>C	c.(1198-1200)CGG>CGC	p.R400R	APBA3_uc002lyo.1_Silent_p.R158R	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	400	PDZ 1.				intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCCCTCGCCGCTTCTCGA	0.746		NA											6	8					0	0	0	0
DPP9	91039	broad.mit.edu	37	19	4684712	4684712	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:4684712C>A	uc002mba.2	-	18	2399	c.2141G>T	c.(2140-2142)CGA>CTA	p.R714L		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	685					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CCGAAGCCCTCGCTGACAGGA	0.582		NA											7	15					1.26e-09	1.41e-09	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56703238	56703238	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr19:56703238G>C	uc010ygh.1	-	2	569	c.569C>G	c.(568-570)GCT>GGT	p.A190G		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	190					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGACAGTGCAGCGACCCTGGG	0.622		NA											6	31					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141267498	141267498	+	Silent	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:141267498G>A	uc002tvj.1	-	52	9369	c.8397C>T	c.(8395-8397)TGC>TGT	p.C2799C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2799	Extracellular (Potential).|LDL-receptor class A 17.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTTCATACCGCAGCCTGCTG	0.507		NA								TSP Lung(27;0.18)			4	110					0	0	0	0
OBSL1	23363	broad.mit.edu	37	2	220435109	220435109	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:220435109C>T	uc010fwk.2	-	1	903	c.846G>A	c.(844-846)GAG>GAA	p.E282E	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Silent_p.E282E|OBSL1_uc002vmj.2_Intron|INHA_uc002vmk.1_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	282	Ig-like 3.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GCGGGCGGCCCTCCCAGTGCC	0.672		NA											10	20					0	0	0	0
KIF1A	547	broad.mit.edu	37	2	241722504	241722504	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr2:241722504G>A	uc002vzy.2	-	9	967	c.821C>T	c.(820-822)TCG>TTG	p.S274L	KIF1A_uc010fzk.2_Missense_Mutation_p.S274L|KIF1A_uc002vzz.1_Missense_Mutation_p.S274L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	274	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GGTGGTCAGCGACTTGTTGAT	0.657		NA											24	40					0	0	0	0
C20orf160	140706	broad.mit.edu	37	20	30617557	30617557	+	Silent	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:30617557G>A	uc002wxf.2	+	8	1267	c.1254G>A	c.(1252-1254)GGG>GGA	p.G418G	C20orf160_uc002wxg.2_Missense_Mutation_p.E22K	NM_080625	NP_542192	Q9NUG4	CT160_HUMAN	hypothetical protein LOC140706	Error:Variant_position_missing_in_Q9NUG4_after_alignment										central_nervous_system(3)|ovary(1)	4						GCTGCTGCGGGAGTACCGGCT	0.617		NA											11	54					0	0	0	0
DSN1	79980	broad.mit.edu	37	20	35399490	35399490	+	Silent	SNP	G	G	A	rs139234953		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:35399490G>A	uc010gfr.2	-	3	514	c.141C>T	c.(139-141)GGC>GGT	p.G47G	DSN1_uc002xfz.2_Silent_p.G47G|DSN1_uc002xfy.3_Intron|DSN1_uc002xga.2_Silent_p.G47G|DSN1_uc010zvs.1_Intron|DSN1_uc002xgc.2_Silent_p.G31G|DSN1_uc002xgb.2_Silent_p.G31G	NM_001145316	NP_001138788	Q9H410	DSN1_HUMAN	DSN1, MIND kinetochore complex component,	47					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)				CCTCTGAAACGCCTTGATTCA	0.448		NA											53	205					0	0	0	0
MC3R	4159	broad.mit.edu	37	20	54823948	54823948	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr20:54823948G>A	uc002xxb.2	+	1	161	c.49G>A	c.(49-51)GGC>AGC	p.G17S		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	54	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			ACTGCCTAATGGCTCGGAGCA	0.582		NA											56	153					0	0	0	0
LSS	4047	broad.mit.edu	37	21	47626627	47626627	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr21:47626627C>T	uc002zij.2	-	16	1602	c.1523G>A	c.(1522-1524)GGG>GAG	p.G508E	LSS_uc011afv.1_Missense_Mutation_p.G497E|LSS_uc002zil.2_Missense_Mutation_p.G508E|LSS_uc002zik.2_Missense_Mutation_p.G428E	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	508	PFTB 2.				cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					CAAGTGCCCCCCACGCTTGGT	0.602		NA											20	56					0	0	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458538	20458538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr22:20458538G>A	uc002zsd.3	-	1	3249	c.2764C>T	c.(2764-2766)CAG>TAG	p.Q922*		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			GCTTCATCCTGCCCCGCTGGG	0.597		NA											10	34					0	0	0	0
SLC4A7	9497	broad.mit.edu	37	3	27431585	27431585	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr3:27431585C>T	uc003cdv.2	-	22	3241	c.3170G>A	c.(3169-3171)CGT>CAT	p.R1057H	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.R938H|SLC4A7_uc011aww.1_Missense_Mutation_p.R1066H|SLC4A7_uc011awx.1_Missense_Mutation_p.R1053H|SLC4A7_uc011awy.1_Missense_Mutation_p.R1049H|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.R938H|SLC4A7_uc011axb.1_Missense_Mutation_p.R1053H|SLC4A7_uc010hfl.2_Missense_Mutation_p.R607H|SLC4A7_uc003cdw.2_Missense_Mutation_p.R933H	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	1057	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						TAATTTTATACGGTCAAATAA	0.328		NA											4	163					0	0	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25314436	25314436	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:25314436C>T	uc003grl.3	+	1	41	c.5C>T	c.(4-6)GCG>GTG	p.A2V		NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	2							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				GGGAAGATGGCGGCCTCCAGG	0.652		NA									OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	174					0	0	0	0
NAA11	84779	broad.mit.edu	37	4	80247011	80247011	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:80247011C>T	uc003hlt.3	-	1	161	c.21G>A	c.(19-21)CAG>CAA	p.Q7Q		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	7	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						GGTCGTCTGGCTGAGCGTTGC	0.522		NA											15	25					0	0	0	0
EGF	1950	broad.mit.edu	37	4	110915936	110915936	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:110915936G>A	uc003hzy.3	+	20	3357	c.2905G>A	c.(2905-2907)GTA>ATA	p.V969I	EGF_uc011cfu.1_Missense_Mutation_p.V927I|EGF_uc011cfv.1_Missense_Mutation_p.V928I|EGF_uc010imk.2_Missense_Mutation_p.V117I	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	969	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CCACTATTCCGTAAGAAATAG	0.443		NA											27	47					0	0	0	0
C4orf31	79625	broad.mit.edu	37	4	121957686	121957686	+	Silent	SNP	G	G	A	rs146653001		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:121957686G>A	uc003idq.1	-	4	1967	c.1440C>T	c.(1438-1440)ATC>ATT	p.I480I		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	480	Fibronectin type-III 2.										0						CTTTTTTGTAGATGCAAAACT	0.433		NA											24	67					0	0	0	0
TBC1D9	23158	broad.mit.edu	37	4	141583131	141583131	+	Silent	SNP	A	A	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:141583131A>T	uc010ioj.2	-	10	1991	c.1719T>A	c.(1717-1719)GCT>GCA	p.A573A		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	573	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CATTCTGAAAAGCTGGGTGTT	0.468		NA											24	58					0	0	0	0
FAM149A	25854	broad.mit.edu	37	4	187074901	187074901	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr4:187074901C>T	uc003iyt.3	+	5	768	c.189C>T	c.(187-189)TGC>TGT	p.C63C	FAM149A_uc011cla.1_Silent_p.C63C|FAM149A_uc010isj.2_Silent_p.C63C|FAM149A_uc010isk.2_RNA|FAM149A_uc003iyu.3_Silent_p.C63C|FAM149A_uc010isl.2_Silent_p.C63C|FAM149A_uc011clb.1_Silent_p.C63C	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	354										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TCAGTGCCTGCGGACACAGCA	0.468		NA											4	174					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89943471	89943471	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr5:89943471C>T	uc003kju.2	+	17	3275	c.3179C>T	c.(3178-3180)ACG>ATG	p.T1060M	GPR98_uc003kjt.2_Translation_Start_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1060	Calx-beta 8.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAGGAGAAACGCTCATTTTT	0.413		NA											33	139					0	0	0	0
TCERG1	10915	broad.mit.edu	37	5	145851099	145851099	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr5:145851099G>A	uc003lob.2	+	9	1601	c.1561G>A	c.(1561-1563)GCA>ACA	p.A521T	TCERG1_uc003loc.2_Missense_Mutation_p.A500T|TCERG1_uc011dbt.1_Missense_Mutation_p.A500T	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	521					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGCCCAGAAGGCAAAGCCAGT	0.333		NA											74	67					0	0	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571952	30571952	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:30571952C>T	uc003nqn.1	-	14	1893	c.1341G>A	c.(1339-1341)GCG>GCA	p.A447A	PPP1R10_uc010jsc.1_Silent_p.A101A	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	447	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TCAGACGCCGCGCTGTCTCAA	0.552		NA											109	45					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152651634	152651634	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:152651634G>A	uc010kiw.2	-	78	14788	c.14186C>T	c.(14185-14187)GCG>GTG	p.A4729V	SYNE1_uc003qot.3_Missense_Mutation_p.A4658V|SYNE1_uc003qou.3_Missense_Mutation_p.A4729V|SYNE1_uc010kiz.2_Missense_Mutation_p.A484V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4729	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCATCCACCGCCTCCCCAAG	0.552		NA								HNSCC(10;0.0054)			14	42					0	0	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6077066	6077066	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:6077066G>A	uc003spp.2	-	11	1467	c.1321C>T	c.(1321-1323)CGA>TGA	p.R441*	EIF2AK1_uc003spq.2_Nonsense_Mutation_p.R440*|EIF2AK1_uc011jwm.1_Nonsense_Mutation_p.R317*	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	441	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TTCAGATCTCGGTGCACAATT	0.378		NA											32	45					0	0	0	0
EEPD1	80820	broad.mit.edu	37	7	36194642	36194642	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:36194642G>A	uc003tfa.2	+	2	1349	c.709G>A	c.(709-711)GGG>AGG	p.G237R		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	237					DNA repair		DNA binding				0						GCCGCCAGGGGGGCCCACCCA	0.662		NA											8	28					0	0	0	0
POM121L12	285877	broad.mit.edu	37	7	53103445	53103445	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr7:53103445C>T	uc003tpz.2	+	1	97	c.81C>T	c.(79-81)GAC>GAT	p.D27D		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	27											0						AAGGCCCCGACGCCCTGGCGG	0.701		NA											7	13					0	0	0	0
XPO7	23039	broad.mit.edu	37	8	21851879	21851879	+	Silent	SNP	T	T	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:21851879T>A	uc003xaa.3	+	20	2256	c.2154T>A	c.(2152-2154)ACT>ACA	p.T718T	XPO7_uc010lti.2_Silent_p.T727T|XPO7_uc010ltk.2_Silent_p.T719T	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	718					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		TACAGCGAACTCTAGTTGGCC	0.388		NA											18	35					0	0	0	0
ASH2L	9070	broad.mit.edu	37	8	37986388	37986388	+	Silent	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:37986388G>A	uc003xkt.3	+	12	1504	c.1446G>A	c.(1444-1446)CAG>CAA	p.Q482Q	ASH2L_uc011lbk.1_Silent_p.Q343Q|ASH2L_uc003xku.3_Silent_p.Q388Q|ASH2L_uc010lwa.2_Silent_p.Q388Q	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	482	B30.2/SPRY.				hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				GCTATGGACAGGGAGACGTCC	0.443		NA											108	487					0	0	0	0
PDE7A	5150	broad.mit.edu	37	8	66695027	66695027	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:66695027G>A	uc003xvq.2	-	2	202	c.190C>T	c.(190-192)CGT>TGT	p.R64C	PDE7A_uc003xvr.2_Missense_Mutation_p.R64C|PDE7A_uc003xvp.2_Missense_Mutation_p.R38C	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	64						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	CCTAGCATACGAATGTATAAT	0.284		NA											11	15					0	0	0	0
ZHX2	22882	broad.mit.edu	37	8	123966105	123966105	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr8:123966105C>T	uc003ypk.1	+	3	2922	c.2355C>T	c.(2353-2355)AAC>AAT	p.N785N		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	785						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GCGACGAGAACGAGGAGTCGA	0.612		NA											9	31					0	0	0	0
SLC24A2	25769	broad.mit.edu	37	9	19619581	19619581	+	Splice_Site	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:19619581C>T	uc003zoa.1	-	3	1140	c.1078_splice	c.e3+1	p.E360_splice	SLC24A2_uc003zob.1_Splice_Site_p.G360_splice	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24						visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TTGATGTTTACCTTCGGCGAG	0.512		NA											46	155					0	0	0	0
C9orf23	138716	broad.mit.edu	37	9	34610878	34610878	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:34610878G>C	uc003zuu.2	-	2	697	c.416C>G	c.(415-417)CCC>CGC	p.P139R	C9orf23_uc003zuv.2_Missense_Mutation_p.P139R	NM_148179	NP_680545	Q8N5L8	CI023_HUMAN	hypothetical protein LOC138716	139							nucleic acid binding				0	all_epithelial(49;0.0863)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.0385)		CAGGCCAGGGGGTGCTCCTGG	0.657		NA											26	65					0	0	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128347842	128347842	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:128347842C>T	uc004bpv.2	-	5	996	c.663G>A	c.(661-663)CCG>CCA	p.P221P	MAPKAP1_uc011lzt.1_Silent_p.P24P|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Silent_p.P24P|MAPKAP1_uc011lzv.1_Silent_p.P24P|MAPKAP1_uc004bpw.2_Silent_p.P29P|MAPKAP1_uc004bpx.2_Silent_p.P29P|MAPKAP1_uc004bpy.2_Silent_p.P221P|MAPKAP1_uc004bpz.2_Silent_p.P221P|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc010mxb.1_Silent_p.P24P|MAPKAP1_uc004bqa.2_Silent_p.P221P|MAPKAP1_uc010mxc.1_Silent_p.P93P	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	221					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						ACTTGAGCTTCGGCTCCCGTC	0.532		NA											26	111					0	0	0	0
BAT2L1	84726	broad.mit.edu	37	9	134367624	134367624	+	Silent	SNP	C	C	T			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr9:134367624C>T	uc004can.3	+	29	6505	c.6450C>T	c.(6448-6450)CCC>CCT	p.P2150P	BAT2L1_uc004cao.3_Silent_p.P1507P|BAT2L1_uc004cap.3_Silent_p.P296P|BAT2L1_uc011mch.1_Silent_p.P73P	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	2150							protein binding				0						CAGGAGGCCCCGTGCCATCGC	0.552		NA											15	88					0	0	0	0
EPN2	22905	broad.mit.edu	37	17	19232949	19232950	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:19232949_19232950insA	uc002gvd.3	+	9	1848_1849	c.1400_1401insA	c.(1399-1401)TCAfs	p.S467fs	EPN2_uc010cql.1_Frame_Shift_Ins_p.S176fs|EPN2_uc002gve.3_Frame_Shift_Ins_p.S410fs|EPN2_uc002gvf.3_Frame_Shift_Ins_p.S182fs|EPN2_uc010vyo.1_Frame_Shift_Ins_p.S175fs|EPN2_uc010vyp.1_Frame_Shift_Ins_p.S403fs|EPN2_uc010vyq.1_Frame_Shift_Ins_p.S404fs|EPN2_uc002gvh.1_Frame_Shift_Ins_p.S467fs|EPN2_uc002gvj.3_Frame_Shift_Ins_p.S130fs	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	467	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CTTCGGACTTCAAAAAAAACAG	0.396		NA											7	139	---	---	---	---	NA	NA	NA	NA
TBC1D3B	414059	broad.mit.edu	37	17	34499240	34499240	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr17:34499240delC	uc002hky.2	-	7	621	c.471delG	c.(469-471)ATGfs	p.M157fs	uc002hla.1_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	157	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCCTGAAGAACATATGCTTCC	0.562		NA											48	1435	---	---	---	---	NA	NA	NA	NA
HLA-A	3105	broad.mit.edu	37	6	29911160	29911179	+	Frame_Shift_Del	DEL	CCTGCGCTCTTGGACCGCGG	CCTGCGCTCTTGGACCGCGG	-	rs41552413		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:29911160_29911179delCCTGCGCTCTTGGACCGCGG	uc003nol.2	+	3	459_478	c.459_478delCCTGCGCTCTTGGACCGCGG	c.(457-480)GACCTGCGCTCTTGGACCGCGGCGfs	p.D153fs	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_RNA|HLA-A_uc010jrq.2_Frame_Shift_Del_p.D32fs|HLA-A_uc003nok.2_Frame_Shift_Del_p.D32fs|HLA-A_uc003non.2_Frame_Shift_Del_p.D153fs|HLA-A_uc003noo.2_Frame_Shift_Del_p.D153fs|HLA-A_uc010jrr.2_Frame_Shift_Del_p.D153fs|HLA-A_uc003nom.2_Frame_Shift_Del_p.D32fs|HLA-A_uc010klp.2_Frame_Shift_Del_p.D125fs|HLA-A_uc011dmc.1_Frame_Shift_Del_p.D32fs|HLA-A_uc011dmd.1_Frame_Shift_Del_p.D32fs	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	153_160	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGAACGAGGACCTGCGCTCTTGGACCGCGGCGGACATGGC	0.655		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			14	25	---	---	---	---	NA	NA	NA	NA
TTLL2	83887	broad.mit.edu	37	6	167754366	167754367	+	Frame_Shift_Ins	INS	-	-	T	rs150247166		TCGA-CR-6467-01A-11D-1870-08	TCGA-CR-6467-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	2a7f5a16-9330-45a1-9024-1cff1cdb5714	85fe30a5-dc3c-47fc-8e86-33aa839416d4	g.chr6:167754366_167754367insT	uc003qvs.1	+	3	1066_1067	c.978_979insT	c.(976-981)AGATTTfs	p.R326fs	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	326_327	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CGCTCAGCAGATTTTTTTCCTA	0.446		NA											82	161	---	---	---	---	NA	NA	NA	NA