Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418		NA											6	70					0	0	0	0
LAPTM5	7805	broad.mit.edu	37	1	31212769	31212769	+	Silent	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:31212769G>A	uc001bsc.2	-	4	365	c.274C>T	c.(274-276)CTG>TTG	p.L92L		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	92	Helical; (Potential).				transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGGCAGCAGGTACTTCTCC	0.592		NA											9	17					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39749133	39749133	+	Silent	SNP	G	G	A	rs150686066		TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:39749133G>A	uc010ois.1	+	10	1081	c.876G>A	c.(874-876)TCG>TCA	p.S292S	MACF1_uc001cda.1_Silent_p.S200S	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	292	Actin-binding.|CH 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATGTGTCTTCGATTTATGATG	0.408		NA											16	48					0	0	0	0
CYP4A22	284541	broad.mit.edu	37	1	47609516	47609516	+	Missense_Mutation	SNP	G	G	A	rs143425502	byFrequency	TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:47609516G>A	uc001cqv.1	+	6	769	c.718G>A	c.(718-720)GAC>AAC	p.D240N	CYP4A22_uc009vyo.2_Missense_Mutation_p.D240N|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	240						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						TCATGAGAATGACACCATCTA	0.537		NA											31	87					0	0	0	0
SLC44A5	204962	broad.mit.edu	37	1	75685020	75685020	+	Silent	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:75685020C>T	uc001dgu.2	-	16	1332	c.1188G>A	c.(1186-1188)GCG>GCA	p.A396A	SLC44A5_uc001dgt.2_Silent_p.A396A|SLC44A5_uc001dgs.2_Silent_p.A354A|SLC44A5_uc001dgr.2_Silent_p.A354A|SLC44A5_uc010oqz.1_Silent_p.A435A|SLC44A5_uc010ora.1_Silent_p.A390A|SLC44A5_uc010orb.1_Silent_p.A266A	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	396	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						CCCCCGATGTCGCCAAGAAAC	0.393		NA											6	33					0	0	0	0
BCAR3	8412	broad.mit.edu	37	1	94140372	94140372	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:94140372G>A	uc001dpz.2	-	2	390	c.115C>T	c.(115-117)CCA>TCA	p.P39S	BCAR3_uc001dqa.2_Missense_Mutation_p.P39S|BCAR3_uc001dqb.2_Missense_Mutation_p.P39S	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	39					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TAGGCATCTGGGCGATGCTCA	0.537		NA											9	49					0	0	0	0
FNDC7	163479	broad.mit.edu	37	1	109271297	109271297	+	Silent	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:109271297C>T	uc001dvx.2	+	8	1413	c.1413C>T	c.(1411-1413)TTC>TTT	p.F471F	FNDC7_uc010ova.1_Silent_p.F238F	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	472	Fibronectin type-III 6.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GGGATGCATTCTCCATGATTA	0.428		NA											14	59					0	0	0	0
C1orf107	27042	broad.mit.edu	37	1	210024731	210024731	+	Missense_Mutation	SNP	G	G	A	rs141651647	by1000genomes	TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:210024731G>A	uc001hhr.1	+	12	2286	c.2210G>A	c.(2209-2211)CGG>CAG	p.R737Q	C1orf107_uc009xcu.1_Missense_Mutation_p.R452Q	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	737					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GGTGTGGAGCGGGCGGCACAG	0.498		NA											11	38					0	0	0	0
NID1	4811	broad.mit.edu	37	1	236195924	236195924	+	Silent	SNP	C	C	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:236195924C>A	uc001hxo.2	-	6	1416	c.1314G>T	c.(1312-1314)GTG>GTT	p.V438V	NID1_uc009xgd.2_Silent_p.V438V	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	438	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCCTTCCTTTCACCTTGCCAT	0.478		NA											9	40					1.13e-05	1.27e-05	1	0
HEATR1	55127	broad.mit.edu	37	1	236766584	236766584	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:236766584G>A	uc001hyd.1	-	3	360	c.235C>T	c.(235-237)CGA>TGA	p.R79*	HEATR1_uc001hye.1_Nonsense_Mutation_p.R79*	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	79					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGAACACTTCGCTCCAAGGTT	0.418		NA											11	64					0	0	0	0
SVIL	6840	broad.mit.edu	37	10	29801693	29801693	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr10:29801693G>A	uc001iut.1	-	17	4240	c.3487C>T	c.(3487-3489)CAG>TAG	p.Q1163*	SVIL_uc010qdw.1_Nonsense_Mutation_p.Q61*|SVIL_uc001iuu.1_Nonsense_Mutation_p.Q737*	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1163					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CCTGCTTCCTGGGTGTGCAGG	0.542		NA									OREG0020097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	67					0	0	0	0
NRP1	8829	broad.mit.edu	37	10	33474639	33474639	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr10:33474639C>T	uc001iwx.3	-	15	2871	c.2348G>A	c.(2347-2349)GGC>GAC	p.G783D	NRP1_uc001iwv.3_Missense_Mutation_p.G783D|NRP1_uc009xlz.2_Missense_Mutation_p.G777D|NRP1_uc001iww.3_Missense_Mutation_p.G595D|NRP1_uc001iwy.3_Missense_Mutation_p.G776D	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	783	Extracellular (Potential).|MAM.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	TCCGATTTCGCCCTCGAAAAT	0.403		NA											3	43					0	0	0	0
FAM53B	9679	broad.mit.edu	37	10	126312097	126312097	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr10:126312097C>T	uc001lhv.1	-	5	1506	c.983G>A	c.(982-984)CGC>CAC	p.R328H	FAM53B_uc001lhu.1_Intron	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	328										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		GCTGACGTGGCGGGCGAAGGG	0.697		NA											7	5					0	0	0	0
SLC25A22	79751	broad.mit.edu	37	11	792587	792587	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr11:792587C>T	uc001lri.2	-	7	895	c.553G>A	c.(553-555)GGT>AGT	p.G185S	CEND1_uc001lrh.1_5'Flank|SLC25A22_uc009yci.2_Missense_Mutation_p.G185S|SLC25A22_uc001lrj.2_Missense_Mutation_p.G185S	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	185	Solcar 2.					integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	TTGTAGAGACCGGCAATGCCA	0.736		NA											7	18					0	0	0	0
PTPRJ	5795	broad.mit.edu	37	11	48145371	48145371	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr11:48145371C>G	uc001ngp.3	+	5	1178	c.823C>G	c.(823-825)CTA>GTA	p.L275V	PTPRJ_uc001ngo.3_Missense_Mutation_p.L275V	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	275	Extracellular (Potential).|Fibronectin type-III 2.|Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CCCGTATCTTCTACAATCAAA	0.473		NA											24	63					0	0	0	0
SPTBN2	6712	broad.mit.edu	37	11	66457726	66457726	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr11:66457726C>T	uc001ojd.2	-	27	5666	c.5594G>A	c.(5593-5595)CGG>CAG	p.R1865Q	SPTBN2_uc001ojc.1_5'Flank	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1865	Spectrin 15.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CTTCTGGAGCCGGTGGCCGTC	0.701		NA											5	10					0	0	0	0
ERC1	23085	broad.mit.edu	37	12	1553834	1553834	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr12:1553834G>A	uc001qjb.2	+	18	3372	c.3131G>A	c.(3130-3132)GGA>GAA	p.G1044E	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.G1016E|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.G1044E|ERC1_uc010sdv.1_3'UTR|ERC1_uc001qje.2_RNA	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	1044					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			ATCCTCCGTGGACTCACTCCA	0.522		NA											29	95					0	0	0	0
CTDSP2	10106	broad.mit.edu	37	12	58217826	58217826	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr12:58217826C>T	uc001sqm.2	-	7	1080	c.551G>A	c.(550-552)CGG>CAG	p.R184Q	CTDSP2_uc010ssg.1_Missense_Mutation_p.R58Q|CTDSP2_uc009zqf.2_Missense_Mutation_p.R32Q|CTDSP2_uc009zqg.2_Intron	NM_005730	NP_005721	O14595	CTDS2_HUMAN	nuclear LIM interactor-interacting factor 2	184	FCP1 homology.				protein dephosphorylation	nucleus|soluble fraction	CTD phosphatase activity|metal ion binding			central_nervous_system(1)	1	all_neural(12;0.00559)|Glioma(12;0.0143)|Melanoma(17;0.122)					TAGGCGGGCCCGGAACACCCC	0.587		NA											4	28					0	0	0	0
CATSPERB	79820	broad.mit.edu	37	14	92136312	92136312	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr14:92136312C>T	uc001xzs.1	-	14	1273	c.1133G>A	c.(1132-1134)AGG>AAG	p.R378K	CATSPERB_uc010aub.1_5'UTR	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	378					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GGCAGTTTTCCTGACCTAGGT	0.358		NA											21	42					0	0	0	0
CYLD	1540	broad.mit.edu	37	16	50818266	50818266	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr16:50818266A>C	uc002egp.1	+	12	2268	c.1853A>C	c.(1852-1854)GAC>GCC	p.D618A	CYLD_uc002ego.2_Missense_Mutation_p.D615A|CYLD_uc010cbs.1_Missense_Mutation_p.D615A|CYLD_uc002egq.1_Missense_Mutation_p.D615A|CYLD_uc002egr.1_Missense_Mutation_p.D615A|CYLD_uc002egs.1_Missense_Mutation_p.D615A	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	618					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TCTGTTCTGGACACTGTGTTA	0.318		NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				18	56					0	0	0	0
CCDC113	29070	broad.mit.edu	37	16	58287951	58287951	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr16:58287951T>C	uc002ene.2	+	3	357	c.278T>C	c.(277-279)GTA>GCA	p.V93A	CCDC113_uc010vid.1_Intron	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	93						protein complex					0						GACCGTGGGGTAGGCCTGACT	0.507		NA											6	75					0	0	0	0
RASL10B	91608	broad.mit.edu	37	17	34067531	34067531	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr17:34067531G>A	uc002hju.2	+	3	686	c.320G>A	c.(319-321)CGC>CAC	p.R107H		NM_033315	NP_201572	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B precursor	107	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			lung(2)|breast(2)	4				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAGACCATCCGCCAGCAGATC	0.577		NA											21	43					0	0	0	0
ABCA8	10351	broad.mit.edu	37	17	66898960	66898960	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr17:66898960T>C	uc002jhp.2	-	19	2717	c.2538A>G	c.(2536-2538)ATA>ATG	p.I846M	ABCA8_uc002jhq.2_Missense_Mutation_p.I886M|ABCA8_uc010wqq.1_Missense_Mutation_p.I886M|ABCA8_uc010wqr.1_Missense_Mutation_p.I825M|ABCA8_uc002jhr.2_Missense_Mutation_p.I886M	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	846						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TGTTTTGATATATTTTCACCA	0.378		NA											15	62					0	0	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241452	60241452	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr18:60241452A>C	uc002lip.3	+	13	2138	c.2138A>C	c.(2137-2139)TAT>TCT	p.Y713S	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Missense_Mutation_p.Y183S	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	713					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TCACCCAAGTATCAGCATATT	0.443		NA											46	178					0	0	0	0
DAPK3	1613	broad.mit.edu	37	19	3964913	3964913	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr19:3964913G>A	uc002lzc.1	-	2	232	c.139C>T	c.(139-141)CGC>TGC	p.R47C	DAPK3_uc002lzd.1_Missense_Mutation_p.R47C	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	47	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GACAGGCGGCGCTTCTTGATG	0.572		NA											24	73					0	0	0	0
DNMT1	1786	broad.mit.edu	37	19	10249194	10249194	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr19:10249194G>A	uc002mng.2	-	34	4168	c.3988C>T	c.(3988-3990)CCA>TCA	p.P1330S	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Missense_Mutation_p.P254S|DNMT1_uc010xlc.1_Missense_Mutation_p.P1346S|DNMT1_uc002mnh.2_Missense_Mutation_p.P1225S|DNMT1_uc010xld.1_Missense_Mutation_p.P1330S	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1330	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	ACGTGCAGTGGCTCCGGGAAC	0.652		NA											12	57					0	0	0	0
NOTCH3	4854	broad.mit.edu	37	19	15298078	15298078	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr19:15298078C>T	uc002nan.2	-	11	1754	c.1678G>A	c.(1678-1680)GTG>ATG	p.V560M	NOTCH3_uc002nao.1_Missense_Mutation_p.V560M	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	560	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			ATGCCATCCACGCAGCGACCA	0.662		NA											10	36					0	0	0	0
NCAPH	23397	broad.mit.edu	37	2	97019076	97019076	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:97019076A>T	uc002svz.1	+	8	1027	c.943A>T	c.(943-945)ATC>TTC	p.I315F	NCAPH_uc010fhu.1_Missense_Mutation_p.I291F|NCAPH_uc010fhv.1_Missense_Mutation_p.I304F|NCAPH_uc010yum.1_Missense_Mutation_p.I291F|NCAPH_uc010fhw.1_Missense_Mutation_p.I304F|NCAPH_uc010yun.1_Missense_Mutation_p.I179F|NCAPH_uc002swa.1_5'UTR	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	315					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				AGATCGCCAGATCTGCCCTTC	0.502		NA											16	36					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165997340	165997340	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:165997340G>A	uc002ucx.2	-	13	2332	c.1840C>T	c.(1840-1842)CCG>TCG	p.P614S	SCN3A_uc002ucy.2_Missense_Mutation_p.P614S|SCN3A_uc002ucz.2_Missense_Mutation_p.P614S|SCN3A_uc002uda.1_Missense_Mutation_p.P483S|SCN3A_uc002udb.1_Missense_Mutation_p.P483S	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	614						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TGTCTGTGCGGCACAAACAGT	0.507		NA											4	59					0	0	0	0
SCN7A	6332	broad.mit.edu	37	2	167273486	167273486	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:167273486T>C	uc002udu.1	-	20	3272	c.3145A>G	c.(3145-3147)AGA>GGA	p.R1049G	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1049					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						ATCAAAGCTCTCACAACCACC	0.323		NA											4	15					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179598097	179598097	+	Missense_Mutation	SNP	C	C	T	rs146847928	by1000genomes	TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:179598097C>T	uc010zfg.1	-	51	12415	c.12191G>A	c.(12190-12192)CGA>CAA	p.R4064Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R725Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4991							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAACTTATTCGGTATTTTTT	0.473		NA											28	89					0	0	0	0
C20orf114	92747	broad.mit.edu	37	20	31890213	31890213	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr20:31890213G>A	uc002wyw.1	+	10	1137	c.976G>A	c.(976-978)GAA>AAA	p.E326K	C20orf114_uc002wyx.1_5'Flank	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	326						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						GCTGATCAATGAAAAGGTTGG	0.547		NA											12	58					0	0	0	0
APOL5	80831	broad.mit.edu	37	22	36122860	36122860	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr22:36122860G>A	uc003aof.2	+	3	745	c.745G>A	c.(745-747)GCC>ACC	p.A249T		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	249					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						CTACCAGATGGCCAAATCCAA	0.483		NA											4	207					0	0	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283603	40283603	+	Silent	SNP	G	G	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr22:40283603G>C	uc003ayg.2	-	2	401	c.150C>G	c.(148-150)CTC>CTG	p.L50L		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	50	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TAATCTCTGAGAGAGAAATTG	0.423		NA											28	92					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41565529	41565529	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr22:41565529G>A	uc003azl.3	+	26	4590	c.4195G>A	c.(4195-4197)GAT>AAT	p.D1399N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1399				D->Y: Does not interact with TFAP2A and inhibits transcriptional coactivation of TFAP2A by CITED2. Does not inhibit interaction with CITED2, DNA-binding of TFAP2A or nuclear localization of TFAP2A or CITED2.	apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399Y(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATCTTACCTCGATAGTGTTCA	0.338		NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				21	77					0	0	0	0
PFN2	5217	broad.mit.edu	37	3	149684321	149684321	+	Silent	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr3:149684321C>T	uc003ext.1	-	3	476	c.378G>A	c.(376-378)AAG>AAA	p.K126K	PFN2_uc003exs.1_Intron|PFN2_uc003exu.1_Intron|PFN2_uc011bnu.1_Intron	NM_053024	NP_444252	P35080	PROF2_HUMAN	profilin 2 isoform a	126					actin cytoskeleton organization|regulation of actin polymerization or depolymerization	actin cytoskeleton|cytoplasm	actin binding|phosphatidylinositol-4,5-bisphosphate binding				0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AGTATGCCTTCTTATTCAATC	0.393		NA											13	729					0	0	0	0
ECT2	1894	broad.mit.edu	37	3	172501696	172501696	+	Silent	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr3:172501696C>T	uc003fii.2	+	15	1770	c.1632C>T	c.(1630-1632)CTC>CTT	p.L544L	ECT2_uc010hwv.1_Silent_p.L575L|ECT2_uc003fih.2_Silent_p.L543L|ECT2_uc003fij.1_Silent_p.L544L|ECT2_uc003fik.1_Silent_p.L544L|ECT2_uc003fil.1_Silent_p.L575L	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	544	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			ATGCTTTTCTCAAGGTAATGT	0.269		NA											12	156					0	0	0	0
SULT1B1	27284	broad.mit.edu	37	4	70615521	70615521	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr4:70615521T>C	uc003hen.2	-	4	591	c.293A>G	c.(292-294)GAG>GGG	p.E98G		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	98					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						TGGATTCTTCTCCAATTGTTC	0.383		NA											17	72					0	0	0	0
HIST1H4D	8360	broad.mit.edu	37	6	26189157	26189157	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr6:26189157G>A	uc003ngu.2	-	1	148	c.148C>T	c.(148-150)CTC>TTC	p.L50F		NM_003539	NP_003530	P62805	H4_HUMAN	histone cluster 1, H4d	50					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				TCATAAATGAGGCCAGAAATA	0.542		NA											23	60					0	0	0	0
TRDN	10345	broad.mit.edu	37	6	123869615	123869615	+	Silent	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr6:123869615G>A	uc003pzj.1	-	3	397	c.375C>T	c.(373-375)GAC>GAT	p.D125D	TRDN_uc003pzk.1_Silent_p.D125D|TRDN_uc003pzl.1_Silent_p.D125D|TRDN_uc010ken.2_Silent_p.D125D|TRDN_uc010keo.1_Silent_p.D125D	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	125	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		CAGTATCTTCGTCACCATCAT	0.363		NA											4	13					0	0	0	0
LFNG	3955	broad.mit.edu	37	7	2565945	2565945	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:2565945G>A	uc003smf.2	+	6	906	c.889G>A	c.(889-891)GTG>ATG	p.V297M	LFNG_uc003smg.2_Missense_Mutation_p.V297M	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	297	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		CGGCTACATCGTGGAGGCCCT	0.657		NA											20	65					0	0	0	0
ADCY1	107	broad.mit.edu	37	7	45743232	45743232	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:45743232G>A	uc003tne.3	+	16	2623	c.2605G>A	c.(2605-2607)GTC>ATC	p.V869I		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	869	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCAGGTGGGCGTCATGTTTGC	0.572		NA											17	66					0	0	0	0
CYP51A1	1595	broad.mit.edu	37	7	91758200	91758200	+	Silent	SNP	A	A	G			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:91758200A>G	uc003ulm.3	-	3	624	c.462T>C	c.(460-462)CCT>CCC	p.P154P	CYP51A1_uc011khn.1_Silent_p.P49P|CYP51A1_uc003uln.3_Silent_p.P91P	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	148					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	CTACTGGATTAGGCACATCGT	0.363		NA											3	184					0	0	0	0
MLL5	55904	broad.mit.edu	37	7	104752281	104752281	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:104752281C>T	uc003vcm.2	+	27	4612	c.4078C>T	c.(4078-4080)CCT>TCT	p.P1360S	MLL5_uc010ljc.2_Missense_Mutation_p.P1360S|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.P94S	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1360					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCCTGGTTCACCTGGATCTGT	0.378		NA											13	40					0	0	0	0
EXOC4	60412	broad.mit.edu	37	7	133689777	133689777	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr7:133689777A>G	uc003vrk.2	+	16	2496	c.2461A>G	c.(2461-2463)ATC>GTC	p.I821V	EXOC4_uc011kpo.1_Missense_Mutation_p.I720V|EXOC4_uc003vrl.2_Missense_Mutation_p.I431V|EXOC4_uc011kpp.1_Missense_Mutation_p.I353V|EXOC4_uc011kpq.1_Missense_Mutation_p.I109V	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	821					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				CAACAAAGATATCAGCGCCAT	0.498		NA											3	133					0	0	0	0
BRWD3	254065	broad.mit.edu	37	X	79979296	79979296	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chrX:79979296T>C	uc004edt.2	-	16	1864	c.1601A>G	c.(1600-1602)CAT>CGT	p.H534R	BRWD3_uc004edo.2_Missense_Mutation_p.H130R|BRWD3_uc004edp.2_Missense_Mutation_p.H363R|BRWD3_uc004edq.2_Missense_Mutation_p.H130R|BRWD3_uc010nmj.1_Missense_Mutation_p.H130R|BRWD3_uc004edr.2_Missense_Mutation_p.H204R|BRWD3_uc004eds.2_Missense_Mutation_p.H130R|BRWD3_uc004edu.2_Missense_Mutation_p.H204R|BRWD3_uc004edv.2_Missense_Mutation_p.H130R|BRWD3_uc004edw.2_Missense_Mutation_p.H130R|BRWD3_uc004edx.2_Missense_Mutation_p.H130R|BRWD3_uc004edy.2_Missense_Mutation_p.H130R|BRWD3_uc004edz.2_Missense_Mutation_p.H204R|BRWD3_uc004eea.2_Missense_Mutation_p.H204R|BRWD3_uc004eeb.2_Missense_Mutation_p.H130R	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	534	WD 9.									ovary(4)	4						CAAATGTCCATGAGAATCTGT	0.303		NA											13	19					0	0	0	0
RAB40AL	282808	broad.mit.edu	37	X	102192947	102192947	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chrX:102192947G>A	uc004ejs.2	+	1	748	c.701G>A	c.(700-702)AGG>AAG	p.R234K		NM_001031834	NP_001027004	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	234					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			ovary(2)	2						CTGAATGCCAGGATGATGCGA	0.587		NA											48	49					0	0	0	0
IPO13	9670	broad.mit.edu	37	1	44433110	44433117	+	Frame_Shift_Del	DEL	TTCCCCTC	TTCCCCTC	-			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr1:44433110_44433117delTTCCCCTC	uc001ckx.2	+	19	3532_3539	c.2737_2744delTTCCCCTC	c.(2737-2745)TTCCCCTCTfs	p.F913fs	IPO13_uc001cky.2_Frame_Shift_Del_p.F131fs	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	913_915					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCCACCTGGTTTCCCCTCTGCCCGCCTC	0.615		NA											20	55	---	---	---	---	NA	NA	NA	NA
TTN	7273	broad.mit.edu	37	2	179597035	179597035	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr2:179597035delA	uc010zfg.1	-	54	13153	c.12929delT	c.(12928-12930)CTGfs	p.L4310fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.L971fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5237							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTTTAACAGCTGTGATGG	0.393		NA											38	155	---	---	---	---	NA	NA	NA	NA
ATR	545	broad.mit.edu	37	3	142274740	142274740	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-6470-01A-11D-1870-08	TCGA-CR-6470-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	30bc4d1e-f0cb-44c5-a32c-b4b690cd6cc5	59978c6f-681c-4364-af89-f56717688b71	g.chr3:142274740delT	uc003eux.3	-	10	2442	c.2320delA	c.(2320-2322)ATAfs	p.I774fs		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	774					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GGACTAGGTATTTTTTTTTTC	0.328		NA						Other_conserved_DNA_damage_response_genes					9	200	---	---	---	---	NA	NA	NA	NA