Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ATAD3C	219293	broad.mit.edu	37	1	1390860	1390860	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:1390860C>T	uc001aft.2	+	5	1394	c.399C>T	c.(397-399)CTC>CTT	p.L133L		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	133							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGCGGCTCCTCAGTCGACCCC	0.667		NA											8	21					0	0	0	0
SPSB1	80176	broad.mit.edu	37	1	9427562	9427562	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:9427562G>C	uc010oae.1	+	3	1089	c.750G>C	c.(748-750)GGG>GGC	p.G250G	SPSB1_uc001apv.2_Silent_p.G250G	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	250	SOCS box.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		TGGCCCTGGGGAGGGAGCGCC	0.672		NA											13	46					0	0	0	0
SPSB1	80176	broad.mit.edu	37	1	9427566	9427566	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:9427566G>A	uc010oae.1	+	3	1093	c.754G>A	c.(754-756)GAG>AAG	p.E252K	SPSB1_uc001apv.2_Missense_Mutation_p.E252K	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	252	SOCS box.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGGGGAGGGAGCGCCTGGG	0.672		NA											13	43					0	0	0	0
CASZ1	54897	broad.mit.edu	37	1	10702951	10702951	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:10702951G>A	uc001aro.2	-	20	4447	c.4127C>T	c.(4126-4128)TCC>TTC	p.S1376F		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGGGGTGCTGGAGCAGCTCCG	0.667		NA											3	22					0	0	0	0
CASZ1	54897	broad.mit.edu	37	1	10703259	10703259	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:10703259C>T	uc001aro.2	-	19	4298	c.3978G>A	c.(3976-3978)CGG>CGA	p.R1326R		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CCAGCATCCTCCGCATGTGCT	0.652		NA											7	49					0	0	0	0
LOC649330	649330	broad.mit.edu	37	1	12907868	12907868	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:12907868C>T	uc009vno.2	-	1	370	c.275G>A	c.(274-276)CGA>CAA	p.R92Q	HNRNPCL1_uc010obf.1_Missense_Mutation_p.R92Q	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	92							nucleic acid binding|nucleotide binding				0						TGCGTTTCCTCGGTTCACTTT	0.483		NA											9	150					0	0	0	0
KAZ	23254	broad.mit.edu	37	1	15392164	15392164	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:15392164G>A	uc001avm.3	+	8	1418	c.1137G>A	c.(1135-1137)AAG>AAA	p.K379K	KAZ_uc009vog.1_Silent_p.K379K|KAZ_uc010obj.1_Silent_p.K379K|KAZ_uc001avo.2_Silent_p.K373K|KAZ_uc001avp.2_Silent_p.K285K|KAZ_uc001avq.2_Silent_p.K285K|KAZ_uc001avr.2_3'UTR	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	379	Poly-Lys.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						GGAAAAAGAAGAAAGAGAAGA	0.552		NA											7	76					0	0	0	0
CROCC	9696	broad.mit.edu	37	1	17292539	17292539	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:17292539G>A	uc001azt.2	+	29	4690	c.4621G>A	c.(4621-4623)GAG>AAG	p.E1541K	CROCC_uc001azu.2_Missense_Mutation_p.E844K|CROCC_uc001azv.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1541	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCAGCTGGCCGAGATGGAGGC	0.632		NA											6	34					0	0	0	0
RUNX3	864	broad.mit.edu	37	1	25254140	25254140	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:25254140G>A	uc001bjq.2	-	2	775	c.364C>T	c.(364-366)CGC>TGC	p.R122C	RUNX3_uc010oen.1_Missense_Mutation_p.R122C|RUNX3_uc009vrj.2_Missense_Mutation_p.R136C|RUNX3_uc001bjr.2_Missense_Mutation_p.R136C	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	122	Runt.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GAGGCATTGCGCAGCTCAGCG	0.632		NA											14	104					0	0	0	0
BAI2	576	broad.mit.edu	37	1	32210323	32210323	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:32210323G>A	uc001btn.2	-	5	1202	c.848C>T	c.(847-849)CCG>CTG	p.P283L	BAI2_uc010ogo.1_5'UTR|BAI2_uc010ogp.1_Missense_Mutation_p.P271L|BAI2_uc010ogq.1_Missense_Mutation_p.P283L|BAI2_uc001bto.2_Missense_Mutation_p.P283L|BAI2_uc001btq.1_Missense_Mutation_p.P271L|BAI2_uc010ogr.1_Missense_Mutation_p.P271L	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	283	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TTCCTCTTCCGGCTCCTCACC	0.612		NA											6	39					0	0	0	0
ZMYM1	79830	broad.mit.edu	37	1	35578687	35578687	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:35578687C>T	uc001bym.2	+	11	1404	c.1256C>T	c.(1255-1257)TCC>TTC	p.S419F	ZMYM1_uc001byn.2_Missense_Mutation_p.S419F|ZMYM1_uc010ohu.1_Missense_Mutation_p.S400F|ZMYM1_uc001byo.2_Missense_Mutation_p.S59F|ZMYM1_uc009vut.2_Missense_Mutation_p.S344F	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	419	Ser-rich.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCAATTGGTTCCAGTACAGAA	0.368		NA											6	27					0	0	0	0
MACF1	23499	broad.mit.edu	37	1	39750825	39750825	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:39750825G>A	uc010ois.1	+	13	1422	c.1217G>A	c.(1216-1218)GGA>GAA	p.G406E	MACF1_uc001cda.1_Missense_Mutation_p.G314E	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	406					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGAGTGGGGAAAGCTCATC	0.458		NA											14	68					0	0	0	0
KIAA0754	643314	broad.mit.edu	37	1	39876389	39876389	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:39876389C>T	uc009vvt.1	+	1	1214	c.452C>T	c.(451-453)TCT>TTT	p.S151F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	15											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATAGAAGCTTCTCTCAGTGAG	0.468		NA											6	115					0	0	0	0
SLFNL1	200172	broad.mit.edu	37	1	41481844	41481844	+	Silent	SNP	C	C	T	rs142166637		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:41481844C>T	uc001cgm.1	-	5	1378	c.1158G>A	c.(1156-1158)GAG>GAA	p.E386E	SLFNL1_uc009vwf.1_Silent_p.E338E|SLFNL1_uc001cgn.1_Silent_p.E327E|SLFNL1_uc009vwg.1_Silent_p.E386E	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	386	Potential.						ATP binding	p.E386E(1)		skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				GCTGCTCCTTCTCCATCATCA	0.637		NA											14	94					0	0	0	0
SLFNL1	200172	broad.mit.edu	37	1	41481853	41481853	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:41481853C>T	uc001cgm.1	-	5	1369	c.1149G>A	c.(1147-1149)CTG>CTA	p.L383L	SLFNL1_uc009vwf.1_Silent_p.L335L|SLFNL1_uc001cgn.1_Silent_p.L324L|SLFNL1_uc009vwg.1_Silent_p.L383L	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	383	Potential.						ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				TCTCCATCATCAGCGCCTTCA	0.642		NA											15	90					0	0	0	0
KIF2C	11004	broad.mit.edu	37	1	45221866	45221866	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:45221866G>C	uc001cmg.3	+	10	1049	c.934G>C	c.(934-936)GAC>CAC	p.D312H	KIF2C_uc010olb.1_Missense_Mutation_p.D271H|KIF2C_uc010olc.1_Missense_Mutation_p.D199H|KIF2C_uc001cmh.3_Missense_Mutation_p.D258H	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	312	Kinesin-motor.				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ATTCTGCTTTGACTTTGCATT	0.423		NA											28	143					0	0	0	0
CYP4A11	1579	broad.mit.edu	37	1	47398445	47398445	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:47398445G>C	uc001cqp.3	-	11	1403	c.1352C>G	c.(1351-1353)TCA>TGA	p.S451*	CYP4A11_uc001cqq.2_Nonsense_Mutation_p.S451*	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	451					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	TGATCCTCCTGAGAAGGGCAG	0.507		NA											61	311					0	0	0	0
CMPK1	51727	broad.mit.edu	37	1	47840885	47840885	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:47840885C>T	uc001cri.2	+	5	714	c.565C>T	c.(565-567)CAG>TAG	p.Q189*	CMPK1_uc010omp.1_Nonsense_Mutation_p.Q140*|CMPK1_uc010omq.1_RNA	NM_016308	NP_057392	P30085	KCY_HUMAN	UMP-CMP kinase 1 isoform a	157					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			ovary(1)	1					Gemcitabine(DB00441)	GACCTACCTTCAGTCAACAAA	0.368		NA											24	140					0	0	0	0
FAM159A	348378	broad.mit.edu	37	1	53108622	53108622	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:53108622C>T	uc001cuf.2	+	2	370	c.270C>T	c.(268-270)ATC>ATT	p.I90I	FAM159A_uc001cug.1_RNA|FAM159A_uc001cuh.2_RNA	NM_001042693	NP_001036158	Q6UWV7	F159A_HUMAN	hypothetical protein LOC348378	90	Helical; (Potential).					integral to membrane					0						ACCTGTTCATCAGCTCTAAGC	0.527		NA											20	125					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75038328	75038328	+	Silent	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:75038328G>T	uc001dgg.2	-	14	3285	c.3066C>A	c.(3064-3066)GCC>GCA	p.A1022A		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1022	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TGCAAAGGAAGGCTTCCTTTG	0.502		NA											17	95					0.000175454	0.000181819	1	0
ASB17	127247	broad.mit.edu	37	1	76397847	76397847	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:76397847C>A	uc001dhe.1	-	1	270	c.130G>T	c.(130-132)GAA>TAA	p.E44*	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	44					intracellular signal transduction					ovary(1)	1						ATCCTTGGTTCGTAACAGTGA	0.398		NA											34	132					1.41e-09	1.5e-09	1	0
PRKACB	5567	broad.mit.edu	37	1	84650847	84650847	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:84650847G>A	uc001djj.2	+	5	665	c.401G>A	c.(400-402)AGA>AAA	p.R134K	PRKACB_uc001djl.2_Missense_Mutation_p.R181K|PRKACB_uc010ort.1_Missense_Mutation_p.R141K|PRKACB_uc001djn.2_Missense_Mutation_p.R138K|PRKACB_uc010oru.1_Missense_Mutation_p.R122K|PRKACB_uc001djp.2_Missense_Mutation_p.R140K|PRKACB_uc001djq.2_Missense_Mutation_p.R104K|PRKACB_uc010orv.1_Missense_Mutation_p.R121K|PRKACB_uc001dji.2_Missense_Mutation_p.R134K|PRKACB_uc001djk.2_Missense_Mutation_p.R181K|PRKACB_uc009wcf.1_Missense_Mutation_p.R140K	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	134	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TCACATCTAAGAAGAATTGGA	0.308		NA											23	152					0	0	0	0
RPF1	80135	broad.mit.edu	37	1	84948646	84948646	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:84948646G>A	uc001djv.3	+	3	379	c.334G>A	c.(334-336)GAT>AAT	p.D112N		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	112					rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						GCGAGTGTATGATGAAACCAC	0.318		NA											6	32					0	0	0	0
COL24A1	255631	broad.mit.edu	37	1	86313410	86313410	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:86313410C>G	uc001dlj.2	-	39	3442	c.3400G>C	c.(3400-3402)GGT>CGT	p.G1134R	COL24A1_uc001dli.2_Missense_Mutation_p.G270R|COL24A1_uc010osd.1_Missense_Mutation_p.G434R|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1134	Collagen-like 11.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CCAGGAGGACCTCTGCTTCCA	0.418		NA											15	121					0	0	0	0
CLCA1	1179	broad.mit.edu	37	1	86964330	86964330	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:86964330G>C	uc001dlt.2	+	13	2318	c.2189G>C	c.(2188-2190)AGA>ACA	p.R730T		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	730					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TGTTTCAGCAGAACATCCTCG	0.423		NA											13	94					0	0	0	0
ABCA4	24	broad.mit.edu	37	1	94502326	94502326	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:94502326C>T	uc001dqh.2	-	26	3936	c.3832G>A	c.(3832-3834)GAG>AAG	p.E1278K		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1278	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCAGAATCCTCCGTGACCTTC	0.438		NA											31	125					0	0	0	0
ABCA4	24	broad.mit.edu	37	1	94577116	94577116	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:94577116C>G	uc001dqh.2	-	3	284	c.180G>C	c.(178-180)GCG>GCC	p.A60A	ABCA4_uc010otn.1_Silent_p.A60A	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	60	Extracellular.		A -> T (in STGD1).|A -> E (in STGD1).|A -> V (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTGAGGGCATCGCCTTGTTGG	0.512		NA											10	52					0	0	0	0
FAM102B	284611	broad.mit.edu	37	1	109154857	109154857	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:109154857C>T	uc010ouy.1	+	4	426	c.346C>T	c.(346-348)CGC>TGC	p.R116C		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	116										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		TACCACTCGCCGCTGTTTACT	0.363		NA											24	72					0	0	0	0
CSF1	1435	broad.mit.edu	37	1	110466425	110466425	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:110466425C>G	uc001dyu.2	+	6	1595	c.1182C>G	c.(1180-1182)CTC>CTG	p.L394L	CSF1_uc001dyt.2_Intron|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Silent_p.L394L	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	394	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGCCCTGCTCAGAGACCCCC	0.642		NA											9	39					0	0	0	0
GOLPH3L	55204	broad.mit.edu	37	1	150634351	150634351	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:150634351C>T	uc001evj.2	-	4	586	c.369G>A	c.(367-369)CTG>CTA	p.L123L	GOLPH3L_uc010pci.1_Silent_p.L79L	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	123						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGATGTGTTTCAGAGTTTCAT	0.388		NA											17	95					0	0	0	0
DCST1	149095	broad.mit.edu	37	1	155011959	155011959	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:155011959G>A	uc001fgn.1	+	5	439	c.343G>A	c.(343-345)GAA>AAA	p.E115K	DCST1_uc010per.1_Missense_Mutation_p.E140K|DCST1_uc010pes.1_Missense_Mutation_p.E90K	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	115	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GCTGGGCAAGGAAGGCAGGCT	0.612		NA											5	97					0	0	0	0
FCRL3	115352	broad.mit.edu	37	1	157648586	157648586	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:157648586C>T	uc001frb.2	-	15	2411	c.2119G>A	c.(2119-2121)GCT>ACT	p.A707T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.A707T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.A433T|FCRL3_uc001frc.1_Missense_Mutation_p.A707T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	707	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTGCTGCTAGCCTCCCCTGCA	0.468		NA											12	56					0	0	0	0
FCRL3	115352	broad.mit.edu	37	1	157665912	157665912	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:157665912C>G	uc001frb.2	-	7	1342	c.1050G>C	c.(1048-1050)GAG>GAC	p.E350D	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.E350D|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.E76D|FCRL3_uc001frc.1_Missense_Mutation_p.E350D	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	350	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTGCATCACTCTCCTTCACGG	0.512		NA											9	64					0	0	0	0
SDHC	6391	broad.mit.edu	37	1	161326611	161326611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:161326611G>A	uc001gag.2	+	5	416	c.386G>A	c.(385-387)TGG>TAG	p.W129*	SDHC_uc001gai.2_Intron|SDHC_uc001gaj.2_Nonsense_Mutation_p.W76*|SDHC_uc001gak.2_Intron|SDHC_uc001gah.2_Nonsense_Mutation_p.W95*	NM_003001	NP_002992	Q99643	C560_HUMAN	succinate dehydrogenase complex, subunit C	129	Helical; (By similarity).				respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II|plasma membrane succinate dehydrogenase complex	electron carrier activity|heme binding|succinate dehydrogenase activity				0	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Succinic acid(DB00139)	TATCATACCTGGAATGGGATC	0.463		NA	Mis|N|F			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome				24	143					0	0	0	0
RGS4	5999	broad.mit.edu	37	1	163039306	163039306	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:163039306C>G	uc009wuy.2	+	1	543	c.32C>G	c.(31-33)TCT>TGT	p.S11C	RGS4_uc001gcl.3_Missense_Mutation_p.S108C|RGS4_uc009wuz.2_Missense_Mutation_p.S11C|RGS4_uc009wva.2_5'Flank	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	11					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						CTGCCGGCTTCTTGCTTGAGG	0.438		NA									OREG0013952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	42					0	0	0	0
DUSP27	92235	broad.mit.edu	37	1	167095830	167095830	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:167095830G>C	uc001geb.1	+	5	1462	c.1462G>C	c.(1462-1464)GAG>CAG	p.E488Q		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	488					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GCTGGAGATTGAGAAGGAGGC	0.647		NA											7	27					0	0	0	0
DUSP27	92235	broad.mit.edu	37	1	167097324	167097324	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:167097324G>A	uc001geb.1	+	5	2956	c.2956G>A	c.(2956-2958)GAG>AAG	p.E986K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	986	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						ATCCCAGTCAGAGGAACAGGA	0.517		NA											12	59					0	0	0	0
C1orf114	57821	broad.mit.edu	37	1	169390719	169390719	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:169390719G>C	uc001gga.1	-	3	1118	c.950C>G	c.(949-951)TCT>TGT	p.S317C	C1orf114_uc001gfz.1_Missense_Mutation_p.S317C|C1orf114_uc009wvq.1_Missense_Mutation_p.S317C|C1orf114_uc001ggb.2_Missense_Mutation_p.S317C|C1orf114_uc001ggc.1_Missense_Mutation_p.S317C	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	317											0	all_hematologic(923;0.208)					CCTGTGATTAGATTTCCCATT	0.458		NA											21	97					0	0	0	0
SOAT1	6646	broad.mit.edu	37	1	179311274	179311274	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:179311274C>T	uc001gml.2	+	8	869	c.806C>T	c.(805-807)TCA>TTA	p.S269L	SOAT1_uc010pni.1_Missense_Mutation_p.S204L|SOAT1_uc001gmm.2_Missense_Mutation_p.S211L|SOAT1_uc010pnj.1_Missense_Mutation_p.S5L|SOAT1_uc010pnk.1_Missense_Mutation_p.S204L	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	269					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	AAGGCCCACTCATTTGTCAGA	0.343		NA											14	52					0	0	0	0
QSOX1	5768	broad.mit.edu	37	1	180163447	180163447	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:180163447C>G	uc001gnz.2	+	11	1463	c.1388C>G	c.(1387-1389)TCC>TGC	p.S463C	QSOX1_uc001gny.2_Missense_Mutation_p.S463C|QSOX1_uc001goa.2_Missense_Mutation_p.S463C|QSOX1_uc001goc.2_Missense_Mutation_p.S5C	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	463	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						GCTGCTGCCTCCATGCACCGG	0.627		NA											12	48					0	0	0	0
RGS16	6004	broad.mit.edu	37	1	182569610	182569610	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:182569610C>T	uc001gpl.3	-	5	580	c.426G>A	c.(424-426)ATG>ATA	p.M142I		NM_002928	NP_002919	O15492	RGS16_HUMAN	regulator of G-protein signalling 16	142	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(1)	1						TCTGCAGGTTCATCCTCGTCA	0.592		NA											10	64					0	0	0	0
LAMC2	3918	broad.mit.edu	37	1	183209330	183209330	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:183209330G>C	uc001gqa.2	+	21	3539	c.3225G>C	c.(3223-3225)CAG>CAC	p.Q1075H	LAMC2_uc001gpz.3_Missense_Mutation_p.Q1075H|LAMC2_uc010poa.1_Missense_Mutation_p.Q775H	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1075	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						ATGCAGTACAGATGGTGAGTT	0.473		NA											22	81					0	0	0	0
RGL1	23179	broad.mit.edu	37	1	183775568	183775568	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:183775568C>T	uc001gqo.2	+	2	244	c.87C>T	c.(85-87)CTC>CTT	p.L29L	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Silent_p.L64L|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron|RGL1_uc010poi.1_Silent_p.L29L	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	29					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						ATGTCACCCTCAAAAGAGTCC	0.473		NA											19	80					0	0	0	0
RGL1	23179	broad.mit.edu	37	1	183853004	183853004	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:183853004C>T	uc001gqo.2	+	6	852	c.695C>T	c.(694-696)TCA>TTA	p.S232L	RGL1_uc010pof.1_Missense_Mutation_p.S37L|RGL1_uc001gqm.2_Missense_Mutation_p.S267L|RGL1_uc010pog.1_Missense_Mutation_p.S230L|RGL1_uc010poh.1_Missense_Mutation_p.S230L|RGL1_uc010poi.1_Missense_Mutation_p.S232L	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	232	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						ACGTGCTTCTCAGAAGATCTC	0.483		NA											25	111					0	0	0	0
RNF2	6045	broad.mit.edu	37	1	185062311	185062311	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:185062311C>T	uc001grc.1	+	4	600	c.367C>T	c.(367-369)CAT>TAT	p.H123Y	RNF2_uc001grd.1_Intron|RNF2_uc001gre.1_RNA	NM_007212	NP_009143	Q99496	RING2_HUMAN	ring finger protein 2	123	Interaction with HIP2.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(1)	1		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		GTATGAAGCTCATCAAGAGAG	0.423		NA											6	44					0	0	0	0
PRG4	10216	broad.mit.edu	37	1	186275736	186275736	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:186275736G>A	uc001gru.3	+	7	936	c.885G>A	c.(883-885)CAG>CAA	p.Q295Q	PRG4_uc001grt.3_Silent_p.Q254Q|PRG4_uc009wyl.2_Silent_p.Q202Q|PRG4_uc009wym.2_Silent_p.Q161Q|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	295					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAAATAAACAGACTTCAACTG	0.368		NA											32	174					0	0	0	0
TPR	7175	broad.mit.edu	37	1	186315362	186315362	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:186315362G>A	uc001grv.2	-	23	3298	c.3001C>T	c.(3001-3003)CAG>TAG	p.Q1001*		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1001	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AACTGTGTCTGAAATTCAGCT	0.348		NA	T	NTRK1	papillary thyroid								10	78					0	0	0	0
F13B	2165	broad.mit.edu	37	1	197031034	197031034	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:197031034G>C	uc001gtt.1	-	3	375	c.331C>G	c.(331-333)CAA>GAA	p.Q111E		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	111	Sushi 2.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATGTTCTCTTGAATTTTATAC	0.373		NA											6	35					0	0	0	0
KIF14	9928	broad.mit.edu	37	1	200524573	200524573	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:200524573C>G	uc010ppk.1	-	28	4802	c.4363G>C	c.(4363-4365)GAA>CAA	p.E1455Q	KIF14_uc010ppj.1_Missense_Mutation_p.E964Q	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1455	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding	p.E1455Q(1)		breast(3)|ovary(2)|skin(2)	7						GTTTTCATTTCTTTGGTAACC	0.259		NA											8	34					0	0	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204197211	204197211	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:204197211C>T	uc001hau.2	-	21	3348	c.3031G>A	c.(3031-3033)GTG>ATG	p.V1011M		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	1011										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			CCCCTCTCACCAGACAGCATG	0.647		NA											7	28					0	0	0	0
PIGR	5284	broad.mit.edu	37	1	207112542	207112542	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:207112542C>T	uc001hez.2	-	3	494	c.310G>A	c.(310-312)GAC>AAC	p.D104N	PIGR_uc009xbz.2_Missense_Mutation_p.D104N	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	104	Ig-like V-type 1.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGCCCGGAGTCATCCTGGCTC	0.582		NA											9	27					0	0	0	0
KCNH1	3756	broad.mit.edu	37	1	210856787	210856787	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:210856787C>T	uc001hib.2	-	11	2976	c.2806G>A	c.(2806-2808)GAC>AAC	p.D936N	KCNH1_uc001hic.2_Missense_Mutation_p.D909N	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	936	Cytoplasmic (Potential).|CAD (involved in subunit assembly) (By similarity).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GCCTTGATGTCCTCCTTCAGC	0.517		NA											12	50					0	0	0	0
TP53BP2	7159	broad.mit.edu	37	1	223990037	223990037	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:223990037C>T	uc010pvb.1	-	9	1298	c.1006G>A	c.(1006-1008)GAT>AAT	p.D336N	TP53BP2_uc001hod.2_Missense_Mutation_p.D207N|TP53BP2_uc010puz.1_5'Flank|TP53BP2_uc010pva.1_5'UTR	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	330					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		AGATTTCCATCAGATGAAACC	0.458		NA											7	49					0	0	0	0
TP53BP2	7159	broad.mit.edu	37	1	223990487	223990487	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:223990487C>G	uc010pvb.1	-	8	1234	c.942G>C	c.(940-942)CTG>CTC	p.L314L	TP53BP2_uc001hod.2_Silent_p.L185L|TP53BP2_uc010puz.1_5'Flank|TP53BP2_uc010pva.1_5'Flank	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	308					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCCGGTCCCTCAGCTCATTAA	0.443		NA											32	131					0	0	0	0
CAPN9	10753	broad.mit.edu	37	1	230907820	230907820	+	Missense_Mutation	SNP	G	G	C	rs145028426		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:230907820G>C	uc001htz.1	+	7	963	c.850G>C	c.(850-852)GAG>CAG	p.E284Q	CAPN9_uc009xfg.1_Missense_Mutation_p.E221Q|CAPN9_uc001hua.1_Missense_Mutation_p.E284Q	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	284	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GGGCCAGGTTGAGTGGAACGG	0.572		NA											9	58					0	0	0	0
KIAA1383	54627	broad.mit.edu	37	1	232942141	232942141	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:232942141C>T	uc001hvh.2	+	1	1504	c.1372C>T	c.(1372-1374)CCT>TCT	p.P458S		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	316										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				AAAACCGCCCCCTGCACAGGC	0.448		NA											27	167					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235915332	235915332	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:235915332G>A	uc001hxj.2	-	27	7775	c.7600C>T	c.(7600-7602)CAA>TAA	p.Q2534*	LYST_uc009xga.1_Nonsense_Mutation_p.Q116*	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2534					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGCTATTTTGAAGATATCCA	0.343		NA							Chediak-Higashi_syndrome				8	26					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235922480	235922480	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:235922480G>A	uc001hxj.2	-	23	6848	c.6673C>T	c.(6673-6675)CGC>TGC	p.R2225C	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2225					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCAGGTCGGCGTGGGCAGGAC	0.532		NA							Chediak-Higashi_syndrome				12	55					0	0	0	0
ZNF124	7678	broad.mit.edu	37	1	247322349	247322349	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:247322349C>G	uc001ick.2	-	3	316	c.177G>C	c.(175-177)CAG>CAC	p.Q59H	ZNF124_uc001ici.2_RNA|ZNF124_uc001icj.1_Missense_Mutation_p.Q59H	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			CTTCAATGCTCTGGTCTTCCC	0.318		NA											7	28					0	0	0	0
OR2M4	26245	broad.mit.edu	37	1	248402793	248402793	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr1:248402793C>G	uc010pzh.1	+	1	563	c.563C>G	c.(562-564)TCC>TGC	p.S188C		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTACCTCTATCCTGCACAGAA	0.403		NA											6	141					0	0	0	0
ITIH2	3698	broad.mit.edu	37	10	7759731	7759731	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:7759731C>T	uc001ijs.2	+	6	772	c.610C>T	c.(610-612)CGG>TGG	p.R204W		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	204					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						GCAACCTGGACGGCTGGCCAA	0.512		NA											24	135					0	0	0	0
C10orf111	221060	broad.mit.edu	37	10	15138708	15138708	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:15138708C>T	uc001inw.2	-	2	390	c.116G>A	c.(115-117)AGA>AAA	p.R39K	RPP38_uc001iny.3_5'Flank|RPP38_uc009xjm.2_5'Flank|RPP38_uc001inx.3_5'Flank	NM_153244	NP_694976	Q8N326	CJ111_HUMAN	hypothetical protein LOC221060	39						integral to membrane					0						TACTGCCTTTCTCTTTTCGGG	0.498		NA											33	112					0	0	0	0
VIM	7431	broad.mit.edu	37	10	17275592	17275592	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:17275592G>C	uc001iou.2	+	4	1044	c.631G>C	c.(631-633)GAC>CAC	p.D211H	VIM_uc001iov.1_Missense_Mutation_p.D211H|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.D211H|VIM_uc001ioy.1_Missense_Mutation_p.D211H|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.D211H|VIM_uc001ipc.1_Missense_Mutation_p.D211H	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	211	Rod.|Coil 1B.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						ATAGGATGTTGACAATGCGTC	0.403		NA											7	37					0	0	0	0
SLC39A12	221074	broad.mit.edu	37	10	18250518	18250518	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:18250518A>T	uc001ipo.2	+	3	543	c.270A>T	c.(268-270)GAA>GAT	p.E90D	SLC39A12_uc001ipn.2_Missense_Mutation_p.E90D|SLC39A12_uc001ipp.2_Missense_Mutation_p.E90D|SLC39A12_uc010qck.1_5'UTR	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	90	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AGTGCTTTGAACCAGATGCAC	0.368		NA											11	65					0	0	0	0
DNAJC1	64215	broad.mit.edu	37	10	22209807	22209807	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:22209807C>A	uc001irc.2	-	4	744	c.457G>T	c.(457-459)GAG>TAG	p.E153*	DNAJC1_uc001ird.2_Nonsense_Mutation_p.E39*	NM_022365	NP_071760	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	153	Lumenal (By similarity).				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				AATGCCAGCTCAGCATTGCTC	0.398		NA											12	63					0.000978159	0.00100257	1	0
ANKRD26	22852	broad.mit.edu	37	10	27306526	27306526	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:27306526C>G	uc001ith.2	-	30	4580	c.4408G>C	c.(4408-4410)GAA>CAA	p.E1470Q	ANKRD26_uc001itg.2_Missense_Mutation_p.E1157Q|ANKRD26_uc009xku.1_Missense_Mutation_p.E1471Q	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1470	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TGACCAAGTTCTACCATATTC	0.318		NA											19	85					0	0	0	0
FZD8	8325	broad.mit.edu	37	10	35929113	35929113	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:35929113C>T	uc001iyz.1	-	1	1250	c.1245G>A	c.(1243-1245)GTG>GTA	p.V415V		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	415	Helical; Name=3; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						GCGACAAGATCACCCACCAGA	0.632		NA											10	38					0	0	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344019	38344019	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:38344019G>A	uc001izh.2	+	5	1142	c.964G>A	c.(964-966)GAT>AAT	p.D322N	ZNF33A_uc001izg.2_Missense_Mutation_p.D323N|ZNF33A_uc010qev.1_Missense_Mutation_p.D329N|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	322						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						TCAGAAAGGTGATAAAGGAGA	0.423		NA											14	85					0	0	0	0
ANK3	288	broad.mit.edu	37	10	61840377	61840377	+	Splice_Site	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:61840377C>T	uc001jky.2	-	36	4543	c.4351_splice	c.e36-1	p.I1451_splice	ANK3_uc001jkw.2_Splice_Site_p.I576_splice|ANK3_uc009xpa.2_Splice_Site_p.I576_splice|ANK3_uc001jkx.2_Splice_Site_p.I620_splice|ANK3_uc010qih.1_Splice_Site_p.I1443_splice|ANK3_uc001jkz.3_Splice_Site_p.I1436_splice|ANK3_uc001jla.1_Intron|ANK3_uc001jkv.2_Splice_Site|ANK3_uc009xpb.1_5'Flank|ANK3_uc009xpc.1_5'Flank	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTTTCTCAATCTGAAAAGGAA	0.378		NA											6	37					0	0	0	0
PRF1	5551	broad.mit.edu	37	10	72358020	72358020	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:72358020T>A	uc009xqg.2	-	3	1618	c.1457A>T	c.(1456-1458)GAC>GTC	p.D486V	PRF1_uc001jrf.3_Missense_Mutation_p.D486V	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	486	C2.	Calcium 2; via carbonyl oxygen (By similarity).			apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CCTGCCAGAGTCCTGATCCCA	0.572		NA	M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				21	72					0	0	0	0
POLR3A	11128	broad.mit.edu	37	10	79784393	79784393	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:79784393C>T	uc001jzn.2	-	5	653	c.559G>A	c.(559-561)GAT>AAT	p.D187N		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	187					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			ACAATGGGATCCACCACTTTT	0.383		NA											13	66					0	0	0	0
LRIT1	26103	broad.mit.edu	37	10	85994045	85994045	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:85994045C>T	uc001kcz.1	-	3	701	c.679G>A	c.(679-681)GAG>AAG	p.E227K		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	227	LRRCT.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						AGTTCAGTCTCAATGAAGGCC	0.582		NA											13	66					0	0	0	0
TMEM20	159371	broad.mit.edu	37	10	95660597	95660597	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:95660597G>A	uc001kjg.1	+	3	509	c.448G>A	c.(448-450)GCT>ACT	p.A150T	TMEM20_uc001kji.2_Intron|TMEM20_uc001kjf.1_Missense_Mutation_p.A149T|TMEM20_uc001kjh.2_Intron|TMEM20_uc010qnw.1_Missense_Mutation_p.A133T|TMEM20_uc001kjj.2_Intron	NM_001134658	NP_001128130	Q2M3R5	TMM20_HUMAN	transmembrane protein 20 isoform 1	150	DUF6 1.|Helical; (Potential).					integral to membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;3.46e-05)|Renal(717;0.018)|Ovarian(717;0.0228)|all_hematologic(284;0.189)		STAD - Stomach adenocarcinoma(243;0.00345)		TATATACTATGCTTACCAGAC	0.413		NA											15	69					0	0	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97373783	97373783	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:97373783C>T	uc001kkz.2	-	14	1983	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	ALDH18A1_uc001kky.2_Missense_Mutation_p.E579K|ALDH18A1_uc010qog.1_Missense_Mutation_p.E470K|ALDH18A1_uc010qoh.1_Missense_Mutation_p.E369K	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	581	Gamma-glutamyl phosphate reductase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	CAGATCCCTTCGCTGTGCCCC	0.502		NA											7	179					0	0	0	0
TLL2	7093	broad.mit.edu	37	10	98133495	98133495	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:98133495C>T	uc001kml.1	-	19	2746	c.2520G>A	c.(2518-2520)CCG>CCA	p.P840P		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	840	CUB 4.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CCAGGCTGTCCGGCCCGTCAT	0.542		NA											11	61					0	0	0	0
TLX1	3195	broad.mit.edu	37	10	102891411	102891411	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:102891411C>T	uc001ksw.2	+	1	351	c.113C>T	c.(112-114)TCG>TTG	p.S38L	TLX1NB_uc001ksv.2_5'Flank	NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GGACCCGCCTCGCGCCTCCAG	0.706		NA	T	TRB@|TRD@	T-ALL								4	16					0	0	0	0
PDCD11	22984	broad.mit.edu	37	10	105194617	105194617	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:105194617G>A	uc001kwy.1	+	25	3817	c.3730G>A	c.(3730-3732)GAG>AAG	p.E1244K		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1244	S1 motif 11.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GACTCCCAACGAGGGGCTGAC	0.547		NA											10	39					0	0	0	0
COL17A1	1308	broad.mit.edu	37	10	105819884	105819884	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:105819884G>A	uc001kxr.2	-	14	1303	c.1134C>T	c.(1132-1134)ATC>ATT	p.I378I	COL17A1_uc010qqv.1_Silent_p.I362I	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	378	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CACTTGCAGCGATGCTGGCAG	0.517		NA											9	67					0	0	0	0
ABLIM1	3983	broad.mit.edu	37	10	116213165	116213165	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:116213165G>A	uc010qsg.1	-	13	1618	c.1519C>T	c.(1519-1521)CAG>TAG	p.Q507*	ABLIM1_uc010qsh.1_Nonsense_Mutation_p.Q475*|ABLIM1_uc010qsi.1_Nonsense_Mutation_p.Q447*|ABLIM1_uc010qsk.1_Nonsense_Mutation_p.Q431*|ABLIM1_uc009xyp.2_Nonsense_Mutation_p.Q469*|ABLIM1_uc010qsf.1_Intron|ABLIM1_uc009xyn.2_Intron|ABLIM1_uc010qsj.1_Intron|ABLIM1_uc009xyo.2_Intron	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	507					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TTAGGGGCCTGAGCGTAAGTT	0.532		NA											6	54					0	0	0	0
ATRNL1	26033	broad.mit.edu	37	10	117059722	117059722	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:117059722C>T	uc001lcg.2	+	16	2980	c.2594C>T	c.(2593-2595)TCT>TTT	p.S865F	ATRNL1_uc010qsm.1_Missense_Mutation_p.S40F|ATRNL1_uc010qsn.1_5'Flank	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	865	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CCTTGTACATCTATGGCAAAT	0.433		NA											11	33					0	0	0	0
EIF3A	8661	broad.mit.edu	37	10	120801689	120801689	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:120801689C>T	uc001ldu.2	-	19	3489	c.3343G>A	c.(3343-3345)GAT>AAT	p.D1115N	EIF3A_uc010qsu.1_Missense_Mutation_p.D1081N|EIF3A_uc009xzg.1_Missense_Mutation_p.D154N	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1115	20.|Asp-rich.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CCTCGATCATCATCCAACCCT	0.602		NA											25	131					0	0	0	0
TACC2	10579	broad.mit.edu	37	10	123844325	123844325	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr10:123844325G>C	uc001lfv.2	+	4	2670	c.2310G>C	c.(2308-2310)TCG>TCC	p.S770S	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.S770S|TACC2_uc010qtv.1_Silent_p.S770S	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	770						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GTGATGCGTCGAGACAGGAAT	0.607		NA											16	79					0	0	0	0
PHRF1	57661	broad.mit.edu	37	11	587351	587351	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:587351G>A	uc001lqe.2	+	4	438	c.307G>A	c.(307-309)GAT>AAT	p.D103N	PHRF1_uc010qwc.1_Missense_Mutation_p.D103N|PHRF1_uc010qwd.1_Missense_Mutation_p.D102N|PHRF1_uc010qwe.1_Missense_Mutation_p.D99N	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	103							RNA polymerase binding|zinc ion binding				0						CAATTCTGATGATGATGCAGA	0.557		NA											10	36					0	0	0	0
PHRF1	57661	broad.mit.edu	37	11	587453	587453	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:587453G>A	uc001lqe.2	+	4	540	c.409G>A	c.(409-411)GAA>AAA	p.E137K	PHRF1_uc010qwc.1_Missense_Mutation_p.E137K|PHRF1_uc010qwd.1_Missense_Mutation_p.E136K|PHRF1_uc010qwe.1_Missense_Mutation_p.E133K	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	137	RING-type; degenerate.						RNA polymerase binding|zinc ion binding				0						CTGCATTGTCGAATGGTCCAA	0.562		NA											9	54					0	0	0	0
LRDD	55367	broad.mit.edu	37	11	801315	801315	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:801315C>G	uc001lro.1	-	9	1675	c.1533G>C	c.(1531-1533)GAG>GAC	p.E511D	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.E511D|LRDD_uc001lrl.1_Missense_Mutation_p.E365D|LRDD_uc001lrm.1_Missense_Mutation_p.E198D|LRDD_uc001lrn.1_Missense_Mutation_p.E365D|LRDD_uc001lrp.1_Missense_Mutation_p.E149D	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	511	ZU5 2.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCACTGCAGCCTCTGGTTCTC	0.697		NA											5	14					0	0	0	0
TRPM5	29850	broad.mit.edu	37	11	2433448	2433448	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:2433448C>T	uc001lwm.3	-	16	2400	c.2391G>A	c.(2389-2391)AAG>AAA	p.K797K	TRPM5_uc010qxl.1_Silent_p.K797K|TRPM5_uc009ydn.2_Silent_p.K799K	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	797	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTGTGAACTTCTTCACCAGGT	0.597		NA											29	104					0	0	0	0
RPS13	6207	broad.mit.edu	37	11	17098993	17098993	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:17098993G>C	uc001mmp.2	-	2	87	c.55C>G	c.(55-57)CGA>GGA	p.R19G		NM_001017	NP_001008	P62277	RS13_HUMAN	ribosomal protein S13	19					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome				0						ACGCTGCGTCGATAGGGTAAA	0.632		NA											6	22					0	0	0	0
AMBRA1	55626	broad.mit.edu	37	11	46564069	46564069	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:46564069G>A	uc010rgu.1	-	7	1858	c.1498C>T	c.(1498-1500)CAG>TAG	p.Q500*	AMBRA1_uc010rgt.1_Nonsense_Mutation_p.Q66*|AMBRA1_uc009ylc.1_Nonsense_Mutation_p.Q500*|AMBRA1_uc001ncu.1_Nonsense_Mutation_p.Q410*|AMBRA1_uc001ncv.2_Nonsense_Mutation_p.Q410*|AMBRA1_uc001ncw.2_Nonsense_Mutation_p.Q410*|AMBRA1_uc001ncx.2_Nonsense_Mutation_p.Q500*	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	500					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AGGTCACACTGAAGCTCATGG	0.567		NA											15	67					0	0	0	0
AMBRA1	55626	broad.mit.edu	37	11	46564092	46564092	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:46564092G>C	uc010rgu.1	-	7	1835	c.1475C>G	c.(1474-1476)TCG>TGG	p.S492W	AMBRA1_uc010rgt.1_Missense_Mutation_p.S58W|AMBRA1_uc009ylc.1_Missense_Mutation_p.S492W|AMBRA1_uc001ncu.1_Missense_Mutation_p.S402W|AMBRA1_uc001ncv.2_Missense_Mutation_p.S402W|AMBRA1_uc001ncw.2_Missense_Mutation_p.S402W|AMBRA1_uc001ncx.2_Missense_Mutation_p.S492W	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	492					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AATGCTGCCCGAGTTGTTTTG	0.562		NA											15	72					0	0	0	0
GIF	2694	broad.mit.edu	37	11	59604756	59604756	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:59604756G>C	uc001noi.2	-	6	810	c.762C>G	c.(760-762)CTC>CTG	p.L254L		NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	254					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						TAATCTCATTGAGTATCATAT	0.463		NA											13	53					0	0	0	0
MS4A6E	245802	broad.mit.edu	37	11	60107353	60107353	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:60107353G>C	uc001npd.2	+	3	383	c.369G>C	c.(367-369)CTG>CTC	p.L123L		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	123	Helical; (Potential).					integral to membrane	receptor activity				0						CTCTGTCTCTGATGCTGGTTT	0.483		NA											27	173					0	0	0	0
SLC25A45	283130	broad.mit.edu	37	11	65147398	65147398	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:65147398C>G	uc001odp.1	-	3	515	c.93G>C	c.(91-93)CAG>CAC	p.Q31H	SLC25A45_uc009yqi.1_Missense_Mutation_p.Q31H|SLC25A45_uc001odq.1_Intron|SLC25A45_uc001odr.1_Missense_Mutation_p.Q31H|SLC25A45_uc001ods.1_5'UTR|SLC25A45_uc001odt.1_5'UTR	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	31	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TGGTCTGGGTCTGCAGCCTCA	0.632		NA											6	38					0	0	0	0
CTSW	1521	broad.mit.edu	37	11	65649791	65649791	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:65649791C>T	uc001ogc.1	+	4	474	c.432C>T	c.(430-432)ATC>ATT	p.I144I	CTSW_uc001ogb.1_Silent_p.I144I	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	144					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		TCTCACCCATCAAGGACCAGG	0.612		NA											10	45					0	0	0	0
CTSW	1521	broad.mit.edu	37	11	65650706	65650706	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:65650706C>G	uc001ogc.1	+	9	873	c.831C>G	c.(829-831)ATC>ATG	p.I277M	CTSW_uc001ogb.1_Missense_Mutation_p.I277M	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	277					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		AAGGTGTGATCAAGGCCACAC	0.617		NA											17	71					0	0	0	0
GPR152	390212	broad.mit.edu	37	11	67220094	67220094	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:67220094G>A	uc001olm.2	-	1	107	c.102C>T	c.(100-102)GTC>GTT	p.V34V	uc009yrw.1_RNA|CABP4_uc001oln.2_5'UTR|CABP4_uc001olo.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	34	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CCACCAGGAAGACCGTGTCCC	0.667		NA											6	14					0	0	0	0
TBX10	347853	broad.mit.edu	37	11	67399081	67399081	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:67399081G>A	uc001omp.2	-	8	1241	c.1153C>T	c.(1153-1155)CAG>TAG	p.Q385*	NUDT8_uc001omn.2_5'Flank|NUDT8_uc001omo.1_5'Flank	NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	385					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TGGCATCACTGGGAGTCCTGG	0.672		NA											4	9					0	0	0	0
DNAJB13	374407	broad.mit.edu	37	11	73675980	73675980	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:73675980G>C	uc001ouo.2	+	4	1143	c.392G>C	c.(391-393)CGA>CCA	p.R131P		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	131					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					CTCCAGGGCCGAGGGGTCAAG	0.498		NA									OREG0021218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	61					0	0	0	0
ME3	10873	broad.mit.edu	37	11	86153891	86153891	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:86153891C>T	uc001pbz.2	-	13	1879	c.1625G>A	c.(1624-1626)CGA>CAA	p.R542Q	ME3_uc001pca.2_Missense_Mutation_p.R542Q|ME3_uc009yvk.2_Missense_Mutation_p.R542Q	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	542					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	AGACACGTCTCGGATGGTGCT	0.517		NA											12	68					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	100061931	100061931	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:100061931C>T	uc001pga.2	+	14	1993	c.1654C>T	c.(1654-1656)CGA>TGA	p.R552*	CNTN5_uc009ywv.1_Nonsense_Mutation_p.R552*|CNTN5_uc001pfz.2_Nonsense_Mutation_p.R552*|CNTN5_uc001pgb.2_Nonsense_Mutation_p.R478*|CNTN5_uc010ruk.1_5'UTR	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	552	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTACGTTTGCCGAGGGGAAAA	0.393		NA											10	36					0	0	0	0
ATM	472	broad.mit.edu	37	11	108106437	108106437	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:108106437C>T	uc001pkb.1	+	5	757	c.372C>T	c.(370-372)ATC>ATT	p.I124I	ATM_uc009yxr.1_Silent_p.I124I	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	124					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TAAATTATATCATGGATACAG	0.313		NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			15	42					0	0	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111636039	111636039	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:111636039C>T	uc001plx.1	-	2	268	c.184G>A	c.(184-186)GAA>AAA	p.E62K	PPP2R1B_uc001plw.1_Missense_Mutation_p.E62K|PPP2R1B_uc010rwi.1_Intron|PPP2R1B_uc010rwj.1_5'UTR|PPP2R1B_uc010rwk.1_Missense_Mutation_p.E62K|PPP2R1B_uc010rwl.1_Missense_Mutation_p.E62K	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	62	HEAT 2.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		GGCAACAATTCACTTCGGGTC	0.363		NA											12	81					0	0	0	0
BCO2	83875	broad.mit.edu	37	11	112071361	112071361	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:112071361C>T	uc001pnf.2	+	7	1008	c.891C>T	c.(889-891)TTC>TTT	p.F297F	BCO2_uc001pne.1_Silent_p.F124F|BCO2_uc001png.2_Silent_p.F224F|BCO2_uc001pnh.2_Silent_p.F263F|BCO2_uc010rwt.1_Silent_p.F192F|BCO2_uc009yyn.2_Silent_p.F263F|BCO2_uc001pni.2_Silent_p.F263F	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	297					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ATATAATTTTCATTGAACAAC	0.383		NA											13	57					0	0	0	0
DDX6	1656	broad.mit.edu	37	11	118633977	118633977	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:118633977G>T	uc001pub.2	-	7	1046	c.685C>A	c.(685-687)CTT>ATT	p.L229I	DDX6_uc001puc.2_Missense_Mutation_p.L229I	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	229	Helicase ATP-binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		TTCTTAATAAGATCCAGGATT	0.368		NA	T	IGH@	B-NHL								17	121					1.68e-08	1.78e-08	1	0
NTM	50863	broad.mit.edu	37	11	131781512	131781512	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr11:131781512C>T	uc001qgp.2	+	1	801	c.137C>T	c.(136-138)ACG>ATG	p.T46M	NTM_uc001qgm.2_Missense_Mutation_p.T46M|NTM_uc010sch.1_Missense_Mutation_p.T37M|NTM_uc010sci.1_Missense_Mutation_p.T46M|NTM_uc010scj.1_Missense_Mutation_p.T5M|NTM_uc001qgo.2_Missense_Mutation_p.T46M|NTM_uc001qgq.2_Missense_Mutation_p.T46M	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	46	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GACAACGTGACGGTCCGGCAG	0.617		NA									OREG0021537	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	84					0	0	0	0
WNK1	65125	broad.mit.edu	37	12	996423	996423	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:996423C>T	uc001qio.3	+	20	5824	c.5317C>T	c.(5317-5319)CTA>TTA	p.L1773L	WNK1_uc001qip.3_Silent_p.L1526L|WNK1_uc001qir.3_Silent_p.L946L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1773					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AGCAGGTACTCTACCCAGCGA	0.483		NA											16	102					0	0	0	0
DYRK4	8798	broad.mit.edu	37	12	4721834	4721834	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:4721834C>T	uc001qmx.2	+	12	1431	c.1271C>T	c.(1270-1272)TCT>TTT	p.S424F	DYRK4_uc009zeh.1_Missense_Mutation_p.S539F|DYRK4_uc001qmy.1_Missense_Mutation_p.S424F|DYRK4_uc001qmz.1_Missense_Mutation_p.S138F|DYRK4_uc001qna.1_Missense_Mutation_p.S61F|DYRK4_uc010ser.1_Missense_Mutation_p.S61F	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	424						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			TTTTTCCCCTCTGAGACAAGG	0.522		NA											17	102					0	0	0	0
USP5	8078	broad.mit.edu	37	12	6966015	6966015	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:6966015G>A	uc001qri.3	+	6	788	c.729G>A	c.(727-729)CCG>CCA	p.P243P	USP5_uc001qrh.3_Silent_p.P243P	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	243	UBP-type.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						CAGGCTACCCGTTAGCTGTCA	0.537		NA											9	48					0	0	0	0
C1S	716	broad.mit.edu	37	12	7169796	7169796	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:7169796C>T	uc001qsj.2	+	6	742	c.23C>T	c.(22-24)TCA>TTA	p.S8L	C1S_uc001qsk.2_Missense_Mutation_p.S8L|C1S_uc001qsl.2_Missense_Mutation_p.S8L|C1S_uc009zfr.2_Intron|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	8					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GTCCTGTTTTCACTTTTGGCA	0.502		NA											9	69					0	0	0	0
TAS2R50	259296	broad.mit.edu	37	12	11138872	11138872	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:11138872C>T	uc001qzl.2	-	1	640	c.588G>A	c.(586-588)CTG>CTA	p.L196L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	196	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						AGATTAGCATCAGAAAAGATA	0.408		NA											23	132					0	0	0	0
PRB3	5544	broad.mit.edu	37	12	11420963	11420963	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:11420963G>A	uc001qzs.2	-	3	258	c.220C>T	c.(220-222)CGT>TGT	p.R74C	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	74	2.|10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TTTCCTGGACGAGGTGGGGGA	0.627		NA											49	386					0	0	0	0
ETV6	2120	broad.mit.edu	37	12	12043951	12043951	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:12043951G>A	uc001qzz.2	+	8	1604	c.1330G>A	c.(1330-1332)GAA>AAA	p.E444K	ETV6_uc001raa.1_Intron	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	444						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				GGAGCTGGATGAACAAATATA	0.527		NA	T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								29	145					0	0	0	0
DUSP16	80824	broad.mit.edu	37	12	12629840	12629840	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:12629840G>A	uc001rao.1	-	7	2557	c.1925C>T	c.(1924-1926)TCA>TTA	p.S642L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.S494L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	642					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CTCTTCCCGTGACCTGTTCTC	0.498		NA											36	205					0	0	0	0
ERP27	121506	broad.mit.edu	37	12	15090892	15090892	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:15090892G>C	uc001rco.2	-	2	210	c.189C>G	c.(187-189)TTC>TTG	p.F63L		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	63	Thioredoxin.					endoplasmic reticulum lumen				breast(1)	1						TAACCTGGAAGAAGCCTATGA	0.547		NA											15	118					0	0	0	0
ABCC9	10060	broad.mit.edu	37	12	22069956	22069956	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:22069956G>C	uc001rfi.1	-	4	508	c.488C>G	c.(487-489)TCA>TGA	p.S163*	ABCC9_uc001rfh.2_Nonsense_Mutation_p.S163*|ABCC9_uc001rfj.1_Nonsense_Mutation_p.S163*	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	163	Extracellular (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACGCAGGTTTGATATGTCCAA	0.418		NA											33	187					0	0	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30876222	30876222	+	Nonsense_Mutation	SNP	G	G	A	rs79465544		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:30876222G>A	uc001rji.1	-	11	2765	c.2014C>T	c.(2014-2016)CAA>TAA	p.Q672*	CAPRIN2_uc001rjf.1_Nonsense_Mutation_p.Q469*|CAPRIN2_uc001rjg.1_Nonsense_Mutation_p.Q339*|CAPRIN2_uc001rjh.1_Nonsense_Mutation_p.Q672*|CAPRIN2_uc001rjj.1_Nonsense_Mutation_p.Q339*|CAPRIN2_uc001rjk.3_Nonsense_Mutation_p.Q672*|CAPRIN2_uc001rjl.3_Nonsense_Mutation_p.Q672*|CAPRIN2_uc001rjm.1_Nonsense_Mutation_p.Q339*	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	672					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AAATCACTTTGACTGGACAGA	0.358		NA											7	71					0	0	0	0
DNM1L	10059	broad.mit.edu	37	12	32873662	32873662	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:32873662C>G	uc001rld.2	+	8	966	c.805C>G	c.(805-807)CTT>GTT	p.L269V	DNM1L_uc010skf.1_RNA|DNM1L_uc010skg.1_RNA|DNM1L_uc001rle.2_Missense_Mutation_p.L269V|DNM1L_uc001rlf.2_Missense_Mutation_p.L269V|DNM1L_uc010skh.1_Missense_Mutation_p.L335V|DNM1L_uc001rlg.2_Missense_Mutation_p.L335V|DNM1L_uc001rlh.2_Missense_Mutation_p.L322V|DNM1L_uc010ski.1_Missense_Mutation_p.L66V	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	269	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GTATGCTTTTCTTCAAAAGAA	0.343		NA											11	61					0	0	0	0
ABCD2	225	broad.mit.edu	37	12	39967597	39967597	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:39967597C>T	uc001rmb.2	-	9	2350	c.1924G>A	c.(1924-1926)GAT>AAT	p.D642N		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	642	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CCTTCGACATCAATGCTGACA	0.353		NA											7	71					0	0	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846363	43846363	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:43846363G>A	uc010skx.1	-	13	1896	c.1896C>T	c.(1894-1896)ATC>ATT	p.I632I		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	632	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GAATGCCACTGATGTCCAAAT	0.388		NA											7	36					0	0	0	0
HDAC7	51564	broad.mit.edu	37	12	48179624	48179624	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:48179624C>T	uc010slo.1	-	23	2812	c.2617G>A	c.(2617-2619)GCA>ACA	p.A873T	HDAC7_uc009zku.2_RNA|HDAC7_uc001rqe.2_Missense_Mutation_p.A307T|HDAC7_uc001rqj.3_Missense_Mutation_p.A836T|HDAC7_uc001rqk.3_Missense_Mutation_p.A856T|HDAC7_uc010slp.1_Missense_Mutation_p.A117T	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7 isoform a	834	Histone deacetylase.				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		AGCACCACTGCGCCTCCTGCC	0.602		NA											7	37					0	0	0	0
DNAJC22	79962	broad.mit.edu	37	12	49742881	49742881	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:49742881C>G	uc001rua.2	+	2	627	c.226C>G	c.(226-228)CTG>GTG	p.L76V	DNAJC22_uc001rub.2_Missense_Mutation_p.L76V	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	76					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						GACACCCCCTCTGAGTCCCAT	0.557		NA											18	123					0	0	0	0
KCNH3	23416	broad.mit.edu	37	12	49944103	49944103	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:49944103G>A	uc001ruh.1	+	10	2169	c.1909G>A	c.(1909-1911)GCC>ACC	p.A637T	KCNH3_uc010smj.1_Missense_Mutation_p.A577T	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	637	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CACCGTGCTCGCCATCCTAGG	0.622		NA											10	56					0	0	0	0
TMBIM6	7009	broad.mit.edu	37	12	50152485	50152485	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:50152485G>A	uc001rux.2	+	7	585	c.453G>A	c.(451-453)CTG>CTA	p.L151L	TMBIM6_uc010sml.1_Intron|TMBIM6_uc001ruy.2_Silent_p.L209L|TMBIM6_uc001ruz.2_Silent_p.L151L	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	151	Helical; (Potential).				apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						TGTCAGCCCTGAGCTTGTTGC	0.443		NA											21	79					0	0	0	0
TARBP2	6895	broad.mit.edu	37	12	53895890	53895890	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:53895890G>A	uc001sdo.2	+	2	633	c.145G>A	c.(145-147)GAC>AAC	p.D49N	MAP3K12_uc001sdm.1_5'Flank|MAP3K12_uc001sdn.1_5'Flank|TARBP2_uc009znb.2_Missense_Mutation_p.D49N|TARBP2_uc001sdp.2_Missense_Mutation_p.D28N|TARBP2_uc001sdq.2_5'UTR|TARBP2_uc001sdr.2_5'UTR|TARBP2_uc001sds.2_Missense_Mutation_p.D49N|TARBP2_uc001sdt.2_Missense_Mutation_p.D28N|TARBP2_uc001sdu.2_5'UTR|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	49	Sufficient for interaction with PRKRA.|DRBM 1.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						GCCTGTGTACGACCTTCTCAA	0.592		NA											13	55					0	0	0	0
STAT2	6773	broad.mit.edu	37	12	56737683	56737683	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:56737683C>T	uc001slc.2	-	23	2417	c.2339G>A	c.(2338-2340)GGA>GAA	p.G780E	STAT2_uc001slb.2_Missense_Mutation_p.G322E|STAT2_uc001sld.2_Missense_Mutation_p.G776E	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	780					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGATACAGGTCCTTGGTCTGG	0.458		NA											7	159					0	0	0	0
SLC26A10	65012	broad.mit.edu	37	12	58019209	58019209	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:58019209G>A	uc001spe.2	+	13	1801	c.1490G>A	c.(1489-1491)CGA>CAA	p.R497Q	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_Intron	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	497	STAS.					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					AGCCGATGTCGAGATGCTAGG	0.582		NA											8	36					0	0	0	0
THAP2	83591	broad.mit.edu	37	12	72068122	72068122	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:72068122C>A	uc001swq.2	+	2	717	c.211C>A	c.(211-213)CTT>ATT	p.L71I		NM_031435	NP_113623	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated	71	THAP-type.					nucleolus	DNA binding|metal ion binding			ovary(1)	1						AACTCGACGACTTAAAATGGA	0.368		NA											15	69					2.32e-05	2.42e-05	1	0
TPH2	121278	broad.mit.edu	37	12	72335507	72335507	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:72335507C>G	uc009zrw.1	+	2	390	c.249C>G	c.(247-249)CTC>CTG	p.L83L	TPH2_uc001swy.2_5'UTR	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	83	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CACTGAGGCTCTTTCAGGTGA	0.403		NA											9	94					0	0	0	0
KCNC2	3747	broad.mit.edu	37	12	75437009	75437009	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:75437009G>A	uc001sxg.1	-	5	2337	c.1793C>T	c.(1792-1794)TCC>TTC	p.S598F	KCNC2_uc009zry.2_Intron|KCNC2_uc001sxe.2_Intron|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Missense_Mutation_p.S543F	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	598	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						TAAGCTTCGGGATTTTTCATA	0.433		NA											5	42					0	0	0	0
HSP90B1	7184	broad.mit.edu	37	12	104336982	104336982	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:104336982C>G	uc001tkb.1	+	13	1880	c.1775C>G	c.(1774-1776)GCC>GGC	p.A592G	HSP90B1_uc010swg.1_Missense_Mutation_p.A257G|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	592					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	CAGAATGTTGCCAAGGAAGGA	0.418		NA											11	68					0	0	0	0
PWP1	11137	broad.mit.edu	37	12	108091362	108091362	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:108091362G>C	uc001tmo.1	+	7	819	c.732G>C	c.(730-732)AAG>AAC	p.K244N	PWP1_uc001tmn.1_RNA|PWP1_uc009zuu.1_Missense_Mutation_p.K244N	NM_007062	NP_008993	Q13610	PWP1_HUMAN	periodic tryptophan protein 1	244					transcription, DNA-dependent	nucleus					0						AGAAGAAAAAGAAAGGAAAGA	0.378		NA											11	24					0	0	0	0
TRPV4	59341	broad.mit.edu	37	12	110252302	110252302	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:110252302C>T	uc001tpj.1	-	1	395	c.300G>A	c.(298-300)AAG>AAA	p.K100K	TRPV4_uc001tpg.1_Silent_p.K66K|TRPV4_uc001tph.1_Silent_p.K100K|TRPV4_uc001tpi.1_Silent_p.K100K|TRPV4_uc001tpk.1_Silent_p.K100K|TRPV4_uc001tpl.1_Silent_p.K100K	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	100	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TGGGTGCTTTCTTGGGCCCAG	0.552		NA											8	40					0	0	0	0
CUX2	23316	broad.mit.edu	37	12	111776184	111776184	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:111776184G>A	uc001tsa.1	+	20	3444	c.3291G>A	c.(3289-3291)CTG>CTA	p.L1097L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1097	CUT 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						AGCTGAGCCTGAAGGGGCGGG	0.592		NA											13	49					0	0	0	0
FBXO21	23014	broad.mit.edu	37	12	117627050	117627050	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:117627050C>G	uc001twk.2	-	2	396	c.357G>C	c.(355-357)AAG>AAC	p.K119N	FBXO21_uc001twj.2_Missense_Mutation_p.K119N|FBXO21_uc009zwq.2_Missense_Mutation_p.K119N	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	119					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		AAAAGAACCTCTTTGAGAACG	0.488		NA											13	85					0	0	0	0
CIT	11113	broad.mit.edu	37	12	120204897	120204897	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:120204897C>G	uc001txi.1	-	18	2225	c.2172G>C	c.(2170-2172)AAG>AAC	p.K724N	CIT_uc001txh.1_Missense_Mutation_p.K258N|CIT_uc001txj.1_Missense_Mutation_p.K766N	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	724	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTACTTTAATCTTTTCCTCAT	0.488		NA											30	164					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123804454	123804454	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:123804454C>G	uc010tap.1	-	19	2792	c.2792G>C	c.(2791-2793)GGA>GCA	p.G931A	SBNO1_uc010tao.1_Missense_Mutation_p.G930A|SBNO1_uc010taq.1_Intron	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	931							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TACCTTATCTCCATCCATAAA	0.338		NA											6	41					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123805101	123805101	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:123805101C>T	uc010tap.1	-	18	2545	c.2545G>A	c.(2545-2547)GAA>AAA	p.E849K	SBNO1_uc010tao.1_Missense_Mutation_p.E848K|SBNO1_uc010taq.1_Intron	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	849	Potential.						ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TGAGCCCTTTCCACAGCATCC	0.383		NA											30	118					0	0	0	0
SBNO1	55206	broad.mit.edu	37	12	123810101	123810101	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:123810101C>T	uc010tap.1	-	14	1921	c.1921G>A	c.(1921-1923)GAA>AAA	p.E641K	SBNO1_uc010tao.1_Missense_Mutation_p.E640K|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.E641K|SBNO1_uc001ueu.2_Missense_Mutation_p.E640K|SBNO1_uc001uev.2_Missense_Mutation_p.E639K|SBNO1_uc009zxy.1_Missense_Mutation_p.E606K	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	641							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TCCAAAGCTTCTAATGTTCTA	0.343		NA											31	204					0	0	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558534	129558534	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:129558534C>A	uc009zyl.1	-	9	3514	c.3186G>T	c.(3184-3186)AGG>AGT	p.R1062S	TMEM132D_uc001uia.2_Missense_Mutation_p.R600S	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	1062	Cytoplasmic (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CGATGGAGTTCCTGGTGGGGT	0.517		NA											23	111					2.4e-15	2.57e-15	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184842	130184842	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:130184842C>T	uc009zyl.1	-	2	809	c.481G>A	c.(481-483)GCC>ACC	p.A161T		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	161	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCTCCCCGGCGCTGCGGTCG	0.642		NA											3	22					0	0	0	0
ULK1	8408	broad.mit.edu	37	12	132404537	132404537	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:132404537G>A	uc001uje.2	+	26	3085	c.2817G>A	c.(2815-2817)CTG>CTA	p.L939L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	939					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TGCGCAGGCTGAATGAGCTGT	0.647		NA											5	44					0	0	0	0
EP400	57634	broad.mit.edu	37	12	132498089	132498089	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:132498089C>T	uc001ujn.2	+	17	3701	c.3666C>T	c.(3664-3666)CTC>CTT	p.L1222L	EP400_uc001ujl.2_Silent_p.L1221L|EP400_uc001ujm.2_Silent_p.L1222L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1258	Interactions with RUVBL1 and RUVBL2.|Helicase ATP-binding.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCCTGGAGCTCTGGACCATGG	0.572		NA											13	86					0	0	0	0
GOLGA3	2802	broad.mit.edu	37	12	133358996	133358996	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:133358996C>T	uc001ukz.1	-	17	3910	c.3351G>A	c.(3349-3351)GAG>GAA	p.E1117E	GOLGA3_uc001ula.1_Silent_p.E1117E	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1117	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTTCCCTTTCTCGTGCTCTA	0.493		NA											33	157					0	0	0	0
ATP12A	479	broad.mit.edu	37	13	25263408	25263408	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:25263408G>A	uc001upp.2	+	5	628	c.441G>A	c.(439-441)TTG>TTA	p.L147L	ATP12A_uc010aaa.2_Silent_p.L147L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	147	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGGTGTACTTGGGCTGTGTGC	0.532		NA											19	187					0	0	0	0
C13orf23	80209	broad.mit.edu	37	13	39588581	39588581	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:39588581G>C	uc001uwy.2	-	11	1681	c.808C>G	c.(808-810)CCT>GCT	p.P270A	C13orf23_uc001uwz.2_Missense_Mutation_p.P248A	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	270	Pro-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GAACCATGAGGAGAAAAGAGT	0.433		NA											5	31					0	0	0	0
FNDC3A	22862	broad.mit.edu	37	13	49771891	49771891	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:49771891G>A	uc001vcm.2	+	21	2676	c.2371G>A	c.(2371-2373)GAA>AAA	p.E791K	FNDC3A_uc001vcn.2_Missense_Mutation_p.E791K|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.E735K	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	791	Fibronectin type-III 6.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		AGATGTCACTGAATATCGACT	0.388		NA											21	73					0	0	0	0
RBM26	64062	broad.mit.edu	37	13	79952987	79952987	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr13:79952987C>G	uc001vkz.2	-	2	141	c.127G>C	c.(127-129)GAC>CAC	p.D43H	RBM26_uc001vky.2_Missense_Mutation_p.D43H|RBM26_uc001vla.2_Missense_Mutation_p.D43H|RBM26_uc001vlc.1_Missense_Mutation_p.D43H	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	43					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TCACTTTTGTCTTTCTTTACC	0.328		NA											4	27					0	0	0	0
NPAS3	64067	broad.mit.edu	37	14	34145537	34145537	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:34145537G>A	uc001wru.2	+	6	743	c.679G>A	c.(679-681)GAG>AAG	p.E227K	NPAS3_uc001wrs.2_Missense_Mutation_p.E214K|NPAS3_uc001wrt.2_Missense_Mutation_p.E195K|NPAS3_uc001wrv.2_Missense_Mutation_p.E197K|NPAS3_uc001wrw.2_Missense_Mutation_p.E125K	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GGGCACTGCTGAGGACGGAGC	0.617		NA											9	43					0	0	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36143457	36143457	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:36143457C>T	uc001wti.2	-	23	3719	c.3328G>A	c.(3328-3330)GAT>AAT	p.D1110N	RALGAPA1_uc010amp.2_5'Flank|RALGAPA1_uc001wtj.2_Missense_Mutation_p.D1110N|RALGAPA1_uc010tpv.1_Missense_Mutation_p.D1123N|RALGAPA1_uc010tpw.1_Missense_Mutation_p.D1157N	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1110					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						GTCAGGTTATCAGTTGAAATG	0.318		NA											6	20					0	0	0	0
FANCM	57697	broad.mit.edu	37	14	45606317	45606317	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:45606317G>C	uc001wwd.3	+	2	653	c.554G>C	c.(553-555)AGA>ACA	p.R185T	FANCM_uc001wwc.2_Missense_Mutation_p.R185T|FANCM_uc010anf.2_Missense_Mutation_p.R185T|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	185	Helicase ATP-binding.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TGCAGTAAGAGAGTGCTTTTT	0.373		NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				8	63					0	0	0	0
FANCM	57697	broad.mit.edu	37	14	45644452	45644452	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:45644452C>G	uc001wwd.3	+	14	2594	c.2495C>G	c.(2494-2496)TCT>TGT	p.S832C	FANCM_uc010anf.2_Missense_Mutation_p.S806C|FANCM_uc001wwe.3_Missense_Mutation_p.S368C|FANCM_uc010ang.2_Missense_Mutation_p.S46C	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	832					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						GTGATAGAATCTGATGAAGAA	0.294		NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				10	33					0	0	0	0
FANCM	57697	broad.mit.edu	37	14	45665674	45665674	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:45665674C>T	uc001wwd.3	+	21	5739	c.5640C>T	c.(5638-5640)TTC>TTT	p.F1880F	FANCM_uc010anf.2_Silent_p.F1854F|FANCM_uc001wwe.3_Silent_p.F1416F|FANCM_uc010ang.2_Silent_p.F1129F	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1880	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						AGAACAAGTTCATTGAGCAGA	0.368		NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				17	71					0	0	0	0
NIN	51199	broad.mit.edu	37	14	51208379	51208379	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:51208379C>T	uc001wym.2	-	25	5560	c.5369G>A	c.(5368-5370)CGA>CAA	p.R1790Q	NIN_uc001wyi.2_Missense_Mutation_p.R1790Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.R1077Q|NIN_uc010tqp.1_Missense_Mutation_p.R1796Q|NIN_uc001wyo.2_Missense_Mutation_p.R1790Q|NIN_uc001wyn.2_5'Flank	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1790	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					CTGAGTCACTCGTAGGTCAGA	0.393		NA	T	PDGFRB	MPD								28	144					0	0	0	0
CDKN3	1033	broad.mit.edu	37	14	54875501	54875501	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:54875501G>C	uc001xap.2	+	4	301	c.187G>C	c.(187-189)GAT>CAT	p.D63H	CDKN3_uc001xar.2_Missense_Mutation_p.D23H|CDKN3_uc001xaq.2_Missense_Mutation_p.D63H|CDKN3_uc010aoi.1_RNA|CDKN3_uc001xas.1_Intron|CDKN3_uc010aoj.1_Intron	NM_005192	NP_005183	Q16667	CDKN3_HUMAN	cyclin-dependent kinase inhibitor 3 isoform 1	63					cell cycle arrest|G1/S transition of mitotic cell cycle|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	perinuclear region of cytoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0						TGTCCAAAAAGATACAGGTAG	0.279		NA											15	92					0	0	0	0
KIAA0586	9786	broad.mit.edu	37	14	58932685	58932685	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:58932685G>A	uc001xdv.3	+	14	2237	c.1964G>A	c.(1963-1965)AGA>AAA	p.R655K	KIAA0586_uc010trr.1_Missense_Mutation_p.R772K|KIAA0586_uc001xdt.3_Missense_Mutation_p.R687K|KIAA0586_uc001xdu.3_Missense_Mutation_p.R716K|KIAA0586_uc010trs.1_Missense_Mutation_p.R646K|KIAA0586_uc010trt.1_Missense_Mutation_p.R591K|KIAA0586_uc010tru.1_Missense_Mutation_p.R591K	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	655										ovary(1)	1						AGCCCAAGTAGAGAAATGCCT	0.358		NA											6	166					0	0	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65198093	65198093	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:65198093C>G	uc001xho.1	+	8	1133	c.864C>G	c.(862-864)CTC>CTG	p.L288L	PLEKHG3_uc001xhn.1_Silent_p.L232L|PLEKHG3_uc001xhp.2_Silent_p.L288L|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	288					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TTCAGTCACTCCTCATCAACT	0.602		NA											5	33					0	0	0	0
RBM25	58517	broad.mit.edu	37	14	73566393	73566393	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:73566393G>T	uc001xno.2	+	9	1010	c.802G>T	c.(802-804)GAA>TAA	p.E268*	RBM25_uc001xnn.3_Nonsense_Mutation_p.E268*|RBM25_uc010ttu.1_Nonsense_Mutation_p.E268*|RBM25_uc001xnp.2_Nonsense_Mutation_p.E63*	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	268					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		AAATGCTATAGAAATGGAAGA	0.348		NA											18	90					1.5e-11	1.6e-11	1	0
HEATR4	399671	broad.mit.edu	37	14	73989358	73989358	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:73989358G>A	uc010tub.1	-	3	821	c.499C>T	c.(499-501)CAT>TAT	p.H167Y	HEATR4_uc010tua.1_Missense_Mutation_p.H120Y	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		ATGCAGGGATGATGGATGAGA	0.562		NA											9	46					0	0	0	0
NEK9	91754	broad.mit.edu	37	14	75568401	75568401	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:75568401C>T	uc001xrl.2	-	15	1953	c.1799G>A	c.(1798-1800)CGT>CAT	p.R600H	NEK9_uc001xrk.2_Missense_Mutation_p.R100H	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	600	RCC1 4.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		GGCAATGGTACGGATCTTATA	0.413		NA											17	146					0	0	0	0
ALKBH1	8846	broad.mit.edu	37	14	78146284	78146284	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:78146284C>T	uc001xuc.1	-	4	494	c.485G>A	c.(484-486)CGA>CAA	p.R162Q	ALKBH1_uc001xud.1_RNA	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog	162					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CAGTAAACTTCGGGGTCTCCG	0.398		NA											15	94					0	0	0	0
FAM181A	90050	broad.mit.edu	37	14	94394757	94394757	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:94394757G>A	uc001ybz.1	+	3	619	c.312G>A	c.(310-312)CAG>CAA	p.Q104Q	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.Q42Q|FAM181A_uc001yca.1_Silent_p.Q42Q	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	104											0						AGTACCTGCAGAAGCAGCTCA	0.632		NA											5	22					0	0	0	0
MTA1	9112	broad.mit.edu	37	14	105936499	105936499	+	Missense_Mutation	SNP	C	C	T	rs146041220	byFrequency	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr14:105936499C>T	uc001yqx.2	+	21	2282	c.2095C>T	c.(2095-2097)CGG>TGG	p.R699W	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Missense_Mutation_p.R464W|CRIP2_uc010tyr.1_5'Flank|CRIP2_uc001yrc.2_5'Flank	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	699	Poly-Pro.|SH3-binding (Potential).				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CCTGCCGCCGCGGCCACCGCC	0.567		NA											5	17					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28413555	28413555	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:28413555C>G	uc001zbj.2	-	67	10517	c.10411G>C	c.(10411-10413)GAG>CAG	p.E3471Q		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3471					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCTTTTACCTCTCTCTTTTCT	0.428		NA											25	125					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28459835	28459835	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:28459835G>A	uc001zbj.2	-	40	6430	c.6324C>T	c.(6322-6324)CTC>CTT	p.L2108L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2108					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCAGGTAGTGAGCAAGCTTC	0.562		NA											5	22					0	0	0	0
TRPM1	4308	broad.mit.edu	37	15	31323259	31323259	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:31323259C>T	uc001zfm.2	-	22	3116	c.2988G>A	c.(2986-2988)TGG>TGA	p.W996*	TRPM1_uc010azy.2_Nonsense_Mutation_p.W903*|TRPM1_uc001zfl.2_Intron	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	996	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGGCCAGTTTCCAAGAGGGCT	0.478		NA											12	99					0	0	0	0
FMN1	342184	broad.mit.edu	37	15	33359906	33359906	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:33359906G>A	uc001zhf.3	-	1	180	c.180C>T	c.(178-180)TTC>TTT	p.F60F	FMN1_uc001zhg.2_Silent_p.F60F	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CTAAACTATGGAATGCTTTCA	0.453		NA											10	71					0	0	0	0
C15orf55	256646	broad.mit.edu	37	15	34648777	34648777	+	Silent	SNP	C	C	T	rs137916466		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:34648777C>T	uc001zif.2	+	7	2639	c.2484C>T	c.(2482-2484)ACC>ACT	p.T828T	C15orf55_uc010ucc.1_Silent_p.T856T|C15orf55_uc010ucd.1_Silent_p.T846T	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	828						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GCTGTGAAACCGTAGGGCATC	0.507		NA	T	BRD3|BRD4	lethal midline carcinoma								11	60					0	0	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42110227	42110227	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:42110227G>C	uc001zok.3	+	18	2229	c.1943G>C	c.(1942-1944)GGA>GCA	p.G648A	MAPKBP1_uc001zoj.3_Missense_Mutation_p.G642A|MAPKBP1_uc010bcj.2_Missense_Mutation_p.G149A|MAPKBP1_uc010bci.2_Missense_Mutation_p.G642A|MAPKBP1_uc010udb.1_Missense_Mutation_p.G481A|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.G149A	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	648	WD 10.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ATCAGCAGTGGAAAGCAGAAG	0.517		NA											28	140					0	0	0	0
TGM5	9333	broad.mit.edu	37	15	43552604	43552604	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:43552604C>G	uc001zrd.1	-	2	192	c.184G>C	c.(184-186)GAA>CAA	p.E62Q	TGM5_uc001zre.1_Missense_Mutation_p.E62Q	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	62					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TTACCAGTTTCAACCACGAAG	0.597		NA											5	49					0	0	0	0
MAP1A	4130	broad.mit.edu	37	15	43814069	43814069	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:43814069G>C	uc001zrt.2	+	4	865	c.398G>C	c.(397-399)GGA>GCA	p.G133A		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	133						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCTGAGCTTGGAGTTGTCTTT	0.557		NA											13	51					0	0	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43827592	43827592	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:43827592G>A	uc001zrw.2	-	31	3765	c.3582C>T	c.(3580-3582)TTC>TTT	p.F1194F	PPIP5K1_uc001zrx.1_Silent_p.F1167F|PPIP5K1_uc001zru.2_Silent_p.F1169F|PPIP5K1_uc001zry.3_Silent_p.F1169F|PPIP5K1_uc001zrv.2_Intron	NM_001130858	NP_001124330	Q6PFW1	VIP1_HUMAN	histidine acid phosphatase domain containing 2A	1194					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity				0						GTTGATCACTGAAGCCAAATT	0.522		NA											16	85					0	0	0	0
DMXL2	23312	broad.mit.edu	37	15	51790872	51790872	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:51790872G>A	uc002abf.2	-	18	4774	c.4549C>T	c.(4549-4551)CAT>TAT	p.H1517Y	DMXL2_uc010ufy.1_Missense_Mutation_p.H1517Y|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1517						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TGCATAAGATGACTTGAAAGT	0.408		NA											19	46					0	0	0	0
THSD4	79875	broad.mit.edu	37	15	71535293	71535293	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:71535293C>T	uc002atb.1	+	4	849	c.770C>T	c.(769-771)TCA>TTA	p.S257L	THSD4_uc002atd.1_5'UTR	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	257	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						CCTGCAGCTTCAAGTCTCTTT	0.562		NA											17	64					0	0	0	0
C15orf27	123591	broad.mit.edu	37	15	76496185	76496185	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:76496185C>G	uc002bbq.2	+	11	1280	c.1125C>G	c.(1123-1125)CTC>CTG	p.L375L	C15orf27_uc010bkp.2_Silent_p.L191L|C15orf27_uc002bbr.2_Silent_p.L191L|C15orf27_uc002bbs.2_Silent_p.L53L	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	375						integral to membrane					0						ACATGCCCCTCAAACTCGGCG	0.632		NA											23	103					0	0	0	0
C15orf27	123591	broad.mit.edu	37	15	76496280	76496280	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:76496280C>T	uc002bbq.2	+	11	1375	c.1220C>T	c.(1219-1221)TCC>TTC	p.S407F	C15orf27_uc010bkp.2_Missense_Mutation_p.S223F|C15orf27_uc002bbr.2_Missense_Mutation_p.S223F|C15orf27_uc002bbs.2_Missense_Mutation_p.S85F	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	407						integral to membrane					0						ACGCTGGGCTCCTCCATGGAC	0.697		NA											9	30					0	0	0	0
IL16	3603	broad.mit.edu	37	15	81575003	81575003	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:81575003G>A	uc002bgh.3	+	9	1481	c.1105G>A	c.(1105-1107)GGC>AGC	p.G369S	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.G369S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.G411S|IL16_uc002bgg.2_Missense_Mutation_p.G369S|IL16_uc002bgi.1_5'UTR	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	369	PDZ 2.|Interaction with GRIN2A.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CCTGGGCATCGGCCTGTGCAG	0.642		NA											26	125					0	0	0	0
ALPK3	57538	broad.mit.edu	37	15	85406114	85406114	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:85406114C>T	uc002ble.2	+	10	5151	c.4984C>T	c.(4984-4986)CTT>TTT	p.L1662F	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1662	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGAGACTTCTCTTGTGGGCAG	0.557		NA											17	95					0	0	0	0
ALPK3	57538	broad.mit.edu	37	15	85406847	85406847	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:85406847C>T	uc002ble.2	+	11	5248	c.5081C>T	c.(5080-5082)GCG>GTG	p.A1694V	ALPK3_uc010upc.1_5'Flank	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1694	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCCGGGCCGCGCCTGGCTTT	0.557		NA											6	21					0	0	0	0
AEN	64782	broad.mit.edu	37	15	89173347	89173347	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:89173347G>A	uc002bmt.2	+	4	951	c.800G>A	c.(799-801)CGG>CAG	p.R267Q	AEN_uc010bnm.1_Missense_Mutation_p.R267Q	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	267					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						GAGCTCTACCGGCTGGTGGAG	0.607		NA											8	42					0	0	0	0
LINS1	55180	broad.mit.edu	37	15	101109585	101109585	+	Missense_Mutation	SNP	C	C	T	rs148450316		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:101109585C>T	uc002bwe.2	-	8	2423	c.2132G>A	c.(2131-2133)AGA>AAA	p.R711K	LINS1_uc002bwd.2_Missense_Mutation_p.R298K|LINS1_uc002bwf.2_Missense_Mutation_p.R711K|LINS1_uc002bwg.2_Missense_Mutation_p.R711K|LINS1_uc002bwh.2_Missense_Mutation_p.R711K	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	711											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TTTTACTATTCTGTAAAATAT	0.383		NA											24	124					0	0	0	0
OR4F6	390648	broad.mit.edu	37	15	102346152	102346152	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr15:102346152C>T	uc010utr.1	+	1	230	c.230C>T	c.(229-231)ACA>ATA	p.T77I		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TGTTCCTCCACAGCTCCCAAG	0.463		NA											49	253					0	0	0	0
SOLH	6650	broad.mit.edu	37	16	599044	599044	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:599044G>A	uc002chi.2	+	5	1864	c.1501G>A	c.(1501-1503)GGC>AGC	p.G501S		NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	501	Calpain catalytic.				proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				CGAGTCTGTCGGCTTCCCCGC	0.657		NA											31	90					0	0	0	0
BAIAP3	8938	broad.mit.edu	37	16	1398119	1398119	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1398119C>T	uc002clk.1	+	33	3277	c.3277C>T	c.(3277-3279)CGC>TGC	p.R1093C	BAIAP3_uc002clj.2_Missense_Mutation_p.R1075C|BAIAP3_uc010uuz.1_Missense_Mutation_p.R1058C|BAIAP3_uc010uva.1_Missense_Mutation_p.R1030C|BAIAP3_uc010uvc.1_Missense_Mutation_p.R1022C	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	1093	C2 2.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				CGAGGCGTGCCGCCGCCGCGC	0.622		NA											7	33					0	0	0	0
C16orf42	115939	broad.mit.edu	37	16	1399439	1399439	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1399439C>T	uc002cll.2	-	6	1006	c.938G>A	c.(937-939)TGA>TAA	p.*313*	BAIAP3_uc002clj.2_3'UTR|BAIAP3_uc010uuz.1_3'UTR|BAIAP3_uc010uva.1_3'UTR|BAIAP3_uc002clk.1_3'UTR|BAIAP3_uc010uvc.1_3'UTR|GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	313					rRNA processing						0		Hepatocellular(780;0.0893)				CTGCAACCCTCAGTCTCTCTG	0.567		NA											39	322					0	0	0	0
C16orf42	115939	broad.mit.edu	37	16	1399524	1399524	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1399524C>T	uc002cll.2	-	6	921	c.853G>A	c.(853-855)GAA>AAA	p.E285K	GNPTG_uc002clm.2_5'Flank	NM_001001410	NP_001001410	Q9UJK0	TSR3_HUMAN	hypothetical protein LOC115939	285					rRNA processing						0		Hepatocellular(780;0.0893)				TGCTCCTCTTCACAGCAGCTG	0.652		NA											36	214					0	0	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1816351	1816351	+	Silent	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:1816351C>A	uc002cmk.2	+	22	2877	c.2757C>A	c.(2755-2757)CTC>CTA	p.L919L	MAPK8IP3_uc002cml.2_Silent_p.L913L|MAPK8IP3_uc010uvl.1_Silent_p.L920L	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	919					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCGGGCCTCTCACAGAGCACG	0.687		NA											6	38					3.6e-05	3.75e-05	1	0
SRRM2	23524	broad.mit.edu	37	16	2811883	2811883	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:2811883G>T	uc002crk.2	+	11	1903	c.1354G>T	c.(1354-1356)GAG>TAG	p.E452*	SRRM2_uc002crj.1_Nonsense_Mutation_p.E356*|SRRM2_uc002crl.1_Nonsense_Mutation_p.E452*|SRRM2_uc010bsu.1_Nonsense_Mutation_p.E356*	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	452	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GTCCCACCGAGAGATTTCTTC	0.547		NA											19	207					1.56e-12	1.67e-12	1	0
CREBBP	1387	broad.mit.edu	37	16	3830809	3830809	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:3830809G>A	uc002cvv.2	-	8	1951	c.1747C>T	c.(1747-1749)CCT>TCT	p.P583S	CREBBP_uc002cvw.2_Missense_Mutation_p.P545S	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	583					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGCTAGAAGGAGGAGCTGCT	0.483		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				7	49					0	0	0	0
SEPT12	124404	broad.mit.edu	37	16	4835884	4835884	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:4835884C>A	uc002cxq.2	-	4	439	c.298G>T	c.(298-300)GAG>TAG	p.E100*	SEPT12_uc002cxr.2_Nonsense_Mutation_p.E100*|SEPT12_uc010bty.2_RNA|uc002cxt.2_5'Flank	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	100					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CCCTTCTCCTCTATGACTGTG	0.438		NA											9	78					0.00621372	0.00632932	1	0
GRIN2A	2903	broad.mit.edu	37	16	9943615	9943615	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:9943615G>C	uc002czo.3	-	5	1874	c.1326C>G	c.(1324-1326)ATC>ATG	p.I442M	GRIN2A_uc010uym.1_Missense_Mutation_p.I442M|GRIN2A_uc010uyn.1_Missense_Mutation_p.I285M|GRIN2A_uc002czr.3_Missense_Mutation_p.I442M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	442	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCACTCACTTGATTTTGACGA	0.493		NA											13	59					0	0	0	0
ABCC6	368	broad.mit.edu	37	16	16286777	16286777	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:16286777G>A	uc002den.3	-	11	1378	c.1341C>T	c.(1339-1341)CTC>CTT	p.L447L	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Silent_p.L459L	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	447	ABC transmembrane type-1 1.|Helical; Name=8; (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGGGCCCCAGGAGCTGGGGAT	0.438		NA											14	59					0	0	0	0
ZP2	7783	broad.mit.edu	37	16	21213295	21213295	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:21213295G>A	uc002dii.2	-	12	1337	c.1337C>T	c.(1336-1338)ACG>ATG	p.T446M	ZP2_uc010bwn.1_Missense_Mutation_p.T485M	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	446	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		AGGAAAATCCGTCCAGAGAGC	0.363		NA											17	81					0	0	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24950751	24950751	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:24950751G>A	uc002dnb.2	-	17	1751	c.1658C>T	c.(1657-1659)TCT>TTT	p.S553F	ARHGAP17_uc002dmy.2_5'Flank|ARHGAP17_uc002dmz.2_Missense_Mutation_p.S77F|ARHGAP17_uc002dna.2_Missense_Mutation_p.S280F|ARHGAP17_uc002dnc.2_Intron|ARHGAP17_uc010vcf.1_Intron	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	553	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CCCACCCCCAGAGCTGCTTTC	0.687		NA											5	25					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27495572	27495572	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:27495572G>A	uc002dov.1	-	25	4001	c.3961C>T	c.(3961-3963)CGC>TGC	p.R1321C	GTF3C1_uc002dou.2_Missense_Mutation_p.R1321C	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1321						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ACTATGTAGCGAGCTCTTCGT	0.488		NA											25	54					0	0	0	0
ZNF768	79724	broad.mit.edu	37	16	30537313	30537313	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:30537313C>T	uc002dyk.3	-	2	324	c.148G>A	c.(148-150)GAA>AAA	p.E50K	ZNF768_uc010vex.1_Missense_Mutation_p.E19K|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.E19K	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	50					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						TCTTCgacttcatagtcccca	0.408		NA											23	162					0	0	0	0
GPR114	221188	broad.mit.edu	37	16	57597888	57597888	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:57597888C>G	uc002elx.3	+	5	511	c.426C>G	c.(424-426)TTC>TTG	p.F142L	GPR114_uc010vhr.1_Missense_Mutation_p.F142L|GPR114_uc002ely.2_Missense_Mutation_p.F142L	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	142	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CCCACTTTTTCAAGGTCAGTG	0.637		NA											11	70					0	0	0	0
GPR114	221188	broad.mit.edu	37	16	57598964	57598964	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:57598964C>G	uc002elx.3	+	6	533	c.448C>G	c.(448-450)CTG>GTG	p.L150V	GPR114_uc010vhr.1_Missense_Mutation_p.L150V|GPR114_uc002ely.2_Missense_Mutation_p.L150V	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	150	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CAACTCATCTCTGCTGAATAA	0.567		NA											9	72					0	0	0	0
SLC38A7	55238	broad.mit.edu	37	16	58704061	58704061	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:58704061G>A	uc002eod.1	-	11	1635	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L	SLC38A7_uc002eob.1_RNA|SLC38A7_uc002eoc.1_Intron|SLC38A7_uc010vil.1_Silent_p.L325L	NM_018231	NP_060701	Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	414	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						TGGCTTGAATGAGGCACAGCC	0.557		NA											14	42					0	0	0	0
RLTPR	146206	broad.mit.edu	37	16	67680670	67680670	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67680670C>T	uc002etn.2	+	7	640	c.520C>T	c.(520-522)CGA>TGA	p.R174*	RLTPR_uc010cel.1_Nonsense_Mutation_p.R174*|RLTPR_uc010vjr.1_Nonsense_Mutation_p.R174*	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	174										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CTTCCCTTTCCGAGAGGAGAT	0.582		NA											10	90					0	0	0	0
THAP11	57215	broad.mit.edu	37	16	67876995	67876995	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67876995C>G	uc002euo.2	+	1	783	c.538C>G	c.(538-540)CCC>GCC	p.P180A	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		GCCCATCACTCCCACTGGAGA	0.647		NA											19	132					0	0	0	0
THAP11	57215	broad.mit.edu	37	16	67877127	67877127	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67877127C>T	uc002euo.2	+	1	915	c.670C>T	c.(670-672)CCT>TCT	p.P224S	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		TGCCGAGTGCCCTATGGGCCC	0.657		NA											7	68					0	0	0	0
PSMB10	5699	broad.mit.edu	37	16	67969349	67969349	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67969349C>T	uc002eux.1	-	6	633	c.532G>A	c.(532-534)GAA>AAA	p.E178K		NM_002801	NP_002792	P40306	PSB10_HUMAN	proteasome beta 10 subunit proprotein	178					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		AACCGGTCTTCTAGCACCGCC	0.647		NA											19	65					0	0	0	0
PSMB10	5699	broad.mit.edu	37	16	67970194	67970194	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:67970194C>A	uc002eux.1	-	3	267	c.166G>T	c.(166-168)GAT>TAT	p.D56Y		NM_002801	NP_002792	P40306	PSB10_HUMAN	proteasome beta 10 subunit proprotein	56					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		GCTCGCGTATCGGCGCCCAGA	0.632		NA											8	53					0.00307968	0.00314185	1	0
CDH3	1001	broad.mit.edu	37	16	68729708	68729708	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:68729708G>A	uc002ewf.2	+	15	3294	c.2162G>A	c.(2161-2163)GGT>GAT	p.G721D	CDH3_uc010vli.1_Missense_Mutation_p.G666D	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	721	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CTCCACCGAGGTCTGGAGGCC	0.602		NA											7	64					0	0	0	0
PMFBP1	83449	broad.mit.edu	37	16	72188118	72188118	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:72188118C>G	uc002fcc.3	-	4	578	c.406G>C	c.(406-408)GAA>CAA	p.E136Q	PMFBP1_uc002fcd.2_Missense_Mutation_p.E136Q|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_5'UTR	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	136										ovary(2)	2		Ovarian(137;0.179)				ACCTCATCTTCTTTCAGTTTG	0.463		NA											19	99					0	0	0	0
PKD1L2	114780	broad.mit.edu	37	16	81209259	81209259	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:81209259G>C	uc002fgh.1	-	15	2534	c.2534C>G	c.(2533-2535)TCT>TGT	p.S845C	PKD1L2_uc002fgg.1_RNA|PKD1L2_uc002fgi.2_Missense_Mutation_p.S160C|PKD1L2_uc002fgj.2_Missense_Mutation_p.S845C|PKD1L2_uc002fgk.1_5'UTR|PKD1L2_uc002fgl.1_Missense_Mutation_p.S101C	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	845	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATTGGTGGCAGAAATAACTAC	0.532		NA											14	61					0	0	0	0
SPG7	6687	broad.mit.edu	37	16	89597147	89597147	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:89597147C>T	uc002fnj.2	+	7	939	c.918C>T	c.(916-918)GTC>GTT	p.V306V	SPG7_uc002fni.2_Silent_p.V306V	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	306	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GGAAAGGAGTCAGCTTCAAAG	0.517		NA											8	79					0	0	0	0
FANCA	2175	broad.mit.edu	37	16	89877208	89877208	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:89877208C>G	uc002fou.1	-	5	471	c.429G>C	c.(427-429)AAG>AAC	p.K143N	FANCA_uc010vpn.1_Missense_Mutation_p.K143N|FANCA_uc002fov.1_Missense_Mutation_p.K126N|FANCA_uc002fow.1_Missense_Mutation_p.K143N|FANCA_uc002fox.1_Missense_Mutation_p.K143N|FANCA_uc010ciu.1_Intron|FANCA_uc002foy.2_Missense_Mutation_p.K143N	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	143					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		AAGACAGCTTCTTCTGAAAAG	0.348		NA	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				20	105					0	0	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4457189	4457189	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:4457189C>G	uc002fyb.3	-	5	539	c.477G>C	c.(475-477)TCG>TCC	p.S159S	MYBBP1A_uc002fxz.3_Silent_p.S159S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	159	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						GCAGCTTCACCGACTTCATCA	0.627		NA											4	19					0	0	0	0
SMTNL2	342527	broad.mit.edu	37	17	4510765	4510765	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:4510765C>T	uc002fyf.1	+	8	1436	c.1369C>T	c.(1369-1371)CTG>TTG	p.L457L	SMTNL2_uc002fye.2_Silent_p.L313L|uc002fyg.1_5'Flank	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	457											0				READ - Rectum adenocarcinoma(115;0.0325)		GTACAACCACCTGCGTCGCTT	0.617		NA											22	94					0	0	0	0
MIS12	79003	broad.mit.edu	37	17	5392414	5392414	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:5392414C>G	uc002gcd.2	+	2	561	c.232C>G	c.(232-234)CTT>GTT	p.L78V	DERL2_uc002gcc.1_5'Flank|MIS12_uc002gce.2_Missense_Mutation_p.L78V	NM_024039	NP_076944	Q9H081	MIS12_HUMAN	MIS12 homolog	78					cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding				0						TTTTGATAACCTTTTTAGCAA	0.403		NA											12	45					0	0	0	0
MFSD6L	162387	broad.mit.edu	37	17	8700953	8700953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:8700953G>A	uc002glp.1	-	1	1634	c.1486C>T	c.(1486-1488)CGA>TGA	p.R496*		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	496						integral to membrane				central_nervous_system(1)	1						AAGTGGCCTCGGAACAAGGCA	0.612		NA											9	32					0	0	0	0
NCOR1	9611	broad.mit.edu	37	17	15965063	15965063	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:15965063C>T	uc002gpo.2	-	37	5773	c.5533G>A	c.(5533-5535)GAA>AAA	p.E1845K	NCOR1_uc002gpn.2_Intron|NCOR1_uc002gpm.2_Missense_Mutation_p.E365K|NCOR1_uc010vwb.1_Missense_Mutation_p.E429K|NCOR1_uc010coy.2_Missense_Mutation_p.E753K|NCOR1_uc010vwc.1_Missense_Mutation_p.E655K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1845	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTGGCAGCTTCATGCTTACTC	0.507		NA											24	113					0	0	0	0
PEMT	10400	broad.mit.edu	37	17	17409126	17409126	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:17409126G>A	uc002grj.2	-	7	646	c.579C>T	c.(577-579)TCC>TCT	p.S193S	PEMT_uc002grk.2_Silent_p.S193S|PEMT_uc002grl.2_Silent_p.S230S|PEMT_uc010vwx.1_3'UTR	NM_148173	NP_680478	Q9UBM1	PEMT_HUMAN	phosphatidylethanolamine N-methyltransferase	193					cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity				0				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)		TGTGGGACCCGGAGGCTTTCT	0.672		NA											4	22					0	0	0	0
NLK	51701	broad.mit.edu	37	17	26518200	26518200	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:26518200G>A	uc010crj.2	+	9	1602	c.1390G>A	c.(1390-1392)GAT>AAT	p.D464N	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	464					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		TCCCAAATTTGATGACACTTT	0.428		NA											10	57					0	0	0	0
KIAA0100	9703	broad.mit.edu	37	17	26943185	26943185	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:26943185C>T	uc002hbu.2	-	37	6418	c.6319G>A	c.(6319-6321)GAG>AAG	p.E2107K	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.E436K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2107						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCAGCTCGCTCTTTCATCTTG	0.483		NA											4	56					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29161435	29161435	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161435G>C	uc002hfs.1	+	2	682	c.336G>C	c.(334-336)AAG>AAC	p.K112N	ATAD5_uc002hft.1_Missense_Mutation_p.K9N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	112					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGTTTAAGAAGAAAAGAAAGA	0.338		NA											15	136					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29161585	29161585	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161585G>C	uc002hfs.1	+	2	832	c.486G>C	c.(484-486)AAG>AAC	p.K162N	ATAD5_uc002hft.1_Missense_Mutation_p.K59N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	162					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TACGTTACAAGAAACAAGTAG	0.313		NA											16	197					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29161714	29161714	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161714G>C	uc002hfs.1	+	2	961	c.615G>C	c.(613-615)TTG>TTC	p.L205F	ATAD5_uc002hft.1_Missense_Mutation_p.L102F	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	205					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCAAAAAGTTGAGAAAAAGGA	0.328		NA											23	141					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29161793	29161793	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29161793G>C	uc002hfs.1	+	2	1040	c.694G>C	c.(694-696)GAT>CAT	p.D232H	ATAD5_uc002hft.1_Missense_Mutation_p.D129H	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	232					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GCTTAAAAAAGATGGTAAAGA	0.338		NA											16	126					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29162131	29162131	+	Silent	SNP	G	G	A	rs111343309	by1000genomes	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162131G>A	uc002hfs.1	+	2	1378	c.1032G>A	c.(1030-1032)TTG>TTA	p.L344L	ATAD5_uc002hft.1_Silent_p.L241L	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	344					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAATTTTCTTGAAACAAAAGC	0.378		NA											9	42					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29162199	29162199	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162199G>C	uc002hfs.1	+	2	1446	c.1100G>C	c.(1099-1101)AGA>ACA	p.R367T	ATAD5_uc002hft.1_Missense_Mutation_p.R264T	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	367					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GTTCAGAAAAGAAAATCTAAT	0.343		NA											11	50					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29162272	29162272	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162272G>A	uc002hfs.1	+	2	1519	c.1173G>A	c.(1171-1173)GTG>GTA	p.V391V	ATAD5_uc002hft.1_Silent_p.V288V	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	391					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CTGAAGCTGTGAAACCAAAAT	0.363		NA											15	72					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29162420	29162420	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162420G>A	uc002hfs.1	+	2	1667	c.1321G>A	c.(1321-1323)GAT>AAT	p.D441N	ATAD5_uc002hft.1_Missense_Mutation_p.D338N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	441					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGGAAGAGATGATAATTCTAA	0.323		NA											10	63					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29162726	29162726	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29162726G>A	uc002hfs.1	+	2	1973	c.1627G>A	c.(1627-1629)GAT>AAT	p.D543N	ATAD5_uc002hft.1_Missense_Mutation_p.D440N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	543					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGTTTATGAAGATATAGCAAA	0.289		NA											20	70					0	0	0	0
ATAD5	79915	broad.mit.edu	37	17	29164285	29164285	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:29164285G>A	uc002hfs.1	+	3	2375	c.2029G>A	c.(2029-2031)GAG>AAG	p.E677K	ATAD5_uc002hft.1_Missense_Mutation_p.E574K	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	677					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				caaaagatctgagaaaTCTGA	0.249		NA											11	51					0	0	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349317	30349317	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:30349317G>A	uc002hgu.2	+	1	1163	c.1152G>A	c.(1150-1152)CTG>CTA	p.L384L	LRRC37B_uc010wbx.1_Silent_p.L302L|LRRC37B_uc010csu.2_Silent_p.L384L	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	384	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CTACAGCCCTGAGGACTACAG	0.542		NA											33	193					0	0	0	0
LRRC37B	114659	broad.mit.edu	37	17	30376174	30376174	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:30376174G>A	uc002hgu.2	+	10	2448	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	LRRC37B_uc010wbx.1_Missense_Mutation_p.E731K|LRRC37B_uc010csu.2_Missense_Mutation_p.E762K	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	813	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CATCCCCAACGAGGATGTGAG	0.498		NA											22	105					0	0	0	0
SRCIN1	80725	broad.mit.edu	37	17	36704795	36704795	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:36704795C>G	uc002hqd.2	-	17	3493	c.3268G>C	c.(3268-3270)GAG>CAG	p.E1090Q	SRCIN1_uc002hqf.1_Missense_Mutation_p.E962Q|SRCIN1_uc002hqe.2_Missense_Mutation_p.E944Q	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	962					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						TGACCTACCTCTAGCTCTGCG	0.662		NA											11	58					0	0	0	0
SRCIN1	80725	broad.mit.edu	37	17	36704826	36704826	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:36704826C>T	uc002hqd.2	-	17	3462	c.3237G>A	c.(3235-3237)GAG>GAA	p.E1079E	SRCIN1_uc002hqf.1_Silent_p.E951E|SRCIN1_uc002hqe.2_Silent_p.E933E	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	951					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CCTCGTCATCCTCGTCCTTGA	0.667		NA											11	59					0	0	0	0
MLLT6	4302	broad.mit.edu	37	17	36876644	36876644	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:36876644G>C	uc002hqi.3	+	15	2188	c.2175G>C	c.(2173-2175)GCG>GCC	p.A725A	MLLT6_uc002hqj.2_Silent_p.A160A|MLLT6_uc002hqk.3_Silent_p.A56A	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	725					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					TGCTGAAGGCGCTGCACGCGC	0.433		NA	T	MLL	AL								4	24					0	0	0	0
PNMT	5409	broad.mit.edu	37	17	37826388	37826388	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:37826388G>C	uc002hsi.1	+	3	817	c.595G>C	c.(595-597)GAC>CAC	p.D199H		NM_002686	NP_002677	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	199					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			ovary(1)	1	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCGGGCCCTGGACCACATCAC	0.682		NA											6	40					0	0	0	0
GRB7	2886	broad.mit.edu	37	17	37900456	37900456	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:37900456C>A	uc002hsr.2	+	7	1047	c.797C>A	c.(796-798)TCT>TAT	p.S266Y	GRB7_uc002hss.2_Missense_Mutation_p.S266Y|GRB7_uc010cwc.2_Missense_Mutation_p.S266Y|GRB7_uc002hst.2_Missense_Mutation_p.S266Y	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	266	PH.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AAGGGCACCTCTAAGGTAAGG	0.572		NA											17	186					5.04e-11	5.37e-11	1	0
RAPGEFL1	51195	broad.mit.edu	37	17	38348898	38348898	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:38348898C>A	uc010cwu.1	+	12	1569	c.1079C>A	c.(1078-1080)TCC>TAC	p.S360Y	RAPGEFL1_uc010wfd.1_Missense_Mutation_p.S296Y	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	566	Ras-GEF.				G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGTGATCTCCAAAATGAAG	0.527		NA											38	233					4.67e-22	5.02e-22	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:39274291T>C	uc002hvz.2	-	1	316	c.277A>G	c.(277-279)ATG>GTG	p.M93V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	14.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.388		NA											6	37					0	0	0	0
CCDC56	28958	broad.mit.edu	37	17	40948652	40948652	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:40948652C>T	uc010wgz.1	-	2	350	c.73G>A	c.(73-75)GAA>AAA	p.E25K	WNK4_uc002ibj.2_Intron|WNK4_uc010wgx.1_Intron|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank			Q9Y2R0	CCD56_HUMAN	SubName: Full=cDNA FLJ50764;	Error:Variant_position_missing_in_Q9Y2R0_after_alignment						integral to membrane					0		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0741)		GCTGCAGCTTCGCCTTCCTCC	0.587		NA											16	69					0	0	0	0
TMEM101	84336	broad.mit.edu	37	17	42092252	42092252	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:42092252G>A	uc002ieu.2	-	1	94	c.69C>T	c.(67-69)CTC>CTT	p.L23L	TMEM101_uc010wis.1_Intron	NM_032376	NP_115752	Q96IK0	TM101_HUMAN	transmembrane protein 101	23	Helical; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		Breast(137;0.0264)|Prostate(33;0.0861)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GGCAGCGTGTGAGCAGCACCG	0.627		NA											22	63					0	0	0	0
G6PC3	92579	broad.mit.edu	37	17	42153206	42153206	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:42153206G>A	uc002iex.2	+	6	1052	c.836G>A	c.(835-837)GGA>GAA	p.G279E	G6PC3_uc002iey.2_Missense_Mutation_p.G154E|G6PC3_uc010czo.2_Missense_Mutation_p.G135E|G6PC3_uc002iez.2_Missense_Mutation_p.G154E|G6PC3_uc002ifb.2_Missense_Mutation_p.G154E|G6PC3_uc002ifc.2_Missense_Mutation_p.G88E	NM_138387	NP_612396	Q9BUM1	G6PC3_HUMAN	glucose-6-phosphatase catalytic subunit 3	279	Cytoplasmic (Potential).				gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			skin(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCACAGCTGGGAAATGGCCAG	0.652		NA											12	52					0	0	0	0
NMT1	4836	broad.mit.edu	37	17	43171126	43171126	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:43171126C>G	uc002ihz.2	+	4	477	c.459C>G	c.(457-459)CCC>CCG	p.P153P	NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	153					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				ACACCCTGCCCCAGGGCTTCA	0.597		NA											9	54					0	0	0	0
COPZ2	51226	broad.mit.edu	37	17	46111232	46111232	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:46111232C>T	uc002imy.2	-	7	278	c.265G>A	c.(265-267)GAG>AAG	p.E89K		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	89					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CACTTACTCTCAGTCCGGCTG	0.483		NA											3	20					0	0	0	0
HOXB8	3218	broad.mit.edu	37	17	46690757	46690757	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:46690757G>C	uc002inw.2	-	2	774	c.539C>G	c.(538-540)TCG>TGG	p.S180W	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	180	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGGGCGTGCGATACCTCGAT	0.532		NA											11	93					0	0	0	0
MYST2	11143	broad.mit.edu	37	17	47886529	47886529	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:47886529C>G	uc002ipm.2	+	6	838	c.712C>G	c.(712-714)CAC>GAC	p.H238D	MYST2_uc002ipl.1_Intron|MYST2_uc010wma.1_Missense_Mutation_p.H99D|MYST2_uc010wmb.1_Intron|MYST2_uc010wmc.1_Intron|MYST2_uc010wmd.1_Missense_Mutation_p.H82D|MYST2_uc010wme.1_Intron	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	238					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GATGCTGTCTCACAGGCAAGA	0.478		NA											10	49					0	0	0	0
USP32	84669	broad.mit.edu	37	17	58282903	58282903	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:58282903C>T	uc002iyo.1	-	26	3440	c.3154G>A	c.(3154-3156)GAG>AAG	p.E1052K	USP32_uc002iyn.1_Missense_Mutation_p.E722K	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1052					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AAGTTCTTCTCAGTTCCACAT	0.443		NA											11	78					0	0	0	0
TLK2	11011	broad.mit.edu	37	17	60598187	60598187	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:60598187G>C	uc010ddp.2	+	3	403	c.135G>C	c.(133-135)TTG>TTC	p.L45F	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Missense_Mutation_p.L45F|TLK2_uc002jaa.3_Missense_Mutation_p.L45F|TLK2_uc010wpd.1_Missense_Mutation_p.L45F	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	45					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TCGGATCCTTGAGTGATAAAG	0.299		NA											12	79					0	0	0	0
LIMD2	80774	broad.mit.edu	37	17	61776232	61776232	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:61776232C>T	uc002jbj.3	-	4	329	c.151G>A	c.(151-153)GAG>AAG	p.E51K	LIMD2_uc002jbk.3_Missense_Mutation_p.G52E|LIMD2_uc002jbl.3_Missense_Mutation_p.E51K	NM_030576	NP_085053	Q9BT23	LIMD2_HUMAN	LIM domain containing 2	51	LIM zinc-binding.						zinc ion binding				0						ACCAGCCGCTCCATGGGGTAC	0.562		NA											12	74					0	0	0	0
PRKCA	5578	broad.mit.edu	37	17	64683318	64683318	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:64683318G>A	uc002jfp.1	+	6	663	c.619G>A	c.(619-621)GAA>AAA	p.E207K	PRKCA_uc002jfo.1_Missense_Mutation_p.E78K	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	207	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	TCCCAAGAATGAAAGCAAGCA	0.408		NA											27	127					0	0	0	0
HELZ	9931	broad.mit.edu	37	17	65147302	65147302	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:65147302G>A	uc010wqk.1	-	18	2406	c.2219C>T	c.(2218-2220)CCA>CTA	p.P740L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.P739L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ATGCACAACTGGGTGGACAGT	0.373		NA											21	87					0	0	0	0
KPNA2	3838	broad.mit.edu	37	17	66039309	66039309	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:66039309C>T	uc002jgk.2	+	7	892	c.760C>T	c.(760-762)CCT>TCT	p.P254S	KPNA2_uc002jgl.2_Missense_Mutation_p.P254S	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	254	ARM 5.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCAGATTCTTCCTACCTTAGT	0.468		NA											49	291					0	0	0	0
KPNA2	3838	broad.mit.edu	37	17	66042035	66042035	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:66042035G>A	uc002jgk.2	+	10	1627	c.1495G>A	c.(1495-1497)GAG>AAG	p.E499K	KPNA2_uc002jgl.2_Missense_Mutation_p.E499K	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	499	Poly-Glu.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTTCTCTGTAGAGGTGAGTAA	0.328		NA											23	102					0	0	0	0
GGA3	23163	broad.mit.edu	37	17	73237033	73237033	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:73237033G>A	uc002jni.1	-	11	1061	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L	GGA3_uc002jnj.1_Missense_Mutation_p.S318L|GGA3_uc010wrw.1_Missense_Mutation_p.S229L|GGA3_uc002jnk.1_Missense_Mutation_p.S279L|GGA3_uc010wrx.1_Missense_Mutation_p.S229L|GGA3_uc010wry.1_Missense_Mutation_p.S279L	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	351	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TGGGATGCCTGAGGAGGGTGG	0.647		NA									OREG0024730	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	56					0	0	0	0
TRIM65	201292	broad.mit.edu	37	17	73887415	73887415	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:73887415C>T	uc002jpx.2	-	6	1035	c.999G>A	c.(997-999)CTG>CTA	p.L333L		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	333	B30.2/SPRY.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GATCAAAGGTCAGATTGCGAT	0.498		NA											8	19					0	0	0	0
TNRC6C	57690	broad.mit.edu	37	17	76045388	76045388	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:76045388G>A	uc002jud.2	+	4	845	c.245G>A	c.(244-246)AGA>AAA	p.R82K	TNRC6C_uc002juf.2_Missense_Mutation_p.R82K|TNRC6C_uc002jue.2_Missense_Mutation_p.R82K	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	82	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GGAGATGGGAGAAGTCAGAAT	0.522		NA											15	79					0	0	0	0
LGALS3BP	3959	broad.mit.edu	37	17	76967746	76967746	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:76967746G>A	uc002jwh.2	-	6	1849	c.1670C>T	c.(1669-1671)TCC>TTC	p.S557F	LGALS3BP_uc002jwi.2_Missense_Mutation_p.S363F|LGALS3BP_uc010dhr.2_Missense_Mutation_p.S363F	NM_005567	NP_005558	Q08380	LG3BP_HUMAN	galectin 3 binding protein	557					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			central_nervous_system(3)|ovary(1)	4			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			GGGGAAGGAGGAGGTGCTCTT	0.632		NA									OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	55					0	0	0	0
CARD14	79092	broad.mit.edu	37	17	78156549	78156549	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:78156549C>T	uc002jxw.1	+	3	504	c.309C>T	c.(307-309)GTC>GTT	p.V103V	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Silent_p.V103V|CARD14_uc010wud.1_5'Flank	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	103	CARD.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			ACACCCTGGTCACCGGGCTGC	0.557		NA											8	35					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78320513	78320513	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:78320513C>G	uc002jyh.1	+	4	2820	c.2597C>G	c.(2596-2598)TCA>TGA	p.S866*		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCTGCCTACTCAGATCTCTTC	0.642		NA											4	11					0	0	0	0
FN3KRP	79672	broad.mit.edu	37	17	80674690	80674690	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80674690C>A	uc002kfu.2	+	1	109	c.59C>A	c.(58-60)TCG>TAG	p.S20*	FN3KRP_uc010wvr.1_5'UTR	NM_024619	NP_078895	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	20							kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			ACGGGCCACTCGGGGGGCGGG	0.706		NA											5	19					0.00116845	0.00119389	1	0
ZNF750	79755	broad.mit.edu	37	17	80788498	80788498	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80788498C>T	uc002kga.2	-	3	2003	c.1692G>A	c.(1690-1692)CCG>CCA	p.P564P	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	564						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGCAGGCCTCGGAGCCTGGG	0.627		NA											14	57					0	0	0	0
ZNF750	79755	broad.mit.edu	37	17	80789280	80789280	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80789280C>T	uc002kga.2	-	2	1362	c.1051G>A	c.(1051-1053)GAA>AAA	p.E351K	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	351						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GTGGCTTCTTCAAGCAGGTGA	0.532		NA											32	129					0	0	0	0
ZNF750	79755	broad.mit.edu	37	17	80790150	80790150	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr17:80790150G>A	uc002kga.2	-	2	492	c.181C>T	c.(181-183)CGA>TGA	p.R61*	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	61						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TTGGGAACTCGATCCTGCTCT	0.448		NA											15	63					0	0	0	0
CLUL1	27098	broad.mit.edu	37	18	627346	627346	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:627346G>A	uc002kkp.2	+	5	818	c.673G>A	c.(673-675)GAG>AAG	p.E225K	CLUL1_uc010wys.1_Missense_Mutation_p.E277K|CLUL1_uc002kkq.2_Missense_Mutation_p.E225K	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	225					cell death	extracellular region				ovary(2)	2						AGACCTAACTGAGCCTTACTT	0.388		NA											16	115					0	0	0	0
KIAA0802	23255	broad.mit.edu	37	18	8796233	8796233	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:8796233G>C	uc002knr.2	+	9	2156	c.2014G>C	c.(2014-2016)GAG>CAG	p.E672Q	KIAA0802_uc002knq.2_Missense_Mutation_p.E631Q|KIAA0802_uc002kns.2_Missense_Mutation_p.E2Q	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	982											0						ATTCAAGATGGAGGAGGAGCA	0.498		NA											10	87					0	0	0	0
KIAA0802	23255	broad.mit.edu	37	18	8796331	8796331	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:8796331G>C	uc002knr.2	+	9	2254	c.2112G>C	c.(2110-2112)AAG>AAC	p.K704N	KIAA0802_uc002knq.2_Missense_Mutation_p.K663N|KIAA0802_uc002kns.2_Missense_Mutation_p.K34N	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1014											0						GTGATGAGAAGAATCTGATGC	0.522		NA											12	80					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31324832	31324832	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:31324832G>A	uc010dmg.1	+	12	5075	c.5020G>A	c.(5020-5022)GAA>AAA	p.E1674K	ASXL3_uc002kxq.2_Missense_Mutation_p.E1381K	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1674					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TGAACTTCACGAAGCAGACAA	0.478		NA											12	63					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31325319	31325319	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:31325319G>A	uc010dmg.1	+	12	5562	c.5507G>A	c.(5506-5508)GGA>GAA	p.G1836E	ASXL3_uc002kxq.2_Missense_Mutation_p.G1543E	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1836					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGGACTGTAGGAGAACACACT	0.483		NA											44	210					0	0	0	0
SLC39A6	25800	broad.mit.edu	37	18	33689584	33689584	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:33689584T>A	uc010dmy.2	-	10	2530	c.2240A>T	c.(2239-2241)CAT>CTT	p.H747L		NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	747	Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						CACGATTTTATGTTCAAATAT	0.353		NA											21	118					0	0	0	0
CCBE1	147372	broad.mit.edu	37	18	57363888	57363888	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr18:57363888G>C	uc002lib.2	-	2	255	c.185C>G	c.(184-186)TCT>TGT	p.S62C		NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	62					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				CTCGCCTGAAGACTTCAGACA	0.572		NA									OREG0025022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	117					0	0	0	0
ZNF554	115196	broad.mit.edu	37	19	2834250	2834250	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:2834250G>C	uc002lwm.2	+	5	1215	c.1017G>C	c.(1015-1017)TTG>TTC	p.L339F	ZNF554_uc002lwl.2_Missense_Mutation_p.L288F	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	339	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCATTCTTTGAGCGAACATC	0.537		NA											9	66					0	0	0	0
ZNF554	115196	broad.mit.edu	37	19	2834551	2834551	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:2834551G>A	uc002lwm.2	+	5	1516	c.1318G>A	c.(1318-1320)GAA>AAA	p.E440K	ZNF554_uc002lwl.2_Missense_Mutation_p.E389K	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	440	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAATGCAGTGAATGTGGAAA	0.522		NA											8	40					0	0	0	0
UHRF1	29128	broad.mit.edu	37	19	4929378	4929378	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:4929378G>C	uc002mbo.2	+	3	466	c.298G>C	c.(298-300)GGC>CGC	p.G100R	UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.G113R	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	100					cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		CTGCTGCCTGGGCCAGAGTGA	0.657		NA											6	26					0	0	0	0
TRIP10	9322	broad.mit.edu	37	19	6741022	6741022	+	Missense_Mutation	SNP	A	A	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:6741022A>T	uc002mfs.2	+	2	92	c.26A>T	c.(25-27)GAT>GTT	p.D9V	TRIP10_uc010dux.1_Missense_Mutation_p.D9V|TRIP10_uc002mfr.2_Missense_Mutation_p.D9V|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_5'UTR	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	9	FCH.|Required for podosome formation and interaction with AKAP9 and microtubules.|Induction of membrane tubulation.|Required for translocation to the plasma membrane in response to insulin (By similarity).				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						CCATGTCAGGATCAGTTCGAG	0.617		NA											7	44					0	0	0	0
RDH8	50700	broad.mit.edu	37	19	10132365	10132365	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10132365C>G	uc002mmr.2	+	6	1125	c.876C>G	c.(874-876)CTC>CTG	p.L292L		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	292					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	CACGCCTCCTCAACCTTGGCC	0.612		NA											6	37					0	0	0	0
ANGPTL6	83854	broad.mit.edu	37	19	10204253	10204253	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10204253C>T	uc002mmx.1	-	5	1112	c.994G>A	c.(994-996)GAA>AAA	p.E332K	ANGPTL6_uc002mmy.1_Missense_Mutation_p.E332K	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	332	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			TACACGGGTTCAAGGCCCAGC	0.642		NA											7	20					0	0	0	0
ANGPTL6	83854	broad.mit.edu	37	19	10204273	10204273	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10204273C>T	uc002mmx.1	-	5	1092	c.974G>A	c.(973-975)GGA>GAA	p.G325E	ANGPTL6_uc002mmy.1_Missense_Mutation_p.G325E	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	325	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			CCAGTATTCTCCGTCTGGCCG	0.647		NA											6	20					0	0	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10220614	10220614	+	Missense_Mutation	SNP	G	G	A	rs149200523	byFrequency	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:10220614G>A	uc002mna.2	+	7	616	c.616G>A	c.(616-618)GCG>ACG	p.A206T	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.A206T|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.A206T|PPAN_uc002mnb.1_Missense_Mutation_p.A153T	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	206	Brix.				RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TCCTGTGGGCGCGAGTCGCGG	0.627		NA											8	107					0	0	0	0
ZNF627	199692	broad.mit.edu	37	19	11725686	11725686	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:11725686C>T	uc002msk.2	+	3	383	c.175C>T	c.(175-177)CCC>TCC	p.P59S	ZNF627_uc010dyf.2_5'UTR	NM_145295	NP_660338	Q7L945	ZN627_HUMAN	zinc finger protein 627	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATTCAAAATTCCCAGGAGAAA	0.279		NA											3	21					0	0	0	0
ZNF563	147837	broad.mit.edu	37	19	12429881	12429881	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:12429881G>A	uc002mtp.2	-	4	1196	c.958C>T	c.(958-960)CAT>TAT	p.H320Y		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	320	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCCAAGATGATGAAATGTT	0.438		NA											23	134					0	0	0	0
C19orf44	84167	broad.mit.edu	37	19	16611792	16611792	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:16611792C>G	uc002neh.1	+	2	262	c.189C>G	c.(187-189)CTC>CTG	p.L63L	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Silent_p.L63L|C19orf44_uc002neg.2_Silent_p.L63L|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	63											0						AACACTTACTCCTGAAAGAGA	0.478		NA											26	192					0	0	0	0
NWD1	284434	broad.mit.edu	37	19	16875993	16875993	+	Silent	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:16875993C>A	uc002neu.3	+	10	2822	c.2400C>A	c.(2398-2400)CTC>CTA	p.L800L	NWD1_uc002net.3_Silent_p.L665L|NWD1_uc002nev.3_Silent_p.L594L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	800							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CTGTGGAGCTCCGAGGCATGG	0.587		NA											5	25					0.000602214	0.000618211	1	0
GLT25D1	79709	broad.mit.edu	37	19	17691701	17691701	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:17691701G>A	uc002nhc.1	+	11	1600	c.1588G>A	c.(1588-1590)GAC>AAC	p.D530N	GLT25D1_uc010eax.1_Missense_Mutation_p.D258N|GLT25D1_uc010eay.1_Missense_Mutation_p.D59N	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	530					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						CGTCATGTTCGACAAACACCC	0.632		NA											6	35					0	0	0	0
FCHO1	23149	broad.mit.edu	37	19	17875220	17875220	+	Silent	SNP	G	G	A	rs148025294		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:17875220G>A	uc010ebb.2	+	5	345	c.156G>A	c.(154-156)GCG>GCA	p.A52A	FCHO1_uc002nhg.3_Silent_p.A52A|FCHO1_uc002nhh.2_Silent_p.A52A|FCHO1_uc010xpw.1_Silent_p.A2A|FCHO1_uc010ebc.1_Silent_p.A59A	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	52	FCH.									breast(1)	1						AGGCGATGGCGAAACTCTCCA	0.512		NA											9	38					0	0	0	0
GDF15	9518	broad.mit.edu	37	19	18497038	18497038	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:18497038G>C	uc002niv.2	+	1	71	c.39G>C	c.(37-39)CAG>CAC	p.Q13H	hsa-mir-3189|MI0014233_5'Flank	NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	13					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						ATGGCTCTCAGATGCTCCTGG	0.647		NA											5	39					0	0	0	0
ZNF682	91120	broad.mit.edu	37	19	20117110	20117110	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:20117110C>T	uc002noq.2	-	4	1324	c.1201G>A	c.(1201-1203)GAA>AAA	p.E401K	ZNF682_uc002noo.2_Missense_Mutation_p.E369K|ZNF682_uc002nop.2_Missense_Mutation_p.E369K|ZNF682_uc010eck.2_Missense_Mutation_p.E325K	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	401	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TTGCCACATTCTTCACATTTG	0.378		NA											16	77					0	0	0	0
ZNF536	9745	broad.mit.edu	37	19	31038871	31038871	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:31038871C>T	uc002nsu.1	+	4	2483	c.2345C>T	c.(2344-2346)CCG>CTG	p.P782L	ZNF536_uc010edd.1_Missense_Mutation_p.P782L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	782	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TACAAGTGTCCGCACTGTGAC	0.502		NA											13	70					0	0	0	0
HPN	3249	broad.mit.edu	37	19	35551551	35551551	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:35551551G>T	uc002nxq.1	+	10	886	c.641G>T	c.(640-642)CGA>CTA	p.R214L	HPN_uc002nxr.1_Missense_Mutation_p.R214L|HPN_uc002nxs.1_Missense_Mutation_p.R56L|HPN_uc010xsh.1_Missense_Mutation_p.R183L|HPN_uc002nxt.1_Missense_Mutation_p.R98L|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	214	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GTCCTGTCCCGATGGCGAGTG	0.682		NA											10	39					3.07e-06	3.22e-06	1	0
CD22	933	broad.mit.edu	37	19	35828818	35828818	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:35828818G>A	uc010edt.2	+	5	956	c.879G>A	c.(877-879)ACG>ACA	p.T293T	CD22_uc010xst.1_Silent_p.T121T|CD22_uc010edu.2_Silent_p.T293T|CD22_uc010edv.2_Silent_p.T293T|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	293	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion		protein binding|sugar binding	p.T293T(1)		ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	ATACATTCACGCTAAACCTGC	0.567		NA											4	43					0	0	0	0
GAPDHS	26330	broad.mit.edu	37	19	36033280	36033280	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:36033280C>G	uc002oaf.1	+	5	625	c.509C>G	c.(508-510)ACA>AGA	p.T170R	uc010eec.1_Intron|uc002oag.2_Intron	NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	170					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	GTGGAGTCCACAGGCGTGTAC	0.637		NA											8	38					0	0	0	0
ZNF570	148268	broad.mit.edu	37	19	37975067	37975067	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:37975067G>C	uc002ogk.1	+	5	1072	c.543G>C	c.(541-543)AAG>AAC	p.K181N	ZNF570_uc010efl.1_Missense_Mutation_p.K237N|ZNF570_uc010xtr.1_5'UTR	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTACACAAAAGATAATCCCCA	0.358		NA											42	183					0	0	0	0
SARS2	54938	broad.mit.edu	37	19	39437135	39437135	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:39437135C>G	uc010xuq.1	-	3	247	c.39G>C	c.(37-39)CAG>CAC	p.Q13H	FBXO17_uc002okg.1_Missense_Mutation_p.Q178H|FBXO17_uc002okf.1_Missense_Mutation_p.Q187H	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	Error:Variant_position_missing_in_Q9NP81_after_alignment					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			AGATCTCAATCTGGGCGCTGT	0.637		NA											12	49					0	0	0	0
CCDC97	90324	broad.mit.edu	37	19	41828509	41828509	+	Silent	SNP	C	C	T	rs143105404		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:41828509C>T	uc002oqg.2	+	5	1043	c.921C>T	c.(919-921)GAC>GAT	p.D307D	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	307											0						GCACAGTAGACGACAACCCCG	0.612		NA											9	88					0	0	0	0
LIPE	3991	broad.mit.edu	37	19	42907160	42907160	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:42907160C>T	uc002otr.2	-	9	2843	c.2566G>A	c.(2566-2568)GAA>AAA	p.E856K	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	856					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				AGTGCTGCTTCAGACACACTG	0.617		NA											6	52					0	0	0	0
FBXO46	23403	broad.mit.edu	37	19	46215859	46215859	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:46215859G>A	uc002pcy.2	-	2	1020	c.895C>T	c.(895-897)CGA>TGA	p.R299*	FBXO46_uc002pcz.2_Nonsense_Mutation_p.R299*	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	299							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		TCCTTGGCTCGGGCCCCAGGA	0.682		NA											4	16					0	0	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973455	46973455	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:46973455C>T	uc002peq.3	-	2	1144	c.838G>A	c.(838-840)GAA>AAA	p.E280K	PNMAL1_uc002per.3_Missense_Mutation_p.E280K	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	280											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GCCATGCTTTCAGCATCACCC	0.517		NA											27	151					0	0	0	0
LMTK3	114783	broad.mit.edu	37	19	49004553	49004553	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:49004553C>T	uc002pjk.2	-	10	1075	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		ATGTTGCTCTCGCGGCTCTGG	0.662		NA											13	66					0	0	0	0
PPFIA3	8541	broad.mit.edu	37	19	49652886	49652886	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:49652886C>G	uc002pmr.2	+	28	3769	c.3437C>G	c.(3436-3438)TCA>TGA	p.S1146*	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Nonsense_Mutation_p.S1005*|PPFIA3_uc002pmt.2_Nonsense_Mutation_p.S285*|PPFIA3_uc002pmu.1_Nonsense_Mutation_p.S195*	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	1146						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ACTCCCGACTCAGCTGAGATG	0.647		NA											3	40					0	0	0	0
MYH14	79784	broad.mit.edu	37	19	50780093	50780093	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:50780093G>A	uc002prr.1	+	27	3684	c.3637G>A	c.(3637-3639)GAG>AAG	p.E1213K	MYH14_uc010enu.1_Missense_Mutation_p.E1254K|MYH14_uc002prq.1_Missense_Mutation_p.E1221K	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1213	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGCAGTGCAGGAGCTGAGGCA	0.532		NA											14	51					0	0	0	0
ZNF808	388558	broad.mit.edu	37	19	53058569	53058569	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:53058569C>T	uc010epq.1	+	5	2577	c.2400C>T	c.(2398-2400)TTC>TTT	p.F800F	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	800	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		ACAAGGCTTTCGTGCGTAATT	0.408		NA											24	190					0	0	0	0
ZNF816A	125893	broad.mit.edu	37	19	53454322	53454322	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:53454322T>C	uc002qal.1	-	5	1007	c.706A>G	c.(706-708)AAA>GAA	p.K236E	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.K220E	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	236	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TTAAAGGCTTTGCCACACTCA	0.348		NA											14	74					0	0	0	0
SUV420H2	84787	broad.mit.edu	37	19	55857665	55857665	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:55857665G>A	uc002qkj.3	+	7	903	c.655G>A	c.(655-657)GAG>AAG	p.E219K	SUV420H2_uc002qkl.2_Missense_Mutation_p.E104K	NM_032701	NP_116090	Q86Y97	SV422_HUMAN	suppressor of variegation 4-20 homolog 2	219	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding				0	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CTTCTACGGCGAGGGCTTCTT	0.622		NA											8	65					0	0	0	0
USP29	57663	broad.mit.edu	37	19	57641988	57641988	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:57641988G>A	uc002qny.2	+	4	2301	c.1945G>A	c.(1945-1947)GAC>AAC	p.D649N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	649					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCAGTGGCTGACTCACTGAT	0.498		NA											6	51					0	0	0	0
MYT1L	23040	broad.mit.edu	37	2	1914020	1914020	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:1914020G>A	uc002qxe.2	-	13	2636	c.1809C>T	c.(1807-1809)CGC>CGT	p.R603R	MYT1L_uc002qxd.2_Silent_p.R601R|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	603					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACCTGAGCACGCGGTCCGAGG	0.637		NA											5	37					0	0	0	0
GRHL1	29841	broad.mit.edu	37	2	10136520	10136520	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:10136520G>C	uc002raa.2	+	14	1839	c.1668G>C	c.(1666-1668)TTG>TTC	p.L556F	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.L367F|GRHL1_uc010yjb.1_Missense_Mutation_p.L405F	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	556					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TGAAGGGCTTGATGGAAGCTG	0.413		NA											20	82					0	0	0	0
ROCK2	9475	broad.mit.edu	37	2	11361348	11361348	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:11361348C>G	uc002rbd.1	-	9	1684	c.1235G>C	c.(1234-1236)GGA>GCA	p.G412A		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	412	Interaction with NPM1.|AGC-kinase C-terminal.|Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GTAGGTAAATCCGATGAAAGG	0.323		NA											24	123					0	0	0	0
E2F6	1876	broad.mit.edu	37	2	11605933	11605933	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:11605933G>A	uc002rbh.2	-	1	365	c.73C>T	c.(73-75)CGG>TGG	p.R25W	E2F6_uc002rbe.2_5'UTR|E2F6_uc002rbf.2_5'UTR|E2F6_uc002rbg.2_5'UTR|E2F6_uc002rbi.2_5'UTR|E2F6_uc010yjl.1_RNA|E2F6_uc002rbj.1_RNA	NM_198256	NP_937987	O75461	E2F6_HUMAN	E2F transcription factor 6	25					negative regulation of transcription from RNA polymerase II promoter	MLL1 complex|transcription factor complex	DNA binding|transcription corepressor activity			skin(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.114)|OV - Ovarian serous cystadenocarcinoma(76;0.168)		TCTCGGCACCGACGGCGAACC	0.716		NA											5	7					0	0	0	0
NBAS	51594	broad.mit.edu	37	2	15417101	15417101	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:15417101C>T	uc002rcc.1	-	43	5289	c.5263G>A	c.(5263-5265)GAT>AAT	p.D1755N	NBAS_uc010exl.1_Missense_Mutation_p.D827N|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1755										ovary(2)|liver(1)|skin(1)	4						CTTTCGTGATCAAAGCCACCA	0.443		NA											6	51					0	0	0	0
IFT172	26160	broad.mit.edu	37	2	27685974	27685974	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:27685974G>T	uc002rku.2	-	19	2063	c.2012C>A	c.(2011-2013)TCC>TAC	p.S671Y		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	671					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					ATATTCCCGGGATACTTGATC	0.438		NA											8	58					5.49e-09	5.83e-09	1	0
LCLAT1	253558	broad.mit.edu	37	2	30756062	30756062	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:30756062C>G	uc002rnj.2	+	4	569	c.360C>G	c.(358-360)ATC>ATG	p.I120M	LCLAT1_uc010ymp.1_Translation_Start_Site|LCLAT1_uc002rnk.1_Missense_Mutation_p.I120M|LCLAT1_uc002rnl.2_Missense_Mutation_p.I82M|LCLAT1_uc010ymq.1_Missense_Mutation_p.I82M	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	120					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						GTGTCATTATCATGAACCATC	0.403		NA											13	133					0	0	0	0
BIRC6	57448	broad.mit.edu	37	2	32626362	32626362	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:32626362C>G	uc010ezu.2	+	7	1300	c.1166C>G	c.(1165-1167)TCT>TGT	p.S389C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	389					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GACAGAATATCTTGCTTTGGG	0.453		NA											41	230					0	0	0	0
CDKL4	344387	broad.mit.edu	37	2	39411779	39411779	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:39411779C>G	uc002rrm.2	-	7	745	c.745G>C	c.(745-747)GAG>CAG	p.E249Q	CDKL4_uc010fal.1_Missense_Mutation_p.E249Q	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	249	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				AACTTTTCCTCAAGAGTTTCC	0.239		NA											3	40					0	0	0	0
LRPPRC	10128	broad.mit.edu	37	2	44116941	44116941	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:44116941G>C	uc002rtr.2	-	37	4118	c.4060C>G	c.(4060-4062)CTG>GTG	p.L1354V		NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1354	RNA-binding.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTTAGAAACAGATCATCCAAT	0.358		NA											11	74					0	0	0	0
C2orf34	79823	broad.mit.edu	37	2	44970813	44970813	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:44970813G>A	uc002rum.2	+	8	780	c.676G>A	c.(676-678)GAC>AAC	p.D226N		NM_024766	NP_079042	Q7Z624	CMKMT_HUMAN	hypothetical protein LOC79823	226						cytoplasm	calmodulin-lysine N-methyltransferase activity				0		all_hematologic(82;0.0892)|Acute lymphoblastic leukemia(82;0.17)				AGGACATTTTGACATTGTTAT	0.343		NA											7	26					0	0	0	0
SOCS5	9655	broad.mit.edu	37	2	46986106	46986106	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:46986106G>A	uc002rvf.2	+	2	601	c.437G>A	c.(436-438)CGA>CAA	p.R146Q	SOCS5_uc010yoe.1_Missense_Mutation_p.R115Q|SOCS5_uc002rvg.2_Missense_Mutation_p.R146Q	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	146					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GGTAGAACTCGAAGTGGACTT	0.468		NA											16	67					0	0	0	0
SPTBN1	6711	broad.mit.edu	37	2	54876298	54876298	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:54876298G>A	uc002rxu.2	+	25	5422	c.5173G>A	c.(5173-5175)GAA>AAA	p.E1725K	SPTBN1_uc002rxx.2_Missense_Mutation_p.E1712K	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1725	Interaction with ANK2.|Spectrin 14.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGGGTCCCATGAACTGGGACA	0.552		NA											12	64					0	0	0	0
PNO1	56902	broad.mit.edu	37	2	68389791	68389791	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:68389791G>A	uc002seh.2	+	5	678	c.616G>A	c.(616-618)GAT>AAT	p.D206N		NM_020143	NP_064528	Q9NRX1	PNO1_HUMAN	partner of NOB1	206	KH.					nucleolus	RNA binding				0						AGTTTTGGCTGATGTGTAAGT	0.353		NA											13	65					0	0	0	0
HK2	3099	broad.mit.edu	37	2	75061710	75061710	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:75061710G>A	uc002snd.2	+	1	1929	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	1	Hydrophobic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GCGGCAGGATGATTGCCTCGC	0.677		NA											6	42					0	0	0	0
VAMP5	10791	broad.mit.edu	37	2	85818887	85818887	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:85818887G>A	uc002spu.1	+	2	126	c.43G>A	c.(43-45)GAG>AAG	p.E15K		NM_006634	NP_006625	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	15	v-SNARE coiled-coil homology.|Cytoplasmic (Potential).				cell differentiation|vesicle-mediated transport	endomembrane system					0						GCAGGCGAACGAGGTGACGGA	0.602		NA											21	80					0	0	0	0
PROM2	150696	broad.mit.edu	37	2	95953210	95953210	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:95953210G>T	uc002suh.1	+	20	2375	c.2242G>T	c.(2242-2244)GAG>TAG	p.E748*	PROM2_uc002sui.2_Nonsense_Mutation_p.E748*|PROM2_uc002suj.2_Nonsense_Mutation_p.E402*|PROM2_uc002suk.2_Nonsense_Mutation_p.E748*|PROM2_uc002sul.2_Nonsense_Mutation_p.E274*|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	748	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GGTGAGAGAGGAGGTGAGTGG	0.642		NA											5	40					0.000602214	0.000618211	1	0
AFF3	3899	broad.mit.edu	37	2	100203693	100203693	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:100203693C>G	uc002tag.2	-	15	2750	c.2514G>C	c.(2512-2514)GAG>GAC	p.E838D	AFF3_uc002taf.2_Missense_Mutation_p.E863D|AFF3_uc010fiq.1_Missense_Mutation_p.E838D|AFF3_uc010yvr.1_Missense_Mutation_p.E991D|AFF3_uc002tah.1_Missense_Mutation_p.E863D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	838					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						AGCTGTCTTTCTCTCCCTGGG	0.453		NA											32	148					0	0	0	0
NMS	129521	broad.mit.edu	37	2	101096984	101096984	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:101096984C>T	uc002tan.1	+	7	370	c.363C>T	c.(361-363)TTC>TTT	p.F121F		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	121					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						CAGTGGACTTCACCAAGAAGG	0.562		NA											8	52					0	0	0	0
C1QL2	165257	broad.mit.edu	37	2	119915802	119915802	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:119915802G>T	uc002tlo.2	-	1	670	c.44C>A	c.(43-45)GCG>GAG	p.A15E		NM_182528	NP_872334	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	15						collagen				pancreas(1)	1						TCGGGGCGCCGCCTGCAGCAG	0.741		NA								HNSCC(49;0.14)			4	5					1.24e-05	1.29e-05	1	0
CNTNAP5	129684	broad.mit.edu	37	2	124783248	124783248	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:124783248G>A	uc002tno.2	+	1	385	c.21G>A	c.(19-21)CTG>CTA	p.L7L	CNTNAP5_uc010flu.2_Silent_p.L7L	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	7					cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TACCACGGCTGACCAGCGTTT	0.547		NA											8	71					0	0	0	0
DARS	1615	broad.mit.edu	37	2	136740989	136740989	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:136740989C>G	uc002tux.1	-	2	286	c.102G>C	c.(100-102)ATG>ATC	p.M34I	DARS_uc010fnj.1_Intron	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	34					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GTGATTGTATCATTGAAGATA	0.299		NA											2	8					0	0	0	0
NMI	9111	broad.mit.edu	37	2	152132175	152132175	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:152132175C>G	uc002txi.2	-	6	787	c.457G>C	c.(457-459)GAA>CAA	p.E153Q	NMI_uc010zbx.1_3'UTR	NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	153					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		TTAGAAACTTCTACATAAACC	0.343		NA											6	73					0	0	0	0
PKP4	8502	broad.mit.edu	37	2	159530188	159530188	+	Splice_Site	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:159530188G>A	uc002tzv.2	+	18	3185	c.2925_splice	c.e18-1	p.R975_splice	PKP4_uc002tzw.2_Splice_Site_p.R975_splice|PKP4_uc002tzx.2_Splice_Site_p.R632_splice|PKP4_uc002uaa.2_Splice_Site_p.R827_splice|uc002uab.1_Intron|PKP4_uc002uac.2_Splice_Site_p.R156_splice|PKP4_uc002uad.2_Splice_Site|PKP4_uc002uae.1_Splice_Site_p.R62_splice	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a						cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						TCTCTACCTAGATCATCTCTG	0.478		NA								HNSCC(62;0.18)			11	53					0	0	0	0
WDSUB1	151525	broad.mit.edu	37	2	160092614	160092614	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:160092614G>A	uc002uaj.3	-	11	1510	c.1361C>T	c.(1360-1362)TCA>TTA	p.S454L	WDSUB1_uc002uak.3_Missense_Mutation_p.S454L|WDSUB1_uc002ual.3_Missense_Mutation_p.S454L|WDSUB1_uc002uam.3_Missense_Mutation_p.S407L|WDSUB1_uc010foo.2_Missense_Mutation_p.S362L	NM_152528	NP_689741	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain	454	U-box.					ubiquitin ligase complex	ubiquitin-protein ligase activity				0						AAGTACCGCTGAAGGAAGAAC	0.333		NA											10	36					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	166011139	166011139	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:166011139C>T	uc002ucx.2	-	11	1695	c.1203G>A	c.(1201-1203)ATG>ATA	p.M401I	SCN3A_uc002ucy.2_Missense_Mutation_p.M401I|SCN3A_uc002ucz.2_Missense_Mutation_p.M401I|SCN3A_uc002uda.1_Missense_Mutation_p.M270I|SCN3A_uc002udb.1_Missense_Mutation_p.M270I	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	401	Helical; Name=S6 of repeat I; (Potential).			M -> T (in Ref. 4; AAC29514/AAC29515).		voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CAAAAAATATCATGTATGTTT	0.413		NA											17	65					0	0	0	0
SCN7A	6332	broad.mit.edu	37	2	167262119	167262119	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:167262119C>A	uc002udu.1	-	25	5147	c.5020G>T	c.(5020-5022)GAA>TAA	p.E1674*		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1674					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.E1674K(1)		large_intestine(1)	1						GGTGACTTTTCCTTAGCTTTG	0.353		NA											38	189					3.09e-21	3.33e-21	1	0
ABCB11	8647	broad.mit.edu	37	2	169869909	169869909	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:169869909C>G	uc002ueo.1	-	5	388	c.262G>C	c.(262-264)GAT>CAT	p.D88H		NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	88	ABC transmembrane type-1 1.|Extracellular (Potential).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ATAAAAACATCTGTCATTGTG	0.423		NA											34	192					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179497295	179497295	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:179497295C>G	uc010zfg.1	-	184	35958	c.35734G>C	c.(35734-35736)GAA>CAA	p.E11912Q	TTN_uc010zfh.1_Missense_Mutation_p.E5607Q|TTN_uc010zfi.1_Missense_Mutation_p.E5540Q|TTN_uc010zfj.1_Missense_Mutation_p.E5415Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12839							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCAGCTTCAAACATGTAT	0.348		NA											25	104					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179497313	179497313	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:179497313C>T	uc010zfg.1	-	184	35940	c.35716G>A	c.(35716-35718)GAA>AAA	p.E11906K	TTN_uc010zfh.1_Missense_Mutation_p.E5601K|TTN_uc010zfi.1_Missense_Mutation_p.E5534K|TTN_uc010zfj.1_Missense_Mutation_p.E5409K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTTGCTTCATCTTCAAAA	0.373		NA											30	144					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179547472	179547472	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:179547472C>T	uc010zfg.1	-	132	29538	c.29314G>A	c.(29314-29316)GAG>AAG	p.E9772K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6433K|TTN_uc010fre.1_Missense_Mutation_p.E619K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10699							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCGCTCCTCGTATTCTTCA	0.358		NA											30	216					0	0	0	0
DUSP19	142679	broad.mit.edu	37	2	183960237	183960237	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:183960237G>A	uc002upd.2	+	4	880	c.505G>A	c.(505-507)GAA>AAA	p.E169K	DUSP19_uc010frp.2_Missense_Mutation_p.E118K|DUSP19_uc010zfr.1_RNA|DUSP19_uc002upe.2_3'UTR	NM_080876	NP_543152	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19 isoform 1	169	Tyrosine-protein phosphatase.				JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			ovary(4)|pancreas(1)	5						GATGAATTCTGAACAAACCTC	0.388		NA											19	130					0	0	0	0
DUSP19	142679	broad.mit.edu	37	2	183960345	183960345	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:183960345G>A	uc002upd.2	+	4	988	c.613G>A	c.(613-615)GAA>AAA	p.E205K	DUSP19_uc010frp.2_Missense_Mutation_p.E154K|DUSP19_uc010zfr.1_RNA|DUSP19_uc002upe.2_3'UTR	NM_080876	NP_543152	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19 isoform 1	205					JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			ovary(4)|pancreas(1)	5						AGAGGGCAAAGAAAGCAATAA	0.398		NA											10	50					0	0	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800988	185800988	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:185800988G>C	uc002uph.2	+	4	1459	c.865G>C	c.(865-867)GAA>CAA	p.E289Q		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	289						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAGAGACAAAGAAACTGTTCA	0.363		NA											9	52					0	0	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187702178	187702178	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:187702178C>G	uc002upu.1	-	5	638	c.598G>C	c.(598-600)GAG>CAG	p.E200Q		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	200					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GGTGCAAACTCTTTCCTGCAC	0.383		NA											10	85					0	0	0	0
MPP4	58538	broad.mit.edu	37	2	202550741	202550741	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:202550741C>T	uc002uyk.3	-	6	601	c.393G>A	c.(391-393)CAG>CAA	p.Q131Q	MPP4_uc010ftj.2_Silent_p.Q131Q|MPP4_uc010zhq.1_Silent_p.Q131Q|MPP4_uc010zhr.1_Silent_p.Q131Q|MPP4_uc010zhs.1_Intron|MPP4_uc002uyj.3_Intron|MPP4_uc010zht.1_Silent_p.Q104Q|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Silent_p.Q131Q|MPP4_uc002uym.1_Intron|MPP4_uc002uyn.2_Intron	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	131	L27 2.					cytoplasm	protein binding				0						CAAAATCTTTCTGAGCTATCG	0.493		NA											29	137					0	0	0	0
ICOS	29851	broad.mit.edu	37	2	204820605	204820605	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:204820605C>T	uc002vam.2	+	2	372	c.305C>T	c.(304-306)TCT>TTT	p.S102F	ICOS_uc010zip.1_Missense_Mutation_p.S102F|ICOS_uc010fua.2_Missense_Mutation_p.S102F	NM_012092	NP_036224	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator precursor	102	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	extracellular region					0						TTGGACCATTCTCATGCCAAC	0.358		NA											9	69					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212566850	212566850	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:212566850G>C	uc002veg.1	-	12	1429	c.1331C>G	c.(1330-1332)TCT>TGT	p.S444C	ERBB4_uc002veh.1_Missense_Mutation_p.S444C|ERBB4_uc010zji.1_Missense_Mutation_p.S444C|ERBB4_uc010zjj.1_Missense_Mutation_p.S444C|ERBB4_uc010fut.1_Missense_Mutation_p.S444C	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	444	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GAACTGTAGAGAGGTGATGCC	0.458		NA								TSP Lung(8;0.080)			13	83					0	0	0	0
TNS1	7145	broad.mit.edu	37	2	218749773	218749773	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:218749773C>G	uc002vgt.2	-	14	1254	c.856G>C	c.(856-858)GAT>CAT	p.D286H	TNS1_uc002vgr.2_Missense_Mutation_p.D286H|TNS1_uc002vgs.2_Missense_Mutation_p.D286H|TNS1_uc010zjv.1_Missense_Mutation_p.D286H|TNS1_uc010fvj.1_Missense_Mutation_p.D354H|TNS1_uc010fvk.1_Missense_Mutation_p.D411H|TNS1_uc002vgu.3_Missense_Mutation_p.D317H|TNS1_uc010fvi.1_5'UTR	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	286	C2 tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		AAAGCATCATCAAGGTCCTCC	0.577		NA											4	52					0	0	0	0
ATG9A	79065	broad.mit.edu	37	2	220085575	220085575	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:220085575C>T	uc002vke.1	-	15	2594	c.2408G>A	c.(2407-2409)CGG>CAG	p.R803Q	ABCB6_uc002vkc.1_5'Flank|ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Missense_Mutation_p.R803Q	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	803	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGAGGCAGCCGAGAGAAATG	0.577		NA											11	44					0	0	0	0
COL4A4	1286	broad.mit.edu	37	2	227958967	227958967	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:227958967G>C	uc010zlt.1	-	20	1897	c.1243C>G	c.(1243-1245)CTT>GTT	p.L415V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	415	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AGCCCAGGAAGACCAGGAAAT	0.502		NA											5	33					0	0	0	0
COL4A3	1285	broad.mit.edu	37	2	228109061	228109061	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:228109061C>T	uc002vom.1	+	4	422	c.260C>T	c.(259-261)ACG>ATG	p.T87M	COL4A3_uc002von.1_Missense_Mutation_p.T87M|COL4A3_uc002voo.1_Missense_Mutation_p.T87M|COL4A3_uc002vop.1_Missense_Mutation_p.T87M|uc002voq.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	87	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CCAGGACTCACGGGTTCCAAA	0.378		NA											13	73					0	0	0	0
GIGYF2	26058	broad.mit.edu	37	2	233671258	233671258	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:233671258C>G	uc002vti.3	+	17	2034	c.1697C>G	c.(1696-1698)TCT>TGT	p.S566C	GIGYF2_uc010zmj.1_Missense_Mutation_p.S566C|GIGYF2_uc002vtg.2_Missense_Mutation_p.S560C|GIGYF2_uc002vtj.3_Missense_Mutation_p.S587C|GIGYF2_uc002vtk.3_Missense_Mutation_p.S566C|GIGYF2_uc002vth.3_Missense_Mutation_p.S560C|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.S397C	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	566	GYF.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TTTACTATGTCTTTATTGGTG	0.438		NA											33	147					0	0	0	0
NEU2	4759	broad.mit.edu	37	2	233899032	233899032	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:233899032G>A	uc010zmn.1	+	2	408	c.408G>A	c.(406-408)TGG>TGA	p.W136*		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	136	BNR 1.						exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GGAGGACCTGGAGCTCCCCCA	0.637		NA											10	37					0	0	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950502	235950502	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr2:235950502G>A	uc002vvp.2	+	4	1482	c.1089G>A	c.(1087-1089)CCG>CCA	p.P363P	SH3BP4_uc010fym.2_Silent_p.P363P|SH3BP4_uc002vvq.2_Silent_p.P363P	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	363					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TGGACCCCCCGCTGGAGCTCA	0.597		NA											6	45					0	0	0	0
LBP	3929	broad.mit.edu	37	20	36992685	36992685	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:36992685C>T	uc002xic.1	+	7	744	c.709C>T	c.(709-711)CGG>TGG	p.R237W		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	237					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				GGAAGCCCCTCGGGCAACAGC	0.547		NA											9	37					0	0	0	0
SFRS6	6431	broad.mit.edu	37	20	42089355	42089355	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:42089355G>C	uc010zwg.1	+	6	857	c.687G>C	c.(685-687)CGG>CGC	p.R229R	SFRS6_uc002xki.2_Silent_p.R100R|SFRS6_uc002xkk.2_Intron	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	229	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCAGGTCGCGGAGCAAAGGTC	0.438		NA											7	36					0	0	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47649614	47649614	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:47649614G>C	uc002xtx.3	+	39	5388	c.5236G>C	c.(5236-5238)GAC>CAC	p.D1746H	ARFGEF2_uc010zyf.1_Missense_Mutation_p.D1039H	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1746					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TATGCAGTTTGACCTGATCCC	0.418		NA											9	57					0	0	0	0
ZNF217	7764	broad.mit.edu	37	20	52199332	52199332	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:52199332G>A	uc002xwq.3	-	1	305	c.34C>T	c.(34-36)CAA>TAA	p.Q12*	ZNF217_uc010gij.1_Nonsense_Mutation_p.Q4*	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	12					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			AAGAGGGATTGAGTTGGCATG	0.468		NA											15	97					0	0	0	0
DOK5	55816	broad.mit.edu	37	20	53208154	53208154	+	Splice_Site	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:53208154G>C	uc002xwy.2	+	5	630	c.410_splice	c.e5-1	p.E137_splice	DOK5_uc010gin.2_Splice_Site_p.E29_splice|DOK5_uc002xwz.2_Intron	NM_018431	NP_060901	Q9P104	DOK5_HUMAN	docking protein 5								insulin receptor binding			ovary(1)	1			Colorectal(105;0.202)			TTTTCTCCCAGAGAGATTCAA	0.368		NA											5	72					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61525058	61525058	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:61525058C>T	uc002ydr.1	-	12	3325	c.3061G>A	c.(3061-3063)GAC>AAC	p.D1021N	DIDO1_uc002yds.1_Missense_Mutation_p.D1021N|DIDO1_uc002ydt.1_Missense_Mutation_p.D1021N|DIDO1_uc002ydu.1_Missense_Mutation_p.D1021N	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1021					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TATCTTGGGTCAGGAGATGAG	0.483		NA											18	87					0	0	0	0
DIDO1	11083	broad.mit.edu	37	20	61525160	61525160	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr20:61525160C>T	uc002ydr.1	-	12	3223	c.2959G>A	c.(2959-2961)GAC>AAC	p.D987N	DIDO1_uc002yds.1_Missense_Mutation_p.D987N|DIDO1_uc002ydt.1_Missense_Mutation_p.D987N|DIDO1_uc002ydu.1_Missense_Mutation_p.D987N	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	987					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TGGGTGCTGTCTGGGCGGGAT	0.622		NA											16	86					0	0	0	0
CRYZL1	9946	broad.mit.edu	37	21	34994360	34994360	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr21:34994360C>T	uc011adw.1	-	4	339	c.159G>A	c.(157-159)ATG>ATA	p.M53I	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Missense_Mutation_p.M77I|CRYZL1_uc002yss.1_RNA|CRYZL1_uc002yst.1_RNA|CRYZL1_uc002ysu.2_Missense_Mutation_p.M53I	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	53					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						TTTTCATCTTCATTTCTGCCA	0.338		NA											28	119					0	0	0	0
ITSN1	6453	broad.mit.edu	37	21	35166702	35166702	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr21:35166702G>A	uc002yta.1	+	17	2150	c.1882G>A	c.(1882-1884)GAA>AAA	p.E628K	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E628K|ITSN1_uc010gmg.2_Missense_Mutation_p.E591K|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E628K|ITSN1_uc010gmi.2_Missense_Mutation_p.E591K|ITSN1_uc010gmj.2_Missense_Mutation_p.E512K|ITSN1_uc002ysy.2_Missense_Mutation_p.E628K|ITSN1_uc002ysx.2_Missense_Mutation_p.E591K|ITSN1_uc002ytb.1_Missense_Mutation_p.E628K|ITSN1_uc002ytc.1_Missense_Mutation_p.E628K|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E591K|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E628K|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E562K	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	628	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CATGGAGGCTGAACGACTGAA	0.383		NA											12	67					0	0	0	0
RRP1	8568	broad.mit.edu	37	21	45219458	45219458	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr21:45219458C>T	uc002zds.2	+	9	912	c.819C>T	c.(817-819)ATC>ATT	p.I273I	RRP1_uc011aez.1_Silent_p.I273I|RRP1_uc010gpk.1_Silent_p.I123I|RRP1_uc010gpl.1_Silent_p.I171I|RRP1_uc010gpm.1_Silent_p.I140I	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	273					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		CAGGCTCCATCTGCAGGGCTG	0.647		NA											5	45					0	0	0	0
CECR5	27440	broad.mit.edu	37	22	17630458	17630458	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:17630458C>T	uc002zmf.2	-	2	332	c.304G>A	c.(304-306)GAG>AAG	p.E102K	CECR5_uc002zme.2_5'Flank|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Missense_Mutation_p.E72K	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	102							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				GCTGACAGCTCCTGGGCTTTG	0.597		NA											14	95					0	0	0	0
TXNRD2	10587	broad.mit.edu	37	22	19868160	19868160	+	Silent	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:19868160C>A	uc011ahc.1	-	13	1200	c.1167G>T	c.(1165-1167)CTG>CTT	p.L389L	TXNRD2_uc002zql.1_Silent_p.L143L|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Silent_p.L388L|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Silent_p.L39L	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	389					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					CGTAGTCCATCAGATCTGAGG	0.612		NA											4	48					0.00909568	0.00925056	1	0
GGA1	26088	broad.mit.edu	37	22	38028118	38028118	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:38028118G>A	uc003atc.2	+	15	2009	c.1644G>A	c.(1642-1644)CTG>CTA	p.L548L	GGA1_uc003atd.2_Silent_p.L461L|GGA1_uc003ate.2_Silent_p.L544L|GGA1_uc003atf.2_Silent_p.L475L|SH3BP1_uc003atg.1_5'Flank	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	548	GAE.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					TTTCCATGCTGAGCACCGCCC	0.627		NA											3	21					0	0	0	0
ST13	6767	broad.mit.edu	37	22	41240869	41240869	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:41240869G>A	uc003aze.2	-	4	432	c.289C>T	c.(289-291)CAA>TAA	p.Q97*	ST13_uc011aow.1_Nonsense_Mutation_p.Q87*	NM_003932	NP_003923	P50502	F10A1_HUMAN	heat shock 70kD protein binding protein	97							protein binding, bridging				0						CCCATTTCTTGAGGAGCATCA	0.408		NA											5	18					0	0	0	0
WBP2NL	164684	broad.mit.edu	37	22	42423140	42423140	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:42423140C>T	uc011ape.1	+	7	901	c.885C>T	c.(883-885)AAC>AAT	p.N295N	WBP2NL_uc003bbt.2_Silent_p.N295N|WBP2NL_uc011apk.1_Silent_p.N167N|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_RNA	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	295					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						CTCCTGAAAACGAGGCTTCTC	0.527		NA											19	83					0	0	0	0
NUP50	10762	broad.mit.edu	37	22	45571788	45571788	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:45571788G>T	uc003bfr.2	+	4	629	c.167G>T	c.(166-168)GGA>GTA	p.G56V	NUP50_uc003bfs.2_Missense_Mutation_p.G28V|NUP50_uc011aqn.1_Intron|NUP50_uc003bft.2_Missense_Mutation_p.G28V|NUP50_uc011aqo.1_5'Flank	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	56	Gly-rich.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GACACTGGAGGAGCCTTTAAA	0.463		NA											15	95					0.000422831	0.000435765	1	0
FAM118A	55007	broad.mit.edu	37	22	45728405	45728405	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr22:45728405G>A	uc003bfz.3	+	7	1367	c.751G>A	c.(751-753)GTG>ATG	p.V251M	FAM118A_uc003bga.3_Missense_Mutation_p.V251M|FAM118A_uc011aqr.1_Missense_Mutation_p.V69M	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	251						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TCTTTACTCCGTGCCGAATAA	0.478		NA											22	138					0	0	0	0
GADL1	339896	broad.mit.edu	37	3	30885930	30885930	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:30885930G>C	uc003cep.2	-	7	727	c.680C>G	c.(679-681)TCT>TGT	p.S227C	GADL1_uc003ceq.1_Missense_Mutation_p.S227C	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	227					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	CCCAAGAAAAGAGGCTGCCTT	0.433		NA											35	150					0	0	0	0
CLASP2	23122	broad.mit.edu	37	3	33585011	33585011	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:33585011C>T	uc003cfu.2	-	31	3672	c.3318G>A	c.(3316-3318)TTG>TTA	p.L1106L	CLASP2_uc003cfs.2_Silent_p.L313L|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Silent_p.L706L	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1115										ovary(3)|central_nervous_system(1)	4						TTGGTCTTGTCAAAGGACTCC	0.393		NA											13	80					0	0	0	0
SCN5A	6331	broad.mit.edu	37	3	38645426	38645426	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:38645426C>T	uc003cio.2	-	12	1861	c.1667G>A	c.(1666-1668)AGC>AAC	p.S556N	SCN5A_uc003cin.2_Missense_Mutation_p.S556N|SCN5A_uc003cil.3_Missense_Mutation_p.S556N|SCN5A_uc010hhi.2_Missense_Mutation_p.S556N|SCN5A_uc010hhk.2_Missense_Mutation_p.S556N|SCN5A_uc011ayr.1_Missense_Mutation_p.S556N|SCN5A_uc010hhj.1_Missense_Mutation_p.S167N	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	556					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGTGTGGTGGCTCTCGCTCTC	0.642		NA											7	41					0	0	0	0
ULK4	54986	broad.mit.edu	37	3	41973352	41973352	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:41973352C>T	uc003ckv.3	-	5	726	c.525G>A	c.(523-525)ATG>ATA	p.M175I	ULK4_uc003ckw.2_Missense_Mutation_p.M175I|ULK4_uc003ckx.1_Missense_Mutation_p.M175I	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	175	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTCTACTTTTCATGCTTTTCT	0.423		NA											22	185					0	0	0	0
CELSR3	1951	broad.mit.edu	37	3	48669702	48669702	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:48669702G>A	uc003cuf.1	-	41	10776	c.10776C>T	c.(10774-10776)CTC>CTT	p.L3592L	SLC26A6_uc003cug.2_Silent_p.L166L|SLC26A6_uc003cuh.2_Silent_p.L187L|SLC26A6_uc010hke.2_Silent_p.L38L|SLC26A6_uc003cuk.2_Intron|SLC26A6_uc003cui.2_Silent_p.L187L|SLC26A6_uc003cuj.2_Silent_p.L187L|SLC26A6_uc011bbp.1_Intron	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCAGGACACTGAGTGTGGAGG	0.602		NA											15	55					0	0	0	0
QARS	5859	broad.mit.edu	37	3	49136368	49136368	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:49136368G>C	uc003cvx.2	-	19	1818	c.1813C>G	c.(1813-1815)CAG>GAG	p.Q605E	QARS_uc011bcc.1_Missense_Mutation_p.Q58E|QARS_uc011bcd.1_Missense_Mutation_p.Q460E|QARS_uc003cvy.2_Missense_Mutation_p.Q460E|QARS_uc011bce.1_Missense_Mutation_p.Q594E	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	605					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AAGGGAACCTGATGGAAGCCT	0.517		NA											12	50					0	0	0	0
MON1A	84315	broad.mit.edu	37	3	49947847	49947847	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:49947847C>T	uc003cxz.2	-	4	1501	c.1375G>A	c.(1375-1377)GAG>AAG	p.E459K	MON1A_uc003cya.2_Missense_Mutation_p.E297K|MON1A_uc003cyb.2_Missense_Mutation_p.E297K	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	362							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GTCCAGGCCTCGCCCTCGCGA	0.597		NA											6	44					0	0	0	0
HEMK1	51409	broad.mit.edu	37	3	50608743	50608743	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:50608743C>T	uc003dau.2	+	2	504	c.208C>T	c.(208-210)CAT>TAT	p.H70Y	C3orf18_uc003dat.2_5'Flank|HEMK1_uc003dav.2_Missense_Mutation_p.H70Y|HEMK1_uc003daw.2_Missense_Mutation_p.H70Y	NM_016173	NP_057257	Q9Y5R4	HEMK1_HUMAN	HemK methyltransferase family member 1	70					DNA methylation		DNA binding|N-methyltransferase activity|protein methyltransferase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000283)|KIRC - Kidney renal clear cell carcinoma(197;0.0179)|Kidney(197;0.0212)		CATCGTGGCTCATGTCCTTGG	0.522		NA											5	39					0	0	0	0
PCBP4	57060	broad.mit.edu	37	3	51992917	51992917	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:51992917G>A	uc003dcd.1	-	11	1208	c.812C>T	c.(811-813)TCA>TTA	p.S271L	PCBP4_uc003dcb.1_Missense_Mutation_p.S237L|PCBP4_uc003dcc.1_Missense_Mutation_p.S292L|PCBP4_uc003dce.1_Silent_p.V272V|PCBP4_uc003dcf.1_Missense_Mutation_p.S271L|PCBP4_uc003dcg.1_Missense_Mutation_p.S237L|PCBP4_uc003dch.1_Missense_Mutation_p.S271L|PCBP4_uc003dci.1_Missense_Mutation_p.S111L|PCBP4_uc003dcj.1_Missense_Mutation_p.S271L|PCBP4_uc003dck.1_Missense_Mutation_p.S228L|PCBP4_uc003dcl.1_Missense_Mutation_p.S271L	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	271	KH 3.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ATGTGCCCCTGACATCTGCCG	0.612		NA											21	95					0	0	0	0
DUSP7	1849	broad.mit.edu	37	3	52087966	52087966	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:52087966G>C	uc003dct.2	-	2	1021	c.942C>G	c.(940-942)ATC>ATG	p.I314M	DUSP7_uc010hma.2_Missense_Mutation_p.I314M	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	314	Tyrosine-protein phosphatase.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CAATGAAGCTGATGGCCTCAG	0.612		NA											11	62					0	0	0	0
CACNA1D	776	broad.mit.edu	37	3	53531326	53531326	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:53531326C>G	uc003dgv.3	+	2	378	c.215C>G	c.(214-216)TCT>TGT	p.S72C	CACNA1D_uc003dgu.3_Missense_Mutation_p.S72C|CACNA1D_uc003dgy.3_Missense_Mutation_p.S72C	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	72	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATGAGCACCTCTGCACCCCCA	0.547		NA											4	74					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	56173588	56173588	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:56173588G>C	uc003dhr.1	-	6	1678	c.1422C>G	c.(1420-1422)CTC>CTG	p.L474L		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	474	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTGACTCTTTGAGCACTTCAA	0.428		NA											11	48					0	0	0	0
EPHA3	2042	broad.mit.edu	37	3	89259517	89259517	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:89259517C>T	uc003dqy.2	+	3	886	c.661C>T	c.(661-663)CAG>TAG	p.Q221*	EPHA3_uc003dqx.1_Nonsense_Mutation_p.Q221*|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	221	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CATGGACTCCCAGTCCCTGGT	0.478		NA								TSP Lung(6;0.00050)			18	137					0	0	0	0
DIRC2	84925	broad.mit.edu	37	3	122545833	122545833	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:122545833C>T	uc003efw.3	+	3	763	c.624C>T	c.(622-624)CCC>CCT	p.P208P	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Silent_p.P46P	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	208					transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		TTCCAGCTCCCAATGGGACAT	0.458		NA											22	125					0	0	0	0
MYLK	4638	broad.mit.edu	37	3	123419491	123419491	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:123419491C>T	uc003ego.2	-	18	3106	c.2824G>A	c.(2824-2826)GAG>AAG	p.E942K	MYLK_uc011bjw.1_Missense_Mutation_p.E942K|MYLK_uc003egp.2_Missense_Mutation_p.E873K|MYLK_uc003egq.2_Missense_Mutation_p.E942K|MYLK_uc003egr.2_Missense_Mutation_p.E873K|MYLK_uc003egs.2_Missense_Mutation_p.E766K|MYLK_uc003egt.2_Missense_Mutation_p.E133K	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	942	Actin-binding (calcium/calmodulin- sensitive) (By similarity).|5 X 28 AA approximate tandem repeats.|1-3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACCTTCCTCTCTTCCTCAGAC	0.587		NA											11	70					0	0	0	0
TMCC1	23023	broad.mit.edu	37	3	129389903	129389903	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:129389903C>T	uc003emz.3	-	5	1282	c.781G>A	c.(781-783)GAA>AAA	p.E261K	TMCC1_uc003emy.3_5'UTR|TMCC1_uc011blc.1_Missense_Mutation_p.E82K|TMCC1_uc010htg.2_Missense_Mutation_p.E147K	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	261	Potential.					integral to membrane				skin(1)	1						TTCAAGTATTCAGCAACGTTG	0.498		NA											45	214					0	0	0	0
RAB6B	51560	broad.mit.edu	37	3	133553479	133553479	+	Nonsense_Mutation	SNP	G	G	A	rs147187493		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:133553479G>A	uc003epy.2	-	7	883	c.502C>T	c.(502-504)CGA>TGA	p.R168*	RAB6B_uc011blu.1_Nonsense_Mutation_p.R155*	NM_016577	NP_057661	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	168					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			pancreas(1)	1						GCCACACGTCGAAAAAGCTGG	0.522		NA											16	70					0	0	0	0
A4GNT	51146	broad.mit.edu	37	3	137843367	137843367	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:137843367G>A	uc003ers.2	-	3	964	c.762C>T	c.(760-762)TTC>TTT	p.F254F		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	254	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GGGGGTGTAAGAAGGATATGT	0.493		NA											21	73					0	0	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277609	140277609	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:140277609G>C	uc003etn.2	+	12	2141	c.1951G>C	c.(1951-1953)GAA>CAA	p.E651Q		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	651	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TGCCCAGTTTGAAAGTGCCAG	0.582		NA								HNSCC(16;0.037)			8	50					0	0	0	0
ATP1B3	483	broad.mit.edu	37	3	141626075	141626075	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:141626075C>T	uc003eug.1	+	3	479	c.305C>T	c.(304-306)TCG>TTG	p.S102L	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Missense_Mutation_p.S88L	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	102	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						GATCCAACTTCGTATGCAGGG	0.343		NA											8	52					0	0	0	0
PLOD2	5352	broad.mit.edu	37	3	145789109	145789109	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:145789109G>A	uc003evs.1	-	17	2393	c.1887C>T	c.(1885-1887)TTC>TTT	p.F629F	PLOD2_uc003evq.1_Silent_p.F310F|PLOD2_uc011bnm.1_Silent_p.F595F|PLOD2_uc003evr.1_Silent_p.F650F	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	629					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	CTGGTGCAATGAACTCCCGGA	0.418		NA											9	77					0	0	0	0
AADAC	13	broad.mit.edu	37	3	151545802	151545802	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:151545802G>A	uc003eze.2	+	5	1132	c.1042G>A	c.(1042-1044)GAT>AAT	p.D348N		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	348	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CTTAAGAGATGATGGACTCAT	0.468		NA											13	87					0	0	0	0
MME	4311	broad.mit.edu	37	3	154860103	154860103	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:154860103G>C	uc010hvr.1	+	12	1383	c.1172G>C	c.(1171-1173)AGA>ACA	p.R391T	MME_uc003fab.1_Missense_Mutation_p.R391T|MME_uc003fac.1_Missense_Mutation_p.R391T|MME_uc003fad.1_Missense_Mutation_p.R391T|MME_uc003fae.1_Missense_Mutation_p.R391T	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	391	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AAGGAGTCCAGAAATGCTTTC	0.393		NA											14	87					0	0	0	0
PLCH1	23007	broad.mit.edu	37	3	155199669	155199669	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:155199669G>C	uc011bok.1	-	23	4447	c.4170C>G	c.(4168-4170)CTC>CTG	p.L1390L	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.L1352L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1390					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GATTGTACTTGAGTTTTAAAG	0.418		NA											6	75					0	0	0	0
MECOM	2122	broad.mit.edu	37	3	168834418	168834418	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:168834418G>C	uc003ffi.3	-	7	947	c.678C>G	c.(676-678)TTC>TTG	p.F226L	MECOM_uc010hwk.1_Missense_Mutation_p.F249L|MECOM_uc003ffj.3_Missense_Mutation_p.F291L|MECOM_uc011bpi.1_Missense_Mutation_p.F227L|MECOM_uc003ffn.3_Missense_Mutation_p.F226L|MECOM_uc003ffk.2_Missense_Mutation_p.F226L|MECOM_uc003ffl.2_Missense_Mutation_p.F386L|MECOM_uc011bpj.1_Missense_Mutation_p.F414L|MECOM_uc011bpk.1_Missense_Mutation_p.F216L|MECOM_uc010hwn.2_Missense_Mutation_p.F414L	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	226	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 7.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						ACGTAGTGCTGAACATTTGTC	0.438		NA											14	126					0	0	0	0
SAMD7	344658	broad.mit.edu	37	3	169644598	169644598	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:169644598G>A	uc003fgd.2	+	6	815	c.548G>A	c.(547-549)CGA>CAA	p.R183Q	SAMD7_uc003fge.2_Missense_Mutation_p.R183Q|SAMD7_uc011bpo.1_Missense_Mutation_p.R84Q	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	183										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGATGTCGTCGACTCAGGAAA	0.478		NA											10	75					0	0	0	0
KLHL24	54800	broad.mit.edu	37	3	183368194	183368194	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:183368194G>A	uc003flv.2	+	3	345	c.50G>A	c.(49-51)CGT>CAT	p.R17H	KLHL24_uc003flw.2_Missense_Mutation_p.R17H|KLHL24_uc003flx.2_Missense_Mutation_p.R17H	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	17						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CTTGGGGTGCGTGATTCCCCA	0.408		NA											7	59					0	0	0	0
ECE2	9718	broad.mit.edu	37	3	183996310	183996310	+	Silent	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:183996310C>A	uc003fni.3	+	7	1173	c.1135C>A	c.(1135-1137)CGG>AGG	p.R379R	ECE2_uc011brg.1_Silent_p.R307R|ECE2_uc011brh.1_Silent_p.R232R|ECE2_uc003fnl.3_Silent_p.R307R|ECE2_uc003fnm.3_Silent_p.R261R|ECE2_uc003fnk.3_Silent_p.R232R|ECE2_uc011bri.1_Silent_p.R294R|ECE2_uc010hxv.2_Intron	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	379	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTGCCCTCTCGGGATTACTA	0.552		NA											21	113					7.45e-12	7.96e-12	1	0
PSMD2	5708	broad.mit.edu	37	3	184022098	184022098	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:184022098C>T	uc003fnn.1	+	12	1491	c.1458C>T	c.(1456-1458)GGC>GGT	p.G486G	PSMD2_uc011brj.1_Silent_p.G327G|PSMD2_uc011brk.1_Silent_p.G356G	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	486	PC 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GCAGGCTAGGCTTGGCTTATG	0.458		NA											51	137					0	0	0	0
EIF4G1	1981	broad.mit.edu	37	3	184046444	184046444	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:184046444G>A	uc003fnp.2	+	27	4177	c.3979G>A	c.(3979-3981)GAG>AAG	p.E1327K	EIF4G1_uc003fnt.2_Missense_Mutation_p.E1038K|EIF4G1_uc003fnq.2_Missense_Mutation_p.E1240K|EIF4G1_uc003fnr.2_Missense_Mutation_p.E1163K|EIF4G1_uc010hxx.2_Missense_Mutation_p.E1334K|EIF4G1_uc003fns.2_Missense_Mutation_p.E1287K|EIF4G1_uc010hxy.2_Missense_Mutation_p.E1334K|EIF4G1_uc003fnv.3_Missense_Mutation_p.E1328K|EIF4G1_uc003fnu.3_Missense_Mutation_p.E1327K|EIF4G1_uc003fnw.2_Missense_Mutation_p.E1334K|EIF4G1_uc003fnx.2_Missense_Mutation_p.E1132K|EIF4G1_uc003fny.3_Missense_Mutation_p.E1131K|EIF4G1_uc003foa.2_5'UTR	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1327	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAATTGGCTGAGGACATGGA	0.537		NA											31	187					0	0	0	0
ETV5	2119	broad.mit.edu	37	3	185823423	185823423	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:185823423C>T	uc003fpz.2	-	3	371	c.124G>A	c.(124-126)GAT>AAT	p.D42N	ETV5_uc003fpy.2_Missense_Mutation_p.D84N	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	42					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			CCTTCAGAATCGTGAGCCAGA	0.478		NA	T	TMPRSS2|SCL45A3	Prostate 								9	106					0	0	0	0
KNG1	3827	broad.mit.edu	37	3	186450325	186450325	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:186450325C>T	uc011bsa.1	+	7	1004	c.792C>T	c.(790-792)TGC>TGT	p.C264C	KNG1_uc003fqr.2_Silent_p.C264C	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	264	Cystatin 3.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CCAAGATTTGCGTGGGCTGCC	0.488		NA											21	127					0	0	0	0
ATP13A4	84239	broad.mit.edu	37	3	193185238	193185238	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:193185238C>T	uc003ftd.2	-	10	1089	c.981G>A	c.(979-981)AAG>AAA	p.K327K	ATP13A4_uc003fte.1_Silent_p.K327K|ATP13A4_uc011bsr.1_5'UTR|ATP13A4_uc010hzi.2_RNA|ATP13A4_uc003ftf.3_Silent_p.K33K	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	327	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AGCTATCCATCTTGGGTAACG	0.478		NA											15	137					0	0	0	0
APOD	347	broad.mit.edu	37	3	195306307	195306307	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:195306307G>A	uc003fur.2	-	2	388	c.26C>T	c.(25-27)TCC>TTC	p.S9F	APOD_uc011bsx.1_Missense_Mutation_p.S9F	NM_001647	NP_001638	P05090	APOD_HUMAN	apolipoprotein D precursor	9					lipid metabolic process	extracellular space	lipid binding|lipid transporter activity|protein binding			ovary(2)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		AGCCAGTGCGGAAAGCAGCAG	0.577		NA											6	55					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597		NA											5	5					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195511937	195511937	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:195511937C>T	uc011bto.1	-	2	6974	c.6514G>A	c.(6514-6516)GGT>AGT	p.G2172S	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGGCGTGACCTGTGGATGCT	0.577		NA											2	0					0	0	0	0
WDR53	348793	broad.mit.edu	37	3	196288262	196288262	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196288262C>G	uc003fwt.2	-	3	556	c.85G>C	c.(85-87)GAG>CAG	p.E29Q		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	29	WD 1.									breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TCTCCGCCCTCTGCTCCAGAA	0.542		NA											7	38					0	0	0	0
WDR53	348793	broad.mit.edu	37	3	196288299	196288299	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196288299C>G	uc003fwt.2	-	3	519	c.48G>C	c.(46-48)CTG>CTC	p.L16L		NM_182627	NP_872433	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	16	WD 1.									breast(1)|skin(1)	2	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TACTTGCATTCAGGCAGAGGA	0.532		NA											9	45					0	0	0	0
C3orf34	84984	broad.mit.edu	37	3	196434703	196434703	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196434703C>T	uc011btw.1	-	3	605	c.223G>A	c.(223-225)GAG>AAG	p.E75K		NM_032898	NP_116287	Q96LK0	CEP19_HUMAN	hypothetical protein LOC84984	71						centriole|spindle pole					0	all_cancers(143;1.48e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00301)		AATAGCTTCTCTAGCTGCCTC	0.438		NA											32	155					0	0	0	0
PAK2	5062	broad.mit.edu	37	3	196534686	196534686	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196534686G>A	uc003fwy.3	+	7	932	c.610G>A	c.(610-612)GCA>ACA	p.A204T		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	204					axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		CCCTGTTCCTGCACCAGTTGG	0.393		NA											8	90					0	0	0	0
SENP5	205564	broad.mit.edu	37	3	196626904	196626904	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr3:196626904C>G	uc003fwz.3	+	4	1978	c.1729C>G	c.(1729-1731)CTG>GTG	p.L577V	SENP5_uc011bty.1_Missense_Mutation_p.L577V	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	577	Protease.				cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		CCTGGCGACTCTGGATGGTCA	0.383		NA											13	70					0	0	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				4	16					0	0	0	0
TNIP2	79155	broad.mit.edu	37	4	2746559	2746559	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:2746559C>T	uc003gfg.2	-	4	858	c.771G>A	c.(769-771)ATG>ATA	p.M257I	TNIP2_uc003gff.2_Missense_Mutation_p.M150I|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	257	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCTCCTTCCTCATCAGCTCGG	0.612		NA											19	72					0	0	0	0
LAP3	51056	broad.mit.edu	37	4	17583385	17583385	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:17583385C>T	uc003gph.1	+	3	383	c.221C>T	c.(220-222)TCT>TTT	p.S74F	LAP3_uc010ieg.2_Missense_Mutation_p.S74F	NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	74					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						TGTTTTAGATCTGGACCACCT	0.358		NA											12	74					0	0	0	0
GABRB1	2560	broad.mit.edu	37	4	47427752	47427752	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:47427752C>T	uc003gxh.2	+	9	1516	c.1142C>T	c.(1141-1143)TCG>TTG	p.S381L	GABRB1_uc011bze.1_Missense_Mutation_p.S311L	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	381	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACGAGTGGCTCGGAAGTGCTC	0.597		NA											10	59					0	0	0	0
CWH43	80157	broad.mit.edu	37	4	49034613	49034613	+	Silent	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:49034613G>T	uc003gyv.2	+	12	1721	c.1539G>T	c.(1537-1539)GTG>GTT	p.V513V	CWH43_uc011bzl.1_Silent_p.V486V	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	513					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						ACCCAATTGTGAAATCTGAGC	0.468		NA											38	204					2.41e-17	2.58e-17	1	0
AASDH	132949	broad.mit.edu	37	4	57244556	57244556	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:57244556G>A	uc003hbn.2	-	4	579	c.426C>T	c.(424-426)TTC>TTT	p.F142F	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_5'UTR|AASDH_uc003hbo.2_Silent_p.F42F|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Silent_p.F142F|AASDH_uc003hbp.2_Silent_p.F142F	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	142					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				AGTGAAGTCTGAAGAGCACTA	0.313		NA											6	49					0	0	0	0
YTHDC1	91746	broad.mit.edu	37	4	69203024	69203024	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:69203024C>T	uc003hdx.2	-	4	957	c.604G>A	c.(604-606)GAG>AAG	p.E202K	YTHDC1_uc003hdy.2_Missense_Mutation_p.E202K	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	202	Glu-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						actccttcctcctcATTCTCA	0.219		NA											5	35					0	0	0	0
FRAS1	80144	broad.mit.edu	37	4	79328882	79328882	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:79328882G>C	uc003hlb.2	+	31	4635	c.4195G>C	c.(4195-4197)GAT>CAT	p.D1399H	FRAS1_uc003hkw.2_Missense_Mutation_p.D1399H	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1398	CSPG 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GCACCTGCCTGATGGGAGGAC	0.587		NA											8	56					0	0	0	0
FRAS1	80144	broad.mit.edu	37	4	79461904	79461904	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:79461904G>A	uc003hlb.2	+	74	12105	c.11665G>A	c.(11665-11667)GAG>AAG	p.E3889K		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3884	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CCTGAATCTGGAGATGCAAGA	0.517		NA											4	22					0	0	0	0
ABCG2	9429	broad.mit.edu	37	4	89052248	89052248	+	Missense_Mutation	SNP	G	G	C	rs1061017		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:89052248G>C	uc003hrg.2	-	5	989	c.496C>G	c.(496-498)CAA>GAA	p.Q166E	ABCG2_uc003hrh.2_Missense_Mutation_p.Q166E|ABCG2_uc003hrf.2_Missense_Mutation_p.Q36E	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	166	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	CCTAACTCTTGAATGACCCTG	0.418		NA											27	161					0	0	0	0
LRIT3	345193	broad.mit.edu	37	4	110791623	110791623	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:110791623G>A	uc003hzx.3	+	3	1776	c.1583G>A	c.(1582-1584)AGA>AAA	p.R528K	LRIT3_uc003hzw.3_Missense_Mutation_p.R390K	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	528	Fibronectin type-III.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TCTACTGAAAGAGTTGAAGGA	0.453		NA											17	65					0	0	0	0
KIAA1109	84162	broad.mit.edu	37	4	123161431	123161431	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:123161431C>T	uc003ieh.2	+	27	4639	c.4594C>T	c.(4594-4596)CGT>TGT	p.R1532C	KIAA1109_uc003iei.1_Missense_Mutation_p.R1285C|KIAA1109_uc010ins.1_Missense_Mutation_p.R875C|KIAA1109_uc003iek.2_Missense_Mutation_p.R151C	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1532					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTCATTGCATCGTCCCCTTGA	0.383		NA											15	77					0	0	0	0
RNF150	57484	broad.mit.edu	37	4	142053860	142053860	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:142053860C>G	uc003iio.1	-	1	757	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	RNF150_uc010iok.1_Missense_Mutation_p.E35Q|RNF150_uc003iip.1_Missense_Mutation_p.E35Q	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	35	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					TCCTCCTTCTCGGCCACGGTA	0.418		NA											8	44					0	0	0	0
NR3C2	4306	broad.mit.edu	37	4	149357542	149357542	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:149357542C>T	uc003ilj.3	-	2	805	c.471G>A	c.(469-471)GTG>GTA	p.V157V	NR3C2_uc003ilk.3_Silent_p.V157V|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	157	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	AGGGCGTGTTCACACAACTTA	0.448		NA											16	132					0	0	0	0
KIAA0922	23240	broad.mit.edu	37	4	154553947	154553947	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:154553947G>A	uc003inm.3	+	32	4334	c.4282G>A	c.(4282-4284)GGC>AGC	p.G1428S	KIAA0922_uc010ipp.2_Missense_Mutation_p.G1429S|KIAA0922_uc010ipq.2_Missense_Mutation_p.G1197S	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1428	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CCTGGAGAACGGCGTGCCTTG	0.532		NA											11	51					0	0	0	0
FNIP2	57600	broad.mit.edu	37	4	159790180	159790180	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr4:159790180G>C	uc003iqe.3	+	13	2575	c.2392G>C	c.(2392-2394)GAC>CAC	p.D798H		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	798	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TTTTGCAGAGGACAGAGGCAG	0.562		NA											13	143					0	0	0	0
CDH10	1008	broad.mit.edu	37	5	24537725	24537725	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:24537725C>A	uc003jgr.1	-	3	622	c.290G>T	c.(289-291)GGA>GTA	p.G97V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	97	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGTACCAGCTCCATCTCCAGA	0.363		NA								HNSCC(23;0.051)			9	58					7.48e-07	7.87e-07	1	0
RXFP3	51289	broad.mit.edu	37	5	33938124	33938124	+	Missense_Mutation	SNP	G	G	A	rs138975968		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:33938124G>A	uc003jic.1	+	1	1636	c.1279G>A	c.(1279-1281)GAG>AAG	p.E427K		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	427	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						GCCGGAGCACGAGGATCAGGG	0.567		NA											6	23					0	0	0	0
LMBRD2	92255	broad.mit.edu	37	5	36122457	36122457	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:36122457G>A	uc003jkb.1	-	9	1460	c.1045C>T	c.(1045-1047)CAT>TAT	p.H349Y		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	349	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACAAACTGATGAGTAGCACTA	0.333		NA											10	41					0	0	0	0
GDNF	2668	broad.mit.edu	37	5	37815932	37815932	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:37815932C>G	uc011cpi.1	-	3	657	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	GDNF_uc011cpc.1_Missense_Mutation_p.E75Q|GDNF_uc011cpd.1_Missense_Mutation_p.E101Q|GDNF_uc011cpe.1_Missense_Mutation_p.E127Q|GDNF_uc011cpf.1_Missense_Mutation_p.E127Q|GDNF_uc011cpg.1_Missense_Mutation_p.E170Q|GDNF_uc011cph.1_Missense_Mutation_p.E144Q	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	153					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					TACGTTGTCTCAGCTGCATCG	0.443		NA											10	86					0	0	0	0
OSMR	9180	broad.mit.edu	37	5	38883988	38883988	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:38883988G>A	uc003jln.1	+	5	845	c.478G>A	c.(478-480)GAA>AAA	p.E160K	OSMR_uc003jlm.1_Missense_Mutation_p.E160K	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	160	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GCTGGTGGAAGAAGGCACCAA	0.363		NA											8	90					0	0	0	0
PARP8	79668	broad.mit.edu	37	5	50091252	50091252	+	Splice_Site	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:50091252G>A	uc003jon.3	+	13	1610	c.1428_splice	c.e13+1	p.A476_splice	PARP8_uc011cpz.1_Splice_Site_p.A368_splice|PARP8_uc003joo.2_Splice_Site_p.A476_splice|PARP8_uc003jop.2_Splice_Site_p.A476_splice	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				TCAGCTTGCTGTGCGTAAATA	0.393		NA											10	53					0	0	0	0
MAST4	375449	broad.mit.edu	37	5	66458527	66458527	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:66458527C>T	uc003jut.1	+	27	3379	c.3311C>T	c.(3310-3312)TCG>TTG	p.S1104L	MAST4_uc003juw.2_Missense_Mutation_p.S1032L	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1296	Ser-rich.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TCCCTGTCATCGGGTGAGAGC	0.542		NA											11	86					0	0	0	0
MAST4	375449	broad.mit.edu	37	5	66460113	66460113	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:66460113C>T	uc003jut.1	+	28	4607	c.4539C>T	c.(4537-4539)CTC>CTT	p.L1513L	MAST4_uc003juw.2_Silent_p.L1441L|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1705						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGGACAACCTCTGCCCTGTGC	0.577		NA											7	24					0	0	0	0
RAD17	5884	broad.mit.edu	37	5	68669684	68669684	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:68669684G>C	uc003jwo.2	+	2	132	c.70G>C	c.(70-72)GAT>CAT	p.D24H	RAD17_uc003jwg.2_Missense_Mutation_p.D13H|RAD17_uc003jwh.2_Missense_Mutation_p.D13H|RAD17_uc003jwi.2_Missense_Mutation_p.D13H|RAD17_uc003jwj.2_Missense_Mutation_p.D13H|RAD17_uc003jwk.2_Missense_Mutation_p.D13H|RAD17_uc003jwl.2_Missense_Mutation_p.D13H|RAD17_uc003jwm.2_5'UTR|RAD17_uc003jwn.2_Intron	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	24					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		CCCATCATTTGATGATTTTCT	0.358		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					13	73					0	0	0	0
RAD17	5884	broad.mit.edu	37	5	68669849	68669849	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:68669849G>C	uc003jwo.2	+	2	297	c.235G>C	c.(235-237)GAA>CAA	p.E79Q	RAD17_uc003jwg.2_Missense_Mutation_p.E68Q|RAD17_uc003jwh.2_Missense_Mutation_p.E68Q|RAD17_uc003jwi.2_Missense_Mutation_p.E68Q|RAD17_uc003jwj.2_Missense_Mutation_p.E68Q|RAD17_uc003jwk.2_Missense_Mutation_p.E68Q|RAD17_uc003jwl.2_Missense_Mutation_p.E68Q|RAD17_uc003jwm.2_5'UTR|RAD17_uc003jwn.2_Intron	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	79					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TTATGGTTTAGAAAATTCAAA	0.333		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					8	77					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	90041440	90041440	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:90041440G>C	uc003kju.2	+	52	10898	c.10802G>C	c.(10801-10803)AGA>ACA	p.R3601T	GPR98_uc003kjt.2_Missense_Mutation_p.R1307T|GPR98_uc003kjv.2_Missense_Mutation_p.R1201T	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3601	Calx-beta 23.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTGGTGAGAGAGAAGCTACA	0.333		NA											12	56					0	0	0	0
TTC37	9652	broad.mit.edu	37	5	94849302	94849302	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:94849302G>C	uc003klb.2	-	27	3021	c.2751C>G	c.(2749-2751)TTC>TTG	p.F917L		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	917							binding			ovary(3)|pancreas(1)	4						TAGTGTGCCTGAAGAGATCCA	0.338		NA											11	116					0	0	0	0
FBN2	2201	broad.mit.edu	37	5	127653955	127653955	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:127653955C>G	uc003kuu.2	-	36	5042	c.4603G>C	c.(4603-4605)GAG>CAG	p.E1535Q		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1535	EGF-like 26; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCTGCACACTCATCAATATCT	0.423		NA											23	131					0	0	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130857157	130857157	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:130857157G>A	uc003kvn.1	-	7	759	c.553C>T	c.(553-555)CAT>TAT	p.H185Y	RAPGEF6_uc003kvp.1_Missense_Mutation_p.H235Y|RAPGEF6_uc003kvo.1_Missense_Mutation_p.H185Y|RAPGEF6_uc010jdi.1_Missense_Mutation_p.H185Y|RAPGEF6_uc010jdj.1_Missense_Mutation_p.H185Y|RAPGEF6_uc003kvr.2_Missense_Mutation_p.H185Y|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.H185Y	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	185					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		GAAGACACATGAGTCACCTGT	0.383		NA											8	59					0	0	0	0
SLC22A4	6583	broad.mit.edu	37	5	131679482	131679482	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:131679482C>T	uc003kwq.2	+	10	1775	c.1610C>T	c.(1609-1611)TCA>TTA	p.S537L	uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	537	Cytoplasmic (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ACAAGAGACTCAATGGAGACA	0.343		NA											6	26					0	0	0	0
PKD2L2	27039	broad.mit.edu	37	5	137271509	137271509	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:137271509G>A	uc003lby.2	+	13	1751	c.1695G>A	c.(1693-1695)ATG>ATA	p.M565I	PKD2L2_uc003lbw.1_Missense_Mutation_p.M565I|PKD2L2_uc003lbx.2_Missense_Mutation_p.M464I|PKD2L2_uc011cyi.1_Missense_Mutation_p.M173I	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	565	Cytoplasmic (Potential).|Potential.					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGAGCAGATGAAAAAATGGA	0.398		NA											6	44					0	0	0	0
ETF1	2107	broad.mit.edu	37	5	137847221	137847221	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:137847221C>G	uc003ldc.3	-	7	970	c.805G>C	c.(805-807)GAG>CAG	p.E269Q	ETF1_uc011cyv.1_Missense_Mutation_p.E255Q|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Missense_Mutation_p.E236Q|ETF1_uc010jey.1_Missense_Mutation_p.E75Q	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	269					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTAGATAACTCAATAGCTTGG	0.299		NA											8	41					0	0	0	0
SLC4A9	83697	broad.mit.edu	37	5	139745140	139745140	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:139745140G>C	uc003lfm.2	+	12	1794	c.1759G>C	c.(1759-1761)GAC>CAC	p.D587H	SLC4A9_uc003lfj.2_Missense_Mutation_p.D563H|SLC4A9_uc011czg.1_Missense_Mutation_p.D563H|SLC4A9_uc003lfl.2_Missense_Mutation_p.D563H|SLC4A9_uc003lfk.2_Missense_Mutation_p.D552H	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	587	Extracellular (Potential).|Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGCCAAAAGACAGAGACGA	0.507		NA											7	20					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167978	140167978	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:140167978C>T	uc003lhb.2	+	1	2103	c.2103C>T	c.(2101-2103)ATC>ATT	p.I701I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.I701I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	701	Helical; (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACCTGATCATCGCCATCT	0.682		NA											19	78					0	0	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208515	140208515	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:140208515C>G	uc003lho.2	+	1	866	c.839C>G	c.(838-840)TCT>TGT	p.S280C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.S280C|PCDHA6_uc011dab.1_Missense_Mutation_p.S280C	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	280	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTCATATTCTTTTAATAGC	0.388		NA											20	92					0	0	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754586	140754586	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:140754586G>C	uc003ljy.1	+	1	936	c.936G>C	c.(934-936)TCG>TCC	p.S312S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.S312S	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	312	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGGACTCGAGTTTTTATG	0.393		NA											32	148					0	0	0	0
FAT2	2196	broad.mit.edu	37	5	150897219	150897219	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:150897219G>A	uc003lue.3	-	19	11438	c.11425C>T	c.(11425-11427)CTT>TTT	p.L3809F	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.L502F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3809	Extracellular (Potential).|Laminin G-like.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGAATAGAAGAATGGCCTGT	0.552		NA											10	65					0	0	0	0
KIF4B	285643	broad.mit.edu	37	5	154393878	154393878	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:154393878C>A	uc010jih.1	+	1	619	c.459C>A	c.(457-459)TGC>TGA	p.C153*		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	153	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATCTTCTATGCCCATCTCGTG	0.358		NA											22	145					1.98e-07	2.09e-07	1	0
C5orf41	153222	broad.mit.edu	37	5	172560701	172560701	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:172560701C>T	uc003mch.2	+	9	2177	c.1873C>T	c.(1873-1875)CCC>TCC	p.P625S	C5orf41_uc011dfd.1_Missense_Mutation_p.P625S	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	625							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGAAGGGAATCCCACTGGAGG	0.443		NA											10	40					0	0	0	0
NKX2-5	1482	broad.mit.edu	37	5	172660137	172660137	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:172660137C>G	uc003mcm.1	-	2	586	c.410G>C	c.(409-411)CGG>CCG	p.R137P	NKX2-5_uc011dfe.1_3'UTR|NKX2-5_uc010jjt.1_3'UTR	NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	137					adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CTTCCTCCGCCGTCGCGCCCG	0.692		NA											3	11					0	0	0	0
NSD1	64324	broad.mit.edu	37	5	176673765	176673765	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:176673765G>A	uc003mfr.3	+	10	4603	c.4465G>A	c.(4465-4467)GAT>AAT	p.D1489N	NSD1_uc003mft.3_Missense_Mutation_p.D1220N|NSD1_uc003mfs.1_Missense_Mutation_p.D1386N|NSD1_uc011dfx.1_Missense_Mutation_p.D1137N	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1489					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGTGAAAAATGATGACTCGTC	0.438		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			13	54					0	0	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179302008	179302008	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr5:179302008C>T	uc003mlh.2	-	12	2117	c.2080G>A	c.(2080-2082)GAG>AAG	p.E694K	TBC1D9B_uc003mli.2_Missense_Mutation_p.E694K|TBC1D9B_uc003mlj.2_Missense_Mutation_p.E694K|TBC1D9B_uc011dgv.1_5'Flank	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	694	Rab-GAP TBC.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGATGCCCTCATAGAAAAAG	0.622		NA											10	49					0	0	0	0
DSP	1832	broad.mit.edu	37	6	7559514	7559514	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:7559514C>G	uc003mxp.1	+	4	757	c.478C>G	c.(478-480)CGA>GGA	p.R160G	DSP_uc003mxq.1_Missense_Mutation_p.R160G	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	160	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGTGTCCCTCGAGTCCGCAG	0.507		NA											25	157					0	0	0	0
DSP	1832	broad.mit.edu	37	6	7566622	7566622	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:7566622C>T	uc003mxp.1	+	8	1231	c.952C>T	c.(952-954)CAA>TAA	p.Q318*	DSP_uc003mxq.1_Nonsense_Mutation_p.Q318*	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	318	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACGCATGAGTCAACTGGAAGT	0.373		NA											9	63					0	0	0	0
DSP	1832	broad.mit.edu	37	6	7570715	7570715	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:7570715C>T	uc003mxp.1	+	13	1899	c.1620C>T	c.(1618-1620)CTC>CTT	p.L540L	DSP_uc003mxq.1_Silent_p.L540L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	540	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGAACCAGCTCTACATCAACA	0.498		NA											24	114					0	0	0	0
HIST1H2AC	8334	broad.mit.edu	37	6	26124697	26124697	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:26124697C>T	uc003ngm.2	+	1	325	c.237C>T	c.(235-237)ATC>ATT	p.I79I	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Silent_p.I79I	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	79					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGACTCGCATCATCCCGCGCC	0.642		NA											21	109					0	0	0	0
BTN3A1	11119	broad.mit.edu	37	6	26413881	26413881	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:26413881G>C	uc003nhv.2	+	10	1871	c.1503G>C	c.(1501-1503)TTG>TTC	p.L501F	BTN3A1_uc011dkj.1_3'UTR|BTN3A1_uc011dkk.1_Missense_Mutation_p.L449F|BTN3A1_uc010jqj.2_3'UTR	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	501	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TCAGAATTTTGACCTTGGAGC	0.463		NA											18	121					0	0	0	0
BTN2A1	11120	broad.mit.edu	37	6	26463541	26463541	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:26463541C>T	uc003nib.1	+	4	712	c.500C>T	c.(499-501)TCT>TTT	p.S167F	BTN2A1_uc003nic.1_Missense_Mutation_p.S167F|BTN2A1_uc003nid.1_Missense_Mutation_p.S15F|BTN2A1_uc011dko.1_Missense_Mutation_p.S106F|BTN2A1_uc010jqk.1_5'Flank	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	167	Extracellular (Potential).				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						GAGTGCATATCTAGAGGGTGG	0.587		NA											9	74					0	0	0	0
HIST1H3I	8354	broad.mit.edu	37	6	27839889	27839889	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:27839889G>A	uc003njy.2	-	1	211	c.205C>T	c.(205-207)CAG>TAG	p.Q69*		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	69					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						ACCAAGCGCTGAAAAGGTAGC	0.637		NA											32	92					0	0	0	0
CDSN	1041	broad.mit.edu	37	6	31084503	31084503	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31084503C>T	uc003nsm.1	-	2	916	c.889G>A	c.(889-891)GAG>AAG	p.E297K	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	297	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						CCCACCACCTCGTAGCCACCA	0.547		NA											5	41					0	0	0	0
HLA-B	3106	broad.mit.edu	37	6	31324665	31324665	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31324665G>T	uc003nth.2	-	2	197	c.143C>A	c.(142-144)TCA>TAA	p.S48*	HLA-C_uc003ntb.2_5'Flank|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_5'Flank|HLA-B_uc011dnk.1_5'Flank|HLA-B_uc003ntf.2_Nonsense_Mutation_p.S48*|HLA-B_uc003ntg.1_5'Flank|HLA-B_uc003nti.1_5'Flank|HLA-B_uc010jsn.1_5'Flank|HLA-B_uc010jso.2_Nonsense_Mutation_p.S20*	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	48	Alpha-1.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						GTAGCCCACTGAGATGAAGCG	0.697		NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				8	24					5.18e-06	5.43e-06	1	0
C6orf47	57827	broad.mit.edu	37	6	31627496	31627496	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31627496C>T	uc003nvm.1	-	1	1054	c.229G>A	c.(229-231)GAG>AAG	p.E77K		NM_021184	NP_067007	O95873	CF047_HUMAN	G4 protein	77										ovary(1)	1						ACTTGGGGCTCCTCCTTGCTT	0.562		NA											4	48					0	0	0	0
EHMT2	10919	broad.mit.edu	37	6	31856391	31856391	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:31856391C>G	uc003nxz.1	-	11	1360	c.1350G>C	c.(1348-1350)GAG>GAC	p.E450D	EHMT2_uc003nxy.1_Missense_Mutation_p.E241D|EHMT2_uc011don.1_Missense_Mutation_p.E473D|EHMT2_uc003nya.1_Missense_Mutation_p.E416D	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	450					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CGTCCACACTCTCAGTGGCCA	0.662		NA											4	31					0	0	0	0
TNXB	7148	broad.mit.edu	37	6	32050002	32050002	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:32050002C>T	uc003nzl.2	-	9	3749	c.3547G>A	c.(3547-3549)GAG>AAG	p.E1183K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1270	Fibronectin type-III 5.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AACTGGCCCTCAGGGACAGTC	0.602		NA											5	47					0	0	0	0
ITPR3	3710	broad.mit.edu	37	6	33660549	33660549	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:33660549C>T	uc011drk.1	+	55	7722	c.7503C>T	c.(7501-7503)TTC>TTT	p.F2501F	ITPR3_uc003oey.2_Silent_p.F588F	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2501	Helical; (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCCTGTTCTTCTTCATCGTCA	0.547		NA											17	87					0	0	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34839420	34839420	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:34839420G>A	uc003oju.3	+	19	4275	c.4041G>A	c.(4039-4041)ATG>ATA	p.M1347I	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1347										ovary(3)	3						CTCTGGCCATGGAACATGTTG	0.522		NA											10	53					0	0	0	0
MTCH1	23787	broad.mit.edu	37	6	36938202	36938202	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:36938202G>A	uc003ond.1	-	10	1002	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	MTCH1_uc003onc.1_Silent_p.L317L|MTCH1_uc010jwo.1_RNA|MTCH1_uc003one.3_Silent_p.L334L|MTCH1_uc011dtt.1_Silent_p.L149L	NM_014341	NP_055156	Q9NZJ7	MTCH1_HUMAN	mitochondrial carrier homolog 1	334	Helical; (Potential).				activation of caspase activity|neuronal ion channel clustering|positive regulation of apoptosis|regulation of signal transduction|transport	integral to membrane|mitochondrial inner membrane	protein binding				0						TCACAGCCATGAGGTCGCCAA	0.622		NA											10	52					0	0	0	0
PTK7	5754	broad.mit.edu	37	6	43098331	43098331	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:43098331C>T	uc003oub.1	+	5	942	c.744C>T	c.(742-744)TTC>TTT	p.F248F	PTK7_uc003ouc.1_Silent_p.F248F|PTK7_uc003oud.1_Silent_p.F248F|PTK7_uc003oue.1_Silent_p.F248F|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.F256F|PTK7_uc010jyj.1_5'Flank|PTK7_uc003oua.2_Silent_p.F248F	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	248	Ig-like C2-type 3.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			ATTGCCAGTTCTCAGCCCAGC	0.582		NA											3	32					0	0	0	0
MUT	4594	broad.mit.edu	37	6	49415427	49415427	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:49415427C>T	uc003ozg.3	-	8	1771	c.1516G>A	c.(1516-1518)GAT>AAT	p.D506N		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	506					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAAGTATTATCAATTGCCAGA	0.269		NA											13	70					0	0	0	0
C6orf165	154313	broad.mit.edu	37	6	88144769	88144769	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:88144769C>T	uc003plv.2	+	11	1584	c.1492C>T	c.(1492-1494)CAG>TAG	p.Q498*	SLC35A1_uc003plx.2_5'Flank|C6orf165_uc003plw.2_Nonsense_Mutation_p.Q310*|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Nonsense_Mutation_p.Q498*	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	498										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TCCATATTCTCAGGTAAGCAG	0.284		NA											6	56					0	0	0	0
MDN1	23195	broad.mit.edu	37	6	90472197	90472197	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:90472197C>G	uc003pnn.1	-	16	2313	c.2197G>C	c.(2197-2199)GAG>CAG	p.E733Q	MDN1_uc003pno.1_Missense_Mutation_p.E151Q	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	733					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAGAGTTCCTCAAATGCCTCC	0.423		NA											4	75					0	0	0	0
FBXL4	26235	broad.mit.edu	37	6	99347183	99347183	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:99347183G>A	uc003ppf.1	-	6	1636	c.1278C>T	c.(1276-1278)TGC>TGT	p.C426C	FBXL4_uc003ppg.1_Silent_p.C426C|FBXL4_uc003pph.1_Silent_p.C28C|FBXL4_uc010kcp.2_Silent_p.C28C	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	426					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		GTTTAAGGCTGCATAACTTGG	0.378		NA											14	78					0	0	0	0
AIM1	202	broad.mit.edu	37	6	106999740	106999740	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:106999740G>A	uc003prh.2	+	12	4589	c.4102G>A	c.(4102-4104)GAA>AAA	p.E1368K	AIM1_uc003pri.2_Missense_Mutation_p.E172K	NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1368	Beta/gamma crystallin 'Greek key' 8.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		GGTAGCCTATGAAAATCCTGA	0.338		NA											25	159					0	0	0	0
FAM26D	221301	broad.mit.edu	37	6	116879267	116879267	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:116879267C>G	uc003pxa.2	+	4	708	c.409C>G	c.(409-411)CTT>GTT	p.L137V	FAM26D_uc003pwz.2_Missense_Mutation_p.L94V|FAM26D_uc010ked.2_Missense_Mutation_p.L136V	NM_153036	NP_694581	Q5JW98	FA26D_HUMAN	hypothetical protein LOC221301	280						integral to membrane					0		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0458)|OV - Ovarian serous cystadenocarcinoma(136;0.0694)|Epithelial(106;0.222)		AGTACCCACTCTTTTATGCAT	0.423		NA											16	113					0	0	0	0
ZUFSP	221302	broad.mit.edu	37	6	116988128	116988128	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:116988128C>T	uc003pxf.1	-	2	474	c.228G>A	c.(226-228)AAG>AAA	p.K76K	ZUFSP_uc010kef.1_Intron	NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	76						intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		TGTTGTCTTTCTTGTTATCTG	0.338		NA											15	83					0	0	0	0
EYA4	2070	broad.mit.edu	37	6	133783787	133783787	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:133783787G>A	uc003qec.3	+	9	1067	c.609G>A	c.(607-609)AAG>AAA	p.K203K	EYA4_uc011ecq.1_Silent_p.K149K|EYA4_uc011ecr.1_Silent_p.K149K|EYA4_uc003qed.3_Silent_p.K203K|EYA4_uc003qee.3_Silent_p.K180K|EYA4_uc011ecs.1_Silent_p.K203K|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	203					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CAGCCATCAAGACAGAGAGTG	0.438		NA											9	56					0	0	0	0
IFNGR1	3459	broad.mit.edu	37	6	137527279	137527279	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:137527279G>A	uc003qho.2	-	3	470	c.367C>T	c.(367-369)CGA>TGA	p.R123*	IFNGR1_uc011edm.1_Nonsense_Mutation_p.R95*|IFNGR1_uc011edn.1_Nonsense_Mutation_p.R113*	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	123	Extracellular (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	TCACCATCTCGGCATACAGCA	0.348		NA											14	76					0	0	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138202334	138202334	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr6:138202334G>A	uc003qhr.2	+	9	2317	c.2251G>A	c.(2251-2253)GAG>AAG	p.E751K	TNFAIP3_uc003qhs.2_Missense_Mutation_p.E751K	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	751	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)|p.E751K(1)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CCACCGGGGTGAGCCTGCCCC	0.647		NA	D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								5	64					0	0	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18066763	18066763	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:18066763C>T	uc003stz.2	-	1	724	c.643G>A	c.(643-645)GTG>ATG	p.V215M		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	215	Binding of phosphoribosylpyrophosphate (Potential).				nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					AGGATAGCCACACGATCATTC	0.453		NA											23	99					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21781778	21781778	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:21781778C>T	uc003svc.2	+	50	8200	c.8169C>T	c.(8167-8169)GTC>GTT	p.V2723V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2723	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TATCAAACGTCTTCCAGGTAC	0.294		NA							Kartagener_syndrome				13	45					0	0	0	0
EPDR1	54749	broad.mit.edu	37	7	37989863	37989863	+	Silent	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:37989863C>A	uc003tfp.2	+	3	919	c.900C>A	c.(898-900)ACC>ACA	p.T300T	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Silent_p.T119T	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	180					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						AAACCTTTACCATAAACTACA	0.428		NA											4	41					0.00116845	0.00119389	1	0
VPS41	27072	broad.mit.edu	37	7	38796440	38796440	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:38796440C>G	uc003tgy.2	-	19	1719	c.1693G>C	c.(1693-1695)GAG>CAG	p.E565Q	VPS41_uc003tgz.2_Missense_Mutation_p.E540Q|VPS41_uc010kxn.2_Missense_Mutation_p.E476Q	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	565					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CACATTACCTCTGAATCAAAA	0.269		NA											3	20					0	0	0	0
ZNF713	349075	broad.mit.edu	37	7	56007242	56007242	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:56007242G>A	uc003trc.1	+	4	874	c.836G>A	c.(835-837)GGA>GAA	p.G279E	ZNF713_uc003tra.1_Missense_Mutation_p.G292E|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	279	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GATGAATGTGGAAAAAGATTC	0.458		NA											8	52					0	0	0	0
PTPN12	5782	broad.mit.edu	37	7	77256781	77256781	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:77256781C>T	uc003ugh.2	+	13	1876	c.1785C>T	c.(1783-1785)CTC>CTT	p.L595L	PTPN12_uc011kgp.1_Silent_p.L476L|PTPN12_uc011kgq.1_Silent_p.L465L|PTPN12_uc010lds.2_Silent_p.L327L	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	595						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						GAACACCCCTCAGTTTTACTA	0.403		NA											19	160					0	0	0	0
STEAP2	261729	broad.mit.edu	37	7	89856767	89856767	+	Missense_Mutation	SNP	G	G	C	rs151250725		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:89856767G>C	uc003ujz.2	+	3	1368	c.975G>C	c.(973-975)ATG>ATC	p.M325I	STEAP2_uc003ujy.2_Missense_Mutation_p.M367I|STEAP2_uc010len.2_Missense_Mutation_p.M325I|STEAP2_uc003uka.2_Missense_Mutation_p.M325I|STEAP2_uc003ukb.2_Missense_Mutation_p.M325I|STEAP2_uc003ukc.2_Missense_Mutation_p.M325I|STEAP2_uc003ukd.2_Missense_Mutation_p.M325I	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	325	Ferric oxidoreductase.|Helical; (Potential).				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					GCTTACCGATGAGAAGGTCAG	0.383		NA											10	40					0	0	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92838091	92838091	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:92838091C>T	uc003umm.2	-	4	837	c.814G>A	c.(814-816)GCT>ACT	p.A272T	HEPACAM2_uc003uml.2_Missense_Mutation_p.A260T|HEPACAM2_uc010lff.2_Missense_Mutation_p.A260T|HEPACAM2_uc011khy.1_Missense_Mutation_p.A295T	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	272	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TGAGAATCAGCAGAACAATCA	0.433		NA											14	78					0	0	0	0
ZAN	7455	broad.mit.edu	37	7	100344231	100344231	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:100344231G>A	uc003uwj.2	+	8	1002	c.837G>A	c.(835-837)GTG>GTA	p.V279V	ZAN_uc003uwk.2_Silent_p.V279V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	279	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGAGCCCCGTGAGCCTGTCCT	0.572		NA											9	95					0	0	0	0
C7orf52	375607	broad.mit.edu	37	7	100816658	100816658	+	Silent	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:100816658C>A	uc003uxy.1	-	3	695	c.456G>T	c.(454-456)CCG>CCT	p.P152P	C7orf52_uc003uxz.1_Silent_p.P152P	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	152	N-acetyltransferase.						N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					CCTTGACCCCCGGGTGCTGTC	0.687		NA											14	42					7.93e-07	8.34e-07	1	0
CUX1	1523	broad.mit.edu	37	7	101844841	101844841	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:101844841C>G	uc003uyx.3	+	18	2302	c.2264C>G	c.(2263-2265)TCC>TGC	p.S755C	CUX1_uc003uys.3_Missense_Mutation_p.S766C|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	755					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CCCACCGTGTCCAGCTACCCA	0.647		NA											21	110					0	0	0	0
NRCAM	4897	broad.mit.edu	37	7	107822288	107822288	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:107822288C>T	uc003vfb.2	-	24	3095	c.2624G>A	c.(2623-2625)CGA>CAA	p.R875Q	NRCAM_uc003vfc.2_Missense_Mutation_p.R859Q|NRCAM_uc011kmk.1_Missense_Mutation_p.R870Q|NRCAM_uc003vfd.2_Missense_Mutation_p.R851Q|NRCAM_uc003vfe.2_Missense_Mutation_p.R851Q	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	875	Fibronectin type-III 3.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TAGGTGTCCTCGGATGCTTTT	0.527		NA											11	38					0	0	0	0
EXOC4	60412	broad.mit.edu	37	7	133041328	133041328	+	Splice_Site	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:133041328G>A	uc003vrk.2	+	6	1042	c.1007_splice	c.e6+1	p.R336_splice	EXOC4_uc011kpo.1_Splice_Site_p.R235_splice|EXOC4_uc003vri.2_Splice_Site_p.R336_splice|EXOC4_uc003vrj.2_Splice_Site_p.R336_splice	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a						vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				ACCAACCAAGGTAGGTGGGAG	0.448		NA											3	32					0	0	0	0
WEE2	494551	broad.mit.edu	37	7	141422958	141422958	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:141422958C>T	uc003vwn.2	+	6	1311	c.905C>T	c.(904-906)TCT>TTT	p.S302F	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	302	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GCTGCTATATCTGAAAACACT	0.383		NA											20	105					0	0	0	0
SMARCD3	6604	broad.mit.edu	37	7	150936782	150936782	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr7:150936782G>C	uc003wjs.2	-	11	1325	c.1224C>G	c.(1222-1224)TTC>TTG	p.F408L	SMARCD3_uc003wjt.2_Missense_Mutation_p.F395L|SMARCD3_uc003wju.2_Missense_Mutation_p.F395L	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	408					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCTTAGCATGAAGTCCCTCT	0.532		NA											21	98					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	2836257	2836257	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:2836257C>T	uc011kwk.1	-	55	8836	c.8446G>A	c.(8446-8448)GAG>AAG	p.E2816K	CSMD1_uc011kwj.1_Missense_Mutation_p.E2145K|CSMD1_uc010lrg.2_Missense_Mutation_p.E826K	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2816	Extracellular (Potential).|Sushi 20.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCAAAACTCTCAGGGAAGTTC	0.423		NA											3	16					0	0	0	0
RP1L1	94137	broad.mit.edu	37	8	10470341	10470341	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:10470341G>A	uc003wtc.2	-	4	1496	c.1267C>T	c.(1267-1269)CGG>TGG	p.R423W		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	423					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CACCTCTTCCGAGCTGCCACT	0.667		NA											13	38					0	0	0	0
AMAC1L2	83650	broad.mit.edu	37	8	11188898	11188898	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:11188898C>T	uc003wtp.1	+	1	404	c.283C>T	c.(283-285)CTG>TTG	p.L95L		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	95	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		CGACCCCCTTCTGGGACCTCC	0.602		NA											35	237					0	0	0	0
SLC7A2	6542	broad.mit.edu	37	8	17419529	17419529	+	Silent	SNP	C	C	T	rs139462829		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:17419529C>T	uc011kyc.1	+	10	1750	c.1581C>T	c.(1579-1581)CTC>CTT	p.L527L	SLC7A2_uc011kyd.1_Silent_p.L566L|SLC7A2_uc011kye.1_Silent_p.L567L|SLC7A2_uc011kyf.1_Silent_p.L527L	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	527	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	CCTGGAGCCTCGCTCTCCTCG	0.532		NA											21	70					0	0	0	0
MTUS1	57509	broad.mit.edu	37	8	17613142	17613142	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:17613142C>G	uc003wxv.2	-	2	649	c.175G>C	c.(175-177)GAA>CAA	p.E59Q	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.E59Q|MTUS1_uc010lsz.2_Missense_Mutation_p.E59Q	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	59						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GGGTCAGTTTCATAATCAACC	0.403		NA											28	168					0	0	0	0
DOK2	9046	broad.mit.edu	37	8	21767244	21767244	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:21767244G>A	uc003wzy.1	-	5	910	c.817C>T	c.(817-819)CGG>TGG	p.R273W	DOK2_uc003wzx.1_Missense_Mutation_p.R273W|DOK2_uc003wzz.1_Missense_Mutation_p.R119W|DOK2_uc010lth.1_Missense_Mutation_p.R119W	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	273	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TCATGCGGCCGAGAGTAGGGG	0.682		NA											6	59					0	0	0	0
LOXL2	4017	broad.mit.edu	37	8	23167319	23167319	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:23167319G>A	uc003xdh.1	-	10	2081	c.1742C>T	c.(1741-1743)TCG>TTG	p.S581L	LOXL2_uc010lty.1_Missense_Mutation_p.S120L	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	581	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GGCTGAGGCCGAGAGGCAGTT	0.647		NA											5	25					0	0	0	0
LOXL2	4017	broad.mit.edu	37	8	23174627	23174627	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:23174627C>G	uc003xdh.1	-	9	1810	c.1471G>C	c.(1471-1473)GAG>CAG	p.E491Q	LOXL2_uc010lty.1_Missense_Mutation_p.E30Q	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	491	SRCR 4.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TACCAGGTCTCCTGGAAGAAC	0.388		NA											33	125					0	0	0	0
HTRA4	203100	broad.mit.edu	37	8	38840029	38840029	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:38840029C>T	uc003xmj.2	+	7	1242	c.1127C>T	c.(1126-1128)TCA>TTA	p.S376L		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	376					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			AAGGCGTTTTCAAATAAGAAA	0.423		NA											6	56					0	0	0	0
SFRP1	6422	broad.mit.edu	37	8	41161008	41161008	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:41161008G>C	uc003xnt.2	-	2	896	c.594C>G	c.(592-594)ATC>ATG	p.I198M		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1 precursor	198	NTR.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			GATGTTCAATGATGGCCTCAG	0.527		NA											11	36					0	0	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68131668	68131668	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:68131668C>T	uc003xxo.1	-	30	4726	c.4336G>A	c.(4336-4338)GAG>AAG	p.E1446K	ARFGEF1_uc003xxl.1_Missense_Mutation_p.E900K|ARFGEF1_uc003xxn.1_Missense_Mutation_p.E429K	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1446					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CCTCTTACCTCTGTCTGTTGT	0.308		NA											3	36					0	0	0	0
PREX2	80243	broad.mit.edu	37	8	69058533	69058533	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:69058533C>G	uc003xxv.1	+	34	4204	c.4177C>G	c.(4177-4179)CAA>GAA	p.Q1393E		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1393					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACAACTTCCTCAACGGCTGAA	0.338		NA											8	46					0	0	0	0
KCNB2	9312	broad.mit.edu	37	8	73850115	73850115	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:73850115G>A	uc003xzb.2	+	3	3113	c.2525G>A	c.(2524-2526)AGA>AAA	p.R842K		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	842	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGTGATGGGAGAGACCCTTTA	0.527		NA											10	71					0	0	0	0
ZNF704	619279	broad.mit.edu	37	8	81577163	81577163	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:81577163C>G	uc003yby.1	-	6	1046	c.814G>C	c.(814-816)GAT>CAT	p.D272H		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	272						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CGGCTTGAATCTGGGATGGGG	0.577		NA											19	107					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100147838	100147838	+	Silent	SNP	C	C	T	rs141324814	byFrequency	TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:100147838C>T	uc003yiv.2	+	11	1551	c.1440C>T	c.(1438-1440)TTC>TTT	p.F480F	VPS13B_uc003yiw.2_Silent_p.F480F|VPS13B_uc003yit.2_Silent_p.F480F|VPS13B_uc003yiu.1_Silent_p.F480F|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	480					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCTGTTTCTTCATTTGTGGTG	0.333		NA											6	39					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100523503	100523503	+	Nonsense_Mutation	SNP	G	G	T	rs120074151		TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:100523503G>T	uc003yiv.2	+	29	4582	c.4471G>T	c.(4471-4473)GAA>TAA	p.E1491*	VPS13B_uc003yiw.2_Nonsense_Mutation_p.E1466*|VPS13B_uc003yix.1_Nonsense_Mutation_p.E961*	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1491					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTTTCTTCATGAAATTCTTCT	0.333		NA											12	62					0.000978159	0.00100257	1	0
NCALD	83988	broad.mit.edu	37	8	102731491	102731491	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:102731491C>G	uc003yke.2	-	2	736	c.367G>C	c.(367-369)GAG>CAG	p.E123Q	NCALD_uc003ykf.2_Missense_Mutation_p.E123Q|NCALD_uc003ykg.2_Missense_Mutation_p.E123Q|NCALD_uc003ykh.2_Missense_Mutation_p.E123Q|NCALD_uc003yki.2_Missense_Mutation_p.E123Q|NCALD_uc003ykj.2_Missense_Mutation_p.E123Q|NCALD_uc003ykk.2_Missense_Mutation_p.E123Q|NCALD_uc003ykl.2_Missense_Mutation_p.E123Q	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	123	EF-hand 3.			E -> V (in Ref. 2; CAB66547).	synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			TGCACGATCTCTAGCATCTCT	0.463		NA											17	100					0	0	0	0
ABRA	137735	broad.mit.edu	37	8	107782097	107782097	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:107782097C>G	uc003ymm.3	-	1	376	c.322G>C	c.(322-324)GAG>CAG	p.E108Q		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	108					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			TTGGACACCTCTTTCTTTTTG	0.552		NA											6	137					0	0	0	0
NUDCD1	84955	broad.mit.edu	37	8	110293297	110293297	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:110293297G>A	uc003ynb.3	-	6	1039	c.928C>T	c.(928-930)CAC>TAC	p.H310Y	NUDCD1_uc003yna.2_Missense_Mutation_p.H281Y|NUDCD1_uc010mcl.2_Missense_Mutation_p.H223Y|NUDCD1_uc010mcm.1_Missense_Mutation_p.H223Y	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	310	CS.									ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			ATGTTGATGTGATCAGGCAAA	0.363		NA											10	45					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110497290	110497290	+	Silent	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:110497290G>C	uc003yne.2	+	58	9698	c.9594G>C	c.(9592-9594)GTG>GTC	p.V3198V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3198	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAGAGATTGTGATAACAACCA	0.294		NA								HNSCC(38;0.096)			9	48					0	0	0	0
RAD21	5885	broad.mit.edu	37	8	117874120	117874120	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:117874120C>A	uc003yod.2	-	4	622	c.334G>T	c.(334-336)GAA>TAA	p.E112*		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	112					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TGAAATTCTTCAGGTAAAGTA	0.378		NA											29	144					8.58e-18	9.21e-18	1	0
SLC30A8	169026	broad.mit.edu	37	8	118183390	118183390	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:118183390C>T	uc003yoh.2	+	7	1177	c.947C>T	c.(946-948)TCA>TTA	p.S316L	SLC30A8_uc010mcz.2_Missense_Mutation_p.S267L|SLC30A8_uc011lia.1_Missense_Mutation_p.S267L|SLC30A8_uc003yog.2_Missense_Mutation_p.S267L	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	316	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			GTAATTCTCTCAGCTCATGTT	0.423		NA											15	85					0	0	0	0
COLEC10	10584	broad.mit.edu	37	8	120118062	120118062	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:120118062G>A	uc003yoo.2	+	6	563	c.466G>A	c.(466-468)GAA>AAA	p.E156K		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	156	C-type lectin.					collagen|cytoplasm	mannose binding			ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			TAGGGAAACTGAAGAGAAATT	0.428		NA											4	26					0	0	0	0
ZHX2	22882	broad.mit.edu	37	8	123965799	123965799	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:123965799G>A	uc003ypk.1	+	3	2616	c.2049G>A	c.(2047-2049)CTG>CTA	p.L683L		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	683	Homeobox 4.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GATGCTTGCTGAAAACGGGAA	0.557		NA											5	51					0	0	0	0
ZHX2	22882	broad.mit.edu	37	8	123965807	123965807	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:123965807G>C	uc003ypk.1	+	3	2624	c.2057G>C	c.(2056-2058)GGA>GCA	p.G686A		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	686	Homeobox 4.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CTGAAAACGGGAACCGTGAAG	0.557		NA											5	52					0	0	0	0
EPPK1	83481	broad.mit.edu	37	8	144941998	144941998	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:144941998G>A	uc003zaa.1	-	1	5437	c.5424C>T	c.(5422-5424)GAC>GAT	p.D1808D		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1808						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCGCTTCCTGTCCTCTGTGA	0.527		NA											16	71					0	0	0	0
SPATC1	375686	broad.mit.edu	37	8	145096263	145096263	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr8:145096263G>C	uc011lkw.1	+	4	1539	c.1437G>C	c.(1435-1437)AAG>AAC	p.K479N	SPATC1_uc011lkx.1_Intron	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	479										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCCAGAGAAGATCATCCAGG	0.632		NA											6	25					0	0	0	0
UHRF2	115426	broad.mit.edu	37	9	6506134	6506134	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:6506134G>A	uc003zjy.2	+	16	2704	c.2364G>A	c.(2362-2364)CAG>CAA	p.Q788Q	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zkb.2_RNA	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	788					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		AGATTCTGCAGACTCTACTTG	0.463		NA											5	100					0	0	0	0
MTAP	4507	broad.mit.edu	37	9	21854777	21854777	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:21854777C>T	uc003zph.2	+	6	711	c.598C>T	c.(598-600)CCA>TCA	p.P200S	MTAP_uc003zpi.1_Intron|MTAP_uc010mit.2_RNA|MTAP_uc011lnk.1_Missense_Mutation_p.P217S|MTAP_uc011lnl.1_Missense_Mutation_p.P133S	NM_002451	NP_002442	Q13126	MTAP_HUMAN	5'-methylthioadenosine phosphorylase	200					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	GACCACAGTTCCAGAGGTGGT	0.537		NA											9	58					0	0	0	0
GBA2	57704	broad.mit.edu	37	9	35739738	35739738	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35739738C>G	uc003zxw.2	-	9	1993	c.1469G>C	c.(1468-1470)GGA>GCA	p.G490A	GBA2_uc003zxx.1_5'Flank|GBA2_uc011lpb.1_Missense_Mutation_p.G490A|GBA2_uc011lpc.1_Missense_Mutation_p.G490A|GBA2_uc011lpd.1_Missense_Mutation_p.G496A|GBA2_uc003zxy.1_Missense_Mutation_p.G203A	NM_020944	NP_065995	Q9HCG7	GBA2_HUMAN	bile acid beta-glucosidase	490	Extracellular (Potential).				bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			ovary(3)|skin(1)	4	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CACTGTGCCTCCATCAGCCAG	0.532		NA											7	41					0	0	0	0
GBA2	57704	broad.mit.edu	37	9	35741858	35741858	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35741858C>G	uc003zxw.2	-	4	1121	c.597G>C	c.(595-597)CAG>CAC	p.Q199H	GBA2_uc011lpb.1_Missense_Mutation_p.Q199H|GBA2_uc011lpc.1_Missense_Mutation_p.Q199H|GBA2_uc011lpd.1_Missense_Mutation_p.Q205H|GBA2_uc003zxy.1_5'UTR	NM_020944	NP_065995	Q9HCG7	GBA2_HUMAN	bile acid beta-glucosidase	199	Extracellular (Potential).				bile acid metabolic process|glucosylceramide catabolic process|O-glycoside catabolic process	integral to membrane|microsome|plasma membrane|smooth endoplasmic reticulum	beta-glucosidase activity|glucosylceramidase activity			ovary(3)|skin(1)	4	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGTACACAGTCTGCCCTTCCC	0.567		NA											3	38					0	0	0	0
NPR2	4882	broad.mit.edu	37	9	35806507	35806507	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35806507G>A	uc003zyd.2	+	16	2491	c.2491G>A	c.(2491-2493)GAA>AAA	p.E831K	NPR2_uc010mlb.2_Missense_Mutation_p.E807K	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	831	Cytoplasmic (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ACGCAAGGCTGAAGCTCTGCT	0.517		NA											17	78					0	0	0	0
OR13J1	392309	broad.mit.edu	37	9	35870019	35870019	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:35870019C>A	uc011lph.1	-	1	380	c.380G>T	c.(379-381)TGC>TTC	p.C127F		NM_001004487	NP_001004487	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GAGTGGCTGGCAGATGGCCAG	0.617		NA											10	42					7.48e-07	7.87e-07	1	0
CLTA	1211	broad.mit.edu	37	9	36211652	36211652	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:36211652G>A	uc003zzc.2	+	7	790	c.628G>A	c.(628-630)GAG>AAG	p.E210K	CLTA_uc003zzd.2_Missense_Mutation_p.E198K|CLTA_uc003zze.2_Missense_Mutation_p.E180K|CLTA_uc011lpk.1_Missense_Mutation_p.E192K|CLTA_uc003zzf.1_Intron	NM_007096	NP_009027	P09496	CLCA_HUMAN	clathrin, light polypeptide A isoform b	210					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol	structural molecule activity			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)			CCCAGGCACTGAGTGGGAACG	0.527		NA											14	115					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77354768	77354768	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:77354768G>A	uc004ajl.1	-	34	5596	c.5358C>T	c.(5356-5358)GTC>GTT	p.V1786V	TRPM6_uc004ajk.1_Silent_p.V1781V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Silent_p.V737V|TRPM6_uc010mpd.1_Silent_p.V619V|TRPM6_uc010mpe.1_Silent_p.V333V|TRPM6_uc004ajj.1_Silent_p.V742V	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1786	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						ACCAAGTGCTGACGACTCTCA	0.512		NA											20	109					0	0	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88193845	88193845	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:88193845C>T	uc011ltd.1	-	23	3365	c.3332G>A	c.(3331-3333)GGA>GAA	p.G1111E	AGTPBP1_uc004aod.3_Missense_Mutation_p.G737E|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.G1071E|AGTPBP1_uc011lte.1_Missense_Mutation_p.G1123E	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1111					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						CTTGTATTTTCCCTGATCACA	0.323		NA											18	126					0	0	0	0
C9orf3	84909	broad.mit.edu	37	9	97844977	97844977	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:97844977G>T	uc004ava.2	+	15	2575	c.2440G>T	c.(2440-2442)GTG>TTG	p.V814L	C9orf3_uc004auy.2_Missense_Mutation_p.V715L|C9orf3_uc004avc.2_Intron|C9orf3_uc011luj.1_Missense_Mutation_p.V176L|C9orf3_uc011luk.1_Missense_Mutation_p.V155L|C9orf3_uc004avd.2_Missense_Mutation_p.V176L|MIR23B_hsa-mir-23b|MI0000439_5'Flank|uc004avg.3_5'Flank|MIR27B_hsa-mir-27b|MI0000440_5'Flank	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	814					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AGCCCAGGTGGTGGCCGAAAT	0.517		NA											13	50					4.38e-07	4.62e-07	1	0
PTCH1	5727	broad.mit.edu	37	9	98242295	98242295	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:98242295C>G	uc004avk.3	-	7	1211	c.1023G>C	c.(1021-1023)TTG>TTC	p.L341F	PTCH1_uc010mro.2_Missense_Mutation_p.L190F|PTCH1_uc010mrp.2_Missense_Mutation_p.L190F|PTCH1_uc010mrq.2_Missense_Mutation_p.L190F|PTCH1_uc004avl.3_Missense_Mutation_p.L190F|PTCH1_uc010mrr.2_Missense_Mutation_p.L275F|PTCH1_uc004avm.3_Missense_Mutation_p.L340F|PTCH1_uc010mrs.1_Missense_Mutation_p.L61F	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	341	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.L341F(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CACCCACAATCAACTCCTCCT	0.458		NA							Basal_Cell_Nevus_syndrome				30	110					0	0	0	0
FOXE1	2304	broad.mit.edu	37	9	100616544	100616544	+	Silent	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:100616544C>G	uc004axu.2	+	1	1008	c.348C>G	c.(346-348)CGC>CGG	p.R116R		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	116	Fork-head.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				AGATCCCGCGCGAGGCCGGCC	0.637		NA											8	64					0	0	0	0
TRIM14	9830	broad.mit.edu	37	9	100872212	100872212	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:100872212C>T	uc004ayd.2	-	2	280	c.262G>A	c.(262-264)GAC>AAC	p.D88N	TRIM14_uc004ayf.1_5'UTR|TRIM14_uc004ayg.1_Missense_Mutation_p.D88N|TRIM14_uc004ayh.1_Missense_Mutation_p.D88N|TRIM14_uc004ayi.1_Missense_Mutation_p.D88N|TRIM14_uc004ayj.1_5'UTR	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	88	Potential.					cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GTTATGTTGTCAATGTGCTGC	0.448		NA											25	207					0	0	0	0
ERP44	23071	broad.mit.edu	37	9	102784444	102784444	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:102784444C>T	uc004bam.2	-	5	559	c.351G>A	c.(349-351)ATG>ATA	p.M117I	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Missense_Mutation_p.M117I	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	117	Thioredoxin.				cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0						TCTTCATCATCATCCCATTAC	0.393		NA											12	115					0	0	0	0
AKNA	80709	broad.mit.edu	37	9	117120255	117120255	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:117120255G>C	uc004biq.3	-	11	2820	c.2685C>G	c.(2683-2685)ATC>ATG	p.I895M	AKNA_uc004bin.3_Missense_Mutation_p.I142M|AKNA_uc004bio.3_Missense_Mutation_p.I355M|AKNA_uc004bip.3_Missense_Mutation_p.I814M|AKNA_uc004bir.3_Missense_Mutation_p.I895M|AKNA_uc004bis.3_Missense_Mutation_p.I895M|AKNA_uc010mve.2_Missense_Mutation_p.I776M	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	895					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						GGCGCTCAGAGATGCCGCTTC	0.642		NA											10	65					0	0	0	0
OR1L3	26735	broad.mit.edu	37	9	125438029	125438029	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:125438029G>A	uc011lzb.1	+	1	621	c.621G>A	c.(619-621)GTG>GTA	p.V207V		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGGCCTCTGTGATGGCTCCAT	0.453		NA											29	120					0	0	0	0
RABGAP1	23637	broad.mit.edu	37	9	125865491	125865491	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:125865491G>A	uc011lzh.1	+	26	3343	c.3209G>A	c.(3208-3210)TGA>TAA	p.*1070*	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc011lzj.1_Silent_p.*409*	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	1070					cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						GAGACTTGCTGAGAGCAGCTG	0.522		NA									OREG0019466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	73					0	0	0	0
HSPA5	3309	broad.mit.edu	37	9	127999008	127999008	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:127999008C>T	uc004bpn.2	-	8	2084	c.1828G>A	c.(1828-1830)GAT>AAT	p.D610N		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	610					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	ATGTCAGCATCTTGGTGGCTT	0.423		NA								Prostate(1;0.17)			16	127					0	0	0	0
HSPA5	3309	broad.mit.edu	37	9	128001040	128001040	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:128001040C>T	uc004bpn.2	-	6	1319	c.1063G>A	c.(1063-1065)GAT>AAT	p.D355N		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	355					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TCATCAATATCAGACTTCTTC	0.418		NA								Prostate(1;0.17)			15	57					0	0	0	0
HSPA5	3309	broad.mit.edu	37	9	128001050	128001050	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:128001050C>T	uc004bpn.2	-	6	1309	c.1053G>A	c.(1051-1053)TTG>TTA	p.L351L		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	351					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	CAGACTTCTTCAAATCAGAAT	0.393		NA								Prostate(1;0.17)			16	51					0	0	0	0
SPTAN1	6709	broad.mit.edu	37	9	131388879	131388879	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:131388879G>C	uc004bvl.3	+	48	6587	c.6474G>C	c.(6472-6474)AAG>AAC	p.K2158N	SPTAN1_uc004bvm.3_Missense_Mutation_p.K2163N|SPTAN1_uc004bvn.3_Missense_Mutation_p.K2138N|SPTAN1_uc010mye.1_5'UTR|SPTAN1_uc010myf.1_5'UTR	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2158	Spectrin 22.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCCAGATCAAGAGCTTCCGCG	0.597		NA											9	32					0	0	0	0
NCS1	23413	broad.mit.edu	37	9	132984969	132984969	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:132984969C>G	uc004bzi.2	+	5	434	c.348C>G	c.(346-348)ATC>ATG	p.I116M	NCS1_uc010myz.1_Missense_Mutation_p.I98M	NM_014286	NP_055101	P62166	NCS1_HUMAN	frequenin homolog isoform 1	116	EF-hand 3.|2.				negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding				0						ATGGCTACATCACCAGGAATG	0.562		NA											11	57					0	0	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134473643	134473643	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:134473643G>A	uc004cbc.2	-	13	2128	c.1998C>T	c.(1996-1998)GAC>GAT	p.D666D	RAPGEF1_uc004cbb.2_Silent_p.D684D|RAPGEF1_uc010mzm.2_RNA|RAPGEF1_uc010mzn.2_Silent_p.D841D|RAPGEF1_uc004cbd.2_Silent_p.D671D|RAPGEF1_uc010mzs.1_Silent_p.D198D|RAPGEF1_uc010mzl.1_Silent_p.D164D|RAPGEF1_uc010mzo.1_3'UTR|RAPGEF1_uc010mzp.1_Silent_p.D143D|RAPGEF1_uc010mzq.1_Silent_p.D250D|RAPGEF1_uc010mzr.1_Silent_p.D251D	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	666					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GGGACAGCTCGTCCACTTCCT	0.592		NA											8	22					0	0	0	0
NTNG2	84628	broad.mit.edu	37	9	135073644	135073644	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:135073644G>A	uc004cbh.2	+	3	1281	c.505G>A	c.(505-507)GAG>AAG	p.E169K		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	169	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GTTCTACGCCGAGGACTGCAT	0.672		NA											6	19					0	0	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136323096	136323096	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:136323096G>A	uc004cdv.3	+	28	4401	c.3957G>A	c.(3955-3957)ACG>ACA	p.T1319T	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Silent_p.T1263T|ADAMTS13_uc004cdu.1_Silent_p.T1232T|ADAMTS13_uc004cdw.3_Silent_p.T1263T|ADAMTS13_uc004cdx.3_Silent_p.T1232T|ADAMTS13_uc004cdz.3_Silent_p.T989T|ADAMTS13_uc004cea.1_3'UTR|ADAMTS13_uc004ceb.3_Silent_p.T115T|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1319	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GTCCAGCCACGAGTAATGCAG	0.607		NA											4	69					0	0	0	0
VAV2	7410	broad.mit.edu	37	9	136629201	136629201	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:136629201C>T	uc004ces.2	-	30	2666	c.2620G>A	c.(2620-2622)GAG>AAG	p.E874K	VAV2_uc004cer.2_Missense_Mutation_p.E835K	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	874	SH3 2.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		ATGCCCTCCTCTTCTACGTAC	0.433		NA											5	42					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139391123	139391123	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:139391123G>A	uc004chz.2	-	34	7068	c.7068C>T	c.(7066-7068)GCC>GCT	p.A2356A		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2356	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACAGGGCGCTGGCAGCAAGGC	0.672		NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			10	62					0	0	0	0
FAM166A	401565	broad.mit.edu	37	9	140139845	140139845	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:140139845C>T	uc004cmi.1	-	3	491	c.436G>A	c.(436-438)GAC>AAC	p.D146N		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	146										ovary(1)	1						TCTCTGGAGTCTCCCTTCCTG	0.652		NA											7	74					0	0	0	0
COBRA1	25920	broad.mit.edu	37	9	140150496	140150496	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr9:140150496C>G	uc004cmm.3	+	2	443	c.240C>G	c.(238-240)ATC>ATG	p.I80M		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	80					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		TGTCAGCCATCGCTTCGGAGG	0.642		NA											14	81					0	0	0	0
ARSE	415	broad.mit.edu	37	X	2878422	2878422	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:2878422G>A	uc004crc.3	-	2	270	c.20C>T	c.(19-21)TCT>TTT	p.S7F	ARSE_uc011mhi.1_Missense_Mutation_p.S7F|ARSE_uc011mhh.1_5'UTR	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	7					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATCTTACCAAGAATGGTGCAG	0.244		NA											11	21					0	0	0	0
PHKA2	5256	broad.mit.edu	37	X	18956826	18956826	+	Silent	SNP	G	G	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:18956826G>T	uc004cyv.3	-	10	1390	c.960C>A	c.(958-960)CTC>CTA	p.L320L		NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	320					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TGTTTTCGAAGAGCTTGAGTT	0.383		NA											15	35					1.03e-11	1.1e-11	1	0
DDX3X	1654	broad.mit.edu	37	X	41206168	41206168	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:41206168G>C	uc004dfe.2	+	15	2527	c.1672G>C	c.(1672-1674)GAT>CAT	p.D558H	DDX3X_uc004dff.2_Missense_Mutation_p.D558H|DDX3X_uc011mkq.1_Missense_Mutation_p.D542H|DDX3X_uc011mkr.1_Missense_Mutation_p.D428H|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	558	Helicase C-terminal.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						GGATTTGTTGGATCTTCTTGT	0.393		NA								HNSCC(61;0.18)			15	24					0	0	0	0
DDX3X	1654	broad.mit.edu	37	X	41206210	41206210	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:41206210G>C	uc004dfe.2	+	15	2569	c.1714G>C	c.(1714-1716)GAA>CAA	p.E572Q	DDX3X_uc004dff.2_Missense_Mutation_p.E572Q|DDX3X_uc011mkq.1_Missense_Mutation_p.E556Q|DDX3X_uc011mkr.1_Missense_Mutation_p.E442Q|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	572	Helicase C-terminal.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						GTCTTGGTTAGAAAACATGGC	0.403		NA								HNSCC(61;0.18)			16	22					0	0	0	0
NONO	4841	broad.mit.edu	37	X	70514197	70514197	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:70514197C>T	uc004dzo.2	+	6	1179	c.469C>T	c.(469-471)CAG>TAG	p.Q157*	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Nonsense_Mutation_p.Q157*|NONO_uc004dzp.2_Nonsense_Mutation_p.Q157*|NONO_uc011mpv.1_Nonsense_Mutation_p.Q68*|NONO_uc004dzq.2_Nonsense_Mutation_p.Q26*	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	157	RRM 2.|DBHS.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					AAACCTTCCTCAGTATGTGTC	0.517		NA	T	TFE3	papillary renal cancer								16	41					0	0	0	0
BRWD3	254065	broad.mit.edu	37	X	79980560	79980560	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:79980560C>T	uc004edt.2	-	15	1656	c.1393G>A	c.(1393-1395)GAT>AAT	p.D465N	BRWD3_uc004edo.2_Missense_Mutation_p.D61N|BRWD3_uc004edp.2_Missense_Mutation_p.D294N|BRWD3_uc004edq.2_Missense_Mutation_p.D61N|BRWD3_uc010nmj.1_Missense_Mutation_p.D61N|BRWD3_uc004edr.2_Missense_Mutation_p.D135N|BRWD3_uc004eds.2_Missense_Mutation_p.D61N|BRWD3_uc004edu.2_Missense_Mutation_p.D135N|BRWD3_uc004edv.2_Missense_Mutation_p.D61N|BRWD3_uc004edw.2_Missense_Mutation_p.D61N|BRWD3_uc004edx.2_Missense_Mutation_p.D61N|BRWD3_uc004edy.2_Missense_Mutation_p.D61N|BRWD3_uc004edz.2_Missense_Mutation_p.D135N|BRWD3_uc004eea.2_Missense_Mutation_p.D135N|BRWD3_uc004eeb.2_Missense_Mutation_p.D61N	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	465	WD 8.									ovary(4)	4						ACTTCATCATCATGTCCCTAT	0.373		NA											11	21					0	0	0	0
BRWD3	254065	broad.mit.edu	37	X	79989634	79989634	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:79989634C>T	uc004edt.2	-	11	1332	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.E186K|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_Missense_Mutation_p.E27K|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_Missense_Mutation_p.E27K|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_Missense_Mutation_p.E27K|BRWD3_uc004eea.2_Missense_Mutation_p.E27K|BRWD3_uc004eeb.2_5'UTR	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	357										ovary(4)	4						GACTCTAATTCAGCAATTTTC	0.338		NA											20	46					0	0	0	0
KLHL4	56062	broad.mit.edu	37	X	86890739	86890739	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:86890739C>T	uc004efb.2	+	9	2071	c.1889C>T	c.(1888-1890)TCC>TTC	p.S630F	KLHL4_uc004efa.2_Missense_Mutation_p.S630F	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	630	Kelch 5.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCCCCTGCTTCCAACCATTGC	0.403		NA											12	27					0	0	0	0
BTK	695	broad.mit.edu	37	X	100604914	100604914	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:100604914G>A	uc004ehg.2	-	19	2132	c.1939C>T	c.(1939-1941)CTT>TTT	p.L647F	TIMM8A_uc004ehd.2_5'Flank|TIMM8A_uc011mri.1_5'Flank|BTK_uc004ehf.2_Missense_Mutation_p.L147F|BTK_uc010nnh.2_RNA|BTK_uc010nni.2_RNA|BTK_uc004ehe.2_RNA|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_RNA|BTK_uc010nnl.2_Missense_Mutation_p.L123F|BTK_uc010nnm.2_Missense_Mutation_p.L206F|BTK_uc010nnn.2_Missense_Mutation_p.L471F|BTK_uc010nno.2_Missense_Mutation_p.L681F	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	647	Protein kinase.		L -> P (in XLA).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TTGCTCAGAAGAATTTTGAAA	0.393		NA							Agammaglobulinemia_X-linked				32	80					0	0	0	0
RNF113A	7737	broad.mit.edu	37	X	119005174	119005174	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005174C>T	uc004esb.2	-	1	618	c.403G>A	c.(403-405)GAG>AAG	p.E135K	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	135							nucleic acid binding|zinc ion binding			breast(2)	2						TGGCTGCGCTCAAAGATGGCT	0.527		NA											18	253					0	0	0	0
RNF113A	7737	broad.mit.edu	37	X	119005250	119005250	+	Silent	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005250C>T	uc004esb.2	-	1	542	c.327G>A	c.(325-327)GTG>GTA	p.V109V	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	109							nucleic acid binding|zinc ion binding			breast(2)	2						CCTCTGGTCCCACGGGTTTCG	0.562		NA											14	181					0	0	0	0
RNF113A	7737	broad.mit.edu	37	X	119005303	119005303	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005303C>T	uc004esb.2	-	1	489	c.274G>A	c.(274-276)GAG>AAG	p.E92K	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	92	Poly-Glu.						nucleic acid binding|zinc ion binding			breast(2)	2						CTCTCGGGCTCATTTTCCTCT	0.547		NA											11	145					0	0	0	0
RNF113A	7737	broad.mit.edu	37	X	119005408	119005408	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:119005408C>T	uc004esb.2	-	1	384	c.169G>A	c.(169-171)GAA>AAA	p.E57K	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	57							nucleic acid binding|zinc ion binding			breast(2)	2						CGCTTCTTTTCCGGTCGAACC	0.602		NA											6	133					0	0	0	0
GRIA3	2892	broad.mit.edu	37	X	122537305	122537305	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:122537305G>A	uc004etq.3	+	10	1521	c.1228G>A	c.(1228-1230)GAT>AAT	p.D410N	GRIA3_uc004etr.3_Missense_Mutation_p.D410N|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.D394N	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	410	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GCCTTTCTCAGATCAGCAAAT	0.443		NA											58	97					0	0	0	0
IGSF1	3547	broad.mit.edu	37	X	130410218	130410218	+	Silent	SNP	G	G	A			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:130410218G>A	uc004ewd.2	-	15	2851	c.2613C>T	c.(2611-2613)TTC>TTT	p.F871F	IGSF1_uc004ewe.3_Silent_p.F865F|IGSF1_uc004ewf.2_Silent_p.F851F	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	871	Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GTTTGGGGTAGAATTCTGAAA	0.473		NA											11	20					0	0	0	0
GABRA3	2556	broad.mit.edu	37	X	151366158	151366158	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chrX:151366158G>C	uc010ntk.1	-	8	1118	c.878C>G	c.(877-879)TCA>TGA	p.S293*		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	293	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CGACACTTGTGACAGAATGAC	0.453		NA											12	34					0	0	0	0
CHD4	1108	broad.mit.edu	37	12	6711546	6711546	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr12:6711546delT	uc001qpo.2	-	3	382	c.218delA	c.(217-219)AAGfs	p.K73fs	CHD4_uc001qpn.2_Frame_Shift_Del_p.K73fs|CHD4_uc001qpp.2_Frame_Shift_Del_p.K70fs	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	73					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ACTCACCTCCTTTTTTTGGCG	0.468		NA											7	393	---	---	---	---	NA	NA	NA	NA
SRRM2	23524	broad.mit.edu	37	16	2808519	2808519	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr16:2808519delG	uc002crk.2	+	5	1113	c.564delG	c.(562-564)AAGfs	p.K188fs	SRRM2_uc002crj.1_Frame_Shift_Del_p.K92fs|SRRM2_uc002crl.1_Frame_Shift_Del_p.K188fs|SRRM2_uc010bsu.1_Frame_Shift_Del_p.K92fs	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	188	Lys-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CAaagcagaagaagaagaaaa	0.413		NA											25	207	---	---	---	---	NA	NA	NA	NA
PSG3	5671	broad.mit.edu	37	19	43243011	43243011	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-6481-01A-11D-1870-08	TCGA-CR-6481-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5e7d2531-81c1-48bb-9c0a-1867d1f83f92	a09784cf-42b3-40c9-b7d0-d54a56563b7b	g.chr19:43243011delC	uc002oue.2	-	2	427	c.295delG	c.(295-297)GAAfs	p.E99fs	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Frame_Shift_Del_p.E121fs	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	99	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TATACTGTTTCTCGTCCACTG	0.453		NA											69	541	---	---	---	---	NA	NA	NA	NA