Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ZBTB48	3104	broad.mit.edu	37	1	6648997	6648997	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:6648997G>C	uc009vmc.1	+	11	1915	c.1792G>C	c.(1792-1794)GAG>CAG	p.E598Q	ZBTB48_uc001anx.2_Missense_Mutation_p.E598Q|ZBTB48_uc009vmd.1_Missense_Mutation_p.E598Q|ZBTB48_uc001any.1_Missense_Mutation_p.E236Q	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	598	C2H2-type 11.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GAGGCACATGGAGATCCACGA	0.662		NA											37	112					0	0	0	0
NPPA	4878	broad.mit.edu	37	1	11907385	11907385	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:11907385C>T	uc001ati.2	-	2	334	c.235G>A	c.(235-237)GAG>AAG	p.E79K	CLCN6_uc010oav.1_Intron|CLCN6_uc010oaw.1_Intron|CLCN6_uc010oax.1_Intron|CLCN6_uc010oay.1_Intron|CLCN6_uc010oaz.1_Intron|CLCN6_uc010oba.1_Intron	NM_006172	NP_006163	P01160	ANF_HUMAN	natriuretic peptide precursor A preproprotein	79					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGGCACCTCAGGGAGGGGG	0.617		NA											34	101					0	0	0	0
VPS13D	55187	broad.mit.edu	37	1	12328789	12328789	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:12328789G>A	uc001atv.2	+	16	1969	c.1828G>A	c.(1828-1830)GAG>AAG	p.E610K	VPS13D_uc001atw.2_Missense_Mutation_p.E610K	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	610					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCCCGTTTTTGAGATGCTGTA	0.468		NA											133	286					0	0	0	0
C1orf172	126695	broad.mit.edu	37	1	27277965	27277965	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:27277965G>A	uc001bni.1	-	2	996	c.907C>T	c.(907-909)CGC>TGC	p.R303C		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	303										large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GTACTAATGCGAATGATGCCG	0.607		NA											25	48					0	0	0	0
DNAJC8	22826	broad.mit.edu	37	1	28555483	28555483	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:28555483C>T	uc001bpn.2	-	2	163	c.130G>A	c.(130-132)GAA>AAA	p.E44K	DNAJC8_uc001bpo.2_RNA	NM_014280	NP_055095	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	44					nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		GTCAGTCTTTCAATCTGATTT	0.378		NA											43	111					0	0	0	0
KIF2C	11004	broad.mit.edu	37	1	45218850	45218850	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:45218850G>A	uc001cmg.3	+	6	601	c.486G>A	c.(484-486)TTG>TTA	p.L162L	KIF2C_uc010olb.1_Intron|KIF2C_uc010olc.1_Silent_p.L49L|KIF2C_uc001cmh.3_Silent_p.L108L	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	162	Globular (Potential).				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AAATACCATTGAGGATGGTCA	0.547		NA											51	98					0	0	0	0
HS2ST1	9653	broad.mit.edu	37	1	87538628	87538628	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:87538628G>A	uc010osk.1	+	2	521	c.136G>A	c.(136-138)GCA>ACA	p.A46T	HS2ST1_uc001dmc.3_Missense_Mutation_p.A46T|LOC339524_uc001dme.1_Missense_Mutation_p.A7T	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	46	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		AAGGGCTATTGCAAGACACGA	0.398		NA											14	42					0	0	0	0
GBP2	2634	broad.mit.edu	37	1	89582907	89582907	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:89582907C>T	uc001dmz.1	-	6	907	c.636G>A	c.(634-636)AAG>AAA	p.K212K	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	212					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		TTTTACTTTTCTTATCAGTAC	0.358		NA											32	32					0	0	0	0
GBP5	115362	broad.mit.edu	37	1	89730647	89730647	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:89730647G>C	uc001dnc.2	-	8	1408	c.871C>G	c.(871-873)CTA>GTA	p.L291V	GBP5_uc001dnd.2_Missense_Mutation_p.L291V|GBP5_uc001dne.1_Missense_Mutation_p.L291V	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	291						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		AGGTTCTTTAGACCTTCATGG	0.418		NA											35	72					0	0	0	0
C1orf59	113802	broad.mit.edu	37	1	109197402	109197402	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:109197402G>T	uc001dvt.3	-	5	572	c.334C>A	c.(334-336)CAT>AAT	p.H112N	C1orf59_uc001dvu.3_Missense_Mutation_p.H112N|C1orf59_uc009wer.2_Missense_Mutation_p.H112N	NM_001102592	NP_001096062	Q5T8I9	HENMT_HUMAN	hypothetical protein LOC113802	112					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity				0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0152)|Lung(183;0.0895)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.163)		ACGGAGCCATGATACAATGTG	0.383		NA											10	62					0.00010058	0.000104806	1	0
MAGI3	260425	broad.mit.edu	37	1	114133210	114133210	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:114133210G>A	uc001edk.2	+	5	1049	c.868G>A	c.(868-870)GAG>AAG	p.E290K	MAGI3_uc001edh.3_Missense_Mutation_p.E290K|MAGI3_uc001edi.3_Missense_Mutation_p.E290K|MAGI3_uc010owm.1_Missense_Mutation_p.E290K|MAGI3_uc001edj.2_Missense_Mutation_p.E11K	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	290					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGAGAGATGAGACTCTGGA	0.413		NA											23	112					0	0	0	0
MAGI3	260425	broad.mit.edu	37	1	114193781	114193781	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:114193781G>A	uc001edk.2	+	14	2574	c.2393G>A	c.(2392-2394)CGA>CAA	p.R798Q	MAGI3_uc001edh.3_Missense_Mutation_p.R823Q|MAGI3_uc001edi.3_Missense_Mutation_p.R798Q|MAGI3_uc010owm.1_Missense_Mutation_p.R823Q|MAGI3_uc001edj.2_Missense_Mutation_p.R519Q	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	823	Interaction with BAI1.|PDZ 4.			R -> P (in Ref. 2; AAG43837).	apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTGCTGCTCGAAATGGCCAT	0.433		NA											24	83					0	0	0	0
GATAD2B	57459	broad.mit.edu	37	1	153785835	153785835	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:153785835C>T	uc001fdb.3	-	8	1554	c.1310G>A	c.(1309-1311)GGT>GAT	p.G437D		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	437	GATA-type.|CR2.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TAGAATCTTACCATTCTTTTC	0.468		NA											41	103					0	0	0	0
C1orf104	284618	broad.mit.edu	37	1	155291198	155291198	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:155291198C>T	uc001fki.2	-	2	359	c.82G>A	c.(82-84)GAA>AAA	p.E28K	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_RNA|RUSC1_uc001fkj.2_Intron|RUSC1_uc001fkk.2_Intron|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	28											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GAGGTCCATTCTGGGCCCGGA	0.677		NA											6	24					0	0	0	0
DAP3	7818	broad.mit.edu	37	1	155686886	155686886	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:155686886G>A	uc001flq.2	+	3	304	c.135G>A	c.(133-135)CCG>CCA	p.P45P	DAP3_uc001flr.2_Silent_p.P45P|DAP3_uc001fls.2_Silent_p.P45P|DAP3_uc010pgl.1_Intron|DAP3_uc001flt.2_Silent_p.P45P|DAP3_uc001flu.2_Silent_p.P45P|DAP3_uc010pgm.1_Silent_p.P45P	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	45					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TTGAGAGTCCGAGAGCTATTT	0.423		NA											17	133					0	0	0	0
C1orf92	149499	broad.mit.edu	37	1	156897321	156897321	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:156897321C>T	uc001fqm.2	+	7	868	c.696C>T	c.(694-696)ATC>ATT	p.I232I	C1orf92_uc001fql.2_Silent_p.I17I	NM_144702	NP_653303	Q8N4P6	LRC71_HUMAN	hypothetical protein LOC149499	232	LRR 3.										0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACAATAACATCGACGACCGCG	0.627		NA											6	24					0	0	0	0
PEA15	8682	broad.mit.edu	37	1	160183267	160183267	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:160183267G>A	uc001fvk.2	+	4	574	c.384G>A	c.(382-384)AAG>AAA	p.K128K	PEA15_uc001fvl.2_Silent_p.K149K|PEA15_uc001fvm.2_Silent_p.K106K	NM_003768	NP_003759	Q15121	PEA15_HUMAN	phosphoprotein enriched in astrocytes 15	128	Microtubule-binding (Potential).				anti-apoptosis|apoptosis|carbohydrate transport|negative regulation of glucose import	cytoplasm|microtubule associated complex	protein binding				0	all_cancers(52;3.11e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCCCACCGAAGAAGGCCTGAG	0.577		NA											14	91					0	0	0	0
NCSTN	23385	broad.mit.edu	37	1	160327005	160327005	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:160327005C>T	uc001fvx.2	+	16	2093	c.1969C>T	c.(1969-1971)CGT>TGT	p.R657C	NCSTN_uc001fvy.2_Missense_Mutation_p.R637C|NCSTN_uc010pjf.1_Missense_Mutation_p.R519C|NCSTN_uc001fvz.2_Missense_Mutation_p.R437C|NCSTN_uc010pjg.1_Missense_Mutation_p.R399C	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	657	Extracellular (Potential).			R -> H (in Ref. 5; AAH47621).	amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAAAGATATCCGTGCCCGGAT	0.512		NA											19	43					0	0	0	0
CFHR4	10877	broad.mit.edu	37	1	196871632	196871632	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:196871632C>A	uc001gto.2	+	2	212	c.143C>A	c.(142-144)GCA>GAA	p.A48E	CFHR4_uc009wyy.2_Missense_Mutation_p.A47E|CFHR4_uc001gtp.2_Missense_Mutation_p.A48E	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	48	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						CCAGCAGCTGCAGGACAATCT	0.368		NA											148	91					5.38e-89	5.92e-89	1	0
CRB1	23418	broad.mit.edu	37	1	197404461	197404461	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:197404461C>T	uc001gtz.2	+	9	3603	c.3468C>T	c.(3466-3468)GAC>GAT	p.D1156D	CRB1_uc010poz.1_Silent_p.D1132D|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.D1044D|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Silent_p.D637D|CRB1_uc001gub.1_Silent_p.D805D	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1156	Extracellular (Potential).|EGF-like 15.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ACTGTGAAGACATCTATAGCT	0.443		NA											70	59					0	0	0	0
DDX59	83479	broad.mit.edu	37	1	200619777	200619777	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:200619777G>C	uc009wzk.2	-	5	1333	c.1090C>G	c.(1090-1092)CAA>GAA	p.Q364E	DDX59_uc010ppl.1_Missense_Mutation_p.Q364E	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	364	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ACTTGTTGTTGAAAACCCATC	0.358		NA											16	77					0	0	0	0
GOLT1A	127845	broad.mit.edu	37	1	204170910	204170910	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:204170910G>A	uc001has.1	-	3	333	c.147C>T	c.(145-147)ATC>ATT	p.I49I	GOLT1A_uc001hat.1_Silent_p.I49I	NM_198447	NP_940849	Q6ZVE7	GOT1A_HUMAN	golgi transport 1 homolog A	49	Helical; Name=2; (Potential).				protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane					0	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			TCAGGCCAATGATGAGGGACA	0.592		NA											35	115					0	0	0	0
NFASC	23114	broad.mit.edu	37	1	204951100	204951100	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:204951100G>A	uc001hbj.2	+	21	2750	c.2422G>A	c.(2422-2424)GGG>AGG	p.G808R	NFASC_uc010pra.1_Missense_Mutation_p.G804R|NFASC_uc001hbi.2_Missense_Mutation_p.G804R|NFASC_uc010prb.1_Missense_Mutation_p.G819R|NFASC_uc010prc.1_Missense_Mutation_p.G375R|NFASC_uc001hbk.1_Missense_Mutation_p.G614R|NFASC_uc001hbl.1_Missense_Mutation_p.G58R	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	808	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAATGACTTCGGGAAGGGCCC	0.602		NA											14	28					0	0	0	0
IL19	29949	broad.mit.edu	37	1	207010082	207010082	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:207010082C>T	uc001hep.2	+	3	1014	c.75C>T	c.(73-75)CTC>CTT	p.L25L	IL19_uc001heo.2_Silent_p.L63L|IL19_uc010prx.1_Silent_p.L25L	NM_013371	NP_037503	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 2 precursor	25					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			ACCACGGTCTCAGGAGATGTC	0.458		NA											43	218					0	0	0	0
INTS7	25896	broad.mit.edu	37	1	212180042	212180042	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:212180042A>G	uc001hiw.1	-	7	923	c.818T>C	c.(817-819)ATT>ACT	p.I273T	INTS7_uc009xdb.1_Missense_Mutation_p.I273T|INTS7_uc001hix.1_Missense_Mutation_p.I149T|INTS7_uc001hiy.1_Missense_Mutation_p.I273T|INTS7_uc010pta.1_Missense_Mutation_p.I224T	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	273					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CAGATCTTGAATAGCAAGTCT	0.313		NA											37	111					0	0	0	0
GALNT2	2590	broad.mit.edu	37	1	230386252	230386252	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:230386252G>A	uc010pwa.1	+	10	1027	c.955G>A	c.(955-957)GAA>AAA	p.E319K	GALNT2_uc010pvy.1_Missense_Mutation_p.E281K|GALNT2_uc010pvz.1_Intron	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	319	Lumenal (Potential).|Catalytic subdomain B.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GTTCTATTTTGAAGAACTGGG	0.493		NA											19	53					0	0	0	0
NID1	4811	broad.mit.edu	37	1	236180568	236180568	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:236180568C>G	uc001hxo.2	-	10	2236	c.2134G>C	c.(2134-2136)GAT>CAT	p.D712H	NID1_uc009xgd.2_Intron	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	712	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GAACATTCATCAATATCTGCA	0.393		NA											47	103					0	0	0	0
OR11L1	391189	broad.mit.edu	37	1	248004499	248004499	+	Missense_Mutation	SNP	G	G	A	rs147783465	byFrequency	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:248004499G>A	uc001idn.1	-	1	700	c.700C>T	c.(700-702)CGG>TGG	p.R234W		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTCTTTCTCCGGCCAGAGGTG	0.502		NA											37	115					0	0	0	0
OR2T2	401992	broad.mit.edu	37	1	248616452	248616452	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:248616452C>T	uc001iek.1	+	1	354	c.354C>T	c.(352-354)CTC>CTT	p.L118L		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCTGGGTCTCATGGCCTATG	0.547		NA											19	246					0	0	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24896476	24896476	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:24896476G>C	uc001isb.2	-	11	3123	c.2636C>G	c.(2635-2637)TCA>TGA	p.S879*	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Nonsense_Mutation_p.S879*|ARHGAP21_uc010qdc.1_Nonsense_Mutation_p.S714*	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	878					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						ATATGATTTTGATCTTTCTGT	0.383		NA											44	78					0	0	0	0
OGDHL	55753	broad.mit.edu	37	10	50966434	50966434	+	Splice_Site	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:50966434C>A	uc001jie.2	-	2	346	c.204_splice	c.e2+1	p.K68_splice	OGDHL_uc009xog.2_Intron|OGDHL_uc010qgt.1_Splice_Site_p.K68_splice|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_Intron	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a						glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGGATGCTGACCTTGTGGACA	0.602		NA											43	70					1.86e-20	2.01e-20	1	0
DKK1	22943	broad.mit.edu	37	10	54074713	54074713	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:54074713G>A	uc001jjr.2	+	2	428	c.274G>A	c.(274-276)GGC>AGC	p.G92S	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	92	DKK-type Cys-1.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						CGAGGAGTGCGGCACTGATGA	0.672		NA									OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55582924	55582924	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:55582924T>A	uc001jju.1	-	33	4957	c.4562A>T	c.(4561-4563)GAC>GTC	p.D1521V	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D1518V|PCDH15_uc010qhw.1_Missense_Mutation_p.D1481V|PCDH15_uc010qhx.1_Missense_Mutation_p.D1452V|PCDH15_uc010qhy.1_Missense_Mutation_p.D1528V|PCDH15_uc010qhz.1_Missense_Mutation_p.D1523V|PCDH15_uc010qia.1_Missense_Mutation_p.D1501V|PCDH15_uc010qib.1_Missense_Mutation_p.D1498V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1521	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GGCACTTAAGTCATCCTCATC	0.373		NA								HNSCC(58;0.16)			4	164					0	0	0	0
DDX50	79009	broad.mit.edu	37	10	70706381	70706381	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:70706381G>C	uc001jou.2	+	15	2316	c.2209G>C	c.(2209-2211)GAC>CAC	p.D737H	DDX50_uc010qjc.1_3'UTR	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	737						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1						ACGGAGTTTTGACTGAGTATT	0.423		NA											55	74					0	0	0	0
SORCS1	114815	broad.mit.edu	37	10	108536300	108536300	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:108536300C>T	uc001kym.2	-	4	885	c.877G>A	c.(877-879)GAC>AAC	p.D293N	SORCS1_uc001kyl.2_Missense_Mutation_p.D293N|SORCS1_uc009xxs.2_Missense_Mutation_p.D293N|SORCS1_uc001kyn.1_Missense_Mutation_p.D293N|SORCS1_uc001kyo.2_Missense_Mutation_p.D293N	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	293	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACCTTTTGGTCTTGACTGTAT	0.413		NA											7	153					0	0	0	0
SORCS1	114815	broad.mit.edu	37	10	108536327	108536327	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:108536327C>T	uc001kym.2	-	4	858	c.850G>A	c.(850-852)GAA>AAA	p.E284K	SORCS1_uc001kyl.2_Missense_Mutation_p.E284K|SORCS1_uc009xxs.2_Missense_Mutation_p.E284K|SORCS1_uc001kyn.1_Missense_Mutation_p.E284K|SORCS1_uc001kyo.2_Missense_Mutation_p.E284K	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	284	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATCCAGTCTTCTTGTTTGGGG	0.413		NA											57	93					0	0	0	0
SMC3	9126	broad.mit.edu	37	10	112362632	112362632	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:112362632C>T	uc001kze.2	+	27	3473	c.3347C>T	c.(3346-3348)TCA>TTA	p.S1116L		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	1116	Ala/Asp-rich (DA-box).				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		CAACAGCTTTCAGGTGGACAG	0.398		NA											29	97					0	0	0	0
GPAM	57678	broad.mit.edu	37	10	113932772	113932772	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr10:113932772G>A	uc009xxy.1	-	8	811	c.613C>T	c.(613-615)CAA>TAA	p.Q205*	GPAM_uc001kzp.2_Nonsense_Mutation_p.Q205*|GPAM_uc001kzq.1_Nonsense_Mutation_p.Q205*	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	205					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		TTGTGAATTTGAATGTTCCAA	0.373		NA											25	54					0	0	0	0
TRPM5	29850	broad.mit.edu	37	11	2428395	2428395	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:2428395G>A	uc001lwm.3	-	20	3081	c.3072C>T	c.(3070-3072)CTC>CTT	p.L1024L	TRPM5_uc010qxl.1_Silent_p.L1024L|TRPM5_uc009ydn.2_Silent_p.L1026L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	1024	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		AGACCCGGCGGAGCGTCAGGC	0.662		NA											8	8					0	0	0	0
OR52I1	390037	broad.mit.edu	37	11	4615302	4615302	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:4615302A>T	uc010qyi.1	+	1	34	c.34A>T	c.(34-36)ACC>TCC	p.T12S		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACAATGGAAACCCCTGCCTC	0.473		NA											14	253					0	0	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111451	7111451	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:7111451G>A	uc001mfc.2	+	1	1287	c.1100G>A	c.(1099-1101)CGG>CAG	p.R367Q		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	367	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCTTACAGCCGGTCAGGCTGC	0.652		NA											7	18					0	0	0	0
OR10A6	390093	broad.mit.edu	37	11	7949483	7949483	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:7949483C>T	uc010rbh.1	-	1	727	c.727G>A	c.(727-729)GCT>ACT	p.A243T		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTGAGGTGAGCGGCACAGGTG	0.453		NA											31	43					0	0	0	0
KIF18A	81930	broad.mit.edu	37	11	28057782	28057782	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:28057782T>C	uc001msc.2	-	14	2560	c.2378A>G	c.(2377-2379)AAC>AGC	p.N793S		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	793					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						AATGTCTTTGTTATCATTTGG	0.318		NA											32	40					0	0	0	0
OR4C3	256144	broad.mit.edu	37	11	48347158	48347158	+	Silent	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:48347158G>T	uc010rhv.1	+	1	666	c.666G>T	c.(664-666)CTG>CTT	p.L222L		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	195	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCATTGGTCTGCTGGTGGTTG	0.502		NA											36	68					6.85e-11	7.28e-11	1	0
POLD3	10714	broad.mit.edu	37	11	74351802	74351802	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:74351802G>C	uc001ovf.1	+	12	1467	c.1392G>C	c.(1390-1392)CAG>CAC	p.Q464H	POLD3_uc009yua.1_Missense_Mutation_p.Q358H	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	464					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					GCTTCTTCCAGAGGAAATAAA	0.468		NA											26	50					0	0	0	0
TRPC6	7225	broad.mit.edu	37	11	101342884	101342884	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:101342884G>A	uc001pgk.3	-	8	2614	c.2189C>T	c.(2188-2190)TCA>TTA	p.S730L	TRPC6_uc009ywy.2_Missense_Mutation_p.S614L|TRPC6_uc009ywz.1_Missense_Mutation_p.S675L	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	730	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TTCCTGGAATGAACTGTTGAT	0.328		NA											64	111					0	0	0	0
FAM55D	54827	broad.mit.edu	37	11	114453064	114453064	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:114453064G>A	uc001ppc.2	-	3	957	c.776C>T	c.(775-777)TCT>TTT	p.S259F	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	259						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		CTTGTTCTTAGAATACATGTG	0.398		NA											40	56					0	0	0	0
SPATA19	219938	broad.mit.edu	37	11	133712412	133712412	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr11:133712412G>C	uc001qgv.1	-	5	456	c.405C>G	c.(403-405)ATC>ATG	p.I135M		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	135					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GATCTCGCATGATGTCCTCTG	0.498		NA											55	83					0	0	0	0
PRMT8	56341	broad.mit.edu	37	12	3662836	3662836	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:3662836C>G	uc001qmf.2	+	4	804	c.437C>G	c.(436-438)TCT>TGT	p.S146C	PRMT8_uc009zed.2_Missense_Mutation_p.S137C|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	146					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			TCCAGTATTTCTGACTACTCA	0.418		NA											44	73					0	0	0	0
NTF3	4908	broad.mit.edu	37	12	5603698	5603698	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:5603698G>A	uc001qnl.3	+	1	401	c.318G>A	c.(316-318)CTG>CTA	p.L106L	NTF3_uc001qnk.3_Silent_p.L119L	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	106					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						GGGTCCTGCTGAGCGACAGCA	0.627		NA											14	76					0	0	0	0
CLEC6A	93978	broad.mit.edu	37	12	8618142	8618142	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:8618142G>A	uc001qum.1	+	4	403	c.286G>A	c.(286-288)GAA>AAA	p.E96K		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	96	Extracellular (Potential).|C-type lectin.				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					CATTTCCAGTGAAGAGAAGGT	0.423		NA											53	73					0	0	0	0
STRAP	11171	broad.mit.edu	37	12	16052888	16052888	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:16052888G>C	uc001rdc.3	+	8	1180	c.826G>C	c.(826-828)GAT>CAT	p.D276H	STRAP_uc010shw.1_Missense_Mutation_p.D289H|STRAP_uc001rdd.3_Missense_Mutation_p.D182H	NM_007178	NP_009109	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated	276	WD 7.				mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			skin(1)	1		Hepatocellular(102;0.121)				ATTTAGTCCTGATGGAGAACT	0.393		NA											45	76					0	0	0	0
ARNTL2	56938	broad.mit.edu	37	12	27553552	27553552	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:27553552C>A	uc001rht.1	+	10	1023	c.1005C>A	c.(1003-1005)AAC>AAA	p.N335K	ARNTL2_uc001rhw.2_Missense_Mutation_p.N298K|ARNTL2_uc010sjp.1_Missense_Mutation_p.N298K|ARNTL2_uc001rhu.1_Missense_Mutation_p.N321K|ARNTL2_uc009zji.1_Missense_Mutation_p.N301K|ARNTL2_uc001rhv.1_Missense_Mutation_p.N287K|uc001rhx.2_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	335					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					AAGAAAGGAACAGTAAGAAAG	0.373		NA											3	99					0.004672	0.00479917	1	0
CNTN1	1272	broad.mit.edu	37	12	41386958	41386958	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:41386958G>A	uc001rmm.1	+	17	2113	c.2000G>A	c.(1999-2001)AGA>AAA	p.R667K	CNTN1_uc001rmn.1_Missense_Mutation_p.R656K	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	667	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAGGCAGCAAGAGCAGTGGAC	0.383		NA											63	89					0	0	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48137435	48137435	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:48137435T>G	uc009zkp.2	-	17	2017	c.1577A>C	c.(1576-1578)GAC>GCC	p.D526A	RAPGEF3_uc001rpw.2_5'Flank|RAPGEF3_uc001rpx.2_5'UTR|RAPGEF3_uc010sln.1_Intron|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Missense_Mutation_p.D526A|RAPGEF3_uc001rpz.3_Missense_Mutation_p.D568A	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	526					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CACTGAGTGGTCTGGCCGGCA	0.627		NA											15	26					0	0	0	0
MFSD5	84975	broad.mit.edu	37	12	53647820	53647820	+	Silent	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:53647820C>A	uc001sci.1	+	2	1392	c.1201C>A	c.(1201-1203)CGA>AGA	p.R401R	MFSD5_uc001sch.1_Silent_p.R508R	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	401					transport	integral to membrane				skin(2)|ovary(1)	3						TGACAGTGATCGAAAAACAGG	0.547		NA											38	69					3.76e-14	4.03e-14	1	0
ESPL1	9700	broad.mit.edu	37	12	53675381	53675381	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:53675381C>T	uc001sck.2	+	13	2681	c.2590C>T	c.(2590-2592)CGA>TGA	p.R864*	ESPL1_uc001scj.2_Nonsense_Mutation_p.R539*|ESPL1_uc010soe.1_Nonsense_Mutation_p.R75*	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	864					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TGATCTGCTTCGAAGTCAACT	0.453		NA											64	100					0	0	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420738	55420738	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:55420738G>C	uc001sgp.3	+	2	893	c.515G>C	c.(514-516)GGA>GCA	p.G172A		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	172					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						CTGGTGGCTGGATGTCTCCAA	0.517		NA											32	55					0	0	0	0
SNRPF	6636	broad.mit.edu	37	12	96254999	96254999	+	Silent	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:96254999G>T	uc001tej.2	+	2	200	c.57G>T	c.(55-57)GTG>GTT	p.V19V		NM_003095	NP_003086	P62306	RUXF_HUMAN	small nuclear ribonucleoprotein polypeptide F	19					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0						GAAAGCCAGTGATGGTGAAAC	0.408		NA											42	61					1.47e-15	1.58e-15	1	0
SLC5A8	160728	broad.mit.edu	37	12	101587457	101587457	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:101587457C>T	uc001thz.3	-	5	1028	c.638G>A	c.(637-639)GGA>GAA	p.G213E		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	213	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						AGTGCTGATTCCACCTTGCAT	0.398		NA											73	89					0	0	0	0
KDM2B	84678	broad.mit.edu	37	12	121880818	121880818	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:121880818C>T	uc001uat.2	-	18	2685	c.2581G>A	c.(2581-2583)GAA>AAA	p.E861K	KDM2B_uc001uaq.2_Missense_Mutation_p.E301K|KDM2B_uc010szy.1_Missense_Mutation_p.E301K|KDM2B_uc001uar.2_Missense_Mutation_p.E452K|KDM2B_uc001uas.2_Missense_Mutation_p.E792K|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.E109K|KDM2B_uc010szx.1_Missense_Mutation_p.E109K|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	861					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGCTTATCTTCTTTGCCAGGT	0.592		NA											15	15					0	0	0	0
NCOR2	9612	broad.mit.edu	37	12	124934366	124934366	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:124934366G>C	uc010tba.1	-	7	927	c.810C>G	c.(808-810)ATC>ATG	p.I270M	NCOR2_uc010tay.1_Missense_Mutation_p.I270M|NCOR2_uc010taz.1_Missense_Mutation_p.I270M|NCOR2_uc010tbb.1_Missense_Mutation_p.I270M|NCOR2_uc010tbc.1_Missense_Mutation_p.I270M|NCOR2_uc001ugj.1_Missense_Mutation_p.I270M|NCOR2_uc001ugk.1_Missense_Mutation_p.I270M	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	270	Interaction with SIN3A/B (By similarity).				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CTCACATTTTGATGTTCTCAT	0.612		NA											17	31					0	0	0	0
EP400	57634	broad.mit.edu	37	12	132551372	132551372	+	Silent	SNP	A	A	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:132551372A>C	uc001ujn.2	+	48	8642	c.8607A>C	c.(8605-8607)GCA>GCC	p.A2869A	EP400_uc001ujl.2_Silent_p.A2868A|EP400_uc001ujm.2_Silent_p.A2788A|EP400_uc001ujp.2_Silent_p.A79A	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2905					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AGACCCAGGCACCCCAGCCAG	0.622		NA											8	48					0	0	0	0
NOC4L	79050	broad.mit.edu	37	12	132636125	132636125	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr12:132636125C>T	uc001ujz.1	+	12	1211	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F		NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	390	Helical; (Potential).				rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		TCCTGCCTTTCATCTGTAACC	0.721		NA											12	8					0	0	0	0
FLT1	2321	broad.mit.edu	37	13	29008329	29008329	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:29008329C>G	uc001usb.3	-	5	827	c.542G>C	c.(541-543)GGA>GCA	p.G181A	FLT1_uc010aar.1_Missense_Mutation_p.G181A|FLT1_uc001usc.3_Missense_Mutation_p.G181A|FLT1_uc010tdp.1_Missense_Mutation_p.G181A	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	181	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TATGCGTTTTCCATCAGGGAT	0.428		NA											19	76					0	0	0	0
TM9SF2	9375	broad.mit.edu	37	13	100192968	100192968	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:100192968G>C	uc001voj.1	+	8	962	c.829G>C	c.(829-831)GAA>CAA	p.E277Q	TM9SF2_uc010afz.1_Missense_Mutation_p.E112Q	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	277	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					TCTCCTCTAGGAAGATGATAA	0.388		NA											46	69					0	0	0	0
IRS2	8660	broad.mit.edu	37	13	110438062	110438062	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:110438062G>C	uc001vqv.2	-	1	853	c.339C>G	c.(337-339)ATC>ATG	p.I113M		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	113	PH.				fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TGTAGAGGGCGATCAGGTACT	0.622		NA											7	18					0	0	0	0
COL4A1	1282	broad.mit.edu	37	13	110838797	110838797	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr13:110838797G>A	uc001vqw.3	-	26	1954	c.1832C>T	c.(1831-1833)GCT>GTT	p.A611V	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	611	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AATGGGACCAGCAGGACCATA	0.607		NA											69	75					0	0	0	0
TEP1	7011	broad.mit.edu	37	14	20856088	20856088	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:20856088G>T	uc001vxe.2	-	18	2700	c.2660C>A	c.(2659-2661)CCC>CAC	p.P887H	TEP1_uc010ahk.2_Missense_Mutation_p.P237H|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.P779H	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	887					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGGAGCCAAGGGGCTTGGAGT	0.532		NA											32	71					4.92e-23	5.33e-23	1	0
SUPT16H	11198	broad.mit.edu	37	14	21829239	21829239	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:21829239C>T	uc001wao.2	-	16	2266	c.1927G>A	c.(1927-1929)GAG>AAG	p.E643K	SUPT16H_uc001wan.2_5'Flank	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	643					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		AGGCTCACCTCCTTCTCTTTC	0.368		NA											60	120					0	0	0	0
TM9SF1	10548	broad.mit.edu	37	14	24663958	24663958	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:24663958C>T	uc001wnb.1	-	2	616	c.268G>A	c.(268-270)GAG>AAG	p.E90K	TM9SF1_uc010toa.1_Missense_Mutation_p.E3K|TM9SF1_uc001wna.1_RNA|TM9SF1_uc010tob.1_Missense_Mutation_p.E325K|TM9SF1_uc001wnc.2_Missense_Mutation_p.E90K|TM9SF1_uc001wnd.2_5'Flank	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	90					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		TACAAAGACTCAGCCATTCGG	0.507		NA											174	297					0	0	0	0
TINF2	26277	broad.mit.edu	37	14	24710319	24710319	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:24710319G>A	uc001woa.3	-	5	853	c.511C>T	c.(511-513)CAG>TAG	p.Q171*	TINF2_uc010alm.2_5'UTR|TINF2_uc001wob.3_Nonsense_Mutation_p.Q171*|TINF2_uc010tof.1_Nonsense_Mutation_p.Q136*|TINF2_uc001woc.3_Intron	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	171					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		AGCACATCCTGAAGCTGTGGG	0.542		NA							Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis				116	137					0	0	0	0
PRKD1	5587	broad.mit.edu	37	14	30098292	30098292	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:30098292G>C	uc001wqh.2	-	11	1861	c.1680C>G	c.(1678-1680)ATC>ATG	p.I560M		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	560					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TACTCACAGAGATATCTCCTG	0.313		NA											29	37					0	0	0	0
HECTD1	25831	broad.mit.edu	37	14	31614087	31614087	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:31614087G>A	uc001wrc.1	-	16	3046	c.2557C>T	c.(2557-2559)CGT>TGT	p.R853C	HECTD1_uc001wrd.1_Missense_Mutation_p.R368C	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	853					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACTACTCCACGAGGCATGCTT	0.353		NA											23	28					0	0	0	0
SSTR1	6751	broad.mit.edu	37	14	38678915	38678915	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:38678915C>T	uc001wul.1	+	3	938	c.321C>T	c.(319-321)CTC>CTT	p.L107L	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	107	Helical; Name=2; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	ATGAGCTGCTCATGCTCAGCG	0.577		NA											90	163					0	0	0	0
C14orf135	64430	broad.mit.edu	37	14	60591509	60591509	+	Missense_Mutation	SNP	G	G	A	rs112427833	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:60591509G>A	uc001xer.3	+	8	2440	c.1918G>A	c.(1918-1920)GAT>AAT	p.D640N	C14orf135_uc001xeq.2_Missense_Mutation_p.D640N|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	874						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		TCCTGAAAACGATCTTTACAA	0.398		NA											7	206					0	0	0	0
NRXN3	9369	broad.mit.edu	37	14	79423682	79423682	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:79423682C>T	uc001xun.2	+	8	1745	c.1254C>T	c.(1252-1254)ACC>ACT	p.T418T	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.T543T	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	791	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTAAGTTAACCGTGGATGATG	0.493		NA											24	67					0	0	0	0
SLC24A4	123041	broad.mit.edu	37	14	92949145	92949145	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:92949145C>T	uc001yak.2	+	13	1350	c.1326C>T	c.(1324-1326)ACC>ACT	p.T442T	SLC24A4_uc001yai.2_Silent_p.T395T|SLC24A4_uc010twm.1_Silent_p.T440T|SLC24A4_uc001yaj.2_Silent_p.T423T|SLC24A4_uc010auj.2_Silent_p.T331T|SLC24A4_uc010twn.1_Silent_p.T215T|SLC24A4_uc001yan.2_Silent_p.T153T	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	459	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCTTCATCACCGCCACGCTGT	0.522		NA											24	21					0	0	0	0
CYP46A1	10858	broad.mit.edu	37	14	100192929	100192929	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:100192929G>A	uc001ygo.2	+	15	1368	c.1368G>A	c.(1366-1368)CAG>CAA	p.Q456Q	CYP46A1_uc001ygp.2_Silent_p.Q293Q	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	456					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				AGCTGCTGCAGAGGCTGGAGT	0.627		NA											3	1					0	0	0	0
JAG2	3714	broad.mit.edu	37	14	105609968	105609968	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr14:105609968C>T	uc001yqg.2	-	25	3496	c.3092G>A	c.(3091-3093)AGC>AAC	p.S1031N	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Missense_Mutation_p.S435N|JAG2_uc001yqh.2_Missense_Mutation_p.S993N	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1031	Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CCTGGCAGGGCTGAAGGACTG	0.682		NA											6	5					0	0	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42285087	42285087	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:42285087G>A	uc001zow.1	-	12	1231	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	PLA2G4E_uc010udc.1_5'UTR|PLA2G4E_uc001zov.1_Missense_Mutation_p.R64W	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	428	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		ACATGTCTCCGAGCCTCAAAG	0.572		NA											12	17					0	0	0	0
ZFP106	64397	broad.mit.edu	37	15	42734335	42734335	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:42734335C>T	uc001zpw.2	-	7	3965	c.3630G>A	c.(3628-3630)GAG>GAA	p.E1210E	ZFP106_uc001zpu.2_Silent_p.E395E|ZFP106_uc001zpv.2_Silent_p.E395E|ZFP106_uc001zpx.2_Silent_p.E438E	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	1210						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		CATTCACATTCTCATCTTGTT	0.463		NA											78	115					0	0	0	0
TLN2	83660	broad.mit.edu	37	15	63125727	63125727	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:63125727G>C	uc002alb.3	+	52	7027	c.7027G>C	c.(7027-7029)GAG>CAG	p.E2343Q	TLN2_uc002alc.3_Missense_Mutation_p.E736Q|TLN2_uc010uic.1_5'UTR|uc002ale.1_RNA	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2343	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CCTGGACTTTGAGGAACAGAT	0.498		NA											28	111					0	0	0	0
GRAMD2	196996	broad.mit.edu	37	15	72455741	72455741	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:72455741G>A	uc002atq.2	-	10	846	c.822C>T	c.(820-822)TGC>TGT	p.C274C	GRAMD2_uc010bis.2_Silent_p.C274C|GRAMD2_uc010ukh.1_Silent_p.C68C	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	274						integral to membrane					0						TCTTCTTAGGGCAGGCAGGAC	0.542		NA											68	76					0	0	0	0
SYNM	23336	broad.mit.edu	37	15	99670618	99670618	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:99670618G>A	uc002bup.2	+	6	2173	c.2053G>A	c.(2053-2055)GAA>AAA	p.E685K	SYNM_uc002buo.2_Missense_Mutation_p.E685K|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	685	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						AACAAAGACTGAAATAGTTGT	0.443		NA											17	20					0	0	0	0
ZNF213	7760	broad.mit.edu	37	16	3190831	3190831	+	Missense_Mutation	SNP	C	C	T	rs113065910		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:3190831C>T	uc010uws.1	+	6	1310	c.863C>T	c.(862-864)GCG>GTG	p.A288V	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Missense_Mutation_p.A288V|ZNF213_uc010uwt.1_3'UTR	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	288	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CGGCCGAGGGCGGCCCTGGGC	0.746		NA											12	11					0	0	0	0
NPIP	9284	broad.mit.edu	37	16	15045778	15045778	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:15045778C>T	uc002dcy.3	+	8	949	c.949C>T	c.(949-951)CCA>TCA	p.P317S	NPIP_uc002dcx.3_RNA	NM_006985	NP_008916	Q9UND3	NPIP_HUMAN	nuclear pore complex interacting protein	317	Pro-rich.				mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						CACTCCCCTTCCACCCTCAGC	0.532		NA											4	63					0	0	0	0
ACSM2A	123876	broad.mit.edu	37	16	20487094	20487094	+	Missense_Mutation	SNP	C	C	T	rs150888398	byFrequency	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:20487094C>T	uc010bwe.2	+	9	1336	c.1097C>T	c.(1096-1098)ACG>ATG	p.T366M	ACSM2A_uc010vax.1_Missense_Mutation_p.T287M|ACSM2A_uc002dhf.3_Missense_Mutation_p.T366M|ACSM2A_uc002dhg.3_Missense_Mutation_p.T366M|ACSM2A_uc010vay.1_Missense_Mutation_p.T287M|ACSM2A_uc002dhh.3_Translation_Start_Site	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	366					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CAGACAGAAACGGTACCTGTT	0.473		NA											101	172					0	0	0	0
GGA2	23062	broad.mit.edu	37	16	23491207	23491207	+	Silent	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:23491207G>C	uc002dlq.2	-	11	1084	c.1008C>G	c.(1006-1008)GTC>GTG	p.V336V	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	336	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		GATTCTGAAAGACTAGAAAGC	0.502		NA											15	22					0	0	0	0
COG4	25839	broad.mit.edu	37	16	70543161	70543161	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:70543161G>T	uc002ezc.2	-	7	986	c.975C>A	c.(973-975)TTC>TTA	p.F325L	COG4_uc002ezb.2_5'UTR|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.F325L|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	321					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TTTGCTTGATGAACTTGTCTA	0.483		NA											45	77					8.21e-20	8.86e-20	1	0
AP1G1	164	broad.mit.edu	37	16	71798596	71798596	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:71798596G>A	uc010cgg.2	-	8	1086	c.772C>T	c.(772-774)CGA>TGA	p.R258*	AP1G1_uc002fba.2_Nonsense_Mutation_p.R261*|AP1G1_uc002fbb.2_Nonsense_Mutation_p.R281*|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	258					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				TCATCATTTCGTCCTAAAATT	0.328		NA											17	38					0	0	0	0
CA5A	763	broad.mit.edu	37	16	87970028	87970028	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr16:87970028G>A	uc002fkn.1	-	1	85	c.29C>T	c.(28-30)TCA>TTA	p.S10L		NM_001739	NP_001730	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial precursor	10					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)		GGAGAAAGCTGAGGTCTTCCA	0.542		NA											63	82					0	0	0	0
NLGN2	57555	broad.mit.edu	37	17	7320306	7320306	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:7320306G>A	uc002ggt.1	+	7	1769	c.1696G>A	c.(1696-1698)GAG>AAG	p.E566K		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	566	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				CAATCGCTTCGAGGAGGTGGT	0.597		NA											24	21					0	0	0	0
MYH10	4628	broad.mit.edu	37	17	8411946	8411946	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:8411946G>T	uc002gll.2	-	24	3143	c.3047C>A	c.(3046-3048)GCT>GAT	p.A1016D	MYH10_uc002glm.2_Missense_Mutation_p.A1047D|MYH10_uc010cnx.2_Missense_Mutation_p.A1025D	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1016	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTCCTCTTCAGCCAGCTGAGA	0.413		NA											80	119					5.42e-27	5.91e-27	1	0
WDR16	146845	broad.mit.edu	37	17	9532073	9532073	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:9532073C>T	uc002gly.2	+	9	1179	c.1110C>T	c.(1108-1110)ATC>ATT	p.I370I	WDR16_uc002glz.2_Silent_p.I302I|WDR16_uc010coc.2_Silent_p.I380I	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	370						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TGCTGCGGATCACCGTGCCCA	0.542		NA											27	40					0	0	0	0
PRPSAP2	5636	broad.mit.edu	37	17	18769186	18769186	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:18769186A>T	uc002gup.1	+	3	251	c.40A>T	c.(40-42)AAC>TAC	p.N14Y	PRPSAP2_uc002guo.1_5'UTR|PRPSAP2_uc010vyi.1_Missense_Mutation_p.N2Y|PRPSAP2_uc010vyj.1_5'UTR|PRPSAP2_uc010vyk.1_Missense_Mutation_p.N2Y	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	14					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						AACCAAGATGAACATAACCAA	0.348		NA											16	31					0	0	0	0
TMIGD1	388364	broad.mit.edu	37	17	28644217	28644217	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:28644217G>C	uc002hfa.1	-	6	852	c.779C>G	c.(778-780)ACA>AGA	p.T260R	TMIGD1_uc010csh.1_3'UTR	NM_206832	NP_996663	Q6UXZ0	TMIG1_HUMAN	transmembrane and immunoglobulin domain	260	Cytoplasmic (Potential).					integral to membrane					0						TTACAGAGCTGTTTCACTGTG	0.423		NA											31	75					0	0	0	0
KRT38	8687	broad.mit.edu	37	17	39594463	39594463	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:39594463C>T	uc002hwq.1	-	6	1546	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	375	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GCCCGGATCTCAGACAGCTGC	0.612		NA											25	40					0	0	0	0
JUP	3728	broad.mit.edu	37	17	39680030	39680030	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:39680030G>A	uc010wfs.1	-	9	1665	c.1657C>T	c.(1657-1659)CAC>TAC	p.H553Y	KRT15_uc002hxb.1_5'Flank|uc002hxc.1_5'Flank|KRT19_uc002hxd.3_Missense_Mutation_p.H390Y	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TTGTTGTAGTGATCTTCCTGT	0.582		NA											16	45					0	0	0	0
EFTUD2	9343	broad.mit.edu	37	17	42934459	42934459	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:42934459C>T	uc002ihn.2	-	20	2290	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K	EFTUD2_uc010wje.1_Missense_Mutation_p.E642K|EFTUD2_uc010wjf.1_Missense_Mutation_p.E667K	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	677						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				TTAGGCGTTTCAGCAAAGCAC	0.507		NA											33	46					0	0	0	0
FAM117A	81558	broad.mit.edu	37	17	47797228	47797228	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:47797228G>A	uc002ipk.2	-	5	671	c.602C>T	c.(601-603)TCC>TTC	p.S201F	FAM117A_uc010wlz.1_5'UTR	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	201										ovary(1)	1						CAAGACAGGGGACCCTGAGGG	0.587		NA											18	27					0	0	0	0
KIF19	124602	broad.mit.edu	37	17	72349698	72349698	+	Silent	SNP	G	G	A	rs146555239	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:72349698G>A	uc002jkm.3	+	17	2424	c.2286G>A	c.(2284-2286)TCG>TCA	p.S762S		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	762					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						AGAACCTGTCGGAGATCCCCT	0.592		NA											13	27					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78320969	78320969	+	Missense_Mutation	SNP	G	G	A	rs76918558		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr17:78320969G>A	uc002jyh.1	+	4	3276	c.3053G>A	c.(3052-3054)CGC>CAC	p.R1018H		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTGTGTAAGCGCCAGGACAAG	0.532		NA											6	17					0	0	0	0
LAMA3	3909	broad.mit.edu	37	18	21402267	21402267	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:21402267C>T	uc002kuq.2	+	20	2442	c.2356C>T	c.(2356-2358)CGT>TGT	p.R786C	LAMA3_uc002kur.2_Missense_Mutation_p.R786C	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	786					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCCTTGTTTCGTGTTATTCT	0.383		NA											33	59					0	0	0	0
ASXL3	80816	broad.mit.edu	37	18	31325316	31325316	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:31325316T>C	uc010dmg.1	+	12	5559	c.5504T>C	c.(5503-5505)GTA>GCA	p.V1835A	ASXL3_uc002kxq.2_Missense_Mutation_p.V1542A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCTAGGACTGTAGGAGAACAC	0.478		NA											8	272					0	0	0	0
CXXC1	30827	broad.mit.edu	37	18	47812521	47812521	+	Silent	SNP	C	C	T	rs149686544	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:47812521C>T	uc002leq.3	-	4	1063	c.330G>A	c.(328-330)AAG>AAA	p.K110K	CXXC1_uc002lep.3_5'UTR|CXXC1_uc002ler.3_Silent_p.K110K|CXXC1_uc010doy.2_Silent_p.K110K|CXXC1_uc002les.2_Silent_p.K110K	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	110					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGACAGGCCTCTTGCGCCCTC	0.647		NA											57	87					0	0	0	0
MRO	83876	broad.mit.edu	37	18	48331680	48331680	+	Silent	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:48331680G>C	uc002lew.3	-	5	567	c.273C>G	c.(271-273)CTC>CTG	p.L91L	MRO_uc010xdn.1_Silent_p.L91L|MRO_uc010dpa.2_Silent_p.L105L|MRO_uc010dpb.2_Silent_p.L105L|MRO_uc010dpc.2_Silent_p.L91L|MRO_uc002lex.3_Silent_p.L91L	NM_031939	NP_114145	Q9BYG7	MSTRO_HUMAN	maestro isoform a	91						nucleolus	binding				0		Colorectal(6;0.0596)		Colorectal(21;0.082)		CCAGCAGGTCGAGGACAATTT	0.463		NA											39	54					0	0	0	0
CDH20	28316	broad.mit.edu	37	18	59221574	59221574	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:59221574G>C	uc010dps.1	+	11	2064	c.2052G>C	c.(2050-2052)TGG>TGC	p.W684C	CDH20_uc002lif.2_Missense_Mutation_p.W678C	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	684	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CGGCCATGTGGAACCCCCGGG	0.682		NA											38	63					0	0	0	0
ZNF407	55628	broad.mit.edu	37	18	72346054	72346054	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr18:72346054C>G	uc002llw.2	+	1	3136	c.3079C>G	c.(3079-3081)CAC>GAC	p.H1027D	ZNF407_uc010xfc.1_Missense_Mutation_p.H1027D|ZNF407_uc010dqu.1_Missense_Mutation_p.H1027D|ZNF407_uc002llu.2_Missense_Mutation_p.H1026D	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1027	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GTTTAGTGCTCACTCCTCTGC	0.488		NA											59	92					0	0	0	0
SF3A2	8175	broad.mit.edu	37	19	2247868	2247868	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:2247868G>A	uc002lvg.2	+	9	840	c.718G>A	c.(718-720)GGT>AGT	p.G240S	AMH_uc002lvh.2_5'Flank|hsa-mir-4321|MI0015852_5'Flank	NM_007165	NP_009096	Q15428	SF3A2_HUMAN	splicing factor 3a, subunit 2	240	Pro-rich.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex	nucleic acid binding|zinc ion binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGATGAACGGTCTGCCCCC	0.706		NA											10	40					0	0	0	0
VAV1	7409	broad.mit.edu	37	19	6828659	6828659	+	Silent	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:6828659C>G	uc002mfu.1	+	12	1216	c.1119C>G	c.(1117-1119)GTC>GTG	p.V373V	VAV1_uc010xjh.1_Silent_p.V341V|VAV1_uc010dva.1_Silent_p.V373V|VAV1_uc002mfv.1_Silent_p.V318V	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	373	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TGAACGAGGTCAAGCGAGACA	0.637		NA											35	306					0	0	0	0
TIMM44	10469	broad.mit.edu	37	19	7998423	7998423	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:7998423G>A	uc002miz.2	-	7	718	c.716C>T	c.(715-717)TCC>TTC	p.S239F	TIMM44_uc002mja.2_5'UTR|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	239					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						GTACCACTTGGAGTCCTTGTG	0.647		NA											134	373					0	0	0	0
MYO1F	4542	broad.mit.edu	37	19	8606807	8606807	+	Silent	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:8606807C>G	uc002mkg.2	-	15	1707	c.1593G>C	c.(1591-1593)CTG>CTC	p.L531L		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	531	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						TGGTCTGCATCAGCTCTATGA	0.622		NA											27	78					0	0	0	0
MYO1F	4542	broad.mit.edu	37	19	8616660	8616660	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:8616660G>A	uc002mkg.2	-	8	849	c.735C>T	c.(733-735)GAC>GAT	p.D245D	MYO1F_uc002mkh.2_Silent_p.D245D|MYO1F_uc010xkf.1_3'UTR	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	245	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CGTCCGTGCCGTCCACCTGGT	0.607		NA											49	118					0	0	0	0
OR1M1	125963	broad.mit.edu	37	19	9204176	9204176	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:9204176C>T	uc010xkj.1	+	1	256	c.256C>T	c.(256-258)CAA>TAA	p.Q86*		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						GGTGAGCCTTCAAACCGGGAG	0.537		NA											34	214					0	0	0	0
ACP5	54	broad.mit.edu	37	19	11687634	11687634	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:11687634C>G	uc002msg.3	-	3	432	c.286G>C	c.(286-288)GAC>CAC	p.D96H	ACP5_uc002msh.3_Missense_Mutation_p.D96H|ACP5_uc002msi.3_Missense_Mutation_p.D96H|ACP5_uc002msj.3_Missense_Mutation_p.D96H|ACP5_uc010dye.1_3'UTR	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	96					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						AGGGAGCGGTCAGAGAATACG	0.547		NA											36	108					0	0	0	0
CC2D1A	54862	broad.mit.edu	37	19	14040932	14040932	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:14040932G>A	uc002mxo.2	+	27	3051	c.2752G>A	c.(2752-2754)GAG>AAG	p.E918K	CC2D1A_uc002mxp.2_Missense_Mutation_p.E917K|CC2D1A_uc010dzh.2_Missense_Mutation_p.E487K	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	918					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GTTCTACACGGAGGCTGCCCG	0.687		NA											8	21					0	0	0	0
JAK3	3718	broad.mit.edu	37	19	17945733	17945733	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:17945733C>G	uc002nhn.3	-	16	2227	c.2127G>C	c.(2125-2127)TGG>TGC	p.W709C	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Missense_Mutation_p.W709C	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	709	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CGCCGAAGCCCCACTTGTCAG	0.617		2	Mis		acute megakaryocytic leukemia|								51	118					0	0	0	0
MAST3	23031	broad.mit.edu	37	19	18252811	18252811	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:18252811G>A	uc002nhz.3	+	20	2238	c.2238G>A	c.(2236-2238)CTG>CTA	p.L746L		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	746							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GCCGCCGGCTGAGTGCTGACA	0.597		NA											4	16					0	0	0	0
GMIP	51291	broad.mit.edu	37	19	19740868	19740868	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:19740868C>T	uc002nnd.2	-	21	2934	c.2817G>A	c.(2815-2817)GAG>GAA	p.E939E	LPAR2_uc002nnb.3_5'Flank|LPAR2_uc002nna.3_5'Flank|LPAR2_uc002nnc.3_5'Flank|GMIP_uc010xrb.1_Silent_p.E913E|GMIP_uc010xrc.1_Silent_p.E910E	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	939					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						GCCGGGCTGTCTCCTGGGTAA	0.682		NA											6	14					0	0	0	0
CCDC123	84902	broad.mit.edu	37	19	33370171	33370171	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:33370171C>T	uc002nty.2	-	19	2338	c.2249G>A	c.(2248-2250)AGA>AAA	p.R750K	CCDC123_uc002ntx.2_Missense_Mutation_p.R503K|CCDC123_uc010edg.2_RNA	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	750						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					AACCAGAGCTCTGGGGTTGTC	0.562		NA											71	168					0	0	0	0
ZNF573	126231	broad.mit.edu	37	19	38230601	38230601	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:38230601G>A	uc002ohe.2	-	4	812	c.790C>T	c.(790-792)CAT>TAT	p.H264Y	ZNF573_uc010efs.2_Missense_Mutation_p.H177Y|ZNF573_uc002ohd.2_Missense_Mutation_p.H262Y|ZNF573_uc002ohf.2_Missense_Mutation_p.H206Y|ZNF573_uc002ohg.2_Missense_Mutation_p.H176Y	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	244	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			ACTCTCTGATGAATTCTAAGA	0.428		NA											68	165					0	0	0	0
RYR1	6261	broad.mit.edu	37	19	38976258	38976258	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:38976258C>T	uc002oit.2	+	34	5093	c.4963C>T	c.(4963-4965)CGC>TGC	p.R1655C	RYR1_uc002oiu.2_Missense_Mutation_p.R1655C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1655	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTGTCGGAGCGCCTGGACCT	0.602		NA											22	74					0	0	0	0
CAPN12	147968	broad.mit.edu	37	19	39230743	39230743	+	Missense_Mutation	SNP	G	G	C	rs148710823	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:39230743G>C	uc002ojd.1	-	5	986	c.677C>G	c.(676-678)TCT>TGT	p.S226C		NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	226	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			GCGCAGGGCAGAGAACAGCCC	0.627		NA											8	37					0	0	0	0
GRIK5	2901	broad.mit.edu	37	19	42510807	42510807	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:42510807G>T	uc002osj.1	-	15	2062	c.2027C>A	c.(2026-2028)ACC>AAC	p.T676N	GRIK5_uc002osi.1_Missense_Mutation_p.T248N	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	676	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTGGAAGAAGGTCATGGTGGA	0.622		NA											7	28					2.74e-10	2.91e-10	1	0
POU2F2	5452	broad.mit.edu	37	19	42599758	42599758	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:42599758C>T	uc002osp.2	-	10	960	c.893G>A	c.(892-894)CGC>CAC	p.R298H	POU2F2_uc002osn.2_Missense_Mutation_p.R282H|POU2F2_uc002oso.2_Missense_Mutation_p.R71H|POU2F2_uc002osq.2_Missense_Mutation_p.R282H|POU2F2_uc002osr.1_Missense_Mutation_p.R298H	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	298	Homeobox.				humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				CCTCTTCTTGCGTCTCCGGCC	0.647		NA											8	29					0	0	0	0
SYMPK	8189	broad.mit.edu	37	19	46319745	46319745	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:46319745C>G	uc002pdn.2	-	25	3594	c.3349G>C	c.(3349-3351)GAG>CAG	p.E1117Q	RSPH6A_uc002pdm.2_5'Flank	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	1117					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CTCACCTCCTCCAAGGGCCCC	0.657		NA											9	28					0	0	0	0
RPL28	6158	broad.mit.edu	37	19	55899356	55899356	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:55899356C>T	uc002qkv.2	+	4	306	c.264C>T	c.(262-264)GCC>GCT	p.A88A	RPL28_uc010yga.1_Silent_p.A88A|RPL28_uc010ygb.1_Silent_p.A88A|RPL28_uc002qkw.1_3'UTR	NM_000991	NP_000982	P46779	RL28_HUMAN	ribosomal protein L28 isoform 2	88					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		ATGCTCGCGCCACGCTCAGCA	0.622		NA											52	139					0	0	0	0
ZNF835	90485	broad.mit.edu	37	19	57175433	57175433	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:57175433G>A	uc010ygo.1	-	2	1200	c.1200C>T	c.(1198-1200)CTC>CTT	p.L400L	ZNF835_uc010ygn.1_Silent_p.L378L	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GGCGGTGCTGGAGGAGGTGGG	0.667		NA											8	36					0	0	0	0
ZNF549	256051	broad.mit.edu	37	19	58048682	58048682	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:58048682C>T	uc002qpb.1	+	4	559	c.310C>T	c.(310-312)CAT>TAT	p.H104Y	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.H91Y	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	104	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCAAATGCTCATTCTTGTGA	0.512		NA											49	138					0	0	0	0
ZNF211	10520	broad.mit.edu	37	19	58153100	58153100	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:58153100C>T	uc002qpq.2	+	3	1426	c.1246C>T	c.(1246-1248)CGG>TGG	p.R416W	ZNF211_uc010yhb.1_Missense_Mutation_p.R420W|ZNF211_uc002qpp.2_Missense_Mutation_p.R429W|ZNF211_uc002qpr.2_Missense_Mutation_p.R480W|ZNF211_uc002qps.2_Missense_Mutation_p.R481W|ZNF211_uc002qpt.2_Missense_Mutation_p.R428W|ZNF211_uc010yhc.1_Missense_Mutation_p.R428W|ZNF211_uc010yhd.1_Missense_Mutation_p.R355W|ZNF211_uc010yhe.1_Missense_Mutation_p.R407W	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	416	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATTCACCACCGGAGACTTCA	0.478		NA											39	77					0	0	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58189590	58189590	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr19:58189590G>T	uc002qpu.2	+	5	1316	c.619G>T	c.(619-621)GAA>TAA	p.E207*		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	207					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCGAGTAAATGAAAATATTAC	0.403		NA											32	70					4.21e-06	4.43e-06	1	0
MYT1L	23040	broad.mit.edu	37	2	1843083	1843083	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:1843083C>T	uc002qxe.2	-	21	3745	c.2918G>A	c.(2917-2919)CGC>CAC	p.R973H	MYT1L_uc002qxd.2_Missense_Mutation_p.R971H|MYT1L_uc010ewk.2_5'UTR	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	973	C2HC-type 5.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGAGGCGCTGCGATGGGACGC	0.632		NA											53	52					0	0	0	0
MYT1L	23040	broad.mit.edu	37	2	1926709	1926709	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:1926709C>A	uc002qxe.2	-	10	1659	c.832G>T	c.(832-834)GAA>TAA	p.E278*	MYT1L_uc002qxd.2_Nonsense_Mutation_p.E278*|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	278					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TTCATGTTTTCTGAGAGCACA	0.423		NA											84	131					1.43e-55	1.57e-55	1	0
NBAS	51594	broad.mit.edu	37	2	15417101	15417101	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:15417101C>G	uc002rcc.1	-	43	5289	c.5263G>C	c.(5263-5265)GAT>CAT	p.D1755H	NBAS_uc010exl.1_Missense_Mutation_p.D827H|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1755										ovary(2)|liver(1)|skin(1)	4						CTTTCGTGATCAAAGCCACCA	0.443		NA											23	40					0	0	0	0
CLIP4	79745	broad.mit.edu	37	2	29356671	29356671	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:29356671C>T	uc002rmv.2	+	5	757	c.518C>T	c.(517-519)TCG>TTG	p.S173L	CLIP4_uc002rmu.2_Missense_Mutation_p.S173L|CLIP4_uc010ezm.1_Missense_Mutation_p.S173L|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Missense_Mutation_p.S155L	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	173	ANK 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TTGAAAACATCGAAACCAAAA	0.333		NA											27	54					0	0	0	0
VIT	5212	broad.mit.edu	37	2	36956606	36956606	+	Silent	SNP	G	G	A	rs147850488		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:36956606G>A	uc002rpl.2	+	3	311	c.90G>A	c.(88-90)ACG>ACA	p.T30T	VIT_uc002rpk.2_Silent_p.T23T|VIT_uc010ynf.1_Silent_p.T23T|VIT_uc002rpm.2_Silent_p.T23T|VIT_uc010ezv.2_Silent_p.T23T|VIT_uc010ezw.2_Silent_p.T23T	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	30						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				ACAAAGAAACGGCAAAGAAGA	0.299		NA											32	57					0	0	0	0
KLRAQ1	129285	broad.mit.edu	37	2	48681851	48681851	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:48681851C>T	uc002rwm.2	+	3	429	c.244C>T	c.(244-246)CTA>TTA	p.L82L	KLRAQ1_uc002rwi.1_Silent_p.L82L|KLRAQ1_uc002rwj.2_Silent_p.L82L|KLRAQ1_uc002rwl.2_Silent_p.L36L|KLRAQ1_uc002rwk.2_Silent_p.L82L|KLRAQ1_uc010yok.1_Silent_p.L82L	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	82	Potential.									ovary(1)	1						TGAACTAGCTCTAAGTGAACC	0.428		NA											33	43					0	0	0	0
MEIS1	4211	broad.mit.edu	37	2	66691284	66691284	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:66691284C>T	uc002sdu.2	+	7	1131	c.674C>T	c.(673-675)TCA>TTA	p.S225L	MEIS1_uc002sdt.2_Missense_Mutation_p.S225L|MEIS1_uc002sdv.2_Missense_Mutation_p.S223L|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Missense_Mutation_p.S160L|MEIS1_uc002sdw.1_Missense_Mutation_p.S81L	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	225	Ser/Thr-rich.						sequence-specific DNA binding transcription factor activity				0						TCTACTCGTTCAGGAGGAACC	0.512		NA											3	10					0	0	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459920	107459920	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:107459920G>A	uc002tdq.2	-	2	633	c.514C>T	c.(514-516)CGG>TGG	p.R172W	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R172W|ST6GAL2_uc002tds.3_Missense_Mutation_p.R172W	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	172	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TTCTTCACCCGCCTCCTCTGG	0.657		NA											53	81					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165995989	165995989	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:165995989C>T	uc002ucx.2	-	14	2641	c.2149G>A	c.(2149-2151)GAA>AAA	p.E717K	SCN3A_uc002ucy.2_Missense_Mutation_p.E668K|SCN3A_uc002ucz.2_Missense_Mutation_p.E668K|SCN3A_uc002uda.1_Missense_Mutation_p.E537K|SCN3A_uc002udb.1_Missense_Mutation_p.E537K	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	717						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTCTTACCTTCCATTGTGTTG	0.433		NA											41	38					0	0	0	0
TTC21B	79809	broad.mit.edu	37	2	166758288	166758288	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:166758288C>T	uc002udk.2	-	20	2834	c.2701G>A	c.(2701-2703)GAA>AAA	p.E901K		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	901	TPR 13.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						ATTGCTTTTTCATAGTCTCGC	0.368		NA											23	37					0	0	0	0
SCN7A	6332	broad.mit.edu	37	2	167334107	167334107	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:167334107C>T	uc002udu.1	-	2	227	c.100G>A	c.(100-102)GAA>AAA	p.E34K	SCN7A_uc002udv.1_Missense_Mutation_p.E34K	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	34					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TCTTCTTCTTCATGGTCTTCA	0.388		NA											10	10					0	0	0	0
STAT1	6772	broad.mit.edu	37	2	191873691	191873691	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:191873691G>A	uc002usj.2	-	4	659	c.271C>T	c.(271-273)CAG>TAG	p.Q91*	STAT1_uc010fse.1_Nonsense_Mutation_p.Q91*|STAT1_uc002usk.2_Nonsense_Mutation_p.Q91*|STAT1_uc002usl.2_Nonsense_Mutation_p.Q93*|STAT1_uc010fsf.1_5'UTR	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	91					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GGTCATACCTGAAGATTACGC	0.368		NA											26	3					0	0	0	0
ABCA12	26154	broad.mit.edu	37	2	215843708	215843708	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:215843708G>A	uc002vew.2	-	32	5017	c.4797C>T	c.(4795-4797)ATC>ATT	p.I1599I	ABCA12_uc002vev.2_Silent_p.I1281I|ABCA12_uc010zjn.1_Silent_p.I526I	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1599					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GATGTGATTGGATCATTGCTG	0.448		NA											44	48					0	0	0	0
GIGYF2	26058	broad.mit.edu	37	2	233704679	233704679	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:233704679G>C	uc002vti.3	+	25	3224	c.2887G>C	c.(2887-2889)GAG>CAG	p.E963Q	GIGYF2_uc002vtj.3_Missense_Mutation_p.E984Q|GIGYF2_uc002vtk.3_Missense_Mutation_p.E963Q|GIGYF2_uc002vth.3_Missense_Mutation_p.E957Q|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Missense_Mutation_p.E794Q|GIGYF2_uc002vtq.3_Missense_Mutation_p.E296Q	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	963	Gln-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCTTCGAGAAGAGGTAAAATT	0.448		NA											9	23					0	0	0	0
C2orf54	79919	broad.mit.edu	37	2	241834961	241834961	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr2:241834961G>A	uc002wae.3	-	1	613	c.454C>T	c.(454-456)CTC>TTC	p.L152F		NM_001085437	NP_001078906	Q08AI8	CB054_HUMAN	hypothetical protein LOC79919 isoform 1	152											0		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		AGGTCCTTGAGGACACACAGG	0.607		NA											6	14					0	0	0	0
PLCB4	5332	broad.mit.edu	37	20	9416276	9416276	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:9416276G>A	uc002wnf.2	+	27	2694	c.2558G>A	c.(2557-2559)AGA>AAA	p.R853K	PLCB4_uc010gbw.1_Missense_Mutation_p.R853K|PLCB4_uc010gbx.2_Missense_Mutation_p.R865K|PLCB4_uc002wne.2_Missense_Mutation_p.R853K|PLCB4_uc002wnh.2_Missense_Mutation_p.R700K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	853					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GACCAAATGAGAGCTATGGGC	0.368		NA											28	79					0	0	0	0
CHD6	84181	broad.mit.edu	37	20	40065914	40065914	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:40065914C>T	uc002xka.1	-	27	4246	c.4068G>A	c.(4066-4068)ACG>ACA	p.T1356T	CHD6_uc002xkb.1_Silent_p.T122T	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1356					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTTGACTCACCGTTTGTTTCT	0.373		NA											25	117					0	0	0	0
HNF4A	3172	broad.mit.edu	37	20	43030051	43030051	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:43030051C>T	uc002xma.2	+	1	128	c.39C>T	c.(37-39)GCC>GCT	p.A13A	HNF4A_uc010zwo.1_Intron|HNF4A_uc002xlt.2_Intron|HNF4A_uc002xlu.2_Intron|HNF4A_uc002xlv.2_Intron|uc002xlw.1_Intron|HNF4A_uc002xly.2_Silent_p.A13A|HNF4A_uc002xlz.2_Silent_p.A13A|HNF4A_uc010ggq.2_5'UTR	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	13					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TGGACATGGCCGACTACAGTG	0.637		NA											31	92					0	0	0	0
NCOA3	8202	broad.mit.edu	37	20	46264311	46264311	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:46264311C>T	uc002xtk.2	+	11	1563	c.1358C>T	c.(1357-1359)TCC>TTC	p.S453F	NCOA3_uc010ght.1_Missense_Mutation_p.S463F|NCOA3_uc002xtl.2_Missense_Mutation_p.S453F|NCOA3_uc002xtm.2_Missense_Mutation_p.S453F|NCOA3_uc002xtn.2_Missense_Mutation_p.S453F|NCOA3_uc010zyc.1_Missense_Mutation_p.S248F	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	453					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TCACCATCTTCCTACCAGAAC	0.522		NA											26	82					0	0	0	0
ADNP	23394	broad.mit.edu	37	20	49508078	49508078	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:49508078G>C	uc002xvt.1	-	5	3518	c.3173C>G	c.(3172-3174)TCT>TGT	p.S1058C	ADNP_uc002xvu.1_Missense_Mutation_p.S1058C	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	1058						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						CTGGGGGTTAGATAAGCGCTC	0.458		NA											56	194					0	0	0	0
CTCFL	140690	broad.mit.edu	37	20	56073693	56073693	+	Silent	SNP	G	G	A	rs141206026	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr20:56073693G>A	uc010gix.1	-	10	2567	c.1905C>T	c.(1903-1905)GTC>GTT	p.V635V	CTCFL_uc010giw.1_Silent_p.V635V|CTCFL_uc002xym.2_Silent_p.V635V|CTCFL_uc010giz.1_Silent_p.V223V|CTCFL_uc010giy.1_Silent_p.V305V|CTCFL_uc010gja.1_Silent_p.V585V|CTCFL_uc010gjb.1_Silent_p.V635V|CTCFL_uc010gjc.1_Silent_p.V635V|CTCFL_uc010gjd.1_Silent_p.V635V|CTCFL_uc010giu.2_RNA|CTCFL_uc010giv.2_Intron	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	635					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CTCTGCAGGCGACAGGAAACA	0.502		NA											37	101					0	0	0	0
LIPI	149998	broad.mit.edu	37	21	15525004	15525004	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr21:15525004G>A	uc002yjm.2	-	8	1081	c.1071C>T	c.(1069-1071)ACC>ACT	p.T357T		NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	336					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		CAAAATAATAGGCTACAAAAT	0.209		NA											9	22					0	0	0	0
SON	6651	broad.mit.edu	37	21	34931547	34931547	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr21:34931547G>A	uc002yse.1	+	5	6382	c.6333G>A	c.(6331-6333)CAG>CAA	p.Q2111Q	SON_uc002ysc.2_Silent_p.Q2111Q|SON_uc002ysd.2_Silent_p.Q1102Q|SON_uc002ysf.1_Silent_p.Q139Q|SON_uc002ysg.2_Silent_p.Q1102Q	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2111					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						AATGTAAACAGATCGCACAGA	0.303		NA											23	61					0	0	0	0
PCNT	5116	broad.mit.edu	37	21	47836709	47836709	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr21:47836709G>A	uc002zji.3	+	30	6984	c.6877G>A	c.(6877-6879)GAG>AAG	p.E2293K	PCNT_uc002zjj.2_Missense_Mutation_p.E2175K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2293					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding	p.E2293K(1)		ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCAGTGGGCCGAGTCTCCGCC	0.692		NA											19	19					0	0	0	0
MAPK1	5594	broad.mit.edu	37	22	22127164	22127164	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:22127164C>T	uc002zvn.2	-	7	1204	c.964G>A	c.(964-966)GAG>AAG	p.E322K	MAPK1_uc002zvo.2_Missense_Mutation_p.E322K|MAPK1_uc010gtk.1_Missense_Mutation_p.E278K	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	322					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GCTCTTACCTCGTCACTCGGG	0.478		NA											20	37					0	0	0	0
ADRBK2	157	broad.mit.edu	37	22	26083563	26083563	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:26083563T>A	uc003abx.3	+	11	1033	c.886T>A	c.(886-888)TTT>ATT	p.F296I	ADRBK2_uc010gux.2_Missense_Mutation_p.F296I|ADRBK2_uc003abw.2_Missense_Mutation_p.F183I|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	296	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GGAGATGCGGTTTTATGCCAC	0.428		NA											22	39					0	0	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30691791	30691791	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:30691791C>T	uc011akt.1	-	4	483	c.459G>A	c.(457-459)GTG>GTA	p.V153V	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Silent_p.V11V|TBC1D10A_uc003ahj.3_Silent_p.V65V|TBC1D10A_uc010gvu.2_Silent_p.V160V|TBC1D10A_uc003ahk.3_Silent_p.V153V	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	153	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CACGCTCAATCACGTCCAGCC	0.627		NA											10	28					0	0	0	0
RFPL3	10738	broad.mit.edu	37	22	32756289	32756289	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:32756289G>A	uc003amj.2	+	2	629	c.424G>A	c.(424-426)GAC>AAC	p.D142N	RFPL3_uc010gwn.2_Missense_Mutation_p.D113N|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	142	B30.2/SPRY.						zinc ion binding			ovary(1)	1						CCTCATTTCTGACGACCTCAG	0.532		NA											45	92					0	0	0	0
TNRC6B	23112	broad.mit.edu	37	22	40662468	40662468	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:40662468G>C	uc011aor.1	+	5	2445	c.2234G>C	c.(2233-2235)GGA>GCA	p.G745A	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Missense_Mutation_p.G745A|TNRC6B_uc003ayo.2_Missense_Mutation_p.G549A	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	745					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						TGGTCTTCTGGAAAGAATGGT	0.517		NA											11	27					0	0	0	0
NAGA	4668	broad.mit.edu	37	22	42461763	42461763	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:42461763C>T	uc003bbx.2	-	7	875	c.738G>A	c.(736-738)GGG>GGA	p.G246G	NAGA_uc003bby.2_Silent_p.G246G|NAGA_uc003bbw.3_Silent_p.G246G	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	246					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						CATTCCAGTGCCCAGGGCCGG	0.587		NA											14	48					0	0	0	0
MCAT	27349	broad.mit.edu	37	22	43529294	43529294	+	Missense_Mutation	SNP	C	C	T	rs144085201		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:43529294C>T	uc003bdl.1	-	4	977	c.928G>A	c.(928-930)GGG>AGG	p.G310R	MCAT_uc003bdm.1_3'UTR	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	310					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)				TGGATGTGCCCGGGATGCCTG	0.567		NA											16	150					0	0	0	0
GRAMD4	23151	broad.mit.edu	37	22	47071407	47071407	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr22:47071407G>A	uc003bhx.2	+	16	1560	c.1521G>A	c.(1519-1521)AGG>AGA	p.R507R	GRAMD4_uc010had.2_Silent_p.R446R|GRAMD4_uc003bhy.2_Silent_p.R30R	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	507	GRAM.				apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CCTCAAAGAGGAACAAAGTCA	0.552		NA											76	109					0	0	0	0
GRM7	2917	broad.mit.edu	37	3	7188201	7188201	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:7188201C>G	uc003bqm.2	+	2	856	c.582C>G	c.(580-582)TTC>TTG	p.F194L	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.F194L|GRM7_uc003bql.2_Missense_Mutation_p.F194L	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	194	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GCTATGACTTCTTCTCTCGCG	0.537		NA											44	118					0	0	0	0
BRPF1	7862	broad.mit.edu	37	3	9783100	9783100	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:9783100C>T	uc003bse.2	+	5	2230	c.1831C>T	c.(1831-1833)CGG>TGG	p.R611W	BRPF1_uc003bsf.2_Missense_Mutation_p.R611W|BRPF1_uc003bsg.2_Missense_Mutation_p.R611W|BRPF1_uc011ati.1_Missense_Mutation_p.R611W	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	611	Required for RUNX1 and RUNX2 transcriptional activation.|Interaction with MEAF6 and ING5.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GATCCGCAAGCGGGAAAAACT	0.428		NA											22	103					0	0	0	0
DLEC1	9940	broad.mit.edu	37	3	38103718	38103718	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:38103718G>C	uc003cho.1	+	4	753	c.732G>C	c.(730-732)CAG>CAC	p.Q244H	DLEC1_uc003chp.1_Missense_Mutation_p.Q244H|DLEC1_uc010hgv.1_Missense_Mutation_p.Q244H|DLEC1_uc010hgw.1_5'Flank|DLEC1_uc003chq.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	244					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTTCCGTCCAGAAGAAAGAGC	0.453		NA											29	73					0	0	0	0
SCN10A	6336	broad.mit.edu	37	3	38755460	38755460	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:38755460C>G	uc003ciq.2	-	21	3793	c.3793G>C	c.(3793-3795)GAA>CAA	p.E1265Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1265	III.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CGCATGCCTTCAAATCGAGAA	0.358		NA											32	89					0	0	0	0
SNRK	54861	broad.mit.edu	37	3	43388882	43388882	+	Silent	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:43388882C>G	uc003cms.3	+	7	1463	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L	SNRK_uc003cmt.3_Silent_p.L377L|SNRK_uc010hik.2_Silent_p.L377L|SNRK_uc011azr.1_Silent_p.L171L	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	377					myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		AGGATGACCTCACGGCCACTC	0.522		NA											26	110					0	0	0	0
TGM4	7047	broad.mit.edu	37	3	44951844	44951844	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:44951844G>A	uc003coc.3	+	11	1663	c.1590G>A	c.(1588-1590)TCG>TCA	p.S530S		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	530					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATAAGACCTCGCAGATCCAAG	0.507		NA											27	63					0	0	0	0
TEX264	51368	broad.mit.edu	37	3	51708495	51708495	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:51708495G>A	uc010hls.2	+	3	344	c.175G>A	c.(175-177)GAG>AAG	p.E59K	TEX264_uc003dbk.3_Missense_Mutation_p.E59K|TEX264_uc010hlt.2_Intron|TEX264_uc003dbl.3_Missense_Mutation_p.E59K|TEX264_uc003dbm.3_Missense_Mutation_p.E98K	NM_001129884	NP_001123356	Q9Y6I9	TX264_HUMAN	testis expressed 264 precursor	59						extracellular region					0				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		GCTCTATGGTGAGACTGGGCG	0.587		NA											33	94					0	0	0	0
GRM2	2912	broad.mit.edu	37	3	51752122	51752122	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:51752122G>A	uc010hlv.2	+	6	2852	c.2613G>A	c.(2611-2613)TCG>TCA	p.S871S	GRM2_uc003dbo.3_Silent_p.S253S|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	871	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CAACGTCATCGCTTTGAAGAC	0.582		NA											81	227					0	0	0	0
TLR9	54106	broad.mit.edu	37	3	52256442	52256442	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52256442C>G	uc003dda.1	-	2	2524	c.1890G>C	c.(1888-1890)TTG>TTC	p.L630F	TLR9_uc003ddb.2_Missense_Mutation_p.L727F	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	630	LRR 21.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CCAGCCAGATCAAACCGCTCA	0.612		NA											17	73					0	0	0	0
TLR9	54106	broad.mit.edu	37	3	52257323	52257323	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52257323G>A	uc003dda.1	-	2	1643	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C	TLR9_uc003ddb.2_Missense_Mutation_p.R434C	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	337	LRR 11.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	TTAAGCTTGCGCAGCTGTGTT	0.557		NA											43	97					0	0	0	0
DNAH1	25981	broad.mit.edu	37	3	52425293	52425293	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52425293G>C	uc011bef.1	+	62	10101	c.9840G>C	c.(9838-9840)GAG>GAC	p.E3280D	DNAH1_uc003ddv.2_Missense_Mutation_p.E138D	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3345	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTCTCCTGGAGAACGTGGGCG	0.607		NA											7	17					0	0	0	0
ITIH1	3697	broad.mit.edu	37	3	52819193	52819193	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:52819193G>A	uc003dfs.2	+	12	1565	c.1541G>A	c.(1540-1542)CGC>CAC	p.R514H	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Missense_Mutation_p.R115H|ITIH1_uc010hmo.1_Missense_Mutation_p.R68H|ITIH1_uc003dfu.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	514	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GTGGCCGGGCGCATTGCTGAC	0.572		NA											32	135					0	0	0	0
FLNB	2317	broad.mit.edu	37	3	58155432	58155432	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:58155432C>T	uc003djj.2	+	45	7698	c.7533C>T	c.(7531-7533)GAC>GAT	p.D2511D	FLNB_uc010hne.2_Silent_p.D2542D|FLNB_uc003djk.2_Silent_p.D2500D|FLNB_uc010hnf.2_Silent_p.D2487D|FLNB_uc003djl.2_Silent_p.D2331D|FLNB_uc003djm.2_Silent_p.D2318D|uc003djn.2_Intron	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2511	Interaction with INPPL1.|Filamin 24.|Self-association site, tail (By similarity).|Interaction with FLNA 2.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CATCCTCGGACGCCAGCAAGG	0.592		NA											116	84					0	0	0	0
TMF1	7110	broad.mit.edu	37	3	69088019	69088019	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:69088019G>A	uc003dnn.2	-	7	2216	c.1969C>T	c.(1969-1971)CAG>TAG	p.Q657*	TMF1_uc011bfx.1_Nonsense_Mutation_p.Q660*	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	657	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		AGGGCAGCCTGAATACTTCGG	0.353		NA											40	119					0	0	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432819	73432819	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:73432819C>T	uc003dpl.1	-	10	2994	c.2898G>A	c.(2896-2898)GAG>GAA	p.E966E	PDZRN3_uc011bgh.1_Silent_p.E623E|PDZRN3_uc010hoe.1_Silent_p.E664E|PDZRN3_uc011bgf.1_Silent_p.E683E|PDZRN3_uc011bgg.1_Silent_p.E686E	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	966							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCATCTTCATCTCGCTCACCG	0.667		NA											55	119					0	0	0	0
CNTN3	5067	broad.mit.edu	37	3	74414719	74414719	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:74414719C>T	uc003dpm.1	-	8	1161	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	361	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TACCTTACCTCTAGCACCAGG	0.498		NA											119	329					0	0	0	0
CADM2	253559	broad.mit.edu	37	3	85935436	85935436	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:85935436C>A	uc003dqj.2	+	4	1087	c.461C>A	c.(460-462)GCA>GAA	p.A154E	CADM2_uc003dqk.2_Missense_Mutation_p.A163E|CADM2_uc003dql.2_Missense_Mutation_p.A156E	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	154	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AGTAAACCTGCAGCTGATATA	0.363		NA											21	55					2.39e-15	2.57e-15	1	0
LSAMP	4045	broad.mit.edu	37	3	115805246	115805246	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:115805246C>T	uc003ebt.2	-	2	813	c.313G>A	c.(313-315)GAT>AAT	p.D105N	LSAMP_uc011bis.1_Missense_Mutation_p.D105N	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	105	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GAACCCTCATCATAGACATCC	0.498		NA											35	67					0	0	0	0
ZIC1	7545	broad.mit.edu	37	3	147127991	147127991	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:147127991G>A	uc003ewe.2	+	1	811	c.92G>A	c.(91-93)CGA>CAA	p.R31Q		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	31					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGGCCGAACGAGACGTGGGC	0.706		NA											11	38					0	0	0	0
CP	1356	broad.mit.edu	37	3	148897378	148897378	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:148897378G>A	uc003ewy.3	-	15	2879	c.2626C>T	c.(2626-2628)CCA>TCA	p.P876S	CP_uc011bnr.1_RNA|CP_uc003eww.3_Missense_Mutation_p.P28S|CP_uc003ewx.3_Missense_Mutation_p.P657S|CP_uc003ewz.2_Missense_Mutation_p.P876S	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	876	Plastocyanin-like 5.|F5/8 type A 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TAAGCCCATGGAATACAAGCA	0.373		NA											57	34					0	0	0	0
RNF13	11342	broad.mit.edu	37	3	149678787	149678787	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:149678787G>C	uc003exn.3	+	11	1826	c.1042G>C	c.(1042-1044)GAT>CAT	p.D348H	RNF13_uc003exp.3_Missense_Mutation_p.D348H|RNF13_uc010hvh.2_Missense_Mutation_p.D229H	NM_007282	NP_009213	O43567	RNF13_HUMAN	ring finger protein 13	348	Cytoplasmic (Potential).				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CGACAATGAAGATACTGACAG	0.423		NA											21	104					0	0	0	0
MED12L	116931	broad.mit.edu	37	3	150911287	150911287	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:150911287C>A	uc003eyp.2	+	14	2017	c.1979C>A	c.(1978-1980)CCT>CAT	p.P660H	MED12L_uc011bnz.1_Missense_Mutation_p.P520H|MED12L_uc003eyn.2_Missense_Mutation_p.P695H|MED12L_uc003eyo.2_Missense_Mutation_p.P660H	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	660					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTTTTTCTCCTATGCCTGGA	0.398		NA											32	80					1.31e-24	1.42e-24	1	0
MYNN	55892	broad.mit.edu	37	3	169504251	169504251	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:169504251G>C	uc003fft.2	+	8	2047	c.1618G>C	c.(1618-1620)GAA>CAA	p.E540Q	MYNN_uc011bpm.1_Missense_Mutation_p.E426Q|MYNN_uc003ffu.2_Missense_Mutation_p.E540Q|MYNN_uc003ffv.2_Missense_Mutation_p.E267Q|MYNN_uc010hwo.2_Missense_Mutation_p.E511Q	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	540						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TACTTTGAGTGAACAGGATTC	0.373		NA											59	148					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			23	85					0	0	0	0
PSMD2	5708	broad.mit.edu	37	3	184020171	184020171	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:184020171G>A	uc003fnn.1	+	6	751	c.718G>A	c.(718-720)GTG>ATG	p.V240M	PSMD2_uc011brj.1_Missense_Mutation_p.V81M|PSMD2_uc011brk.1_Missense_Mutation_p.V110M	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	240					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	TGTGAATTACGTGCCTGAGCC	0.403		NA											25	65					0	0	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043060	184043060	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:184043060C>T	uc003fnp.2	+	19	3058	c.2860C>T	c.(2860-2862)CGA>TGA	p.R954*	EIF4G1_uc003fno.1_Nonsense_Mutation_p.R895*|EIF4G1_uc010hxw.1_Nonsense_Mutation_p.R790*|EIF4G1_uc003fnt.2_Nonsense_Mutation_p.R665*|EIF4G1_uc003fnq.2_Nonsense_Mutation_p.R867*|EIF4G1_uc003fnr.2_Nonsense_Mutation_p.R790*|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.R961*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.R914*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.R961*|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.R955*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.R954*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.R961*|EIF4G1_uc003fnx.2_Nonsense_Mutation_p.R759*|EIF4G1_uc003fny.3_Nonsense_Mutation_p.R758*|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	954	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCCTAGCCCCGAATGGATCA	0.522		NA											31	109					0	0	0	0
FGFR3	2261	broad.mit.edu	37	4	1808852	1808852	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:1808852G>C	uc003gdr.3	+	18	2540	c.2284G>C	c.(2284-2286)GAC>CAC	p.D762H	FGFR3_uc003gdu.2_Missense_Mutation_p.D764H|FGFR3_uc003gds.3_Missense_Mutation_p.D650H|FGFR3_uc003gdq.3_Missense_Mutation_p.G739A	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	762	Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGAGTACCTGGACCTGTCGGC	0.701		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				3	8					0	0	0	0
FGFR3	2261	broad.mit.edu	37	4	1808924	1808924	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:1808924G>A	uc003gdr.3	+	18	2612	c.2356G>A	c.(2356-2358)GAC>AAC	p.D786N	FGFR3_uc003gdu.2_Missense_Mutation_p.D788N|FGFR3_uc003gds.3_Missense_Mutation_p.D674N|FGFR3_uc003gdq.3_Missense_Mutation_p.R763Q	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	786	Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTCAGGGGACGACTCCGTGTT	0.701		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				10	7					0	0	0	0
STIM2	57620	broad.mit.edu	37	4	27024254	27024254	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:27024254C>T	uc003gsh.3	+	13	2378	c.2162C>T	c.(2161-2163)TCA>TTA	p.S721L	STIM2_uc003gsg.3_Missense_Mutation_p.S713L|STIM2_uc010iex.2_3'UTR|STIM2_uc010iey.2_3'UTR	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	626	Cytoplasmic (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				CGAAAGATATCAAGAGATGAG	0.468		NA											49	76					0	0	0	0
TBC1D1	23216	broad.mit.edu	37	4	38117541	38117541	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:38117541G>A	uc003gtb.2	+	16	3111	c.2768G>A	c.(2767-2769)CGG>CAG	p.R923Q	TBC1D1_uc011byd.1_Missense_Mutation_p.R1017Q|TBC1D1_uc010ifd.2_Missense_Mutation_p.R710Q	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	923	Rab-GAP TBC.					nucleus	Rab GTPase activator activity			ovary(1)	1						ATGGGGCTGCGGAAACAGTAT	0.403		NA											43	45					0	0	0	0
HSD17B13	345275	broad.mit.edu	37	4	88231424	88231424	+	Silent	SNP	C	C	T	rs113762141	byFrequency	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:88231424C>T	uc003hqo.2	-	6	846	c.783G>A	c.(781-783)TCG>TCA	p.S261S	HSD17B13_uc010ikk.2_Silent_p.S225S	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	261						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TATTGATATACGATGGAACAA	0.299		NA											31	79					0	0	0	0
LARP1B	55132	broad.mit.edu	37	4	129043065	129043065	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:129043065G>A	uc003iga.2	+	11	1377	c.1246G>A	c.(1246-1248)GAT>AAT	p.D416N	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Missense_Mutation_p.D416N|LARP1B_uc003igb.1_Missense_Mutation_p.D131N	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	416							RNA binding				0						TTTTTTGTTTGATGAAGAGAT	0.333		NA											24	34					0	0	0	0
FGG	2266	broad.mit.edu	37	4	155531239	155531239	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:155531239A>T	uc003ioj.2	-	5	653	c.512T>A	c.(511-513)ATC>AAC	p.I171N	FGG_uc003iog.2_Missense_Mutation_p.I171N|FGG_uc003ioh.2_Missense_Mutation_p.I171N|FGG_uc010ipx.2_Intron|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.I171N	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	171	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GATATCATGGATTTGCACCGT	0.368		NA											63	96					0	0	0	0
NPY5R	4889	broad.mit.edu	37	4	164271506	164271506	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:164271506C>T	uc003iqn.2	+	4	263	c.81C>T	c.(79-81)TTC>TTT	p.F27F		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	27	Extracellular (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTCTGATTTCCCAGTCTGGG	0.393		NA											41	69					0	0	0	0
WDR17	116966	broad.mit.edu	37	4	177056386	177056386	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr4:177056386C>T	uc003iuj.2	+	9	1454	c.1298C>T	c.(1297-1299)CCG>CTG	p.P433L	WDR17_uc003iuk.2_Missense_Mutation_p.P409L|WDR17_uc003ium.3_Missense_Mutation_p.P409L|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	433								p.P433L(1)		ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TACACATCCCCGGGTAATGAA	0.338		NA											62	88					0	0	0	0
SLC9A3	6550	broad.mit.edu	37	5	484663	484663	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:484663C>T	uc003jbe.2	-	5	1016	c.904G>A	c.(904-906)GAG>AAG	p.E302K	SLC9A3_uc011clx.1_Missense_Mutation_p.E302K	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	302	Helical; Name=I/M7; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GACAGCATCTCGGACGTCAGG	0.632		NA											18	117					0	0	0	0
TRIO	7204	broad.mit.edu	37	5	14492748	14492748	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:14492748G>A	uc003jff.2	+	49	7711	c.7705G>A	c.(7705-7707)GAG>AAG	p.E2569K	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2569	SH3 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GAAGGAGGATGAGATCAACGT	0.532		NA											16	145					0	0	0	0
PDZD2	23037	broad.mit.edu	37	5	32108096	32108096	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:32108096G>A	uc003jhl.2	+	25	8763	c.8375G>A	c.(8374-8376)GGA>GAA	p.G2792E	PDZD2_uc003jhm.2_Missense_Mutation_p.G2792E|PDZD2_uc003jhn.2_RNA|PDZD2_uc003jho.2_RNA	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2792	PDZ 6.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GAACAAGCTGGAATAATAGAA	0.373		NA											33	231					0	0	0	0
SKP2	6502	broad.mit.edu	37	5	36181999	36181999	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:36181999G>T	uc003jkc.1	+	10	1323	c.1141G>T	c.(1141-1143)GAA>TAA	p.E381*	SKP2_uc011cou.1_Nonsense_Mutation_p.E167*|SKP2_uc003jkd.2_Intron	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	381					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACTGTTAAAGGAAGCCCTTCC	0.423		NA											86	360					9.61e-26	1.05e-25	1	0
C6	729	broad.mit.edu	37	5	41160316	41160316	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:41160316C>T	uc003jmk.2	-	11	1822	c.1612G>A	c.(1612-1614)GAA>AAA	p.E538K	C6_uc003jml.1_Missense_Mutation_p.E538K	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	538	EGF-like.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CACAGACATTCAGTCCCTGAG	0.473		NA											45	382					0	0	0	0
SNX18	112574	broad.mit.edu	37	5	53815217	53815217	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:53815217G>C	uc003jpj.3	+	1	1625	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q	SNX18_uc011cqg.1_Missense_Mutation_p.E479Q|SNX18_uc003jpi.3_Missense_Mutation_p.E479Q	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	479	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				CCAGGCCTTTGAGCTGGACCA	0.627		NA											20	33					0	0	0	0
DHX29	54505	broad.mit.edu	37	5	54585191	54585191	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:54585191C>T	uc003jpx.2	-	8	1093	c.973G>A	c.(973-975)GAA>AAA	p.E325K	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	325							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTTTTCCTTTCATTTTGTTGA	0.333		NA											23	30					0	0	0	0
SFRS12IP1	285672	broad.mit.edu	37	5	64020228	64020228	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:64020228C>T	uc003jtk.2	-	5	603	c.451G>A	c.(451-453)GAA>AAA	p.E151K		NM_173829	NP_776190	Q8N9Q2	SR1IP_HUMAN	P18SRP protein	151					mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding				0		Lung NSC(167;1.66e-05)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.119)		CTGGAGAATTCAGAACTATTA	0.199		NA											14	27					0	0	0	0
GFM2	84340	broad.mit.edu	37	5	74018254	74018254	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:74018254G>A	uc003kdh.1	-	20	2465	c.2161C>T	c.(2161-2163)CGC>TGC	p.R721C	GFM2_uc003kdi.1_Missense_Mutation_p.R674C|GFM2_uc010izj.1_Missense_Mutation_p.R753C|GFM2_uc010izk.1_RNA	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	721					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		TTGTCCTGGCGAGTCTGAATT	0.403		NA											49	106					0	0	0	0
ARSB	411	broad.mit.edu	37	5	78076243	78076243	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:78076243C>T	uc003kfq.2	-	8	2865	c.1579G>A	c.(1579-1581)GGG>AGG	p.G527R		NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	527					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		CCCCACACCCCAGTGGCCTTG	0.532		NA											41	62					0	0	0	0
GPR98	84059	broad.mit.edu	37	5	89981662	89981662	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:89981662G>A	uc003kju.2	+	29	6436	c.6340G>A	c.(6340-6342)GAT>AAT	p.D2114N	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2114	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CATTGCCAATGATGATGCATT	0.428		NA											26	32					0	0	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209500	140209500	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140209500G>A	uc003lho.2	+	1	1851	c.1824G>A	c.(1822-1824)TCG>TCA	p.S608S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.S608S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	608	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGCTTTCGTATGAGCTGC	0.657		NA											43	52					0	0	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250862	140250862	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140250862C>T	uc003lia.2	+	1	3032	c.2174C>T	c.(2173-2175)ACG>ATG	p.T725M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.T725M	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	725	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCGGCAACGCCCACTGAG	0.667		NA											24	40					0	0	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626472	140626472	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140626472G>A	uc003lje.2	+	1	1326	c.1326G>A	c.(1324-1326)TCG>TCA	p.S442S		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	442	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTGGTGTCGGACGTCAATG	0.587		NA											45	77					0	0	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720677	140720677	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:140720677G>A	uc003ljk.1	+	1	2324	c.2139G>A	c.(2137-2139)GCG>GCA	p.A713A	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Silent_p.A713A|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	713	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTGCTGGCGCACAGGCTGC	0.647		NA											42	81					0	0	0	0
TCERG1	10915	broad.mit.edu	37	5	145851051	145851051	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:145851051G>A	uc003lob.2	+	9	1553	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	TCERG1_uc003loc.2_Missense_Mutation_p.E484K|TCERG1_uc011dbt.1_Missense_Mutation_p.E484K	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	505	Glu-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTCTTGTAGGAGCCCAAAGA	0.403		NA											42	69					0	0	0	0
DCTN4	51164	broad.mit.edu	37	5	150097909	150097909	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:150097909C>G	uc003lsv.2	-	11	1102	c.1000G>C	c.(1000-1002)GAG>CAG	p.E334Q	DCTN4_uc003lsu.2_Missense_Mutation_p.E277Q|DCTN4_uc010jhi.2_Missense_Mutation_p.E341Q	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	334						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGAGGTTCTCAACTGGATTT	0.483		NA											27	45					0	0	0	0
C5orf54	63920	broad.mit.edu	37	5	159820802	159820802	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:159820802C>T	uc003lye.1	-	2	2160	c.1696G>A	c.(1696-1698)GAT>AAT	p.D566N	C5orf54_uc003lyf.1_Missense_Mutation_p.D566N	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	566										pancreas(1)	1						cggatatcatcactcagatta	0		NA											10	6					0	0	0	0
EIF4E1B	253314	broad.mit.edu	37	5	176072440	176072440	+	Silent	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:176072440C>G	uc010jkf.1	+	8	1121	c.537C>G	c.(535-537)GTC>GTG	p.V179V	TSPAN17_uc003mes.3_5'Flank|TSPAN17_uc003met.2_5'Flank|TSPAN17_uc003meu.2_5'Flank|TSPAN17_uc003mev.2_5'Flank|TSPAN17_uc003mew.2_5'Flank	NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	179					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGCCGTCGTCAACATCCGCA	0.622		NA											19	38					0	0	0	0
ZNF354C	30832	broad.mit.edu	37	5	178505983	178505983	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr5:178505983G>C	uc003mju.2	+	5	665	c.550G>C	c.(550-552)GAA>CAA	p.E184Q		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TGTTCCTATAGAAAGGATACC	0.353		NA											32	69					0	0	0	0
FARS2	10667	broad.mit.edu	37	6	5368981	5368981	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:5368981C>T	uc010jnv.1	+	2	514	c.178C>T	c.(178-180)CAG>TAG	p.Q60*	FARS2_uc003mwr.2_Nonsense_Mutation_p.Q60*|FARS2_uc003mws.1_Nonsense_Mutation_p.Q60*	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	60					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	ATCCTACCCTCAGGACGACCA	0.612		NA											29	48					0	0	0	0
GNL1	2794	broad.mit.edu	37	6	30523396	30523396	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:30523396G>A	uc003nqh.2	-	2	1203	c.175C>T	c.(175-177)CAT>TAT	p.H59Y	GNL1_uc011dmi.1_5'UTR|GNL1_uc011dmj.1_Missense_Mutation_p.H57Y|GNL1_uc011dmk.1_Intron|PRR3_uc003nqi.1_5'Flank|PRR3_uc003nqj.1_5'Flank	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	59					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						CTGCGGATATGATGGGTCACA	0.657		NA											46	96					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38891905	38891905	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:38891905G>A	uc003ooe.1	+	71	10878	c.10278G>A	c.(10276-10278)CTG>CTA	p.L3426L	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAGAAAACCTGAATCTTATTT	0.348		NA											30	90					0	0	0	0
PGC	5225	broad.mit.edu	37	6	41712219	41712219	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:41712219G>A	uc003ora.1	-	3	293	c.244C>T	c.(244-246)CCA>TCA	p.P82S		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	82					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TTCTGGGGTGGAGTCCCGATG	0.617		NA											33	105					0	0	0	0
PLA2G7	7941	broad.mit.edu	37	6	46678347	46678347	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:46678347C>G	uc010jzf.2	-	8	981	c.712G>C	c.(712-714)GAC>CAC	p.D238H	PLA2G7_uc010jzg.1_Missense_Mutation_p.D238H|PLA2G7_uc011dwd.1_Missense_Mutation_p.D193H|PLA2G7_uc011dwe.1_Missense_Mutation_p.D111H	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	238					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			TGATCAATGTCAAGAATCAGA	0.323		NA											54	125					0	0	0	0
PKHD1	5314	broad.mit.edu	37	6	51612959	51612959	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:51612959T>G	uc003pah.1	-	58	9731	c.9455A>C	c.(9454-9456)AAC>ACC	p.N3152T	PKHD1_uc010jzn.1_Missense_Mutation_p.N1135T|PKHD1_uc003pai.2_Missense_Mutation_p.N3152T	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3152	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ATAGTCAAAGTTCTTGAAAGC	0.418		NA											9	413					0	0	0	0
COL19A1	1310	broad.mit.edu	37	6	70840095	70840095	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:70840095G>A	uc003pfc.1	+	18	1480	c.1363G>A	c.(1363-1365)GGA>AGA	p.G455R	COL19A1_uc010kam.1_Missense_Mutation_p.G351R	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	455	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ACATGAAGCTGGAGGCCTGAA	0.224		NA											5	55					0	0	0	0
DDX43	55510	broad.mit.edu	37	6	74104684	74104684	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:74104684G>A	uc003pgw.2	+	1	400	c.56G>A	c.(55-57)CGA>CAA	p.R19Q	OOEP_uc003pgv.3_5'UTR|DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	19						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						GCTAGTCGGCGAAGCTCGACA	0.627		NA											49	81					0	0	0	0
IBTK	25998	broad.mit.edu	37	6	82935280	82935280	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:82935280C>T	uc003pjl.1	-	6	1266	c.739G>A	c.(739-741)GAT>AAT	p.D247N	IBTK_uc011dyv.1_Missense_Mutation_p.D247N|IBTK_uc011dyw.1_Missense_Mutation_p.D247N|IBTK_uc010kbi.1_5'UTR|IBTK_uc003pjm.2_Missense_Mutation_p.D247N	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	247					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		ACACATCCATCTTCAGTTAAT	0.383		NA											23	74					0	0	0	0
LACE1	246269	broad.mit.edu	37	6	108843519	108843519	+	Missense_Mutation	SNP	C	C	A	rs149085596	by1000genomes	TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:108843519C>A	uc003psj.2	+	13	1523	c.1337C>A	c.(1336-1338)TCC>TAC	p.S446Y		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	446							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		GAAGGACTCTCCATGTTTACC	0.368		NA											4	103					0.00024832	0.000257517	1	0
C6orf182	285753	broad.mit.edu	37	6	109480484	109480484	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:109480484C>T	uc010kdk.2	+	11	1412	c.835C>T	c.(835-837)CGT>TGT	p.R279C	C6orf182_uc003psx.3_Missense_Mutation_p.R279C|C6orf182_uc010kdl.2_Missense_Mutation_p.R279C|C6orf182_uc003psy.3_Missense_Mutation_p.R279C	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753	279						microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		GAGGCAACATCGTGACCCACA	0.403		NA											47	108					0	0	0	0
FAM184A	79632	broad.mit.edu	37	6	119338003	119338003	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:119338003G>A	uc003pyj.2	-	5	1787	c.1439C>T	c.(1438-1440)TCT>TTT	p.S480F	FAM184A_uc003pyk.3_Missense_Mutation_p.S360F|FAM184A_uc003pyl.3_Missense_Mutation_p.S360F	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	480	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CAAAGTCTTAGAATGGGCCTC	0.378		NA											47	113					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152456262	152456262	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:152456262G>A	uc010kiw.2	-	142	26367	c.25765C>T	c.(25765-25767)CAG>TAG	p.Q8589*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.Q3113*|SYNE1_uc003qos.3_Nonsense_Mutation_p.Q3113*|SYNE1_uc003qot.3_Nonsense_Mutation_p.Q8541*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q8589*|SYNE1_uc003qop.3_Nonsense_Mutation_p.Q774*|SYNE1_uc011eez.1_Nonsense_Mutation_p.Q791*|SYNE1_uc003qoq.3_Nonsense_Mutation_p.Q791*|SYNE1_uc003qor.3_Nonsense_Mutation_p.Q1512*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8589	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGATGGTCCTGAAGTATCTCT	0.383		NA								HNSCC(10;0.0054)			21	86					0	0	0	0
ARID1B	57492	broad.mit.edu	37	6	157527778	157527778	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:157527778G>A	uc003qqn.2	+	20	5601	c.5449G>A	c.(5449-5451)GAG>AAG	p.E1817K	ARID1B_uc003qqo.2_Missense_Mutation_p.E1777K|ARID1B_uc003qqp.2_Missense_Mutation_p.E1764K	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1822					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GACTCACTTTGAGAGCAAGAT	0.567		NA											37	188					0	0	0	0
INTS1	26173	broad.mit.edu	37	7	1542722	1542722	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:1542722G>A	uc003skn.2	-	3	265	c.164C>T	c.(163-165)TCT>TTT	p.S55F	INTS1_uc003skq.2_Missense_Mutation_p.S55F	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	55					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTTGCGCTCAGAAGGCAGGCC	0.647		NA											25	55					0	0	0	0
HDAC9	9734	broad.mit.edu	37	7	18806740	18806740	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:18806740C>T	uc003suh.2	+	15	2208	c.2167C>T	c.(2167-2169)CAA>TAA	p.Q723*	HDAC9_uc003sue.2_Nonsense_Mutation_p.Q723*|HDAC9_uc011jyd.1_Nonsense_Mutation_p.Q723*|HDAC9_uc003sui.2_Nonsense_Mutation_p.Q726*|HDAC9_uc003suj.2_Nonsense_Mutation_p.Q682*|HDAC9_uc003sua.1_Nonsense_Mutation_p.Q701*	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	723	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGATGACTCTCAAAAGTTTTT	0.264		NA											5	19					0	0	0	0
CPVL	54504	broad.mit.edu	37	7	29132252	29132252	+	Silent	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:29132252G>T	uc003szv.2	-	6	648	c.529C>A	c.(529-531)CGG>AGG	p.R177R	CPVL_uc003szw.2_Silent_p.R177R|CPVL_uc003szx.2_Silent_p.R177R	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	177					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TATAAATCCCGTGCTACATCG	0.398		NA											62	14					2.54e-27	2.78e-27	1	0
GARS	2617	broad.mit.edu	37	7	30639566	30639566	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:30639566C>T	uc003tbm.2	+	3	685	c.328C>T	c.(328-330)CTG>TTG	p.L110L		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	110	WHEP-TRS.				cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	CTAACAGGAGCTGGCGTTACA	0.383		NA											45	101					0	0	0	0
SFRP4	6424	broad.mit.edu	37	7	37955895	37955895	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:37955895G>A	uc003tfo.3	-	1	631	c.245C>T	c.(244-246)GCG>GTG	p.A82V		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	82	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						GCAAATGGGCGCGTACATGGC	0.622		NA											59	34					0	0	0	0
VPS41	27072	broad.mit.edu	37	7	38812186	38812186	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:38812186A>G	uc003tgy.2	-	13	1090	c.1064T>C	c.(1063-1065)GTA>GCA	p.V355A	VPS41_uc003tgz.2_Missense_Mutation_p.V330A|VPS41_uc010kxn.2_Missense_Mutation_p.V266A	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	355					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CTTGGCCACTACAACATCTCT	0.408		NA											25	53					0	0	0	0
CALN1	83698	broad.mit.edu	37	7	71252799	71252799	+	Silent	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:71252799C>G	uc003twa.3	-	6	1148	c.621G>C	c.(619-621)CTG>CTC	p.L207L	CALN1_uc003twb.3_Silent_p.L249L|CALN1_uc003twc.3_Silent_p.L207L	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	207	Helical; Anchor for type IV membrane protein; (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TGGCTGCAATCAGCATGACAC	0.592		NA											25	51					0	0	0	0
MAGI2	9863	broad.mit.edu	37	7	77797320	77797320	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:77797320T>G	uc003ugx.2	-	15	2763	c.2509A>C	c.(2509-2511)ACC>CCC	p.T837P	MAGI2_uc003ugy.2_Missense_Mutation_p.T823P|MAGI2_uc010ldx.1_Missense_Mutation_p.T430P	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	837	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TAGCGGTGGGTTTTGCCGGCT	0.552		NA											175	77					0	0	0	0
MAGI2	9863	broad.mit.edu	37	7	78131061	78131061	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:78131061C>T	uc003ugx.2	-	5	1052	c.798G>A	c.(796-798)GAG>GAA	p.E266E	MAGI2_uc003ugy.2_Silent_p.E266E|MAGI2_uc011kgr.1_Silent_p.E98E|MAGI2_uc011kgs.1_Silent_p.E103E	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	266	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGGAGGGCATCTCCCCTGAGG	0.498		NA											38	73					0	0	0	0
SEMA3C	10512	broad.mit.edu	37	7	80546041	80546041	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:80546041C>T	uc003uhj.2	-	2	619	c.57G>A	c.(55-57)GTG>GTA	p.V19V	SEMA3C_uc011kgw.1_Silent_p.V37V|SEMA3C_uc011kgx.1_5'UTR	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	19					immune response|response to drug	membrane	receptor activity			ovary(1)	1						AAGATCCTTTCACACAGATAG	0.343		NA											40	128					0	0	0	0
PDK4	5166	broad.mit.edu	37	7	95215081	95215081	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:95215081C>T	uc003uoa.2	-	11	1428	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K	PDK4_uc003unz.2_Missense_Mutation_p.E158K	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	370					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			TCTATAGACTCAGAAGACAAA	0.378		NA											19	63					0	0	0	0
LMTK2	22853	broad.mit.edu	37	7	97820093	97820093	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:97820093C>T	uc003upd.1	+	10	1345	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	351	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CAGCCGTATTCAAACCTTTCC	0.468		NA											223	170					0	0	0	0
PLOD3	8985	broad.mit.edu	37	7	100859192	100859192	+	Silent	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:100859192C>G	uc003uyd.2	-	5	1068	c.612G>C	c.(610-612)CTG>CTC	p.L204L	ZNHIT1_uc003uye.2_5'Flank|ZNHIT1_uc003uyf.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	204					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	TCCCTACCCTCAGTCCTGGGT	0.582		NA											13	64					0	0	0	0
PSMC2	5701	broad.mit.edu	37	7	102996211	102996211	+	Silent	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:102996211C>G	uc003vbs.2	+	4	331	c.261C>G	c.(259-261)CTC>CTG	p.L87L	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011kln.1_Silent_p.L87L|PSMC2_uc011klo.1_Intron	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	87					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						AGCAGACACTCCAGAGTGAAC	0.458		NA											21	35					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103130201	103130201	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:103130201C>T	uc003vca.2	-	60	9911	c.9751G>A	c.(9751-9753)GAG>AAG	p.E3251K	RELN_uc010liz.2_Missense_Mutation_p.E3251K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3251	EGF-like 8.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGGAAGCTCTCGTCGCAGATG	0.403		NA											10	33					0	0	0	0
RELN	5649	broad.mit.edu	37	7	103389927	103389927	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:103389927A>G	uc003vca.2	-	6	762	c.602T>C	c.(601-603)ATC>ACC	p.I201T	RELN_uc010liz.2_Missense_Mutation_p.I201T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	201					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATCTCTCAGGATAATGCTGTC	0.343		NA											105	78					0	0	0	0
AKR1B1	231	broad.mit.edu	37	7	134134473	134134473	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:134134473G>A	uc003vrp.1	-	4	502	c.428C>T	c.(427-429)GCG>GTG	p.A143V	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	143					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	CTGTCTTACCGCCCACGTGTC	0.458		NA											158	103					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151896385	151896385	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:151896385G>C	uc003wla.2	-	27	4471	c.4252C>G	c.(4252-4254)CCA>GCA	p.P1418A	MLL3_uc003wkz.2_Missense_Mutation_p.P479A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1418					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GATTTTGTTGGAGCCGAGGAT	0.333		NA	N		medulloblastoma								21	58					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151896520	151896520	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:151896520G>C	uc003wla.2	-	27	4336	c.4117C>G	c.(4117-4119)CTA>GTA	p.L1373V	MLL3_uc003wkz.2_Missense_Mutation_p.L434V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1373					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTTGTATCTAGAAGATCTTTT	0.318		NA	N		medulloblastoma								29	69					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154595624	154595624	+	Silent	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr7:154595624C>T	uc003wlk.2	+	14	1587	c.1458C>T	c.(1456-1458)GAC>GAT	p.D486D	DPP6_uc003wli.2_Silent_p.D422D|DPP6_uc003wlm.2_Silent_p.D424D|DPP6_uc011kvq.1_Silent_p.D379D	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	486	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GGGACTGGGACGTGACCAAGA	0.557		NA											7	30					0	0	0	0
MYOM2	9172	broad.mit.edu	37	8	2054178	2054178	+	Missense_Mutation	SNP	G	G	T	rs140995511		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:2054178G>T	uc003wpx.3	+	22	3019	c.2881G>T	c.(2881-2883)GTG>TTG	p.V961L	MYOM2_uc011kwi.1_Missense_Mutation_p.V386L	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	961	Ig-like C2-type 3.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AATCGAAACCGTGGGGGATCA	0.448		NA											16	95					7.26e-15	7.79e-15	1	0
TNKS	8658	broad.mit.edu	37	8	9437728	9437728	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:9437728C>T	uc003wss.2	+	2	738	c.733C>T	c.(733-735)CGT>TGT	p.R245C	TNKS_uc011kwv.1_Missense_Mutation_p.R245C|TNKS_uc011kww.1_Missense_Mutation_p.R8C	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	245	ANK 1.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		TGTCCACGCTCGTGATGATGG	0.418		NA											69	193					0	0	0	0
TM2D2	83877	broad.mit.edu	37	8	38851142	38851142	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:38851142G>A	uc003xmk.2	-	3	436	c.353C>T	c.(352-354)TCA>TTA	p.S118L	TM2D2_uc003xml.2_Missense_Mutation_p.S75L|TM2D2_uc003xmm.2_Missense_Mutation_p.S75L|TM2D2_uc003xmn.2_Missense_Mutation_p.S75L	NM_078473	NP_510882	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2 isoform a	118						integral to membrane					0		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GCACTGGACTGAAGTGTGTTC	0.448		NA											26	56					0	0	0	0
PRDM14	63978	broad.mit.edu	37	8	70981882	70981882	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:70981882G>A	uc003xym.2	-	2	416	c.214C>T	c.(214-216)CGG>TGG	p.R72W		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	72					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GGCGCCATCCGGAAGGGGAAG	0.652		NA											7	10					0	0	0	0
HNF4G	3174	broad.mit.edu	37	8	76465281	76465281	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:76465281C>T	uc003yaq.2	+	6	623	c.353C>T	c.(352-354)TCA>TTA	p.S118L	HNF4G_uc003yar.2_Missense_Mutation_p.S155L	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	118					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TACTAGATCTCAGTCTCAAGC	0.348		NA											25	63					0	0	0	0
HNF4G	3174	broad.mit.edu	37	8	76471076	76471076	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:76471076G>A	uc003yaq.2	+	9	1056	c.786G>A	c.(784-786)ATG>ATA	p.M262I	HNF4G_uc003yar.2_Missense_Mutation_p.M299I	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	262					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TTAAGAACATGAGGTTCCAAG	0.453		NA											36	71					0	0	0	0
RIMS2	9699	broad.mit.edu	37	8	105105807	105105807	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:105105807C>T	uc003yls.2	+	21	3071	c.2830C>T	c.(2830-2832)CGT>TGT	p.R944C	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.R1017C|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	398					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TAGTGCTTCTCGTTTCAGCAG	0.423		NA								HNSCC(12;0.0054)			42	111					0	0	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110401306	110401306	+	Splice_Site	SNP	A	A	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:110401306A>T	uc003yne.2	+	8	728	c.624_splice	c.e8-2	p.L208_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTTTTAATTAGATATGGTCT	0.294		NA								HNSCC(38;0.096)			43	94					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113519017	113519017	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:113519017G>A	uc003ynu.2	-	29	4957	c.4798C>T	c.(4798-4800)CTT>TTT	p.L1600F	CSMD3_uc003yns.2_Missense_Mutation_p.L872F|CSMD3_uc003ynt.2_Missense_Mutation_p.L1560F|CSMD3_uc011lhx.1_Missense_Mutation_p.L1496F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1600	Extracellular (Potential).|CUB 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTGGTGAAAGAATAAAGCCT	0.378		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	76					0	0	0	0
FER1L6	654463	broad.mit.edu	37	8	125076810	125076810	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:125076810C>T	uc003yqw.2	+	26	3757	c.3551C>T	c.(3550-3552)CCT>CTT	p.P1184L	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1184	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GATGGAAAACCTAAGGTCAGA	0.453		NA											18	52					0	0	0	0
DOCK8	81704	broad.mit.edu	37	9	390558	390558	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:390558G>C	uc003zgf.2	+	24	3074	c.2962G>C	c.(2962-2964)GAG>CAG	p.E988Q	DOCK8_uc010mgu.2_Missense_Mutation_p.E290Q|DOCK8_uc010mgv.2_Missense_Mutation_p.E888Q|DOCK8_uc010mgw.1_Missense_Mutation_p.E290Q|DOCK8_uc003zgk.2_Missense_Mutation_p.E446Q	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	988					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GTTCTTCTTTGAGCTTCTGGT	0.433		NA											24	83					0	0	0	0
GLIS3	169792	broad.mit.edu	37	9	4118651	4118651	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:4118651G>A	uc003zhw.1	-	3	556	c.362C>T	c.(361-363)ACG>ATG	p.T121M	GLIS3_uc003zhx.1_Missense_Mutation_p.T276M|GLIS3_uc003zic.1_Missense_Mutation_p.T276M|GLIS3_uc003zie.1_Missense_Mutation_p.T276M|GLIS3_uc010mhh.1_Missense_Mutation_p.T151M|GLIS3_uc003zid.1_Missense_Mutation_p.T54M|GLIS3_uc010mhi.1_Missense_Mutation_p.T83M|GLIS3_uc003zif.1_Missense_Mutation_p.T54M|GLIS3_uc003zig.1_Missense_Mutation_p.T120M|GLIS3_uc003zih.1_Missense_Mutation_p.T54M|GLIS3_uc003zhy.1_Missense_Mutation_p.T54M|GLIS3_uc003zhz.1_Missense_Mutation_p.T54M|GLIS3_uc003zib.1_Missense_Mutation_p.T120M|GLIS3_uc010mhg.1_Missense_Mutation_p.T54M	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	121	Ser-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCTACTTTCCGTGCCAAAAAG	0.557		NA											43	108					0	0	0	0
UHRF2	115426	broad.mit.edu	37	9	6460620	6460620	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:6460620C>T	uc003zjy.2	+	4	1032	c.692C>T	c.(691-693)CCA>CTA	p.P231L	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zka.1_Missense_Mutation_p.P8L	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	231	Interaction with PCNP.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		GATCTTAGACCACGAGCTAGA	0.368		NA											39	113					0	0	0	0
UHRF2	115426	broad.mit.edu	37	9	6506129	6506129	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:6506129C>G	uc003zjy.2	+	16	2699	c.2359C>G	c.(2359-2361)CTG>GTG	p.L787V	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zkb.2_RNA	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	787					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		CAATGAGATTCTGCAGACTCT	0.468		NA											43	117					0	0	0	0
C9orf150	286343	broad.mit.edu	37	9	12821667	12821667	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:12821667T>G	uc003zkw.2	+	2	1298	c.595T>G	c.(595-597)TTG>GTG	p.L199V		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	hypothetical protein LOC286343	202											0				GBM - Glioblastoma multiforme(1;1.64e-13)		CCCTTCAGACTTGGACCAATT	0.512		NA											55	142					0	0	0	0
BNC2	54796	broad.mit.edu	37	9	16436303	16436303	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:16436303T>A	uc003zml.2	-	6	2029	c.1889A>T	c.(1888-1890)AAG>ATG	p.K630M	BNC2_uc011lmw.1_Missense_Mutation_p.K535M|BNC2_uc003zmm.2_Missense_Mutation_p.K588M|BNC2_uc003zmq.1_Missense_Mutation_p.K644M|BNC2_uc003zmr.1_Missense_Mutation_p.K667M|BNC2_uc003zmp.1_Missense_Mutation_p.K658M|BNC2_uc010mij.1_Missense_Mutation_p.K552M|BNC2_uc011lmv.1_Missense_Mutation_p.K456M|BNC2_uc003zmo.1_Missense_Mutation_p.K552M|BNC2_uc003zmj.2_Missense_Mutation_p.K395M|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.K395M|BNC2_uc003zmn.1_Missense_Mutation_p.K395M	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	630				K -> T (in Ref. 1; BAC03837).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GGGCTTTTTCTTGGGTGCCAG	0.527		NA											40	88					0	0	0	0
DCAF12	25853	broad.mit.edu	37	9	34107477	34107477	+	Silent	SNP	G	G	C			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:34107477G>C	uc003ztt.2	-	3	762	c.420C>G	c.(418-420)GGC>GGG	p.G140G		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	140	WD 1.					centrosome|CUL4 RING ubiquitin ligase complex					0						GGATACCACAGCCCTGCTGGG	0.512		NA											67	44					0	0	0	0
PAX5	5079	broad.mit.edu	37	9	37015106	37015106	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:37015106C>T	uc003zzo.1	-	3	746	c.298G>A	c.(298-300)GCT>ACT	p.A100T	PAX5_uc011lpw.1_Missense_Mutation_p.A100T|PAX5_uc011lpx.1_Intron|PAX5_uc011lpy.1_5'UTR|PAX5_uc010mls.1_Missense_Mutation_p.A100T|PAX5_uc011lpz.1_Missense_Mutation_p.A100T|PAX5_uc011lqa.1_5'UTR|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.A100T|PAX5_uc010mlp.1_Missense_Mutation_p.A100T|PAX5_uc011lqc.1_Missense_Mutation_p.A100T|PAX5_uc010mlr.1_Missense_Mutation_p.A100T|PAX5_uc011lqd.1_Intron|PAX5_uc011lqe.1_RNA|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_RNA	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	100	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(32)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		TTATATTCAGCGATTTTTTCC	0.522		NA	T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								138	315					0	0	0	0
APBA1	320	broad.mit.edu	37	9	72131087	72131087	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:72131087G>A	uc004ahh.2	-	2	1316	c.1040C>T	c.(1039-1041)TCG>TTG	p.S347L		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	347					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GATGGCCAGCGAGATGGCATC	0.398		NA											32	76					0	0	0	0
TRPM6	140803	broad.mit.edu	37	9	77448916	77448916	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:77448916C>A	uc004ajl.1	-	6	905	c.667G>T	c.(667-669)GAT>TAT	p.D223Y	TRPM6_uc004ajk.1_Missense_Mutation_p.D218Y|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.D223Y|TRPM6_uc010mpd.1_Missense_Mutation_p.D223Y|TRPM6_uc010mpe.1_Missense_Mutation_p.D223Y|TRPM6_uc004ajn.1_Missense_Mutation_p.D223Y	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	223	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CTACTTACATCTTTTCCAATA	0.313		NA											71	54					1.02e-41	1.12e-41	1	0
FLJ46321	389763	broad.mit.edu	37	9	84609179	84609179	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:84609179G>A	uc004amn.2	+	4	3841	c.3794G>A	c.(3793-3795)CGT>CAT	p.R1265H		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1265						integral to membrane					0						AGCGGAATCCGTGTGGCACAG	0.527		NA											92	176					0	0	0	0
RASEF	158158	broad.mit.edu	37	9	85627423	85627423	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:85627423C>T	uc004amo.1	-	5	1030	c.769G>A	c.(769-771)GAA>AAA	p.E257K		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	257	Potential.				protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						GATTGTTCTTCGAGCTGAAAG	0.323		NA											11	28					0	0	0	0
FAM22F	54754	broad.mit.edu	37	9	97082865	97082865	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:97082865G>A	uc004aup.1	-	5	1014	c.993C>T	c.(991-993)CCC>CCT	p.P331P		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	331	Pro-rich.										0		Acute lymphoblastic leukemia(62;0.136)				CATCCTTGCTGGGAAGGTACA	0.687		NA											5	12					0	0	0	0
C9orf84	158401	broad.mit.edu	37	9	114454011	114454011	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:114454011C>T	uc004bfr.2	-	25	4189	c.4054G>A	c.(4054-4056)GAG>AAG	p.E1352K	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.E1313K|C9orf84_uc010mug.2_Missense_Mutation_p.E1263K	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	1352										ovary(2)	2						CAGAAAGTCTCATCTTTTGAA	0.348		NA											38	110					0	0	0	0
STRBP	55342	broad.mit.edu	37	9	125921433	125921433	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:125921433G>A	uc004bns.2	-	9	1207	c.777C>T	c.(775-777)GGC>GGT	p.G259G	STRBP_uc004bnt.2_Silent_p.G77G|STRBP_uc004bnu.2_Silent_p.G245G|STRBP_uc004bnv.2_Silent_p.G259G	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	259	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						CCTCCCCAGCGCCCAAAGGTC	0.393		NA											41	98					0	0	0	0
ASB6	140459	broad.mit.edu	37	9	132401583	132401583	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:132401583C>T	uc004byf.1	-	4	575	c.409G>A	c.(409-411)GAG>AAG	p.E137K	ASB6_uc004bye.1_Missense_Mutation_p.E62K|ASB6_uc004byg.1_Intron|ASB6_uc011mbt.1_Missense_Mutation_p.E58K|ASB6_uc010myx.1_Missense_Mutation_p.E137K	NM_017873	NP_060343	Q9NWX5	ASB6_HUMAN	ankyrin repeat and SOCS box-containing 6 isoform	137	ANK 3.				intracellular signal transduction	cytoplasm					0		Ovarian(14;0.00556)				GGGCTACTCTCGTGGATCTGA	0.632		NA											33	75					0	0	0	0
GPR107	57720	broad.mit.edu	37	9	132890983	132890983	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:132890983C>T	uc004bze.2	+	19	1876	c.1649C>T	c.(1648-1650)TCA>TTA	p.S550L	GPR107_uc004bzb.2_Missense_Mutation_p.S313L|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.S521L|GPR107_uc004bzd.2_Missense_Mutation_p.S502L|GPR107_uc004bzg.1_5'Flank	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	550						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CGTCCGGCTTCAGATAACCCC	0.448		NA											66	213					0	0	0	0
DBH	1621	broad.mit.edu	37	9	136518063	136518063	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:136518063G>A	uc004cel.2	+	9	1385	c.1376G>A	c.(1375-1377)GGA>GAA	p.G459E		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	459	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TTTCCTCAGGGAGATGTGCTC	0.632		NA											30	61					0	0	0	0
SNAPC4	6621	broad.mit.edu	37	9	139278482	139278482	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr9:139278482G>A	uc004chh.2	-	14	1432	c.1423C>T	c.(1423-1425)CAC>TAC	p.H475Y		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	475	HTH myb-type 3.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		TTTGCCCAGTGACCTGCAAAA	0.552		NA											15	40					0	0	0	0
GYG2	8908	broad.mit.edu	37	X	2773149	2773149	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:2773149C>T	uc004cqs.1	+	6	815	c.533C>T	c.(532-534)ACG>ATG	p.T178M	GYG2_uc004cqt.1_Missense_Mutation_p.T147M|GYG2_uc004cqu.1_Missense_Mutation_p.T147M|GYG2_uc004cqv.1_Translation_Start_Site|GYG2_uc004cqw.1_Missense_Mutation_p.T138M|GYG2_uc004cqx.1_Missense_Mutation_p.T147M|GYG2_uc010ndc.1_Translation_Start_Site	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	178					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTCTCCACACGCATAAACTC	0.502		NA											54	160					0	0	0	0
ARSF	416	broad.mit.edu	37	X	3002413	3002413	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:3002413G>A	uc004cre.1	+	6	757	c.536G>A	c.(535-537)CGT>CAT	p.R179H	ARSF_uc004crf.1_Missense_Mutation_p.R179H	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	179						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GACCCCTCTCGTAACACGGAA	0.537		NA											52	113					0	0	0	0
STS	412	broad.mit.edu	37	X	7268021	7268021	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:7268021G>A	uc004cry.3	+	10	1716	c.1471G>A	c.(1471-1473)GGG>AGG	p.G491R		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	491	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CTTCTGTTTCGGGAGTTATGT	0.507		NA							Ichthyosis				55	142					0	0	0	0
HCCS	3052	broad.mit.edu	37	X	11135450	11135450	+	Missense_Mutation	SNP	G	G	C	rs144634482		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:11135450G>C	uc004cuk.2	+	4	582	c.316G>C	c.(316-318)GAG>CAG	p.E106Q	HCCS_uc004cuj.2_Missense_Mutation_p.E106Q|HCCS_uc004cul.1_Missense_Mutation_p.E106Q	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	106					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						TGTCAGAGAAGAGTCATCCAT	0.393		NA											72	172					0	0	0	0
BMX	660	broad.mit.edu	37	X	15555263	15555263	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:15555263G>T	uc004cww.2	+	14	1417	c.1229G>T	c.(1228-1230)TGG>TTG	p.W410L	BMX_uc004cwx.3_Missense_Mutation_p.W410L|BMX_uc004cwy.3_Missense_Mutation_p.W410L	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	410					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					TTAGGAATCTGGGAACTGAAA	0.483		NA											91	271					9.25e-40	1.01e-39	1	0
SH3KBP1	30011	broad.mit.edu	37	X	19702076	19702076	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:19702076G>A	uc004czm.2	-	6	907	c.591C>T	c.(589-591)AAC>AAT	p.N197N	SH3KBP1_uc004czl.2_Silent_p.N160N	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	197					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						CCACTGTCCCGTTGGCACCTT	0.507		NA											65	167					0	0	0	0
OTC	5009	broad.mit.edu	37	X	38262913	38262913	+	Missense_Mutation	SNP	G	G	A	rs67294956		TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:38262913G>A	uc004def.3	+	6	797	c.583G>A	c.(583-585)GGG>AGG	p.G195R		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	195			G -> R (in OTCD; no activity).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	CAGCTGGATCGGGGATGGGAA	0.478		NA											43	91					0	0	0	0
PPP1R3F	89801	broad.mit.edu	37	X	49142813	49142813	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:49142813C>T	uc004dnh.1	+	4	1677	c.1661C>T	c.(1660-1662)ACG>ATG	p.T554M	PPP1R3F_uc011mnd.1_Missense_Mutation_p.T225M|PPP1R3F_uc004dni.2_Missense_Mutation_p.T208M|PPP1R3F_uc004dnj.1_Missense_Mutation_p.T208M	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	554	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					GAGGAGATCACGCTGCACTAT	0.647		NA											16	39					0	0	0	0
KDM5C	8242	broad.mit.edu	37	X	53243984	53243984	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:53243984C>T	uc004drz.2	-	8	1542	c.1009G>A	c.(1009-1011)GAC>AAC	p.D337N	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.D270N|KDM5C_uc004dsa.2_Missense_Mutation_p.D336N	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	337	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						AGGAGCTTGTCATCCTCATCC	0.537		NA	N|F|S		clear cell renal carcinoma								22	38					0	0	0	0
HUWE1	10075	broad.mit.edu	37	X	53573555	53573555	+	Splice_Site	SNP	T	T	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:53573555T>A	uc004dsp.2	-	70	11161	c.10759_splice	c.e70-1	p.V3587_splice	HUWE1_uc004dsn.2_Splice_Site_p.V2395_splice|HUWE1_uc004dsq.1_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1						base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TGTCAACACCTGAGAAAAAGA	0.502		NA											24	27					0	0	0	0
IGBP1	3476	broad.mit.edu	37	X	69385733	69385733	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:69385733G>A	uc004dxv.2	+	6	1421	c.922G>A	c.(922-924)GAA>AAA	p.E308K	IGBP1_uc004dxw.2_Missense_Mutation_p.E308K	NM_001551	NP_001542	P78318	IGBP1_HUMAN	immunoglobulin binding protein 1	308					B cell activation|negative regulation of caspase activity|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|regulation of microtubule-based movement|response to interleukin-1|response to tumor necrosis factor|signal transduction	cytoplasm	protein phosphatase type 2A regulator activity			kidney(1)|pancreas(1)	2						AGAAAAGGAGGAAGAGGATGA	0.468		NA											17	41					0	0	0	0
KIF4A	24137	broad.mit.edu	37	X	69595998	69595998	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:69595998G>A	uc004dyg.2	+	18	2099	c.1972G>A	c.(1972-1974)GCT>ACT	p.A658T	KIF4A_uc010nkw.2_Missense_Mutation_p.A658T|KIF4A_uc004dyf.1_Missense_Mutation_p.A658T	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	658	Potential.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						GAAAGAAGATGCTGAGAAGTT	0.338		NA											21	58					0	0	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83361414	83361414	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:83361414G>A	uc004eej.1	-	15	1401	c.1324C>T	c.(1324-1326)CGA>TGA	p.R442*	RPS6KA6_uc011mqt.1_Nonsense_Mutation_p.R442*|RPS6KA6_uc011mqu.1_Nonsense_Mutation_p.R339*	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	442	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TGTATGCATCGCTTGCAAACA	0.348		NA											10	34					0	0	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249462	119249462	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:119249462C>T	uc004esk.1	-	1	386	c.311G>A	c.(310-312)CGA>CAA	p.R104Q	uc004esi.1_Intron	NM_139282	NP_644811	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	104	Homeobox.				gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCGCCGAGTTCGTGGCTGCAT	0.652		NA											31	101					0	0	0	0
FRMD7	90167	broad.mit.edu	37	X	131212241	131212241	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:131212241G>A	uc004ewn.2	-	12	1982	c.1804C>T	c.(1804-1806)CCT>TCT	p.P602S	FRMD7_uc011muy.1_Missense_Mutation_p.P587S	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	602					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GACCCAAAAGGAAAACGAATA	0.433		NA											56	170					0	0	0	0
ATP11C	286410	broad.mit.edu	37	X	138840005	138840005	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:138840005G>A	uc004faz.2	-	23	2770	c.2671C>T	c.(2671-2673)CAG>TAG	p.Q891*	ATP11C_uc004fax.2_Nonsense_Mutation_p.Q99*|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Nonsense_Mutation_p.Q891*	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	891	Helical; (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TACAAAAACTGTGGCAAAATG	0.289		NA											13	33					0	0	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718807	142718807	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:142718807A>G	uc004fbx.2	-	2	494	c.118T>C	c.(118-120)TAT>CAT	p.Y40H	SLITRK4_uc004fby.2_Missense_Mutation_p.Y40H	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	40	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CAGTTGACATAGAGCACATTC	0.373		NA											5	163					0	0	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904855	144904855	+	Silent	SNP	G	G	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:144904855G>A	uc004fcd.2	+	5	1902	c.912G>A	c.(910-912)CCG>CCA	p.P304P	SLITRK2_uc010nsp.2_Silent_p.P304P|SLITRK2_uc010nso.2_Silent_p.P304P|SLITRK2_uc011mwq.1_Silent_p.P304P|SLITRK2_uc011mwr.1_Silent_p.P304P|SLITRK2_uc011mws.1_Silent_p.P304P|SLITRK2_uc004fcg.2_Silent_p.P304P|SLITRK2_uc011mwt.1_Silent_p.P304P	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	304	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGCCGGCCGCCCAAAATGA	0.557		NA											59	133					0	0	0	0
PRAMEF18	391003	broad.mit.edu	37	1	13474787	13474788	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr1:13474787_13474788insG	uc009vnu.1	-	3	1388_1389	c.1341_1342insC	c.(1339-1344)CCCAACfs	p.P447fs		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	447_448											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAGATCCTGTTGGGCTCCCTTA	0.564		NA											5	9	---	---	---	---	NA	NA	NA	NA
C15orf24	56851	broad.mit.edu	37	15	34376648	34376663	+	Frame_Shift_Del	DEL	CATGGTTGGAATTCAG	CATGGTTGGAATTCAG	-			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr15:34376648_34376663delCATGGTTGGAATTCAG	uc001zhm.2	-	5	614_629	c.601_616delCTGAATTCCAACCATG	c.(601-618)CTGAATTCCAACCATGAGfs	p.L201fs	C15orf24_uc001zhn.2_Frame_Shift_Del_p.L84fs	NM_020154	NP_064539	Q9NPA0	CO024_HUMAN	chromosome 15 open reading frame 24 precursor	201_206	Cytoplasmic (Potential).					cytoplasm|integral to membrane	carbohydrate binding|carboxypeptidase activity|purine nucleotide binding				0		all_lung(180;1.76e-08)		all cancers(64;2.02e-17)|GBM - Glioblastoma multiforme(113;2.15e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)		TCAGGCAACTCATGGTTGGAATTCAGCATATTCATT	0.421		NA											21	105	---	---	---	---	NA	NA	NA	NA
OR5H1	26341	broad.mit.edu	37	3	97851704	97851706	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr3:97851704_97851706delCTT	uc011bgt.1	+	1	163_165	c.163_165delCTT	c.(163-165)CTTdel	p.L55del		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						AGACCCTCACCTTCATATCCCAA	0.424		NA											7	206	---	---	---	---	NA	NA	NA	NA
MICAL1	64780	broad.mit.edu	37	6	109769587	109769587	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr6:109769587delT	uc003ptj.2	-	12	1928	c.1674delA	c.(1672-1674)TCAfs	p.S558fs	MICAL1_uc003ptk.2_Frame_Shift_Del_p.S558fs|MICAL1_uc010kdr.2_Frame_Shift_Del_p.S472fs|MICAL1_uc011eaq.1_Frame_Shift_Del_p.S577fs	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	558	CH.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CCTGCAGCTCTGAGGGTTCCC	0.607		NA											86	191	---	---	---	---	NA	NA	NA	NA
C8orf33	65265	broad.mit.edu	37	8	146278237	146278238	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chr8:146278237_146278238insA	uc003zfc.3	+	2	326_327	c.272_273insA	c.(271-273)TCAfs	p.S91fs	C8orf33_uc003zfd.2_RNA	NM_023080	NP_075568	Q9H7E9	CH033_HUMAN	hypothetical protein LOC65265	91											0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GAGAAGGCCTCAGAGAAACTCG	0.594		NA											18	51	---	---	---	---	NA	NA	NA	NA
CXCR3	2833	broad.mit.edu	37	X	70836869	70836870	+	Frame_Shift_Ins	INS	-	-	AGGT			TCGA-CV-5442-01A-01D-1512-08	TCGA-CV-5442-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4d42594f-c1f4-45ed-8bd2-7701f914d33c	7483ff71-6673-41d5-814c-f4657603964c	g.chrX:70836869_70836870insAGGT	uc004eaf.2	-	2	520_521	c.452_453insACCT	c.(451-453)CTGfs	p.L151fs	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Frame_Shift_Ins_p.L198fs	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	151	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					GAACTATGTTCAGGTAGCGGTC	0.52		NA											10	39	---	---	---	---	NA	NA	NA	NA