Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ATAD3A	55210	broad.mit.edu	37	1	1455561	1455561	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:1455561G>A	uc001afz.1	+	6	793	c.699G>A	c.(697-699)GAG>GAA	p.E233E	ATAD3A_uc001aga.1_Silent_p.E185E|ATAD3A_uc001agb.1_Silent_p.E106E	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	233	Potential.						ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		ACAAGAATGAGATGCTGCGAG	0.687		NA											3	24					0	0	0	0
CAMTA1	23261	broad.mit.edu	37	1	7737774	7737774	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:7737774C>T	uc001aoi.2	+	11	3102	c.2895C>T	c.(2893-2895)CAC>CAT	p.H965H	CAMTA1_uc010nzv.1_Silent_p.H52H|CAMTA1_uc001aok.3_5'Flank	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	965					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCTCCCAGCACGACTGGCTGT	0.557		NA											19	66					0	0	0	0
C1orf151	440574	broad.mit.edu	37	1	19950057	19950057	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:19950057C>G	uc001bci.1	+	3	275	c.202C>G	c.(202-204)CTA>GTA	p.L68V	C1orf151_uc001bch.1_RNA|NBL1_uc009vpl.1_Intron	NM_001032363	NP_001027535	Q5TGZ0	CA151_HUMAN	chromosome 1 open reading frame 151 protein	68						integral to membrane|mitochondrion				central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000323)|Lung NSC(340;0.000401)|Breast(348;0.00043)|Ovarian(437;0.00374)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.58e-05)|Kidney(64;0.000191)|GBM - Glioblastoma multiforme(114;0.000696)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		TCCATATCTTCTACATGGAAA	0.388		NA											16	133					0	0	0	0
HTR6	3362	broad.mit.edu	37	1	19992662	19992662	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:19992662C>T	uc001bcl.2	+	1	883	c.416C>T	c.(415-417)ACG>ATG	p.T139M		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	139	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CTGCGCATGACGCCCCTGCGT	0.687		NA											8	75					0	0	0	0
MED18	54797	broad.mit.edu	37	1	28657231	28657231	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:28657231G>A	uc001bpt.3	+	2	303	c.58G>A	c.(58-60)GAG>AAG	p.E20K	MED18_uc009vtg.2_Missense_Mutation_p.E20K	NM_017638	NP_060108	Q9BUE0	MED18_HUMAN	mediator complex subunit 18	20					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	identical protein binding				0		Colorectal(325;0.000147)|Lung NSC(340;0.000818)|all_lung(284;0.000996)|Renal(390;0.00357)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0557)|Ovarian(437;0.113)		OV - Ovarian serous cystadenocarcinoma(117;2.36e-22)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0141)|READ - Rectum adenocarcinoma(331;0.0649)		TAACATGATGGAGTACCTGTT	0.483		NA											7	34					0	0	0	0
ZMYM6	9204	broad.mit.edu	37	1	35480710	35480710	+	Missense_Mutation	SNP	G	G	A	rs148778794		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:35480710G>A	uc001byh.2	-	5	710	c.482C>T	c.(481-483)CCT>CTT	p.P161L	ZMYM6_uc001byf.1_Missense_Mutation_p.P161L|ZMYM6_uc010oht.1_Missense_Mutation_p.P64L|ZMYM6_uc009vup.2_5'UTR|ZMYM6_uc009vuq.1_Missense_Mutation_p.P161L|ZMYM6_uc009vur.1_5'UTR	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	161					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				ATCTTTGCTAGGATAGGAATT	0.323		NA											12	38					0	0	0	0
INPP5B	3633	broad.mit.edu	37	1	38352663	38352663	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:38352663C>T	uc001ccg.1	-	12	1122	c.1028G>A	c.(1027-1029)CGA>CAA	p.R343Q	INPP5B_uc009vvk.1_Missense_Mutation_p.R284Q|INPP5B_uc001ccf.1_Missense_Mutation_p.R179Q|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	423					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CCCAACCAGTCGGATAAGCTT	0.453		NA											8	77					0	0	0	0
ZNF642	339559	broad.mit.edu	37	1	40961662	40961662	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:40961662C>T	uc001cfo.2	+	6	1806	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F	ZNF642_uc009vwb.2_Silent_p.F504F|ZNF642_uc010ojk.1_Silent_p.F505F	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	504	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			GAAAAGCCTTCAGCTATAACT	0.388		NA											21	54					0	0	0	0
CYP4A22	284541	broad.mit.edu	37	1	47614372	47614372	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:47614372C>G	uc001cqv.1	+	12	1514	c.1463C>G	c.(1462-1464)CCC>CGC	p.P488R		NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	488						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ACCAGGATCCCCATCCCCATG	0.557		NA											23	148					0	0	0	0
PODN	127435	broad.mit.edu	37	1	53537247	53537247	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:53537247G>A	uc001cuv.2	+	3	504	c.497G>A	c.(496-498)CGG>CAG	p.R166Q	PODN_uc001cuw.2_Missense_Mutation_p.R147Q|PODN_uc010onr.1_Missense_Mutation_p.R147Q|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	118	LRR 1.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GAGCTCTCCCGGCTGCACCGG	0.637		NA											4	16					0	0	0	0
LRP8	7804	broad.mit.edu	37	1	53736921	53736921	+	Silent	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:53736921G>C	uc001cvi.1	-	7	1246	c.1104C>G	c.(1102-1104)CTC>CTG	p.L368L	LRP8_uc001cvh.1_5'UTR|LRP8_uc001cvk.1_Silent_p.L198L|LRP8_uc001cvj.1_Silent_p.L368L|LRP8_uc001cvl.1_Silent_p.L239L|LRP8_uc001cvm.1_5'Flank	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	368	EGF-like 1.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						TCTGGTCCAGGAGCTGGAAGC	0.577		NA											7	109					0	0	0	0
DNAJC6	9829	broad.mit.edu	37	1	65845131	65845131	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:65845131A>G	uc001dcd.1	+	5	583	c.419A>G	c.(418-420)AAC>AGC	p.N140S	DNAJC6_uc001dcc.1_Missense_Mutation_p.N171S|DNAJC6_uc010opc.1_Missense_Mutation_p.N127S|DNAJC6_uc001dce.1_Missense_Mutation_p.N197S	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	140	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						AGTCTGCACAACCTTTTTGCT	0.453		NA											8	137					0	0	0	0
LHX8	431707	broad.mit.edu	37	1	75622625	75622625	+	Silent	SNP	T	T	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:75622625T>G	uc001dgo.2	+	9	1522	c.858T>G	c.(856-858)CCT>CCG	p.P286P	LHX8_uc001dgq.2_Silent_p.P225P	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	286						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						ACGTCAGTCCTAATCACTCAT	0.512		NA											22	114					0	0	0	0
CELSR2	1952	broad.mit.edu	37	1	109795151	109795151	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:109795151G>A	uc001dxa.3	+	1	2511	c.2450G>A	c.(2449-2451)CGA>CAA	p.R817Q		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	817	Extracellular (Potential).|Cadherin 7.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CAGTTCCTGCGAGACTCCTAC	0.552		NA											10	79					0	0	0	0
ATP5F1	515	broad.mit.edu	37	1	111996851	111996851	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:111996851G>C	uc001ebc.2	+	3	517	c.96G>C	c.(94-96)AGG>AGC	p.R32S	ATP5F1_uc009wgf.1_Missense_Mutation_p.R179S|ATP5F1_uc001ebd.3_Intron	NM_001688	NP_001679	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	32					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding				0		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGGCAACAAGGACCTTTCATA	0.418		NA											9	71					0	0	0	0
ITGA10	8515	broad.mit.edu	37	1	145538042	145538042	+	Silent	SNP	C	C	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:145538042C>A	uc001eoa.2	+	22	2797	c.2721C>A	c.(2719-2721)GTC>GTA	p.V907V	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.V776V|ITGA10_uc009wiw.2_Silent_p.V764V|ITGA10_uc010oyw.1_Silent_p.V852V	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	907	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGAGCCAGGTCTTCGTGAAGC	0.527		NA											54	174					1.39e-30	1.55e-30	1	0
TCHH	7062	broad.mit.edu	37	1	152080820	152080820	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:152080820C>T	uc001ezp.2	-	2	4873	c.4873G>A	c.(4873-4875)GAA>AAA	p.E1625K	TCHH_uc009wne.1_Missense_Mutation_p.E1625K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1625	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCAGCTGTTCGTCTTCGCGG	0.597		NA											14	99					0	0	0	0
TCHH	7062	broad.mit.edu	37	1	152085245	152085245	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:152085245C>T	uc001ezp.2	-	2	448	c.448G>A	c.(448-450)GAG>AAG	p.E150K	TCHH_uc009wne.1_Missense_Mutation_p.E150K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	150					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCTCCCTCAGCTAGCTCC	0.582		NA											41	184					0	0	0	0
SYT2	127833	broad.mit.edu	37	1	202569513	202569513	+	Silent	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:202569513G>C	uc001gye.2	-	7	1084	c.891C>G	c.(889-891)CTC>CTG	p.L297L	SYT2_uc010pqb.1_Silent_p.L297L|SYT2_uc009xaf.2_Silent_p.L127L	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	297	Phospholipid binding (By similarity).|C2 2.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	CCATCTTCTTGAGGTTCTTAG	0.617		NA									OREG0014101	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	121					0	0	0	0
FMOD	2331	broad.mit.edu	37	1	203316668	203316668	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:203316668G>A	uc001gzr.2	-	2	867	c.731C>T	c.(730-732)TCA>TTA	p.S244L	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	244	LRR 6.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			CTCAAGAGCTGAGGGCAGCCC	0.587		NA											18	162					0	0	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227216783	227216783	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:227216783C>T	uc001hqr.2	-	29	4845	c.3902G>A	c.(3901-3903)TGT>TAT	p.C1301Y	CDC42BPA_uc001hqq.2_Missense_Mutation_p.C600Y|CDC42BPA_uc001hqs.2_Missense_Mutation_p.C1220Y|CDC42BPA_uc009xes.2_Missense_Mutation_p.C1273Y|CDC42BPA_uc010pvs.1_Missense_Mutation_p.C1281Y|CDC42BPA_uc001hqp.2_Missense_Mutation_p.C457Y|CDC42BPA_uc001hqt.2_Missense_Mutation_p.C179Y|CDC42BPA_uc001hqu.1_Missense_Mutation_p.C508Y	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1314	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TACGGTTTGACACCCTTTAGT	0.468		NA											5	51					0	0	0	0
SMYD3	64754	broad.mit.edu	37	1	246498710	246498710	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:246498710G>A	uc001ibl.2	-	3	390	c.295C>T	c.(295-297)CCA>TCA	p.P99S	SMYD3_uc001ibk.2_Missense_Mutation_p.P40S	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	99						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		ACGGAGTCTGGAGGATATCTG	0.408		NA											28	105					0	0	0	0
SEC61A2	55176	broad.mit.edu	37	10	12197928	12197928	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr10:12197928G>C	uc001ile.2	+	7	761	c.614G>C	c.(613-615)AGA>ACA	p.R205T	SEC61A2_uc010qbq.1_Missense_Mutation_p.R183T|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Missense_Mutation_p.R205T	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	205	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				AACACTGGCAGAGGTACATCG	0.522		NA											15	83					0	0	0	0
TYSND1	219743	broad.mit.edu	37	10	71902546	71902546	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr10:71902546G>C	uc001jqr.2	-	3	1515	c.1361C>G	c.(1360-1362)TCA>TGA	p.S454*	TYSND1_uc001jqq.2_RNA|TYSND1_uc001jqs.2_Intron|TYSND1_uc001jqt.2_Intron	NM_173555	NP_775826	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1 isoform a	454	Serine protease.				proteolysis	peroxisome	serine-type endopeptidase activity			large_intestine(1)	1						AAGGATGCCTGAGGTCACCGA	0.642		NA											5	32					0	0	0	0
ZNF518A	9849	broad.mit.edu	37	10	97920007	97920007	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr10:97920007G>A	uc001klp.2	+	6	4785	c.3928G>A	c.(3928-3930)GAA>AAA	p.E1310K	ZNF518A_uc001klo.1_Missense_Mutation_p.E780K|ZNF518A_uc001klq.2_Missense_Mutation_p.E1310K|ZNF518A_uc001klr.2_Missense_Mutation_p.E1310K	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AGATGTCCGTGAAACATTTGG	0.388		NA											5	48					0	0	0	0
ZNF214	7761	broad.mit.edu	37	11	7022446	7022446	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:7022446C>G	uc001mfa.2	-	3	771	c.468G>C	c.(466-468)ATG>ATC	p.M156I	ZNF214_uc010ray.1_Missense_Mutation_p.M156I|ZNF214_uc009yfh.1_Missense_Mutation_p.M156I	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		GTGAACCACTCATGTAGATTT	0.383		NA											35	124					0	0	0	0
TUB	7275	broad.mit.edu	37	11	8118955	8118955	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:8118955C>T	uc001mga.2	+	7	1017	c.868C>T	c.(868-870)CGT>TGT	p.R290C	TUB_uc010rbk.1_Missense_Mutation_p.R296C|TUB_uc001mfy.2_Missense_Mutation_p.R345C	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	290					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		GCACCTGGACCGTGAGGATGG	0.542		NA											11	92					0	0	0	0
LDHA	3939	broad.mit.edu	37	11	18422455	18422455	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:18422455C>T	uc001mok.3	+	4	588	c.316C>T	c.(316-318)CGT>TGT	p.R106C	LDHA_uc010rdc.1_Intron|LDHA_uc009yhn.2_Missense_Mutation_p.R106C|LDHA_uc009yho.2_5'UTR|LDHA_uc001mol.3_Missense_Mutation_p.R106C|LDHA_uc010rdd.1_Missense_Mutation_p.R135C	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	106		Substrate.			glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	GGGAGAAAGCCGTCTTAATTT	0.413		NA											4	52					0	0	0	0
DGKZ	8525	broad.mit.edu	37	11	46389294	46389294	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:46389294G>A	uc001ncn.1	+	4	1055	c.930G>A	c.(928-930)ATG>ATA	p.M310I	DGKZ_uc001nch.1_Missense_Mutation_p.M138I|DGKZ_uc010rgq.1_Missense_Mutation_p.M87I|DGKZ_uc001ncj.1_Missense_Mutation_p.M87I|DGKZ_uc010rgr.1_Missense_Mutation_p.M86I|DGKZ_uc001nck.1_5'UTR|DGKZ_uc001ncl.2_Missense_Mutation_p.M121I|DGKZ_uc001ncm.2_Missense_Mutation_p.M121I|DGKZ_uc009yky.1_Missense_Mutation_p.M121I|DGKZ_uc010rgs.1_Missense_Mutation_p.M121I|DGKZ_uc001nci.1_Missense_Mutation_p.M87I	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	310	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TAGCCAGGATGCTGGTGAGTG	0.642		NA									OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	18					0	0	0	0
DGKZ	8525	broad.mit.edu	37	11	46400012	46400012	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:46400012G>T	uc001ncn.1	+	28	3069	c.2944G>T	c.(2944-2946)GAG>TAG	p.E982*	DGKZ_uc001nch.1_Nonsense_Mutation_p.E810*|DGKZ_uc010rgq.1_Nonsense_Mutation_p.E737*|DGKZ_uc001ncj.1_Nonsense_Mutation_p.E760*|DGKZ_uc010rgr.1_Nonsense_Mutation_p.E759*|DGKZ_uc001nck.1_Nonsense_Mutation_p.E572*|DGKZ_uc001ncl.2_Nonsense_Mutation_p.E794*|DGKZ_uc001ncm.2_Nonsense_Mutation_p.E793*|DGKZ_uc009yky.1_Nonsense_Mutation_p.E794*|DGKZ_uc010rgs.1_Nonsense_Mutation_p.E771*|MDK_uc009ykz.1_5'Flank|MDK_uc001nco.2_5'Flank	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	982					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TGCAGGTGAAGAGCTGATTGA	0.622		NA											9	59					3.07e-06	3.32e-06	1	0
DDB2	1643	broad.mit.edu	37	11	47256845	47256845	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:47256845G>A	uc001neb.2	+	7	1100	c.905G>A	c.(904-906)CGG>CAG	p.R302Q	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.R238Q|DDB2_uc001ned.2_RNA|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Missense_Mutation_p.R161Q|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	302	WD 4.				nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						GATGGAGCCCGGCTCCTGACC	0.612		NA	Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				10	131					0	0	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64698016	64698016	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:64698016G>A	uc001oby.2	+	8	1431	c.846G>A	c.(844-846)CTG>CTA	p.L282L	PPP2R5B_uc001obz.2_Silent_p.L282L	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	282					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						TTCGCGTCCTGATCCCCCTGC	0.612		NA											7	77					0	0	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73067756	73067756	+	Silent	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:73067756C>G	uc001otu.2	+	7	3864	c.3843C>G	c.(3841-3843)CTC>CTG	p.L1281L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1281					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						TCCCACAGCTCCAGGCCCCTC	0.572		NA											4	60					0	0	0	0
OR8B4	283162	broad.mit.edu	37	11	124294096	124294096	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:124294096G>C	uc010sak.1	-	1	672	c.672C>G	c.(670-672)ATC>ATG	p.I224M		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GAATACAGAGGATGTTGGAGA	0.458		NA											4	38					0	0	0	0
IGSF9B	22997	broad.mit.edu	37	11	133789939	133789939	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:133789939G>A	uc001qgx.3	-	18	3912	c.3681C>T	c.(3679-3681)GGC>GGT	p.G1227G		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1227	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCTGCAGGAGGCCCGGGCGAG	0.687		NA											10	36					0	0	0	0
NINJ2	4815	broad.mit.edu	37	12	675230	675230	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:675230G>A	uc001qil.2	-	2	377	c.286C>T	c.(286-288)CTG>TTG	p.L96L	NINJ2_uc010sdr.1_Silent_p.L14L|NINJ2_uc010sds.1_Silent_p.L96L	NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	50	Extracellular (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			ACCGCCTTCAGCCGCATGGCG	0.612		NA											12	43					0	0	0	0
CASC1	55259	broad.mit.edu	37	12	25272139	25272139	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:25272139C>G	uc001rgl.2	-	11	1400	c.1318G>C	c.(1318-1320)GAG>CAG	p.E440Q	CASC1_uc001rgk.2_Missense_Mutation_p.E446Q|CASC1_uc001rgm.3_Missense_Mutation_p.E504Q|CASC1_uc001rgj.2_Missense_Mutation_p.E400Q|CASC1_uc010sje.1_Missense_Mutation_p.E381Q|CASC1_uc010sjf.1_Missense_Mutation_p.E328Q|CASC1_uc010sjg.1_Missense_Mutation_p.E440Q	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	440										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TCATGAACCTCAAGTGTGACC	0.373		NA											5	68					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40745387	40745387	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:40745387G>A	uc001rmg.3	+	44	6549	c.6428G>A	c.(6427-6429)CGC>CAC	p.R2143H	LRRK2_uc009zjw.2_Missense_Mutation_p.R981H|LRRK2_uc001rmi.2_Missense_Mutation_p.R976H	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2143			R -> H (in PARK8).		activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTGACGAGACGCATTTTATTA	0.398		NA											13	53					0	0	0	0
KRT4	3851	broad.mit.edu	37	12	53207700	53207700	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:53207700C>T	uc001saz.2	-	1	636	c.365G>A	c.(364-366)GGC>GAC	p.G122D		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	48						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						GCTTCTGCTGCCAAATCCCCC	0.587		NA											35	103					0	0	0	0
USP15	9958	broad.mit.edu	37	12	62715321	62715321	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:62715321G>C	uc001src.1	+	5	561	c.552G>C	c.(550-552)ATG>ATC	p.M184I	USP15_uc001srb.1_Missense_Mutation_p.M184I|USP15_uc001sra.2_Missense_Mutation_p.M184I	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	184					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		ACAAATACATGAGTAACACAT	0.328		NA											6	42					0	0	0	0
MLXIP	22877	broad.mit.edu	37	12	122622100	122622100	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:122622100C>G	uc001ubq.2	+	12	2117	c.2117C>G	c.(2116-2118)TCA>TGA	p.S706*	MLXIP_uc001ubt.2_Nonsense_Mutation_p.S313*	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	706					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		AACAACTGCTCAGGGAAATCC	0.567		NA											13	136					0	0	0	0
GPR109B	8843	broad.mit.edu	37	12	123200775	123200775	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr12:123200775C>G	uc001ucy.3	-	1	665	c.510G>C	c.(508-510)CAG>CAC	p.Q170H	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	170	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	CAGTGCCATTCTGGATCAGCA	0.522		NA											12	70					0	0	0	0
RNF17	56163	broad.mit.edu	37	13	25376549	25376549	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:25376549G>C	uc001upr.2	+	14	1830	c.1789G>C	c.(1789-1791)GAA>CAA	p.E597Q	RNF17_uc010tdd.1_Missense_Mutation_p.E456Q|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.E597Q|RNF17_uc001ups.2_Missense_Mutation_p.E536Q	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	597					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AGCTAAAGTGGAATTTTTGAA	0.333		NA											6	65					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39266631	39266631	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:39266631A>T	uc001uwv.2	+	1	5459	c.5150A>T	c.(5149-5151)CAC>CTC	p.H1717L		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1717	Extracellular (Potential).|CSPG 12.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAAGGCAACCACAGCATCACT	0.428		NA											8	91					0	0	0	0
FREM2	341640	broad.mit.edu	37	13	39430346	39430346	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:39430346T>A	uc001uwv.2	+	12	7318	c.7009T>A	c.(7009-7011)TTC>ATC	p.F2337I	FREM2_uc001uww.2_Missense_Mutation_p.F423I	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2337	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GAGAGAGGCCTTCACTGTTCA	0.403		NA											7	66					0	0	0	0
FOXO1	2308	broad.mit.edu	37	13	41134162	41134162	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:41134162C>T	uc001uxl.3	-	2	1851	c.1466G>A	c.(1465-1467)AGC>AAC	p.S489N	FOXO1_uc010acc.1_Missense_Mutation_p.S304N	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	489					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		CAGAACCCGGCTGTTGGGCTG	0.522		NA											12	79					0	0	0	0
ANKRD10	55608	broad.mit.edu	37	13	111558412	111558412	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr13:111558412G>A	uc001vrn.2	-	3	558	c.423C>T	c.(421-423)ATC>ATT	p.I141I	ANKRD10_uc001vro.1_Silent_p.I141I|ANKRD10_uc001vrp.1_Silent_p.I141I	NM_017664	NP_060134	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	141	ANK 4.									central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			CAAGGGCACTGATGCATTCTA	0.433		NA											3	14					0	0	0	0
TINF2	26277	broad.mit.edu	37	14	24711353	24711353	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:24711353C>T	uc001woa.3	-	1	528	c.186G>A	c.(184-186)AAG>AAA	p.K62K	TINF2_uc010alm.2_5'Flank|TINF2_uc001wob.3_Silent_p.K62K|TINF2_uc010tof.1_Silent_p.K62K|TINF2_uc001woc.3_Silent_p.K62K	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	62					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		ATACCTTGGCCTTTAGGCCCA	0.562		NA							Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis		OREG0022621	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	88					0	0	0	0
FOXG1	2290	broad.mit.edu	37	14	29237058	29237058	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:29237058G>C	uc001wqe.2	+	1	772	c.573G>C	c.(571-573)ATG>ATC	p.M191I		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	191	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CGCTCATCATGATGGCCATCC	0.418		NA											4	40					0	0	0	0
SMOC1	64093	broad.mit.edu	37	14	70418890	70418890	+	Silent	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:70418890C>G	uc001xls.1	+	2	388	c.135C>G	c.(133-135)CTC>CTG	p.L45L	SMOC1_uc001xlt.1_Silent_p.L45L	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	45	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		AGTGCAACCTCCACTGCTCCA	0.522		NA											26	94					0	0	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73448574	73448574	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:73448574G>A	uc001xnm.2	-	5	1873	c.1233C>T	c.(1231-1233)ATC>ATT	p.I411I	ZFYVE1_uc001xnl.2_5'UTR|ZFYVE1_uc010arj.2_Silent_p.I411I	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	411						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		GGTCATCGGGGATCTCACCGC	0.577		NA											5	79					0	0	0	0
C14orf45	80127	broad.mit.edu	37	14	74523883	74523883	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:74523883C>T	uc010tup.1	+	11	1623	c.1500C>T	c.(1498-1500)ACC>ACT	p.T500T	C14orf45_uc001xpm.1_RNA	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	500											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)		TCTTCATCACCCAGCAAATTG	0.393		NA											15	81					0	0	0	0
TRIP11	9321	broad.mit.edu	37	14	92471271	92471271	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:92471271C>T	uc001xzy.2	-	11	3837	c.3049G>A	c.(3049-3051)GAA>AAA	p.E1017K	TRIP11_uc010auf.1_Missense_Mutation_p.E753K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1017	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CTTTCCGTTTCAGCTTTAGAT	0.303		NA	T	PDGFRB	AML								6	63					0	0	0	0
DICER1	23405	broad.mit.edu	37	14	95562276	95562276	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:95562276G>A	uc001ydw.2	-	24	5163	c.4981C>T	c.(4981-4983)CAC>TAC	p.H1661Y	DICER1_uc010avh.1_Missense_Mutation_p.H559Y|DICER1_uc001ydv.2_Missense_Mutation_p.H1651Y|DICER1_uc001ydx.2_Missense_Mutation_p.H1661Y|DICER1_uc001ydy.1_Missense_Mutation_p.H513Y	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1661					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GATATAAGGTGATTCAGTGTT	0.378		NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				20	126					0	0	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102508999	102508999	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:102508999C>T	uc001yks.2	+	69	12591	c.12427C>T	c.(12427-12429)CGC>TGC	p.R4143C		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4143	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCGTGCGGGCCGCATCTTTGT	0.582		NA											7	63					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412495	105412495	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr14:105412495G>A	uc010axc.1	-	7	9413	c.9293C>T	c.(9292-9294)ACG>ATG	p.T3098M	AHNAK2_uc001ypx.2_Missense_Mutation_p.T2998M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3098						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCGGGGGCCGTCACGTCCGT	0.627		NA											39	236					0	0	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42442333	42442333	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:42442333C>G	uc001zoz.2	-	10	955	c.892G>C	c.(892-894)GAG>CAG	p.E298Q	PLA2G4F_uc001zoy.2_5'Flank|PLA2G4F_uc010bcr.2_Missense_Mutation_p.E49Q|PLA2G4F_uc001zpa.2_Missense_Mutation_p.E49Q|PLA2G4F_uc010bcs.2_Missense_Mutation_p.E85Q	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	298					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		AGAGCCACCTCCTGGCCCTGA	0.617		NA											3	37					0	0	0	0
TP53BP1	7158	broad.mit.edu	37	15	43730581	43730581	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:43730581G>C	uc001zrs.2	-	16	3265	c.3117C>G	c.(3115-3117)ATC>ATG	p.I1039M	TP53BP1_uc010udp.1_Missense_Mutation_p.I1039M|TP53BP1_uc001zrq.3_Missense_Mutation_p.I1044M|TP53BP1_uc001zrr.3_Missense_Mutation_p.I1044M|TP53BP1_uc010udq.1_Missense_Mutation_p.I1044M	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1039					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TGGCTTCACAGATACAGCTCA	0.398		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					15	71					0	0	0	0
NEO1	4756	broad.mit.edu	37	15	73581580	73581580	+	Splice_Site	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:73581580G>A	uc002avm.3	+	25	3884	c.3742_splice	c.e25+1	p.P1248_splice	NEO1_uc010ukx.1_Splice_Site_p.P1237_splice|NEO1_uc010uky.1_Splice_Site_p.Q1248_splice|NEO1_uc010ukz.1_Splice_Site_p.P661_splice|NEO1_uc002avn.3_Splice_Site_p.P886_splice	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor						axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						CCACCCCAGCGTAAGTAGAAG	0.458		NA											4	27					0	0	0	0
SYNM	23336	broad.mit.edu	37	15	99672808	99672808	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr15:99672808G>A	uc002bup.2	+	6	4363	c.4243G>A	c.(4243-4245)GAA>AAA	p.E1415K	SYNM_uc002buo.2_Intron|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1415	Tail.|Interaction with DMD and UTRN.|Interaction with TLN1 and VCL.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						GGAAACCTCTGAACACATTGC	0.527		NA											29	249					0	0	0	0
PRSS36	146547	broad.mit.edu	37	16	31151714	31151714	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:31151714G>A	uc002ebd.2	-	14	2249	c.2190C>T	c.(2188-2190)TCC>TCT	p.S730S	PRSS36_uc010vff.1_Silent_p.S505S|PRSS36_uc010vfg.1_Silent_p.S725S|PRSS36_uc010vfh.1_Intron	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	730	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						GTGTCAAGATGGAGACAGCAG	0.592		NA											6	63					0	0	0	0
PYDC1	260434	broad.mit.edu	37	16	31228221	31228221	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:31228221C>T	uc002ebo.2	-	1	178	c.129G>A	c.(127-129)GCG>GCA	p.A43A	TRIM72_uc002ebn.1_Intron	NM_152901	NP_690865	Q8WXC3	PYDC1_HUMAN	pyrin domain containing 1	43	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding				0						GCTGCCCGAGCGCGCCCCGCG	0.647		NA											5	64					0	0	0	0
NKD1	85407	broad.mit.edu	37	16	50667326	50667326	+	Silent	SNP	C	C	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:50667326C>A	uc002egg.1	+	10	1271	c.1047C>A	c.(1045-1047)CCC>CCA	p.P349P		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	349					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		TGAGGTCCCCCAAGGCCCAGG	0.667		NA											6	59					5.18e-06	5.58e-06	1	0
NUTF2	10204	broad.mit.edu	37	16	67899106	67899106	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:67899106G>C	uc002eup.2	+	2	172	c.73G>C	c.(73-75)GAT>CAT	p.D25H	NUTF2_uc010vkf.1_Missense_Mutation_p.D25H	NM_005796	NP_005787	P61970	NTF2_HUMAN	nuclear transport factor 2	25	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		ATTTGATAATGATAGAACCCA	0.483		NA											5	36					0	0	0	0
AP1G1	164	broad.mit.edu	37	16	71768545	71768545	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr16:71768545G>C	uc010cgg.2	-	22	2648	c.2334C>G	c.(2332-2334)ATC>ATG	p.I778M	AP1G1_uc002fba.2_Missense_Mutation_p.I781M|AP1G1_uc002fbb.2_Missense_Mutation_p.I801M|AP1G1_uc002faz.2_Missense_Mutation_p.I195M	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	778	GAE.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				TGACTTGTGTGATGGTCCCCG	0.453		NA											13	193					0	0	0	0
SMG6	23293	broad.mit.edu	37	17	1972199	1972199	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:1972199C>T	uc002fub.1	-	16	3763	c.3708G>A	c.(3706-3708)ATG>ATA	p.M1236I	SMG6_uc010vqv.1_Missense_Mutation_p.M328I	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	1236	Potential.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						CCATCTGCCTCATCTGACTGT	0.592		NA											5	21					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7579912	7579912	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:7579912T>C	uc002gim.2	-	2	195	c.1A>G	c.(1-3)ATG>GTG	p.M1V	TP53_uc002gig.1_Missense_Mutation_p.M1V|TP53_uc002gih.2_Missense_Mutation_p.M1V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.M1V|TP53_uc010cni.1_Missense_Mutation_p.M1V|TP53_uc002gij.2_Missense_Mutation_p.M1V|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Missense_Mutation_p.M1V|TP53_uc002gio.2_Intron|TP53_uc010vug.1_5'UTR|TP53_uc010cnk.1_Missense_Mutation_p.M16V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	1	Transcription activation (acidic).|Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCTCCTCCATGGCAGTGACC	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	18					0	0	0	0
DNAH2	146754	broad.mit.edu	37	17	7734557	7734557	+	Silent	SNP	C	C	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:7734557C>A	uc002giu.1	+	79	12398	c.12384C>A	c.(12382-12384)ACC>ACA	p.T4128T	DNAH2_uc010cnm.1_Silent_p.T1066T	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4128	TPR 5.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGGCACAAACCCTCTTTGATA	0.557		NA											54	118					4.38e-36	4.91e-36	1	0
MYH13	8735	broad.mit.edu	37	17	10248844	10248844	+	Silent	SNP	G	G	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:10248844G>T	uc002gmk.1	-	14	1443	c.1353C>A	c.(1351-1353)ACC>ACA	p.T451T	MYH13_uc010vvf.1_Silent_p.T126T	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	451	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGGCTGCTTGGTGTCCAGCT	0.512		NA											24	88					1.75e-11	1.94e-11	1	0
NCOR1	9611	broad.mit.edu	37	17	15971267	15971267	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:15971267C>T	uc002gpo.2	-	32	4922	c.4682G>A	c.(4681-4683)CGG>CAG	p.R1561Q	NCOR1_uc002gpn.2_Missense_Mutation_p.R1577Q|NCOR1_uc002gpm.2_Missense_Mutation_p.R82Q|NCOR1_uc010vwb.1_Missense_Mutation_p.R145Q|NCOR1_uc010coy.2_Missense_Mutation_p.R469Q|NCOR1_uc010vwc.1_Missense_Mutation_p.R372Q	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1561	Interaction with ETO.|Interaction with C1D (By similarity).			R -> W (in Ref. 1; AAC33550).	cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGTGGCTCCGATAAACCTC	0.512		NA											18	23					0	0	0	0
AOC3	8639	broad.mit.edu	37	17	41003847	41003847	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:41003847C>T	uc002ibv.2	+	1	647	c.487C>T	c.(487-489)CCC>TCC	p.P163S		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	163	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	TCATGGAGGCCCCCTGCCCTA	0.617		NA											11	37					0	0	0	0
HDAC5	10014	broad.mit.edu	37	17	42155928	42155928	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:42155928G>A	uc002ifd.1	-	26	3480	c.3269C>T	c.(3268-3270)GCC>GTC	p.A1090V	HDAC5_uc002ife.1_Missense_Mutation_p.A1090V|HDAC5_uc002iff.1_Missense_Mutation_p.A1091V|HDAC5_uc010czp.1_Missense_Mutation_p.A1005V	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	1090	Nuclear export signal.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		CGACAGCAAGGCCATGGCGCT	0.692		NA											16	143					0	0	0	0
KIF18B	146909	broad.mit.edu	37	17	43009571	43009571	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:43009571C>A	uc010wji.1	-	10	1379	c.1278G>T	c.(1276-1278)CAG>CAT	p.Q426H	KIF18B_uc002iht.2_Missense_Mutation_p.Q426H|KIF18B_uc010wjh.1_Missense_Mutation_p.Q414H	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				GGGTGCAGGGCTGGCTGGGAG	0.657		NA											3	17					0.00024832	0.000261357	1	0
COIL	8161	broad.mit.edu	37	17	55038285	55038285	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:55038285C>G	uc002iuu.2	-	1	127	c.96G>C	c.(94-96)TTG>TTC	p.L32F		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	32						Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					GGCATCTGTTCAAGTCGACCA	0.587		NA									OREG0024594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	33					0	0	0	0
C17orf70	80233	broad.mit.edu	37	17	79517287	79517287	+	Silent	SNP	G	G	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:79517287G>T	uc002kaq.2	-	3	1288	c.1233C>A	c.(1231-1233)CCC>CCA	p.P411P	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Silent_p.P260P	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	411					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CATGCGTCCTGGGAGACGCGG	0.607		NA											27	101					1.74e-05	1.86e-05	1	0
TSPAN10	83882	broad.mit.edu	37	17	79612251	79612251	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:79612251G>A	uc010die.2	+	2	360	c.270G>A	c.(268-270)CTG>CTA	p.L90L	TSPAN10_uc002kaw.1_Silent_p.L90L|TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10	90	Helical; (Potential).					integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TCTCCCTGCTGGGGCTGCTGG	0.662		NA											19	73					0	0	0	0
ZNF750	79755	broad.mit.edu	37	17	80788944	80788944	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:80788944C>G	uc002kga.2	-	2	1698	c.1387G>C	c.(1387-1389)GAA>CAA	p.E463Q	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	463						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGTAGGCATTCTGTGCTTTTC	0.522		NA											29	216					0	0	0	0
KDM4B	23030	broad.mit.edu	37	19	5047507	5047507	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:5047507C>T	uc002mbq.3	+	6	679	c.453C>T	c.(451-453)ATC>ATT	p.I151I	KDM4B_uc010xil.1_Silent_p.I151I|KDM4B_uc010xim.1_Silent_p.I151I	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	151	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						AGTGGAACATCGGGAGCCTCC	0.662		NA											5	59					0	0	0	0
ZNF358	140467	broad.mit.edu	37	19	7584186	7584186	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:7584186G>A	uc002mgn.2	+	2	228	c.58G>A	c.(58-60)GAA>AAA	p.E20K		NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	20					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						ACCCGTTTATGAAGAGCTCGA	0.577		NA											10	109					0	0	0	0
ZNF615	284370	broad.mit.edu	37	19	52506950	52506950	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:52506950C>T	uc002pye.1	-	3	307	c.15G>A	c.(13-15)CAG>CAA	p.Q5Q	ZNF615_uc002pyf.1_Silent_p.Q5Q|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Silent_p.Q5Q|ZNF615_uc010epi.1_Intron|ZNF615_uc010ydg.1_Intron	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CAAAAGTCACCTGGGCCTGCA	0.333		NA											6	49					0	0	0	0
CNOT3	4849	broad.mit.edu	37	19	54656252	54656252	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:54656252G>T	uc002qdj.1	+	15	2104	c.1793G>T	c.(1792-1794)GGT>GTT	p.G598V	CNOT3_uc010yel.1_Missense_Mutation_p.G598V|CNOT3_uc002qdi.2_Missense_Mutation_p.G511V|CNOT3_uc002qdk.1_Missense_Mutation_p.G598V|CNOT3_uc010ere.1_RNA|CNOT3_uc002qdl.2_Missense_Mutation_p.G53V	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	598	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTGTCGCTGGGTGTCTGTCCA	0.632		NA											8	83					3.1e-07	3.39e-07	1	0
ZNF418	147686	broad.mit.edu	37	19	58438294	58438294	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:58438294C>A	uc002qqs.1	-	4	1547	c.1255G>T	c.(1255-1257)GGT>TGT	p.G419C	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.G334C	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	419	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CCAGTGTGACCTCGCTGATGG	0.463		NA											31	151					6.01e-18	6.71e-18	1	0
C19orf18	147685	broad.mit.edu	37	19	58472888	58472888	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr19:58472888G>A	uc002qqv.2	-	5	507	c.403C>T	c.(403-405)CTC>TTC	p.L135F		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	135	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		AGTGACTCGAGCTGTTGTCTT	0.443		NA											14	86					0	0	0	0
ADAM17	6868	broad.mit.edu	37	2	9676833	9676833	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:9676833C>T	uc002qzu.2	-	3	538	c.355G>A	c.(355-357)GTG>ATG	p.V119M	ADAM17_uc010ewy.2_Missense_Mutation_p.V119M|ADAM17_uc010ewz.2_Intron|ADAM17_uc010exb.1_Missense_Mutation_p.V119M|ADAM17_uc002qzv.2_Missense_Mutation_p.V119M	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	119					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TAACCAACCACGTGTCCAGTG	0.428		NA											7	57					0	0	0	0
MRPL35	51318	broad.mit.edu	37	2	86433353	86433353	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:86433353C>T	uc002srg.3	+	2	226	c.168C>T	c.(166-168)TCC>TCT	p.S56S	MRPL35_uc002srf.3_Silent_p.S56S	NM_016622	NP_057706	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35 isoform a	56					translation	mitochondrial ribosome	structural constituent of ribosome				0						TTGTTTCCTCCACTCCCAGAC	0.418		NA											20	127					0	0	0	0
NCK2	8440	broad.mit.edu	37	2	106498121	106498121	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:106498121G>A	uc002tdg.2	+	4	1006	c.564G>A	c.(562-564)CTG>CTA	p.L188L	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Silent_p.L188L	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	188					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCGCCTCGCTGAGCAATGGCC	0.647		NA											12	94					0	0	0	0
YSK4	80122	broad.mit.edu	37	2	135756548	135756548	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:135756548G>C	uc002tue.1	-	5	365	c.334C>G	c.(334-336)CAA>GAA	p.Q112E	YSK4_uc010fne.1_Missense_Mutation_p.Q84E|YSK4_uc002tuf.1_Missense_Mutation_p.Q112E|YSK4_uc010fnc.1_Missense_Mutation_p.Q112E|YSK4_uc010fnd.1_Intron|YSK4_uc010zbg.1_Missense_Mutation_p.Q112E|YSK4_uc002tui.3_Missense_Mutation_p.Q129E	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	112							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCCCATTCTTGAAGCGATGAG	0.443		NA											9	61					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160241870	160241870	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:160241870G>C	uc002uao.2	-	23	3834	c.3482C>G	c.(3481-3483)GCT>GGT	p.A1161G	BAZ2B_uc002uap.2_Missense_Mutation_p.A1125G	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTCTCCAAGAGCTGTTTTAGC	0.323		NA											4	46					0	0	0	0
SCN3A	6328	broad.mit.edu	37	2	165949010	165949010	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:165949010C>G	uc002ucx.2	-	27	5053	c.4561G>C	c.(4561-4563)GAT>CAT	p.D1521H	SCN3A_uc010zcy.1_Missense_Mutation_p.D4H|SCN3A_uc002ucy.2_Missense_Mutation_p.D1472H|SCN3A_uc002ucz.2_Missense_Mutation_p.D1472H	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1521						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GTTACAAAATCAAAGACCATT	0.353		NA											16	56					0	0	0	0
FARP2	9855	broad.mit.edu	37	2	242407683	242407683	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr2:242407683C>T	uc002wbi.1	+	18	2139	c.2022C>T	c.(2020-2022)CTC>CTT	p.L674L		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	674	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		ACTTGCCTCTCAACACGTTCC	0.567		NA											9	53					0	0	0	0
C20orf117	140710	broad.mit.edu	37	20	35443718	35443718	+	Silent	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:35443718G>C	uc002xgd.1	-	5	1740	c.1413C>G	c.(1411-1413)CTC>CTG	p.L471L	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	471											0		Myeloproliferative disorder(115;0.00874)				TGGCATGGATGAGCTTGGTGT	0.637		NA											24	46					0	0	0	0
CSTF1	1477	broad.mit.edu	37	20	54972832	54972832	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:54972832G>A	uc002xxl.1	+	4	780	c.580G>A	c.(580-582)GAT>AAT	p.D194N	CSTF1_uc002xxm.1_Missense_Mutation_p.D194N|CSTF1_uc002xxn.1_Missense_Mutation_p.D194N|CSTF1_uc002xxo.1_Missense_Mutation_p.D137N	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1	194	WD 2.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)			TGGTTCAAGGGATTATACTCT	0.393		NA											7	54					0	0	0	0
LAMA5	3911	broad.mit.edu	37	20	60888187	60888187	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:60888187C>T	uc002ycq.2	-	65	8979	c.8912G>A	c.(8911-8913)CGG>CAG	p.R2971Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2971	Laminin G-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACACGAGCCGCAGCTCCTG	0.652		NA											14	7					0	0	0	0
CABLES2	81928	broad.mit.edu	37	20	60966046	60966046	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr20:60966046C>T	uc002ycv.2	-	10	1425	c.1418G>A	c.(1417-1419)CGC>CAC	p.R473H		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	473					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			CTGGGTGAGGCGCCTGTAATG	0.612		NA											24	71					0	0	0	0
CRKL	1399	broad.mit.edu	37	22	21304053	21304053	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr22:21304053G>A	uc002ztf.2	+	3	1341	c.832G>A	c.(832-834)GAA>AAA	p.E278K	CRKL_uc002ztg.1_RNA	NM_005207	NP_005198	P46109	CRKL_HUMAN	v-crk sarcoma virus CT10 oncogene homolog	278	SH3 2.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity				0	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			GTGGGAAGGCGAAGTGAACGG	0.453		NA											18	218					0	0	0	0
TOP3B	8940	broad.mit.edu	37	22	22313587	22313587	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr22:22313587C>G	uc002zvs.2	-	16	2257	c.1822G>C	c.(1822-1824)GAG>CAG	p.E608Q	TOP3B_uc010gtm.1_Missense_Mutation_p.E153Q|TOP3B_uc002zvr.2_Missense_Mutation_p.E333Q|TOP3B_uc010gtl.2_Missense_Mutation_p.E608Q|TOP3B_uc002zvt.3_Missense_Mutation_p.E608Q	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	608					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		AAAGACACCTCCATCAACTCA	0.602		NA											6	83					0	0	0	0
MYO18B	84700	broad.mit.edu	37	22	26228956	26228956	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr22:26228956C>A	uc003abz.1	+	16	3302	c.3052C>A	c.(3052-3054)CCC>ACC	p.P1018T	MYO18B_uc003aca.1_Missense_Mutation_p.P899T|MYO18B_uc010guy.1_Missense_Mutation_p.P899T|MYO18B_uc010guz.1_Missense_Mutation_p.P899T|MYO18B_uc011aka.1_Missense_Mutation_p.P172T|MYO18B_uc011akb.1_Missense_Mutation_p.P531T	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1018	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGATCAAAATCCCTCTCAGGT	0.488		NA											10	51					1.59e-06	1.73e-06	1	0
CPNE9	151835	broad.mit.edu	37	3	9747714	9747714	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:9747714G>C	uc003bsd.2	+	6	515	c.344G>C	c.(343-345)GGA>GCA	p.G115A		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	115										ovary(2)	2	Medulloblastoma(99;0.227)					GAGGTGATTGGAGGCCAGGGC	0.587		NA											4	44					0	0	0	0
IL17RE	132014	broad.mit.edu	37	3	9945094	9945094	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:9945094C>A	uc003btu.2	+	3	263	c.146C>A	c.(145-147)ACT>AAT	p.T49N	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Missense_Mutation_p.T49N|IL17RE_uc011atn.1_Intron|IL17RE_uc003btw.2_Missense_Mutation_p.T49N|IL17RE_uc003btx.2_Intron|IL17RE_uc010hcq.2_Missense_Mutation_p.T49N|IL17RE_uc003bty.2_Intron	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	49	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GACAGTTTCACTGGTGAGTCG	0.512		NA											10	38					1.62e-10	1.79e-10	1	0
TGFBR2	7048	broad.mit.edu	37	3	30729875	30729875	+	Splice_Site	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:30729875G>A	uc003ceo.2	+	6	1779	c.1397_splice	c.e6-1	p.E466_splice	TGFBR2_uc003cen.2_Splice_Site_p.E491_splice	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II						activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						TTTCTTCACAGAAGTAAAAGA	0.512		NA											15	70					0	0	0	0
TGFBR2	7048	broad.mit.edu	37	3	30729917	30729917	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:30729917G>A	uc003ceo.2	+	6	1820	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	TGFBR2_uc003cen.2_Missense_Mutation_p.E505K	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	480	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CAAGGTGCGGGAGCACCCCTG	0.507		NA											15	68					0	0	0	0
ROBO2	6092	broad.mit.edu	37	3	77666731	77666731	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:77666731G>C	uc003dpy.3	+	22	4004	c.3361G>C	c.(3361-3363)GAA>CAA	p.E1121Q	ROBO2_uc003dpz.2_Missense_Mutation_p.E1125Q|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.E1125Q|ROBO2_uc003dqa.2_Missense_Mutation_p.E248Q	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1121	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCTGGAAGATGAACTGGAAGA	0.458		NA											16	55					0	0	0	0
PVRL3	25945	broad.mit.edu	37	3	110845177	110845177	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:110845177T>C	uc003dxt.1	+	5	1064	c.1064T>C	c.(1063-1065)ATT>ACT	p.I355T	PVRL3_uc003dxu.1_Missense_Mutation_p.I332T	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	355	Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						GTCATCTACATTTCAGGTAAG	0.299		NA											13	42					0	0	0	0
GAP43	2596	broad.mit.edu	37	3	115395104	115395104	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:115395104C>T	uc003ebq.2	+	2	661	c.275C>T	c.(274-276)CCA>CTA	p.P92L	GAP43_uc003ebr.2_Missense_Mutation_p.P128L	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	92					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		GAAGCAGCCCCAGCCACTGGC	0.602		NA											6	47					0	0	0	0
ZNF148	7707	broad.mit.edu	37	3	124998088	124998088	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:124998088G>A	uc003ehx.3	-	6	949	c.463C>T	c.(463-465)CTT>TTT	p.L155F	SLC12A8_uc003ehw.3_5'UTR|ZNF148_uc003ehz.3_Missense_Mutation_p.L155F|ZNF148_uc010hsa.2_Missense_Mutation_p.L155F|ZNF148_uc003eia.3_Missense_Mutation_p.L155F|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	155					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TTTATTGTAAGGATCTAGTTC	0.299		NA											31	48					0	0	0	0
RASA2	5922	broad.mit.edu	37	3	141231006	141231006	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:141231006T>A	uc003etz.1	+	2	135	c.135T>A	c.(133-135)TGT>TGA	p.C45*	RASA2_uc010huq.1_Nonsense_Mutation_p.C45*|RASA2_uc003eua.1_Nonsense_Mutation_p.C45*	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	45	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						TGCCAACAGGTGAAGCAAAAA	0.323		NA											15	45					0	0	0	0
IGSF10	285313	broad.mit.edu	37	3	151166371	151166371	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr3:151166371C>T	uc011bod.1	-	4	1398	c.1398G>A	c.(1396-1398)AGG>AGA	p.R466R		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	466	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTTTCACTGGCCTCATCTCTG	0.453		NA											33	162					0	0	0	0
PRKG2	5593	broad.mit.edu	37	4	82056396	82056396	+	Silent	SNP	T	T	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:82056396T>A	uc003hmh.2	-	13	1703	c.1689A>T	c.(1687-1689)GCA>GCT	p.A563A	PRKG2_uc011ccf.1_Silent_p.A143A|PRKG2_uc011ccg.1_Silent_p.A143A|PRKG2_uc011cch.1_Silent_p.A534A	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	563	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GGTAATCAAATGCTTCTGTCA	0.388		NA											12	61					0	0	0	0
MTTP	4547	broad.mit.edu	37	4	100532392	100532392	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:100532392T>C	uc003hvc.3	+	14	2118	c.1862T>C	c.(1861-1863)ATA>ACA	p.I621T	MTTP_uc011cej.1_Missense_Mutation_p.I648T	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	621	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	ACTGGCTACATAGAACGTATG	0.433		NA											15	89					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126238826	126238826	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:126238826C>G	uc003ifj.3	+	1	1260	c.1260C>G	c.(1258-1260)ATC>ATG	p.I420M		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	420	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGAGCCTAATCAAGGTGGCCA	0.607		NA									OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	30					0	0	0	0
GYPB	2994	broad.mit.edu	37	4	144920591	144920591	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr4:144920591G>C	uc003ijm.1	-	3	204	c.148C>G	c.(148-150)CAA>GAA	p.Q50E	GYPA_uc003ijn.2_Intron|GYPB_uc011chs.1_RNA|GYPB_uc011cht.1_RNA|GYPB_uc011chu.1_RNA|GYPB_uc010ioo.1_RNA|GYPB_uc010iop.2_RNA|GYPB_uc011chv.1_RNA|GYPB_uc011chw.1_RNA|GYPB_uc011chx.1_Intron|GYPB_uc011chy.1_RNA|GYPB_uc011chz.1_RNA	NM_002100	NP_002091	P06028	GLPB_HUMAN	glycophorin B precursor	50	Extracellular (Potential).					integral to plasma membrane					0	all_hematologic(180;0.158)					TGGACAAGTTGTCCCGTTTCT	0.328		NA											5	6					0	0	0	0
CTNND2	1501	broad.mit.edu	37	5	11364901	11364901	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:11364901G>A	uc003jfa.1	-	8	1424	c.1279C>T	c.(1279-1281)CGC>TGC	p.R427C	CTNND2_uc010itt.2_Missense_Mutation_p.R336C|CTNND2_uc011cmy.1_Missense_Mutation_p.R90C|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	427	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGATAGACGCGGTCTTCATAG	0.622		NA											16	49					0	0	0	0
TTC33	23548	broad.mit.edu	37	5	40747015	40747015	+	Missense_Mutation	SNP	C	C	T	rs142188985		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:40747015C>T	uc003jma.2	-	2	254	c.106G>A	c.(106-108)GAT>AAT	p.D36N	TTC33_uc011cpm.1_5'UTR|TTC33_uc010ivg.2_Missense_Mutation_p.D36N	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	36							binding			ovary(1)	1						TTCCCTTCATCGTTGTCAACT	0.443		NA											3	32					0	0	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531980	140531980	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:140531980G>A	uc003lir.2	+	1	2142	c.2142G>A	c.(2140-2142)AGG>AGA	p.R714R	PCDHB6_uc011dah.1_Silent_p.R578R	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	714	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTGCAGGAGGAGCAGGGCGG	0.662		NA											16	155					0	0	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553835	140553835	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:140553835C>T	uc003lit.2	+	1	1593	c.1419C>T	c.(1417-1419)GTC>GTT	p.V473V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	473	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGCAGTGTCAGCGCCACAG	0.637		NA											6	85					0	0	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589072	140589072	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:140589072A>T	uc003liz.2	+	1	782	c.593A>T	c.(592-594)AAG>ATG	p.K198M	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	198	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCTGGACAAGGCGCTGGAT	0.488		NA											14	56					0	0	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148745675	148745675	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:148745675G>T	uc003lqk.2	+	4	703	c.641G>T	c.(640-642)CGG>CTG	p.R214L	PCYOX1L_uc003lql.2_Missense_Mutation_p.R197L|PCYOX1L_uc010jgz.2_Intron|PCYOX1L_uc003lqm.2_Missense_Mutation_p.R96L|PCYOX1L_uc003lqn.2_Missense_Mutation_p.R124L	NM_024028	NP_076933	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like precursor	214					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTCCTGCGGGCCAGCTAT	0.597		NA											10	35					0.000673444	0.000701782	1	0
CNOT8	9337	broad.mit.edu	37	5	154250259	154250259	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:154250259C>T	uc003lvu.2	+	5	829	c.350C>T	c.(349-351)GCT>GTT	p.A117V	CNOT8_uc011ddf.1_Missense_Mutation_p.A11V|CNOT8_uc011ddg.1_Missense_Mutation_p.A11V|CNOT8_uc011ddh.1_Intron|CNOT8_uc003lvv.2_Missense_Mutation_p.A117V|CNOT8_uc010jig.2_Missense_Mutation_p.A11V|CNOT8_uc010jif.2_Missense_Mutation_p.A11V|CNOT8_uc003lvw.2_Missense_Mutation_p.A117V|CNOT8_uc011ddi.1_Missense_Mutation_p.A11V|CNOT8_uc011ddj.1_Intron	NM_004779	NP_004770	Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	117					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GATCTCCTTGCTAACTCAGGA	0.418		NA						Direct_reversal_of_damage					22	75					0	0	0	0
B4GALT7	11285	broad.mit.edu	37	5	177036573	177036573	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:177036573G>A	uc003mhy.2	+	6	901	c.861G>A	c.(859-861)CTG>CTA	p.L287L	B4GALT7_uc003mhz.2_Silent_p.L173L	NM_007255	NP_009186	Q9UBV7	B4GT7_HUMAN	xylosylprotein beta 1,4-galactosyltransferase 7	287	Lumenal (Potential).				fibril organization|glycosaminoglycan biosynthetic process|negative regulation of fibroblast proliferation|protein modification process|proteoglycan metabolic process	Golgi cisterna membrane|integral to membrane	metal ion binding|xylosylprotein 4-beta-galactosyltransferase activity			pancreas(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGGAGGCCTGAACACTGTGA	0.612		NA											23	125					0	0	0	0
TNXB	7148	broad.mit.edu	37	6	32020544	32020544	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:32020544G>A	uc003nzl.2	-	26	9214	c.9012C>T	c.(9010-9012)ACC>ACT	p.T3004T		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3051	Fibronectin type-III 22.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGCCCCCCACGGTGACCTCGC	0.682		NA											10	37					0	0	0	0
PRIM2	5558	broad.mit.edu	37	6	57398239	57398239	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:57398239G>T	uc003pdx.2	+	10	1029	c.942G>T	c.(940-942)AAG>AAT	p.K314N		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	314					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TATTTCTGAAGGGCATTGGTT	0.388		NA											11	104					3.07e-06	3.32e-06	1	0
BAI3	577	broad.mit.edu	37	6	69684692	69684692	+	Silent	SNP	G	G	T	rs139424513		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:69684692G>T	uc003pev.3	+	9	2011	c.1563G>T	c.(1561-1563)TCG>TCT	p.S521S	BAI3_uc010kak.2_Silent_p.S521S	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	521	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATCTGATGTCGATGGTGTGGA	0.413		NA											3	33					0.004672	0.00480908	1	0
MAP3K7	6885	broad.mit.edu	37	6	91226264	91226264	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:91226264C>T	uc003pnz.1	-	17	1939	c.1777G>A	c.(1777-1779)GAG>AAG	p.E593K	MAP3K7_uc003pny.1_Missense_Mutation_p.E130K|MAP3K7_uc003poa.1_3'UTR|MAP3K7_uc003pob.1_Missense_Mutation_p.E566K|MAP3K7_uc003poc.1_3'UTR	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	593					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTGATGACCTCTAGTTGTTTT	0.378		NA											19	95					0	0	0	0
TPD52L1	7164	broad.mit.edu	37	6	125569434	125569434	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr6:125569434G>A	uc003pzu.1	+	4	510	c.291G>A	c.(289-291)AAG>AAA	p.K97K	TPD52L1_uc003pzv.1_Silent_p.K97K|TPD52L1_uc003pzw.1_Silent_p.K97K|TPD52L1_uc003pzx.1_Silent_p.K68K|TPD52L1_uc003pzy.1_Silent_p.K68K|TPD52L1_uc003pzz.1_Silent_p.K68K	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1	97					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		CTAGCTACAAGAAAACACATG	0.413		NA											5	17					0	0	0	0
SCIN	85477	broad.mit.edu	37	7	12691524	12691524	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:12691524C>T	uc003ssn.3	+	15	2228	c.2018C>T	c.(2017-2019)TCT>TTT	p.S673F	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Missense_Mutation_p.S426F	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	673	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TCTCTGAAGTCTGGTAAGCTC	0.338		NA											5	12					0	0	0	0
CPVL	54504	broad.mit.edu	37	7	29111497	29111497	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:29111497G>A	uc003szv.2	-	9	875	c.756C>T	c.(754-756)TTC>TTT	p.F252F	CPVL_uc003szw.2_Silent_p.F252F|CPVL_uc003szx.2_Silent_p.F252F	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	252					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TTTGGTACAGGAATTCTGCAT	0.428		NA											40	63					0	0	0	0
FIGNL1	63979	broad.mit.edu	37	7	50514941	50514941	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:50514941C>G	uc003tpc.2	-	4	422	c.45G>C	c.(43-45)CAG>CAC	p.Q15H	FIGNL1_uc003tpb.2_5'UTR|FIGNL1_uc003tpd.2_Missense_Mutation_p.Q15H|FIGNL1_uc003tpe.2_Missense_Mutation_p.Q15H|FIGNL1_uc010kyy.2_Missense_Mutation_p.Q15H	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	15					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				AGTAATTCTTCTGCCATTCAC	0.413		NA											13	26					0	0	0	0
HIP1	3092	broad.mit.edu	37	7	75192564	75192564	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:75192564C>T	uc003uds.1	-	10	848	c.807G>A	c.(805-807)TTG>TTA	p.L269L	HIP1_uc011kfz.1_Silent_p.L146L	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	269					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						ACAGATCTTTCAACCTAGGGG	0.602		NA	T	PDGFRB	CMML								6	65					0	0	0	0
PDK4	5166	broad.mit.edu	37	7	95224335	95224335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:95224335C>T	uc003uoa.2	-	2	592	c.272G>A	c.(271-273)TGG>TAG	p.W91*	PDK4_uc003unz.2_5'Flank	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	91					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			CACCACTTACCAGCTTTTAAC	0.388		NA											16	125					0	0	0	0
FSCN3	29999	broad.mit.edu	37	7	127235925	127235925	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:127235925C>T	uc003vmd.1	+	2	928	c.709C>T	c.(709-711)CCA>TCA	p.P237S	FSCN3_uc003vmc.1_Missense_Mutation_p.P192S|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_Missense_Mutation_p.P103S|FSCN3_uc010llc.1_Missense_Mutation_p.P237S	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	237						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CATGTTATATCCACAGGGCAC	0.582		NA											28	87					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151859737	151859737	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:151859737G>C	uc003wla.2	-	43	11144	c.10925C>G	c.(10924-10926)TCT>TGT	p.S3642C	MLL3_uc003wkz.2_Missense_Mutation_p.S2703C|MLL3_uc003wky.2_Missense_Mutation_p.S1151C	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3642					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGCAGGAGTAGAGGTAGTTTC	0.507		NA	N		medulloblastoma								22	75					0	0	0	0
MLL3	58508	broad.mit.edu	37	7	151859794	151859794	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr7:151859794G>C	uc003wla.2	-	43	11087	c.10868C>G	c.(10867-10869)TCA>TGA	p.S3623*	MLL3_uc003wkz.2_Nonsense_Mutation_p.S2684*|MLL3_uc003wky.2_Nonsense_Mutation_p.S1132*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3623					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATGGGGAGTTGATGGAGCCTT	0.373		NA	N		medulloblastoma								12	56					0	0	0	0
DLC1	10395	broad.mit.edu	37	8	12957657	12957657	+	Missense_Mutation	SNP	C	C	T	rs140340878	byFrequency	TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:12957657C>T	uc003wwm.2	-	9	2633	c.2189G>A	c.(2188-2190)CGA>CAA	p.R730Q	DLC1_uc003wwk.1_Missense_Mutation_p.R293Q|DLC1_uc003wwl.1_Missense_Mutation_p.R327Q|DLC1_uc011kxx.1_Missense_Mutation_p.R219Q	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	730					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GCTCCTCTTTCGTACCATGGG	0.612		NA											6	71					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	93029589	93029589	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:93029589G>T	uc003yfd.2	-	2	175	c.91C>A	c.(91-93)CGT>AGT	p.R31S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R4S|RUNX1T1_uc003yfe.1_5'UTR|RUNX1T1_uc010mao.2_Missense_Mutation_p.R4S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R42S|RUNX1T1_uc003yfh.1_5'UTR|RUNX1T1_uc003yfb.1_5'UTR|RUNX1T1_uc003yff.1_5'UTR|RUNX1T1_uc003yfg.1_5'UTR	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	31		Breakpoint for translocation to form AML1-MTG8 in AML-M2.			generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCTCAGTACGATCTGGAGGA	0.448		NA											9	66					3.86e-05	4.1e-05	1	0
UBR5	51366	broad.mit.edu	37	8	103291308	103291308	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:103291308G>A	uc003ykr.1	-	43	6163	c.6130C>T	c.(6130-6132)CTG>TTG	p.L2044L	UBR5_uc003yks.1_Silent_p.L2044L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2044	Pro-rich.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GCTTCAGCCAGAGGCACTTCA	0.433		NA											7	106					0	0	0	0
SLC25A32	81034	broad.mit.edu	37	8	104417026	104417026	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:104417026G>A	uc003yll.2	-	3	672	c.369C>T	c.(367-369)TAC>TAT	p.Y123Y	SLC25A32_uc011lhr.1_Intron	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	123	Helical; Name=3; (Potential).|Solcar 2.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	CTGAGACAAGGTATTCTGTTG	0.333		NA											6	52					0	0	0	0
OC90	729330	broad.mit.edu	37	8	133051056	133051056	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:133051056C>G	uc003ytg.2	-	6	561	c.561G>C	c.(559-561)TTG>TTC	p.L187F	OC90_uc011lix.1_Missense_Mutation_p.L203F	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	203					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GAAGTGTTGTCAAGTCTTCCT	0.527		NA											4	36					0	0	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228641	142228641	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:142228641G>A	uc003ywd.1	-	4	1253	c.945C>T	c.(943-945)GCC>GCT	p.A315A	SLC45A4_uc003ywc.1_Silent_p.A315A|SLC45A4_uc010meq.1_Silent_p.A313A	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	366					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCTCCTTGGCGGCTTCCTTGA	0.622		NA											22	83					0	0	0	0
GSDMD	79792	broad.mit.edu	37	8	144644225	144644225	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:144644225A>T	uc010mfe.2	+	11	1623	c.920A>T	c.(919-921)GAG>GTG	p.E307V	GSDMD_uc003yyf.2_Missense_Mutation_p.E355V|GSDMD_uc003yyg.2_Missense_Mutation_p.E307V|GSDMD_uc003yyh.2_Missense_Mutation_p.E238V	NM_024736	NP_079012	P57764	GSDMD_HUMAN	gasdermin D	307											0						TTGGACAGAGAGCTGTGCCAG	0.677		NA											24	50					0	0	0	0
RECQL4	9401	broad.mit.edu	37	8	145737627	145737627	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr8:145737627C>G	uc003zdj.2	-	19	3168	c.3136G>C	c.(3136-3138)GAG>CAG	p.E1046Q		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	1046					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCCTTCTCCTCAGCGGTCAAG	0.637		NA	N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				10	42					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21970900	21970901	+	Splice_Site	DNP	CC	CC	TT	rs45476696		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:21970900_21970901CC>TT	uc003zpk.2	-	2	669	c.457_splice	c.e2+1	p.D153_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(22)|p.D153Y(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCAGTCCTCACCTGAGGGACCT	0.599		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	40					0	0	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325493	79325493	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:79325493T>C	uc010mpk.2	-	8	1821	c.1697A>G	c.(1696-1698)CAT>CGT	p.H566R		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	566					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CTCCTCATCATGTTCCACAAG	0.473		NA											23	35					0	0	0	0
MUSK	4593	broad.mit.edu	37	9	113562840	113562840	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:113562840A>C	uc004bey.2	+	14	2280	c.2182A>C	c.(2182-2184)ACC>CCC	p.T728P	MUSK_uc004bez.1_Missense_Mutation_p.T308P	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	728	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						AGATTTAGCCACCAGGAACTG	0.522		NA											81	323					0	0	0	0
NR6A1	2649	broad.mit.edu	37	9	127289143	127289143	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:127289143G>A	uc004bor.1	-	8	1294	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L	NR6A1_uc004boq.1_Silent_p.L367L|NR6A1_uc010mwq.1_Silent_p.L368L	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	372					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						AGAGGTAGATGAGCCGCTCGA	0.493		NA											11	146					0	0	0	0
ZBTB43	23099	broad.mit.edu	37	9	129595320	129595320	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:129595320G>C	uc004bql.2	+	3	805	c.532G>C	c.(532-534)GAG>CAG	p.E178Q	ZBTB43_uc010mxf.2_Missense_Mutation_p.E178Q	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAAAATGAAGAGGAGAGCAC	0.532		NA											7	64					0	0	0	0
RALGPS1	9649	broad.mit.edu	37	9	129937010	129937010	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:129937010G>A	uc004bqo.1	+	11	1126	c.859G>A	c.(859-861)GAA>AAA	p.E287K	RALGPS1_uc011mab.1_Missense_Mutation_p.E287K|RALGPS1_uc011mac.1_Missense_Mutation_p.E287K|RALGPS1_uc004bqq.3_Missense_Mutation_p.E287K	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	287	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						GCTCAGAATCGAACCAGGAAG	0.463		NA											14	190					0	0	0	0
FAM73B	84895	broad.mit.edu	37	9	131830488	131830488	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:131830488G>A	uc004bxa.2	+	13	1467	c.1281G>A	c.(1279-1281)ATG>ATA	p.M427I	FAM73B_uc004bwy.2_RNA|FAM73B_uc004bwz.2_RNA|FAM73B_uc011mbn.1_Missense_Mutation_p.M427I|FAM73B_uc004bxb.2_5'Flank	NM_032809	NP_116198	Q7L4E1	FA73B_HUMAN	hypothetical protein LOC84895	427						integral to membrane				skin(1)	1						TGGTATGCATGAGCTTCTTCG	0.647		NA											33	151					0	0	0	0
BARHL1	56751	broad.mit.edu	37	9	135462894	135462894	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:135462894C>T	uc004cbp.1	+	2	837	c.645C>T	c.(643-645)CTC>CTT	p.L215L		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	215	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		CCGCCTCGCTCAACCTCACCG	0.647		NA											4	22					0	0	0	0
VAV2	7410	broad.mit.edu	37	9	136671217	136671217	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:136671217G>A	uc004ces.2	-	9	868	c.822C>T	c.(820-822)CTC>CTT	p.L274L	VAV2_uc004cer.2_Silent_p.L269L	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	274	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CCTTGAAATCGAGGAAGACCT	0.587		NA											4	36					0	0	0	0
KIAA1984	84960	broad.mit.edu	37	9	139701235	139701235	+	Silent	SNP	C	C	T			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr9:139701235C>T	uc004cjf.2	+	12	1353	c.1305C>T	c.(1303-1305)CTC>CTT	p.L435L	C9orf86_uc004cjm.2_5'Flank|C9orf86_uc004cjh.2_5'Flank|C9orf86_uc004cjj.1_5'Flank|C9orf86_uc004cjk.1_5'Flank|C9orf86_uc004cji.1_5'Flank|C9orf86_uc010nbr.1_5'Flank|LOC100131193_uc004cjg.1_Intron	NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	435										ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		CCAACACCCTCGATTTGAACA	0.632		NA											4	80					0	0	0	0
PHEX	5251	broad.mit.edu	37	X	22095598	22095598	+	Silent	SNP	G	G	A			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chrX:22095598G>A	uc004dah.2	+	5	644	c.441G>A	c.(439-441)GCG>GCA	p.A147A	PHEX_uc011mjr.1_Silent_p.A147A|PHEX_uc011mjs.1_Silent_p.A50A	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	147	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TTTCAGAAGCGATTGAAAAAG	0.438		NA											25	59					0	0	0	0
FUBP1	8880	broad.mit.edu	37	1	78444669	78444676	+	Frame_Shift_Del	DEL	ACTGTTGA	ACTGTTGA	-	rs139086388	byFrequency	TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr1:78444669_78444676delACTGTTGA	uc001dii.2	-	1	102_109	c.13_20delTCAACAGT	c.(13-21)TCAACAGTGfs	p.S5fs	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Frame_Shift_Del_p.S5fs|DNAJB4_uc010orn.1_5'Flank	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	5_7					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						GGGGGGAGGCACTGTTGAATAGTCTGCC	0.462		NA											15	49	---	---	---	---	NA	NA	NA	NA
OR4S1	256148	broad.mit.edu	37	11	48328525	48328525	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr11:48328525delC	uc010rhu.1	+	1	751	c.751delC	c.(751-753)CCCfs	p.P251fs		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTTCTCATGCCCCCCATGTT	0.483		NA											27	138	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578506	7578514	+	In_Frame_Del	DEL	GGCAGGTCT	GGCAGGTCT	-			TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr17:7578506_7578514delGGCAGGTCT	uc002gim.2	-	5	610_618	c.416_424delAGACCTGCC	c.(415-426)AAGACCTGCCCT>ACT	p.139_142KTCP>T	TP53_uc002gig.1_In_Frame_Del_p.139_142KTCP>T|TP53_uc002gih.2_In_Frame_Del_p.139_142KTCP>T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.7_10KTCP>T|TP53_uc010cng.1_In_Frame_Del_p.7_10KTCP>T|TP53_uc002gii.1_In_Frame_Del_p.7_10KTCP>T|TP53_uc010cnh.1_In_Frame_Del_p.139_142KTCP>T|TP53_uc010cni.1_In_Frame_Del_p.139_142KTCP>T|TP53_uc002gij.2_In_Frame_Del_p.139_142KTCP>T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.46_49KTCP>T|TP53_uc002gio.2_In_Frame_Del_p.7_10KTCP>T|TP53_uc010vug.1_In_Frame_Del_p.100_103KTCP>T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	139_142	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> R (in a sporadic cancer; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C141Y(61)|p.T140I(12)|p.C141*(11)|p.C141R(10)|p.C141W(10)|p.K139N(8)|p.K139K(7)|p.0?(7)|p.T140T(6)|p.K139fs*31(4)|p.C141C(4)|p.C141F(4)|p.K139fs*9(3)|p.C141fs*29(3)|p.K139Q(2)|p.K139R(2)|p.K139E(2)|p.P142F(2)|p.P142A(2)|p.P142T(2)|p.P142S(2)|p.N131fs*27(2)|p.C141S(2)|p.P142fs*28(2)|p.C141fs*8(2)|p.K139*(2)|p.K139T(1)|p.L137_W146del10(1)|p.P142_Q144delPVQ(1)|p.K139fs*4(1)|p.F134_T140>S(1)|p.T140fs*9(1)|p.C141fs*34(1)|p.C141fs*30(1)|p.A138_V143delAKTCPV(1)|p.T140N(1)|p.K139fs*11(1)|p.K139fs*10(1)|p.T140fs*30(1)|p.A138_P142delAKTCP(1)|p.C135_T140delCQLAKT(1)|p.Q136_K139delQLAK(1)|p.C141A(1)|p.C141G(1)|p.C141_P142insXX(1)|p.K139_C141>N(1)|p.K139fs*29(1)|p.C141fs*5(1)|p.P142del(1)|p.P142fs*7(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGCTGCACAGGGCAGGTCTTGGCCAGTTG	0.569		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	44	---	---	---	---	NA	NA	NA	NA
TAF9	6880	broad.mit.edu	37	5	68660786	68660806	+	In_Frame_Del	DEL	TCATCATCATCATCATCGTCA	TCATCATCATCATCATCGTCA	-	rs149295876		TCGA-CV-5444-01A-02D-1512-08	TCGA-CV-5444-11A-01D-1512-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf975479-131b-4b37-927e-cacb1f13e62d	8ad8ae9f-d5e1-4520-bd9a-7f91284489e5	g.chr5:68660786_68660806delTCATCATCATCATCATCGTCA	uc003jwc.1	-	2	1091_1111	c.759_779delTGACGATGATGATGATGATGA	c.(757-780)GATGACGATGATGATGATGATGAC>GAC	p.253_260DDDDDDDD>D	TAF9_uc003jwa.2_Intron|TAF9_uc003jwb.2_Intron|TAF9_uc003jwd.1_In_Frame_Del_p.253_260DDDDDDDD>D|TAF9_uc003jwe.1_In_Frame_Del_p.253_260DDDDDDDD>D|TAF9_uc003jwf.1_In_Frame_Del_p.253_260DDDDDDDD>D	NM_003187	NP_003178	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	253_260	Poly-Asp.				histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		attatcatagtcatcatcatcatcatcgtcatcatcatcat	0.262		NA											7	82	---	---	---	---	NA	NA	NA	NA