Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
SDF4	51150	broad.mit.edu	37	1	1164118	1164118	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:1164118G>A	uc001adh.3	-	2	385	c.56C>T	c.(55-57)GCT>GTT	p.A19V	SDF4_uc001adi.3_Missense_Mutation_p.A19V|SDF4_uc009vjv.2_Intron|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	19					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding	p.A19V(1)		upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		GCAGCACGGAGCCAGGCCAAT	0.692		NA											6	16					0	0	0	0
EPHA8	2046	broad.mit.edu	37	1	22902848	22902848	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:22902848G>A	uc001bfx.1	+	3	423	c.298G>A	c.(298-300)GAG>AAG	p.E100K	EPHA8_uc001bfw.2_Missense_Mutation_p.E100K	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	100	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGTCTATGCTGAGATCAAGTT	0.612		NA											11	54					0	0	0	0
COL16A1	1307	broad.mit.edu	37	1	32118423	32118423	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:32118423C>T	uc001btk.1	-	71	5009	c.4644G>A	c.(4642-4644)ATG>ATA	p.M1548I	COL16A1_uc001bti.1_Missense_Mutation_p.M162I|COL16A1_uc001btj.1_Missense_Mutation_p.M1346I	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1548	Triple-helical region 1 (COL1) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTGTTGCACCCATCTTGCCAT	0.592		NA											9	25					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75072310	75072310	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:75072310G>A	uc001dgg.2	-	10	1683	c.1464C>T	c.(1462-1464)GAC>GAT	p.D488D	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.D282D	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	488	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTTCCTGGTCGTCTTCCAAGA	0.358		NA											70	50					0	0	0	0
LRRC8D	55144	broad.mit.edu	37	1	90398915	90398915	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:90398915C>T	uc001dnm.2	+	3	713	c.288C>T	c.(286-288)AAC>AAT	p.N96N	LRRC8D_uc001dnn.2_Silent_p.N96N	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	96						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GGACAACAAACGACATTTCCT	0.498		NA											31	10					0	0	0	0
ABCD3	5825	broad.mit.edu	37	1	94953518	94953518	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:94953518G>A	uc001dqn.3	+	13	1238	c.1136G>A	c.(1135-1137)CGT>CAT	p.R379H	ABCD3_uc010oto.1_Missense_Mutation_p.R403H|ABCD3_uc010otp.1_Missense_Mutation_p.R306H|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.R67H	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	379					peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTGGCTGGGCGTGAAATGACT	0.323		NA											17	72					0	0	0	0
ZNF687	57592	broad.mit.edu	37	1	151260525	151260525	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:151260525G>A	uc001exq.2	+	2	1856	c.1758G>A	c.(1756-1758)AAG>AAA	p.K586K	ZNF687_uc001exp.1_Silent_p.K595K|ZNF687_uc009wmo.2_Silent_p.K586K|ZNF687_uc009wmp.2_Silent_p.K586K	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	586					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTGAACACAAGGACAAGGGGC	0.607		NA											13	53					0	0	0	0
DARC	2532	broad.mit.edu	37	1	159175312	159175312	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:159175312C>T	uc001fto.2	+	2	323	c.83C>T	c.(82-84)TCT>TTT	p.S28F	DARC_uc001ftp.3_Missense_Mutation_p.S30F	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	28	Extracellular (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					GTATGGAATTCTTCCTATGGT	0.537		NA											11	54					0	0	0	0
NLRP3	114548	broad.mit.edu	37	1	247597516	247597516	+	Silent	SNP	C	C	T	rs143175395		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:247597516C>T	uc001icr.2	+	7	2577	c.2439C>T	c.(2437-2439)TTC>TTT	p.F813F	NLRP3_uc001ics.2_Silent_p.F813F|NLRP3_uc001icu.2_Silent_p.F813F|NLRP3_uc001icw.2_Silent_p.F756F|NLRP3_uc001icv.2_Silent_p.F756F|NLRP3_uc010pyw.1_Silent_p.F791F	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	813	LRR 3.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCGGTGACTTCGGAATCAGAC	0.567		NA											60	32					0	0	0	0
SFMBT2	57713	broad.mit.edu	37	10	7205769	7205769	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:7205769C>G	uc009xio.1	-	21	2739	c.2648G>C	c.(2647-2649)AGA>ACA	p.R883T	SFMBT2_uc001ijn.1_Missense_Mutation_p.R883T|SFMBT2_uc010qay.1_Missense_Mutation_p.R718T	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	883	SAM.				regulation of transcription, DNA-dependent	nucleus		p.R883T(1)		ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CACTTTGACTCTCTCGATCTG	0.567		NA											8	23					0	0	0	0
CELF2	10659	broad.mit.edu	37	10	11308601	11308601	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:11308601G>A	uc001iki.3	+	6	650	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q	CELF2_uc010qbi.1_Intron|CELF2_uc010qbj.1_Silent_p.Q186Q|CELF2_uc001ikk.2_Silent_p.Q193Q|CELF2_uc001ikl.3_Silent_p.Q193Q|CELF2_uc010qbk.1_Intron|CELF2_uc010qbl.1_Silent_p.Q162Q|CELF2_uc010qbm.1_Intron|CELF2_uc001iko.3_Silent_p.Q162Q|CELF2_uc001ikp.3_Silent_p.Q162Q|CELF2_uc010qbn.1_Silent_p.Q170Q|CELF2_uc010qbo.1_Silent_p.Q75Q|CELF2_uc010qbp.1_Intron	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	186	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 2.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						CAATGGCACAGAATGCAATCA	0.448		NA											11	20					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16962010	16962010	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:16962010C>T	uc001ioo.2	-	44	6825	c.6773G>A	c.(6772-6774)CGC>CAC	p.R2258H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2258	CUB 16.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity	p.R2258H(1)		ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGCTGTATGCGTGTTTCCGG	0.438		NA											8	26					0	0	0	0
ZNF488	118738	broad.mit.edu	37	10	48370659	48370659	+	Missense_Mutation	SNP	C	C	T	rs149252316		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:48370659C>T	uc001jex.2	+	2	289	c.127C>T	c.(127-129)CGG>TGG	p.R43W	ZNF488_uc001jey.2_5'UTR	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAGCTGGGCCGGGGCTGCAA	0.677		NA											13	64					0	0	0	0
PCDH15	65217	broad.mit.edu	37	10	55582486	55582486	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:55582486G>T	uc001jju.1	-	33	5395	c.5000C>A	c.(4999-5001)CCT>CAT	p.P1667H	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P1664H|PCDH15_uc010qhw.1_Missense_Mutation_p.P1627H|PCDH15_uc010qhx.1_Missense_Mutation_p.P1598H|PCDH15_uc010qhy.1_Missense_Mutation_p.P1674H|PCDH15_uc010qhz.1_Missense_Mutation_p.P1669H|PCDH15_uc010qia.1_Missense_Mutation_p.P1647H|PCDH15_uc010qib.1_Missense_Mutation_p.P1644H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1667	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.P1674H(1)|p.P1667H(1)		pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGAGAAGTGAGGCCTGGGAAA	0.418		NA								HNSCC(58;0.16)			37	38					7.83e-31	9.33e-31	1	0
RHOBTB1	9886	broad.mit.edu	37	10	62632017	62632017	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:62632017C>T	uc001jli.2	-	11	2285	c.1847G>A	c.(1846-1848)TGT>TAT	p.C616Y	RHOBTB1_uc001jlh.2_Missense_Mutation_p.C616Y|RHOBTB1_uc001jlj.2_Missense_Mutation_p.C616Y|RHOBTB1_uc001jlk.2_Missense_Mutation_p.C616Y|RHOBTB1_uc009xpe.1_Missense_Mutation_p.C554Y|RHOBTB1_uc009xpd.2_Intron|RHOBTB1_uc001jll.2_Missense_Mutation_p.C366Y	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	616					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					GTGGTGCAAACACCAGGCGGC	0.468		NA											11	53					0	0	0	0
CYP2C19	1557	broad.mit.edu	37	10	96580294	96580294	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:96580294G>T	uc010qnz.1	+	6	861	c.861G>T	c.(859-861)TTG>TTT	p.L287F	CYP2C19_uc010qny.1_Missense_Mutation_p.L265F	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	287					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TTGAAAACTTGGTAATCACTG	0.413		NA											12	56					6.4e-05	6.93e-05	1	0
FGFR2	2263	broad.mit.edu	37	10	123274743	123274743	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr10:123274743A>G	uc010qtk.1	-	9	1822	c.1175T>C	c.(1174-1176)GTG>GCG	p.V392A	FGFR2_uc010qtg.1_Missense_Mutation_p.V280A|FGFR2_uc010qth.1_Missense_Mutation_p.V277A|FGFR2_uc010qti.1_Missense_Mutation_p.V303A|FGFR2_uc010qtj.1_Missense_Mutation_p.V393A|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Missense_Mutation_p.V277A|FGFR2_uc001lfl.3_Missense_Mutation_p.V393A|FGFR2_uc001lfm.2_Missense_Mutation_p.V304A|FGFR2_uc001lfn.3_RNA|FGFR2_uc001lfg.3_Missense_Mutation_p.V2A	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	392	Helical; (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.V392A(1)		endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GACTGTTACCACCATACAGGC	0.522		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				29	37					0	0	0	0
DCHS1	8642	broad.mit.edu	37	11	6648366	6648366	+	Silent	SNP	A	A	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr11:6648366A>G	uc001mem.1	-	14	6314	c.5904T>C	c.(5902-5904)CGT>CGC	p.R1968R		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1968	Cadherin 19.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCGGGGCAGACGTAGGCGCA	0.612		NA											23	53					0	0	0	0
CPT1A	1374	broad.mit.edu	37	11	68566776	68566776	+	Silent	SNP	C	C	T	rs143731699		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr11:68566776C>T	uc001oog.3	-	6	773	c.603G>A	c.(601-603)CGG>CGA	p.R201R	CPT1A_uc001oof.3_Silent_p.R201R|CPT1A_uc009ysj.2_Silent_p.R201R	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	201	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GTGCTGTCATCCGTTTGAAGT	0.393		NA											86	137					0	0	0	0
ATN1	1822	broad.mit.edu	37	12	7046142	7046142	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr12:7046142C>A	uc001qrw.1	+	5	1949	c.1712C>A	c.(1711-1713)TCT>TAT	p.S571Y	ATN1_uc001qrx.1_Missense_Mutation_p.S571Y	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	571	Poly-Ser.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GTCTCTTCCTCTTCCAACTCT	0.632		NA											15	80					1.15e-07	1.3e-07	1	0
GYS2	2998	broad.mit.edu	37	12	21692267	21692267	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr12:21692267G>A	uc001rfb.2	-	15	2070	c.1815C>T	c.(1813-1815)TAC>TAT	p.Y605Y		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	605					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						TGGCATGCTGGTAATACTATT	0.328		NA											49	94					0	0	0	0
OSBPL8	114882	broad.mit.edu	37	12	76767187	76767187	+	Silent	SNP	A	A	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr12:76767187A>G	uc001sye.1	-	18	2334	c.1854T>C	c.(1852-1854)GTT>GTC	p.V618V	OSBPL8_uc001syf.1_Silent_p.V576V|OSBPL8_uc001syg.1_Silent_p.V576V|OSBPL8_uc001syh.1_Silent_p.V593V	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	618					lipid transport		lipid binding			ovary(1)	1						ATATTTGATTAACACAGTCAC	0.294		NA											3	65					0	0	0	0
ZC3H13	23091	broad.mit.edu	37	13	46543408	46543408	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr13:46543408C>T	uc010tfw.1	-	13	3277	c.3271G>A	c.(3271-3273)GGT>AGT	p.G1091S	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.G1091S|ZC3H13_uc001vat.1_Missense_Mutation_p.G1091S	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1091							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GGGGTACTACCAGGAGTCGTG	0.378		NA											11	40					0	0	0	0
SUCLA2	8803	broad.mit.edu	37	13	48528631	48528631	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr13:48528631G>C	uc001vbs.2	-	7	921	c.864C>G	c.(862-864)ATC>ATG	p.I288M	SUCLA2_uc010tgb.1_Missense_Mutation_p.I228M|SUCLA2_uc010tgc.1_Missense_Mutation_p.I154M|SUCLA2_uc010tgd.1_Missense_Mutation_p.I228M|SUCLA2_uc001vbt.1_RNA	NM_003850	NP_003841	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	288	ATP-grasp.				succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)	1		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	GTAGATCAAAGATTTTCTTTT	0.393		NA											13	42					0	0	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453707	84453707	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr13:84453707G>A	uc001vlk.2	-	1	2822	c.1936C>T	c.(1936-1938)CGA>TGA	p.R646*		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	646	Cytoplasmic (Potential).					integral to membrane		p.R646*(1)		ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GACCGCTTTCGGTTCCTCAGG	0.562		NA											10	15					0	0	0	0
RNASE12	493901	broad.mit.edu	37	14	21058491	21058491	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr14:21058491A>T	uc001vxt.2	-	1	492	c.392T>A	c.(391-393)CTT>CAT	p.L131H	RNASE11_uc010ahv.2_5'Flank|RNASE11_uc010ahx.2_5'Flank|RNASE11_uc010ahw.2_5'Flank|RNASE11_uc001vxs.2_5'Flank|uc001vxu.1_5'Flank	NM_001024822	NP_001019993	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	131						extracellular region	nucleic acid binding|pancreatic ribonuclease activity	p.L131H(1)		upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		ACAAGTGACAAGAACAAACCC	0.463		NA											41	57					0	0	0	0
ACTC1	70	broad.mit.edu	37	15	35084363	35084363	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr15:35084363C>T	uc001ziu.1	-	5	979	c.736G>A	c.(736-738)GAT>AAT	p.D246N	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	246					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding	p.D246N(1)		upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		ACTTGGCCATCAGGCAGTTCA	0.522		NA											6	34					0	0	0	0
CYP11A1	1583	broad.mit.edu	37	15	74630346	74630346	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr15:74630346G>A	uc002axt.2	-	9	1688	c.1533C>T	c.(1531-1533)TTC>TTT	p.F511F	CYP11A1_uc002axs.2_Silent_p.F353F|CYP11A1_uc010bjm.1_Silent_p.F353F|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Silent_p.F429F	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	511					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TAAAGGGCCAGAAGGTGAAGG	0.552		NA											13	33					0	0	0	0
MPG	4350	broad.mit.edu	37	16	129429	129429	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:129429C>T	uc002cfn.2	+	3	363	c.45C>T	c.(43-45)TGC>TGT	p.C15C	MPG_uc002cfm.2_5'UTR|MPG_uc010bqp.2_5'UTR|MPG_uc002cfo.2_Silent_p.C10C	NM_002434	NP_002425	P29372	3MG_HUMAN	N-methylpurine-DNA glycosylase isoform a	15					depurination|DNA dealkylation involved in DNA repair	nucleoplasm	alkylbase DNA N-glycosylase activity|damaged DNA binding|identical protein binding			ovary(1)|skin(1)	2		all_cancers(16;9.01e-08)|all_epithelial(16;7.64e-07)|Hepatocellular(780;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				TACAGTTTTGCCGACGGATGG	0.547		NA						BER_DNA_glycosylases					3	49					0	0	0	0
HN1L	90861	broad.mit.edu	37	16	1747824	1747824	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:1747824C>G	uc002cmg.2	+	4	384	c.348C>G	c.(346-348)TTC>TTG	p.F116L	HN1L_uc010uvi.1_Missense_Mutation_p.F144L|HN1L_uc010brt.2_RNA|HN1L_uc010bru.2_Missense_Mutation_p.L69V|HN1L_uc010uvj.1_Missense_Mutation_p.L97V|HN1L_uc010uvk.1_Missense_Mutation_p.F103L	NM_144570	NP_653171	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	116						cytoplasm|nucleus		p.F116L(1)		upper_aerodigestive_tract(1)	1						ATCATGTTTTCTTATGTGAAG	0.393		NA											28	80					0	0	0	0
ALG1	56052	broad.mit.edu	37	16	5123195	5123195	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:5123195C>G	uc002cym.2	+	3	369	c.328C>G	c.(328-330)CAG>GAG	p.Q110E	ALG1_uc002cyj.2_5'UTR|ALG1_uc002cyn.2_Missense_Mutation_p.Q110E|ALG1_uc010bue.2_5'UTR|ALG1_uc010uxy.1_5'UTR	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	110	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity	p.Q110E(1)		upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				AGTTGTACTTCAGGCTATGTA	0.517		NA											9	38					0	0	0	0
GRIN2A	2903	broad.mit.edu	37	16	10273897	10273897	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:10273897G>A	uc002czo.3	-	2	920	c.372C>T	c.(370-372)ATC>ATT	p.I124I	GRIN2A_uc010uym.1_Silent_p.I124I|GRIN2A_uc002czr.3_Silent_p.I124I|GRIN2A_uc010buk.2_Silent_p.I124I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	124	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAATGCCCAAGATGGGGACGA	0.612		NA											12	27					0	0	0	0
LOC81691	81691	broad.mit.edu	37	16	20856517	20856517	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:20856517C>T	uc002dhv.2	+	18	2341	c.2078C>T	c.(2077-2079)CCA>CTA	p.P693L	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Missense_Mutation_p.P662L|LOC81691_uc002dhw.2_Missense_Mutation_p.P436L|LOC81691_uc002dhy.3_Missense_Mutation_p.P693L	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	693						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						ACAAGGCTCCCAGGGCTTCGT	0.577		NA											4	13					0	0	0	0
CDH16	1014	broad.mit.edu	37	16	66950205	66950205	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:66950205C>T	uc002eql.2	-	4	330	c.257G>A	c.(256-258)CGA>CAA	p.R86Q	CDH16_uc010cdy.2_Missense_Mutation_p.R86Q|CDH16_uc002eqm.2_Missense_Mutation_p.R86Q	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	86	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R86Q(1)		ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CTGCTCCTCTCGGTCCAGGGC	0.622		NA											18	31					0	0	0	0
CHST6	4166	broad.mit.edu	37	16	75513510	75513510	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr16:75513510C>T	uc002fef.2	-	3	397	c.217G>A	c.(217-219)GCG>ACG	p.A73T	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.A73T	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	73	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						ACGTGCCACGCGGGCTCCATT	0.662		NA											12	19					0	0	0	0
TMEM93	83460	broad.mit.edu	37	17	3572587	3572587	+	Silent	SNP	C	C	G	rs1148572		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:3572587C>G	uc002fwf.1	+	2	300	c.147C>G	c.(145-147)CTC>CTG	p.L49L	TAX1BP3_uc002fwc.2_5'Flank|P2RX5_uc002fwd.2_RNA|TAX1BP3_uc002fwe.1_5'Flank|TMEM93_uc002fwg.1_Silent_p.L49L|P2RX5_uc002fwh.1_3'UTR	NM_031298	NP_112588	Q9BV81	TMM93_HUMAN	transmembrane protein 93	49	Helical; (Potential).					integral to membrane					0						TCACCGGCCTCTACGGCTTCA	0.637		NA											11	30					0	0	0	0
NLGN2	57555	broad.mit.edu	37	17	7319416	7319416	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:7319416G>A	uc002ggt.1	+	6	1697	c.1624G>A	c.(1624-1626)GCC>ACC	p.A542T		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	542	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				GACCAACTTCGCCAAGACTGG	0.517		NA											12	25					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7576853	7576853	+	Silent	SNP	C	C	T	rs11575996		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:7576853C>T	uc002gim.2	-	9	1187	c.993G>A	c.(991-993)CAG>CAA	p.Q331Q	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Silent_p.Q331Q|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Silent_p.Q199Q|TP53_uc010cng.1_Silent_p.Q199Q|TP53_uc002gii.1_Silent_p.Q199Q|TP53_uc010cnh.1_Silent_p.Q331Q|TP53_uc010cni.1_Silent_p.Q331Q|TP53_uc002gij.2_Silent_p.Q331Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.I332fs*49(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTTAGTACCTGAAGGGTGA	0.453		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	41					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577082	7577082	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:7577082C>T	uc002gim.2	-	8	1050	c.856G>A	c.(856-858)GAA>AAA	p.E286K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E286K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E154K|TP53_uc010cng.1_Missense_Mutation_p.E154K|TP53_uc002gii.1_Missense_Mutation_p.E154K|TP53_uc010cnh.1_Missense_Mutation_p.E286K|TP53_uc010cni.1_Missense_Mutation_p.E286K|TP53_uc002gij.2_Missense_Mutation_p.E286K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(52)|p.E286*(14)|p.E286G(14)|p.0?(7)|p.E286V(6)|p.E286Q(5)|p.?(2)|p.E286D(2)|p.E286E(2)|p.R283fs*16(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.E286A(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTCTCTTCCTCTGTGCGC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	20					0	0	0	0
SEZ6	124925	broad.mit.edu	37	17	27287979	27287979	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:27287979C>G	uc002hdp.2	-	6	1447	c.1253G>C	c.(1252-1254)GGA>GCA	p.G418A	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.G418A|SEZ6_uc002hdq.1_Missense_Mutation_p.G293A	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	418	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GCGGATCACTCCGCCGCAAGC	0.607		NA											23	113					0	0	0	0
GAS2L2	246176	broad.mit.edu	37	17	34079822	34079822	+	Silent	SNP	C	C	A	rs147495893	by1000genomes	TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:34079822C>A	uc002hjv.1	-	1	76	c.48G>T	c.(46-48)CCG>CCT	p.P16P		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	16					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCACACAGGCGGCCCTAGGG	0.657		NA											16	51					9.17e-09	1.04e-08	1	0
G6PC3	92579	broad.mit.edu	37	17	42148497	42148497	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:42148497T>C	uc002iex.2	+	1	380	c.164T>C	c.(163-165)ATC>ACC	p.I55T	G6PC3_uc002iey.2_5'UTR|G6PC3_uc010czo.2_5'UTR|G6PC3_uc002iez.2_5'UTR|G6PC3_uc002ifa.1_Missense_Mutation_p.I55T	NM_138387	NP_612396	Q9BUM1	G6PC3_HUMAN	glucose-6-phosphatase catalytic subunit 3	55	Helical; (Potential).				gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			skin(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CGTGTGGGCATCGCGGTGCTC	0.612		NA											10	26					0	0	0	0
SLC25A39	51629	broad.mit.edu	37	17	42397759	42397759	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:42397759G>A	uc002ign.2	-	10	1001	c.847C>T	c.(847-849)CGC>TGC	p.R283C	SLC25A39_uc002igm.2_Missense_Mutation_p.R275C|SLC25A39_uc002igo.2_Missense_Mutation_p.R275C|SLC25A39_uc010wiw.1_Missense_Mutation_p.R260C|SLC25A39_uc010czu.2_Missense_Mutation_p.R151C	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	283	Solcar 3.				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane		p.R275C(1)		upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCGACCTGGCGTTGGGTCTTT	0.652		NA											29	21					0	0	0	0
BAHCC1	57597	broad.mit.edu	37	17	79409052	79409052	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr17:79409052G>A	uc002kaf.2	+	3	677	c.677G>A	c.(676-678)AGA>AAA	p.R226K	BAHCC1_uc002kae.2_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	226							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GAGCTGGGCAGAGAGAAGGCG	0.692		NA											6	22					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	7044739	7044739	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr18:7044739A>G	uc002knm.2	-	7	1052	c.958T>C	c.(958-960)TCC>CCC	p.S320P	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	320	Laminin EGF-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTATTGCCGGAGGACACGGTT	0.468		NA											22	120					0	0	0	0
C19orf21	126353	broad.mit.edu	37	19	758639	758639	+	Missense_Mutation	SNP	C	C	T	rs138693251		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:758639C>T	uc002lpo.2	+	2	1776	c.1693C>T	c.(1693-1695)CGG>TGG	p.R565W		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	565	Potential.							p.R565W(1)		upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCAGAGGAGCGGAGAAATGC	0.607		NA											25	42					0	0	0	0
C19orf29	58509	broad.mit.edu	37	19	3613305	3613305	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:3613305C>T	uc002lyh.2	-	9	1590	c.1537G>A	c.(1537-1539)GCG>ACG	p.A513T	C19orf29_uc010xho.1_5'UTR|C19orf29_uc010dtn.2_Missense_Mutation_p.A361T|C19orf29_uc002lyi.3_Missense_Mutation_p.A513T|C19orf29_uc010dto.2_RNA|C19orf29_uc010xhp.1_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	513						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGCCTCCGCGGGGCCGCCC	0.781		NA											8	9					0	0	0	0
DPP9	91039	broad.mit.edu	37	19	4679886	4679886	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:4679886G>A	uc002mba.2	-	21	2805	c.2547C>T	c.(2545-2547)GTC>GTT	p.V849V		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	820					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		TCAGTTGGGAGACGAGGAAGT	0.602		NA											3	11					0	0	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455843	5455843	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:5455843C>T	uc002mca.3	+	1	418	c.341C>T	c.(340-342)GCG>GTG	p.A114V		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	114	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GTGGACTTTGCGGATCTGCCG	0.667		NA											4	109					0	0	0	0
ACTL9	284382	broad.mit.edu	37	19	8807822	8807822	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:8807822G>A	uc002mkl.2	-	1	1351	c.1230C>T	c.(1228-1230)ATC>ATT	p.I410I		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	410						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						TGCGGTACACGATATAGGGAC	0.632		NA											21	36					0	0	0	0
OR7D2	162998	broad.mit.edu	37	19	9296557	9296557	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:9296557A>G	uc002mkz.1	+	1	288	c.100A>G	c.(100-102)ATG>GTG	p.M34V		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	34	Helical; Name=1; (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M34V(1)		ovary(2)|upper_aerodigestive_tract(1)	3						GTTCCTGTCCATGTACCTGGT	0.512		NA											3	27					0	0	0	0
ZNF653	115950	broad.mit.edu	37	19	11598501	11598501	+	Silent	SNP	G	G	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:11598501G>T	uc002mrz.1	-	4	830	c.777C>A	c.(775-777)ACC>ACA	p.T259T		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGCACAGCGGGGTACCCTGCT	0.682		NA											26	47					8.25e-16	9.59e-16	1	0
ZNF708	7562	broad.mit.edu	37	19	21493405	21493405	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:21493405C>A	uc002npq.1	-	2	226	c.28G>T	c.(28-30)GCC>TCC	p.A10S	ZNF708_uc002npr.1_Intron|ZNF708_uc010ecs.1_Intron	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						AATTCTATGGCCACATCCATA	0.388		NA											28	45					1.51e-07	1.69e-07	1	0
ZNF534	147658	broad.mit.edu	37	19	52941603	52941603	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr19:52941603C>A	uc002pzk.2	+	4	990	c.929C>A	c.(928-930)CCT>CAT	p.P310H	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.P297H	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGAGAAGCCTTACAAATGT	0.393		NA											5	28					0.000602214	0.000640273	1	0
CYP1B1	1545	broad.mit.edu	37	2	38301497	38301497	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:38301497G>A	uc002rqo.2	-	3	1438	c.1035C>T	c.(1033-1035)CTC>CTT	p.L345L		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	345			L -> F (in POAG).		visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	ACCTGGTGAAGAGGAGGAGCA	0.602		NA											6	16					0	0	0	0
SMYD5	10322	broad.mit.edu	37	2	73447180	73447180	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:73447180C>T	uc002siw.2	+	3	236	c.207C>T	c.(205-207)GCC>GCT	p.A69A	SMYD5_uc010yre.1_Intron|SMYD5_uc002six.1_5'Flank	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	69							metal ion binding				0						CACCGTCAGCCTGTGACCACT	0.483		NA											20	27					0	0	0	0
SEMA4F	10505	broad.mit.edu	37	2	74902408	74902408	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:74902408C>T	uc002sna.1	+	10	1380	c.1269C>T	c.(1267-1269)GGC>GGT	p.G423G	SEMA4F_uc010ffq.1_Silent_p.G390G|SEMA4F_uc010ffr.1_Silent_p.G35G|SEMA4F_uc002snb.1_Silent_p.G35G|SEMA4F_uc002snc.1_Silent_p.G268G	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	423	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CAGCTGATGGCCACCCCCTGC	0.587		NA									OREG0014721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	25					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152539188	152539188	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:152539188G>A	uc010fnx.2	-	29	3122	c.2931C>T	c.(2929-2931)GAC>GAT	p.D977D		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	977	Nebulin 23.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATTGAGGATGTCTGAAGCTC	0.468		NA											13	10					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179642181	179642181	+	Silent	SNP	G	G	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:179642181G>T	uc010zfg.1	-	26	4835	c.4611C>A	c.(4609-4611)GGC>GGA	p.G1537G	TTN_uc010zfh.1_Silent_p.G1491G|TTN_uc010zfi.1_Silent_p.G1491G|TTN_uc010zfj.1_Silent_p.G1491G|TTN_uc002unb.2_Silent_p.G1537G|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1537							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGAAGATCTGCCTGCCCTGT	0.363		NA											10	25					6.43e-13	7.35e-13	1	0
TTN	7273	broad.mit.edu	37	2	179647599	179647599	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:179647599G>A	uc010zfg.1	-	18	3258	c.3034C>T	c.(3034-3036)CGA>TGA	p.R1012*	TTN_uc010zfh.1_Nonsense_Mutation_p.R966*|TTN_uc010zfi.1_Nonsense_Mutation_p.R966*|TTN_uc010zfj.1_Nonsense_Mutation_p.R966*|TTN_uc002unb.2_Nonsense_Mutation_p.R1012*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1012							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R1012*(2)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGTAAATCGCCCGCTGTCT	0.502		NA											20	29					0	0	0	0
PER2	8864	broad.mit.edu	37	2	239180022	239180022	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr2:239180022C>T	uc002vyc.2	-	6	940	c.703G>A	c.(703-705)GAT>AAT	p.D235N	PER2_uc010znv.1_Missense_Mutation_p.D235N|PER2_uc010znw.1_Missense_Mutation_p.D235N|PER2_uc010fyx.1_Missense_Mutation_p.D235N	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	235	PAS 1.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		ACGCCCACATCGTGAGGCGCC	0.522		NA											19	64					0	0	0	0
SCRT2	85508	broad.mit.edu	37	20	644433	644433	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr20:644433C>T	uc002wec.2	-	2	1384	c.806G>A	c.(805-807)CGC>CAC	p.R269H	SRXN1_uc002web.2_Intron	NM_033129	NP_149120	Q9NQ03	SCRT2_HUMAN	scratch 2 protein	269	C2H2-type 5; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGGCGGCAGCGGTAGTGCTT	0.701		NA											7	6					0	0	0	0
DSCAM	1826	broad.mit.edu	37	21	41719759	41719759	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr21:41719759T>C	uc002yyq.1	-	6	1500	c.1048A>G	c.(1048-1050)AAT>GAT	p.N350D	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	350	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATTTCACCATTGCGGTACCAG	0.502		NA											5	129					0	0	0	0
EFCAB6	64800	broad.mit.edu	37	22	44004470	44004470	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr22:44004470T>C	uc003bdy.1	-	22	2788	c.2573A>G	c.(2572-2574)GAA>GGA	p.E858G	EFCAB6_uc003bdz.1_Missense_Mutation_p.E706G|EFCAB6_uc010gzi.1_Missense_Mutation_p.E706G|EFCAB6_uc010gzj.1_Intron	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	858	EF-hand 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding	p.E858G(1)		ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				ATTATCGGTTTCTAGAAAATT	0.403		NA											12	34					0	0	0	0
SETD5	55209	broad.mit.edu	37	3	9489625	9489625	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:9489625A>G	uc003brt.2	+	15	2473	c.2038A>G	c.(2038-2040)ACT>GCT	p.T680A	SETD5_uc003brs.1_Missense_Mutation_p.T661A|SETD5_uc003bru.2_Missense_Mutation_p.T582A|SETD5_uc003brv.2_Missense_Mutation_p.T569A|SETD5_uc010hck.2_Missense_Mutation_p.T162A|SETD5_uc003brx.2_Missense_Mutation_p.T349A	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	680										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		GTCTGACCCAACTGTGGTGTC	0.443		NA											2	10					0	0	0	0
ITIH1	3697	broad.mit.edu	37	3	52819104	52819104	+	Silent	SNP	T	T	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:52819104T>C	uc003dfs.2	+	12	1476	c.1452T>C	c.(1450-1452)GAT>GAC	p.D484D	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.D85D|ITIH1_uc010hmo.1_Silent_p.D38D|ITIH1_uc003dfu.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	484	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TGGATGTGGATTTGCAGTACC	0.562		NA											22	44					0	0	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111794206	111794206	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:111794206G>C	uc010hqb.2	+	13	1614	c.1444G>C	c.(1444-1446)GGA>CGA	p.G482R	TMPRSS7_uc011bhr.1_Missense_Mutation_p.G337R	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	608	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						CCGCATCATCGGAGGCACAGA	0.552		NA											7	180					0	0	0	0
CHST2	9435	broad.mit.edu	37	3	142841109	142841109	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:142841109G>A	uc003evm.2	+	2	2340	c.1451G>A	c.(1450-1452)CGG>CAG	p.R484Q		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	484	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						AATGCCTGGCGGACCGCCCTC	0.612		NA											6	67					0	0	0	0
TTC14	151613	broad.mit.edu	37	3	180322057	180322057	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:180322057G>A	uc003fkk.2	+	4	663	c.531G>A	c.(529-531)GGG>GGA	p.G177G	TTC14_uc003fkl.2_Silent_p.G177G|TTC14_uc003fkm.2_Silent_p.G177G	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	177	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GTAACCATGGGGATCCTTTAT	0.323		NA											66	56					0	0	0	0
C3orf21	152002	broad.mit.edu	37	3	194947478	194947478	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:194947478G>A	uc003fum.3	-	2	720	c.612C>T	c.(610-612)ATC>ATT	p.I204I	C3orf21_uc011bsw.1_Silent_p.I58I	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	204						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		AGAGGAAGAAGATGGAGTCAC	0.537		NA											8	67					0	0	0	0
RNF168	165918	broad.mit.edu	37	3	196199094	196199094	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr3:196199094C>G	uc003fwq.2	-	6	1850	c.1312G>C	c.(1312-1314)GAG>CAG	p.E438Q	RNF168_uc010iah.2_Missense_Mutation_p.E271Q|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	438					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTATGTCTCTCAAACAGTAGA	0.413		NA											48	195					0	0	0	0
GUF1	60558	broad.mit.edu	37	4	44688655	44688655	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:44688655C>T	uc003gww.3	+	8	1070	c.863C>T	c.(862-864)TCT>TTT	p.S288F	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	288					translation	mitochondrial inner membrane	GTP binding|GTPase activity	p.S288F(1)		upper_aerodigestive_tract(1)	1						AAAATTGTATCTGCACATACT	0.363		NA											15	90					0	0	0	0
USP53	54532	broad.mit.edu	37	4	120213723	120213723	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:120213723C>T	uc003ics.3	+	18	3645	c.2579C>T	c.(2578-2580)TCT>TTT	p.S860F	USP53_uc003icr.3_Missense_Mutation_p.S860F|USP53_uc003icu.3_Missense_Mutation_p.S483F	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	860					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						AATGAACCATCTTCATTATGG	0.388		NA											18	42					0	0	0	0
FAT4	79633	broad.mit.edu	37	4	126240974	126240974	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:126240974G>C	uc003ifj.3	+	1	3408	c.3408G>C	c.(3406-3408)AGG>AGC	p.R1136S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1136	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GAGAAGTAAGGTATTCTTTTG	0.433		NA											29	131					0	0	0	0
KIAA0922	23240	broad.mit.edu	37	4	154542878	154542878	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr4:154542878G>C	uc003inm.3	+	28	3785	c.3733G>C	c.(3733-3735)GAG>CAG	p.E1245Q	KIAA0922_uc010ipp.2_Missense_Mutation_p.E1246Q|KIAA0922_uc010ipq.2_Missense_Mutation_p.E1014Q	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1245	Cytoplasmic (Potential).					integral to membrane		p.E1098Q(1)		upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAGTGACTTTGAGAGGTCTGA	0.428		NA											7	27					0	0	0	0
ATG10	83734	broad.mit.edu	37	5	81549160	81549160	+	Silent	SNP	G	G	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:81549160G>C	uc003khs.2	+	8	1008	c.579G>C	c.(577-579)CTG>CTC	p.L193L	ATG10_uc003khr.2_Silent_p.L193L|ATG10_uc010jas.2_Silent_p.L157L	NM_001131028	NP_001124500	Q9H0Y0	ATG10_HUMAN	APG10 autophagy 10-like	193					autophagy in response to ER overload|positive regulation of protein modification process|protein lipidation|protein modification by small protein conjugation|protein transport	cytoplasm	Atg12 ligase activity|protein binding				0		Lung NSC(167;0.0258)|all_lung(232;0.0294)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;9.94e-41)|Epithelial(54;6.3e-36)|all cancers(79;2.31e-30)		CATCATGGCTGAGCATTGTAG	0.413		NA											14	57					0	0	0	0
IL3	3562	broad.mit.edu	37	5	131398259	131398259	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:131398259C>T	uc003kwe.1	+	4	388	c.335C>T	c.(334-336)ACG>ATG	p.T112M		NM_000588	NP_000579	P08700	IL3_HUMAN	interleukin 3 precursor	112					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			ovary(2)|central_nervous_system(1)	3		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	GCCGCACCCACggtaagctgt	0.308		NA									OREG0016762	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	137					0	0	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559041	140559041	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:140559041G>A	uc011dai.1	+	1	1612	c.1426G>A	c.(1426-1428)GCC>ACC	p.A476T	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	476	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGCGTCAGCGCCACAGACAG	0.657		NA											18	122					0	0	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755613	140755613	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:140755613T>G	uc003ljy.1	+	1	1963	c.1963T>G	c.(1963-1965)TCC>GCC	p.S655A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.S655A	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	655	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCCCTCTCTCCGCCACTGT	0.706		NA											11	33					0	0	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764535	140764535	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:140764535C>T	uc003lka.1	+	1	2069	c.2069C>T	c.(2068-2070)ACG>ATG	p.T690M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGB4_uc003lkc.1_5'Flank|PCDHGA7_uc003ljz.1_Missense_Mutation_p.T690M|PCDHGB4_uc011dav.1_5'Flank	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	690	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATGACCTCACGTTGTACCTG	0.632		NA											27	27					0	0	0	0
GABRG2	2566	broad.mit.edu	37	5	161569195	161569195	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:161569195C>G	uc003lyz.3	+	7	1153	c.795C>G	c.(793-795)TAC>TAG	p.Y265*	GABRG2_uc010jjc.2_Nonsense_Mutation_p.Y305*|GABRG2_uc003lyy.3_Nonsense_Mutation_p.Y265*|GABRG2_uc011dej.1_Nonsense_Mutation_p.Y170*	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	265	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TGTCTGTCTACTTTGATCTGA	0.403		NA											4	128					0	0	0	0
WWC1	23286	broad.mit.edu	37	5	167896016	167896016	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:167896016C>T	uc003lzu.2	+	23	3429	c.3336C>T	c.(3334-3336)GAC>GAT	p.D1112D	WWC1_uc003lzv.2_Silent_p.D1117D|WWC1_uc011den.1_Silent_p.D1118D|WWC1_uc003lzw.2_Silent_p.D910D	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	1112	ADDV motif.|Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CTGCAGATGACGTCTAATCGC	0.418		NA											8	24					0	0	0	0
GRM6	2916	broad.mit.edu	37	5	178416069	178416069	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr5:178416069C>T	uc003mjr.2	-	6	1400	c.1221G>A	c.(1219-1221)GCG>GCA	p.A407A	GRM6_uc010jla.1_Intron|GRM6_uc003mjs.1_Silent_p.A27A	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	407	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TGGCGTACACCGCATCAATCA	0.647		NA											4	17					0	0	0	0
GRM4	2914	broad.mit.edu	37	6	34101144	34101144	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr6:34101144G>A	uc003oir.3	-	1	300	c.130C>T	c.(130-132)CGC>TGC	p.R44C	GRM4_uc011dsn.1_Missense_Mutation_p.R44C|GRM4_uc010jvh.2_Missense_Mutation_p.R44C|GRM4_uc010jvi.2_5'UTR|GRM4_uc010jvk.1_Intron	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	44	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R44C(2)		lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CCATCTATGCGGATGGAATTC	0.612		NA											9	27					0	0	0	0
GPR116	221395	broad.mit.edu	37	6	46846093	46846093	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr6:46846093C>T	uc003oyo.3	-	10	1375	c.1086G>A	c.(1084-1086)AAG>AAA	p.K362K	GPR116_uc003oyp.3_Intron|GPR116_uc003oyq.3_Silent_p.K362K|GPR116_uc010jzi.1_Silent_p.K34K|GPR116_uc003oyr.2_Silent_p.K362K	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	362	Ig-like 1.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CTATTTTCTTCTTGCACTCAT	0.328		NA											9	35					0	0	0	0
HCRTR2	3062	broad.mit.edu	37	6	55113499	55113499	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr6:55113499C>G	uc003pcl.2	+	2	601	c.286C>G	c.(286-288)CTT>GTT	p.L96V	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.L31V	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	96	Helical; Name=2; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity	p.L96V(2)		ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CATAGTCAATCTTTCTCTGGC	0.458		NA											76	95					0	0	0	0
KIAA0415	9907	broad.mit.edu	37	7	4825265	4825265	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:4825265C>T	uc003sne.2	+	9	1165	c.1082C>T	c.(1081-1083)CCG>CTG	p.P361L	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_5'Flank	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	361					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		CGCGGGGACCCGGCCTCTGTG	0.697		NA											5	2					0	0	0	0
FBXL18	80028	broad.mit.edu	37	7	5540952	5540952	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:5540952C>T	uc003soo.2	-	3	1042	c.948G>A	c.(946-948)CCG>CCA	p.P316P	FBXL18_uc003son.3_Silent_p.P316P	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	316										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		TGAAGTAGAACGGGTTGTTGA	0.597		NA											12	15					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82579315	82579315	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:82579315G>A	uc003uhx.2	-	6	10878	c.10589C>T	c.(10588-10590)CCA>CTA	p.P3530L	PCLO_uc003uhv.2_Missense_Mutation_p.P3530L|PCLO_uc010lec.2_Missense_Mutation_p.P495L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3461					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGTTCCAACTGGTTCAGTTTG	0.463		NA											13	21					0	0	0	0
COL1A2	1278	broad.mit.edu	37	7	94056511	94056511	+	Silent	SNP	T	T	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:94056511T>C	uc003ung.1	+	48	3642	c.3171T>C	c.(3169-3171)GGT>GGC	p.G1057G	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1057					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GCCCTGCTGGTCCTTCTGGCC	0.587		NA								HNSCC(75;0.22)			7	12					0	0	0	0
CYP3A4	1576	broad.mit.edu	37	7	99364768	99364768	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:99364768C>T	uc003urv.1	-	8	888	c.784G>A	c.(784-786)GAA>AAA	p.E262K	CYP3A4_uc003urw.1_Missense_Mutation_p.E261K|CYP3A4_uc011kiz.1_Missense_Mutation_p.E221K|CYP3A4_uc011kja.1_Missense_Mutation_p.E213K|CYP3A4_uc011kjb.1_Missense_Mutation_p.E112K	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	262					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TGTGTATCTTCGAGGCGACTT	0.308		NA											16	33					0	0	0	0
EPHB4	2050	broad.mit.edu	37	7	100403272	100403272	+	Silent	SNP	T	T	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:100403272T>G	uc003uwn.1	-	15	3020	c.2529A>C	c.(2527-2529)CCA>CCC	p.P843P	EPHB4_uc003uwm.1_Silent_p.P750P|EPHB4_uc010lhj.1_Silent_p.P843P	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	843	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGGGACAGTCTGGGGGCGGGG	0.607		NA											7	96					0	0	0	0
PTN	5764	broad.mit.edu	37	7	136938277	136938277	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr7:136938277C>G	uc003vtq.2	-	3	586	c.223G>C	c.(223-225)GAG>CAG	p.E75Q	PTN_uc010lmx.2_Missense_Mutation_p.E75Q|PTN_uc003vtr.1_Missense_Mutation_p.E75Q	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	75				E -> G (in Ref. 9; AAV38498).	nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity	p.E75Q(1)		upper_aerodigestive_tract(1)|pancreas(1)	2						TGCTTGCACTCAGCTCCAGTC	0.537		NA											11	53					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3611465	3611465	+	Silent	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:3611465G>A	uc011kwk.1	-	6	1308	c.918C>T	c.(916-918)AAC>AAT	p.N306N		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	306	Extracellular (Potential).|CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGAACTGAGCGTTAAATCCTT	0.418		NA											19	8					0	0	0	0
MTUS1	57509	broad.mit.edu	37	8	17611496	17611496	+	Silent	SNP	G	G	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:17611496G>T	uc003wxv.2	-	2	2295	c.1821C>A	c.(1819-1821)GCC>GCA	p.A607A	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Silent_p.A607A|MTUS1_uc010lsz.2_Silent_p.A607A	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	607						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TCGATTTCACGGCAGATGTTG	0.433		NA											109	35					4.07e-57	4.87e-57	1	0
ADCY8	114	broad.mit.edu	37	8	131880186	131880186	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:131880186G>C	uc003ytd.3	-	9	2372	c.2116C>G	c.(2116-2118)CAA>GAA	p.Q706E	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	706	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCCCTCATTTGAGAATACTGT	0.358		NA								HNSCC(32;0.087)			19	61					0	0	0	0
TG	7038	broad.mit.edu	37	8	133978854	133978854	+	Silent	SNP	C	C	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr8:133978854C>A	uc003ytw.2	+	30	5639	c.5598C>A	c.(5596-5598)GTC>GTA	p.V1866V	TG_uc010mdw.2_Silent_p.V625V|TG_uc011ljb.1_Silent_p.V235V|TG_uc011ljc.1_Silent_p.V20V|TG_uc010mdx.1_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1866	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGTCATTGTCAATGGAAATC	0.453		NA											47	96					3.22e-24	3.82e-24	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	G	A	rs121913387		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	1					0	0	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608276	84608276	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:84608276G>A	uc004amn.2	+	4	2938	c.2891G>A	c.(2890-2892)CGT>CAT	p.R964H		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	964						integral to membrane					0						TCTAAGTCCCGTAGTCGAAGC	0.517		NA											47	90					0	0	0	0
ZNF883	169834	broad.mit.edu	37	9	115760008	115760008	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:115760008C>T	uc011lwy.1	-	5	1771	c.532G>A	c.(532-534)GAA>AAA	p.E178K		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGGATTTTTCCTCAGAATGA	0.403		NA											21	27					0	0	0	0
RGS3	5998	broad.mit.edu	37	9	116267802	116267802	+	Silent	SNP	C	C	T	rs142637936		TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:116267802C>T	uc004bhq.2	+	12	1187	c.978C>T	c.(976-978)TCC>TCT	p.S326S	RGS3_uc004bhr.2_Silent_p.S214S|RGS3_uc004bhs.2_Silent_p.S216S|RGS3_uc004bht.2_Silent_p.S45S|RGS3_uc010muy.2_Silent_p.S45S|RGS3_uc004bhu.2_5'UTR	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	326	PDZ.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CCGTGGATTCCGGTAAGTTAT	0.572		NA											15	19					0	0	0	0
GSN	2934	broad.mit.edu	37	9	124064328	124064328	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:124064328C>A	uc004blf.1	+	2	293	c.232C>A	c.(232-234)CTG>ATG	p.L78M	GSN_uc004bld.1_Missense_Mutation_p.L27M|GSN_uc010mvq.1_Missense_Mutation_p.L38M|GSN_uc010mvr.1_Missense_Mutation_p.L38M|GSN_uc010mvu.1_Missense_Mutation_p.L27M|GSN_uc010mvt.1_Missense_Mutation_p.L27M|GSN_uc010mvs.1_Missense_Mutation_p.L27M|GSN_uc004ble.1_Missense_Mutation_p.L27M|GSN_uc010mvv.1_Missense_Mutation_p.L27M|GSN_uc011lyh.1_Missense_Mutation_p.L44M|GSN_uc011lyi.1_Missense_Mutation_p.L27M|GSN_uc011lyj.1_Missense_Mutation_p.L51M	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	78	Actin-severing (Potential).|Gelsolin-like 1.				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						GAAGTTCGATCTGGTGCCCGT	0.572		NA											29	112					9.39e-14	1.08e-13	1	0
ADAMTS13	11093	broad.mit.edu	37	9	136307841	136307841	+	Silent	SNP	C	C	T			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:136307841C>T	uc004cdv.3	+	18	2655	c.2211C>T	c.(2209-2211)TGC>TGT	p.C737C	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Silent_p.C737C|ADAMTS13_uc004cdu.1_Silent_p.C706C|ADAMTS13_uc004cdw.3_Silent_p.C737C|ADAMTS13_uc004cdx.3_Silent_p.C706C|ADAMTS13_uc004cdy.1_Intron|ADAMTS13_uc004cdz.3_Silent_p.C407C|ADAMTS13_uc004cds.1_Silent_p.C262C|ADAMTS13_uc004cdr.1_Intron	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	737					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CAGAGGCCTGCGTGCTCGAAC	0.657		NA											38	31					0	0	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138714065	138714065	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr9:138714065C>G	uc004cgr.3	-	11	2442	c.2442G>C	c.(2440-2442)ATG>ATC	p.M814I	CAMSAP1_uc004cgq.3_Missense_Mutation_p.M704I|CAMSAP1_uc010nbg.2_Missense_Mutation_p.M536I	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	814						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CAAAGCTGGTCATCTTCACGC	0.587		NA											18	101					0	0	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128887212	128887212	+	Silent	SNP	C	C	G			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chrX:128887212C>G	uc004eut.1	+	11	1339	c.1095C>G	c.(1093-1095)CTC>CTG	p.L365L		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	365					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						AGGCCCTCCTCAAGGCCAGCC	0.537		NA											33	51					0	0	0	0
ABL2	27	broad.mit.edu	37	1	179077623	179077632	+	Frame_Shift_Del	DEL	GAGTGGTTGG	GAGTGGTTGG	-			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr1:179077623_179077632delGAGTGGTTGG	uc001gmj.3	-	12	3057_3066	c.2770_2779delCCAACCACTC	c.(2770-2781)CCAACCACTCACfs	p.P924fs	ABL2_uc010pnf.1_Frame_Shift_Del_p.P821fs|ABL2_uc010png.1_Frame_Shift_Del_p.P800fs|ABL2_uc010pnh.1_Frame_Shift_Del_p.P903fs|ABL2_uc001gmg.3_Frame_Shift_Del_p.P806fs|ABL2_uc001gmi.3_Frame_Shift_Del_p.P909fs|ABL2_uc001gmh.3_Frame_Shift_Del_p.P888fs|ABL2_uc010pne.1_Frame_Shift_Del_p.P785fs	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	924_927	F-actin-binding (By similarity).|Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TTGTGGTTGTGAGTGGTTGGGAGGACGGGG	0.557		NA	T	ETV6	AML								8	81	---	---	---	---	NA	NA	NA	NA
OR4C11	219429	broad.mit.edu	37	11	55371152	55371152	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr11:55371152delT	uc010rii.1	-	1	698	c.698delA	c.(697-699)AAGfs	p.K233fs		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGAGAGAGCCTTTTTCTTCCC	0.418		NA											47	7	---	---	---	---	NA	NA	NA	NA
YY1	7528	broad.mit.edu	37	14	100705745	100705749	+	Frame_Shift_Del	DEL	GCGGT	GCGGT	-			TCGA-CV-5977-01A-11D-1683-08	TCGA-CV-5977-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	81f3c96a-54bb-4629-a64e-7c8dae66e11a	9289d7b1-076c-410c-a6d3-9e0e5df933fc	g.chr14:100705745_100705749delGCGGT	uc001ygy.1	+	1	644_648	c.164_168delGCGGT	c.(163-168)GGCGGTfs	p.G55fs		NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	55_56	Gly-rich.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				gaggacggcggcggtggcgaccacg	0.298		NA											10	12	---	---	---	---	NA	NA	NA	NA