Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NOS1AP	9722	broad.mit.edu	37	1	162124256	162124256	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:162124256G>A	uc001gbv.2	+	2	554	c.167G>A	c.(166-168)CGC>CAC	p.R56H	NOS1AP_uc010pkr.1_Missense_Mutation_p.R56H|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Missense_Mutation_p.R56H	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	56	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding	p.R56H(2)		lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCTGCCATGCGCCGGATACGG	0.607		NA											10	15					0	0	0	0
PIGC	5279	broad.mit.edu	37	1	172411036	172411036	+	Silent	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:172411036G>A	uc001gil.2	-	2	1008	c.727C>T	c.(727-729)CTA>TTA	p.L243L	PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_Silent_p.L243L|PIGC_uc001gio.2_Silent_p.L243L	NM_153747	NP_714969	Q92535	PIGC_HUMAN	phosphatidylinositol glycan, class C	243	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1						ATGGACAGTAGGCCTCCCACG	0.498		NA											44	30					0	0	0	0
ASPM	259266	broad.mit.edu	37	1	197112489	197112489	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:197112489A>G	uc001gtu.2	-	3	1150	c.893T>C	c.(892-894)CTT>CCT	p.L298P	ASPM_uc001gtv.2_Missense_Mutation_p.L298P|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	298					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GTTGGGGGTAAGACTAAGTTT	0.318		NA											38	63					0	0	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200827083	200827083	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr1:200827083G>A	uc001gvl.2	+	18	4636	c.4366G>A	c.(4366-4368)GCT>ACT	p.A1456T	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.A1445T|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.A1429T	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1456	CKK.					cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCACATACCCGCTAAAACTTT	0.373		NA											4	157					0	0	0	0
PFKP	5214	broad.mit.edu	37	10	3178006	3178006	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr10:3178006A>G	uc001igp.2	+	21	2237	c.2201A>G	c.(2200-2202)GAG>GGG	p.E734G	PFKP_uc001igq.2_Missense_Mutation_p.E726G|PFKP_uc009xhr.2_Missense_Mutation_p.E696G|PFKP_uc009xht.2_Missense_Mutation_p.E472G|PFKP_uc009xhu.2_Missense_Mutation_p.E240G	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	734					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding	p.E734G(1)		upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CCTGTGGCAGAGCTGAAGAAG	0.413		NA											26	6					0	0	0	0
KNDC1	85442	broad.mit.edu	37	10	135026377	135026377	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr10:135026377C>T	uc001llz.1	+	24	4395	c.4394C>T	c.(4393-4395)ACG>ATG	p.T1465M		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1465					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction			p.T1465M(1)		upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TACTTCCTGACGGAGTACAGC	0.657		NA											17	22					0	0	0	0
ODF3	113746	broad.mit.edu	37	11	198284	198284	+	Silent	SNP	A	A	G			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr11:198284A>G	uc001lob.2	+	4	690	c.396A>G	c.(394-396)CGA>CGG	p.R132R	ODF3_uc010qvk.1_Silent_p.R132R|ODF3_uc001loc.2_3'UTR	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3	132					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGCATTCCGAGTGGACAGCA	0.607		NA											7	19					0	0	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642976	1642976	+	Silent	SNP	A	A	C			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr11:1642976A>C	uc009ycy.1	-	3	573	c.486T>G	c.(484-486)GGT>GGG	p.G162G		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	176	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCCCTTGGAACCCCCACAGG	0.662		NA											8	45					0	0	0	0
MRPL17	63875	broad.mit.edu	37	11	6704488	6704488	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr11:6704488C>T	uc001men.2	-	1	145	c.40G>A	c.(40-42)GTA>ATA	p.V14I		NM_022061	NP_071344	Q9NRX2	RM17_HUMAN	mitochondrial ribosomal protein L17 precursor	14					translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CGGCGAAATACGCGGCCATGG	0.637		NA									OREG0020719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	33					0	0	0	0
MTMR2	8898	broad.mit.edu	37	11	95569371	95569371	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr11:95569371G>A	uc001pfu.2	-	14	1964	c.1711C>T	c.(1711-1713)CGC>TGC	p.R571C	MTMR2_uc001pfv.2_Missense_Mutation_p.R499C|MTMR2_uc001pfs.2_Missense_Mutation_p.R499C|MTMR2_uc001pft.2_Missense_Mutation_p.R499C	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	571	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TCTAGGTGGCGCATGCTGGCT	0.453		NA											5	291					0	0	0	0
MYL6B	140465	broad.mit.edu	37	12	56547746	56547746	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr12:56547746C>A	uc001sjs.2	+	2	171	c.44C>A	c.(43-45)CCC>CAC	p.P15H	MYL6B_uc009zoo.2_Missense_Mutation_p.P15H|MYL6B_uc001sjt.2_Missense_Mutation_p.P15H|MYL6B_uc001sju.1_Missense_Mutation_p.P15H	NM_002475	NP_002466	P14649	MYL6B_HUMAN	smooth muscle and non-muscle myosin alkali light	15					muscle filament sliding|skeletal muscle tissue development	cytosol|muscle myosin complex|unconventional myosin complex	calcium ion binding|motor activity|protein binding|structural constituent of muscle				0			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			CCAGCAGGGCCCTCCATCTCC	0.587		NA											3	37					0.004672	0.00495951	1	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr12:57485446T>C	uc001smz.2	+	2	1000	c.622T>C	c.(622-624)TTC>CTC	p.F208L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCGCCCCCCTTCTCCCCCCC	0.716		NA											5	30					0	0	0	0
RFX4	5992	broad.mit.edu	37	12	107113755	107113755	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr12:107113755C>A	uc001tlr.2	+	12	1222	c.1156C>A	c.(1156-1158)CAT>AAT	p.H386N	RFX4_uc001tls.2_Missense_Mutation_p.H395N|RFX4_uc001tlt.2_Missense_Mutation_p.H395N|RFX4_uc001tlv.2_Missense_Mutation_p.H292N	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	386	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding	p.H386N(1)		upper_aerodigestive_tract(1)	1						GGAGTTTGACCATCTCTTGGA	0.473		NA											16	39					8.28e-16	1.01e-15	1	0
OR4Q3	441669	broad.mit.edu	37	14	20216155	20216155	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr14:20216155G>A	uc010tkt.1	+	1	569	c.569G>A	c.(568-570)TGC>TAC	p.C190Y		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAGCTGGCCTGCATGGACACC	0.483		NA											17	53					0	0	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21762877	21762877	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr14:21762877C>T	uc001wag.2	+	2	127	c.127C>T	c.(127-129)CGG>TGG	p.R43W		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	43					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CAGGATGAACCGGGAGGAATT	0.408		NA											16	25					0	0	0	0
MAP1A	4130	broad.mit.edu	37	15	43821514	43821514	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr15:43821514C>A	uc001zrt.2	+	4	8310	c.7843C>A	c.(7843-7845)CCA>ACA	p.P2615T		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2615						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CAAGGCCAAGCCAGCGTCCCC	0.662		NA											25	22					2.8e-10	3.33e-10	1	0
CEP152	22995	broad.mit.edu	37	15	49097837	49097837	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr15:49097837C>A	uc001zwy.2	-	2	44	c.10G>T	c.(10-12)GAC>TAC	p.D4Y	CEP152_uc001zwz.2_Missense_Mutation_p.D4Y|CEP152_uc001zxa.1_Missense_Mutation_p.D4Y	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	4					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CTGCCAAAGTCTAATGACATG	0.398		NA											4	63					2.56e-06	2.97e-06	1	0
TEX9	374618	broad.mit.edu	37	15	56665657	56665657	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr15:56665657G>T	uc002adp.2	+	3	143	c.138G>T	c.(136-138)TTG>TTT	p.L46F	TEX9_uc002ado.1_Missense_Mutation_p.L46F|TEX9_uc010ugl.1_5'UTR|TEX9_uc002adq.1_5'UTR	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	46											0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		ATGCAGAATTGCAGGCAAAAA	0.269		NA											10	10					1.62e-10	1.94e-10	1	0
ZCCHC14	23174	broad.mit.edu	37	16	87445930	87445930	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr16:87445930T>G	uc002fjz.1	-	12	2013	c.1986A>C	c.(1984-1986)CAA>CAC	p.Q662H	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.Q438H	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	662					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding	p.Q662H(1)		upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GCACACTTATTTGCACATTAT	0.532		NA											127	84					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	28					0	0	0	0
KRT14	3861	broad.mit.edu	37	17	39740135	39740135	+	Silent	SNP	G	G	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:39740135G>T	uc002hxf.1	-	4	865	c.804C>A	c.(802-804)GTC>GTA	p.V268V	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Silent_p.V268V	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	268	Rod.|Linker 12.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				TCTCCACATTGACATCTCCAC	0.567		NA											31	44					1.75e-13	2.12e-13	1	0
MRPL27	51264	broad.mit.edu	37	17	48447949	48447949	+	Splice_Site	SNP	T	T	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:48447949T>A	uc002iqq.2	-	2	72	c.41_splice	c.e2-1	p.V14_splice	MRPL27_uc002iqr.2_Splice_Site_p.V14_splice|EME1_uc002iqs.1_5'Flank	NM_016504	NP_057588	Q9P0M9	RM27_HUMAN	mitochondrial ribosomal protein L27						translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;1.73e-07)			AGGATGTAACTGCAGAGAAAA	0.498		NA											5	147					0	0	0	0
CDC42EP4	23580	broad.mit.edu	37	17	71282113	71282113	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:71282113T>C	uc002jjn.2	-	2	674	c.527A>G	c.(526-528)GAC>GGC	p.D176G	CDC42EP4_uc002jjo.2_Missense_Mutation_p.D176G|CDC42EP4_uc002jjp.1_Missense_Mutation_p.D106G	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	176					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			GAGGAGGGGGTCAGGGGAATG	0.657		NA											25	28					0	0	0	0
RNF213	57674	broad.mit.edu	37	17	78326742	78326742	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr17:78326742C>A	uc002jyh.1	+	8	4748	c.4525C>A	c.(4525-4527)CTG>ATG	p.L1509M	uc002jyi.1_RNA|RNF213_uc010dhw.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTTCACAGGGCTGTGGCAGTC	0.562		NA											9	139					0.000673444	0.000749478	1	0
REXO1	57455	broad.mit.edu	37	19	1818781	1818781	+	Silent	SNP	G	G	A	rs138422554	by1000genomes	TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr19:1818781G>A	uc002lua.3	-	9	2921	c.2826C>T	c.(2824-2826)AAC>AAT	p.N942N	REXO1_uc010dsq.2_Silent_p.N251N|REXO1_uc010xgs.1_Translation_Start_Site|MIR1909_hsa-mir-1909|MI0008330_5'Flank|REXO1_uc010dsp.1_RNA	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	942						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGGTAGCCGTTCTCCTTGA	0.667		NA											11	19					0	0	0	0
ZNF414	84330	broad.mit.edu	37	19	8576734	8576734	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr19:8576734T>A	uc002mkf.2	-	5	759	c.641A>T	c.(640-642)GAC>GTC	p.D214V	ZNF414_uc002mke.3_Missense_Mutation_p.D214V|ZNF414_uc010dwf.2_Missense_Mutation_p.D203V	NM_032370	NP_115746	Q96IQ9	ZN414_HUMAN	zinc finger protein 414 isoform 2	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGGCTCTCGGTCCAGGGCCGG	0.746		NA											5	3					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168105632	168105632	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr2:168105632A>G	uc002udx.2	+	8	7748	c.7730A>G	c.(7729-7731)AAT>AGT	p.N2577S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.N2402S|XIRP2_uc010fpq.2_Missense_Mutation_p.N2355S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2402					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAAAGCCAAAATCAACACATA	0.343		NA											51	55					0	0	0	0
SGK2	10110	broad.mit.edu	37	20	42208658	42208658	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr20:42208658A>G	uc002xkv.2	+	11	1295	c.1076A>G	c.(1075-1077)GAC>GGC	p.D359G	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.D299G|SGK2_uc010ggm.2_Missense_Mutation_p.D299G|SGK2_uc002xks.2_Missense_Mutation_p.D298G|SGK2_uc002xku.2_Missense_Mutation_p.D299G	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	359	AGC-kinase C-terminal.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity	p.D359G(1)		lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AACTGGGATGACCTGTACCAC	0.383		NA											19	28					0	0	0	0
TNFRSF6B	8771	broad.mit.edu	37	20	62328365	62328365	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr20:62328365G>A	uc002yfy.2	+	5	679	c.245G>A	c.(244-246)TGG>TAG	p.W82*	RTEL1_uc011abd.1_3'UTR|RTEL1_uc011abe.1_3'UTR|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_3'UTR|TNFRSF6B_uc002yfz.2_Nonsense_Mutation_p.W82*	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	82	TNFR-Cys 2.				anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			ACGCAGTTCTGGAACTACCTA	0.697		NA											5	14					0	0	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047662	46047662	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr21:46047662T>A	uc002zfp.3	+	1	623	c.574T>A	c.(574-576)TGC>AGC	p.C192S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	192	25 X 5 AA repeats of C-C-X(3).|19.					keratin filament					0						TAAGCCTGTCTGCTGCAAACC	0.597		NA											9	225					0	0	0	0
DOCK3	1795	broad.mit.edu	37	3	51198105	51198105	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr3:51198105G>T	uc011bds.1	+	12	1032	c.1009G>T	c.(1009-1011)GAA>TAA	p.E337*		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	337						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGTAAAGGAAGAAAAGGATTT	0.438		NA											5	7					0.000602214	0.000675655	1	0
CLDN18	51208	broad.mit.edu	37	3	137749947	137749947	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr3:137749947G>T	uc003ero.1	+	5	803	c.750G>T	c.(748-750)GAG>GAT	p.E250D	CLDN18_uc003erp.1_Missense_Mutation_p.E250D|CLDN18_uc010hue.1_Missense_Mutation_p.E206D	NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	250	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity	p.E250D(2)		upper_aerodigestive_tract(1)|ovary(1)	2						CAGAGGACGAGGTACAATCTT	0.517		NA											46	66					3.71e-28	4.61e-28	1	0
FGB	2244	broad.mit.edu	37	4	155490819	155490819	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr4:155490819C>T	uc003ioa.3	+	7	1151	c.1112C>T	c.(1111-1113)TCA>TTA	p.S371L	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.S309L|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.S152L	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	371	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.S371L(1)		ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TACCAGATCTCAGTGAACAAA	0.448		NA											21	42					0	0	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581481	140581481	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr5:140581481C>T	uc003liy.2	+	1	2134	c.2134C>T	c.(2134-2136)CGG>TGG	p.R712W	PCDHB11_uc011daj.1_Missense_Mutation_p.R347W	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	712	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTGGCGGTGCGGCTGTGCAG	0.682		NA											5	105					0	0	0	0
GCNT2	2651	broad.mit.edu	37	6	10529618	10529618	+	Silent	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:10529618G>A	uc010joo.2	+	3	1025	c.474G>A	c.(472-474)TCG>TCA	p.S158S	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Silent_p.S157S|GCNT2_uc010jon.2_Silent_p.S157S	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	158	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AGAAGGAGTCGGTTGTCTATG	0.532		NA											15	21					0	0	0	0
NCR3	259197	broad.mit.edu	37	6	31557388	31557388	+	Silent	SNP	A	A	C			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:31557388A>C	uc003nuv.2	-	3	675	c.411T>G	c.(409-411)GGT>GGG	p.G137G	NCR3_uc003nuw.2_Silent_p.G137G|NCR3_uc003nux.1_Silent_p.G137G	NM_147130	NP_667341	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	137	Helical; (Potential).				cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						GGAGGACTGTACCAGCCCCTA	0.582		NA											6	20					0	0	0	0
EGFL8	80864	broad.mit.edu	37	6	32134741	32134741	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:32134741G>T	uc003oab.1	+	5	447	c.389G>T	c.(388-390)TGC>TTC	p.C130F	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.C130F	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	130	EGF-like 1.					extracellular region|integral to membrane	calcium ion binding				0						CCTGACCAGTGCGAGTGCGCC	0.652		NA											4	95					0.00024832	0.000280887	1	0
ECT2L	345930	broad.mit.edu	37	6	139167808	139167808	+	Silent	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:139167808G>A	uc003qif.1	+	6	1000	c.897G>A	c.(895-897)GCG>GCA	p.A299A	ECT2L_uc011edq.1_Silent_p.A230A	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	299					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						GGATTCCTGCGTATGAGGTAG	0.383		NA											104	145					0	0	0	0
SHPRH	257218	broad.mit.edu	37	6	146276439	146276439	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr6:146276439C>T	uc003qlf.2	-	2	419	c.20G>A	c.(19-21)CGT>CAT	p.R7H	SHPRH_uc003qld.2_Missense_Mutation_p.R7H|SHPRH_uc003qle.2_Missense_Mutation_p.R7H|SHPRH_uc003qlg.1_Translation_Start_Site|SHPRH_uc003qlj.1_Missense_Mutation_p.R7H|SHPRH_uc003qlk.1_Missense_Mutation_p.R7H	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	7					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGGAGGAGCACGTTTCCGTCG	0.428		NA											42	55					0	0	0	0
ANK1	286	broad.mit.edu	37	8	41530033	41530033	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr8:41530033C>G	uc003xok.2	-	38	5019	c.4935G>C	c.(4933-4935)AGG>AGC	p.R1645S	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.R1645S|ANK1_uc003xoj.2_Missense_Mutation_p.R1645S|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Missense_Mutation_p.R1686S	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1645	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTCTTCTGACCTCTGACCTT	0.537		NA											7	177					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139164859	139164859	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chr8:139164859T>A	uc003yuy.2	-	13	2030	c.1859A>T	c.(1858-1860)AAG>ATG	p.K620M	FAM135B_uc003yux.2_Missense_Mutation_p.K521M|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.K182M|FAM135B_uc003yvb.2_Missense_Mutation_p.K182M	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	620										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATCTATTCCCTTTCCTAGAGT	0.473		NA								HNSCC(54;0.14)			39	88					0	0	0	0
IL3RA	3563	broad.mit.edu	37	X	1484134	1484134	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chrX:1484134C>T	uc004cps.2	+	9	1212	c.863C>T	c.(862-864)CCC>CTC	p.P288L	IL3RA_uc011mhd.1_Missense_Mutation_p.P210L	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	288	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGGAGCACCCCCCAGCGCTTC	0.373		NA											15	36					0	0	0	0
BEND2	139105	broad.mit.edu	37	X	18195875	18195875	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chrX:18195875G>A	uc004cyj.3	-	10	1598	c.1444C>T	c.(1444-1446)CCA>TCA	p.P482S	BEND2_uc010nfb.2_Missense_Mutation_p.P391S	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	482										ovary(3)|kidney(1)|central_nervous_system(1)	5						TTTCTTTTTGGATCACCAAGA	0.378		NA											14	107					0	0	0	0
TCEAL3	85012	broad.mit.edu	37	X	102864204	102864204	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-5979-01A-11D-1683-08	TCGA-CV-5979-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c2c31b58-c5b3-4fc3-be99-b978d2961f86	360e4ed7-d780-4769-98e9-3dd07468d2b0	g.chrX:102864204G>A	uc004ekq.2	+	3	474	c.212G>A	c.(211-213)AGG>AAG	p.R71K	TCEAL3_uc004ekr.2_Missense_Mutation_p.R71K	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	71	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AAGCAGGGCAGGTCCGAAGGT	0.398		NA											3	67					0	0	0	0