Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
AHDC1	27245	broad.mit.edu	37	1	27874105	27874105	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:27874105G>C	uc009vsy.2	-	6	5491	c.4522C>G	c.(4522-4524)CCA>GCA	p.P1508A	AHDC1_uc009vsz.1_Missense_Mutation_p.P1508A	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1508							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GTGGCTGGTGGGCTAGCCAGG	0.711		NA											3	8					0	0	0	0
C1orf103	55791	broad.mit.edu	37	1	111490996	111490996	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:111490996G>A	uc001eaa.2	-	4	2151	c.1895C>T	c.(1894-1896)GCA>GTA	p.A632V	C1orf103_uc001dzz.2_Missense_Mutation_p.A96V|C1orf103_uc001eab.2_Missense_Mutation_p.A96V|C1orf103_uc001eac.1_Missense_Mutation_p.A95V	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		ATTAGTTTTTGCTTTTCTTTT	0.343		NA											11	22					0	0	0	0
NBPF7	343505	broad.mit.edu	37	1	120382017	120382017	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:120382017C>G	uc010oxk.1	-	5	1249	c.628G>C	c.(628-630)GAG>CAG	p.E210Q		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	210	NBPF 1.					cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		TTCTGCTCCTCCCTGATGAGC	0.502		NA											23	158					0	0	0	0
APOA1BP	128240	broad.mit.edu	37	1	156563322	156563322	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:156563322C>T	uc001fph.2	+	5	678	c.639C>T	c.(637-639)CCC>CCT	p.P213P	APOA1BP_uc001fpg.2_Silent_p.P213P|APOA1BP_uc001fpi.2_Missense_Mutation_p.H195Y|APOA1BP_uc001fpj.2_Silent_p.P130P|APOA1BP_uc001fpk.2_Silent_p.P110P|APOA1BP_uc010php.1_Silent_p.P110P	NM_144772	NP_658985	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein precursor	213	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCACTGTGCCCATTGCCAGCA	0.577		NA											5	46					0	0	0	0
METTL13	51603	broad.mit.edu	37	1	171756952	171756952	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:171756952C>A	uc001ghz.2	+	4	1538	c.1191C>A	c.(1189-1191)GAC>GAA	p.D397E	METTL13_uc001gia.2_Missense_Mutation_p.D311E|METTL13_uc001gib.2_Missense_Mutation_p.D241E|METTL13_uc010pml.1_Missense_Mutation_p.D396E	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	397							methyltransferase activity|protein binding			kidney(1)	1						TGAGCGGTGACTATGTCATTG	0.552		NA											3	33					0.004672	0.00516058	1	0
C1orf125	126859	broad.mit.edu	37	1	179460728	179460728	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:179460728T>G	uc001gmo.2	+	19	2274	c.2147T>G	c.(2146-2148)ATG>AGG	p.M716R	C1orf125_uc009wxg.2_RNA|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.M716R|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	716											0						CTGATTTTAATGATACCCAAC	0.363		NA											29	57					0	0	0	0
ACTN2	88	broad.mit.edu	37	1	236924422	236924422	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr1:236924422C>T	uc001hyf.2	+	20	2679	c.2475C>T	c.(2473-2475)ACC>ACT	p.T825T	ACTN2_uc001hyg.2_Silent_p.T617T|ACTN2_uc009xgi.1_Silent_p.T825T|ACTN2_uc010pxu.1_Silent_p.T514T|ACTN2_uc001hyh.2_Silent_p.T513T	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	825					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGGCTGACACCGACACTGCCG	0.537		NA											27	34					0	0	0	0
PRKG1	5592	broad.mit.edu	37	10	53564372	53564372	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr10:53564372T>A	uc001jjm.2	+	4	769	c.575T>A	c.(574-576)ATT>AAT	p.I192N	PRKG1_uc001jjn.2_Missense_Mutation_p.I207N|PRKG1_uc001jjo.2_Missense_Mutation_p.I207N	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	192	cGMP 1.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		CTCTGGGCCATTGATCGACAA	0.343		NA											12	36					0	0	0	0
GFRA1	2674	broad.mit.edu	37	10	117823944	117823944	+	Silent	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr10:117823944G>A	uc001lcj.2	-	11	2061	c.1363C>T	c.(1363-1365)CTG>TTG	p.L455L	GFRA1_uc001lci.2_Silent_p.L450L|GFRA1_uc009xyr.2_Silent_p.L450L	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	455					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		AGGGTGGACAGAGCGGTTACC	0.428		NA											12	36					0	0	0	0
OR4C11	219429	broad.mit.edu	37	11	55371281	55371281	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:55371281G>A	uc010rii.1	-	1	569	c.569C>T	c.(568-570)ACT>ATT	p.T190I		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GATCATGTAAGTGTCCATGCA	0.398		NA											60	46					0	0	0	0
RPS6KB2	6199	broad.mit.edu	37	11	67200832	67200832	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr11:67200832C>T	uc001old.2	+	10	902	c.820C>T	c.(820-822)CGG>TGG	p.R274W	RPS6KB2_uc001olf.2_Missense_Mutation_p.R74W|RPS6KB2_uc001olg.2_Missense_Mutation_p.R274W|RPS6KB2_uc009yrq.2_Missense_Mutation_p.R74W|RPS6KB2_uc001ole.2_RNA|RPS6KB2_uc001olh.2_Intron|RPS6KB2_uc009yrr.2_Missense_Mutation_p.R105W	NM_003952	NP_003943	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide	274	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|stomach(1)|lung(1)|salivary_gland(1)	7			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGCAGAGAACCGGAAGAAAAC	0.632		NA											11	78					0	0	0	0
CUX2	23316	broad.mit.edu	37	12	111652070	111652070	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr12:111652070C>A	uc001tsa.1	+	2	283	c.130C>A	c.(130-132)CAT>AAT	p.H44N	CUX2_uc001tsb.1_Missense_Mutation_p.H99N	NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	44						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TTCTCATAAACATTTAATTGA	0.363		NA											4	101					0.00024832	0.000287439	1	0
STRC	161497	broad.mit.edu	37	15	43900125	43900126	+	Missense_Mutation	DNP	GT	GT	TC			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:43900125_43900126GT>TC	uc001zsf.2	-	18	3807_3808	c.3729_3730AC>GA	c.(3727-3732)GAACCA>GAGACA	p.P1244T	STRC_uc010bdl.2_Missense_Mutation_p.P471T|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1244					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GTCCATTCTGGTTCTGGCATTG	0.535		NA											22	95					0	0	0	0
SCG3	29106	broad.mit.edu	37	15	51981445	51981445	+	Silent	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:51981445A>G	uc002abh.2	+	6	978	c.570A>G	c.(568-570)GAA>GAG	p.E190E	SCG3_uc010ufz.1_5'UTR	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	190					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		ATACACTGGAAGATGAAGTAG	0.368		NA											25	43					0	0	0	0
ZNF609	23060	broad.mit.edu	37	15	64967739	64967739	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr15:64967739G>A	uc002ann.2	+	4	2686	c.2686G>A	c.(2686-2688)GAG>AAG	p.E896K		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	896						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCAAGGCTTTGAGAGTTACTA	0.507		NA											5	97					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	64984710	64984710	+	Silent	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr16:64984710G>A	uc002eoi.2	-	12	2288	c.1854C>T	c.(1852-1854)GGC>GGT	p.G618G	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.G618G|CDH11_uc010vin.1_Silent_p.G492G	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	618	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CGATCAGGGCGCCTGTGCTCA	0.632		NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			9	27					0	0	0	0
CES2	8824	broad.mit.edu	37	16	66974469	66974469	+	Silent	SNP	G	G	A	rs150055059		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr16:66974469G>A	uc002eqr.2	+	5	1879	c.879G>A	c.(877-879)GCG>GCA	p.A293A	CES2_uc002eqq.2_Silent_p.A293A|CES2_uc002eqs.2_Silent_p.A136A	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	229					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		GCGAGTCTGCGGGTGGCACGA	0.607		NA											35	70					0	0	0	0
KIAA1012	22878	broad.mit.edu	37	18	29432467	29432467	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr18:29432467G>A	uc002kxc.3	-	24	3867	c.3503C>T	c.(3502-3504)GCG>GTG	p.A1168V	KIAA1012_uc002kxb.3_Missense_Mutation_p.A1114V|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1168					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						CTGTGTGGCCGCTAAAAAACA	0.318		NA											4	186					0	0	0	0
MUC16	94025	broad.mit.edu	37	19	9088749	9088749	+	Silent	SNP	G	G	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:9088749G>C	uc002mkp.2	-	1	3270	c.3066C>G	c.(3064-3066)CTC>CTG	p.L1022L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1022	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTCTGTTGTGAGGATGGTTG	0.473		NA											9	144					0	0	0	0
GCDH	2639	broad.mit.edu	37	19	13004312	13004312	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:13004312G>A	uc002mvq.2	+	6	427	c.350G>A	c.(349-351)GGG>GAG	p.G117E	GCDH_uc010xms.1_Missense_Mutation_p.G84E|GCDH_uc002mvp.2_Missense_Mutation_p.G117E|GCDH_uc010xmt.1_5'UTR|GCDH_uc010xmu.1_Missense_Mutation_p.G73E	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	117					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						GGCTGTGCTGGGGTTTCGTCT	0.597		NA											25	27					0	0	0	0
CIB3	117286	broad.mit.edu	37	19	16284287	16284287	+	Splice_Site	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:16284287G>A	uc002nds.2	-	1	1	c.1_splice	c.e1-1	p.M1_splice	CIB3_uc010eae.2_Splice_Site|CIB3_uc010eaf.2_Splice_Site|CIB3_uc010eag.2_Splice_Site_p.M1_splice	NM_054113	NP_473454	Q96Q77	CIB3_HUMAN	DNA-dependent protein kinase catalytic								calcium ion binding			ovary(1)	1						TGTTGCCCATGGTGTGAACCA	0.587		NA											3	86					0	0	0	0
ELL	8178	broad.mit.edu	37	19	18555654	18555654	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:18555654T>A	uc002njh.2	-	12	1846	c.1774A>T	c.(1774-1776)AAG>TAG	p.K592*	ELL_uc010ebq.2_Nonsense_Mutation_p.K535*|ELL_uc002njg.2_Nonsense_Mutation_p.K459*	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	592					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		CAGCGGTGCTTCTCCTGGCTG	0.642		NA	T	MLL	AL								16	41					0	0	0	0
CILP2	148113	broad.mit.edu	37	19	19654666	19654666	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:19654666T>G	uc002nmv.3	+	8	1397	c.1312T>G	c.(1312-1314)TGC>GGC	p.C438G	CILP2_uc002nmw.3_Missense_Mutation_p.C444G	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	438						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CTCCCGCTGCTGCTCTGTGCG	0.682		NA											33	39					0	0	0	0
RYR1	6261	broad.mit.edu	37	19	38979817	38979817	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:38979817G>A	uc002oit.2	+	35	5678	c.5548G>A	c.(5548-5550)GTG>ATG	p.V1850M	RYR1_uc002oiu.2_Missense_Mutation_p.V1850M	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1850	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGTCCTGTAGGTGATGGGCAT	0.443		NA											11	9					0	0	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45716536	45716536	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:45716536G>A	uc002pay.1	-	10	1062	c.1021C>T	c.(1021-1023)CGG>TGG	p.R341W		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	341										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		TCCAGGTCCCGGGCCACGGCC	0.657		NA											9	24					0	0	0	0
ZNF880	400713	broad.mit.edu	37	19	52887785	52887785	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:52887785C>T	uc002pzc.2	+	4	1001	c.952C>T	c.(952-954)CAT>TAT	p.H318Y		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	318	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TCAGAAAATTCATAGTGGAGA	0.413		NA											19	13					0	0	0	0
ZNF835	90485	broad.mit.edu	37	19	57176313	57176313	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:57176313G>A	uc010ygo.1	-	2	320	c.320C>T	c.(319-321)GCG>GTG	p.A107V	ZNF835_uc010ygn.1_Missense_Mutation_p.A85V	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						CTCCCCAGGCGCGCTGCACCT	0.647		NA											10	17					0	0	0	0
ASAP2	8853	broad.mit.edu	37	2	9515038	9515038	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr2:9515038G>A	uc002qzh.2	+	17	2051	c.1711G>A	c.(1711-1713)GAT>AAT	p.D571N	ASAP2_uc002qzi.2_Missense_Mutation_p.D571N	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	571					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						TGATGGTGTGGATCTTACGGA	0.388		NA											23	39					0	0	0	0
TMEFF2	23671	broad.mit.edu	37	2	192922459	192922459	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr2:192922459G>A	uc002utc.2	-	5	876	c.482C>T	c.(481-483)ACC>ATC	p.T161I		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	161	Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			AATATCACAGGTGGATGTCTC	0.378		NA											26	50					0	0	0	0
KIF3B	9371	broad.mit.edu	37	20	30897975	30897975	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr20:30897975G>T	uc002wxq.2	+	2	562	c.395G>T	c.(394-396)CGA>CTA	p.R132L	KIF3B_uc010ztv.1_Missense_Mutation_p.R132L|KIF3B_uc010ztw.1_Missense_Mutation_p.R132L	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	132	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CACATCTCTCGATCCCAGAAT	0.463		NA											5	102					1.64e-10	2.05e-10	1	0
MAPK11	5600	broad.mit.edu	37	22	50703752	50703752	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr22:50703752T>C	uc003bkr.2	-	11	1071	c.1013A>G	c.(1012-1014)AAG>AGG	p.K338R	MAPK11_uc010hax.2_Missense_Mutation_p.K160R|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	338					activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ATGCTCACCCTTCCACTCCTC	0.637		NA											3	63					0	0	0	0
SACM1L	22908	broad.mit.edu	37	3	45776796	45776796	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:45776796G>A	uc003cos.2	+	14	1374	c.1170G>A	c.(1168-1170)ATG>ATA	p.M390I	SACM1L_uc011bag.1_Missense_Mutation_p.M287I|SACM1L_uc011bah.1_Missense_Mutation_p.M324I|SACM1L_uc003cot.2_Missense_Mutation_p.M33I	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	390	SAC.					Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GCAATTGCATGGATTGTCTAG	0.408		NA											19	53					0	0	0	0
CELSR3	1951	broad.mit.edu	37	3	48699612	48699613	+	Missense_Mutation	DNP	AC	AC	TT			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:48699612_48699613AC>TT	uc003cul.2	-	1	736_737	c.455_456GT>AA	c.(454-456)AGT>AAA	p.S152K	CELSR3_uc003cuf.1_Missense_Mutation_p.S222K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	152	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGGTGACAGACTACCTCTTTG	0.629		NA											45	85					0	0	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540270	169540270	+	Silent	SNP	C	C	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr3:169540270C>G	uc003fgb.2	+	1	561	c.561C>G	c.(559-561)CTC>CTG	p.L187L		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	187	LRR 7.										0						TCTGTGTTCTCTACACCCTGG	0.488		NA											4	124					0	0	0	0
STIM2	57620	broad.mit.edu	37	4	27003875	27003875	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:27003875C>T	uc003gsh.3	+	6	1139	c.923C>T	c.(922-924)ACA>ATA	p.T308I	STIM2_uc003gsg.3_Missense_Mutation_p.T308I|STIM2_uc010iex.2_Missense_Mutation_p.T308I|STIM2_uc010iey.2_5'Flank	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	221	Helical; (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				TTTATCCTCACAGTTTCTATA	0.343		NA											3	37					0	0	0	0
TEC	7006	broad.mit.edu	37	4	48169913	48169913	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:48169913C>T	uc003gxz.2	-	7	644	c.553G>A	c.(553-555)GTA>ATA	p.V185I		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	185	SH3.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						TACATGGCTACAACGATTTCT	0.393		NA											6	97					0	0	0	0
GNRHR	2798	broad.mit.edu	37	4	68610290	68610290	+	Silent	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:68610290G>A	uc003hdn.2	-	2	2489	c.738C>T	c.(736-738)CCC>CCT	p.P246P	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_Missense_Mutation_p.P204S	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	246	Cytoplasmic (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	ACATACCGTGGGGGTCCTGAT	0.388		NA											20	26					0	0	0	0
ANKRD17	26057	broad.mit.edu	37	4	73963791	73963791	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:73963791T>G	uc003hgp.2	-	26	5137	c.5020A>C	c.(5020-5022)AAA>CAA	p.K1674Q	ANKRD17_uc003hgo.2_Missense_Mutation_p.K1561Q|ANKRD17_uc003hgq.2_Missense_Mutation_p.K1423Q|ANKRD17_uc003hgr.2_Missense_Mutation_p.K1673Q	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1674	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGAACTAACTTTATTGAAGCC	0.333		NA											28	50					0	0	0	0
SMARCA5	8467	broad.mit.edu	37	4	144467996	144467996	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:144467996A>G	uc003ijg.2	+	20	3050	c.2588A>G	c.(2587-2589)GAT>GGT	p.D863G		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	863	SANT 1.				CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					TGGGGTCGTGATGATATTGAA	0.338		NA											15	31					0	0	0	0
TRIM2	23321	broad.mit.edu	37	4	154249705	154249705	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr4:154249705C>T	uc003ing.2	+	11	2166	c.1965C>T	c.(1963-1965)TTC>TTT	p.F655F	TRIM2_uc003inh.2_Silent_p.F682F	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	655						cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		AAGGAGAATTCATGTTGAAGT	0.343		NA											15	30					0	0	0	0
ZNF608	57507	broad.mit.edu	37	5	123977043	123977043	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:123977043C>T	uc003ktq.1	-	7	4475	c.4352G>A	c.(4351-4353)CGC>CAC	p.R1451H	ZNF608_uc003ktr.1_Intron|ZNF608_uc003ktp.1_Missense_Mutation_p.R146H	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1451						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GGGGGAGTGGCGATCCCTTTC	0.557		NA											4	76					0	0	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788902	140788902	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:140788902G>C	uc003lkj.1	+	1	1133	c.1133G>C	c.(1132-1134)GGA>GCA	p.G378A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.G378A	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	378	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATTTCGGAGGAAATGGAGAA	0.413		NA											19	21					0	0	0	0
NMUR2	56923	broad.mit.edu	37	5	151784417	151784417	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr5:151784417G>T	uc003luv.2	-	1	424	c.258C>A	c.(256-258)AGC>AGA	p.S86R		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	86	Helical; Name=2; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AGACCGCCAGGCTGAAGAGGT	0.572		NA											30	68					2e-19	2.52e-19	1	0
DSP	1832	broad.mit.edu	37	6	7571657	7571657	+	Silent	SNP	C	C	T	rs139095230		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:7571657C>T	uc003mxp.1	+	14	2022	c.1743C>T	c.(1741-1743)GCC>GCT	p.A581A	DSP_uc003mxq.1_Silent_p.A581A	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	581	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGACGATAGCCGACCTTGAGT	0.443		NA											6	237					0	0	0	0
IP6K3	117283	broad.mit.edu	37	6	33690555	33690555	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:33690555T>C	uc010jvf.2	-	7	1711	c.1175A>G	c.(1174-1176)TAT>TGT	p.Y392C	IP6K3_uc003ofb.2_Missense_Mutation_p.Y392C	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	392					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						GCCAAAAATATAGCCAGGGTC	0.483		NA											29	82					0	0	0	0
KIAA1009	22832	broad.mit.edu	37	6	84862866	84862866	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:84862866C>A	uc010kbp.2	-	23	3124	c.3027G>T	c.(3025-3027)GAG>GAT	p.E1009D	KIAA1009_uc003pkj.3_Missense_Mutation_p.E933D|KIAA1009_uc003pki.3_Missense_Mutation_p.E395D	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	1009	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CAAGTAGCTGCTCCTGCTGCT	0.428		NA											5	14					0.00116845	0.00133424	1	0
ZNF292	23036	broad.mit.edu	37	6	87968193	87968193	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:87968193A>G	uc003plm.3	+	8	4887	c.4846A>G	c.(4846-4848)AGA>GGA	p.R1616G		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TCAGAACACAAGATCCAGTCA	0.393		NA											7	21					0	0	0	0
FRK	2444	broad.mit.edu	37	6	116288718	116288718	+	Silent	SNP	T	T	C			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:116288718T>C	uc003pwi.1	-	4	1242	c.795A>G	c.(793-795)AAA>AAG	p.K265K		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	265	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TCGCACCTGGTTTTAATGTTT	0.403		NA											9	126					0	0	0	0
UTRN	7402	broad.mit.edu	37	6	145093097	145093097	+	Silent	SNP	A	A	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:145093097A>G	uc003qkt.2	+	58	8642	c.8550A>G	c.(8548-8550)CAA>CAG	p.Q2850Q		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2850	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AACTCTTTCAATCCCTTGGTA	0.249		NA											17	44					0	0	0	0
ARID1B	57492	broad.mit.edu	37	6	157502235	157502235	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr6:157502235C>G	uc003qqn.2	+	12	3366	c.3214C>G	c.(3214-3216)CTG>GTG	p.L1072V	ARID1B_uc003qqo.2_Missense_Mutation_p.L1032V|ARID1B_uc003qqp.2_Missense_Mutation_p.L1019V|ARID1B_uc010kjl.2_Missense_Mutation_p.L217V	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1077	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TGTCTCAAGTCTGCCTGCCGT	0.577		NA											7	21					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100677648	100677648	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr7:100677648C>A	uc003uxp.1	+	3	3004	c.2951C>A	c.(2950-2952)CCA>CAA	p.P984Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	984	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|14.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGAACGACTCCATTAACAAGC	0.507		NA											92	160					1.01e-35	1.29e-35	1	0
OR2A14	135941	broad.mit.edu	37	7	143826964	143826964	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr7:143826964C>T	uc011kua.1	+	1	759	c.759C>T	c.(757-759)AGC>AGT	p.S253S		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TCTTTGGCAGCGCCATTGTCA	0.577		NA											4	136					0	0	0	0
PDGFRL	5157	broad.mit.edu	37	8	17478590	17478590	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:17478590G>T	uc003wxr.2	+	3	445	c.384G>T	c.(382-384)TTG>TTT	p.L128F		NM_006207	NP_006198	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	128	Ig-like C2-type 1.					extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity				0				Colorectal(111;0.0752)		ACGGCCAGTTGACTCTGGTCA	0.567		NA											13	35					1.05e-09	1.31e-09	1	0
POLR3D	661	broad.mit.edu	37	8	22107661	22107661	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:22107661G>A	uc003xbl.2	+	8	1078	c.995G>A	c.(994-996)CGC>CAC	p.R332H	POLR3D_uc003xbm.2_Missense_Mutation_p.R332H|POLR3D_uc011kze.1_RNA	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	332					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CTACTCATCCGCAAGTCTGGA	0.562		NA											4	56					0	0	0	0
CHRNA2	1135	broad.mit.edu	37	8	27327422	27327422	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:27327422C>T	uc010lur.2	-	3	759	c.150G>A	c.(148-150)CCG>CCA	p.P50P	CHRNA2_uc011lal.1_Silent_p.P50P|CHRNA2_uc010lus.2_5'UTR	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	50	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AGCCTCCCTGCGGCAATGCCG	0.612		NA											5	84					0	0	0	0
LRRC67	286187	broad.mit.edu	37	8	67929968	67929968	+	Silent	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:67929968G>T	uc003xxc.2	-	2	160	c.15C>A	c.(13-15)ACC>ACA	p.T5T		NM_001013626	NP_001013648	Q7Z4L9	LRC67_HUMAN	leucine rich repeat containing 67	5											0						TTAGATCCAAGGTCAGTCGAA	0.338		NA											14	56					0.000219431	0.000257527	1	0
FABP4	2167	broad.mit.edu	37	8	82392828	82392828	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:82392828C>G	uc003ycd.2	-	2	150	c.79G>C	c.(79-81)GGC>CGC	p.G27R		NM_001442	NP_001433	P15090	FABP4_HUMAN	fatty acid binding protein 4, adipocyte	27	Nuclear localization signal (By similarity).				triglyceride catabolic process	cytoplasm|nucleus|soluble fraction	fatty acid binding|protein binding|transporter activity			breast(1)	1			Epithelial(68;0.213)			GTGGCAAAGCCCACTCCTACA	0.423		NA											3	54					0	0	0	0
SYBU	55638	broad.mit.edu	37	8	110587412	110587412	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:110587412C>T	uc003ynj.3	-	7	1878	c.1715G>A	c.(1714-1716)CGC>CAC	p.R572H	SYBU_uc003yni.3_Missense_Mutation_p.R569H|SYBU_uc003ynk.3_Missense_Mutation_p.R453H|SYBU_uc010mco.2_Missense_Mutation_p.R571H|SYBU_uc003ynl.3_Missense_Mutation_p.R571H|SYBU_uc010mcp.2_Missense_Mutation_p.R572H|SYBU_uc010mcq.2_Missense_Mutation_p.R572H|SYBU_uc003yno.3_Missense_Mutation_p.R453H|SYBU_uc010mcr.2_Missense_Mutation_p.R572H|SYBU_uc003ynm.3_Missense_Mutation_p.R571H|SYBU_uc003ynn.3_Missense_Mutation_p.R571H|SYBU_uc010mcs.2_Missense_Mutation_p.R453H|SYBU_uc010mct.2_Missense_Mutation_p.R572H|SYBU_uc010mcu.2_Missense_Mutation_p.R571H|SYBU_uc003ynp.3_Missense_Mutation_p.R504H|SYBU_uc010mcv.2_Missense_Mutation_p.R572H|SYBU_uc003ynh.3_Missense_Mutation_p.R366H|SYBU_uc011lhw.1_Missense_Mutation_p.R442H	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	572						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TCTCATGAGGCGGTTTGCATG	0.542		NA											19	37					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113933928	113933928	+	Missense_Mutation	SNP	C	C	T	rs140758499		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:113933928C>T	uc003ynu.2	-	10	1720	c.1561G>A	c.(1561-1563)GCA>ACA	p.A521T	CSMD3_uc003ynt.2_Missense_Mutation_p.A481T|CSMD3_uc011lhx.1_Missense_Mutation_p.A417T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	521	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGCTCTTTGCGCCCTGTAGG	0.383		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	53					0	0	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144295190	144295190	+	Silent	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr8:144295190G>T	uc003yxu.1	+	1	123	c.48G>T	c.(46-48)CGG>CGT	p.R16R		NM_178172	NP_835466	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high	16					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity				0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGTGCGGGCGGCCAGGTGCGG	0.672		NA											3	23					0.00909568	0.00985365	1	0
ZNF658	26149	broad.mit.edu	37	9	40774007	40774007	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:40774007G>T	uc004abs.2	-	5	1420	c.1268C>A	c.(1267-1269)TCA>TAA	p.S423*	ZNF658_uc010mmm.1_Nonsense_Mutation_p.S423*|ZNF658_uc010mmn.1_Nonsense_Mutation_p.S423*	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	423	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ATGTGAACTTGAACAAAAGGA	0.398		NA											6	181					0.00116845	0.00133424	1	0
ABCA1	19	broad.mit.edu	37	9	107593339	107593339	+	Missense_Mutation	SNP	G	G	A	rs2853574		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:107593339G>A	uc004bcl.2	-	14	2072	c.1759C>T	c.(1759-1761)CGG>TGG	p.R587W		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	587	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGACGTACCGCATGTCCTCA	0.502		NA											4	94					0	0	0	0
UAP1L1	91373	broad.mit.edu	37	9	139974547	139974547	+	Silent	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:139974547C>T	uc010ncb.2	+	6	1163	c.1131C>T	c.(1129-1131)AAC>AAT	p.N377N	UAP1L1_uc004cla.3_Silent_p.N254N	NM_207309	NP_997192	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like	377							nucleotidyltransferase activity			ovary(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		TAAAACCGAACGGGATAAAGA	0.473		NA											51	59					0	0	0	0
CXorf22	170063	broad.mit.edu	37	X	35938046	35938046	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:35938046C>T	uc004ddj.2	+	1	189	c.130C>T	c.(130-132)CCG>TCG	p.P44S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	44										large_intestine(1)|lung(1)|ovary(1)	3						GCGGGTGATCCCGGCTGAGGT	0.562		NA											5	5					0	0	0	0
TAF1	6872	broad.mit.edu	37	X	70613166	70613166	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:70613166C>T	uc004dzu.3	+	21	3115	c.3064C>T	c.(3064-3066)CGC>TGC	p.R1022C	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.R1043C|TAF1_uc004dzv.3_Missense_Mutation_p.R196C	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1022					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AAAGTTGTCCCGCTGGGAAGT	0.323		NA											24	12					0	0	0	0
GPC3	2719	broad.mit.edu	37	X	132826430	132826430	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:132826430G>A	uc004exe.1	-	5	1449	c.1259C>T	c.(1258-1260)ACC>ATC	p.T420I	GPC3_uc004exd.1_Missense_Mutation_p.T292I|GPC3_uc010nrn.1_Missense_Mutation_p.T443I|GPC3_uc011mvh.1_Missense_Mutation_p.T404I|GPC3_uc010nro.1_Missense_Mutation_p.T366I|GPC3_uc010nrp.1_Missense_Mutation_p.T292I	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	420						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CCAGCAAAGGGTGTCGTTTTC	0.388		NA	T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				25	10					0	0	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994302	140994302	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chrX:140994302C>T	uc004fbt.2	+	4	1398	c.1112C>T	c.(1111-1113)TCT>TTT	p.S371F	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	371							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCCCAGTCTCCTCTCCAG	0.478		NA								HNSCC(15;0.026)			22	72					0	0	0	0
KIAA1409	57578	broad.mit.edu	37	14	94046720	94046721	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr14:94046720_94046721delGT	uc001ybv.1	+	16	2211_2212	c.2128_2129delGT	c.(2128-2130)GTGfs	p.V710fs	KIAA1409_uc001ybs.1_Frame_Shift_Del_p.V710fs	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	887						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAGCCGGCTGGTGGTAAGCAGT	0.441		NA											13	34	---	---	---	---	NA	NA	NA	NA
KCNH6	81033	broad.mit.edu	37	17	61601637	61601645	+	In_Frame_Del	DEL	CCCAACACA	CCCAACACA	-	rs143633824		TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr17:61601637_61601645delCCCAACACA	uc002jay.2	+	2	294_302	c.214_222delCCCAACACA	c.(214-222)CCCAACACAdel	p.PNT72del	KCNH6_uc002jax.1_In_Frame_Del_p.PNT72del|KCNH6_uc010wpl.1_Intron|KCNH6_uc010wpm.1_In_Frame_Del_p.PNT72del|KCNH6_uc002jaz.1_In_Frame_Del_p.PNT72del	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	72_74	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCTCACAGGCCCCAACACACCAAGCAGCG	0.612		NA											24	83	---	---	---	---	NA	NA	NA	NA
CILP2	148113	broad.mit.edu	37	19	19654650	19654659	+	Frame_Shift_Del	DEL	CGCCAGCTCC	CGCCAGCTCC	-			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr19:19654650_19654659delCGCCAGCTCC	uc002nmv.3	+	8	1381_1390	c.1296_1305delCGCCAGCTCC	c.(1294-1305)GACGCCAGCTCCfs	p.D432fs	CILP2_uc002nmw.3_Frame_Shift_Del_p.D438fs	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	432_435						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GCTGCGGGGACGCCAGCTCCCGCTGCTGCT	0.671		NA											32	59	---	---	---	---	NA	NA	NA	NA
TDRD7	23424	broad.mit.edu	37	9	100222899	100222899	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-6433-01A-11D-1683-08	TCGA-CV-6433-11A-01D-1683-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	16b220fa-a554-43c9-85b0-315331e5ba6e	90358019-128e-4a51-95de-13920ef19ab2	g.chr9:100222899delA	uc004axj.2	+	7	1520	c.1295delA	c.(1294-1296)CAAfs	p.Q432fs	TDRD7_uc011lux.1_Frame_Shift_Del_p.Q358fs	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	432	Lotus/OST-HTH 3.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				ATGGTTGAACAAGAGTATTTG	0.408		NA											27	91	---	---	---	---	NA	NA	NA	NA