Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PRAMEF10	343071	broad.mit.edu	37	1	12954474	12954474	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:12954474T>A	uc001auo.2	-	3	882	c.809A>T	c.(808-810)CAG>CTG	p.Q270L		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	270											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATAAAGCATCTGGGGGTAGTA	0.473		NA											41	165					0	0	0	0
CTRC	11330	broad.mit.edu	37	1	15771229	15771229	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:15771229G>A	uc001awi.1	+	6	645	c.622G>A	c.(622-624)GTC>ATC	p.V208I	CTRC_uc001awj.1_Intron	NM_007272	NP_009203	Q99895	CTRC_HUMAN	chymotrypsin C preproprotein	208	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCGATGGCGTCATCTCAGC	0.612		NA											9	55					0	0	0	0
SLC9A1	6548	broad.mit.edu	37	1	27427055	27427055	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:27427055C>T	uc001bnm.2	-	12	2817	c.2191G>A	c.(2191-2193)GAC>AAC	p.D731N	SLC9A1_uc001bnl.2_Missense_Mutation_p.D235N|SLC9A1_uc010ofk.1_Missense_Mutation_p.D392N	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	731	Cytoplasmic (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TTCACCAGGTCCACAGACTCG	0.602		NA											61	246					0	0	0	0
WASF2	10163	broad.mit.edu	37	1	27736225	27736225	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:27736225T>A	uc001bof.1	-	8	1516	c.1300A>T	c.(1300-1302)AGC>TGC	p.S434C	WASF2_uc010ofl.1_Intron	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	434					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		CGGGCATCGCTCACGGCAGGC	0.577		NA											12	72					0	0	0	0
PHACTR4	65979	broad.mit.edu	37	1	28800237	28800237	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:28800237C>G	uc001bpw.2	+	7	1277	c.995C>G	c.(994-996)TCG>TGG	p.S332W	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.S316W|PHACTR4_uc001bpy.2_Missense_Mutation_p.S342W	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	332	Pro-rich.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCTATGGGCTCGGAACTACTA	0.537		NA											35	122					0	0	0	0
AK2	204	broad.mit.edu	37	1	33502361	33502361	+	Silent	SNP	A	A	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:33502361A>G	uc001bwp.1	-	1	111	c.69T>C	c.(67-69)CCT>CCC	p.P23P	AK2_uc001bwo.1_Silent_p.P23P|AK2_uc010ohq.1_Silent_p.P23P|AK2_uc009vud.1_Silent_p.P23P|AK2_uc010ohr.1_5'UTR|AK2_uc001bwq.1_5'UTR	NM_001625	NP_001616	P54819	KAD2_HUMAN	adenylate kinase 2 isoform a	23	ATP (By similarity).				nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CGGCCCCGGGAGGCCCCAGCA	0.667		NA											2	10					0	0	0	0
ZMYM4	9202	broad.mit.edu	37	1	35853113	35853113	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:35853113A>T	uc001byt.2	+	13	2251	c.2171A>T	c.(2170-2172)AAT>ATT	p.N724I	ZMYM4_uc009vuu.2_Missense_Mutation_p.N692I|ZMYM4_uc001byu.2_Missense_Mutation_p.N400I|ZMYM4_uc009vuv.2_Missense_Mutation_p.N463I	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	724	MYM-type 7.				multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAATAAATAATGTAATGGCA	0.318		NA											12	34					0	0	0	0
CHI3L2	1117	broad.mit.edu	37	1	111778261	111778261	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:111778261G>T	uc001eam.2	+	6	552	c.481G>T	c.(481-483)GAG>TAG	p.E161*	CHI3L2_uc001ean.2_Nonsense_Mutation_p.E151*|CHI3L2_uc001eao.2_Nonsense_Mutation_p.E82*|CHI3L2_uc009wga.2_Nonsense_Mutation_p.E82*	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	161					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		TTTTTCCTAGGAGTTAGCAGA	0.448		NA											28	79					2.45e-14	2.95e-14	1	0
TADA1	117143	broad.mit.edu	37	1	166826916	166826916	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:166826916A>G	uc001gdw.2	-	8	1080	c.896T>C	c.(895-897)CTT>CCT	p.L299P	TADA1_uc001gdv.2_Missense_Mutation_p.L157P	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	299					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1						TTCAATGTTAAGAGCATAGAC	0.438		NA											26	63					0	0	0	0
LAMC1	3915	broad.mit.edu	37	1	183095288	183095288	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:183095288G>A	uc001gpy.3	+	16	3092	c.2835G>A	c.(2833-2835)GGG>GGA	p.G945G		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	945	Laminin EGF-like 10.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACCAATGGGCAGTGTGACA	0.507		NA											14	41					0	0	0	0
KCNT2	343450	broad.mit.edu	37	1	196197396	196197396	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:196197396G>T	uc001gtd.1	-	28	3426	c.3366C>A	c.(3364-3366)TGC>TGA	p.C1122*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.C1055*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.C1098*|KCNT2_uc001gtg.1_RNA	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1122	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CAGTGACATTGCAGATGCTGT	0.363		NA											5	23					0.000602214	0.000666649	1	0
CNTN2	6900	broad.mit.edu	37	1	205034950	205034950	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:205034950G>A	uc001hbr.2	+	14	1998	c.1729G>A	c.(1729-1731)GCC>ACC	p.A577T	CNTN2_uc001hbq.1_Missense_Mutation_p.A468T|CNTN2_uc001hbs.2_Missense_Mutation_p.A365T	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	577	Ig-like C2-type 6.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CATCCTGAACGCCCAGCTGCG	0.642		NA											15	53					0	0	0	0
ACBD3	64746	broad.mit.edu	37	1	226334387	226334387	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:226334387T>C	uc001hpy.2	-	8	1558	c.1511A>G	c.(1510-1512)TAT>TGT	p.Y504C		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	504	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		CTTGAGGAGATAGACTCCTCT	0.453		NA											18	81					0	0	0	0
OBSCN	84033	broad.mit.edu	37	1	228431117	228431117	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr1:228431117G>A	uc009xez.1	+	10	3207	c.3163G>A	c.(3163-3165)GAG>AAG	p.E1055K	OBSCN_uc001hsn.2_Missense_Mutation_p.E1055K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1055	Ig-like 10.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTACAGCTGCGAGGCCAGGGG	0.552		NA											8	35					0	0	0	0
FRMD4A	55691	broad.mit.edu	37	10	13698719	13698719	+	Missense_Mutation	SNP	G	G	A	rs143274194		TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:13698719G>A	uc001ims.2	-	22	3222	c.2870C>T	c.(2869-2871)TCG>TTG	p.S957L	FRMD4A_uc009xjf.1_Missense_Mutation_p.S957L	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	957	Ser-rich.					cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GCTGTACTGCGAGCCGCTGTC	0.667		NA											4	37					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	17126460	17126460	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:17126460G>A	uc001ioo.2	-	17	2163	c.2111C>T	c.(2110-2112)TCG>TTG	p.S704L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	704					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACGCAGATCCGCTAAGAACAG	0.502		NA											7	17					0	0	0	0
TFAM	7019	broad.mit.edu	37	10	60148561	60148561	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:60148561A>T	uc001jkf.2	+	4	555	c.423A>T	c.(421-423)AAA>AAT	p.K141N	TFAM_uc001jkg.2_RNA|TFAM_uc001jkh.2_Missense_Mutation_p.K141N	NM_003201	NP_003192	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial precursor	141					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TAAAAAGGAAAGCTATGACAA	0.264		NA											19	69					0	0	0	0
DUPD1	338599	broad.mit.edu	37	10	76803647	76803647	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:76803647C>G	uc001jwq.1	-	2	329	c.329G>C	c.(328-330)GGC>GCC	p.G110A		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	110	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GGCCTCCACGCCGTGGTACTG	0.637		NA											21	69					0	0	0	0
RRP12	23223	broad.mit.edu	37	10	99132919	99132919	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:99132919A>C	uc001knf.2	-	18	2204	c.2065T>G	c.(2065-2067)TTT>GTT	p.F689V	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Missense_Mutation_p.F407V|RRP12_uc010qou.1_Missense_Mutation_p.F628V|RRP12_uc009xvn.2_Missense_Mutation_p.F589V	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	689						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		ATCGGCAGAAAGTTCTTGGCA	0.567		NA											4	74					0	0	0	0
SORCS3	22986	broad.mit.edu	37	10	106960976	106960976	+	Silent	SNP	A	A	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr10:106960976A>C	uc001kyi.1	+	16	2453	c.2226A>C	c.(2224-2226)TCA>TCC	p.S742S	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	742	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGTGGTCTCAGAACCCTGTG	0.522		NA											15	85					0	0	0	0
SWAP70	23075	broad.mit.edu	37	11	9759763	9759763	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:9759763C>T	uc001mhw.2	+	8	1183	c.1084C>T	c.(1084-1086)CTG>TTG	p.L362L	SWAP70_uc001mhv.2_Silent_p.L362L|SWAP70_uc001mhx.2_Silent_p.L304L	NM_015055	NP_055870	Q9UH65	SWP70_HUMAN	SWAP-70 protein	362	Potential.					cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			ovary(2)|central_nervous_system(1)	3				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		TGGCTAGAAACTGGAGGAAGC	0.448		NA											11	29					0	0	0	0
ZDHHC5	25921	broad.mit.edu	37	11	57466839	57466839	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:57466839C>T	uc001nkx.1	+	11	3187	c.1931C>T	c.(1930-1932)CCT>CTT	p.P644L	ZDHHC5_uc001nky.1_Missense_Mutation_p.P591L|ZDHHC5_uc001nkz.1_Missense_Mutation_p.P458L	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	644						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						AAAGCCCAACCTGGTGTCTCT	0.527		NA											22	66					0	0	0	0
NUDT22	84304	broad.mit.edu	37	11	63994371	63994371	+	Missense_Mutation	SNP	G	G	T	rs143695088	by1000genomes	TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:63994371G>T	uc001nyp.3	+	2	427	c.247G>T	c.(247-249)GGC>TGC	p.G83C	TRPT1_uc010rnc.1_5'Flank|TRPT1_uc010rnd.1_5'Flank|TRPT1_uc001nyn.2_5'Flank|TRPT1_uc001nyo.2_5'Flank|TRPT1_uc010rne.1_5'Flank|TRPT1_uc010rnf.1_5'Flank|NUDT22_uc009ypd.2_Missense_Mutation_p.G83C|NUDT22_uc009ype.2_Missense_Mutation_p.G83C|NUDT22_uc001nyq.3_Missense_Mutation_p.G83C|NUDT22_uc010rng.1_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety	83							hydrolase activity				0						CCTGCGCCTGGGCCTTACTTC	0.662		NA											20	75					1.64e-05	1.87e-05	1	0
ACTN3	89	broad.mit.edu	37	11	66330375	66330375	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:66330375G>C	uc001oio.1	+	21	2515	c.2497G>C	c.(2497-2499)GAC>CAC	p.D833H	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	833					focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						AGCCGAGACTGACACGACTGA	0.597		NA											5	161					0	0	0	0
LRFN4	78999	broad.mit.edu	37	11	66626406	66626406	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:66626406C>T	uc001ojr.2	+	1	1531	c.1191C>T	c.(1189-1191)GCC>GCT	p.A397A	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Silent_p.A397A	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	397	Extracellular (Potential).					integral to membrane					0						GCACTGCTGCCGAGGGTGAGG	0.731		NA											5	57					0	0	0	0
XRRA1	143570	broad.mit.edu	37	11	74562186	74562186	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:74562186T>G	uc009yub.2	-	14	1635	c.1303A>C	c.(1303-1305)AAG>CAG	p.K435Q	XRRA1_uc001ovm.2_RNA|XRRA1_uc001ovn.2_Missense_Mutation_p.K58Q|XRRA1_uc001ovo.2_Missense_Mutation_p.K43Q|XRRA1_uc001ovq.3_Missense_Mutation_p.K348Q|XRRA1_uc001ovp.3_Missense_Mutation_p.K160Q|XRRA1_uc001ovr.2_Missense_Mutation_p.K58Q|XRRA1_uc001ovs.1_Intron	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	435					response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						TTTACTATCTTCCTTCGAATT	0.488		NA											10	35					0	0	0	0
PICALM	8301	broad.mit.edu	37	11	85712203	85712203	+	Splice_Site	SNP	T	T	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:85712203T>A	uc001pbm.2	-	10	1180	c.894_splice	c.e10-1	p.R298_splice	PICALM_uc001pbl.2_Splice_Site_p.R298_splice|PICALM_uc001pbn.2_Splice_Site_p.R298_splice|PICALM_uc010rtl.1_Splice_Site_p.R247_splice|PICALM_uc010rtk.1_Splice_Site|PICALM_uc001pbo.1_Splice_Site	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly						clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				GTAGTTGCCCTAGGATAATTG	0.443		NA	T	MLLT10|MLL	TALL|AML|								21	75					0	0	0	0
PRSS23	11098	broad.mit.edu	37	11	86518800	86518800	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:86518800G>A	uc001pcb.2	+	2	331	c.115G>A	c.(115-117)GTC>ATC	p.V39I	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Missense_Mutation_p.V39I	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	39					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCGCCTCCCTGTCGTCTTGCC	0.537		NA											22	87					0	0	0	0
MMP3	4314	broad.mit.edu	37	11	102709884	102709884	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:102709884G>A	uc001phj.1	-	7	1091	c.1026C>T	c.(1024-1026)GCC>GCT	p.A342A		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	342	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.A342A(1)		lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CTTCATATGCGGCATCCACGC	0.378		NA											21	59					0	0	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103022985	103022985	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:103022985G>T	uc001pho.2	+	21	3211	c.3067G>T	c.(3067-3069)GAA>TAA	p.E1023*	DYNC2H1_uc001phn.1_Nonsense_Mutation_p.E1023*|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1023	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GTTAATGATGGAAAGTCACCA	0.303		NA											6	45					0.00198382	0.0021693	1	0
NPAT	4863	broad.mit.edu	37	11	108044157	108044157	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:108044157T>A	uc001pjz.3	-	13	1656	c.1554A>T	c.(1552-1554)GAA>GAT	p.E518D	NPAT_uc001pka.2_Missense_Mutation_p.E313D	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	518					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		CATTGTTAGCTTCACAACCAA	0.348		NA											19	51					0	0	0	0
VWA5A	4013	broad.mit.edu	37	11	123993667	123993667	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr11:123993667G>A	uc001pzu.2	+	8	970	c.761G>A	c.(760-762)GGT>GAT	p.G254D	VWA5A_uc001pzr.2_Missense_Mutation_p.G254D|VWA5A_uc001pzs.2_Missense_Mutation_p.G254D|VWA5A_uc010sae.1_Missense_Mutation_p.G270D|VWA5A_uc001pzt.2_Missense_Mutation_p.G254D	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	254										upper_aerodigestive_tract(1)|ovary(1)	2						TTCTGAACAGGTCATTTGATG	0.383		NA											4	38					0	0	0	0
TMTC1	83857	broad.mit.edu	37	12	29659813	29659813	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:29659813C>T	uc001rjb.2	-	18	2765	c.2291G>A	c.(2290-2292)CGA>CAA	p.R764Q	TMTC1_uc001riz.2_Missense_Mutation_p.R521Q|TMTC1_uc001rja.2_Missense_Mutation_p.R608Q|TMTC1_uc001riy.2_Missense_Mutation_p.R217Q	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	872						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TTCTTGTAATCGTTTTTCTAG	0.448		NA											15	143					0	0	0	0
SILV	6490	broad.mit.edu	37	12	56351770	56351771	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:56351770_56351771GG>AA	uc001sip.2	-	5	598_599	c.567_568CC>TT	c.(565-570)TACCAT>TATTAT	p.H190Y	SILV_uc001siq.2_Missense_Mutation_p.H190Y|SILV_uc010spx.1_Missense_Mutation_p.H104Y|SILV_uc001sir.2_Missense_Mutation_p.H190Y	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	190					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						CCCCGGCGATGGTAGACAGTCA	0.579		NA											13	71					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	72863583	72863583	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:72863583G>T	uc001sxa.2	+	4	1256	c.1226G>T	c.(1225-1227)TGG>TTG	p.W409L		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	409	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						ATGGAGAACTGGGGACTAAGT	0.378		NA											15	67					4.75e-09	5.56e-09	1	0
DNAH10	196385	broad.mit.edu	37	12	124268652	124268652	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:124268652C>T	uc001uft.3	+	8	1000	c.975C>T	c.(973-975)ACC>ACT	p.T325T		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	325	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGTGTTCACCGAGTTATTCA	0.488		NA											17	62					0	0	0	0
EP400	57634	broad.mit.edu	37	12	132534871	132534871	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr12:132534871A>G	uc001ujn.2	+	39	7239	c.7204A>G	c.(7204-7206)AAA>GAA	p.K2402E	EP400_uc001ujl.2_Missense_Mutation_p.K2401E|EP400_uc001ujm.2_Missense_Mutation_p.K2321E	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2438					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ATTGCAGAGTAAAAACAACCG	0.507		NA											16	71					0	0	0	0
TGDS	23483	broad.mit.edu	37	13	95230316	95230316	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr13:95230316G>T	uc001vlw.2	-	9	889	c.768C>A	c.(766-768)AAC>AAA	p.N256K	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	256					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					TGGTTCCGATGTTATAAATTT	0.358		NA											7	34					0.00198382	0.0021693	1	0
FAM158A	51016	broad.mit.edu	37	14	24610485	24610485	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr14:24610485G>C	uc001wmi.2	-	2	192	c.29C>G	c.(28-30)GCC>GGC	p.A10G		NM_016049	NP_057133	Q9Y3B6	F158A_HUMAN	hypothetical protein LOC51016	10				ALA -> GPG (in Ref. 1; AAD34107).							0						CTTCACGTAGGCCAGGGCCGA	0.657		NA									OREG0022618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	68					0	0	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409742	105409742	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr14:105409742G>T	uc010axc.1	-	7	12166	c.12046C>A	c.(12046-12048)CTC>ATC	p.L4016I	AHNAK2_uc001ypx.2_Missense_Mutation_p.L3916I	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4016						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGAACGCTGAGGTCAGTGGCC	0.657		NA											113	238					3.68e-61	4.46e-61	1	0
OR4M2	390538	broad.mit.edu	37	15	22369305	22369305	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr15:22369305T>G	uc010tzu.1	+	1	730	c.730T>G	c.(730-732)TCC>GCC	p.S244A	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CACCTGCTATTCCCACATTAC	0.448		NA											19	136					0	0	0	0
ZWILCH	55055	broad.mit.edu	37	15	66828269	66828269	+	Splice_Site	SNP	A	A	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr15:66828269A>T	uc002aqb.2	+	15	1588	c.1342_splice	c.e15-2	p.E448_splice	ZWILCH_uc010bhu.1_Splice_Site_p.E334_splice|ZWILCH_uc002aqa.2_Splice_Site_p.E334_splice|ZWILCH_uc010bhv.2_Splice_Site_p.E334_splice	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch						cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						TTTTCATTCCAGGAATACTTC	0.343		NA											4	50					0	0	0	0
MAP2K5	5607	broad.mit.edu	37	15	67995696	67995696	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr15:67995696C>A	uc002aqu.2	+	16	1647	c.994C>A	c.(994-996)CAG>AAG	p.Q332K	MAP2K5_uc002aqv.2_Missense_Mutation_p.Q332K|MAP2K5_uc002aqw.2_Missense_Mutation_p.Q172K|MAP2K5_uc002aqx.2_Missense_Mutation_p.Q142K	NM_145160	NP_660143	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	332	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)	2						TTCAGGGGAGCAGTATGGAAT	0.423		NA											22	91					1.11e-09	1.3e-09	1	0
CACNA1H	8912	broad.mit.edu	37	16	1260937	1260937	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr16:1260937G>A	uc002cks.2	+	21	4437	c.4189G>A	c.(4189-4191)GTG>ATG	p.V1397M	CACNA1H_uc002ckt.2_Missense_Mutation_p.V1397M|CACNA1H_uc002cku.2_Missense_Mutation_p.V103M|CACNA1H_uc010brj.2_Missense_Mutation_p.V103M|CACNA1H_uc002ckv.2_Missense_Mutation_p.V103M	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1397	III.|Helical; Name=S4 of repeat III; (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TGTTCTGCGCGTGCTGCGTCT	0.682		NA											39	141					0	0	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29884953	29884953	+	Silent	SNP	C	C	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr16:29884953C>A	uc002duq.3	-	13	2442	c.2202G>T	c.(2200-2202)CTG>CTT	p.L734L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.L664L|SEZ6L2_uc002dur.3_Silent_p.L664L|SEZ6L2_uc002dus.3_Silent_p.L620L|SEZ6L2_uc010vec.1_Silent_p.L734L|SEZ6L2_uc010ved.1_Silent_p.L690L	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	734	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TGTACCCTGGCAGGCAGCGGT	0.657		NA											6	45					0.00116845	0.00128816	1	0
TP53	7157	broad.mit.edu	37	17	7578235	7578235	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:7578235T>C	uc002gim.2	-	6	808	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	TP53_uc002gig.1_Missense_Mutation_p.Y205C|TP53_uc002gih.2_Missense_Mutation_p.Y205C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y73C|TP53_uc010cng.1_Missense_Mutation_p.Y73C|TP53_uc002gii.1_Missense_Mutation_p.Y73C|TP53_uc010cnh.1_Missense_Mutation_p.Y205C|TP53_uc010cni.1_Missense_Mutation_p.Y205C|TP53_uc002gij.2_Missense_Mutation_p.Y205C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y112C|TP53_uc002gio.2_Missense_Mutation_p.Y73C|TP53_uc010vug.1_Missense_Mutation_p.Y166C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*42(1)|p.Y112C(1)|p.Y205fs*43(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATCCAAATACTCCACACG	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	26					0	0	0	0
MBTD1	54799	broad.mit.edu	37	17	49270365	49270365	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:49270365G>C	uc002itr.3	-	15	1812	c.1468C>G	c.(1468-1470)CAC>GAC	p.H490D	MBTD1_uc002itp.3_Missense_Mutation_p.H326D|MBTD1_uc002itq.3_3'UTR	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	490	MBT 4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			CGAAATCCGTGATTTGGAACA	0.378		NA											20	99					0	0	0	0
ANKFN1	162282	broad.mit.edu	37	17	54428211	54428211	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:54428211C>T	uc002iun.1	+	4	317	c.282C>T	c.(280-282)AAC>AAT	p.N94N		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	94										large_intestine(1)|ovary(1)	2						CATCTCCCAACGCAGCCAAAC	0.448		NA											9	45					0	0	0	0
ABCA5	23461	broad.mit.edu	37	17	67270205	67270205	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:67270205T>C	uc002jif.2	-	19	3877	c.2659A>G	c.(2659-2661)AAA>GAA	p.K887E	ABCA5_uc002jic.2_Missense_Mutation_p.K110E|ABCA5_uc002jid.2_5'UTR|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.K887E|ABCA5_uc002jih.2_Missense_Mutation_p.K887E|ABCA5_uc010dfe.2_Missense_Mutation_p.K887E	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	887					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					ACAGCATTTTTAAAAGAGTGA	0.323		NA											13	48					0	0	0	0
KCTD2	23510	broad.mit.edu	37	17	73059132	73059132	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:73059132C>T	uc002jmp.2	+	6	849	c.782C>T	c.(781-783)TCG>TTG	p.S261L	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	261						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					GAGAGAGGATCGCGGATGTAA	0.552		NA											4	21					0	0	0	0
CASKIN2	57513	broad.mit.edu	37	17	73500710	73500710	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr17:73500710C>T	uc002joc.2	-	12	1807	c.1257G>A	c.(1255-1257)GGG>GGA	p.G419G	CASKIN2_uc010wsc.1_Silent_p.G337G	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	419						cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGAGCTCTGCCCGCTGCCGG	0.642		NA											3	22					0	0	0	0
MC2R	4158	broad.mit.edu	37	18	13885391	13885391	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr18:13885391G>A	uc002ksp.1	-	2	304	c.127C>T	c.(127-129)CTG>TTG	p.L43L		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	43	Helical; Name=1; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	AGGACGATCAGATTCTCCAAA	0.428		NA											11	30					0	0	0	0
YIPF2	78992	broad.mit.edu	37	19	11038315	11038315	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:11038315G>A	uc002mqb.2	-	4	394	c.270C>T	c.(268-270)GAC>GAT	p.D90D	YIPF2_uc002mqc.2_Silent_p.D90D|C19orf52_uc002mqd.1_5'Flank	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	90	Cytoplasmic (Potential).					integral to membrane|transport vesicle					0						CCTGTGAGGTGTCCACGTCAA	0.512		NA											7	40					0	0	0	0
ZNF284	342909	broad.mit.edu	37	19	44590486	44590486	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:44590486G>A	uc002oyg.1	+	5	1071	c.855G>A	c.(853-855)AAG>AAA	p.K285K	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				CTGGGGAGAAGCCATTCAAAT	0.393		NA											23	72					0	0	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986513	51986513	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:51986513A>T	uc002pwv.1	+	5	1099	c.1099A>T	c.(1099-1101)ATC>TTC	p.I367F		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	367	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GACACAGCTGATCATGTACAT	0.582		NA											22	57					0	0	0	0
LENG8	114823	broad.mit.edu	37	19	54965698	54965698	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:54965698C>T	uc002qfv.1	+	5	549	c.405C>T	c.(403-405)CCC>CCT	p.P135P	LENG8_uc002qfw.2_Silent_p.P172P			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	135							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CCTCAAATCCCCCACATGGGG	0.687		NA											4	24					0	0	0	0
ZNF628	89887	broad.mit.edu	37	19	55995170	55995170	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:55995170G>A	uc002qld.2	+	3	3163	c.2598G>A	c.(2596-2598)GTG>GTA	p.V866V	NAT14_uc002qle.1_5'Flank	NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	866						nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		TCCAGCCCGTGGCCGGCCAGC	0.647		NA											6	42					0	0	0	0
ZNF154	7710	broad.mit.edu	37	19	58213526	58213526	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr19:58213526C>T	uc010euf.2	-	3	1031	c.791G>A	c.(790-792)CGG>CAG	p.R264Q	ZNF776_uc002qpx.2_Intron|ZNF154_uc002qpy.2_RNA	NM_001085384	NP_001078853	Q13106	ZN154_HUMAN	zinc finger protein 154	264	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGAACTCCCCGATGTTGAAG	0.453		NA											23	90					0	0	0	0
ZNF512	84450	broad.mit.edu	37	2	27822849	27822849	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:27822849G>A	uc002rla.2	+	5	473	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	ZNF512_uc010ylv.1_Missense_Mutation_p.R50Q|ZNF512_uc010ylw.1_Intron|ZNF512_uc002rlb.2_Missense_Mutation_p.R50Q|ZNF512_uc010ylx.1_Missense_Mutation_p.R50Q|ZNF512_uc002rlc.2_Missense_Mutation_p.R50Q|ZNF512_uc010yly.1_RNA|ZNF512_uc010ylz.1_Intron	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGGAAGCAACGGCCTAAAACT	0.473		NA											6	18					0	0	0	0
NEB	4703	broad.mit.edu	37	2	152375496	152375496	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:152375496T>G	uc010fnx.2	-	127	17766	c.17575A>C	c.(17575-17577)AGC>CGC	p.S5859R	NEB_uc002txr.2_Missense_Mutation_p.S2282R|NEB_uc002txt.3_Missense_Mutation_p.S364R	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5859	Nebulin 160.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCAAGTTGGCTTGTATTCAGG	0.423		NA											5	32					0	0	0	0
XIRP2	129446	broad.mit.edu	37	2	168106357	168106357	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:168106357G>A	uc002udx.2	+	8	8473	c.8455G>A	c.(8455-8457)GAA>AAA	p.E2819K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2644K|XIRP2_uc010fpq.2_Missense_Mutation_p.E2597K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.E165K	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2644					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCCAGGAAGTGAAGAAAAAAA	0.393		NA											8	32					0	0	0	0
TLK1	9874	broad.mit.edu	37	2	171906348	171906348	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:171906348C>G	uc002ugn.2	-	10	1428	c.956G>C	c.(955-957)GGT>GCT	p.G319A	TLK1_uc002ugo.2_Missense_Mutation_p.G340A|TLK1_uc002ugp.2_Missense_Mutation_p.G271A|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Missense_Mutation_p.G223A|TLK1_uc002ugr.1_Missense_Mutation_p.G102A	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	319					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						AAATGCAAAACCATCTGTCCA	0.348		NA											12	49					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179483053	179483053	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:179483053G>T	uc010zfg.1	-	201	39652	c.39428C>A	c.(39427-39429)GCA>GAA	p.A13143E	TTN_uc010zfh.1_Missense_Mutation_p.A6838E|TTN_uc010zfi.1_Missense_Mutation_p.A6771E|TTN_uc010zfj.1_Missense_Mutation_p.A6646E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14070							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACTCTCTGCACGGTCTGT	0.463		NA											15	87					6.32e-08	7.36e-08	1	0
TTN	7273	broad.mit.edu	37	2	179549086	179549086	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr2:179549086G>A	uc010zfg.1	-	129	29185	c.28961C>T	c.(28960-28962)ACT>ATT	p.T9654I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T6315I|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10581							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTTTTTTAGTTACAGCAAC	0.398		NA											4	36					0	0	0	0
SIRPB1	10326	broad.mit.edu	37	20	1600540	1600540	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr20:1600540C>A	uc010gai.2	-	1	150	c.51G>T	c.(49-51)ATG>ATT	p.M17I	SIRPB1_uc002wfk.3_Missense_Mutation_p.M17I|SIRPB1_uc002wfl.3_Missense_Mutation_p.M17I	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	17					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						GCAGTAGCGTCATCAGCAGGA	0.562		NA											7	62					1.13e-05	1.3e-05	1	0
SEL1L2	80343	broad.mit.edu	37	20	13856702	13856702	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr20:13856702A>T	uc010gcf.2	-	12	1168	c.1086T>A	c.(1084-1086)TTT>TTA	p.F362L	SEL1L2_uc002woq.3_Missense_Mutation_p.F223L|SEL1L2_uc010zrl.1_Missense_Mutation_p.F362L|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	362	Extracellular (Potential).|Sel1-like 6.					integral to membrane	binding			ovary(2)	2						CTGCCATGGAAAAGTACTTGA	0.393		NA											42	110					0	0	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20127696	20127696	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:20127696T>A	uc002zrq.2	+	5	722	c.616T>A	c.(616-618)TTC>ATC	p.F206I	ZDHHC8_uc002zrr.1_Missense_Mutation_p.F206I|ZDHHC8_uc010gsa.2_Intron	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	206	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					CCTCACTGGCTTCCATGTGGT	0.637		NA											6	32					0	0	0	0
MORC2	22880	broad.mit.edu	37	22	31333632	31333632	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:31333632G>A	uc003aje.1	-	16	2614	c.1250C>T	c.(1249-1251)CCG>CTG	p.P417L		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	479							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						CTCACTGGATGGGGGCTGGTT	0.547		NA											10	58					0	0	0	0
NUP50	10762	broad.mit.edu	37	22	45574201	45574201	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:45574201C>T	uc003bfr.2	+	5	885	c.423C>T	c.(421-423)TCC>TCT	p.S141S	NUP50_uc003bfs.2_Silent_p.S113S|NUP50_uc011aqn.1_5'UTR|NUP50_uc003bft.2_Silent_p.S113S|NUP50_uc011aqo.1_5'UTR	NM_007172	NP_009103	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa isoform b	141	5 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		AGCAGCCCTCCTCCTCTGGCC	0.483		NA											10	40					0	0	0	0
SOX2	6657	broad.mit.edu	37	3	181430873	181430873	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr3:181430873C>T	uc003fkx.2	+	1	1152	c.725C>T	c.(724-726)TCG>TTG	p.S242L	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	242					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			TCCATGGGTTCGGTGGTCAAG	0.652		NA	A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						16	95					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597		NA											4	4					0	0	0	0
ABCG2	9429	broad.mit.edu	37	4	89052340	89052340	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr4:89052340G>T	uc003hrg.2	-	5	897	c.404C>A	c.(403-405)ACG>AAG	p.T135K	ABCG2_uc003hrh.2_Missense_Mutation_p.T135K|ABCG2_uc003hrf.2_Missense_Mutation_p.T5K	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	135	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TTCTCTCACCGTCAGAGTGCC	0.378		NA											10	88					0.00621372	0.00668596	1	0
METTL14	57721	broad.mit.edu	37	4	119621732	119621732	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr4:119621732G>C	uc003icf.2	+	8	789	c.673G>C	c.(673-675)GCA>CCA	p.A225P	METTL14_uc003icg.2_Missense_Mutation_p.A187P	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	225						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						TGATGAGATTGCAGCACCTCG	0.348		NA											8	51					0	0	0	0
SEC24D	9871	broad.mit.edu	37	4	119727067	119727067	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr4:119727067C>G	uc003ici.3	-	7	1116	c.844G>C	c.(844-846)GTT>CTT	p.V282L	SEC24D_uc003icj.3_Missense_Mutation_p.V283L|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	282	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						GTGGCATAAACTTGTCCTCCT	0.428		NA											19	52					0	0	0	0
CTNND2	1501	broad.mit.edu	37	5	11082866	11082866	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr5:11082866G>A	uc003jfa.1	-	16	2875	c.2730C>T	c.(2728-2730)TGC>TGT	p.C910C	CTNND2_uc010itt.2_Silent_p.C819C|CTNND2_uc011cmy.1_Silent_p.C573C|CTNND2_uc011cmz.1_Silent_p.C477C|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.C502C	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	910	ARM 8.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGGCCACCGCGCACACCACAC	0.527		NA											20	77					0	0	0	0
CRHBP	1393	broad.mit.edu	37	5	76251503	76251503	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr5:76251503G>A	uc003ker.2	+	4	639	c.359G>A	c.(358-360)GGG>GAG	p.G120E	CRHBP_uc010izx.2_Missense_Mutation_p.G120E	NM_001882	NP_001873	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	120					female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		ATTCTCAAGGGGGAGAAGTTC	0.458		NA											14	52					0	0	0	0
HMMR	3161	broad.mit.edu	37	5	162900509	162900509	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr5:162900509T>G	uc003lzf.2	+	9	1029	c.847T>G	c.(847-849)TCT>GCT	p.S283A	HMMR_uc003lzh.2_Missense_Mutation_p.S284A|HMMR_uc003lzg.2_Missense_Mutation_p.S268A|HMMR_uc011dem.1_Missense_Mutation_p.S197A	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	283						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		TGTTATATTATCTAAACAAGT	0.289		NA											5	45					0	0	0	0
PRL	5617	broad.mit.edu	37	6	22290542	22290542	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:22290542G>T	uc003ndp.2	-	4	872	c.353C>A	c.(352-354)TCC>TAC	p.S118Y	PRL_uc003ndo.2_Missense_Mutation_p.S119Y|PRL_uc003ndq.2_Missense_Mutation_p.S118Y	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	118				S -> P (in Ref. 6; AAB70858).	cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					CTCATTCCAGGATCGCAATAT	0.428		NA											4	48					0.000602214	0.000666649	1	0
HIST1H3F	8968	broad.mit.edu	37	6	26250638	26250638	+	Silent	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:26250638G>A	uc003nhg.1	-	1	198	c.196C>T	c.(196-198)CTA>TTA	p.L66L	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	66					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						TGGAATGGTAGCTTGCGAATC	0.612		NA									OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	117					0	0	0	0
ZNF192	7745	broad.mit.edu	37	6	28116421	28116421	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:28116421G>T	uc003nkn.1	+	2	420	c.236G>T	c.(235-237)TGG>TTG	p.W79L	ZNF192_uc010jqx.1_Missense_Mutation_p.W79L|ZNF192_uc010jqy.1_5'UTR|ZNF192_uc011dkz.1_5'UTR	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	79	SCAN box.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGCCATCAGTGGCTGAGGCCA	0.562		NA											13	65					4.38e-07	5.08e-07	1	0
MAS1L	116511	broad.mit.edu	37	6	29455526	29455526	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:29455526G>A	uc011dlq.1	-	1	154	c.154C>T	c.(154-156)CTT>TTT	p.L52F		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	52	Extracellular (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						TCATTTTGAAGAAAGACGCCA	0.507		NA											20	56					0	0	0	0
TNXB	7148	broad.mit.edu	37	6	32020730	32020730	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:32020730C>T	uc003nzl.2	-	26	9028	c.8826G>A	c.(8824-8826)ACG>ACA	p.T2942T		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2989					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCGGGGCCTCCGTGCTGGGTT	0.657		NA											14	100					0	0	0	0
HLA-DMB	3109	broad.mit.edu	37	6	32906579	32906579	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:32906579C>T	uc003ocl.1	-	2	452	c.219G>A	c.(217-219)GCG>GCA	p.A73A	HLA-DMB_uc003ocj.1_Silent_p.A73A|HLA-DMB_uc003ock.1_5'Flank|HLA-DMB_uc010jud.1_5'Flank|HLA-DMB_uc010jue.1_5'Flank|HLA-DMB_uc010juf.1_5'Flank|HLA-DMB_uc011dql.1_Silent_p.A73A	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	73	Beta-1.|Lumenal (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						AGAGGACATTCGCCAAGCTAT	0.527		NA											17	96					0	0	0	0
ENPP4	22875	broad.mit.edu	37	6	46107985	46107985	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:46107985A>G	uc003oxy.2	+	2	924	c.665A>G	c.(664-666)AAG>AGG	p.K222R		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	222	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						CAAAGACTCAAGATGTTAGGG	0.408		NA											17	68					0	0	0	0
RIPPLY2	134701	broad.mit.edu	37	6	84563844	84563844	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:84563844C>T	uc003pke.2	+	3	354	c.203C>T	c.(202-204)GCC>GTC	p.A68V		NM_001009994	NP_001009994	Q5TAB7	RIPP2_HUMAN	ripply2 protein	68					somite rostral/caudal axis specification	nucleus					0						ATGACCGCAGCCTCAGGAAAG	0.587		NA											10	56					0	0	0	0
ARID1B	57492	broad.mit.edu	37	6	157525122	157525122	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:157525122C>G	uc003qqn.2	+	19	5115	c.4963C>G	c.(4963-4965)CTC>GTC	p.L1655V	ARID1B_uc003qqo.2_Missense_Mutation_p.L1615V|ARID1B_uc003qqp.2_Missense_Mutation_p.L1602V	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1660					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TACTTTCAATCTCTCCCAGGT	0.428		NA											75	258					0	0	0	0
MLLT4	4301	broad.mit.edu	37	6	168281147	168281147	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:168281147G>C	uc003qwd.2	+	6	986	c.844G>C	c.(844-846)GAG>CAG	p.E282Q	MLLT4_uc003qwb.1_Missense_Mutation_p.E282Q|MLLT4_uc003qwc.1_Missense_Mutation_p.E283Q|MLLT4_uc003qwf.2_5'UTR	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	283	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGAAGCTTTAGAGAAGTATGG	0.383		NA	T	MLL	AL								16	157					0	0	0	0
RBAK	57786	broad.mit.edu	37	7	5103363	5103363	+	Silent	SNP	A	A	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:5103363A>G	uc010kss.1	+	6	600	c.276A>G	c.(274-276)CAA>CAG	p.Q92Q	LOC389458_uc003snr.2_Silent_p.Q92Q|RBAK_uc003sns.1_Silent_p.Q92Q	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	92					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AGAGAATCCAAGAAAACGAAG	0.353		NA											4	20					0	0	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762824	92762824	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:92762824C>T	uc003umh.1	-	5	3677	c.2461G>A	c.(2461-2463)GTT>ATT	p.V821I	SAMD9L_uc003umj.1_Missense_Mutation_p.V821I|SAMD9L_uc003umi.1_Missense_Mutation_p.V821I|SAMD9L_uc010lfb.1_Missense_Mutation_p.V821I|SAMD9L_uc003umk.1_Missense_Mutation_p.V821I|SAMD9L_uc010lfc.1_Missense_Mutation_p.V821I|SAMD9L_uc010lfd.1_Missense_Mutation_p.V821I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	821										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCTGCTAAAACGGAATGGATG	0.383		NA											20	52					0	0	0	0
LMTK2	22853	broad.mit.edu	37	7	97821898	97821898	+	Silent	SNP	C	C	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:97821898C>T	uc003upd.1	+	11	2414	c.2121C>T	c.(2119-2121)CAC>CAT	p.H707H		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	707					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					ATCTTATGCACCAAGATAATT	0.363		NA											14	75					0	0	0	0
LRGUK	136332	broad.mit.edu	37	7	133886291	133886291	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr7:133886291G>C	uc003vrm.1	+	15	1822	c.1806G>C	c.(1804-1806)TTG>TTC	p.L602F		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	602							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						ACCTTGGATTGACTGAGGAAC	0.388		NA											7	48					0	0	0	0
ERI1	90459	broad.mit.edu	37	8	8869134	8869134	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:8869134G>T	uc011kwu.1	+	3	630	c.370G>T	c.(370-372)GAC>TAC	p.D124Y	ERI1_uc003wsk.2_Missense_Mutation_p.D124Y	NM_153332	NP_699163	Q8IV48	ERI1_HUMAN	three prime histone mRNA exonuclease 1	124					gene silencing by RNA|rRNA 3'-end processing	cytoplasm|histone pre-mRNA 3'end processing complex|nucleolus	3'-5' exonuclease activity|histone pre-mRNA stem-loop binding|metal ion binding|ribosome binding|rRNA binding				0					Adenosine monophosphate(DB00131)	CAATTTTGCTGACAGTTATTA	0.348		NA											17	30					1.03e-11	1.22e-11	1	0
ZFHX4	79776	broad.mit.edu	37	8	77763207	77763207	+	Silent	SNP	G	G	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:77763207G>C	uc003yav.2	+	10	4302	c.3915G>C	c.(3913-3915)CCG>CCC	p.P1305P	ZFHX4_uc003yau.1_Silent_p.P1350P|ZFHX4_uc003yaw.1_Silent_p.P1305P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1305						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCAGAAACCGACTAAAGAAC	0.398		NA								HNSCC(33;0.089)			8	32					0	0	0	0
NBN	4683	broad.mit.edu	37	8	90949281	90949281	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:90949281T>C	uc003yej.1	-	15	2317	c.2207A>G	c.(2206-2208)GAA>GGA	p.E736G	NBN_uc003yei.1_Missense_Mutation_p.E654G|NBN_uc011lgb.1_Missense_Mutation_p.K729E	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	736	EEXXXDDL motif.			EE->AA: Decreases ATM binding.	cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AAGAGACTCTTCTTTTGCATG	0.299		NA						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				6	30					0	0	0	0
INTS8	55656	broad.mit.edu	37	8	95839504	95839504	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:95839504G>A	uc003yhb.2	+	3	445	c.319G>A	c.(319-321)GTA>ATA	p.V107I	INTS8_uc003yha.1_Missense_Mutation_p.V107I|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_5'Flank	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	107					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					GTCTGTTCCAGTATTGAATAT	0.383		NA											35	60					0	0	0	0
TG	7038	broad.mit.edu	37	8	133925427	133925427	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:133925427C>A	uc003ytw.2	+	20	4336	c.4295C>A	c.(4294-4296)ACC>AAC	p.T1432N	TG_uc010mdw.2_Missense_Mutation_p.T191N	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1432					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACTTTGGCACCTCTCCCAGG	0.557		NA											15	57					2.23e-06	2.58e-06	1	0
TMEM2	23670	broad.mit.edu	37	9	74364981	74364981	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr9:74364981T>C	uc011lsa.1	-	2	849	c.309A>G	c.(307-309)ATA>ATG	p.I103M	TMEM2_uc010mos.2_Missense_Mutation_p.I103M|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	103	Helical; (Potential).					integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ATTTTGAGGATATTCCTAAAA	0.294		NA											6	29					0	0	0	0
SVEP1	79987	broad.mit.edu	37	9	113233781	113233781	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr9:113233781T>C	uc010mtz.2	-	16	3198	c.2861A>G	c.(2860-2862)AAA>AGA	p.K954R	SVEP1_uc010mua.1_Missense_Mutation_p.K954R	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	954					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GAGAGTCCTTTTCAGTTTATT	0.403		NA											3	40					0	0	0	0
MAOB	4129	broad.mit.edu	37	X	43698134	43698134	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:43698134G>A	uc004dfz.3	-	3	435	c.259C>T	c.(259-261)CGT>TGT	p.R87C	MAOB_uc011mkx.1_Missense_Mutation_p.R71C|MAOB_uc011mky.1_Missense_Mutation_p.R71C|MAOB_uc010nhj.2_Missense_Mutation_p.R87C	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	87	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	TGGATCAGACGCTCAACCTCA	0.433		NA											18	82					0	0	0	0
CCNB3	85417	broad.mit.edu	37	X	50052074	50052074	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:50052074C>G	uc004dox.3	+	6	1203	c.905C>G	c.(904-906)CCA>CGA	p.P302R	CCNB3_uc004doy.2_Missense_Mutation_p.P302R|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	302					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TTTAGGAAGCCACCAGTATTG	0.418		NA											7	73					0	0	0	0
ATG4A	115201	broad.mit.edu	37	X	107393409	107393409	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:107393409A>G	uc004enr.2	+	10	965	c.842A>G	c.(841-843)CAT>CGT	p.H281R	ATG4A_uc004ent.2_Missense_Mutation_p.H219R|ATG4A_uc004ens.2_Missense_Mutation_p.H197R|ATG4A_uc011msl.1_Missense_Mutation_p.H135R|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_Missense_Mutation_p.H197R|COL4A6_uc011msm.1_Intron	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	281		By similarity.			autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						TTGGACCCTCATACAACCCAG	0.493		NA											70	200					0	0	0	0
GPR112	139378	broad.mit.edu	37	X	135430046	135430046	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:135430046T>C	uc004ezu.1	+	6	4472	c.4181T>C	c.(4180-4182)GTG>GCG	p.V1394A	GPR112_uc010nsb.1_Missense_Mutation_p.V1189A|GPR112_uc010nsc.1_Missense_Mutation_p.V1161A	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1394	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CCCAGGACTGTGGAAATGATA	0.453		NA											49	175					0	0	0	0
MAGEA5	4104	broad.mit.edu	37	X	151283638	151283638	+	Nonstop_Mutation	SNP	T	T	G			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chrX:151283638T>G	uc004ffj.2	-	3	580	c.375A>C	c.(373-375)TAA>TAC	p.*125Y		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	125											0	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCCTTGACTTAATACTTGA	0.512		NA											34	136					0	0	0	0
FTSJD1	55783	broad.mit.edu	37	16	71319701	71319705	+	Frame_Shift_Del	DEL	ATTAA	ATTAA	-			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr16:71319701_71319705delATTAA	uc010cga.2	-	3	525_529	c.119_123delTTAAT	c.(118-123)CTTAATfs	p.L40fs	FTSJD1_uc002ezy.3_Frame_Shift_Del_p.L40fs|FTSJD1_uc002ezz.3_Frame_Shift_Del_p.L40fs	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	40_41						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						GCCACTCATTATTAAGTGGCTTGCC	0.41		NA											26	38	---	---	---	---	NA	NA	NA	NA
TUBGCP6	85378	broad.mit.edu	37	22	50656424	50656444	+	In_Frame_Del	DEL	CCCCGCGGGCCCCCAGGGGGC	CCCCGCGGGCCCCCAGGGGGC	-	rs35381394	by1000genomes	TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr22:50656424_50656444delCCCCGCGGGCCCCCAGGGGGC	uc003bkb.1	-	24	5783_5803	c.5271_5291delGCCCCCTGGGGGCCCGCGGGG	c.(5269-5292)GGGCCCCCTGGGGGCCCGCGGGGT>GGT	p.1757_1764GPPGGPRG>G	TUBGCP6_uc003bka.1_In_Frame_Del_p.827_834GPPGGPRG>G|TUBGCP6_uc010har.1_In_Frame_Del_p.1749_1756GPPGGPRG>G|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1757_1764					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTGCTCTGCACCCCGCGGGCCCCCAGGGGGCCCCCAGGCCT	0.624		NA											8	71	---	---	---	---	NA	NA	NA	NA
MAK	4117	broad.mit.edu	37	6	10830857	10830857	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr6:10830857delG	uc003mzl.2	-	1	254	c.25delC	c.(25-27)CAGfs	p.Q9fs	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Frame_Shift_Del_p.Q9fs|MAK_uc010jov.1_RNA	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	9	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				TCCCCCAACTGTCTCATGGTT	0.438		NA											17	86	---	---	---	---	NA	NA	NA	NA
TIGD5	84948	broad.mit.edu	37	8	144680434	144680436	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr8:144680434_144680436delGAG	uc003yyx.1	+	1	214_216	c.214_216delGAG	c.(214-216)GAGdel	p.E74del	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	123					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GCTGGCCAACGAGGAGGAGATCG	0.704		NA											10	36	---	---	---	---	NA	NA	NA	NA
GTF3C4	9329	broad.mit.edu	37	9	135554721	135554722	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-6934-01A-11D-1912-08	TCGA-CV-6934-10A-01D-1912-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f5abf385-0372-4faa-9558-8bf02381b68b	763bd061-65d2-4232-8ffe-2e27a7c6b4b6	g.chr9:135554721_135554722insT	uc010mzv.2	+	2	1973_1974	c.1715_1716insT	c.(1714-1716)TATfs	p.Y572fs	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	572					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GGAGTCACCTATTTTTGGCGTT	0.371		NA											36	160	---	---	---	---	NA	NA	NA	NA