Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
UBR4	23352	broad.mit.edu	37	1	19451143	19451143	+	Silent	SNP	T	T	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr1:19451143T>G	uc001bbi.2	-	65	9484	c.9480A>C	c.(9478-9480)CTA>CTC	p.L3160L	UBR4_uc001bbk.1_Silent_p.L807L	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3160					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCATTTCTGTTAGAAGCTGAG	0.423		NA											14	44					0	0	0	0
LDHD	197257	broad.mit.edu	37	16	75146279	75146279	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr16:75146279A>G	uc002fdm.2	-	11	1546	c.1499T>C	c.(1498-1500)CTC>CCC	p.L500P	LDHD_uc002fdn.2_Missense_Mutation_p.L477P	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	500							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						TGGATTCATGAGGCCTTGGGG	0.622		NA											3	37					0	0	0	0
MYO1D	4642	broad.mit.edu	37	17	30821787	30821787	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr17:30821787G>T	uc002hho.1	-	22	3023	c.3011C>A	c.(3010-3012)CCC>CAC	p.P1004H		NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	1004						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TCAGTTCCCGGGCACGCTGAG	0.682		NA											7	11					0.00198382	0.00566432	1	0
PDYN	5173	broad.mit.edu	37	20	1961249	1961249	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr20:1961249T>G	uc010gaj.2	-	3	727	c.485A>C	c.(484-486)TAT>TCT	p.Y162S	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.Y162S|PDYN_uc010zpt.1_Missense_Mutation_p.Y7S	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	162					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						CTCAGCGAGATAGAGTGTGCC	0.597		NA											5	94					0	0	0	0
PLCB1	23236	broad.mit.edu	37	20	8678323	8678323	+	Silent	SNP	C	C	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr20:8678323C>T	uc002wnb.2	+	11	1063	c.1060C>T	c.(1060-1062)CTG>TTG	p.L354L	PLCB1_uc010zrb.1_Silent_p.L253L|PLCB1_uc002wna.2_Silent_p.L354L|PLCB1_uc002wnc.1_Silent_p.L253L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	354	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCAAGTGCTCCTGTCTGGTTG	0.502		NA											38	86					0	0	0	0
EP300	2033	broad.mit.edu	37	22	41565529	41565529	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr22:41565529G>A	uc003azl.3	+	26	4590	c.4195G>A	c.(4195-4197)GAT>AAT	p.D1399N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1399				D->Y: Does not interact with TFAP2A and inhibits transcriptional coactivation of TFAP2A by CITED2. Does not inhibit interaction with CITED2, DNA-binding of TFAP2A or nuclear localization of TFAP2A or CITED2.	apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399Y(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATCTTACCTCGATAGTGTTCA	0.338		NA	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				32	24					0	0	0	0
PRR23A	729627	broad.mit.edu	37	3	138724434	138724434	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:138724434A>G	uc011bms.1	-	1	677	c.677T>C	c.(676-678)GTC>GCC	p.V226A		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	226	Pro-rich.										0						TGAGCTGGGGACAGGCTCCAG	0.682		NA											6	17					0	0	0	0
KPNA4	3840	broad.mit.edu	37	3	160239585	160239585	+	Silent	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:160239585G>A	uc003fdn.2	-	11	1191	c.885C>T	c.(883-885)CAC>CAT	p.H295H		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	295	ARM 6.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TAACTTCCTGGTGGCTGAGCA	0.388		NA											53	79					0	0	0	0
NAALADL2	254827	broad.mit.edu	37	3	174974236	174974236	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:174974236G>A	uc003fit.2	+	4	943	c.856G>A	c.(856-858)GAT>AAT	p.D286N	NAALADL2_uc003fiu.1_Missense_Mutation_p.D279N|NAALADL2_uc010hwy.1_Missense_Mutation_p.D108N|NAALADL2_uc010hwz.1_5'UTR	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	286	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AATGGCAGATGATTTAAAAAG	0.363		NA											14	78					0	0	0	0
SLC4A4	8671	broad.mit.edu	37	4	72319250	72319250	+	Missense_Mutation	SNP	C	C	G	rs138493429	byFrequency	TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:72319250C>G	uc003hfy.2	+	12	1478	c.1361C>G	c.(1360-1362)GCG>GGG	p.A454G	SLC4A4_uc010iic.2_Missense_Mutation_p.A454G|SLC4A4_uc010iib.2_Missense_Mutation_p.A454G|SLC4A4_uc003hfz.2_Missense_Mutation_p.A454G|SLC4A4_uc003hgc.3_Missense_Mutation_p.A410G|SLC4A4_uc010iid.2_Intron|SLC4A4_uc003hga.2_Missense_Mutation_p.A332G|SLC4A4_uc003hgb.3_Missense_Mutation_p.A410G	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	454	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AAGAGGAAAGCGCCATTTTTT	0.343		NA											28	113					0	0	0	0
ACSL1	2180	broad.mit.edu	37	4	185684332	185684332	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:185684332C>T	uc003iww.2	-	16	1804	c.1510G>A	c.(1510-1512)GGC>AGC	p.G504S	ACSL1_uc011ckm.1_Missense_Mutation_p.G333S|ACSL1_uc003iwt.1_Missense_Mutation_p.G504S|ACSL1_uc003iwu.1_Missense_Mutation_p.G504S|ACSL1_uc011ckn.1_Missense_Mutation_p.G470S|ACSL1_uc003iws.1_Missense_Mutation_p.G74S	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	504	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCGCCCTCGCCCTCGGCAGCC	0.488		NA											10	28					0	0	0	0
ARSI	340075	broad.mit.edu	37	5	149676844	149676844	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr5:149676844C>A	uc003lrv.2	-	2	2232	c.1643G>T	c.(1642-1644)TGC>TTC	p.C548F		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	548						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAAATCTTGCATTTTTTCTT	0.527		NA											48	84					6.62e-31	2.18e-30	1	0
SLC30A8	169026	broad.mit.edu	37	8	118170064	118170064	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr8:118170064G>A	uc003yoh.2	+	4	783	c.553G>A	c.(553-555)GCA>ACA	p.A185T	SLC30A8_uc010mcz.2_Missense_Mutation_p.A136T|SLC30A8_uc011lia.1_Missense_Mutation_p.A136T|SLC30A8_uc003yog.2_Missense_Mutation_p.A136T	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	185	Helical; (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TTCCAGCTGCGCAGTGGCGGC	0.527		NA											37	69					0	0	0	0
CLCN4	1183	broad.mit.edu	37	X	10201603	10201603	+	Silent	SNP	C	C	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chrX:10201603C>T	uc004csy.3	+	13	2692	c.2262C>T	c.(2260-2262)CCC>CCT	p.P754P	CLCN4_uc011mid.1_Silent_p.P660P	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	754	CBS 2.|Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ACCAGGACCCCGAATCCATCA	0.363		NA											4	40					0	0	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46099783	46099784	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr1:46099783_46099784insA	uc001coq.2	-	9	2230_2231	c.869_870insT	c.(868-870)CTGfs	p.L290fs	GPBP1L1_uc001coo.2_Frame_Shift_Ins_p.L34fs	NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGGGAGAACTCAGAGCTGCACC	0.465		NA											22	56	---	---	---	---	NA	NA	NA	NA
ALPK3	57538	broad.mit.edu	37	15	85383922	85383922	+	Frame_Shift_Del	DEL	C	C	-	rs143709902	byFrequency	TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr15:85383922delC	uc002ble.2	+	5	2185	c.2018delC	c.(2017-2019)ACCfs	p.T673fs		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	673					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CACTCCTTGACCCCCCAGCCG	0.617		NA											17	55	---	---	---	---	NA	NA	NA	NA
IL34	146433	broad.mit.edu	37	16	70693992	70693993	+	Frame_Shift_Ins	INS	-	-	AGCTG			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr16:70693992_70693993insAGCTG	uc002ezh.1	+	6	1014_1015	c.631_632insAGCTG	c.(631-633)CAGfs	p.Q211fs	IL34_uc002ezi.1_Frame_Shift_Ins_p.Q210fs	NM_152456	NP_689669	Q6ZMJ4	IL34_HUMAN	interleukin 34 precursor	211					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2						TGCGGCCACCCAGCTGTACCCT	0.649		NA											24	120	---	---	---	---	NA	NA	NA	NA
ALK	238	broad.mit.edu	37	2	29451771	29451772	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr2:29451771_29451772delCA	uc002rmy.2	-	16	3700_3701	c.2793_2794delTG	c.(2791-2796)GGTGGAfs	p.G931fs		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	931_932	Gly-rich.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCGCCTCCTCCACCTGAGGAGC	0.545		NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				12	33	---	---	---	---	NA	NA	NA	NA
C3orf1	51300	broad.mit.edu	37	3	119219666	119219667	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr3:119219666_119219667insAG	uc003ecn.2	+	2	532_533	c.319_320insAG	c.(319-321)CAGfs	p.Q107fs	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	107						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		ATACATTGAGCAGAGCCAGGCA	0.421		NA											42	66	---	---	---	---	NA	NA	NA	NA
FSTL5	56884	broad.mit.edu	37	4	162307557	162307558	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr4:162307557_162307558insT	uc003iqh.2	-	16	2321_2322	c.1885_1886insA	c.(1885-1887)ATTfs	p.I629fs	FSTL5_uc003iqi.2_Frame_Shift_Ins_p.I628fs|FSTL5_uc010iqv.2_Frame_Shift_Ins_p.I619fs|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	629						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCAAGATCAATTTTTTGTAGT	0.361		NA											13	36	---	---	---	---	NA	NA	NA	NA
C8orf80	389643	broad.mit.edu	37	8	27925899	27925899	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CV-7100-01A-11D-2012-08	TCGA-CV-7100-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	f21a5e1f-84b8-4e6f-8230-03d31cc7c431	3951a376-81b0-4843-b3c0-ca1b0f6efffb	g.chr8:27925899delA	uc003xgm.3	-	5	457	c.314delT	c.(313-315)TTAfs	p.L105fs		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	105						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		GCTTCCAAATAATGCAATGTA	0.433		NA											2	4	---	---	---	---	NA	NA	NA	NA