Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MTHFR	4524	broad.mit.edu	37	1	11854027	11854027	+	Silent	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:11854027G>A	uc001atc.1	-	9	1651	c.1467C>T	c.(1465-1467)AAC>AAT	p.N489N	MTHFR_uc001atb.1_Silent_p.N512N	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	489					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	ACGGCTTCCCGTTGATGTTGG	0.657		NA											35	73					0	0	0	0
C1orf113	79729	broad.mit.edu	37	1	36785374	36785374	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:36785374C>T	uc010oia.1	+	14	1138	c.1110C>T	c.(1108-1110)AAC>AAT	p.N370N	C1orf113_uc010oib.1_Silent_p.N259N|C1orf113_uc010oic.1_RNA|C1orf113_uc009vuz.1_Silent_p.N16N	NM_001162530	NP_001156002	A4FU49	SH321_HUMAN	SH3 domain-containing protein C1orf113 isoform	254											0		Myeloproliferative disorder(586;0.0393)				CTCCAGAGAACGCCCCCAGCT	0.622		NA											12	23					0	0	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46096158	46096159	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:46096158_46096159GC>AA	uc001coq.2	-	11	2525_2526	c.1164_1165GC>TT	c.(1162-1167)GAGCAC>GATTAC	p.388_389EH>DY	GPBP1L1_uc001coo.2_Missense_Mutation_p.132_133EH>DY	NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	388_389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACTTACCTGTGCTCTGCTTCTA	0.49		NA											18	69					0	0	0	0
LRRC41	10489	broad.mit.edu	37	1	46751227	46751227	+	Silent	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:46751227T>C	uc001cpn.2	-	4	1346	c.1302A>G	c.(1300-1302)GAA>GAG	p.E434E	LRRC41_uc010omb.1_Silent_p.E434E|LRRC41_uc001cpo.1_Silent_p.E434E	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	434										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CACAAGCCACTTCCCCAATCT	0.547		NA											34	57					0	0	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279983	47279983	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:47279983C>T	uc001cqm.3	+	7	959	c.875C>T	c.(874-876)GCC>GTC	p.A292V	CYP4B1_uc009vyl.1_Missense_Mutation_p.A129V|CYP4B1_uc001cqn.3_Missense_Mutation_p.A293V|CYP4B1_uc009vym.2_Missense_Mutation_p.A278V|CYP4B1_uc010omk.1_Missense_Mutation_p.A129V|CYP4B1_uc010oml.1_Missense_Mutation_p.A130V	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	292					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CTCCTGGGTGCCCGGGTGAGT	0.582		NA											12	16					0	0	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52940829	52940829	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:52940829G>C	uc001ctx.2	-	13	2636	c.2402C>G	c.(2401-2403)TCT>TGT	p.S801C	ZCCHC11_uc001cty.2_Missense_Mutation_p.S801C|ZCCHC11_uc001ctz.2_Missense_Mutation_p.S801C|ZCCHC11_uc009vze.1_Missense_Mutation_p.S801C|ZCCHC11_uc009vzf.1_Missense_Mutation_p.S560C|ZCCHC11_uc001cub.2_Missense_Mutation_p.S801C	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	801					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTGCTGGTAGAAAGAGATGA	0.358		NA											23	133					0	0	0	0
AK5	26289	broad.mit.edu	37	1	77806144	77806144	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:77806144A>G	uc001dhn.2	+	6	1039	c.782A>G	c.(781-783)CAG>CGG	p.Q261R	AK5_uc001dho.2_Missense_Mutation_p.Q235R	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	261					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						GCAGAACAGCAGGGCCGACCA	0.468		NA											24	91					0	0	0	0
PTBP2	58155	broad.mit.edu	37	1	97236288	97236288	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:97236288G>A	uc001drq.2	+	5	559	c.313G>A	c.(313-315)GAA>AAA	p.E105K	PTBP2_uc001drn.2_Missense_Mutation_p.E105K|PTBP2_uc001dro.2_Missense_Mutation_p.E105K|PTBP2_uc010otz.1_Missense_Mutation_p.E116K|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.E53K|PTBP2_uc001drr.2_Missense_Mutation_p.E105K|PTBP2_uc010oua.1_Missense_Mutation_p.E113K|PTBP2_uc001dru.2_RNA|PTBP2_uc001drm.2_Missense_Mutation_p.E105K	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	105	RRM 1.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		AGCAACCGAGGAAGCAGCTAT	0.303		NA											21	55					0	0	0	0
PHTF1	10745	broad.mit.edu	37	1	114267424	114267424	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:114267424C>T	uc009wgp.1	-	6	1032	c.580G>A	c.(580-582)GTA>ATA	p.V194I	PHTF1_uc001edn.2_Missense_Mutation_p.V194I|PHTF1_uc010own.1_Missense_Mutation_p.V194I	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	194						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAATGGGTACAGATTCCAAA	0.353		NA											25	42					0	0	0	0
WARS2	10352	broad.mit.edu	37	1	119683180	119683180	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:119683180G>A	uc001ehn.2	-	1	116	c.88C>T	c.(88-90)CAG>TAG	p.Q30*	WARS2_uc010oxf.1_5'Flank|WARS2_uc001ehm.2_Nonsense_Mutation_p.Q30*|WARS2_uc010oxg.1_Nonsense_Mutation_p.Q30*|WARS2_uc010oxh.1_Nonsense_Mutation_p.Q30*|WARS2_uc010oxi.1_5'Flank|uc001ehp.1_RNA|uc001eho.1_RNA|uc009whk.1_RNA	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	30					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	TTGGTTACCTGGAGAGCGGGA	0.597		NA											6	31					0	0	0	0
OR6K2	81448	broad.mit.edu	37	1	158669807	158669807	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:158669807C>T	uc001fsu.1	-	1	636	c.636G>A	c.(634-636)GTG>GTA	p.V212V		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGATGAGCATCACAGCTGTAA	0.498		NA											24	99					0	0	0	0
LAMC1	3915	broad.mit.edu	37	1	183106849	183106849	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:183106849G>A	uc001gpy.3	+	26	4617	c.4360G>A	c.(4360-4362)GTT>ATT	p.V1454I		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1454	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTTGCAGAAGTTACAGATCT	0.383		NA											8	39					0	0	0	0
PTPRC	5788	broad.mit.edu	37	1	198665840	198665840	+	Splice_Site	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr1:198665840G>A	uc001gur.1	+	4	275	c.95_splice	c.e4-1	p.G32_splice	PTPRC_uc001gus.1_Splice_Site_p.G32_splice|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Intron|PTPRC_uc009wzf.1_Intron|PTPRC_uc010ppg.1_Intron|PTPRC_uc001guu.1_Splice_Site_p.R75_splice|PTPRC_uc001guv.1_Intron|PTPRC_uc001guw.1_Intron	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C						axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTAATTAACAGGATTGACTAC	0.418		NA											32	83					0	0	0	0
MBL2	4153	broad.mit.edu	37	10	54528241	54528241	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:54528241C>T	uc001jjt.2	-	4	468	c.403G>A	c.(403-405)GGG>AGG	p.G135R		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	135	C-type lectin.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						AACTTGTTCCCAACTTGTTTG	0.453		NA											18	103					0	0	0	0
MYST4	23522	broad.mit.edu	37	10	76788252	76788252	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:76788252A>G	uc001jwn.1	+	18	4163	c.3670A>G	c.(3670-3672)ATG>GTG	p.M1224V	MYST4_uc001jwo.1_Missense_Mutation_p.M932V|MYST4_uc001jwp.1_Missense_Mutation_p.M1041V	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1224					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CTAAGACAATATGAATGATGA	0.373		NA	T	CREBBP	AML								16	116					0	0	0	0
DUPD1	338599	broad.mit.edu	37	10	76797686	76797686	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:76797686T>G	uc001jwq.1	-	3	571	c.571A>C	c.(571-573)AAG>CAG	p.K191Q		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	191	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CGGAGCTGCTTCAAAAAGCCC	0.642		NA											19	65					0	0	0	0
C10orf12	26148	broad.mit.edu	37	10	98742212	98742212	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:98742212C>T	uc001kmv.2	+	1	1172	c.1065C>T	c.(1063-1065)CCC>CCT	p.P355P	C10orf12_uc009xvg.1_Silent_p.P665P	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	355										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGAGTGTACCCCAGGACTGTC	0.522		NA											37	80					0	0	0	0
GFRA1	2674	broad.mit.edu	37	10	118030435	118030435	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:118030435G>A	uc001lcj.2	-	3	931	c.233C>T	c.(232-234)GCC>GTC	p.A78V	GFRA1_uc001lci.2_Missense_Mutation_p.A78V|GFRA1_uc009xyr.2_Missense_Mutation_p.A78V	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	78	1				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTGCTTCAGGGCCTCCATGGC	0.602		NA											13	34					0	0	0	0
PDZD8	118987	broad.mit.edu	37	10	119043244	119043244	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:119043244C>A	uc001lde.1	-	5	3199	c.3000G>T	c.(2998-3000)AAG>AAT	p.K1000N		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1000					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TTCTCACTAACTTTATTCCTG	0.478		NA											88	167					2.93e-44	8.54e-44	1	0
GRK5	2869	broad.mit.edu	37	10	121212266	121212266	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr10:121212266C>T	uc001led.2	+	14	1721	c.1488C>T	c.(1486-1488)GAC>GAT	p.D496D	GRK5_uc009xzh.2_Silent_p.D361D	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	496	AGC-kinase C-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		ACACAGACGACGACTTCTACT	0.597		NA											9	25					0	0	0	0
MUC5B	727897	broad.mit.edu	37	11	1272638	1272638	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:1272638G>A	uc009ycr.1	+	52	15620	c.15494G>A	c.(15493-15495)GGG>GAG	p.G5165E	MUC5B_uc001ltb.2_Missense_Mutation_p.G4846E	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4843	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCACCCCAGGGACCACCTGG	0.637		NA											52	84					0	0	0	0
SPRYD5	84767	broad.mit.edu	37	11	55653067	55653067	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:55653067T>G	uc010rip.1	+	2	255	c.163T>G	c.(163-165)TGC>GGC	p.C55G	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	55	RING-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GTGCTCTGAATGCAAGAAGAC	0.507		NA											7	38					0	0	0	0
PYGM	5837	broad.mit.edu	37	11	64519456	64519456	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:64519456G>A	uc001oax.3	-	14	2525	c.1708C>T	c.(1708-1710)CGG>TGG	p.R570W	PYGM_uc001oay.3_Missense_Mutation_p.R482W	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	570					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	TCGTGAATCCGCTTCACCTGG	0.512		NA											15	81					0	0	0	0
CLCF1	23529	broad.mit.edu	37	11	67134940	67134940	+	Silent	SNP	A	A	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:67134940A>T	uc001okq.2	-	2	370	c.174T>A	c.(172-174)GCT>GCA	p.A58A	LOC100130987_uc010rpo.1_Intron|CLCF1_uc010rpp.1_Silent_p.A48A	NM_013246	NP_037378	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1 precursor	58					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity				0			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			CATAGGTCCCAGCCAAGCTGC	0.577		NA											38	68					0	0	0	0
MMP20	9313	broad.mit.edu	37	11	102480739	102480739	+	Silent	SNP	G	G	A	rs148659857	byFrequency	TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:102480739G>A	uc001phc.2	-	4	559	c.546C>T	c.(544-546)TTC>TTT	p.F182F		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	182					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GAGGCCCATCGAATGGATAGG	0.498		NA											8	40					0	0	0	0
PCSK7	9159	broad.mit.edu	37	11	117095455	117095455	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:117095455C>T	uc001pqr.2	-	7	1078	c.877G>A	c.(877-879)GAT>AAT	p.D293N		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	293	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GTCTTCCCATCGTCATCTGGT	0.577		NA	T	IGH@	MLCLS								50	191					0	0	0	0
DSCAML1	57453	broad.mit.edu	37	11	117303096	117303096	+	Silent	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:117303096G>A	uc001prh.1	-	30	5333	c.5331C>T	c.(5329-5331)ATC>ATT	p.I1777I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1717	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGACATGTCGATGAGGGGTC	0.572		NA											6	42					0	0	0	0
TBCEL	219899	broad.mit.edu	37	11	120925792	120925792	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:120925792T>C	uc009zay.2	+	5	565	c.487T>C	c.(487-489)TAT>CAT	p.Y163H	TBCEL_uc001pxo.2_Missense_Mutation_p.Y163H|TBCEL_uc001pxp.2_Missense_Mutation_p.Y19H|TBCEL_uc001pxq.2_Intron	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	163	LRR 4.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		CCTTAATGACTATGAAACAGT	0.343		NA											10	46					0	0	0	0
NRGN	4900	broad.mit.edu	37	11	124615418	124615418	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr11:124615418C>T	uc001qaq.2	+	2	187	c.35C>T	c.(34-36)CCG>CTG	p.P12L	NRGN_uc001qar.2_Missense_Mutation_p.P12L	NM_006176	NP_006167	Q92686	NEUG_HUMAN	neurogranin	12					nervous system development|signal transduction		calmodulin binding				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TGCTCCAAGCCGGACGACGAC	0.647		NA											9	56					0	0	0	0
MGP	4256	broad.mit.edu	37	12	15035958	15035958	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:15035958C>T	uc001rcn.1	-	3	221	c.118G>A	c.(118-120)GCA>ACA	p.A40T		NM_000900	NP_000891	P08493	MGP_HUMAN	matrix Gla protein precursor	40					cartilage condensation|cell differentiation|ossification|regulation of bone mineralization	proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent|structural constituent of bone			ovary(1)	1						AAGGTATTTGCATTTCTCCTG	0.383		NA											11	32					0	0	0	0
PDE3A	5139	broad.mit.edu	37	12	20782996	20782996	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:20782996A>T	uc001reh.1	+	6	1717	c.1695A>T	c.(1693-1695)TTA>TTT	p.L565F		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	565					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ACAGGGCCTTAACTTACACTC	0.453		NA											77	121					0	0	0	0
NUP107	57122	broad.mit.edu	37	12	69083344	69083344	+	Silent	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:69083344T>C	uc001suf.2	+	3	247	c.132T>C	c.(130-132)AAT>AAC	p.N44N	uc001sud.1_5'Flank|uc001sue.1_5'Flank|NUP107_uc001sug.2_5'UTR|NUP107_uc010stj.1_Missense_Mutation_p.I6T	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	44					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			ATTTTGGTAATACTACACCAA	0.328		NA											16	48					0	0	0	0
ANO4	121601	broad.mit.edu	37	12	101295618	101295618	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:101295618G>A	uc010svm.1	+	2	627	c.55G>A	c.(55-57)GAA>AAA	p.E19K	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.V19M|ANO4_uc001thx.2_Missense_Mutation_p.E19K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	19	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CTTCCACCCAGGTGATGCATG	0.443		NA								HNSCC(74;0.22)			29	69					0	0	0	0
PTPN11	5781	broad.mit.edu	37	12	112940025	112940025	+	Silent	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:112940025T>C	uc001ttx.2	+	14	2057	c.1677T>C	c.(1675-1677)CCT>CCC	p.P559P		NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	563					axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						ATCAGAGCCCTCTCCCGCCTT	0.423		NA	Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				5	162					0	0	0	0
DTX1	1840	broad.mit.edu	37	12	113496166	113496166	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:113496166C>T	uc001tuk.1	+	1	505	c.169C>T	c.(169-171)CGC>TGC	p.R57C		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	57	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GGAGGACGCTCGCGGTTCCGT	0.642		NA											26	101					0	0	0	0
SYNE2	23224	broad.mit.edu	37	14	64522880	64522880	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr14:64522880C>T	uc001xgm.2	+	49	10193	c.9963C>T	c.(9961-9963)TCC>TCT	p.S3321S	SYNE2_uc001xgl.2_Silent_p.S3321S|SYNE2_uc010apw.1_Silent_p.S27S	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3321	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAATGATATCCAGCCCCGAAG	0.433		NA											8	31					0	0	0	0
TJP1	7082	broad.mit.edu	37	15	30008972	30008972	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr15:30008972C>T	uc001zcr.2	-	23	4520	c.4045G>A	c.(4045-4047)GAA>AAA	p.E1349K	TJP1_uc010azl.2_Missense_Mutation_p.E1337K|TJP1_uc001zcq.2_Missense_Mutation_p.E1273K|TJP1_uc001zcs.2_Missense_Mutation_p.E1269K	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1349					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCATCTTCTTCAGGGTCATAA	0.428		NA											9	46					0	0	0	0
UBR1	197131	broad.mit.edu	37	15	43360173	43360173	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr15:43360173C>T	uc001zqq.2	-	6	787	c.721G>A	c.(721-723)GTC>ATC	p.V241I	UBR1_uc010udk.1_Missense_Mutation_p.V241I	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	241					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		CTGTATATGACGTGGTCATAT	0.383		NA											11	83					0	0	0	0
NHLRC4	283948	broad.mit.edu	37	16	618123	618123	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr16:618123G>A	uc002chl.2	+	2	672	c.76G>A	c.(76-78)GAT>AAT	p.D26N	PIGQ_uc010bqw.2_Intron|PIGQ_uc002chm.2_5'Flank|PIGQ_uc002chn.2_5'Flank|PIGQ_uc002cho.2_5'Flank	NM_176677	NP_788850	P0CG21	NHLC4_HUMAN	hypothetical protein LOC283948	26											0						GGAGTTTGGGGATGTGAGGCT	0.687		NA											6	14					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18828771	18828771	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr16:18828771T>C	uc002dfm.2	-	57	10279	c.9916A>G	c.(9916-9918)ATC>GTC	p.I3306V	SMG1_uc010bwb.2_Missense_Mutation_p.I3166V|SMG1_uc010bwa.2_Missense_Mutation_p.I2037V	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3306					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AAATGAATGATATTGCTGCAG	0.413		NA											2	8					0	0	0	0
GTF3C1	2975	broad.mit.edu	37	16	27544670	27544670	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr16:27544670A>T	uc002dov.1	-	5	831	c.791T>A	c.(790-792)GTC>GAC	p.V264D	GTF3C1_uc002dou.2_Missense_Mutation_p.V264D	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	264						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCTCAGCATGACCGAAAGCTT	0.522		NA											21	54					0	0	0	0
NUP88	4927	broad.mit.edu	37	17	5290067	5290067	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:5290067G>A	uc002gbo.1	-	16	2149	c.2123C>T	c.(2122-2124)GCC>GTC	p.A708V	NUP88_uc002gbn.2_5'Flank|NUP88_uc010vsx.1_Missense_Mutation_p.A724V	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	708					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						TCGCTGGTAGGCACTGAGAAT	0.368		NA											32	46					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7579378	7579378	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:7579378G>C	uc002gim.2	-	4	503	c.309C>G	c.(307-309)TAC>TAG	p.Y103*	TP53_uc002gig.1_Nonsense_Mutation_p.Y103*|TP53_uc002gih.2_Nonsense_Mutation_p.Y103*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.Y103*|TP53_uc010cni.1_Nonsense_Mutation_p.Y103*|TP53_uc002gij.2_Nonsense_Mutation_p.Y103*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.Y64*|TP53_uc010cnk.1_Nonsense_Mutation_p.Y118*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	103	Interaction with HIPK1 (By similarity).||Interaction with WWOX.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.G59fs*23(3)|p.Y103*(2)|p.V73fs*9(1)|p.Y103Y(1)|p.Y103_Q104>**(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGCTGCCCTGGTAGGTTTTCT	0.637		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	46					0	0	0	0
CHD3	1107	broad.mit.edu	37	17	7802768	7802768	+	Silent	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:7802768G>A	uc002gje.2	+	15	2601	c.2451G>A	c.(2449-2451)ACG>ACA	p.T817T	CHD3_uc002gjd.2_Silent_p.T876T|CHD3_uc002gjf.2_Silent_p.T817T	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	817	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TGACATACACGGGTGACAAGG	0.498		NA											43	78					0	0	0	0
MYH10	4628	broad.mit.edu	37	17	8398540	8398540	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:8398540G>A	uc002gll.2	-	29	3974	c.3878C>T	c.(3877-3879)TCC>TTC	p.S1293F	MYH10_uc002glm.2_Missense_Mutation_p.S1324F|MYH10_uc010cnx.2_Missense_Mutation_p.S1302F	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1293	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CAGAAGGGTGGAGACATTATC	0.413		NA											11	22					0	0	0	0
GAS2L2	246176	broad.mit.edu	37	17	34077293	34077293	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:34077293C>A	uc002hjv.1	-	2	458	c.430G>T	c.(430-432)GTG>TTG	p.V144L		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	144	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACGTTCTTCACGTTCTTGCGC	0.642		NA											34	235					6.29e-14	1.8e-13	1	0
KRT39	390792	broad.mit.edu	37	17	39118751	39118751	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:39118751G>A	uc002hvo.1	-	4	809	c.773C>T	c.(772-774)TCT>TTT	p.S258F	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	258	Linker 12.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				TAGGTCAGCAGAAGGGGCAGC	0.448		NA											129	256					0	0	0	0
STAT5B	6777	broad.mit.edu	37	17	40359689	40359689	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:40359689G>T	uc002hzh.2	-	16	2133	c.1964C>A	c.(1963-1965)TCC>TAC	p.S655Y		NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	655	SH2.				2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GTCGGCTAGGGACCGAATGGA	0.418		NA											13	46					7.04e-09	1.96e-08	1	0
TUBD1	51174	broad.mit.edu	37	17	57951968	57951968	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:57951968G>A	uc002ixw.1	-	6	1144	c.866C>T	c.(865-867)ACA>ATA	p.T289I	TUBD1_uc010ddf.1_Intron|TUBD1_uc010ddg.1_Missense_Mutation_p.T254I|TUBD1_uc010ddh.1_Intron|TUBD1_uc010wok.1_Missense_Mutation_p.T289I|TUBD1_uc002ixx.1_Intron|TUBD1_uc010wol.1_Missense_Mutation_p.T73I|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	289					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			CCAAGTAAATGTGGTGTATGC	0.423		NA											31	218					0	0	0	0
SOX9	6662	broad.mit.edu	37	17	70120341	70120341	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:70120341C>T	uc002jiw.2	+	3	1715	c.1343C>T	c.(1342-1344)TCC>TTC	p.S448F		NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	448					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CACCAGAACTCCAGCTCCTAC	0.637		NA											21	151					0	0	0	0
ENOSF1	55556	broad.mit.edu	37	18	683302	683302	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:683302A>C	uc002kku.3	-	11	895	c.820T>G	c.(820-822)TGG>GGG	p.W274G	ENOSF1_uc002kkt.3_Missense_Mutation_p.W192G|ENOSF1_uc010dke.2_RNA|ENOSF1_uc010dkf.2_Missense_Mutation_p.W295G|ENOSF1_uc002kkv.3_Missense_Mutation_p.W261G|ENOSF1_uc002kkw.3_Missense_Mutation_p.W93G|ENOSF1_uc002kkx.3_Missense_Mutation_p.W198G	NM_017512	NP_059982	Q7L5Y1	ENOF1_HUMAN	enolase superfamily 1 isoform rTS beta	274					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			ovary(1)	1						TCCTCAATCCACAATGGCTTG	0.532		NA											35	73					0	0	0	0
LAMA1	284217	broad.mit.edu	37	18	6956637	6956637	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:6956637G>A	uc002knm.2	-	56	8186	c.8092C>T	c.(8092-8094)CCA>TCA	p.P2698S	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Missense_Mutation_p.P151S|LAMA1_uc010wzj.1_Missense_Mutation_p.P2174S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2698					axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTCCTACTGGAAAAGCCCGG	0.572		NA											13	77					0	0	0	0
VPS4B	9525	broad.mit.edu	37	18	61074674	61074674	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:61074674G>A	uc002lix.2	-	4	615	c.355C>T	c.(355-357)CAA>TAA	p.Q119*	VPS4B_uc010dpx.2_Nonsense_Mutation_p.Q119*|VPS4B_uc010dpy.2_Intron|VPS4B_uc010dpz.1_Intron	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	119					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						CCTTGAAGTTGATTCTGTAGT	0.289		NA											5	14					0	0	0	0
RTTN	25914	broad.mit.edu	37	18	67687941	67687941	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr18:67687941C>T	uc002lkp.2	-	45	6131	c.6063G>A	c.(6061-6063)ATG>ATA	p.M2021I	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.M1109I|RTTN_uc002lkn.2_Missense_Mutation_p.M11I|RTTN_uc010dqp.2_Missense_Mutation_p.M273I	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	2021							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TCTCCAGTGGCATCTGGGAAG	0.468		NA											19	115					0	0	0	0
EVI5L	115704	broad.mit.edu	37	19	7916351	7916351	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr19:7916351G>A	uc002min.2	+	7	939	c.785G>A	c.(784-786)CGT>CAT	p.R262H	EVI5L_uc010xjz.1_Missense_Mutation_p.R262H|EVI5L_uc002mio.1_5'UTR	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	262	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						ACCCACTTCCGTTCCCAAAGC	0.637		NA											39	81					0	0	0	0
GIPC1	10755	broad.mit.edu	37	19	14593541	14593541	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr19:14593541T>C	uc002myt.2	-	4	518	c.248A>G	c.(247-249)TAT>TGT	p.Y83C	GIPC1_uc002myu.2_Missense_Mutation_p.Y83C|GIPC1_uc002myv.2_Intron|GIPC1_uc002myw.2_Intron|GIPC1_uc002myx.2_Missense_Mutation_p.Y83C|GIPC1_uc002myy.2_Intron	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	83					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						GATCTTGCCATACAGCTCCTT	0.682		NA											8	26					0	0	0	0
ZNF331	55422	broad.mit.edu	37	19	54080198	54080198	+	Silent	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr19:54080198G>A	uc002qbx.1	+	7	1818	c.384G>A	c.(382-384)GAG>GAA	p.E128E	ZNF331_uc002qby.1_Silent_p.E128E|ZNF331_uc002qbz.1_Silent_p.E128E|ZNF331_uc002qca.1_Silent_p.E128E|ZNF331_uc010eqr.1_Silent_p.E128E|ZNF331_uc002qcb.1_Silent_p.E128E|ZNF331_uc002qcc.1_Silent_p.E128E|ZNF331_uc002qcd.1_Silent_p.E128E	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		ATCATAAGGAGAATTCCTTTG	0.418		NA	T	?	follicular thyroid adenoma								41	90					0	0	0	0
SOX11	6664	broad.mit.edu	37	2	5833737	5833737	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:5833737A>T	uc002qyj.2	+	1	939	c.884A>T	c.(883-885)GAC>GTC	p.D295V		NM_003108	NP_003099	P35716	SOX11_HUMAN	SRY-box 11	295					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(3)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		AGCCTCTACGACGAGGTGCGG	0.711		NA											3	5					0	0	0	0
IFT172	26160	broad.mit.edu	37	2	27688750	27688750	+	Splice_Site	SNP	C	C	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:27688750C>A	uc002rku.2	-	17	1744	c.1693_splice	c.e17-1	p.G565_splice		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog						cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TAACATCACCCTGTAAAAGTT	0.507		NA											8	342					0.00307968	0.00831424	1	0
NRXN1	9378	broad.mit.edu	37	2	50149201	50149201	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:50149201G>A	uc010fbp.2	-	6	2017	c.1210C>T	c.(1210-1212)CGA>TGA	p.R404*	NRXN1_uc002rxb.3_Nonsense_Mutation_p.R1138*|NRXN1_uc010fbq.2_Nonsense_Mutation_p.R1509*|NRXN1_uc002rxe.3_Nonsense_Mutation_p.R1439*|NRXN1_uc010yon.1_Nonsense_Mutation_p.R104*|NRXN1_uc002rxa.3_Nonsense_Mutation_p.R101*	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	404	Cytoplasmic (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding	p.R404L(1)		ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATGTAGTTTCGACTCTCGTCC	0.478		NA											37	60					0	0	0	0
RNF103	7844	broad.mit.edu	37	2	86831161	86831161	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:86831161A>C	uc002srn.2	-	4	2832	c.1863T>G	c.(1861-1863)TGT>TGG	p.C621W	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Missense_Mutation_p.C482W|uc002sro.2_RNA	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	621	RING-type.			C->S: Loss of E2-dependent ubiquitination.	central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						GGCAAACAACACATTCAGTAC	0.423		NA											22	166					0	0	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131890487	131890487	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:131890487T>C	uc002tsg.3	+	6	906	c.346T>C	c.(346-348)TCT>CCT	p.S116P	PLEKHB2_uc002tsh.2_Missense_Mutation_p.S116P|PLEKHB2_uc002tsj.3_Missense_Mutation_p.S116P|PLEKHB2_uc002tsf.3_Missense_Mutation_p.S116P|PLEKHB2_uc010zao.1_Missense_Mutation_p.S66P|PLEKHB2_uc010zap.1_Missense_Mutation_p.S116P|PLEKHB2_uc010zaq.1_Intron|PLEKHB2_uc002tsi.3_Missense_Mutation_p.S157P	NM_001100623	NP_001094093	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B	116						membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.0828)		GTATGTGGGCTCTGCAGTCAT	0.572		NA											31	85					0	0	0	0
LCT	3938	broad.mit.edu	37	2	136570169	136570169	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:136570169G>A	uc002tuu.1	-	7	2076	c.2065C>T	c.(2065-2067)CGC>TGC	p.R689C		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	689	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTGATGAGGCGGGAGGTGTAA	0.557		NA											20	55					0	0	0	0
KIF5C	3800	broad.mit.edu	37	2	149806405	149806405	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:149806405A>G	uc010zbu.1	+	9	1135	c.767A>G	c.(766-768)AAT>AGT	p.N256S	KIF5C_uc002tws.1_RNA	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	256	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		AAAAATATCAATAAGTCTTTG	0.453		NA											9	44					0	0	0	0
SP5	389058	broad.mit.edu	37	2	171573597	171573597	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:171573597A>C	uc002uge.2	+	2	1046	c.880A>C	c.(880-882)AAG>CAG	p.K294Q		NM_001003845	NP_001003845	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGGAAGAAGAAGCAGCACGT	0.741		NA											3	9					0	0	0	0
MAP1D	254042	broad.mit.edu	37	2	172942597	172942597	+	Silent	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:172942597T>C	uc002uhk.2	+	7	850	c.777T>C	c.(775-777)CAT>CAC	p.H259H	MAP1D_uc010zdw.1_Silent_p.H141H	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	259		Substrate (By similarity).			N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CTTACTTTCATGGACATCCAG	0.383		NA											22	40					0	0	0	0
AGPS	8540	broad.mit.edu	37	2	178388494	178388494	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:178388494A>G	uc002ull.2	+	19	1863	c.1816A>G	c.(1816-1818)ATC>GTC	p.I606V	AGPS_uc010zfb.1_Missense_Mutation_p.I516V	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	606					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			TAGAGAAGAAATCCTTGCTAA	0.358		NA											18	58					0	0	0	0
NDUFS1	4719	broad.mit.edu	37	2	206988923	206988923	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:206988923G>A	uc002vbe.2	-	19	2297	c.2170C>T	c.(2170-2172)CCA>TCA	p.P724S	NDUFS1_uc010ziq.1_Missense_Mutation_p.P738S|NDUFS1_uc010zir.1_Missense_Mutation_p.P688S|NDUFS1_uc010zis.1_Missense_Mutation_p.P667S|NDUFS1_uc010zit.1_Missense_Mutation_p.P613S|NDUFS1_uc010ziu.1_Missense_Mutation_p.P608S	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	724					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	CATATGGATGGTTCCTCTACT	0.418		NA											15	46					0	0	0	0
ANKZF1	55139	broad.mit.edu	37	2	220098107	220098107	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:220098107C>T	uc002vkg.2	+	7	945	c.771C>T	c.(769-771)CAC>CAT	p.H257H	ANKZF1_uc010zkv.1_Silent_p.H201H|ANKZF1_uc010zkw.1_Silent_p.H47H|ANKZF1_uc002vkh.2_Silent_p.H47H|ANKZF1_uc002vki.2_Silent_p.H257H|ANKZF1_uc002vkj.1_Silent_p.H245H	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	257						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCATCACACTCTGCTGGAG	0.522		NA											17	52					0	0	0	0
ALPPL2	251	broad.mit.edu	37	2	233272011	233272011	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr2:233272011C>T	uc002vss.3	+	3	253	c.200C>T	c.(199-201)ACG>ATG	p.T67M		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	67					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GGGGTGTCTACGGTGACAGCT	0.627		NA											22	59					0	0	0	0
C20orf54	113278	broad.mit.edu	37	20	744241	744241	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:744241G>A	uc002wed.3	-	3	1313	c.974C>T	c.(973-975)TCC>TTC	p.S325F	C20orf54_uc002wee.2_Missense_Mutation_p.S325F	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	325					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GGACAGGCAGGAGTAGGTCTG	0.627		NA											22	118					0	0	0	0
BMP2	650	broad.mit.edu	37	20	6759194	6759194	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:6759194A>G	uc002wmu.1	+	3	1434	c.649A>G	c.(649-651)ACT>GCT	p.T217A		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	217					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	GATGCGGTGGACTGCACAGGG	0.522		NA											4	49					0	0	0	0
RIMS4	140730	broad.mit.edu	37	20	43385559	43385559	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:43385559G>A	uc002xms.2	-	5	571	c.571C>T	c.(571-573)CCC>TCC	p.P191S	RIMS4_uc010ggu.2_Missense_Mutation_p.P192S	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	191	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				TTGCCCTGGGGACTCTCAGGA	0.567		NA											139	217					0	0	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20127348	20127348	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:20127348G>A	uc002zrq.2	+	4	596	c.490G>A	c.(490-492)GTG>ATG	p.V164M	ZDHHC8_uc002zrr.1_Missense_Mutation_p.V164M|ZDHHC8_uc010gsa.2_Intron	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	164	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					GGTGGGCGTCGTGGCCTTCGG	0.602		NA											8	60					0	0	0	0
PIK3IP1	113791	broad.mit.edu	37	22	31688261	31688261	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:31688261C>T	uc003akm.2	-	1	260	c.70G>A	c.(70-72)GGC>AGC	p.G24S	PIK3IP1_uc003akl.2_5'Flank|PIK3IP1_uc011alo.1_Missense_Mutation_p.G24S|PIK3IP1_uc003akn.2_Silent_p.E4E|PIK3IP1_uc003ako.2_Missense_Mutation_p.G24S	NM_052880	NP_443112	Q96FE7	P3IP1_HUMAN	HGFL protein isoform 1	24	Extracellular (Potential).|Kringle.					integral to membrane				ovary(1)	1						GTAATCTCACCTCCAGATCCA	0.502		NA									OREG0026478	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	56					0	0	0	0
C22orf42	150297	broad.mit.edu	37	22	32545757	32545757	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:32545757C>T	uc003amd.2	-	8	706	c.665G>A	c.(664-666)AGA>AAA	p.R222K		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	222										ovary(1)|skin(1)	2						ATCTTCATATCTCTCCTTTGC	0.279		NA											9	48					0	0	0	0
SELO	83642	broad.mit.edu	37	22	50654274	50654274	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr22:50654274T>C	uc011arr.1	+	6	1538	c.1480T>C	c.(1480-1482)TTC>CTC	p.F494L	SELO_uc010hap.2_Missense_Mutation_p.F305L|SELO_uc003bjy.2_Missense_Mutation_p.F174L|SELO_uc003bjz.2_Missense_Mutation_p.L246P	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	494											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GAGGCTGGCCTTCCGGCCCCA	0.582		NA											19	58					0	0	0	0
CSPG5	10675	broad.mit.edu	37	3	47618893	47618893	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:47618893A>T	uc003crp.3	-	2	799	c.623T>A	c.(622-624)ATT>AAT	p.I208N	CSPG5_uc003crn.2_Missense_Mutation_p.I70N|CSPG5_uc003cro.3_Missense_Mutation_p.I208N|CSPG5_uc011bbb.1_Missense_Mutation_p.I70N	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	208	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GTCGATGTCAATGATATCTGA	0.587		NA											13	24					0	0	0	0
MST1R	4486	broad.mit.edu	37	3	49933239	49933239	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:49933239C>T	uc003cxy.3	-	12	3135	c.2871G>A	c.(2869-2871)ACG>ACA	p.T957T	MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	957	Extracellular (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TACCAAGGAGCGTGCTCTGTG	0.607		NA											6	46					0	0	0	0
PHLDB2	90102	broad.mit.edu	37	3	111686631	111686631	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:111686631T>A	uc010hqa.2	+	15	3686	c.3275T>A	c.(3274-3276)ATA>AAA	p.I1092K	PHLDB2_uc003dyc.2_Missense_Mutation_p.I1076K|PHLDB2_uc003dyd.2_Missense_Mutation_p.I1049K|PHLDB2_uc003dyg.2_Missense_Mutation_p.I1092K|PHLDB2_uc003dyh.2_Missense_Mutation_p.I1049K|PHLDB2_uc003dyi.2_Missense_Mutation_p.I583K|PHLDB2_uc003dyj.2_Missense_Mutation_p.I147K	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1092	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						CAGAAGTTAATAGAAAAGGAA	0.468		NA									OREG0015707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	29					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126752808	126752808	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:126752808G>A	uc003ejg.2	+	31	5574	c.5570G>A	c.(5569-5571)CGG>CAG	p.R1857Q	PLXNA1_uc003ejh.2_Missense_Mutation_p.R525Q	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1880	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CGGCGGCAGCGGCTGCGGAGC	0.652		NA											4	16					0	0	0	0
ZNF595	152687	broad.mit.edu	37	4	86195	86195	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:86195G>C	uc003fzv.1	+	6	957	c.801G>C	c.(799-801)AGG>AGC	p.R267S	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.R35S|ZNF595_uc011but.1_Missense_Mutation_p.R35S	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	267					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		CCTTTACAAGGTCCACAACAC	0.408		NA											40	21					0	0	0	0
TACC3	10460	broad.mit.edu	37	4	1746264	1746264	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:1746264A>G	uc003gdo.2	+	14	2351	c.2243A>G	c.(2242-2244)AAG>AGG	p.K748R	TACC3_uc003gdp.2_Missense_Mutation_p.K388R|TACC3_uc010ica.2_Missense_Mutation_p.K169R	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	748	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			TCACTGAAGAAGTGCGTGGAG	0.612		NA											41	21					0	0	0	0
RBPJ	3516	broad.mit.edu	37	4	26407892	26407892	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:26407892G>A	uc003grx.1	+	4	430	c.194G>A	c.(193-195)AGG>AAG	p.R65K	RBPJ_uc003gry.1_Missense_Mutation_p.R50K|RBPJ_uc003grz.1_Missense_Mutation_p.R65K|RBPJ_uc011bxt.1_Missense_Mutation_p.R65K|RBPJ_uc003gsa.1_Missense_Mutation_p.R51K|RBPJ_uc003gsb.1_Missense_Mutation_p.R52K|RBPJ_uc003gsc.1_Missense_Mutation_p.R51K	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	65					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				AATGAAAAAAGGTAAGATTAT	0.333		NA											56	37					0	0	0	0
UGT2B11	10720	broad.mit.edu	37	4	70080272	70080272	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:70080272C>G	uc003heh.2	-	1	178	c.169G>C	c.(169-171)GCA>CCA	p.A57P	uc003hei.1_RNA	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	57					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GCTGAAGATGCCAGTACAGTC	0.393		NA											17	214					0	0	0	0
RXFP1	59350	broad.mit.edu	37	4	159573014	159573014	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:159573014G>A	uc003ipz.2	+	18	2163	c.2081G>A	c.(2080-2082)CGG>CAG	p.R694Q	RXFP1_uc011cja.1_Missense_Mutation_p.R589Q|RXFP1_uc010iqo.2_Missense_Mutation_p.R646Q|RXFP1_uc011cjb.1_Missense_Mutation_p.R592Q|RXFP1_uc010iqk.2_Missense_Mutation_p.R562Q|RXFP1_uc011cjc.1_Missense_Mutation_p.R613Q|RXFP1_uc011cjd.1_Missense_Mutation_p.R613Q|RXFP1_uc010iql.2_Missense_Mutation_p.R538Q|RXFP1_uc011cje.1_Missense_Mutation_p.R721Q|RXFP1_uc010iqm.2_Missense_Mutation_p.R661Q|RXFP1_uc011cjf.1_Missense_Mutation_p.R563Q|RXFP1_uc010iqn.2_Missense_Mutation_p.R639Q	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	694	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ATGATTCATCGGTTTTGGTAT	0.393		NA											21	54					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187540845	187540845	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:187540845C>A	uc003izf.2	-	10	7083	c.6895G>T	c.(6895-6897)GGA>TGA	p.G2299*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2299	Extracellular (Potential).|Cadherin 21.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACAGACGTTCCAATTACAGAT	0.433		NA								HNSCC(5;0.00058)			82	54					1.16e-35	3.36e-35	1	0
DNAH5	1767	broad.mit.edu	37	5	13817734	13817734	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr5:13817734C>T	uc003jfd.2	-	42	6953	c.6911G>A	c.(6910-6912)CGG>CAG	p.R2304Q		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2304	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AACGTCCAGCCGACCAAACAT	0.403		NA							Kartagener_syndrome				27	48					0	0	0	0
MYO10	4651	broad.mit.edu	37	5	16682073	16682073	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr5:16682073C>T	uc003jft.3	-	31	4564	c.4096G>A	c.(4096-4098)GCC>ACC	p.A1366T	MYO10_uc011cnb.1_5'UTR|MYO10_uc011cnc.1_Missense_Mutation_p.A245T|MYO10_uc011cnd.1_Missense_Mutation_p.A723T|MYO10_uc011cne.1_Missense_Mutation_p.A723T|MYO10_uc010itx.2_Missense_Mutation_p.A988T	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1366					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						GGCGTGTCGGCGTTGCAGTGC	0.577		NA											22	110					0	0	0	0
MCCC2	64087	broad.mit.edu	37	5	70927976	70927976	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr5:70927976C>T	uc003kbs.3	+	8	905	c.767C>T	c.(766-768)TCT>TTT	p.S256F	MCCC2_uc010iyv.1_Missense_Mutation_p.S256F|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Missense_Mutation_p.S125F	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	256	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GAAGAAGTATCTGCTGAGGAT	0.398		NA											18	70					0	0	0	0
PRPF4B	8899	broad.mit.edu	37	6	4052307	4052307	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:4052307G>A	uc003mvv.2	+	10	2382	c.2291G>A	c.(2290-2292)TGT>TAT	p.C764Y	PRPF4B_uc003mvw.2_RNA|C6orf146_uc010jnq.1_Intron|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	764	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CAGCATCTTTGTCTGGTATTC	0.353		NA											20	38					0	0	0	0
HIST1H4B	8366	broad.mit.edu	37	6	26027417	26027417	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:26027417C>T	uc003nfr.2	-	1	64	c.64G>A	c.(64-66)GTG>ATG	p.V22M		NM_003544	NP_003535	P62805	H4_HUMAN	histone cluster 1, H4b	22					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TCCCGCAGCACTTTTCGGTGA	0.532		NA											10	64					0	0	0	0
HIST1H3I	8354	broad.mit.edu	37	6	27839984	27839984	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:27839984T>A	uc003njy.2	-	1	116	c.110A>T	c.(109-111)AAG>ATG	p.K37M		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GTGGGGCTTCTTGACGCCACC	0.672		NA											16	68					0	0	0	0
MAPK13	5603	broad.mit.edu	37	6	36106785	36106785	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:36106785T>C	uc003ols.2	+	11	1069	c.971T>C	c.(970-972)TTT>TCT	p.F324S	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	324					cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						CAGCAGCCGTTTGATGATTCC	0.602		NA											15	39					0	0	0	0
NR2E1	7101	broad.mit.edu	37	6	108502785	108502785	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:108502785C>T	uc003psg.2	+	8	1680	c.925C>T	c.(925-927)CGG>TGG	p.R309W		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	309	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		GAGAAGTTTCCGGAATGCTGC	0.438		NA											16	60					0	0	0	0
PDE10A	10846	broad.mit.edu	37	6	165806230	165806230	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr6:165806230G>A	uc003qun.2	-	17	1772	c.1531C>T	c.(1531-1533)CGG>TGG	p.R511W	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.R441W|PDE10A_uc003quo.2_Missense_Mutation_p.R521W	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	511					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TAAGGAACCCGCCGATAGTTC	0.428		NA											6	41					0	0	0	0
ZFAND2A	90637	broad.mit.edu	37	7	1197817	1197817	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:1197817G>A	uc003skc.2	-	2	333	c.32C>T	c.(31-33)TCA>TTA	p.S11L	ZFAND2A_uc003skd.3_Missense_Mutation_p.S11L|uc003skf.1_5'Flank	NM_182491	NP_872297	Q8N6M9	ZFN2A_HUMAN	zinc finger, AN1-type domain 2A	11	AN1-type 1.					cytoplasm|nucleus	zinc ion binding			ovary(1)	1		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.82e-15)		AGTCTTTTCTGAACAATGCTT	0.398		NA											8	398					0	0	0	0
ZNF12	7559	broad.mit.edu	37	7	6731206	6731206	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:6731206T>C	uc003sqt.1	-	5	1921	c.1367A>G	c.(1366-1368)TAT>TGT	p.Y456C	ZNF12_uc011jxa.1_Missense_Mutation_p.Y294C|ZNF12_uc003sqs.1_Missense_Mutation_p.Y418C	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	456	C2H2-type 7.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		ATGAGTTCTATAATGTACAGT	0.433		NA											17	49					0	0	0	0
HOXA11	3207	broad.mit.edu	37	7	27224479	27224479	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:27224479C>A	uc003syx.2	-	1	357	c.285G>T	c.(283-285)CAG>CAT	p.Q95H	HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	95					branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						CGCTGGGCGCCTGCAGGCAGT	0.657		NA	T	NUP98	CML								15	54					6.72e-11	1.9e-10	1	0
PCLO	27445	broad.mit.edu	37	7	82585666	82585666	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:82585666A>G	uc003uhx.2	-	5	4892	c.4603T>C	c.(4603-4605)TCA>CCA	p.S1535P	PCLO_uc003uhv.2_Missense_Mutation_p.S1535P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1466					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGCTTGATGAGCCAACACTA	0.403		NA											6	83					0	0	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964789	88964789	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:88964789C>T	uc011khi.1	+	4	3031	c.2493C>T	c.(2491-2493)AAC>AAT	p.N831N		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	831						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTGATTCTAACTCACAGATTT	0.373		NA								HNSCC(36;0.09)			14	43					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100678303	100678303	+	Silent	SNP	A	A	C	rs140408252		TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:100678303A>C	uc003uxp.1	+	3	3659	c.3606A>C	c.(3604-3606)CCA>CCC	p.P1202P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1202	Extracellular (Potential).|Ser-rich.|18.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCTCCTCCAACTGCTGAAG	0.522		NA											56	613					0	0	0	0
FBXL13	222235	broad.mit.edu	37	7	102453908	102453908	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:102453908A>G	uc003vaq.2	-	20	2516	c.2089T>C	c.(2089-2091)TTT>CTT	p.F697L	FBXL13_uc010liq.1_Missense_Mutation_p.F230L|FBXL13_uc010lir.1_Missense_Mutation_p.F652L|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.F669L|FAM185A_uc011klh.1_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	697											0						TCATAGCCAAACCAACGTGGA	0.408		NA											12	117					0	0	0	0
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	A	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507		NA											11	26					0	0	0	0
ABP1	26	broad.mit.edu	37	7	150556008	150556008	+	Silent	SNP	C	C	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:150556008C>T	uc003why.1	+	4	5946	c.1728C>T	c.(1726-1728)TAC>TAT	p.Y576Y	ABP1_uc003whz.1_Silent_p.Y576Y|ABP1_uc003wia.1_Silent_p.Y576Y	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	576					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	TGCCTAAGTACCTGCTCTTTA	0.652		NA											5	36					0	0	0	0
DPP6	1804	broad.mit.edu	37	7	154172049	154172049	+	Missense_Mutation	SNP	G	G	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:154172049G>T	uc003wlk.2	+	3	513	c.384G>T	c.(382-384)AAG>AAT	p.K128N	DPP6_uc003wli.2_Missense_Mutation_p.K64N|DPP6_uc003wlj.2_Missense_Mutation_p.K128N|DPP6_uc010lqh.1_Missense_Mutation_p.K66N|DPP6_uc003wlm.2_Missense_Mutation_p.K66N|DPP6_uc011kvq.1_Missense_Mutation_p.K66N	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	128	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGTCTCAAAAGAAGAAGGTCA	0.378		NA											17	48					3.99e-14	1.14e-13	1	0
DPP6	1804	broad.mit.edu	37	7	154561189	154561189	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr7:154561189G>A	uc003wlk.2	+	9	1075	c.946G>A	c.(946-948)GCC>ACC	p.A316T	DPP6_uc003wli.2_Missense_Mutation_p.A252T|DPP6_uc003wlm.2_Missense_Mutation_p.A254T|DPP6_uc011kvq.1_Missense_Mutation_p.A209T	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	316	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			ACTCGCCTACGCCGCCATCAA	0.522		NA											12	65					0	0	0	0
IDO1	3620	broad.mit.edu	37	8	39775722	39775722	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:39775722G>A	uc003xnm.2	+	3	413	c.299G>A	c.(298-300)CGT>CAT	p.R100H	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	100					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	GGAGATGTCCGTAAGGTTTGG	0.393		NA											16	80					0	0	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70674022	70674022	+	Silent	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:70674022A>G	uc003xyl.2	-	3	1703	c.996T>C	c.(994-996)AAT>AAC	p.N332N	SLCO5A1_uc010lzb.2_Silent_p.N332N|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Silent_p.N332N|SLCO5A1_uc010lzc.2_Silent_p.N332N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	332	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGTGAACAGGATTTCTGGGAT	0.378		NA											4	55					0	0	0	0
SNTB1	6641	broad.mit.edu	37	8	121706116	121706116	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:121706116T>C	uc010mdg.2	-	2	830	c.604A>G	c.(604-606)AAG>GAG	p.K202E	SNTB1_uc003ype.2_Missense_Mutation_p.K202E	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	202	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GATCCTTTCTTCACATAGGGC	0.517		NA											21	86					0	0	0	0
LRRC6	23639	broad.mit.edu	37	8	133596002	133596002	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr8:133596002G>A	uc003ytk.2	-	11	1239	c.1165C>T	c.(1165-1167)CAG>TAG	p.Q389*	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	389	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AATGCTCGCTGACCACCTGTG	0.378		NA											33	42					0	0	0	0
NFX1	4799	broad.mit.edu	37	9	33294473	33294473	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:33294473T>A	uc003zsq.2	+	2	142	c.81T>A	c.(79-81)AAT>AAA	p.N27K	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Missense_Mutation_p.N27K|NFX1_uc003zso.2_Missense_Mutation_p.N27K|NFX1_uc003zsp.1_Missense_Mutation_p.N27K|NFX1_uc010mjr.1_Missense_Mutation_p.N27K|NFX1_uc003zsr.2_Missense_Mutation_p.N27K	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	27					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		AGAAAAAAAATTCTGGTCTAA	0.383		NA											84	104					0	0	0	0
VPS13A	23230	broad.mit.edu	37	9	79955422	79955422	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:79955422G>A	uc004akr.2	+	50	7242	c.6982G>A	c.(6982-6984)GCT>ACT	p.A2328T	VPS13A_uc004akp.3_Missense_Mutation_p.A2328T|VPS13A_uc004akq.3_Missense_Mutation_p.A2328T|VPS13A_uc004aks.2_Missense_Mutation_p.A2289T	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2328					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TATATCAGTGGCTGAAGAAGG	0.338		NA											17	56					0	0	0	0
OR1L8	138881	broad.mit.edu	37	9	125330736	125330736	+	Silent	SNP	G	G	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:125330736G>T	uc004bmp.1	-	1	21	c.21C>A	c.(19-21)ACC>ACA	p.T7T		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						AGACACTGCTGGTGTGGTTGA	0.448		NA											7	54					2.74e-10	7.72e-10	1	0
ODF2	4957	broad.mit.edu	37	9	131247076	131247076	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:131247076A>T	uc011mbd.1	+	12	1512	c.1201A>T	c.(1201-1203)AGC>TGC	p.S401C	ODF2_uc011maz.1_Missense_Mutation_p.S401C|ODF2_uc010myb.2_Missense_Mutation_p.S377C|ODF2_uc011mbb.1_Missense_Mutation_p.S335C|ODF2_uc011mbc.1_Missense_Mutation_p.S320C|ODF2_uc004bva.2_Missense_Mutation_p.S354C|ODF2_uc004bvb.2_Missense_Mutation_p.S377C|ODF2_uc011mbe.1_Missense_Mutation_p.S396C|ODF2_uc004bvc.2_Missense_Mutation_p.S377C|ODF2_uc010myc.2_Missense_Mutation_p.S344C|ODF2_uc011mbf.1_Missense_Mutation_p.S382C|ODF2_uc004bvd.3_Missense_Mutation_p.S401C|ODF2_uc004bve.2_Missense_Mutation_p.S382C|uc004bvg.2_5'Flank	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	401	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						AGACAAAGAGAGCTTGAAGAA	0.567		NA											5	16					0	0	0	0
SNAPC4	6621	broad.mit.edu	37	9	139273385	139273385	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr9:139273385G>A	uc004chh.2	-	21	2903	c.2894C>T	c.(2893-2895)ACT>ATT	p.T965I		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	965	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGAGCCAGAAGTGCCAGGTTT	0.667		NA											14	23					0	0	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839869	27839869	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chrX:27839869T>A	uc004dbw.2	+	3	673	c.446T>A	c.(445-447)TTC>TAC	p.F149Y		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	149	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						AAGAGCCAGTTCCCTGTAATC	0.438		NA											23	30					0	0	0	0
MED12	9968	broad.mit.edu	37	X	70350030	70350030	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chrX:70350030A>G	uc004dyy.2	+	28	4212	c.4013A>G	c.(4012-4014)AAC>AGC	p.N1338S	MED12_uc011mpq.1_Missense_Mutation_p.N1338S|MED12_uc004dyz.2_Missense_Mutation_p.N1338S|MED12_uc004dza.2_Missense_Mutation_p.N1185S|MED12_uc010nla.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1338					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GATGGGGAAAACCCCCAGCGG	0.577		NA											2	11					0	0	0	0
XKRX	402415	broad.mit.edu	37	X	100183281	100183281	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chrX:100183281A>G	uc004egn.2	-	1	618	c.13T>C	c.(13-15)TAT>CAT	p.Y5H	XKRX_uc011mre.1_5'UTR	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	5						integral to membrane|plasma membrane				breast(1)	1						GGAATTTCATAAACTCTGTCC	0.488		NA											72	65					0	0	0	0
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr12:121134166_121134168delGAA	uc001tyy.1	+	5	848_850	c.697_699delGAA	c.(697-699)GAAdel	p.E238del		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	238	Poly-Glu.|Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						gaaagaagaggaagaagaagaag	0.404		NA											7	158	---	---	---	---	NA	NA	NA	NA
CD300E	342510	broad.mit.edu	37	17	72608823	72608823	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr17:72608823delT	uc002jlb.1	-	4	628	c.587delA	c.(586-588)AACfs	p.N196fs		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	196	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CTGAGGCCTGTTCACCCAGAA	0.632		NA											26	98	---	---	---	---	NA	NA	NA	NA
C20orf118	140711	broad.mit.edu	37	20	35515884	35515884	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr20:35515884delT	uc002xgg.1	+	5	473	c.465delT	c.(463-465)TCTfs	p.S155fs		NM_080628	NP_542195	A0PJX2	CT118_HUMAN	hypothetical protein LOC140711	155	TLD.										0		Myeloproliferative disorder(115;0.00874)				GAAGCAACTCTTTCTTTGTGA	0.532		NA									OREG0025911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	112	---	---	---	---	NA	NA	NA	NA
SFRS15	57466	broad.mit.edu	37	21	33060638	33060639	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr21:33060638_33060639insA	uc002ypd.2	-	16	2450_2451	c.2024_2025insT	c.(2023-2025)ATAfs	p.I675fs	SFRS15_uc002ype.2_Frame_Shift_Ins_p.I675fs|SFRS15_uc010glu.2_Frame_Shift_Ins_p.I660fs|SFRS15_uc002ypf.1_Frame_Shift_Ins_p.I349fs	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	675						nucleus	nucleotide binding|RNA binding				0						GTGGCACTGTTATAGGTGCAGG	0.441		NA											38	118	---	---	---	---	NA	NA	NA	NA
BAP1	8314	broad.mit.edu	37	3	52439912	52439913	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr3:52439912_52439913delTG	uc003ddx.2	-	10	914_915	c.799_800delCA	c.(799-801)CAGfs	p.Q267fs	BAP1_uc003ddw.2_5'Flank|BAP1_uc010hmg.2_5'Flank|BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	267					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CAGCTCTGGCTGTGTTACTCTT	0.52		NA	N|Mis|F|S|O		uveal melanoma|breast|NSCLC								21	44	---	---	---	---	NA	NA	NA	NA
FBXW7	55294	broad.mit.edu	37	4	153251878	153251886	+	Splice_Site	DEL	AGTTACCTT	AGTTACCTT	-			TCGA-CV-7263-01A-11D-2012-08	TCGA-CV-7263-10A-01D-2013-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	19a07472-c8b9-4a34-b2cb-11ace35e7903	d34d6638-773d-4695-a34a-63d7f9685243	g.chr4:153251878_153251886delAGTTACCTT	uc003ims.2	-	7	1271	c.1122_splice	c.e7+1	p.K374_splice	FBXW7_uc011cii.1_Splice_Site_p.K374_splice|FBXW7_uc003imt.2_Splice_Site_p.K374_splice|FBXW7_uc011cih.1_Splice_Site_p.K198_splice|FBXW7_uc003imq.2_Splice_Site_p.K294_splice|FBXW7_uc003imr.2_Splice_Site_p.K256_splice	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform						interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGCAGAGTTCAGTTACCTTAGGAGATTTG	0.388		NA	Mis|N|D|F		colorectal|endometrial|T-ALL								43	56	---	---	---	---	NA	NA	NA	NA