Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PADI6	353238	broad.mit.edu	37	1	17727771	17727771	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:17727771G>A	uc001bak.1	+	17	1922	c.1922G>A	c.(1921-1923)TGC>TAC	p.C641Y		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	633					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AAGGGGACCTGCTGCCTGGAA	0.537		NA											4	38					0	0	0	0
KIAA0754	643314	broad.mit.edu	37	1	39878082	39878082	+	Silent	SNP	T	T	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:39878082T>C	uc009vvt.1	+	1	2907	c.2145T>C	c.(2143-2145)TGT>TGC	p.C715C	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	579											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAAAGTTTGTGATGAGGATG	0.423		NA											6	38					0	0	0	0
EVI5	7813	broad.mit.edu	37	1	93167729	93167729	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:93167729C>T	uc001dox.2	-	5	750	c.740G>A	c.(739-741)AGT>AAT	p.S247N	EVI5_uc010otf.1_Missense_Mutation_p.S247N	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	247	Dimerization.|Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Rab-GAP TBC.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		TATAAAAGCACTTCCTTGACA	0.308		NA											8	34					0	0	0	0
ABCA4	24	broad.mit.edu	37	1	94496611	94496611	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:94496611G>A	uc001dqh.2	-	28	4298	c.4194C>T	c.(4192-4194)GGC>GGT	p.G1398G		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1398	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGGGGTATTCGCCAAAAGGAG	0.512		NA											6	23					0	0	0	0
CSF1	1435	broad.mit.edu	37	1	110456910	110456910	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:110456910C>T	uc001dyu.2	+	2	482	c.69C>T	c.(67-69)GTC>GTT	p.V23V	CSF1_uc001dyt.2_Silent_p.V23V|CSF1_uc001dyv.3_Silent_p.V23V|CSF1_uc001dyw.3_Silent_p.V23V	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	23					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGTTGTTGGTCTGTCTCCTGG	0.587		NA											16	29					0	0	0	0
RSBN1	54665	broad.mit.edu	37	1	114354936	114354936	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:114354936C>T	uc001edq.2	-	1	135	c.99G>A	c.(97-99)GCG>GCA	p.A33A	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	33						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCCCCCGTCCGCGCATCGCG	0.672		NA											4	53					0	0	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527		NA											4	34					0	0	0	0
ANXA9	8416	broad.mit.edu	37	1	150967079	150967079	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:150967079G>A	uc001ewa.2	+	13	1349	c.879G>A	c.(877-879)CTG>CTA	p.L293L		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	293	Annexin 4.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACCAAGTCCTGATTCGCATCC	0.483		NA											12	149					0	0	0	0
FAM5C	339479	broad.mit.edu	37	1	190203579	190203579	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:190203579C>T	uc001gse.1	-	5	879	c.647G>A	c.(646-648)GGC>GAC	p.G216D	FAM5C_uc010pot.1_Missense_Mutation_p.G114D	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	216						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GTTACTGCAGCCAAGAGGACC	0.378		NA											9	51					0	0	0	0
KIF21B	23046	broad.mit.edu	37	1	200946364	200946364	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:200946364G>A	uc001gvs.1	-	31	4618	c.4301C>T	c.(4300-4302)GCC>GTC	p.A1434V	KIF21B_uc001gvr.1_Missense_Mutation_p.A1421V|KIF21B_uc009wzl.1_Missense_Mutation_p.A1434V|KIF21B_uc010ppn.1_Missense_Mutation_p.A1421V	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1434	WD 3.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GATGCGGACGGCATTGCCCGA	0.632		NA											4	98					0	0	0	0
CR1	1378	broad.mit.edu	37	1	207793408	207793408	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:207793408C>G	uc001hfy.2	+	35	6040	c.5900C>G	c.(5899-5901)TCT>TGT	p.S1967C	CR1_uc001hfx.2_Missense_Mutation_p.S2417C	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1967	Sushi 30.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						AAATGTACCTCTCGTAAGTGC	0.493		NA									OREG0014194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	14					0	0	0	0
CABC1	56997	broad.mit.edu	37	1	227169739	227169739	+	Missense_Mutation	SNP	G	G	A	rs148376283		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:227169739G>A	uc001hqm.1	+	11	4161	c.742G>A	c.(742-744)GTG>ATG	p.V248M	CABC1_uc001hqn.1_Missense_Mutation_p.V248M|CABC1_uc009xeq.1_Missense_Mutation_p.V196M|CABC1_uc010pvq.1_Translation_Start_Site|CABC1_uc010pvr.1_Translation_Start_Site|CABC1_uc001hqo.1_Translation_Start_Site|CABC1_uc009xer.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	248					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				GAAGAAGGCCGTGCTGGGTTC	0.652		NA											29	36					0	0	0	0
NID1	4811	broad.mit.edu	37	1	236180536	236180536	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:236180536C>T	uc001hxo.2	-	10	2268	c.2166G>A	c.(2164-2166)GGG>GGA	p.G722G	NID1_uc009xgd.2_Intron	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	722	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TTGTGTGGCTCCCACACACTG	0.433		NA											18	93					0	0	0	0
CHRM3	1131	broad.mit.edu	37	1	240071198	240071198	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:240071198C>A	uc001hyp.2	+	5	1226	c.447C>A	c.(445-447)TAC>TAA	p.Y149*		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	149	Helical; Name=3; (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CCATTGACTACGTAGCCAGCA	0.473		NA											27	34					9.86e-18	1.15e-17	1	0
FMN2	56776	broad.mit.edu	37	1	240492666	240492666	+	Silent	SNP	C	C	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:240492666C>A	uc010pyd.1	+	10	4560	c.4335C>A	c.(4333-4335)CCC>CCA	p.P1445P	FMN2_uc010pye.1_Silent_p.P1449P|FMN2_uc010pyf.1_Silent_p.P91P|FMN2_uc010pyg.1_Silent_p.P41P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1445	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CACTAATCCCCAACTTTTCAG	0.363		NA											11	87					0.000673444	0.000717068	1	0
UPF2	26019	broad.mit.edu	37	10	11973704	11973704	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr10:11973704C>G	uc001ila.2	-	19	4098	c.3624G>C	c.(3622-3624)GAG>GAC	p.E1208D	UPF2_uc001ilb.2_Missense_Mutation_p.E1208D|UPF2_uc001ilc.2_Missense_Mutation_p.E1208D	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	1208	Sufficient for interaction with UPF1 C- terminus.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TTCTCATCCTCTCTTCTTGTT	0.373		NA											10	58					0	0	0	0
CHST15	51363	broad.mit.edu	37	10	125804104	125804104	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr10:125804104T>C	uc001lhl.2	-	2	1391	c.878A>G	c.(877-879)AAG>AGG	p.K293R	CHST15_uc001lhm.2_Missense_Mutation_p.K293R|CHST15_uc001lhn.2_Missense_Mutation_p.K293R|CHST15_uc010que.1_Missense_Mutation_p.K293R|CHST15_uc001lho.2_Missense_Mutation_p.K293R	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	293	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						ACCAAAGCGCTTCCGGGTCCA	0.637		NA											7	12					0	0	0	0
PHLDA2	7262	broad.mit.edu	37	11	2950579	2950579	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:2950579C>T	uc001lxa.1	-	1	72	c.16G>A	c.(16-18)GAG>AAG	p.E6K		NM_003311	NP_003302	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain family A member	6					apoptosis	cytoplasm|membrane					0		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CGTAGCACCTCGTCGGGGGAT	0.677		NA											10	8					0	0	0	0
HPX	3263	broad.mit.edu	37	11	6452604	6452604	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:6452604A>G	uc001mdg.2	-	10	1287	c.1226T>C	c.(1225-1227)ATG>ACG	p.M409T	HPX_uc001mdf.2_Missense_Mutation_p.M155T|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	409					cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GGACTTTTCCATACACAAGGC	0.562		NA											15	34					0	0	0	0
TUB	7275	broad.mit.edu	37	11	8123160	8123160	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:8123160C>T	uc001mga.2	+	12	1664	c.1515C>T	c.(1513-1515)TGC>TGT	p.C505C	TUB_uc010rbk.1_Silent_p.C511C|TUB_uc001mfy.2_Silent_p.C560C	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	505					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGCTGGCGTGCGAGTAGAGGC	0.597		NA											15	8					0	0	0	0
MS4A14	84689	broad.mit.edu	37	11	60170536	60170536	+	Splice_Site	SNP	T	T	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:60170536T>C	uc001npj.2	+	4	1033	c.468_splice	c.e4+2	p.I156_splice	MS4A14_uc001npi.2_Splice_Site_p.I44_splice|MS4A14_uc001npn.2_Splice_Site|MS4A14_uc001npk.2_Splice_Site_p.I139_splice|MS4A14_uc001npl.2_Splice_Site|MS4A14_uc001npm.2_Splice_Site	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity			breast(1)	1						CTTTTCATTGTAAGTGGTCTT	0.343		NA											21	57					0	0	0	0
MTA2	9219	broad.mit.edu	37	11	62361790	62361790	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:62361790C>G	uc001ntq.1	-	17	2163	c.1782G>C	c.(1780-1782)CAG>CAC	p.Q594H	TUT1_uc001nto.2_5'Flank|MTA2_uc010rlx.1_Missense_Mutation_p.Q421H	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	594					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTTTAGTTTCTGACGCTTGG	0.567		NA											8	49					0	0	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67172899	67172899	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:67172899G>A	uc001ola.2	+	4	311	c.282G>A	c.(280-282)CCG>CCA	p.P94P	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_Silent_p.P94P|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	94	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AAGGCATCCCGTCTGCCCTGC	0.657		NA											13	38					0	0	0	0
TPCN2	219931	broad.mit.edu	37	11	68822187	68822187	+	Splice_Site	SNP	A	A	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:68822187A>G	uc001oos.2	+	3	291	c.175_splice	c.e3-2	p.Y59_splice	TPCN2_uc009ysk.1_Splice_Site|TPCN2_uc001oor.2_Intron|TPCN2_uc010rqg.1_Splice_Site_p.Y59_splice	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2						cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTTCGCTTGTAGTACCGCTCC	0.577		NA											6	25					0	0	0	0
NFRKB	4798	broad.mit.edu	37	11	129748208	129748208	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:129748208G>A	uc001qfi.2	-	15	1708	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W	NFRKB_uc001qfg.2_Missense_Mutation_p.R528W|NFRKB_uc001qfh.2_Missense_Mutation_p.R526W|NFRKB_uc010sbw.1_Silent_p.L513L	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	503					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		ACTCACACCCGAGGGACAGGT	0.433		NA											19	20					0	0	0	0
PUS7L	83448	broad.mit.edu	37	12	44130374	44130374	+	Missense_Mutation	SNP	T	T	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr12:44130374T>A	uc001rnq.3	-	7	2024	c.1535A>T	c.(1534-1536)GAG>GTG	p.E512V	PUS7L_uc001rnr.3_Missense_Mutation_p.E512V|PUS7L_uc001rns.3_Missense_Mutation_p.E512V|PUS7L_uc009zkb.2_Missense_Mutation_p.E199V	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	512	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		ACAACCTTCCTCGGTCATGCC	0.448		NA											12	50					0	0	0	0
PUS7L	83448	broad.mit.edu	37	12	44148848	44148848	+	Silent	SNP	A	A	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr12:44148848A>G	uc001rnq.3	-	2	690	c.201T>C	c.(199-201)TTT>TTC	p.F67F	PUS7L_uc001rnr.3_Silent_p.F67F|PUS7L_uc001rns.3_Silent_p.F67F|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	67					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		GTTTTTTGGGAAAATTATTTG	0.323		NA											4	52					0	0	0	0
EIF4B	1975	broad.mit.edu	37	12	53410391	53410391	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr12:53410391G>C	uc001sbh.3	+	2	354	c.148G>C	c.(148-150)GAT>CAT	p.D50H	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Missense_Mutation_p.D50H|EIF4B_uc010snv.1_Missense_Mutation_p.D50H|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	50					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						CCTGGAAGGAGATGGTAACTT	0.403		NA											11	52					0	0	0	0
VPS36	51028	broad.mit.edu	37	13	53007799	53007799	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr13:53007799C>T	uc001vgs.2	-	6	560	c.526G>A	c.(526-528)GAG>AAG	p.E176K	VPS36_uc001vgq.2_Missense_Mutation_p.E118K	NM_016075	NP_057159	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36	176	Potential.				cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			skin(1)	1		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		ACAGTTACCTCAGAAATGTTT	0.343		NA											3	41					0	0	0	0
CMTM5	116173	broad.mit.edu	37	14	23847950	23847950	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr14:23847950C>T	uc010akm.2	+	3	796	c.352C>T	c.(352-354)CAG>TAG	p.Q118*	CMTM5_uc001wjs.2_Intron|CMTM5_uc001wjt.2_Intron|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	118	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GGTCCAGCCCCAGCCCTGGCC	0.627		NA											5	18					0	0	0	0
TGM5	9333	broad.mit.edu	37	15	43545012	43545012	+	Silent	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:43545012G>C	uc001zrd.1	-	6	815	c.807C>G	c.(805-807)GGC>GGG	p.G269G	TGM5_uc001zre.1_Silent_p.G187G	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	269					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CGGGCTGGCAGCCTGTGGCGT	0.592		NA											11	51					0	0	0	0
CGNL1	84952	broad.mit.edu	37	15	57730854	57730854	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:57730854C>T	uc002aeg.2	+	2	733	c.657C>T	c.(655-657)TGC>TGT	p.C219C	CGNL1_uc010bfw.2_Silent_p.C219C	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	219	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TTCGTTTATGCAGCTCCGTGG	0.527		NA											18	128					0	0	0	0
FAM63B	54629	broad.mit.edu	37	15	59064131	59064131	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:59064131C>T	uc002afj.2	+	1	739	c.537C>T	c.(535-537)TTC>TTT	p.F179F	FAM63B_uc002afi.2_Silent_p.F179F|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	179										central_nervous_system(1)	1						TGGAGTCGTTCTCTAACCTGC	0.647		NA											11	19					0	0	0	0
CORO2B	10391	broad.mit.edu	37	15	69003203	69003203	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:69003203G>A	uc002arj.3	+	4	495	c.466G>A	c.(466-468)GCT>ACT	p.A156T	CORO2B_uc010bic.2_Missense_Mutation_p.A151T|CORO2B_uc002ark.2_5'Flank	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	156	WD 2.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						CCTGTTCAGCGCTGGCTACGA	0.622		NA											3	5					0	0	0	0
ISLR2	57611	broad.mit.edu	37	15	74426761	74426761	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:74426761C>T	uc002axd.2	+	4	2435	c.1666C>T	c.(1666-1668)CGC>TGC	p.R556C	ISLR2_uc002axe.2_Missense_Mutation_p.R556C|ISLR2_uc010bjg.2_Missense_Mutation_p.R556C|ISLR2_uc010bjf.2_Missense_Mutation_p.R556C	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	556	Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CTACTGGTTCCGCGGCCTGCG	0.637		NA											4	9					0	0	0	0
UBL7	84993	broad.mit.edu	37	15	74740855	74740855	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr15:74740855C>T	uc002axw.1	-	10	1131	c.969G>A	c.(967-969)CAG>CAA	p.Q323Q	UBL7_uc002axx.1_Silent_p.Q363Q|UBL7_uc010bjr.1_Silent_p.Q214Q|UBL7_uc002axy.1_Silent_p.Q323Q|UBL7_uc002axz.1_Silent_p.Q323Q	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	323							protein binding			ovary(1)	1						GAAGGGCATGCTGTAGGGCTT	0.542		NA											23	106					0	0	0	0
PKD1	5310	broad.mit.edu	37	16	2158547	2158547	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr16:2158547G>A	uc002cos.1	-	15	6830	c.6621C>T	c.(6619-6621)CCC>CCT	p.P2207P	PKD1_uc002cot.1_Silent_p.P2207P	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2207	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CGTCCACGCCGGGCAGGGCCA	0.697		NA											4	11					0	0	0	0
MVP	9961	broad.mit.edu	37	16	29851704	29851704	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr16:29851704A>G	uc002dui.2	+	8	1199	c.1115A>G	c.(1114-1116)GAG>GGG	p.E372G	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.E372G|MVP_uc010vea.1_5'UTR	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	372	MVP 7.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GCCAAAGTGGAGGTGGTGGAG	0.612		NA											2	8					0	0	0	0
ZNF423	23090	broad.mit.edu	37	16	49672378	49672378	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr16:49672378G>A	uc002efs.2	-	5	983	c.685C>T	c.(685-687)CGC>TGC	p.R229C	ZNF423_uc010vgn.1_Missense_Mutation_p.R112C	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	229	C2H2-type 5.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GAGAAGCCGCGCTTGCACACA	0.597		NA											6	46					0	0	0	0
ZNF516	9658	broad.mit.edu	37	18	74154962	74154962	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr18:74154962G>A	uc010dqx.1	-	2	284	c.49C>T	c.(49-51)CCC>TCC	p.P17S	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GCCCTGGTGGGGCTGGGGCCT	0.692		NA											7	4					0	0	0	0
CNN1	1264	broad.mit.edu	37	19	11651894	11651894	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:11651894G>A	uc002msc.1	+	2	231	c.67G>A	c.(67-69)GCC>ACC	p.A23T	CNN1_uc010xmb.1_5'UTR|CNN1_uc010xmc.1_5'UTR	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	23					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						GCCCCAGCTGGCCCAGAAGTA	0.632		NA											3	14					0	0	0	0
MAST1	22983	broad.mit.edu	37	19	12951871	12951871	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:12951871C>T	uc002mvm.2	+	3	367	c.239C>T	c.(238-240)TCC>TTC	p.S80F	MAST1_uc002mvk.2_Missense_Mutation_p.S76F|MAST1_uc002mvl.2_Missense_Mutation_p.S80F	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	80					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						TCGTTTGCCTCCTCCCGAAGG	0.627		NA											4	38					0	0	0	0
EMR3	84658	broad.mit.edu	37	19	14752358	14752358	+	Missense_Mutation	SNP	G	G	T	rs146538980	by1000genomes	TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:14752358G>T	uc002mzi.3	-	10	1269	c.1121C>A	c.(1120-1122)GCG>GAG	p.A374E	EMR3_uc010dzp.2_Missense_Mutation_p.A322E|EMR3_uc010xnv.1_Missense_Mutation_p.A248E	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	374	Helical; Name=1; (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						AGTGAGGGCCGCCAGGAGGAG	0.582		NA											8	37					2.18e-05	2.41e-05	1	0
HAUS8	93323	broad.mit.edu	37	19	17163638	17163638	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:17163638C>T	uc002nfe.2	-	10	1037	c.926G>A	c.(925-927)CGA>CAA	p.R309Q	HAUS8_uc002nff.2_Missense_Mutation_p.R308Q|HAUS8_uc002nfg.1_Missense_Mutation_p.R248Q|HAUS8_uc002nfh.1_Missense_Mutation_p.R309Q	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	309					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						GAGGTACCTTCGGAGCTCAAG	0.527		NA									OREG0025339	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	80					0	0	0	0
SFRS16	11129	broad.mit.edu	37	19	45555410	45555410	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:45555410G>C	uc002pak.2	+	3	279	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Intron|SFRS16_uc002pam.2_Missense_Mutation_p.E61Q|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	61					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCTGGCCGCTGAGAGCCCTGT	0.562		NA											4	49					0	0	0	0
GPR4	2828	broad.mit.edu	37	19	46094975	46094975	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:46094975G>A	uc002pcm.2	-	2	1095	c.150C>T	c.(148-150)AAC>AAT	p.N50N	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	50	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		CGCCCAGCTCGTTGCGCTGTT	0.617		NA											18	46					0	0	0	0
LILRA1	11024	broad.mit.edu	37	19	55106360	55106360	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr19:55106360G>A	uc002qgh.1	+	4	483	c.301G>A	c.(301-303)GGT>AGT	p.G101S	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.G101S	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	101	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTGTTTCTACGGTAGCCACAC	0.607		NA											11	52					0	0	0	0
TTC27	55622	broad.mit.edu	37	2	33012122	33012122	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:33012122A>G	uc002rom.2	+	16	2135	c.1904A>G	c.(1903-1905)TAC>TGC	p.Y635C	TTC27_uc010ymx.1_Missense_Mutation_p.Y585C|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	635	TPR 6.|HAT 2.						protein binding			central_nervous_system(1)	1						TGGGAAAACTACATCCTCACC	0.393		NA											11	50					0	0	0	0
NRXN1	9378	broad.mit.edu	37	2	50280443	50280443	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:50280443C>T	uc010fbp.2	-	4	1706	c.899G>A	c.(898-900)AGA>AAA	p.R300K	NRXN1_uc002rxb.3_Missense_Mutation_p.R1037K|NRXN1_uc010fbq.2_Missense_Mutation_p.R1405K|NRXN1_uc002rxe.3_Missense_Mutation_p.R1335K	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	300	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGGCTTTCCTCTTCTGGCTGT	0.453		NA											4	100					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	80646578	80646578	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:80646578G>A	uc010ysh.1	+	8	1147	c.1142G>A	c.(1141-1143)CGG>CAG	p.R381Q	CTNNA2_uc010yse.1_Missense_Mutation_p.R381Q|CTNNA2_uc010ysf.1_Missense_Mutation_p.R381Q|CTNNA2_uc010ysg.1_Missense_Mutation_p.R381Q|CTNNA2_uc010ysi.1_Missense_Mutation_p.R13Q	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	381					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CTGTAGCTTCGGAAAGCAGTG	0.358		NA											8	51					0	0	0	0
PSD4	23550	broad.mit.edu	37	2	113942946	113942946	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:113942946C>T	uc002tjc.2	+	4	1361	c.1178C>T	c.(1177-1179)TCT>TTT	p.S393F	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.S392F|PSD4_uc002tjf.2_5'UTR	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	393					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CAACAGGCCTCTCTCAGCCCT	0.413		NA											21	90					0	0	0	0
SCN2A	6326	broad.mit.edu	37	2	166152455	166152455	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:166152455G>A	uc002udc.2	+	2	412	c.122G>A	c.(121-123)CGC>CAC	p.R41H	SCN2A_uc002udd.2_Missense_Mutation_p.R41H|SCN2A_uc002ude.2_Missense_Mutation_p.R41H	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	41					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AAACAGGAACGCAAGGATGAG	0.473		NA											9	19					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179451387	179451387	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:179451387C>T	uc010zfg.1	-	257	56761	c.56537G>A	c.(56536-56538)CGC>CAC	p.R18846H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R12541H|TTN_uc010zfi.1_Missense_Mutation_p.R12474H|TTN_uc010zfj.1_Missense_Mutation_p.R12349H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19773							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGTCCAGCGATCTGCAGG	0.468		NA											26	73					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179606565	179606565	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr2:179606565C>T	uc010zfh.1	-	46	11106	c.10882G>A	c.(10882-10884)GAA>AAA	p.E3628K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E3561K|TTN_uc010zfj.1_Missense_Mutation_p.E3436K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3613							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E3436K(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACAAAAGTTCAAGTGTTTCA	0.373		NA											4	12					0	0	0	0
ISM1	140862	broad.mit.edu	37	20	13279972	13279972	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:13279972C>T	uc010gce.1	+	6	1267	c.1261C>T	c.(1261-1263)CTG>TTG	p.L421L	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	421	AMOP.					extracellular region					0						GGTGGACGTCCTGCCCTGGAT	0.622		NA											5	21					0	0	0	0
PCK1	5105	broad.mit.edu	37	20	56137828	56137828	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:56137828G>A	uc002xyn.3	+	4	646	c.483G>A	c.(481-483)ACG>ACA	p.T161T	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	161					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TCGAGCTGACGGATTCACCCT	0.612		NA											4	46					0	0	0	0
PRIC285	85441	broad.mit.edu	37	20	62192986	62192986	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:62192986G>A	uc002yfm.2	-	13	7696	c.6804C>T	c.(6802-6804)AGC>AGT	p.S2268S	PRIC285_uc002yfl.1_Silent_p.S1699S	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2268					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCTCCCGGGGGCTCTTCCTGA	0.657		NA											42	62					0	0	0	0
CECR5	27440	broad.mit.edu	37	22	17619607	17619607	+	Silent	SNP	C	C	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:17619607C>A	uc002zmf.2	-	7	796	c.768G>T	c.(766-768)CTG>CTT	p.L256L	CECR5_uc002zmd.2_Silent_p.L67L|CECR5_uc002zme.2_Silent_p.L48L|CECR5_uc002zmg.2_Intron|CECR5_uc002zmh.2_Silent_p.L226L	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	256							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				CCAGGCACAGCAGAAAGGTGC	0.537		NA											13	121					9.31e-06	1.04e-05	1	0
PISD	23761	broad.mit.edu	37	22	32017676	32017676	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:32017676G>A	uc003alm.3	-	4	524	c.517C>T	c.(517-519)CTG>TTG	p.L173L	PISD_uc003alk.2_Silent_p.L139L|PISD_uc003all.2_Silent_p.L138L|PISD_uc011alr.1_Silent_p.L138L|PISD_uc003aln.3_Silent_p.L173L	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	173					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	TGCGGCTTCAGCTTGCGCCGG	0.602		NA											5	29					0	0	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823814	38823814	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:38823814C>T	uc003avs.1	-	2	421	c.324G>A	c.(322-324)CCG>CCA	p.P108P	KCNJ4_uc003avt.1_Silent_p.P108P	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	108	Val/Gly/Ala/Pro stretch.|Extracellular (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					TGGGGGCCACCGGGGCTGCTC	0.577		NA											15	23					0	0	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41752804	41752804	+	Silent	SNP	C	C	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:41752804C>G	uc003azw.2	+	22	2889	c.2673C>G	c.(2671-2673)CTC>CTG	p.L891L	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	907	C3H1-type 4.				interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						AGTTCCGGCTCTGCGACAGGT	0.667		NA											7	39					0	0	0	0
FBLN1	2192	broad.mit.edu	37	22	45929029	45929029	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr22:45929029G>C	uc003bgj.1	+	6	778	c.631G>C	c.(631-633)GGT>CGT	p.G211R	FBLN1_uc003bgg.1_Missense_Mutation_p.G211R|FBLN1_uc003bgh.2_Missense_Mutation_p.G211R|FBLN1_uc010gzz.2_Missense_Mutation_p.G249R|FBLN1_uc003bgi.1_Missense_Mutation_p.G211R	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	211	EGF-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GCTGTCTGATGGTGTCTCCTG	0.637		NA											8	35					0	0	0	0
DPPA4	55211	broad.mit.edu	37	3	109049479	109049479	+	Missense_Mutation	SNP	T	T	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:109049479T>G	uc003dxq.3	-	5	626	c.571A>C	c.(571-573)ACA>CCA	p.T191P	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Missense_Mutation_p.T191P	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	191						nucleus	protein binding			upper_aerodigestive_tract(1)	1						ACCACAACTGTATTAACTCCC	0.562		NA											43	35					0	0	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113563487	113563487	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:113563487G>C	uc003eaq.3	+	2	241	c.165G>C	c.(163-165)TGG>TGC	p.W55C	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	55						integral to membrane				ovary(2)|skin(1)	3						GTGGTGACTGGAGCTTTTGGG	0.318		NA											11	68					0	0	0	0
SI	6476	broad.mit.edu	37	3	164725717	164725717	+	Missense_Mutation	SNP	A	A	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:164725717A>G	uc003fei.2	-	36	4311	c.4249T>C	c.(4249-4251)TAT>CAT	p.Y1417H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1417	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAAGGTGGATAATTTAGTTCG	0.239		NA								HNSCC(35;0.089)			8	75					0	0	0	0
TRA2B	6434	broad.mit.edu	37	3	185644425	185644425	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:185644425C>T	uc003fpv.2	-	2	410	c.134G>A	c.(133-135)CGT>CAT	p.R45H	TRA2B_uc003fpt.2_5'Flank|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_Intron|TRA2B_uc003fpw.2_Missense_Mutation_p.R45H	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	45	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						TGATCTGGAACGCCTGGAATC	0.488		NA											28	61					0	0	0	0
ATP8A1	10396	broad.mit.edu	37	4	42551058	42551058	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr4:42551058C>T	uc003gwr.2	-	19	1856	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K	ATP8A1_uc003gws.2_Missense_Mutation_p.E527K|ATP8A1_uc011byz.1_Missense_Mutation_p.E527K	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	542	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TTGAGCAATTCATATCTTTCT	0.308		NA											9	40					0	0	0	0
C5orf35	133383	broad.mit.edu	37	5	56207180	56207180	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:56207180C>A	uc003jqx.2	+	2	656	c.283C>A	c.(283-285)CAA>AAA	p.Q95K	C5orf35_uc003jqy.2_Intron	NM_153706	NP_714917	Q8NE22	CE035_HUMAN	hypothetical protein LOC133383	95										ovary(1)	1		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.173)		OV - Ovarian serous cystadenocarcinoma(10;2.58e-39)		AGTTGAACATCAAGGGGTGAA	0.363		NA											22	20					3.1e-05	3.42e-05	1	0
MAP1B	4131	broad.mit.edu	37	5	71491407	71491407	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:71491407C>T	uc003kbw.3	+	5	2466	c.2225C>T	c.(2224-2226)TCA>TTA	p.S742L	MAP1B_uc010iyw.1_Missense_Mutation_p.S759L|MAP1B_uc010iyx.1_Missense_Mutation_p.S616L|MAP1B_uc010iyy.1_Missense_Mutation_p.S616L	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	742	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GCAAAGAAATCATCTACTCCT	0.269		NA											8	77					0	0	0	0
ERAP1	51752	broad.mit.edu	37	5	96121595	96121595	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:96121595C>T	uc003kmm.2	-	13	2187	c.1840G>A	c.(1840-1842)GAT>AAT	p.D614N	ERAP1_uc003kml.2_Missense_Mutation_p.D614N|ERAP1_uc010jbm.1_Missense_Mutation_p.D426N|ERAP1_uc003kmn.2_Missense_Mutation_p.D614N	NM_001040458	NP_001035548	Q9NZ08	ERAP1_HUMAN	type 1 tumor necrosis factor receptor shedding	614	Lumenal (Potential).				angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		CATCCATCATCCTCGTAATGC	0.413		NA											4	49					0	0	0	0
TRIM36	55521	broad.mit.edu	37	5	114499269	114499269	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:114499269G>C	uc003kqs.2	-	2	753	c.244C>G	c.(244-246)CGA>GGA	p.R82G	TRIM36_uc011cwc.1_Missense_Mutation_p.R70G|TRIM36_uc003kqt.2_Intron	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	82	RING-type; degenerate.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		AGCCGAAGTCGAGGACTGCTT	0.453		NA											5	49					0	0	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215474	140215474	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:140215474C>T	uc003lhq.2	+	1	1506	c.1506C>T	c.(1504-1506)CGC>CGT	p.R502R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.R502R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	502	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding	p.R502H(1)		ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCGAGCGCGCGCTGTCGA	0.677		NA											13	79					0	0	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237249	140237249	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:140237249G>C	uc003lhx.2	+	1	1616	c.1616G>C	c.(1615-1617)GGG>GCG	p.G539A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.G539A	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	539	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGATGGGGGCGTGCCG	0.687		NA											5	82					0	0	0	0
SLC34A1	6569	broad.mit.edu	37	5	176824887	176824887	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr5:176824887G>A	uc003mgk.3	+	13	1621	c.1520G>A	c.(1519-1521)CGC>CAC	p.R507H		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	507	Cytoplasmic (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGGGAAACGCACGGCCAAG	0.607		NA											16	63					0	0	0	0
CSNK2B	1460	broad.mit.edu	37	6	31635648	31635648	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:31635648G>C	uc003nvr.1	+	3	416	c.76G>C	c.(76-78)GAT>CAT	p.D26H	BAT4_uc003nvn.2_5'Flank|BAT4_uc003nvo.3_5'Flank|BAT4_uc003nvp.3_5'Flank|BAT4_uc003nvq.2_5'Flank|CSNK2B_uc010jta.1_Missense_Mutation_p.D26H|CSNK2B_uc003nvs.1_Missense_Mutation_p.D26H	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	26					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						CTGACAGGTGGATGAAGACTA	0.458		NA											13	20					0	0	0	0
GLO1	2739	broad.mit.edu	37	6	38670758	38670758	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:38670758G>A	uc003ooc.2	-	1	195	c.73C>T	c.(73-75)CCC>TCC	p.P25S		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	25					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	TTGGTACTGGGGTCCGCGTCG	0.711		NA											3	23					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38704881	38704881	+	Silent	SNP	C	C	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:38704881C>G	uc003ooe.1	+	4	750	c.150C>G	c.(148-150)CTC>CTG	p.L50L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CGAAAGGACTCTTAAATGGAA	0.398		NA											5	83					0	0	0	0
SLC17A5	26503	broad.mit.edu	37	6	74331548	74331548	+	Silent	SNP	G	G	A	rs147732875		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:74331548G>A	uc003phn.3	-	7	1085	c.957C>T	c.(955-957)ATC>ATT	p.I319I	SLC17A5_uc010kax.2_Intron|SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Silent_p.I188I	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	319					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						TGAACCTTAGGATCTCCTTCA	0.313		NA											9	21					0	0	0	0
C6orf174	387104	broad.mit.edu	37	6	127796911	127796911	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:127796911C>T	uc003qbd.2	-	6	3125	c.2260G>A	c.(2260-2262)GAG>AAG	p.E754K	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	754						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		GCGTCGCTCTCGGCGTCGCTG	0.701		NA											11	83					0	0	0	0
C6orf97	80129	broad.mit.edu	37	6	151857487	151857487	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr6:151857487C>T	uc003qol.2	+	2	181	c.92C>T	c.(91-93)ACG>ATG	p.T31M		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	31	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GTCCCGGTCACGCGGGAGCAG	0.433		NA											5	57					0	0	0	0
ELN	2006	broad.mit.edu	37	7	73474265	73474265	+	Silent	SNP	T	T	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:73474265T>A	uc003tzw.2	+	23	1573	c.1482T>A	c.(1480-1482)GGT>GGA	p.G494G	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Silent_p.G488G|ELN_uc003tzz.2_Silent_p.G407G|ELN_uc003tzo.2_Silent_p.G455G|ELN_uc003tzp.2_Silent_p.G399G|ELN_uc003tzq.2_Silent_p.G352G|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Silent_p.G469G|ELN_uc003tzt.2_Silent_p.G493G|ELN_uc003tzu.2_Silent_p.G474G|ELN_uc003tzv.2_Silent_p.G459G|ELN_uc003tzx.2_Silent_p.G478G|ELN_uc011kff.1_Silent_p.G488G|ELN_uc003tzy.2_Silent_p.G464G	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	517	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGGCTCCTGGTGTCGGTGTGG	0.567		NA	T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						9	174					0	0	0	0
ELN	2006	broad.mit.edu	37	7	73474268	73474268	+	Silent	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:73474268C>T	uc003tzw.2	+	23	1576	c.1485C>T	c.(1483-1485)GTC>GTT	p.V495V	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Silent_p.V489V|ELN_uc003tzz.2_Silent_p.V408V|ELN_uc003tzo.2_Silent_p.V456V|ELN_uc003tzp.2_Silent_p.V400V|ELN_uc003tzq.2_Silent_p.V353V|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Silent_p.V470V|ELN_uc003tzt.2_Silent_p.V494V|ELN_uc003tzu.2_Silent_p.V475V|ELN_uc003tzv.2_Silent_p.V460V|ELN_uc003tzx.2_Silent_p.V479V|ELN_uc011kff.1_Silent_p.V489V|ELN_uc003tzy.2_Silent_p.V465V	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	518	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CTCCTGGTGTCGGTGTGGCTC	0.577		NA	T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						15	174					0	0	0	0
ELN	2006	broad.mit.edu	37	7	73474271	73474271	+	Silent	SNP	T	T	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:73474271T>C	uc003tzw.2	+	23	1579	c.1488T>C	c.(1486-1488)GGT>GGC	p.G496G	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Silent_p.G490G|ELN_uc003tzz.2_Silent_p.G409G|ELN_uc003tzo.2_Silent_p.G457G|ELN_uc003tzp.2_Silent_p.G401G|ELN_uc003tzq.2_Silent_p.G354G|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Silent_p.G471G|ELN_uc003tzt.2_Silent_p.G495G|ELN_uc003tzu.2_Silent_p.G476G|ELN_uc003tzv.2_Silent_p.G461G|ELN_uc003tzx.2_Silent_p.G480G|ELN_uc011kff.1_Silent_p.G490G|ELN_uc003tzy.2_Silent_p.G466G	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	519	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CTGGTGTCGGTGTGGCTCCTG	0.587		NA	T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						15	173					0	0	0	0
ACTL6B	51412	broad.mit.edu	37	7	100246281	100246281	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:100246281G>A	uc003uvy.2	-	7	674	c.567C>T	c.(565-567)ATC>ATT	p.I189I	ACTL6B_uc003uvx.1_5'UTR|ACTL6B_uc003uvz.2_RNA	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	189					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGGACTTGACGATGCCTAGAA	0.597		NA											9	13					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100678877	100678877	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:100678877G>T	uc003uxp.1	+	3	4233	c.4180G>T	c.(4180-4182)GGA>TGA	p.G1394*	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1394	Extracellular (Potential).|59 X approximate tandem repeats.|21.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTAGTGAAGGAACCACTCC	0.507		NA											91	272					4.22e-46	4.93e-46	1	0
IMMP2L	83943	broad.mit.edu	37	7	110303748	110303748	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:110303748G>A	uc003vfq.1	-	6	881	c.438C>T	c.(436-438)GCC>GCT	p.A146A	IMMP2L_uc010ljr.1_Silent_p.A146A	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	146					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		GGATATGTGTGGCATGGGCAT	0.418		NA											6	48					0	0	0	0
FBXO43	286151	broad.mit.edu	37	8	101149817	101149817	+	Silent	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:101149817G>A	uc003yjd.2	-	3	2363	c.1650C>T	c.(1648-1650)ATC>ATT	p.I550I	FBXO43_uc003yje.2_Silent_p.I516I|FBXO43_uc010mbp.1_Silent_p.I550I	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	550					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TCAGTTGTGTGATATAAAATT	0.303		NA											17	20					0	0	0	0
UBR5	51366	broad.mit.edu	37	8	103309160	103309160	+	Missense_Mutation	SNP	G	G	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:103309160G>A	uc003ykr.1	-	28	3659	c.3626C>T	c.(3625-3627)ACG>ATG	p.T1209M	UBR5_uc003yks.1_Missense_Mutation_p.T1209M	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1209	UBR-type.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGCACATTCCGTACAACAACA	0.318		NA											4	33					0	0	0	0
ZFAT	57623	broad.mit.edu	37	8	135620985	135620985	+	Missense_Mutation	SNP	T	T	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:135620985T>C	uc003yup.2	-	5	947	c.772A>G	c.(772-774)ATG>GTG	p.M258V	ZFAT_uc003yun.2_Missense_Mutation_p.M246V|ZFAT_uc003yuo.2_Missense_Mutation_p.M246V|ZFAT_uc010meh.2_Missense_Mutation_p.M246V|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.M246V|ZFAT_uc010mej.2_Missense_Mutation_p.M196V|ZFAT_uc003yur.2_Missense_Mutation_p.M246V	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTTGACTTCATTGGTTGCTCA	0.483		NA											52	42					0	0	0	0
ZC3H3	23144	broad.mit.edu	37	8	144589967	144589967	+	Missense_Mutation	SNP	G	G	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr8:144589967G>C	uc003yyd.2	-	4	1693	c.1664C>G	c.(1663-1665)CCC>CGC	p.P555R		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	555					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CAGGGGGAAGGGCGGGGCGCT	0.667		NA											32	45					0	0	0	0
ACO1	48	broad.mit.edu	37	9	32423392	32423392	+	Missense_Mutation	SNP	C	C	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:32423392C>T	uc003zqw.3	+	9	1201	c.1046C>T	c.(1045-1047)CCT>CTT	p.P349L	ACO1_uc010mjh.1_Missense_Mutation_p.P183L|ACO1_uc003zqx.3_Missense_Mutation_p.P349L|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	349					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TTCAATGACCCTTCTCAAGAC	0.398		NA											6	43					0	0	0	0
C9orf170	401535	broad.mit.edu	37	9	89771559	89771559	+	Silent	SNP	T	T	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:89771559T>C	uc004apa.1	+	2	327	c.240T>C	c.(238-240)TCT>TCC	p.S80S		NM_001001709	NP_001001709	A2RU37	CI170_HUMAN	hypothetical protein LOC401535	80											0						ggagaaagtctgatttaggag	0.124		NA											4	20					0	0	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900135	112900135	+	Missense_Mutation	SNP	G	G	A	rs142423891		TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:112900135G>A	uc004bei.2	+	9	3199	c.3007G>A	c.(3007-3009)GTC>ATC	p.V1003I	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.V771I|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.V771I|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.V581I|AKAP2_uc011lwi.1_Missense_Mutation_p.V629I|AKAP2_uc004bem.2_Missense_Mutation_p.V629I|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.V589I|AKAP2_uc011lwj.1_Missense_Mutation_p.V540I|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.V540I	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	540							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGGAGAAGGCGTCTCCAAGTC	0.532		NA											5	46					0	0	0	0
RBBP7	5931	broad.mit.edu	37	X	16887232	16887232	+	Missense_Mutation	SNP	C	C	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:16887232C>A	uc004cxt.2	-	2	486	c.128G>T	c.(127-129)AGT>ATT	p.S43I	RBBP7_uc004cxs.1_Missense_Mutation_p.S87I|RBBP7_uc004cxu.2_Missense_Mutation_p.S43I	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	43					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					AACGGTAAGACTGGGCCACTG	0.403		NA											8	28					1.13e-05	1.25e-05	1	0
RBBP7	5931	broad.mit.edu	37	X	16887237	16887237	+	Missense_Mutation	SNP	C	C	G			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:16887237C>G	uc004cxt.2	-	2	481	c.123G>C	c.(121-123)TGG>TGC	p.W41C	RBBP7_uc004cxs.1_Missense_Mutation_p.W85C|RBBP7_uc004cxu.2_Missense_Mutation_p.W41C	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	41					cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					TAAGACTGGGCCACTGAAGAG	0.393		NA											10	27					0	0	0	0
DGKK	139189	broad.mit.edu	37	X	50119144	50119144	+	Missense_Mutation	SNP	A	A	T			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:50119144A>T	uc010njr.1	-	25	3353	c.3293T>A	c.(3292-3294)ATC>AAC	p.I1098N		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1098					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					ATGCTGGTGGATCTTGCTCAG	0.478		NA											6	4					0	0	0	0
KLHL4	56062	broad.mit.edu	37	X	86877396	86877396	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chrX:86877396C>A	uc004efb.2	+	5	1292	c.1110C>A	c.(1108-1110)TAC>TAA	p.Y370*	KLHL4_uc004efa.2_Nonsense_Mutation_p.Y370*	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	370						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TGCTTTCTTACATCAGACTGC	0.413		NA											10	34					0.00010058	0.000108858	1	0
HCRTR1	3061	broad.mit.edu	37	1	32084929	32084931	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr1:32084929_32084931delGAG	uc009vtx.2	+	3	521_523	c.136_138delGAG	c.(136-138)GAGdel	p.E46del	HCRTR1_uc001btb.2_Intron|HCRTR1_uc001btc.3_In_Frame_Del_p.19_20MS>I|HCRTR1_uc001btd.2_In_Frame_Del_p.E46del|HCRTR1_uc010ogl.1_In_Frame_Del_p.E46del	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	46	Extracellular (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		AAAACAGTATGAGTGGGTCCTCA	0.606		NA											27	110	---	---	---	---	NA	NA	NA	NA
PAMR1	25891	broad.mit.edu	37	11	35513669	35513670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr11:35513669_35513670insC	uc001mwg.2	-	3	345_346	c.302_303insG	c.(301-303)GGTfs	p.G101fs	PAMR1_uc001mwf.2_Frame_Shift_Ins_p.G101fs|PAMR1_uc010rew.1_Frame_Shift_Ins_p.G101fs|PAMR1_uc010rex.1_Frame_Shift_Ins_p.G61fs	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	101					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CATCCAAGGTACCCCCCCATGA	0.52		NA											27	606	---	---	---	---	NA	NA	NA	NA
KRTAP4-9	100132386	broad.mit.edu	37	17	39261988	39261988	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr17:39261988delC	uc010wfp.1	+	1	348	c.348delC	c.(346-348)CACfs	p.H116fs		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	116	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].|18.					keratin filament					0						CCTGCTGCCACCCTAGGtgct	0.353		NA											8	12	---	---	---	---	NA	NA	NA	NA
ProSAPiP1	9762	broad.mit.edu	37	20	3146179	3146179	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr20:3146179delG	uc002wia.1	-	2	2685	c.1287delC	c.(1285-1287)GCCfs	p.A429fs	ProSAPiP1_uc002wib.1_Frame_Shift_Del_p.A383fs	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	429	Potential.					cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						GCAGGAAGTCGGCCTGCTCCT	0.662		NA											20	31	---	---	---	---	NA	NA	NA	NA
CNTN6	27255	broad.mit.edu	37	3	1424634	1424636	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr3:1424634_1424636delAGA	uc003boz.2	+	18	2442_2444	c.2175_2177delAGA	c.(2173-2178)CCAGAA>CCA	p.E727del	CNTN6_uc011asj.1_In_Frame_Del_p.E655del|CNTN6_uc003bpa.2_In_Frame_Del_p.E727del	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	727	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AGTCAATTCCAGAAGAACTGCAG	0.384		NA											12	29	---	---	---	---	NA	NA	NA	NA
ZMIZ2	83637	broad.mit.edu	37	7	44805118	44805119	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr7:44805118_44805119insC	uc003tlr.2	+	16	2305_2306	c.2182_2183insC	c.(2182-2184)GCCfs	p.A728fs	ZMIZ2_uc003tlq.2_Frame_Shift_Ins_p.A670fs|ZMIZ2_uc003tls.2_Frame_Shift_Ins_p.A702fs|ZMIZ2_uc003tlt.2_Frame_Shift_Ins_p.A351fs|ZMIZ2_uc010kyj.2_Frame_Shift_Ins_p.A250fs|ZMIZ2_uc003tlu.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	728	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CCCCGGCGCTGCCCCCTTTGCC	0.698		NA											3	6	---	---	---	---	NA	NA	NA	NA
DOCK8	81704	broad.mit.edu	37	9	446516	446517	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:446516_446517insCA	uc003zgf.2	+	44	5839_5840	c.5727_5728insCA	c.(5725-5730)CTGCATfs	p.L1909fs	DOCK8_uc010mgu.2_Frame_Shift_Ins_p.L1211fs|DOCK8_uc010mgv.2_Frame_Shift_Ins_p.L1809fs|DOCK8_uc003zgk.2_Frame_Shift_Ins_p.L1367fs	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1909_1910					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GGGGAGAGCTGCATGAGCAGTA	0.545		NA											12	52	---	---	---	---	NA	NA	NA	NA
FLJ46321	389763	broad.mit.edu	37	9	84606915	84606923	+	In_Frame_Del	DEL	GCACAGCGA	GCACAGCGA	-			TCGA-CV-7423-01A-11D-2078-08	TCGA-CV-7423-10A-01D-2078-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a99653e0-2751-4423-93f7-abcf258c9868	4c6dc4b7-913a-4c75-9af4-c3fda9204cf1	g.chr9:84606915_84606923delGCACAGCGA	uc004amn.2	+	4	1577_1585	c.1530_1538delGCACAGCGA	c.(1528-1539)TTGCACAGCGAG>TTG	p.HSE511del		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	511_513						integral to membrane					0						TCCCATCTTTGCACAGCGAGTCTCTGCAT	0.445		NA											8	29	---	---	---	---	NA	NA	NA	NA