Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16892272	16892272	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:16892272C>G	uc009vos.1	-	28	4033	c.3145G>C	c.(3145-3147)GAG>CAG	p.E1049Q	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1049	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACTTCAGGCTCTACTGCCTCC	0.483		NA											21	394					0	0	0	0
EPHB2	2048	broad.mit.edu	37	1	23219501	23219501	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:23219501G>A	uc009vqj.1	+	7	1698	c.1553G>A	c.(1552-1554)CGC>CAC	p.R518H	EPHB2_uc001bge.2_Missense_Mutation_p.R518H|EPHB2_uc001bgf.2_Missense_Mutation_p.R518H|EPHB2_uc010odu.1_Missense_Mutation_p.R518H	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	518	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GGTTACGGGCGCTACAGCGGC	0.577		NA							Hereditary_Prostate_Cancer				19	50					0	0	0	0
AK3L1	205	broad.mit.edu	37	1	65684449	65684449	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:65684449C>T	uc001dby.2	+	4	525	c.278C>T	c.(277-279)ACA>ATA	p.T93I	AK3L1_uc009wan.2_Missense_Mutation_p.T41I|AK3L1_uc001dbz.2_Missense_Mutation_p.T93I|AK3L1_uc001dca.2_Missense_Mutation_p.T93I	NM_203464	NP_982289	P27144	KAD4_HUMAN	adenylate kinase 3-like 1 isoform 7	93	AMP.					mitochondrial matrix	adenylate kinase activity|ATP binding|GTP binding				0						TTTCCTAGGACATTAGGACAA	0.388		NA											9	42					0	0	0	0
C1orf173	127254	broad.mit.edu	37	1	75072553	75072553	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:75072553C>T	uc001dgg.2	-	10	1440	c.1221G>A	c.(1219-1221)CCG>CCA	p.P407P	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.P201P	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	407										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCGGCAAAGACGGTTTTTTGT	0.418		NA											23	115					0	0	0	0
CCDC76	54482	broad.mit.edu	37	1	100602603	100602603	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:100602603C>A	uc001dsv.2	+	3	242	c.223C>A	c.(223-225)CAT>AAT	p.H75N	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.H75N	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	75	CHHC-type.				tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		ACTAGCAAAGCATTTGAAAAA	0.318		NA											10	55					2.81e-09	3.49e-09	1	0
C1orf51	148523	broad.mit.edu	37	1	150255844	150255844	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:150255844G>C	uc001euh.2	+	2	303	c.167G>C	c.(166-168)CGG>CCG	p.R56P	C1orf51_uc001eui.2_Intron|C1orf51_uc001euj.2_Missense_Mutation_p.R56P	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	56											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAGGTTCACGGCCCAGCCCG	0.602		NA											8	170					0	0	0	0
OR10R2	343406	broad.mit.edu	37	1	158450102	158450102	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:158450102C>T	uc010pik.1	+	1	435	c.435C>T	c.(433-435)GCC>GCT	p.A145A	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	145	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					GCTATGCTGCCATTTGTCACC	0.488		NA											45	205					0	0	0	0
PCNXL2	80003	broad.mit.edu	37	1	233313598	233313598	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:233313598G>T	uc001hvl.2	-	17	3458	c.3223C>A	c.(3223-3225)CTG>ATG	p.L1075M	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1075						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GACTCTGCCAGATTTTGATGT	0.428		NA											4	52					1.24e-05	1.49e-05	1	0
CAMK1D	57118	broad.mit.edu	37	10	12870837	12870837	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:12870837G>A	uc001ilo.2	+	11	1344	c.1109G>A	c.(1108-1110)CGG>CAG	p.R370Q		NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	370						calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		GGAGCCGAGCGGAGACCCAGG	0.642		NA											7	26					0	0	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819421	50819421	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:50819421G>C	uc001jhw.2	+	1	1075	c.635G>C	c.(634-636)CGT>CCT	p.R212P	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	212	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GAGCGCAGTCGTGCACTGGGC	0.672		NA											4	13					0	0	0	0
TACR2	6865	broad.mit.edu	37	10	71175838	71175838	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:71175838C>T	uc001jpn.2	-	1	837	c.242G>A	c.(241-243)TGC>TAC	p.C81Y		NM_001057	NP_001048	P21452	NK2R_HUMAN	tachykinin receptor 2	81	Helical; Name=2; (Potential).				excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			prostate(1)	1					Clonidine(DB00575)|Octreotide(DB00104)	GGCAGCCATGCAGAGGTCAGC	0.547		NA											11	16					0	0	0	0
LOC729020	729020	broad.mit.edu	37	10	105005908	105005908	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:105005908C>T	uc009xxi.2	+	1	265	c.155C>T	c.(154-156)CCT>CTT	p.P52L	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	52					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TTTGGTCACCCTGTGGTAGAA	0.507		NA											37	188					0	0	0	0
PDCD11	22984	broad.mit.edu	37	10	105201732	105201732	+	Silent	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr10:105201732G>A	uc001kwy.1	+	31	4794	c.4707G>A	c.(4705-4707)ACG>ACA	p.T1569T		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1569					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACCAAGCCACGGTGCTGTATT	0.572		NA											5	35					0	0	0	0
C11orf41	25758	broad.mit.edu	37	11	33564673	33564673	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:33564673G>C	uc001mup.3	+	1	797	c.673G>C	c.(673-675)GAA>CAA	p.E225Q	C11orf41_uc001mun.1_Missense_Mutation_p.E225Q	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	225						integral to membrane				ovary(2)	2						TCCTGTGCCAGAAATGCCCAC	0.537		NA									OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	74					0	0	0	0
OR5D18	219438	broad.mit.edu	37	11	55587567	55587567	+	Silent	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:55587567C>G	uc010rin.1	+	1	462	c.462C>G	c.(460-462)GTC>GTG	p.V154V		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CCTGGGGAGTCTCATGTTCCT	0.478		NA											34	138					0	0	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756943	56756943	+	Silent	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:56756943T>G	uc010rjp.1	+	1	555	c.555T>G	c.(553-555)CTT>CTG	p.L185L		NM_001005323	NP_001005323	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						CCCCTATTCTTGCTCTTTCAT	0.403		NA											48	221					0	0	0	0
PICALM	8301	broad.mit.edu	37	11	85779753	85779753	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr11:85779753T>G	uc001pbm.2	-	1	356	c.70A>C	c.(70-72)AAG>CAG	p.K24Q	PICALM_uc001pbl.2_Missense_Mutation_p.K24Q|PICALM_uc001pbn.2_Missense_Mutation_p.K24Q|PICALM_uc010rtl.1_Intron	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	24	ENTH.				clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				CATACTGTCTTGGATACGGCA	0.537		NA	T	MLLT10|MLL	TALL|AML|								10	16					0	0	0	0
FOXJ2	55810	broad.mit.edu	37	12	8200482	8200482	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:8200482T>A	uc001qtu.2	+	7	1907	c.822T>A	c.(820-822)TTT>TTA	p.F274L	FOXJ2_uc001qtt.1_Missense_Mutation_p.F274L	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	274					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		CTGCAGGCTTTTCTTCTCTCC	0.368		NA											18	67					0	0	0	0
ATF1	466	broad.mit.edu	37	12	51173954	51173954	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:51173954C>T	uc001rww.3	+	2	304	c.26C>T	c.(25-27)ACG>ATG	p.T9M	ATF1_uc010smu.1_Translation_Start_Site	NM_005171	NP_005162	P18846	ATF1_HUMAN	activating transcription factor 1	9					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329						AAGAGTACCACGTCAGAGACA	0.408		NA	T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								68	177					0	0	0	0
RIC8B	55188	broad.mit.edu	37	12	107254159	107254159	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:107254159G>T	uc001tlx.2	+	8	1545	c.1420G>T	c.(1420-1422)GAC>TAC	p.D474Y	RIC8B_uc001tlw.2_Missense_Mutation_p.D474Y|RIC8B_uc001tly.2_Missense_Mutation_p.D434Y|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	474					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						TGAGGACACAGACACTGAAGA	0.438		NA											6	31					3.6e-05	4.27e-05	1	0
ATP2A2	488	broad.mit.edu	37	12	110783837	110783837	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:110783837C>T	uc001tqk.3	+	19	3336	c.2773C>T	c.(2773-2775)CCC>TCC	p.P925S	ATP2A2_uc001tql.3_Missense_Mutation_p.P925S|ATP2A2_uc010sxy.1_Missense_Mutation_p.P898S|ATP2A2_uc001tqn.3_Missense_Mutation_p.P2S|ATP2A2_uc009zvn.2_5'Flank	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	925	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						GCTGAGGATGCCCCCCTGGGA	0.577		NA											4	83					0	0	0	0
C12orf52	84934	broad.mit.edu	37	12	113624689	113624689	+	Silent	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:113624689G>A	uc001tur.1	+	3	606	c.138G>A	c.(136-138)CGG>CGA	p.R46R	DDX54_uc001tuq.3_5'Flank|DDX54_uc001tup.2_5'Flank|C12orf52_uc009zwg.1_Silent_p.R46R|C12orf52_uc001tus.1_Silent_p.R46R|C12orf52_uc001tut.1_Silent_p.R70R	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	46					negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						CAGGCACCCGGCCTACCCCAC	0.642		NA											7	31					0	0	0	0
FAM155A	728215	broad.mit.edu	37	13	107863084	107863084	+	Missense_Mutation	SNP	A	A	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr13:107863084A>T	uc001vql.2	-	2	1451	c.935T>A	c.(934-936)CTC>CAC	p.L312H		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	312						integral to membrane	binding			skin(1)	1						CTGGGAACAGAGCCAGGCTTT	0.413		NA									OREG0022506	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	41					0	0	0	0
COL4A2	1284	broad.mit.edu	37	13	111117869	111117869	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr13:111117869C>T	uc001vqx.2	+	25	2183	c.1894C>T	c.(1894-1896)CGT>TGT	p.R632C		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	632	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAAAGGCCAACGTGGTTTCCC	0.632		NA											9	34					0	0	0	0
ACYP1	97	broad.mit.edu	37	14	75520263	75520263	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:75520263T>C	uc001xrg.2	-	3	272	c.184A>G	c.(184-186)ATG>GTG	p.M62V	MLH3_uc001xrd.1_5'Flank|MLH3_uc001xre.1_5'Flank|ACYP1_uc001xrf.2_3'UTR	NM_001107	NP_001098	P07311	ACYP1_HUMAN	acylphosphatase 1 isoform a	62	Acylphosphatase-like.				phosphate metabolic process		acylphosphatase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00646)		CATTCCTGCATATGACGCACC	0.468		NA											49	138					0	0	0	0
MARK3	4140	broad.mit.edu	37	14	103958157	103958157	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:103958157A>G	uc001ymz.3	+	15	2296	c.1630A>G	c.(1630-1632)ATC>GTC	p.I544V	MARK3_uc001ymx.3_Missense_Mutation_p.I544V|MARK3_uc001ymw.3_Missense_Mutation_p.I544V|MARK3_uc001yna.3_Missense_Mutation_p.I528V|MARK3_uc001ymy.3_Missense_Mutation_p.I465V|MARK3_uc010awp.2_Missense_Mutation_p.I567V|MARK3_uc010tyb.1_Missense_Mutation_p.I339V|MARK3_uc010awq.2_Missense_Mutation_p.I126V	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	544							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			AACACACAGTATCAGTAGTGC	0.488		NA											11	45					0	0	0	0
FOXB1	27023	broad.mit.edu	37	15	60297484	60297484	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr15:60297484C>A	uc002agj.1	+	2	801	c.322C>A	c.(322-324)CGC>AGC	p.R108S	FOXB1_uc010bgh.1_Intron	NM_012182	NP_036314	Q99853	FOXB1_HUMAN	forkhead box B1	108					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|central_nervous_system(1)	2						GCGCCGCAAGCGCTTCAAGGT	0.706		NA											10	17					6.4e-05	7.42e-05	1	0
TLN2	83660	broad.mit.edu	37	15	62989996	62989996	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr15:62989996G>A	uc002alb.3	+	12	1402	c.1402G>A	c.(1402-1404)GTT>ATT	p.V468I		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	468					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GACCTTCAACGTTGGCAGCAT	0.667		NA											17	25					0	0	0	0
SLC38A7	55238	broad.mit.edu	37	16	58705074	58705074	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr16:58705074C>A	uc002eod.1	-	10	1499	c.1106G>T	c.(1105-1107)CGG>CTG	p.R369L	SLC38A7_uc002eob.1_RNA|SLC38A7_uc002eoc.1_Intron|SLC38A7_uc010vil.1_Missense_Mutation_p.R280L	NM_018231	NP_060701	Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	369					amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						CAGCACTCGCCGCCGCCGCTC	0.667		NA											4	24					0.00909568	0.0096745	1	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	48					0	0	0	0
PER1	5187	broad.mit.edu	37	17	8047139	8047139	+	Silent	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:8047139G>A	uc002gkd.2	-	19	2755	c.2517C>T	c.(2515-2517)GCC>GCT	p.A839A	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_Intron	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	839	Nuclear localization signal (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						GTGAGCGCTTGGCTTTGGATC	0.672		NA	T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					16	35					0	0	0	0
HS3ST3B1	9953	broad.mit.edu	37	17	14205268	14205268	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:14205268G>T	uc002goh.1	+	1	763	c.433G>T	c.(433-435)GTG>TTG	p.V145L	MGC12916_uc010vvv.1_5'Flank	NM_006041	NP_006032	Q9Y662	HS3SB_HUMAN	heparan sulfate D-glucosaminyl	145	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Golgi membrane|integral to plasma membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		CATCATCGGCGTGAAGAAGGG	0.667		NA											4	19					2.56e-06	3.1e-06	1	0
KRT31	3881	broad.mit.edu	37	17	39551520	39551520	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:39551520C>G	uc002hwn.2	-	5	906	c.853G>C	c.(853-855)GAG>CAG	p.E285Q	KRT31_uc010cxn.2_Missense_Mutation_p.E285Q	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	285	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GCCTGCAGCTCGATCTCCAGG	0.607		NA											14	64					0	0	0	0
GJC1	10052	broad.mit.edu	37	17	42882699	42882699	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:42882699C>A	uc002ihj.2	-	2	998	c.487G>T	c.(487-489)GAT>TAT	p.D163Y	GJC1_uc002ihk.2_Missense_Mutation_p.D163Y|GJC1_uc002ihl.2_Missense_Mutation_p.D163Y|GJC1_uc010czx.2_Missense_Mutation_p.D163Y|GJC1_uc010czy.1_Missense_Mutation_p.D24Y	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45	163	Cytoplasmic (Potential).				cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				CGTCGGCCATCATGCTTAGGT	0.478		NA											27	127					6.13e-19	7.88e-19	1	0
HELZ	9931	broad.mit.edu	37	17	65174905	65174905	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr17:65174905T>C	uc010wqk.1	-	13	1487	c.1300A>G	c.(1300-1302)ATT>GTT	p.I434V	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.I434V	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GAGAGGGGAATTTGGTATCTG	0.383		NA											5	102					0	0	0	0
MC5R	4161	broad.mit.edu	37	18	13826449	13826449	+	Silent	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr18:13826449C>A	uc010xaf.1	+	1	685	c.685C>A	c.(685-687)CGG>AGG	p.R229R		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	229	Cytoplasmic (Potential).			ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CAGCTCTGCGCGGCAGAGGAC	0.617		NA											35	137					3.04e-20	3.93e-20	1	0
ZNF99	7652	broad.mit.edu	37	19	22940099	22940099	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr19:22940099T>G	uc010xrh.1	-	6	2232	c.2232A>C	c.(2230-2232)AAA>AAC	p.K744N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATTTGTAGGGTTTCTTTCCAG	0.348		NA											12	55					0	0	0	0
SIGLEC6	946	broad.mit.edu	37	19	52033054	52033054	+	Silent	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr19:52033054T>G	uc002pwy.2	-	5	1098	c.936A>C	c.(934-936)GCA>GCC	p.A312A	SIGLEC6_uc002pwz.2_Silent_p.A296A|SIGLEC6_uc002pxa.2_Silent_p.A312A|SIGLEC6_uc010ydb.1_Silent_p.A249A|SIGLEC6_uc010ydc.1_Silent_p.A312A|SIGLEC6_uc010eoz.1_Silent_p.A290A|SIGLEC6_uc010epb.1_Silent_p.A265A|SIGLEC6_uc010epa.1_Silent_p.A301A	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	312	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CTCCTTCTTCTGCAGACCCTA	0.607		NA											14	32					0	0	0	0
LCLAT1	253558	broad.mit.edu	37	2	30790956	30790956	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:30790956C>T	uc002rnj.2	+	6	865	c.656C>T	c.(655-657)GCT>GTT	p.A219V	LCLAT1_uc010ymp.1_Missense_Mutation_p.A57V|LCLAT1_uc002rnk.1_Missense_Mutation_p.A219V|LCLAT1_uc002rnl.2_Missense_Mutation_p.A181V|LCLAT1_uc010ymq.1_Missense_Mutation_p.A181V	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	219					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						AATGCATTTGCTGAAAAAAAT	0.338		NA											10	54					0	0	0	0
MOGS	7841	broad.mit.edu	37	2	74689540	74689540	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:74689540A>G	uc010ffj.2	-	4	1539	c.1376T>C	c.(1375-1377)GTT>GCT	p.V459A	MOGS_uc010ffh.2_Missense_Mutation_p.V184A|MOGS_uc010yrt.1_Missense_Mutation_p.V340A|MOGS_uc010ffi.2_Missense_Mutation_p.V353A	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	459	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						CCACCGCTGAACCACCAGCTG	0.597		NA											6	34					0	0	0	0
REEP1	65055	broad.mit.edu	37	2	86459838	86459838	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:86459838C>T	uc002srh.3	-	6	649	c.505G>A	c.(505-507)GGC>AGC	p.G169S	REEP1_uc010ytg.1_Missense_Mutation_p.G148S|REEP1_uc010yth.1_Missense_Mutation_p.G142S|REEP1_uc010yti.1_Silent_p.R90R	NM_022912	NP_075063	Q9H902	REEP1_HUMAN	receptor accessory protein 1 isoform 2	169					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0						GGTGGGGGGCCCGAGGGAGCA	0.647		NA											9	25					0	0	0	0
WIPF1	7456	broad.mit.edu	37	2	175437112	175437112	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:175437112A>G	uc002uiy.2	-	6	753	c.421T>C	c.(421-423)TTT>CTT	p.F141L	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.F141L|WIPF1_uc010fqt.1_Missense_Mutation_p.F141L|WIPF1_uc002ujc.1_Missense_Mutation_p.F141L|WIPF1_uc002uiz.2_Missense_Mutation_p.F141L|WIPF1_uc002ujb.1_Missense_Mutation_p.F141L|WIPF1_uc010zep.1_Missense_Mutation_p.F141L	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	141					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GGGGGTGAAAAGGGTTTCGCA	0.562		NA											3	51					0	0	0	0
ERBB4	2066	broad.mit.edu	37	2	212426697	212426697	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:212426697C>G	uc002veg.1	-	20	2516	c.2418G>C	c.(2416-2418)GAG>GAC	p.E806D	ERBB4_uc002veh.1_Missense_Mutation_p.E806D|ERBB4_uc010zji.1_Missense_Mutation_p.E796D|ERBB4_uc010zjj.1_Missense_Mutation_p.E796D|ERBB4_uc010fut.1_Missense_Mutation_p.E806D	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	806	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CGTGGACATACTCCAACAGGC	0.483		NA								TSP Lung(8;0.080)			27	106					0	0	0	0
MCM8	84515	broad.mit.edu	37	20	5974238	5974238	+	Missense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:5974238C>G	uc002wmi.2	+	18	2704	c.2327C>G	c.(2326-2328)GCG>GGG	p.A776G	MCM8_uc002wmj.2_Missense_Mutation_p.A760G|MCM8_uc002wmk.2_Missense_Mutation_p.A816G|MCM8_uc002wml.2_Missense_Mutation_p.A776G|MCM8_uc010gbp.2_Missense_Mutation_p.A729G|MCM8_uc002wmm.2_Missense_Mutation_p.A314G	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	776					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						AGGTCAACAGCGAAAAGATTT	0.368		NA											18	93					0	0	0	0
PKIG	11142	broad.mit.edu	37	20	43246985	43246985	+	Missense_Mutation	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:43246985G>T	uc002xmg.2	+	6	740	c.211G>T	c.(211-213)GAT>TAT	p.D71Y	PKIG_uc002xmh.2_Missense_Mutation_p.D71Y|PKIG_uc002xmi.2_Missense_Mutation_p.D71Y	NM_181805	NP_861521	Q9Y2B9	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma	71							cAMP-dependent protein kinase inhibitor activity|protein binding				0		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			CCAGAGCAGCGATGGGACCAC	0.587		NA											37	132					9.63e-15	1.22e-14	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47591350	47591350	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr20:47591350C>T	uc002xtx.3	+	13	1865	c.1713C>T	c.(1711-1713)CTC>CTT	p.L571L		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	571					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TGTCCATTCTCAAGTGCATGG	0.507		NA											8	17					0	0	0	0
SON	6651	broad.mit.edu	37	21	34931551	34931551	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr21:34931551G>A	uc002yse.1	+	5	6386	c.6337G>A	c.(6337-6339)GCA>ACA	p.A2113T	SON_uc002ysc.2_Missense_Mutation_p.A2113T|SON_uc002ysd.2_Missense_Mutation_p.A1104T|SON_uc002ysf.1_Missense_Mutation_p.A141T|SON_uc002ysg.2_Missense_Mutation_p.A1104T	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2113					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TAAACAGATCGCACAGAGTAA	0.308		NA											12	42					0	0	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30951241	30951241	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr22:30951241C>A	uc003aig.1	-	4	1111	c.971G>T	c.(970-972)CGG>CTG	p.R324L	GAL3ST1_uc003aih.1_Missense_Mutation_p.R324L|GAL3ST1_uc003aii.1_Missense_Mutation_p.R324L|GAL3ST1_uc010gvz.1_Missense_Mutation_p.R324L	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	324	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CATGCGCTCCCGCCCGAAGGC	0.711		NA											5	10					3.6e-05	4.27e-05	1	0
TUBGCP6	85378	broad.mit.edu	37	22	50664505	50664505	+	Missense_Mutation	SNP	T	T	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr22:50664505T>A	uc003bkb.1	-	9	2319	c.1807A>T	c.(1807-1809)AAC>TAC	p.N603Y	TUBGCP6_uc010har.1_Missense_Mutation_p.N603Y|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'Flank|TUBGCP6_uc003bkd.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	603					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TTCAGCAGGTTAATGGTCTTT	0.582		NA											6	140					0	0	0	0
STAB1	23166	broad.mit.edu	37	3	52557481	52557481	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:52557481C>A	uc003dej.2	+	65	7253	c.7179C>A	c.(7177-7179)AAC>AAA	p.N2393K	STAB1_uc003dek.1_Missense_Mutation_p.N408K|STAB1_uc003del.2_Missense_Mutation_p.N280K	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2393	Extracellular (Potential).|FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ATGCCTCCAACGCCACCCTCC	0.617		NA											9	21					7.48e-07	9.22e-07	1	0
GTF2E1	2960	broad.mit.edu	37	3	120469672	120469672	+	Nonsense_Mutation	SNP	C	C	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:120469672C>G	uc003edz.3	+	2	387	c.273C>G	c.(271-273)TAC>TAG	p.Y91*	GTF2E1_uc003edy.2_Nonsense_Mutation_p.Y91*	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	91	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GCCATAACTACTACTTCATCA	0.398		NA											9	38					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			10	99					0	0	0	0
MEPE	56955	broad.mit.edu	37	4	88755893	88755893	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:88755893C>T	uc003hqy.2	+	2	66	c.27C>T	c.(25-27)CTC>CTT	p.L9L	MEPE_uc010ikn.2_5'UTR	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	9					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TGGGACTACTCCTTTTCAGTG	0.368		NA											17	76					0	0	0	0
FAM190A	401145	broad.mit.edu	37	4	91229530	91229530	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:91229530C>T	uc003hsv.3	+	2	435	c.95C>T	c.(94-96)TCA>TTA	p.S32L	FAM190A_uc003hsu.3_Missense_Mutation_p.S32L|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.S32L	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	32	Ser-rich.									large_intestine(1)|ovary(1)	2						CTTCCTTCTTCACCTTCTTCC	0.468		NA											6	34					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134072815	134072815	+	Missense_Mutation	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:134072815T>C	uc003iha.2	+	1	2346	c.1520T>C	c.(1519-1521)ATC>ACC	p.I507T	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.I507T	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	507	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GAGTGCCAGATCCAGGGCATG	0.577		NA											22	71					0	0	0	0
SNX25	83891	broad.mit.edu	37	4	186283809	186283809	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr4:186283809A>G	uc003ixh.2	+	18	2575	c.2386A>G	c.(2386-2388)ATA>GTA	p.I796V	SNX25_uc010ish.2_Missense_Mutation_p.I512V|SNX25_uc003ixi.2_Missense_Mutation_p.I300V	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	796					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CCGCCACGGTATAATAAAAAT	0.388		NA											58	194					0	0	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629960	9629960	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr5:9629960A>G	uc003jem.1	-	1	504	c.185T>C	c.(184-186)ATC>ACC	p.I62T		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	62	Helical; Name=2; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						AACGTAGAAGATGAACAACTG	0.368		NA											22	28					0	0	0	0
MGC42105	167359	broad.mit.edu	37	5	43280501	43280501	+	Silent	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr5:43280501G>C	uc003jno.2	+	4	1862	c.981G>C	c.(979-981)GGG>GGC	p.G327G		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	327							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						GGATGCAAGGGGTGCCATACC	0.502		NA											17	74					0	0	0	0
HIST1H2AG	8969	broad.mit.edu	37	6	27100994	27100994	+	Silent	SNP	G	G	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:27100994G>T	uc003niw.2	+	1	178	c.144G>T	c.(142-144)GCG>GCT	p.A48A	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	48					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GGGCCGGCGCGCCGGTGTATC	0.682		NA											14	58					9.31e-06	1.12e-05	1	0
OR12D2	26529	broad.mit.edu	37	6	29365111	29365111	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:29365111C>T	uc003nmf.3	+	1	696	c.635C>T	c.(634-636)ACA>ATA	p.T212I		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTCTTTCTGACACTTCTCTCC	0.468		NA											22	147					0	0	0	0
VPS52	6293	broad.mit.edu	37	6	33234453	33234453	+	Missense_Mutation	SNP	C	C	T	rs146611103		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:33234453C>T	uc003odm.1	-	12	1372	c.1162G>A	c.(1162-1164)GCC>ACC	p.A388T	VPS52_uc003odn.1_Missense_Mutation_p.A199T	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	388					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TCTAGGAGGGCGTAGTGCTGG	0.522		NA											7	51					0	0	0	0
SLC2A12	154091	broad.mit.edu	37	6	134349644	134349644	+	Missense_Mutation	SNP	G	G	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:134349644G>A	uc003qem.1	-	2	1490	c.1319C>T	c.(1318-1320)GCT>GTT	p.A440V		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	440	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GCTTAATCCAGCATTTAGCAA	0.478		NA											21	73					0	0	0	0
LATS1	9113	broad.mit.edu	37	6	150001304	150001304	+	Missense_Mutation	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:150001304C>A	uc003qmu.1	-	5	2848	c.2300G>T	c.(2299-2301)CGT>CTT	p.R767L	LATS1_uc010kif.1_Missense_Mutation_p.R662L|LATS1_uc003qmv.1_Missense_Mutation_p.R767L	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	767	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ATAATATAGACGAACTACCCA	0.373		NA											22	58					3.8e-18	4.83e-18	1	0
TAGAP	117289	broad.mit.edu	37	6	159457736	159457736	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr6:159457736A>G	uc003qrz.2	-	10	1651	c.1319T>C	c.(1318-1320)CTG>CCG	p.L440P	TAGAP_uc011eft.1_Missense_Mutation_p.L377P|TAGAP_uc003qsa.2_Missense_Mutation_p.L262P	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CTTGATCTTCAGGTCCACCGG	0.612		NA											4	101					0	0	0	0
GPR22	2845	broad.mit.edu	37	7	107114861	107114861	+	Missense_Mutation	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:107114861A>G	uc003vef.2	+	3	1702	c.356A>G	c.(355-357)GAG>GGG	p.E119G	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	119	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						TGTTTCCATGAGGCTTGTGTA	0.388		NA											28	81					0	0	0	0
GRM8	2918	broad.mit.edu	37	7	126746588	126746588	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr7:126746588C>T	uc003vlr.2	-	2	1000	c.689G>A	c.(688-690)AGC>AAC	p.S230N	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.S230N|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	230	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTCCACACCGCTCTCACCATA	0.507		NA								HNSCC(24;0.065)			10	35					0	0	0	0
CSMD1	64478	broad.mit.edu	37	8	3351179	3351179	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:3351179C>T	uc011kwk.1	-	11	1807	c.1417G>A	c.(1417-1419)GGG>AGG	p.G473R		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	473	CUB 3.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCACCTTCCCAGCATCACCA	0.507		NA											4	9					0	0	0	0
TEX15	56154	broad.mit.edu	37	8	30703495	30703495	+	Silent	SNP	T	T	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:30703495T>C	uc003xil.2	-	1	3039	c.3039A>G	c.(3037-3039)ACA>ACG	p.T1013T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1013										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GCTGCAAAGATGTGTGAACTC	0.343		NA											42	98					0	0	0	0
IDO1	3620	broad.mit.edu	37	8	39785691	39785691	+	Missense_Mutation	SNP	T	T	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:39785691T>G	uc003xnm.2	+	10	1313	c.1199T>G	c.(1198-1200)TTG>TGG	p.L400W	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	400					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	AAATCCCTTTTGAAGGAAGGT	0.398		NA											4	15					0	0	0	0
SGK3	23678	broad.mit.edu	37	8	67771691	67771691	+	Missense_Mutation	SNP	G	G	C			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:67771691G>C	uc003xwr.2	+	17	1665	c.1366G>C	c.(1366-1368)GAA>CAA	p.E456Q	SGK3_uc003xwp.2_Missense_Mutation_p.E450Q|SGK3_uc003xwt.2_Missense_Mutation_p.E456Q|SGK3_uc003xwu.2_Missense_Mutation_p.E424Q	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	456	AGC-kinase C-terminal.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATTTACAGAAGAAACAGTTCC	0.363		NA											36	72					0	0	0	0
ABRA	137735	broad.mit.edu	37	8	107782152	107782152	+	Silent	SNP	A	A	G			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:107782152A>G	uc003ymm.3	-	1	321	c.267T>C	c.(265-267)CAT>CAC	p.H89H		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	89					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GTCCATCTCCATGTCCTTCTG	0.532		NA											13	129					0	0	0	0
EPPK1	83481	broad.mit.edu	37	8	144940804	144940804	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:144940804C>T	uc003zaa.1	-	1	6631	c.6618G>A	c.(6616-6618)ACG>ACA	p.T2206T		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2206						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTCTTGCGTCGTGCTCCGTC	0.622		NA											49	196					0	0	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145724384	145724384	+	Missense_Mutation	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr8:145724384C>T	uc003zdd.2	+	4	1329	c.416C>T	c.(415-417)ACG>ATG	p.T139M	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Missense_Mutation_p.T139M	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	139	ANK 3.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GAGTGCTGGACGCCTCTGCAT	0.622		NA											10	49					0	0	0	0
DDX58	23586	broad.mit.edu	37	9	32488812	32488812	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr9:32488812C>T	uc003zra.2	-	7	1031	c.873G>A	c.(871-873)GGG>GGA	p.G291G	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Silent_p.G246G|DDX58_uc011lnr.1_Silent_p.G88G|DDX58_uc010mji.2_Silent_p.G220G	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	291	Helicase ATP-binding.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		AGACAACTTTCCCCTTTTGTC	0.338		NA											10	29					0	0	0	0
MAOA	4128	broad.mit.edu	37	X	43590580	43590580	+	Silent	SNP	C	C	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:43590580C>T	uc004dfy.2	+	7	919	c.738C>T	c.(736-738)CAC>CAT	p.H246H	MAOA_uc011mkw.1_Silent_p.H113H	NM_000240	NP_000231	P21397	AOFA_HUMAN	monoamine oxidase A	246	Cytoplasmic.				behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CTGTCACTCACGTTGACCAGT	0.453		NA											22	14					0	0	0	0
BCORL1	63035	broad.mit.edu	37	X	129147297	129147297	+	Silent	SNP	C	C	A			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:129147297C>A	uc004evb.1	+	4	663	c.549C>A	c.(547-549)GTC>GTA	p.V183V	BCORL1_uc010nrd.1_Silent_p.V85V	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	183					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GAACTGGAGTCCCTGTGGAGG	0.577		NA											9	30					0.000978159	0.00110043	1	0
NRD1	4898	broad.mit.edu	37	1	52256303	52256304	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:52256303_52256304insCC	uc001ctc.3	-	31	3595_3596	c.3273_3274insGG	c.(3271-3276)AAGCTGfs	p.K1091fs	NRD1_uc009vzb.2_Frame_Shift_Ins_p.K786fs|NRD1_uc001ctd.3_Frame_Shift_Ins_p.K1023fs|NRD1_uc001cte.2_Frame_Shift_Ins_p.K959fs	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	1022_1023					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						CACTCCTTCAGCTTGATGAGAG	0.545		NA											14	67	---	---	---	---	NA	NA	NA	NA
RBM15	64783	broad.mit.edu	37	1	110884597	110884598	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:110884597_110884598insT	uc001dzl.1	+	1	2653_2654	c.2570_2571insT	c.(2569-2571)TATfs	p.Y857fs	RBM15_uc001dzm.1_Frame_Shift_Ins_p.Y857fs|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	857	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCCAATGGTTATGCCATTCTTT	0.54		NA	T	MKL1	acute megakaryocytic leukemia								53	111	---	---	---	---	NA	NA	NA	NA
ZNF687	57592	broad.mit.edu	37	1	151261022	151261023	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr1:151261022_151261023insT	uc001exq.2	+	3	2232_2233	c.2134_2135insT	c.(2134-2136)ATGfs	p.M712fs	ZNF687_uc009wmo.2_Frame_Shift_Ins_p.M712fs|ZNF687_uc009wmp.2_Frame_Shift_Ins_p.M712fs	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	712	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AACCTGCCCCATGATGCTCCCC	0.574		NA											16	50	---	---	---	---	NA	NA	NA	NA
TPCN1	53373	broad.mit.edu	37	12	113704096	113704098	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr12:113704096_113704098delCTG	uc001tuw.2	+	4	646_648	c.349_351delCTG	c.(349-351)CTGdel	p.L122del	TPCN1_uc001tux.2_In_Frame_Del_p.L194del|TPCN1_uc010syt.1_In_Frame_Del_p.L54del	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	122	Helical; Name=S1 of repeat I; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						GGCCACGGCCCTGCTGCTGCTGC	0.64		NA											8	455	---	---	---	---	NA	NA	NA	NA
ZBTB25	7597	broad.mit.edu	37	14	64954345	64954345	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr14:64954345delA	uc001xhf.2	-	3	787	c.604delT	c.(604-606)TCCfs	p.S202fs	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Frame_Shift_Del_p.S202fs	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	202						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TGCTTGATGGAAACTGGGGGC	0.567		NA											61	221	---	---	---	---	NA	NA	NA	NA
TGOLN2	10618	broad.mit.edu	37	2	85554626	85554627	+	In_Frame_Ins	INS	-	-	GGT	rs76078295		TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chr2:85554626_85554627insGGT	uc010fgd.1	-	2	517_518	c.228_229insACC	c.(226-231)insACC	p.76_77insT	TGOLN2_uc002soz.2_In_Frame_Ins_p.76_77insT|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_In_Frame_Ins_p.76_77insT|TGOLN2_uc002spc.1_In_Frame_Ins_p.76_77insT	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	76_77	Extracellular (Potential).|14 X 14 AA tandem repeats.|2.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						GTGTCTTCTGGGGTCTGCGCCT	0.599		NA											33	300	---	---	---	---	NA	NA	NA	NA
USP9X	8239	broad.mit.edu	37	X	41088557	41088563	+	Frame_Shift_Del	DEL	CACAATC	CACAATC	-			TCGA-D6-6517-01A-11D-1870-08	TCGA-D6-6517-10A-01D-1870-08	 	 	 	 	 	 	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c553e4a2-cbea-43d6-8937-a48836856b5a	ee72db3d-dee6-4565-baa2-810612583853	g.chrX:41088557_41088563delCACAATC	uc004dfb.2	+	42	7746_7752	c.7113_7119delCACAATC	c.(7111-7119)GACACAATCfs	p.D2371fs	USP9X_uc004dfc.2_Frame_Shift_Del_p.D2371fs	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2371_2373					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GGCTGTTTGACACAATCCAGCGCTCTA	0.353		NA											5	5	---	---	---	---	NA	NA	NA	NA