Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANAPC4	29945	broad.mit.edu	37	4	25384881	25384881	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:25384881A>T	ENST00000315368.3	+	4	377		c.e4-1		ANAPC4_ENST00000510092.1_Splice_Site	NM_013367.2	NP_037499.2	Q9UJX5	APC4_HUMAN	anaphase promoting complex subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	27		Breast(46;0.0503)				TTCTTGTTTTAGTTTTGGCCT	0.343000													5	81					0	0	1	0	0
CRCP	27297	broad.mit.edu	37	7	65579857	65579857	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:65579857C>G	ENST00000431089.2	+	1	45	c.42C>G	c.(40-42)agC>agG	p.S14R	CRCP_ENST00000398684.2_5'UTR|CRCP_ENST00000395326.3_5'UTR|CRCP_ENST00000338592.5_5'UTR|AC068533.7_ENST00000450043.1_Intron	NM_001142414.1	NP_001135886.1	O75575	RPC9_HUMAN	CGRP receptor component	0					acrosome reaction|innate immune response|response to virus|transcription from RNA polymerase III promoter	DNA polymerase III complex|nucleus|plasma membrane	calcitonin receptor activity|DNA-directed RNA polymerase activity|nucleotide binding			cervix(1)|kidney(1)|lung(4)	6						GCGCGCGGAGCTGGCACCTTG	0.682000													38	42					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085464	9085464	+	Silent	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:9085464G>A	ENST00000397910.4	-	1	6554	c.6351C>T	c.(6349-6351)gcC>gcT	p.A2117A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2117	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGTACTCGCGGCTGTATTCT	0.488000													6	774					0	0	1	0	0
SAMD4B	55095	broad.mit.edu	37	19	39868378	39868378	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:39868378C>T	ENST00000314471.6	+	10	2393	c.1358C>T	c.(1357-1359)cCa>cTa	p.P453L	SAMD4B_ENST00000598913.1_Missense_Mutation_p.P453L|SAMD4B_ENST00000596368.1_Intron	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	453							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCACCAGCTCCAGCTCCCACT	0.657000													89	176					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9517301	9517301	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:9517301C>T	ENST00000402466.1	+	24	4329	c.3561C>T	c.(3559-3561)ccC>ccT	p.P1187P	SETD5_ENST00000406341.1_Silent_p.P1285P|SETD5_ENST00000402198.1_Silent_p.P1285P|SETD5_ENST00000407969.1_Silent_p.P1304P|SETD5_ENST00000302463.6_Silent_p.P1187P			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1285	Ser-rich.									NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		GAAACCCCCCCTCTCACGGTT	0.557000													4	447					0	0	1	0	0
UGT2A2	574537	broad.mit.edu	37	4	70505335	70505335	+	Silent	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:70505335G>A	ENST00000457664.2	-	1	23	c.24C>T	c.(22-24)acC>acT	p.T8T	UGT2A1_ENST00000503640.1_Intron|UGT2A1_ENST00000514019.1_Intron|UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000286604.4_Intron	NM_001105677.2	NP_001099147.2																					TCTTAGGCATGGTAAAATCCC	0.323000													5	163					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135426760	135426760	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chrX:135426760G>A	ENST00000394143.1	+	6	1186	c.895G>A	c.(895-897)Gca>Aca	p.A299T	GPR112_ENST00000412101.1_Missense_Mutation_p.A94T|GPR112_ENST00000394141.1_Missense_Mutation_p.A94T|GPR112_ENST00000370652.1_Missense_Mutation_p.A299T|GPR112_ENST00000287534.4_Missense_Mutation_p.A236T	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	299					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AACAATGACTGCACAAAAAAT	0.383000													5	698					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47583996	47583996	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:47583996C>T	ENST00000273859.3	+	21	3937	c.3668C>T	c.(3667-3669)aCt>aTt	p.T1223I	ATP10D_ENST00000512393.1_3'UTR	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1223					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GGCTCAGATACTGACATCTTT	0.458000													60	742					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137779023	137779023	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:137779023T>C	ENST00000350339.2	+	7	604	c.590T>C	c.(589-591)cTg>cCg	p.L197P	FCN2_ENST00000291744.6_Missense_Mutation_p.L235P	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	235	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		GGAGATTCCCTGACGTTCCAC	0.473000													4	226					0	0	1	0	0
FAM192A	80011	broad.mit.edu	37	16	57207783	57207783	+	Splice_Site	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:57207783T>A	ENST00000309137.8	-	2	244		c.e2-2		FAM192A_ENST00000389447.5_5'UTR|FAM192A_ENST00000567439.1_Splice_Site|FAM192A_ENST00000569266.1_Splice_Site|FAM192A_ENST00000564108.1_Splice_Site|FAM192A_ENST00000566077.1_Intron	NM_024946.2	NP_079222.1	Q9GZU8	F192A_HUMAN	family with sequence similarity 192, member A							nucleus				endometrium(2)|large_intestine(3)|lung(4)|prostate(2)	11						ACAACCAATCTACaaaacaaa	0.368000													6	369					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704333	52704333	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:52704333T>A	ENST00000287727.3	+	4	1416	c.1244T>A	c.(1243-1245)gTa>gAa	p.V415E	ZFYVE9_ENST00000361625.1_Missense_Mutation_p.V415E|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.V415E|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.V415E	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	415					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						GATAGCCAAGTAAACGAAGAA	0.398000													5	215					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2646841	2646841	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:2646841C>T	ENST00000402050.2	+	21	2133	c.1949C>T	c.(1948-1950)cCc>cTc	p.P650L	IQCE_ENST00000438376.2_Missense_Mutation_p.P634L|IQCE_ENST00000404984.1_Missense_Mutation_p.P599L|IQCE_ENST00000325979.7_Missense_Mutation_p.P585L	NM_001100390.1|NM_152558.3	NP_001093860.1|NP_689771.3	Q6IPM2	IQCE_HUMAN	IQ motif containing E	650										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		TCCTCCCCACCCTTCCTCGCA	0.552000													3	68					0	0	1	0	0
ANAPC4	29945	broad.mit.edu	37	4	25419775	25419775	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:25419775A>T	ENST00000315368.3	+	29	2341		c.e29-1		ANAPC4_ENST00000510092.1_Splice_Site	NM_013367.2	NP_037499.2	Q9UJX5	APC4_HUMAN	anaphase promoting complex subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	27		Breast(46;0.0503)				TTTCTTTTTTAGTTAAGCTCA	0.328000													10	318					0	0	1	0	0
GNPTAB	79158	broad.mit.edu	37	12	102158980	102158980	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:102158980G>C	ENST00000299314.7	-	13	1977	c.1715C>G	c.(1714-1716)gCc>gGc	p.A572G		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	572					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						TCCTCTTTTGGCTACTTCTGC	0.398000													7	375					0	0	1	0	0
SLC25A44	9673	broad.mit.edu	37	1	156170179	156170179	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:156170179G>A	ENST00000359511.4	+	2	713	c.541G>A	c.(541-543)Ggc>Agc	p.G181S	SLC25A44_ENST00000423538.2_Missense_Mutation_p.G158S|SLC25A44_ENST00000469537.1_3'UTR	NM_014655.2	NP_055470.1	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	181					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			breast(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Hepatocellular(266;0.158)					TGGACTTCGCGGCTTCTATCG	0.557000													4	267					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57140052	57140052	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:57140052A>T	ENST00000371244.4	+	2	160		c.e2-1			NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit						carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TCTTTTCTTTAGTTGGAGAAC	0.313000													4	116					0	0	1	0	0
ZNF443	10224	broad.mit.edu	37	19	12542199	12542199	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:12542199G>A	ENST00000301547.5	-	4	984	c.787C>T	c.(787-789)Cct>Tct	p.P263S	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	263					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						CTGTAAAAAGGAAAGGCTTTA	0.373000													5	880					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39090649	39090649	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:39090649A>T	ENST00000295373.6	-	3	363	c.237T>A	c.(235-237)agT>agA	p.S79R	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	79							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TGCTTATGTTACTGTTGCTAG	0.403000													5	305					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52850939	52850939	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:52850939G>A	ENST00000266041.4	-	21	2528	c.2432C>T	c.(2431-2433)gCg>gTg	p.A811V	ITIH4_ENST00000346281.5_Missense_Mutation_p.A795V|ITIH4_ENST00000485816.1_Missense_Mutation_p.A816V|ITIH4_ENST00000406595.1_Missense_Mutation_p.A781V	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	811					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CCACTTGTACGCAGAGCTTCT	0.577000													3	140					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797055	125797055	+	Silent	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:125797055T>C	ENST00000373642.1	+	1	250	c.210T>C	c.(208-210)acT>acC	p.T70T	RABGAP1_ENST00000373647.4_Intron|RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000493854.1_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	70						integral to plasma membrane	G-protein coupled receptor activity	p.T70T(1)		endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						TTATCCAGACTATGGCATATG	0.423000													3	115					0	0	1	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789895	140789895	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:140789895T>A	ENST00000520790.1	+	1	2126	c.2126T>A	c.(2125-2127)cTg>cAg	p.L709Q	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGTGATTCTGGCCATTGCC	0.587000													37	69					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33261380	33261380	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:33261380A>T	ENST00000334528.9	-	4	1852	c.1853T>A	c.(1852-1854)cTc>cAc	p.L618H	FMN1_ENST00000559047.1_Missense_Mutation_p.L841H|FMN1_ENST00000561249.1_Missense_Mutation_p.L743H	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	841	Mediates interaction with alpha-catenin (By similarity).|Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TGGGGGTGAGAGCTGGCTTAA	0.498000													11	408					0	0	1	0	0
C1QC	714	broad.mit.edu	37	1	22974251	22974251	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:22974251C>G	ENST00000374639.3	+	3	831	c.713C>G	c.(712-714)tCc>tGc	p.S238C	C1QC_ENST00000374640.4_Missense_Mutation_p.S238C|C1QC_ENST00000374637.1_Missense_Mutation_p.S238C	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	238	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGCGTCTTCTCCGGCTTCCTG	0.642000													25	102					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31332563	31332563	+	Splice_Site	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:31332563G>A	ENST00000544665.3	+	15	1783	c.1710_splice	c.e15-1	p.R571_splice	ITGAM_ENST00000287497.8_Splice_Site_p.R570_splice	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	570					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity	p.R570Q(1)		endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TACCCTCAGCGGATAGCAGGC	0.522000													5	550					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38692610	38692610	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:38692610C>T	ENST00000222345.6	+	20	5602	c.5093C>T	c.(5092-5094)cCg>cTg	p.P1698L		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1698					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGGGACCCCCGACCCCCAGG	0.647000													45	53					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35808752	35808752	+	Splice_Site	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:35808752G>A	ENST00000342694.2	+	20	3143	c.2887_splice	c.e20-1	p.G963_splice	SPAG8_ENST00000340291.2_Intron	NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	963	Guanylate cyclase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CTTCTCAAAGGGCCAGTCTGT	0.522000													4	231					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													4	491					0	0	1	0	0
C9orf9	11092	broad.mit.edu	37	9	135759453	135759453	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:135759453T>C	ENST00000372136.3	+	2	566	c.119T>C	c.(118-120)aTc>aCc	p.I40T	C9orf9_ENST00000356311.5_Missense_Mutation_p.I40T|C9orf9_ENST00000350499.6_Missense_Mutation_p.I40T			Q96E40	CI009_HUMAN	chromosome 9 open reading frame 9	40								p.?(1)		cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		CACGACAAGATCCGGCCCATC	0.627000													5	98					0	0	1	0	0
KRTAP4-12	83755	broad.mit.edu	37	17	39280266	39280266	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:39280266G>A	ENST00000394014.1	-	1	153	c.109C>T	c.(109-111)Cgc>Tgc	p.R37C		NM_031854.2	NP_114060.1	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	37	31 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]- [VSTQPC].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CAGCTGGGGCGGCAGCAGGTG	0.672000													5	62					0	0	1	0	0
CTDSPL2	51496	broad.mit.edu	37	15	44751187	44751187	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:44751187A>T	ENST00000260327.4	+	2	539		c.e2-1		CTDSPL2_ENST00000558966.1_Splice_Site|CTDSPL2_ENST00000396780.1_Splice_Site	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2								phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		tttCTCTTTTAGTTTTACATG	0.343000													5	92					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39879325	39879325	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:39879325C>T	ENST00000530275.1	+	1	3175	c.2980C>T	c.(2980-2982)Ccc>Tcc	p.P994S	MACF1_ENST00000289893.4_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000567887.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000372915.3_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	994	Ala-rich.									central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCCAGAGGAGCCCGCCTCCCC	0.706000													3	4					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45375310	45375310	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:45375310C>T	ENST00000252483.5	+	3	679	c.679C>T	c.(679-681)Ccc>Tcc	p.P227S	PVRL2_ENST00000252485.4_Missense_Mutation_p.P227S	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	227	Ig-like C2-type 1.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CACCTTGGTGCCCTCGGGCCG	0.597000													5	430					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50025308	50025308	+	Missense_Mutation	SNP	C	C	T	rs149751647		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:50025308C>T	ENST00000261897.1	+	2	676	c.125C>T	c.(124-126)gCg>gTg	p.A42V	PRPF40B_ENST00000380281.1_Missense_Mutation_p.A48V|PRPF40B_ENST00000548825.2_Missense_Mutation_p.A70V			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	48	Pro-rich.				mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CCAATGGGGGCGCCACCACCA	0.612000													19	172					0	0	1	0	0
OR6C3	254786	broad.mit.edu	37	12	55725568	55725568	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:55725568A>T	ENST00000379667.1	+	1	84	c.84A>T	c.(82-84)ttA>ttT	p.L28F		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						TTCTCTTTTTATTTATCACGT	0.423000													7	395					0	0	1	0	0
PPP3CA	5530	broad.mit.edu	37	4	102015074	102015074	+	Splice_Site	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:102015074T>A	ENST00000394854.3	-	6	1326		c.e6-2		PPP3CA_ENST00000394853.4_Splice_Site|PPP3CA_ENST00000523694.2_Splice_Site|PPP3CA_ENST00000512215.1_Intron|PPP3CA_ENST00000510292.1_Splice_Site|PPP3CA_ENST00000507176.1_Splice_Site|PPP3CA_ENST00000323055.6_Splice_Site	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme						protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		TCGGTCTAACTAAGAAAAATA	0.408000													5	253					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61566560	61566560	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:61566560T>A	ENST00000398571.2	-	18	2746	c.2670A>T	c.(2668-2670)ttA>ttT	p.L890F		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	890					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			ACCAACATACTAACGAACAAA	0.279000													4	69					0	0	1	0	0
MPZL3	196264	broad.mit.edu	37	11	118111081	118111081	+	Missense_Mutation	SNP	C	C	T	rs140506520	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:118111081C>T	ENST00000278949.4	-	2	140	c.85G>A	c.(85-87)Gtc>Atc	p.V29I	MPZL3_ENST00000527472.1_Intron|MPZL3_ENST00000525386.1_Intron			Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3	29					cell adhesion	integral to membrane		p.V29I(1)		autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		AAGGAAAAGACGATATAAACA	0.388000													4	378					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74440152	74440152	+	Missense_Mutation	SNP	G	G	A	rs111900767		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:74440152G>A	ENST00000437994.2	+	4	793	c.362G>A	c.(361-363)cGc>cAc	p.R121H	CD109_ENST00000422508.2_Intron|CD109_ENST00000287097.5_Missense_Mutation_p.R121H	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	121						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AATAGTACCCGCTTATCATTT	0.418000													60	22					0	0	1	0	0
USP39	10713	broad.mit.edu	37	2	85863199	85863199	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:85863199T>C	ENST00000323701.6	+	7	983	c.973T>C	c.(973-975)Tgg>Cgg	p.W325R	USP39_ENST00000409025.1_Missense_Mutation_p.W325R|USP39_ENST00000450066.2_Missense_Mutation_p.W222R|USP39_ENST00000409766.3_Missense_Mutation_p.W325R|USP39_ENST00000459775.1_3'UTR|USP39_ENST00000409470.1_Missense_Mutation_p.W325R	NM_006590.3	NP_006581.2	Q53GS9	SNUT2_HUMAN	ubiquitin specific peptidase 39	325					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	19						CTTTCTGTCTTGGTTTCTGAA	0.398000													4	533					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9015723	9015723	+	Silent	SNP	C	C	T	rs144233170	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:9015723C>T	ENST00000397910.4	-	29	38303	c.38100G>A	c.(38098-38100)ccG>ccA	p.P12700P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12702	SEA 5.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGGGTGAACGGCACCAGGA	0.468000													10	1906					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350458	100350458	+	RNA	SNP	A	A	G	rs111855792		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:100350458A>G	ENST00000542585.1	+	0	2878				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCATCTCCCCAGAAAAACCCA	0.507000													3	29					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53876678	53876678	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:53876678G>A	ENST00000267079.2	-	12	2035	c.1810C>T	c.(1810-1812)Cgc>Tgc	p.R604C	MAP3K12_ENST00000547488.1_Missense_Mutation_p.R637C|MAP3K12_ENST00000547035.1_Missense_Mutation_p.R637C	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	604					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						GACATTTTGCGGAGCAGGAGG	0.687000													3	182					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281389	152281389	+	Silent	SNP	C	C	T	rs138652718	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:152281389C>T	ENST00000368799.1	-	3	6008	c.5973G>A	c.(5971-5973)gcG>gcA	p.A1991A	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1991	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGGATGACGCAGCCTGTC	0.572000									Ichthyosis				9	874					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8399610	8399610	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:8399610A>G	ENST00000471889.1	+	8	2217	c.1832A>G	c.(1831-1833)tAt>tGt	p.Y611C	SLC45A1_ENST00000289877.8_Missense_Mutation_p.Y611C|SLC45A1_ENST00000377479.2_Missense_Mutation_p.Y645C			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	611					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TTCATCGCCTATCTCGCCTTC	0.607000													64	27					0	0	1	0	0
PSMD4	5710	broad.mit.edu	37	1	151237916	151237916	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:151237916G>A	ENST00000368884.3	+	6	565	c.485G>A	c.(484-486)gGc>gAc	p.G162D	PSMD4_ENST00000368881.4_Missense_Mutation_p.G162D	NM_002810.2	NP_002801.1	P55036	PSMD4_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	162	VWFA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|lung(7)	11	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACGTTGAATGGCAAAGATGGA	0.517000													4	217					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76380267	76380267	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:76380267A>T	ENST00000370014.3	+	11	1843		c.e11-1		SENP6_ENST00000327284.8_Splice_Site|SENP6_ENST00000370010.2_Splice_Site|SENP6_ENST00000447266.2_Splice_Site|SENP6_ENST00000541192.1_Splice_Site	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6						proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				TTTCCTTTTTAGTTTGGCAAT	0.323000													5	86					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36162173	36162173	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:36162173C>T	ENST00000303965.4	-	13	2839	c.2350G>A	c.(2350-2352)Gaa>Aaa	p.E784K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	784	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTTCTCTTTTCTACTGGTGAG	0.308000													3	39					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25310247	25310247	+	RNA	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:25310247A>G	ENST00000549804.2	+	0	538				SNORD116-6_ENST00000384711.1_RNA|SNHG14_ENST00000551077.1_RNA																							TCATACCGTCATTCTCATCGG	0.453000													5	508					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224344	248224344	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:248224344C>T	ENST00000359959.3	+	1	361	c.361C>T	c.(361-363)Cgt>Tgt	p.R121C	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GGCCTATGATCGTTACATTGC	0.443000													5	422					0	0	1	0	0
GUF1	60558	broad.mit.edu	37	4	44696427	44696427	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:44696427A>T	ENST00000281543.5	+	14	1807		c.e14-1		GUF1_ENST00000506793.1_Splice_Site	NM_021927.2	NP_068746.2	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog (S. cerevisiae)						translation	mitochondrial inner membrane	GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19						TTTTCCTTTTAGTTTTGATTA	0.343000													4	72					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135740822	135740822	+	Nonsense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:135740822C>T	ENST00000392915.1	-	9	3472	c.3353G>A	c.(3352-3354)tGg>tAg	p.W1118*	MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000375845.3_Intron|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000358371.4_Intron|MAP3K19_ENST00000315513.3_5'UTR					mitogen-activated protein kinase kinase kinase 19																		TTGTTTTTGCCATCTAGTAAT	0.413000													3	157					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159156	18159156	+	Missense_Mutation	SNP	G	G	A	rs146036416		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:18159156G>A	ENST00000396275.2	+	3	768	c.407G>A	c.(406-408)aGa>aAa	p.R136K		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	136						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CGCCGCCCCAGATACCTGTCA	0.567000													5	137					0	0	1	0	0
SERTAD3	29946	broad.mit.edu	37	19	40947607	40947607	+	Silent	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:40947607G>A	ENST00000322354.3	-	2	877	c.381C>T	c.(379-381)ccC>ccT	p.P127P	SERTAD3_ENST00000392028.4_Silent_p.P127P	NM_203344.2	NP_976219.1	Q9UJW9	SRTD3_HUMAN	SERTA domain containing 3	127					negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(4)|lung(2)	7			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GATCAGGCTGGGGTGGCACTT	0.557000													4	392					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182400218	182400218	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:182400218T>A	ENST00000397033.2	+	28	3493	c.3063T>A	c.(3061-3063)agT>agA	p.S1021R		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	1021					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAAGAGACAGTTGGAGTTATA	0.313000													4	282					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7797351	7797351	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:7797351G>A	ENST00000303635.7	+	15	3586	c.3379G>A	c.(3379-3381)Gtc>Atc	p.V1127I	CAMTA1_ENST00000439411.2_Missense_Mutation_p.V1127I	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GGAAGCTGCCGTCGTGCTGTA	0.557000			T	WWTR1	epitheliod hemangioendothelioma								4	119					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76885765	76885765	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:76885765A>G	ENST00000285871.4	+	6	750	c.623A>G	c.(622-624)aAg>aGg	p.K208R	CCDC146_ENST00000431197.1_5'UTR|AC073635.5_ENST00000476561.2_RNA	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	208										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TCTAAACAAAAGCAATTATTA	0.323000													6	402					0	0	1	0	0
IFT74	80173	broad.mit.edu	37	9	26988665	26988665	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:26988665A>T	ENST00000443698.1	+	7	636		c.e7-1		IFT74_ENST00000429045.2_Splice_Site|IFT74_ENST00000380062.5_Splice_Site|IFT74_ENST00000433700.1_Splice_Site	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)							cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TTTTGTTTTTAGTTGGTAGAT	0.254000													4	27					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42492233	42492233	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:42492233G>A	ENST00000545399.1	-	4	404	c.251C>T	c.(250-252)aCg>aTg	p.T84M	ATP1A3_ENST00000543770.1_Missense_Mutation_p.T82M|ATP1A3_ENST00000602133.1_Missense_Mutation_p.T41M|ATP1A3_ENST00000468774.2_5'UTR|ATP1A3_ENST00000302102.5_Missense_Mutation_p.T71M	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	71					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						AGGCGGTGGCGTGAGTGCGTT	0.632000													141	215					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37620095	37620095	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:37620095A>T	ENST00000252011.3	+	6	483		c.e6-1		DHX35_ENST00000373323.4_Splice_Site|DHX35_ENST00000373325.2_Splice_Site	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35							catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				TTTATTTTTTAGTTTCTTACT	0.313000													7	211					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18173055	18173055	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:18173055C>T	ENST00000600835.1	-	15	1954	c.1651G>A	c.(1651-1653)Gcc>Acc	p.A551T	IL12RB1_ENST00000593993.1_Missense_Mutation_p.A551T|IL12RB1_ENST00000430026.2_Missense_Mutation_p.A551T			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	551					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCCAGGGAGGCGAAGAAGATG	0.572000													21	325					0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24854824	24854824	+	Splice_Site	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:24854824T>A	ENST00000313367.2	-	19	2479		c.e19-2		OSBPL3_ENST00000352860.1_Splice_Site|OSBPL3_ENST00000353930.1_Splice_Site|OSBPL3_ENST00000396429.1_Splice_Site|OSBPL3_ENST00000431825.2_Splice_Site|OSBPL3_ENST00000396431.1_Splice_Site|OSBPL3_ENST00000409069.1_Splice_Site	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3						lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						TCCCCAAAACTAAAAAGAAGG	0.378000													10	258					0	0	1	0	0
OR10A2	341276	broad.mit.edu	37	11	6891808	6891808	+	Missense_Mutation	SNP	A	A	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:6891808A>C	ENST00000307322.4	+	1	885	c.823A>C	c.(823-825)Att>Ctt	p.I275L		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GTTGAACCCCATTATCTACAG	0.468000													4	290					0	0	1	0	0
MRPL2	51069	broad.mit.edu	37	6	43023724	43023724	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:43023724G>A	ENST00000388752.3	-	5	966	c.542C>T	c.(541-543)gCg>gTg	p.A181V	MRPL2_ENST00000489623.1_Intron|MRPL2_ENST00000230413.5_Missense_Mutation_p.A181V	NM_015950.3	NP_057034.2	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2	181					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(2)	9		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		AAGAGGATGCGCATCCCCTTC	0.552000													3	73					0	0	1	0	0
ZMAT2	153527	broad.mit.edu	37	5	140083501	140083501	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:140083501A>T	ENST00000274712.3	+	4	363		c.e4-1			NM_144723.1	NP_653324.1	Q96NC0	ZMAT2_HUMAN	zinc finger, matrin-type 2							nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(1)|liver(1)|lung(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTCCTGTTAGATATTACTG	0.368000													6	499					0	0	1	0	0
TAF7	6879	broad.mit.edu	37	5	140699180	140699180	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:140699180C>T	ENST00000313368.5	-	1	1150	c.432G>A	c.(430-432)agG>agA	p.R144R		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	144					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTTCTCTTCCTGACATTCT	0.388000													5	157					0	0	1	0	0
WDR27	253769	broad.mit.edu	37	6	170033136	170033136	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:170033136C>A	ENST00000333572.6	-	21	2649	c.2130G>T	c.(2128-2130)agG>agT	p.R710S	WDR27_ENST00000448612.1_Missense_Mutation_p.R710S|WDR27_ENST00000423258.1_Missense_Mutation_p.R583S|WDR27_ENST00000546525.1_5'UTR			A2RRH5	WDR27_HUMAN	WD repeat domain 27	680										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		CTTCCACGGTCCTGTTCCGGC	0.532000													22	12					1.66031e-10	1.77415e-10	1	1	0
MUC16	94025	broad.mit.edu	37	19	9065630	9065630	+	Silent	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:9065630A>T	ENST00000397910.4	-	3	22019	c.21816T>A	c.(21814-21816)atT>atA	p.I7272I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7274	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGTAGCACCAATGGACACTT	0.488000													7	765					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55523710	55523710	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:55523710G>A	ENST00000219070.4	+	7	1663	c.1154G>A	c.(1153-1155)cGc>cAc	p.R385H	MMP2_ENST00000543485.1_Missense_Mutation_p.R309H|MMP2_ENST00000437642.2_Missense_Mutation_p.R335H|MMP2_ENST00000570308.1_Missense_Mutation_p.R309H	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	385	Collagen-binding.|Fibronectin type-II 3.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GATGATGACCGCAAGTGGGGC	0.567000													4	182					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89084114	89084114	+	RNA	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:89084114G>A	ENST00000393525.3	+	0	576																											TTGCTTTTCAGTGTCTTCTCA	0.313000													5	138					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51308360	51308360	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:51308360C>A	ENST00000266037.9	+	24	2493	c.2470C>A	c.(2470-2472)Cac>Aac	p.H824N		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	824						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGCACTGTGCACATTGGGCA	0.512000													6	208					0.00116845	0.00119399	1	1	0
NHEJ1	79840	broad.mit.edu	37	2	220022916	220022916	+	Nonsense_Mutation	SNP	G	G	A	rs118204451		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:220022916G>A	ENST00000356853.5	-	2	302	c.169C>T	c.(169-171)Cga>Tga	p.R57*	NHEJ1_ENST00000409720.1_Nonsense_Mutation_p.R57*	NM_024782.2	NP_079058.1	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	57			R -> G (in NHEJ1-SCID; fails to translocate to the nucleus).		B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(2)	12		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		ACCTTGGCTCGCTGGCTGACC	0.507000								Non-homologous end-joining					4	438					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197544159	197544159	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:197544159C>A	ENST00000438796.2	+	3	564	c.520C>A	c.(520-522)Cat>Aat	p.H174N	LRCH3_ENST00000414675.2_Missense_Mutation_p.H174N|LRCH3_ENST00000334859.4_Missense_Mutation_p.H174N|LRCH3_ENST00000425562.2_Missense_Mutation_p.H174N|LRCH3_ENST00000441090.2_Intron			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	174						extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		ACACCTTAGACATTTGATGGA	0.338000													4	174					1	1	1	1	0
TAF1L	138474	broad.mit.edu	37	9	32631342	32631342	+	Silent	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:32631342G>A	ENST00000242310.4	-	1	4325	c.4236C>T	c.(4234-4236)atC>atT	p.I1412I		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1412					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCATGTCATTGATGATAGACT	0.458000													8	1163					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109740267	109740267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:109740267C>T	ENST00000369939.3	+	16	2476	c.2293C>T	c.(2293-2295)Cga>Tga	p.R765*	KIAA1324_ENST00000529753.1_Nonsense_Mutation_p.R678*|KIAA1324_ENST00000369938.1_3'UTR	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	765					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CCTTGCTGATCGACTTATTGG	0.527000													6	28					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10523064	10523064	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:10523064C>T	ENST00000444303.2	+	11	1764	c.1292C>T	c.(1291-1293)gCc>gTc	p.A431V	AMPD3_ENST00000396554.3_Missense_Mutation_p.A599V|AMPD3_ENST00000530864.1_3'UTR	NM_001172431.1	NP_001165902.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	590					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		TGTGGGGAAGCCGGCTCCATC	0.627000													3	66					0	0	1	0	0
FTSJ3	117246	broad.mit.edu	37	17	61897195	61897195	+	Silent	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:61897195A>T	ENST00000427159.2	-	21	3156	c.2511T>A	c.(2509-2511)cgT>cgA	p.R837R		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	837					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						TTTGTTCCTTACGTTGCTGTG	0.537000													8	614					0	0	1	0	0
HPS3	84343	broad.mit.edu	37	3	148872892	148872892	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:148872892A>T	ENST00000296051.2	+	8	1540		c.e8-1		HPS3_ENST00000460120.1_Splice_Site	NM_032383.3	NP_115759.2	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3							cytoplasm				breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	34			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TTTTGCTTTTAGTTCGAGAAA	0.303000									Hermansky-Pudlak syndrome				4	218					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49377656	49377656	+	Nonsense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:49377656G>A	ENST00000200453.5	+	2	1435	c.1166G>A	c.(1165-1167)tGg>tAg	p.W389*		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	389	4 X 34 AA approximate repeats.|Glu-rich.|Interaction with SMAD7.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		TTGAAGTCCTGGGTCTATCAG	0.517000													7	804					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169510502	169510502	+	Missense_Mutation	SNP	G	G	T	rs140018525	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:169510502G>T	ENST00000367796.3	-	13	4042	c.3841C>A	c.(3841-3843)Ctt>Att	p.L1281I	F5_ENST00000367797.3_Missense_Mutation_p.L1276I			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1276	35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCTGGAGAAAGGGGCATCTGA	0.502000													5	563					2.7689e-08	2.94195e-08	1	1	0
IGSF10	285313	broad.mit.edu	37	3	151164958	151164958	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:151164958A>T	ENST00000282466.3	-	4	2810	c.2811T>A	c.(2809-2811)agT>agA	p.S937R		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	937					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGGTGGTGCTACTAAGCATTT	0.398000													8	1190					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74270115	74270115	+	Missense_Mutation	SNP	G	G	A	rs74821926		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:74270115G>A	ENST00000295897.4	+	1	160	c.71G>A	c.(70-72)cGa>cAa	p.R24Q	ALB_ENST00000503124.1_5'UTR|ALB_ENST00000509063.1_Missense_Mutation_p.R24Q|ALB_ENST00000401494.3_Missense_Mutation_p.R24Q|ALB_ENST00000415165.2_Missense_Mutation_p.R24Q	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	24	Albumin 1.		R -> L (in Jaffna).|R -> P (in Takefu/Honolulu-1).|R -> Q (in Christchurch/Honolulu-2).		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GTGTTTCGTCGAGATGCACGT	0.363000													74	110					0	0	1	0	0
ETFDH	2110	broad.mit.edu	37	4	159618720	159618720	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:159618720A>T	ENST00000511912.1	+	8	1173	c.841A>T	c.(841-843)Att>Ttt	p.I281F	ETFDH_ENST00000307738.5_Missense_Mutation_p.I234F	NM_004453.2	NP_004444.2	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	281					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|prostate(1)|skin(3)	28	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		GTTATGGGTTATTGATGAAAA	0.353000													6	186					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397811	125397811	+	Silent	SNP	C	C	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:125397811C>A	ENST00000536769.1	-	1	2083	c.507G>T	c.(505-507)gtG>gtT	p.V169V	UBC_ENST00000538617.1_Intron|UBC_ENST00000339647.5_Silent_p.V169V|UBC_ENST00000546120.1_Intron			P0CG48	UBC_HUMAN	ubiquitin C	169	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CACTGGGCTCCACCTCGAGGG	0.522000													4	410					0.0477658	0.0482821	1	1	0
MON2	23041	broad.mit.edu	37	12	62928623	62928623	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:62928623A>T	ENST00000393630.3	+	13	2024		c.e13-1		MON2_ENST00000280379.6_Splice_Site|MON2_ENST00000552738.1_Splice_Site|MON2_ENST00000552115.1_Splice_Site|MON2_ENST00000393632.2_Splice_Site|MON2_ENST00000393629.2_Splice_Site|MON2_ENST00000546600.1_Splice_Site	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)						Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTTTCCTTTAAGTTAGTAGGG	0.323000													4	196					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47886683	47886683	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:47886683C>A	ENST00000396105.1	-	3	1912	c.1666G>T	c.(1666-1668)Gac>Tac	p.D556Y	ZNFX1_ENST00000371752.1_Missense_Mutation_p.D556Y|ZNFX1_ENST00000371754.4_Missense_Mutation_p.D556Y	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	556							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGGGTAAAGTCGTATCTGCCC	0.478000													15	266					2.23348e-06	2.3333e-06	1	1	0
OR6Q1	219952	broad.mit.edu	37	11	57798663	57798663	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:57798663T>G	ENST00000302622.3	+	1	262	c.239T>G	c.(238-240)gTg>gGg	p.V80G	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				TCTGTTACAGTGCCCAAGATG	0.473000													221	187					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214170345	214170345	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:214170345G>A	ENST00000366958.4	+	2	1075	c.467G>A	c.(466-468)cGc>cAc	p.R156H	PROX1_ENST00000498508.2_Missense_Mutation_p.R156H|PROX1_ENST00000435016.1_Missense_Mutation_p.R156H|PROX1_ENST00000261454.4_Missense_Mutation_p.R156H	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	156					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GATATGGATCGCTTATGTGAT	0.498000													27	177					0	0	1	0	0
FABP1	2168	broad.mit.edu	37	2	88425818	88425818	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:88425818C>T	ENST00000393750.3	-	2	148	c.117G>A	c.(115-117)tcG>tcA	p.S39S	FABP1_ENST00000295834.3_Silent_p.S39S|FABP1_ENST00000495375.1_5'UTR			P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	39					organ morphogenesis					kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	6						GCACGATTTCCGACACCCCCT	0.527000													6	751					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807460	20807460	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:20807460T>C	ENST00000601440.1	-	4	1369	c.1223A>G	c.(1222-1224)tAc>tGc	p.Y408C	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Y408C(1)		breast(1)|endometrium(1)|lung(3)|skin(1)	6						GTTAGAGGAGTACTTAAAAGC	0.408000													4	189					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56345006	56345006	+	Silent	SNP	A	A	G	rs145553253	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:56345006A>G	ENST00000526812.2	-	1	257	c.192T>C	c.(190-192)ggT>ggC	p.G64G		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						AGGAGAGGTGACCAAGGAAGA	0.463000													4	144					0	0	1	0	0
SUOX	6821	broad.mit.edu	37	12	56398608	56398608	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:56398608G>C	ENST00000394109.3	+	3	2159	c.1435G>C	c.(1435-1437)Gaa>Caa	p.E479Q	SUOX_ENST00000356124.4_Missense_Mutation_p.E479Q|SUOX_ENST00000548274.1_Missense_Mutation_p.E479Q|SUOX_ENST00000394115.2_Missense_Mutation_p.E479Q|SUOX_ENST00000266971.3_Missense_Mutation_p.E479Q			P51687	SUOX_HUMAN	sulfite oxidase	479	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GGATGGAGAGGAACAGCGCCC	0.587000													3	144					0	0	1	0	0
SLC30A9	10463	broad.mit.edu	37	4	42022431	42022431	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:42022431A>T	ENST00000264451.6	+	4	514		c.e4-1			NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TTTTTTGTTTAGTTAAAGCAG	0.348000													9	179					0	0	1	0	0
WIF1	11197	broad.mit.edu	37	12	65462686	65462686	+	Splice_Site	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:65462686T>A	ENST00000286574.4	-	4	772		c.e4-2			NM_007191.4	NP_009122.2	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1						multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			cervix(1)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	21			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		CTTGAACAACTAAAAGAAAAA	0.373000			T	HMGA2	pleomorphic salivary gland adenoma								5	110					0	0	1	0	0
GTF3C2	2976	broad.mit.edu	37	2	27559290	27559290	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:27559290A>G	ENST00000359541.2	-	8	1559	c.1130T>C	c.(1129-1131)tTt>tCt	p.F377S	AC109828.1_ENST00000592265.1_RNA|AC109828.1_ENST00000416453.2_RNA|GTF3C2_ENST00000264720.3_Missense_Mutation_p.F377S|AC109828.1_ENST00000585326.1_RNA			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	377						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATCGAGCTAAATCTAGAGAA	0.532000													26	67					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91369271	91369271	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:91369271G>A	ENST00000261991.3	-	9	1173	c.1000C>T	c.(1000-1002)Cca>Tca	p.P334S	RPS6KA5_ENST00000418736.2_Missense_Mutation_p.P334S|RPS6KA5_ENST00000536315.2_Missense_Mutation_p.P255S	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	334	AGC-kinase C-terminal.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		GGCTTAAATGGTGCAGGCACT	0.393000													4	176					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102530659	102530659	+	Silent	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:102530659T>C	ENST00000321521.9	+	29	4062	c.3489T>C	c.(3487-3489)taT>taC	p.Y1163Y	PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Silent_p.Y1184Y|PPIP5K2_ENST00000414217.1_Silent_p.Y1163Y			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	1184					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TAAATACGTATACACCTGCAA	0.373000													3	81					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345068	20345068	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:20345068A>T	ENST00000298642.2	+	1	678	c.642A>T	c.(640-642)ttA>ttT	p.L214F		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTATTGTTTTATTTAATTCAT	0.388000													5	453					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37770867	37770867	+	Silent	SNP	G	G	A	rs149957183		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:37770867G>A	ENST00000402918.1	-	3	1493	c.708C>T	c.(706-708)aaC>aaT	p.N236N	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Silent_p.N236N	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	236	LRRCT.					cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					CGGTGATGGCGTTGAGGCTGT	0.677000													7	4					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235866217	235866217	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:235866217T>C	ENST00000389794.3	-	45	10378	c.10204A>G	c.(10204-10206)Acc>Gcc	p.T3402A	LYST_ENST00000389793.2_Missense_Mutation_p.T3402A|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3402	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTATCATGGTTTCTAGCGCT	0.473000													3	249					0	0	1	0	0
PREP	5550	broad.mit.edu	37	6	105800954	105800954	+	Splice_Site	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:105800954T>A	ENST00000369110.3	-	7	910		c.e7-2			NM_002726.4	NP_002717.3	P48147	PPCE_HUMAN	prolyl endopeptidase						proteolysis		serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ATCAGATAACTAAAAAAGAAA	0.343000													6	106					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	131007746	131007746	+	Silent	SNP	A	A	T	rs75277328	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:131007746A>T	ENST00000307968.7	-	13	2306	c.2307T>A	c.(2305-2307)acT>acA	p.T769T	FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000307954.8_Silent_p.T752T|FNIP1_ENST00000510461.1_Silent_p.T797T	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TTGTTTGTTTAGTTTCTTGAT	0.443000													7	580					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25565566	25565566	+	Missense_Mutation	SNP	G	G	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr18:25565566G>C	ENST00000269141.3	-	12	2324	c.1901C>G	c.(1900-1902)gCt>gGt	p.A634G	CDH2_ENST00000399380.3_Missense_Mutation_p.A603G	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	634	Cadherin 5.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						AAATGGTCCAGCATTTGGATC	0.383000													4	230					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117261597	117261597	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:117261597G>A	ENST00000278935.3	+	16	2186	c.2039G>A	c.(2038-2040)aGc>aAc	p.S680N	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	680	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GTCCAGTCCAGCACACAAGCA	0.602000													4	85					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67576514	67576514	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:67576514A>G	ENST00000540839.3	+	14	2105	c.1885A>G	c.(1885-1887)Acc>Gcc	p.T629A	CTD-2012K14.3_ENST00000563083.1_RNA|FAM65A_ENST00000428437.2_Missense_Mutation_p.T623A|FAM65A_ENST00000379312.3_Missense_Mutation_p.T613A|FAM65A_ENST00000042381.4_Missense_Mutation_p.T609A|FAM65A_ENST00000422602.2_Missense_Mutation_p.T629A			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	613	Pro-rich.					cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GCCAAGCCCTACCCATACCAC	0.542000													5	423					0	0	1	0	0
F2	2147	broad.mit.edu	37	11	46760614	46760614	+	Silent	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:46760614A>G	ENST00000311907.5	+	13	1727	c.1671A>G	c.(1669-1671)gaA>gaG	p.E557E	F2_ENST00000530231.1_Silent_p.E518E	NM_000506.3	NP_000497.1	P00734	THRB_HUMAN	coagulation factor II (thrombin)	557	High affinity receptor-binding region which is also known as the TP508 peptide.|Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity	p.E557E(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	27		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	AGCCTGATGAAGGGAAACGAG	0.552000													3	207					0	0	1	0	0
FBXO4	26272	broad.mit.edu	37	5	41934293	41934293	+	Nonsense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:41934293C>T	ENST00000296812.2	+	5	837	c.781C>T	c.(781-783)Cga>Tga	p.R261*	FBXO4_ENST00000509134.1_Nonsense_Mutation_p.R261*|FBXO4_ENST00000281623.3_Nonsense_Mutation_p.R261*	NM_033484.2	NP_277019.1	Q9UKT5	FBX4_HUMAN	F-box protein 4	261					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(11)|prostate(1)|stomach(1)|urinary_tract(2)	27		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				GATGTTCAGTCGACACAATGA	0.368000													4	216					0	0	1	0	0
CTSO	1519	broad.mit.edu	37	4	156850793	156850793	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:156850793C>T	ENST00000433477.3	-	6	808	c.739G>A	c.(739-741)Gca>Aca	p.A247T		NM_001334.2	NP_001325.1	P43234	CATO_HUMAN	cathepsin O	247					proteolysis	lysosome	cysteine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|prostate(1)	16	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		CAGCTCACTGCATCTACTATG	0.403000													4	233					0	0	1	0	0
DCAF17	80067	broad.mit.edu	37	2	172314880	172314880	+	Splice_Site	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:172314880A>T	ENST00000375255.3	+	8	1059		c.e8-1		DCAF17_ENST00000539783.1_Splice_Site|DCAF17_ENST00000468592.1_Intron	NM_025000.3	NP_079276.2	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17							CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus				endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)	17						TTTTGTTTTTAGTTCATGCAA	0.358000													4	149					0	0	1	0	0
ZNF259	8882	broad.mit.edu	37	11	116652913	116652913	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:116652913C>G	ENST00000227322.3	-	12	1199	c.1140G>C	c.(1138-1140)caG>caC	p.Q380H		NM_003904.3	NP_003895.1	O75312	ZPR1_HUMAN	zinc finger protein 259	380					cell proliferation|signal transduction	cytoplasm|nucleolus				breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		GTCTCTCCGTCTGTCCAGGAT	0.468000													4	75					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009704	9009704	+	Missense_Mutation	SNP	G	G	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:9009704G>T	ENST00000397910.4	-	39	39225	c.39022C>A	c.(39022-39024)Cct>Act	p.P13008T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13010					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACCAGGAGAGGAACAGCTGCT	0.448000													10	1556					2.17888e-05	2.25111e-05	1	1	0
C2orf44	80304	broad.mit.edu	37	2	24260997	24260997	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:24260997A>T	ENST00000295148.4	-	2	1425	c.1368T>A	c.(1366-1368)aaT>aaA	p.N456K	C2orf44_ENST00000406895.3_Missense_Mutation_p.N456K	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	456							protein binding		C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATTTGCTTTATTTAACGGAG	0.363000			T	ALK	NSCLC								5	172					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25310233	25310233	+	RNA	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:25310233A>G	ENST00000549804.2	+	0	538				SNORD116-6_ENST00000384711.1_RNA|SNHG14_ENST00000551077.1_RNA																							AAATGAGTGAAAACTCATACC	0.453000													5	516					0	0	1	0	0
RAVER2	55225	broad.mit.edu	37	1	65243530	65243530	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:65243530C>T	ENST00000294428.3	+	3	619	c.541C>T	c.(541-543)Cat>Tat	p.H181Y	RAVER2_ENST00000371072.4_Missense_Mutation_p.H181Y			Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	181	RRM 2.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						AGTTACTGGCCATTCCAAAGG	0.413000													8	1084					0	0	1	0	0
A4GNT	51146	broad.mit.edu	37	3	137849767	137849767	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:137849767A>G	ENST00000236709.3	-	2	533	c.332T>C	c.(331-333)aTa>aCa	p.I111T		NM_016161.2	NP_057245.1	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	111					protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)	16						AACGTTGTCTATTGCTGACAG	0.423000													3	300					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36162175	36162175	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:36162175A>T	ENST00000303965.4	-	13	2837	c.2348T>A	c.(2347-2349)gTa>gAa	p.V783E		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	783	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TCTCTTTTCTACTGGTGAGTC	0.308000													4	40					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79954603	79954603	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:79954603A>T	ENST00000360280.3	+	48	6810	c.6550A>T	c.(6550-6552)Act>Tct	p.T2184S	VPS13A_ENST00000376634.4_Missense_Mutation_p.T2184S|VPS13A_ENST00000376636.3_Missense_Mutation_p.T2145S|VPS13A_ENST00000357409.5_Missense_Mutation_p.T2184S	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	2184					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TGTCAGTTTTACTTGTGTTAC	0.343000													5	256					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558602	129558602	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:129558602A>T	ENST00000422113.2	-	9	3444	c.3118T>A	c.(3118-3120)Tca>Aca	p.S1040T	TMEM132D_ENST00000389441.4_Missense_Mutation_p.S578T	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	1040						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCCTTTTTGAGGTAGGGGAT	0.483000													5	298					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18729478	18729478	+	Silent	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:18729478A>T	ENST00000513874.1	-	20	3292	c.3153T>A	c.(3151-3153)atT>atA	p.I1051I	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	849										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TGCTCTTGGTAATTGTCTCTC	0.517000													5	249					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62297944	62297944	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:62297944C>T	ENST00000378024.4	-	5	4219	c.3945G>A	c.(3943-3945)gaG>gaA	p.E1315E	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1315					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGAAGTGCATCTCAGGCATCT	0.522000													9	237					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8668756	8668756	+	Missense_Mutation	SNP	C	C	A	rs146637359		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:8668756C>A	ENST00000270328.4	-	4	714	c.448G>T	c.(448-450)Gtg>Ttg	p.V150L	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.V150L|ADAMTS10_ENST00000596709.1_5'UTR			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	150					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TCGTCTGCCACGATCAGGCCG	0.552000													4	143					0.014758	0.0149986	1	1	0
BPIFC	254240	broad.mit.edu	37	22	32833840	32833840	+	Splice_Site	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:32833840T>A	ENST00000397452.1	-	8	766		c.e8-2		BPIFC_ENST00000432451.2_Splice_Site|BPIFC_ENST00000534972.1_Splice_Site|BPIFC_ENST00000300399.3_Splice_Site			Q8NFQ6	BPIL2_HUMAN	BPI fold containing family C							extracellular region	lipopolysaccharide binding|phospholipid binding										TGGTTAAAACTAAATAACCAA	0.303000													6	149					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32541886	32541886	+	Silent	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:32541886A>T	ENST00000360538.2	-	3	2753	c.2637T>A	c.(2635-2637)acT>acA	p.T879T	TOPORS_ENST00000379858.1_Silent_p.T814T	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	879	Interaction with TOP1.|Interaction with UBE2I.|Lys-rich.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		tATGGTGTTTAGTTGTATCAG	0.383000													8	485					0	0	1	0	0
ZDHHC21	340481	broad.mit.edu	37	9	14674264	14674264	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:14674264T>A	ENST00000380916.3	-	4	541	c.75A>T	c.(73-75)ttA>ttT	p.L25F		NM_178566.4	NP_848661.1	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21	25					nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9				GBM - Glioblastoma multiforme(50;4.31e-06)		CAATATTGTATAACCAAACAA	0.353000													5	298					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155314057	155314057	+	Nonsense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:155314057G>A	ENST00000460012.1	-	3	457	c.100C>T	c.(100-102)Cga>Tga	p.R34*	PLCH1_ENST00000447496.2_Nonsense_Mutation_p.R52*|PLCH1_ENST00000414191.1_Nonsense_Mutation_p.R34*|PLCH1_ENST00000340059.7_Nonsense_Mutation_p.R52*|PLCH1_ENST00000334686.6_Nonsense_Mutation_p.R34*|PLCH1_ENST00000494598.1_Nonsense_Mutation_p.R52*			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	52	PH.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGTCGCCATCGGAGGCGTGTC	0.493000													8	416					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59901583	59901583	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:59901583C>T	ENST00000265036.5	-	8	1066	c.999G>A	c.(997-999)atG>atA	p.M333I	DEPDC1B_ENST00000509006.1_5'UTR|DEPDC1B_ENST00000453022.2_Missense_Mutation_p.M333I|DEPDC1B_ENST00000545085.1_Missense_Mutation_p.M306I	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	333	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				TCCTTGCCATCATCCTCATCA	0.418000													6	951					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43544964	43544964	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:43544964C>T	ENST00000220420.5	-	6	862	c.855G>A	c.(853-855)atG>atA	p.M285I	TGM5_ENST00000349114.4_Missense_Mutation_p.M203I	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	285					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TACCTGTGCACATGACGGCAG	0.582000													84	132					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688115	55688115	+	Missense_Mutation	SNP	T	T	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:55688115T>C	ENST00000358433.2	-	1	901	c.902A>G	c.(901-903)gAt>gGt	p.D301G		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TTGTAATACATCCCAGAAGAC	0.368000													3	108					0	0	1	0	0
PKD2	5311	broad.mit.edu	37	4	88967931	88967931	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:88967931A>T	ENST00000237596.2	+	6	1523	c.1457A>T	c.(1456-1458)tAc>tTc	p.Y486F	PKD2_ENST00000508588.1_Intron	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	486						basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TTTATCTTTTACTATGTGGTG	0.383000													5	330					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179411072	179411072	+	Silent	SNP	G	G	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:179411072G>T	ENST00000589042.1	-	342	95210	c.94986C>A	c.(94984-94986)gtC>gtA	p.V31662V	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000359218.5_Silent_p.V22722V|TTN_ENST00000342992.6_Silent_p.V29094V|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342175.6_Silent_p.V22789V|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Silent_p.V22597V|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000591111.1_Silent_p.V30021V|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000438095.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30021	Fibronectin type-III 130.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGCAAAGAGACTTTTTCAC	0.443000													15	218					2.48551e-13	2.6712e-13	1	1	0
NETO1	81832	broad.mit.edu	37	18	70451003	70451003	+	Silent	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr18:70451003G>A	ENST00000327305.6	-	7	1435	c.778C>T	c.(778-780)Cta>Tta	p.L260L	NETO1_ENST00000299430.2_Silent_p.L259L|NETO1_ENST00000583169.1_Silent_p.L260L	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	260	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CCCGTGCGTAGCATGACATCA	0.473000													4	358					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131913110	131913110	+	Missense_Mutation	SNP	C	C	T	rs143690954	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:131913110C>T	ENST00000359827.3	-	6	2685	c.1723G>A	c.(1723-1725)Gtg>Atg	p.V575M	PLXNA4_ENST00000321063.4_Missense_Mutation_p.V575M			Q9HCM2	PLXA4_HUMAN	plexin A4	575						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CTTACCAGCACGTTGTACTGA	0.587000													35	67					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7751105	7751105	+	Missense_Mutation	SNP	G	G	A	rs142420238		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr10:7751105G>A	ENST00000358415.4	+	4	479	c.313G>A	c.(313-315)Gtg>Atg	p.V105M	ITIH2_ENST00000379587.4_Missense_Mutation_p.V94M|ITIH2_ENST00000480387.1_Intron	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	105	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TCAGAATGTCGTGTTTGATGT	0.443000													30	169					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124416373	124416373	+	Silent	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:124416373G>A	ENST00000409039.3	+	74	12778	c.12753G>A	c.(12751-12753)aaG>aaA	p.K4251K	DNAH10OS_ENST00000514254.2_Intron|CCDC92_ENST00000544798.1_Intron|DNAH10_ENST00000538983.1_3'UTR	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4251					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGATGACGAAGTCTCTGGCTG	0.562000													26	231					0	0	1	0	0
SFT2D2	375035	broad.mit.edu	37	1	168200778	168200778	+	Missense_Mutation	SNP	G	G	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:168200778G>T	ENST00000271375.3	+	2	162	c.90G>T	c.(88-90)tgG>tgT	p.W30C	SFT2D2_ENST00000367829.1_Missense_Mutation_p.W30C|SFT2D2_ENST00000471981.1_3'UTR|SFT2D2_ENST00000367825.3_Missense_Mutation_p.W30C	NM_199344.2	NP_955376.1	O95562	SFT2B_HUMAN	SFT2 domain containing 2	30					protein transport|vesicle-mediated transport	integral to membrane				lung(3)|skin(1)	4	all_hematologic(923;0.215)					CATTAAGCTGGAGTACCAGGA	0.363000													6	214					3.09899e-07	3.27407e-07	1	1	0
LY6G6C	80740	broad.mit.edu	37	6	31686952	31686952	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:31686952G>A	ENST00000375819.2	-	3	464	c.299C>T	c.(298-300)gCa>gTa	p.A100V	LY6G6C_ENST00000495859.1_Missense_Mutation_p.A44V	NM_025261.2	NP_079537.1	O95867	LY66C_HUMAN	lymphocyte antigen 6 complex, locus G6C	100	UPAR/Ly6.					anchored to membrane|plasma membrane				NS(1)|large_intestine(1)|lung(1)|skin(1)	4						CCGGGGTCCTGCGCTGTTGCA	0.592000													4	313					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129904328	129904328	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr10:129904328C>G	ENST00000368654.3	-	13	6151	c.5776G>C	c.(5776-5778)Gag>Cag	p.E1926Q	MKI67_ENST00000368653.3_Missense_Mutation_p.E1566Q	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1926	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCAGTTTCTCCACTGGAGTC	0.483000													4	367					0	0	1	0	0
MBD3L1	85509	broad.mit.edu	37	19	8953585	8953585	+	Nonsense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:8953585C>G	ENST00000595891.1	+	3	462	c.231C>G	c.(229-231)taC>taG	p.Y77*	MBD3L1_ENST00000305625.2_Nonsense_Mutation_p.Y77*			Q8WWY6	MB3L1_HUMAN	methyl-CpG binding domain protein 3-like 1	77	Transcription repressor.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	12						TCCAGGCTTACAGCAGTGCAG	0.522000													10	504					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112463456	112463456	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:112463456C>T	ENST00000230538.7	-	20	2929	c.2532G>A	c.(2530-2532)gtG>gtA	p.V844V	LAMA4_ENST00000389463.4_Silent_p.V837V|LAMA4_ENST00000424408.2_Silent_p.V837V|LAMA4_ENST00000522006.1_Silent_p.V837V	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	844	Laminin G-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		AGTGCACTTCCACAGCTGACT	0.507000													7	145					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7832420	7832420	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:7832420A>T	ENST00000327325.5	+	6	1073	c.955A>T	c.(955-957)Act>Tct	p.T319S	CLEC4M_ENST00000248228.4_Missense_Mutation_p.T297S|CLEC4M_ENST00000357361.2_Intron|CLEC4M_ENST00000596363.1_Intron|CLEC4M_ENST00000394122.2_Missense_Mutation_p.T307S|CLEC4M_ENST00000597522.1_Intron|CLEC4M_ENST00000595496.1_Missense_Mutation_p.T183S|CLEC4M_ENST00000359059.5_Missense_Mutation_p.T252S|CLEC4M_ENST00000596707.1_Missense_Mutation_p.T252S|CLEC4M_ENST00000334806.5_Missense_Mutation_p.T268S	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	319	C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						ACAGCTGCAGACTTCCAGGAG	0.552000													7	223					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24522890	24522890	+	Nonsense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:24522890A>T	ENST00000355123.4	-	12	1675	c.1232T>A	c.(1231-1233)tTa>tAa	p.L411*	ITSN2_ENST00000406921.3_Nonsense_Mutation_p.L411*|ITSN2_ENST00000361999.3_Nonsense_Mutation_p.L411*	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	411					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGTTCTTGTAATTCTCTCTG	0.433000													6	239					0	0	1	0	0
RNASEH1	246243	broad.mit.edu	37	2	3597991	3597991	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:3597991C>T	ENST00000315212.3	-	4	836	c.481G>A	c.(481-483)Ggc>Agc	p.G161S		NM_002936.3	NP_002927.2	O60930	RNH1_HUMAN	ribonuclease H1	161	RNase H.				RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			endometrium(1)|kidney(1)|lung(7)|ovary(1)|prostate(2)|skin(1)	13	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		CAGTAAACGCCGATTCCTGCT	0.517000													7	373					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193120496	193120496	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:193120496C>T	ENST00000342695.4	-	30	3858	c.3536G>A	c.(3535-3537)gGc>gAc	p.G1179D	ATP13A4_ENST00000482964.1_5'UTR|ATP13A4_ENST00000392443.3_Missense_Mutation_p.G1160D|ATP13A4_ENST00000400270.2_Missense_Mutation_p.G195D	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1179					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CACTCCTCTGCCACACTCCGG	0.463000													6	218					0	0	1	0	0
RMDN1	51115	broad.mit.edu	37	8	87486540	87486540	+	Silent	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:87486540A>G	ENST00000406452.3	-	10	1101	c.942T>C	c.(940-942)aaT>aaC	p.N314N	RMDN1_ENST00000519966.1_Silent_p.N271N|RMDN1_ENST00000430676.2_Silent_p.N284N|RMDN1_ENST00000523911.1_Intron	NM_016033.2	NP_057117.2			regulator of microtubule dynamics 1																		AAAGTTCTCAATTCTTCTCAC	0.303000													46	77					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117307926	117307926	+	Silent	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:117307926G>A	ENST00000321322.6	-	26	4813	c.4812C>T	c.(4810-4812)gcC>gcT	p.A1604A	DSCAML1_ENST00000527706.1_Silent_p.A1334A	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1544					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CGTACCACGTGGCCTCTCGCA	0.647000													4	101					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37028452	37028452	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:37028452C>T	ENST00000379242.3	+	13	1369	c.1067C>T	c.(1066-1068)cCt>cTt	p.P356L	VIT_ENST00000497382.1_Missense_Mutation_p.P10L|VIT_ENST00000401530.1_Missense_Mutation_p.P320L|VIT_ENST00000379241.3_Missense_Mutation_p.P319L|VIT_ENST00000389975.3_Missense_Mutation_p.P341L|VIT_ENST00000404084.1_Missense_Mutation_p.P293L	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	341	VWFA 1.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				AGAGACAACCCTGCTACTCAC	0.383000													6	609					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048971	9048971	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:9048971G>A	ENST00000397910.4	-	5	32863	c.32660C>T	c.(32659-32661)gCa>gTa	p.A10887V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10889	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTGATCACTGCCCTAGAACT	0.502000													13	1090					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47165938	47165938	+	Splice_Site	SNP	T	T	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:47165938T>A	ENST00000562435.1	-	2	419		c.e2-2		NETO2_ENST00000303155.5_Splice_Site	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2							integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TTAACAACACTAGAGAAATAA	0.313000										HNSCC(25;0.065)			5	480					0	0	1	0	0
HBE1	3046	broad.mit.edu	37	11	5289808	5289808	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:5289808A>G	ENST00000380237.1	-	5	679	c.335T>C	c.(334-336)gTg>gCg	p.V112A	HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000292896.2_Missense_Mutation_p.V112A			P02100	HBE_HUMAN	hemoglobin, epsilon 1	112					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|skin(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGAATAATCACCATCACGTT	0.473000													7	434					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32541877	32541877	+	Missense_Mutation	SNP	A	A	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:32541877A>T	ENST00000360538.2	-	3	2762	c.2646T>A	c.(2644-2646)caT>caA	p.H882Q	TOPORS_ENST00000379858.1_Missense_Mutation_p.H817Q	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	882	Interaction with TOP1.|Interaction with UBE2I.|Lys-rich.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ttttctttttATGGTGTTTAG	0.373000													10	488					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48745244	48745244	+	Nonsense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:48745244G>A	ENST00000285238.8	+	13	1736	c.1656G>A	c.(1654-1656)tgG>tgA	p.W552*	ABCC3_ENST00000427699.1_3'UTR	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	552	ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TCACCCTCTGGGTGTACGTGT	0.572000													4	81					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61738818	61738818	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:61738818C>A	ENST00000325324.6	+	3	316	c.147C>A	c.(145-147)ttC>ttA	p.F49L	IPO11_ENST00000409296.3_Missense_Mutation_p.F89L|KIF2A_ENST00000509663.2_Intron	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	49	Importin N-terminal.					cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		AGAATATTTTCACCAACCACA	0.313000													3	72					2.56e-06	2.65956e-06	1	1	0
CIITA	4261	broad.mit.edu	37	16	11001311	11001311	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:11001311C>T	ENST00000324288.8	+	11	2095	c.1962C>T	c.(1960-1962)ccC>ccT	p.P654P	CIITA_ENST00000537380.1_Intron|CIITA_ENST00000381835.5_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	654	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						ACAGCCCCCCCGGGGCCCTGG	0.682000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								29	41					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30189476	30189476	+	Missense_Mutation	SNP	G	G	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:30189476G>T	ENST00000397771.2	-	18	1969	c.1792C>A	c.(1792-1794)Cca>Aca	p.P598T	ASCC2_ENST00000542393.1_Missense_Mutation_p.P522T|ASCC2_ENST00000307790.3_Missense_Mutation_p.P598T			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GGCTGCAGTGGCACCTGCAAT	0.612000													18	28					2.39187e-15	2.58543e-15	1	1	0
TMC2	117532	broad.mit.edu	37	20	2592911	2592911	+	Silent	SNP	C	C	T	rs144876435	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:2592911C>T	ENST00000358864.1	+	13	1683	c.1668C>T	c.(1666-1668)aaC>aaT	p.N556N	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	556						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CTGGTTGGAACGAGAGTGTCC	0.498000													114	175					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138253483	138253483	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:138253483A>G	ENST00000302763.7	+	11	1532	c.1442A>G	c.(1441-1443)cAa>cGa	p.Q481R	CTNNA1_ENST00000520400.1_3'UTR|CTNNA1_ENST00000518825.1_Missense_Mutation_p.Q481R|CTNNA1_ENST00000355078.5_Missense_Mutation_p.Q378R|CTNNA1_ENST00000540387.1_Missense_Mutation_p.Q111R	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	481					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAACTGGCCCAAGAGAACATG	0.398000													6	660					0	0	1	0	0
CAAP1	79886	broad.mit.edu	37	9	26842367	26842367	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:26842367C>G	ENST00000333916.5	-	6	1106	c.1018G>C	c.(1018-1020)Gaa>Caa	p.E340Q	CAAP1_ENST00000535437.1_Missense_Mutation_p.E195Q|CAAP1_ENST00000520187.1_3'UTR	NM_001167575.1|NM_024828.3	NP_001161047.1|NP_079104.3	Q9H8G2	CI082_HUMAN	caspase activity and apoptosis inhibitor 1	340																	ATCTCAAGTTCTAGCAGCTCC	0.458000													22	154					0	0	1	0	0
CRCP	27297	broad.mit.edu	37	7	65579857	65579857	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:65579857C>G	ENST00000431089.2	+	1	45	c.42C>G	c.(40-42)agC>agG	p.S14R	CRCP_ENST00000398684.2_5'UTR|CRCP_ENST00000338592.5_5'UTR|AC068533.7_ENST00000450043.1_Intron|CRCP_ENST00000395326.3_5'UTR	NM_001142414.1	NP_001135886.1	O75575	RPC9_HUMAN	CGRP receptor component	0					acrosome reaction|innate immune response|response to virus|transcription from RNA polymerase III promoter	DNA polymerase III complex|nucleus|plasma membrane	calcitonin receptor activity|DNA-directed RNA polymerase activity|nucleotide binding			cervix(1)|kidney(1)|lung(4)	6						GCGCGCGGAGCTGGCACCTTG	0.682000													41	60					0	0	0.870114	0	0
KIAA1324	57535	broad.mit.edu	37	1	109740267	109740267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:109740267C>T	ENST00000369939.3	+	16	2476	c.2293C>T	c.(2293-2295)Cga>Tga	p.R765*	KIAA1324_ENST00000529753.1_Nonsense_Mutation_p.R678*|KIAA1324_ENST00000369938.1_3'UTR	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	765					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CCTTGCTGATCGACTTATTGG	0.527000													8	28					0	0	0.307466	0	0
RORC	6097	broad.mit.edu	37	1	151801927	151801927	+	Silent	SNP	C	C	A			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:151801927C>A	ENST00000392697.3	-	3	238	c.210G>T	c.(208-210)ctG>ctT	p.L70L	RORC_ENST00000318247.6_Silent_p.L16L			P51449	RORG_HUMAN	RAR-related orphan receptor C	16					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCTTTGCAGCCAGCAGCTCTG	0.537000													8	126					5.18039e-06	5.51824e-06	0.278610	1	0
FDXR	2232	broad.mit.edu	37	17	72859347	72859347	+	Nonstop_Mutation	SNP	A	A	C			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:72859347A>C	ENST00000455107.2	-	11	1560	c.1144T>G	c.(1144-1146)Tga>Gga	p.*382G	FDXR_ENST00000293195.5_Missense_Mutation_p.V399G|FDXR_ENST00000442102.2_Missense_Mutation_p.V442G|FDXR_ENST00000582944.1_Missense_Mutation_p.V391G|FDXR_ENST00000544854.1_Missense_Mutation_p.V347G|FDXR_ENST00000413947.2_Missense_Mutation_p.V430G|FDXR_ENST00000583917.1_Missense_Mutation_p.V371G|FDXR_ENST00000581530.1_Missense_Mutation_p.V405G|FDXR_ENST00000420580.2_Missense_Mutation_p.V359G			P22570	ADRO_HUMAN	ferredoxin reductase	0					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					TCCTCTCTTCACCCAGCCGCT	0.597000													4	11					0	0	0.278610	0	0
CCKBR	887	broad.mit.edu	37	11	6292065	6292065	+	Silent	SNP	C	C	A	rs1800843	by1000genomes	TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:6292065C>A	ENST00000525462.1	+	4	846	c.843C>A	c.(841-843)ggC>ggA	p.G281G	CCKBR_ENST00000532715.1_Intron|CCKBR_ENST00000334619.2_Intron|CCKBR_ENST00000532396.1_Intron			P32239	GASR_HUMAN	cholecystokinin B receptor	241					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	AAAATCTGGGCGAGGCGGAGC	0.622000													3	42					6.4e-05	6.67234e-05	0.115264	1	0
SSTR5	6755	broad.mit.edu	37	16	1129327	1129327	+	Silent	SNP	G	G	A	rs141899937		TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:1129327G>A	ENST00000293897.4	+	1	547	c.459G>A	c.(457-459)ccG>ccA	p.P153P	SSTR5_ENST00000562758.1_Silent_p.P153P|SSTR5_ENST00000397547.2_Silent_p.P153P	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	153					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity	p.P153P(1)		endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	GGCGCCGCCCGCGTGTGGCCA	0.687000													13	7					0	0	0.500413	0	0
SLC45A1	50651	broad.mit.edu	37	1	8399610	8399610	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:8399610A>G	ENST00000471889.1	+	8	2217	c.1832A>G	c.(1831-1833)tAt>tGt	p.Y611C	SLC45A1_ENST00000289877.8_Missense_Mutation_p.Y611C|SLC45A1_ENST00000377479.2_Missense_Mutation_p.Y645C			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	611					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TTCATCGCCTATCTCGCCTTC	0.607000													107	34					0	0	0.870114	0	0
ALB	213	broad.mit.edu	37	4	74270115	74270115	+	Missense_Mutation	SNP	G	G	A	rs74821926		TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:74270115G>A	ENST00000295897.4	+	1	160	c.71G>A	c.(70-72)cGa>cAa	p.R24Q	ALB_ENST00000509063.1_Missense_Mutation_p.R24Q|ALB_ENST00000401494.3_Missense_Mutation_p.R24Q|ALB_ENST00000503124.1_5'UTR|ALB_ENST00000415165.2_Missense_Mutation_p.R24Q	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	24	Albumin 1.		R -> L (in Jaffna).|R -> P (in Takefu/Honolulu-1).|R -> Q (in Christchurch/Honolulu-2).		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GTGTTTCGTCGAGATGCACGT	0.363000													72	106					0	0	0.870114	0	0
PRR23B	389151	broad.mit.edu	37	3	138739488	138739488	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:138739488G>A	ENST00000329447.5	-	1	280	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	6										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTGGGGCTGCGGGGCCGGCTG	0.721000													6	3					0	0	0.248553	0	0
TGM5	9333	broad.mit.edu	37	15	43544964	43544964	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:43544964C>T	ENST00000220420.5	-	6	862	c.855G>A	c.(853-855)atG>atA	p.M285I	TGM5_ENST00000349114.4_Missense_Mutation_p.M203I	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	285					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TACCTGTGCACATGACGGCAG	0.582000													69	91					0	0	0.870114	0	0
CD109	135228	broad.mit.edu	37	6	74440152	74440152	+	Missense_Mutation	SNP	G	G	A	rs111900767		TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:74440152G>A	ENST00000437994.2	+	4	793	c.362G>A	c.(361-363)cGc>cAc	p.R121H	CD109_ENST00000287097.5_Missense_Mutation_p.R121H|CD109_ENST00000422508.2_Intron	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	121						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AATAGTACCCGCTTATCATTT	0.418000													84	28					0	0	0.870114	0	0
OR6Q1	219952	broad.mit.edu	37	11	57798663	57798663	+	Missense_Mutation	SNP	T	T	G			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:57798663T>G	ENST00000302622.3	+	1	262	c.239T>G	c.(238-240)gTg>gGg	p.V80G	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				TCTGTTACAGTGCCCAAGATG	0.473000													154	55					0	0	0.870114	0	0
CAMTA1	23261	broad.mit.edu	37	1	7797351	7797351	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:7797351G>A	ENST00000303635.7	+	15	3586	c.3379G>A	c.(3379-3381)Gtc>Atc	p.V1127I	CAMTA1_ENST00000439411.2_Missense_Mutation_p.V1127I	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GGAAGCTGCCGTCGTGCTGTA	0.557000			T	WWTR1	epitheliod hemangioendothelioma								6	163					0	0	0.278610	0	0
PLXNA4	91584	broad.mit.edu	37	7	131913110	131913110	+	Missense_Mutation	SNP	C	C	T	rs143690954	by1000genomes	TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:131913110C>T	ENST00000359827.3	-	6	2685	c.1723G>A	c.(1723-1725)Gtg>Atg	p.V575M	PLXNA4_ENST00000321063.4_Missense_Mutation_p.V575M			Q9HCM2	PLXA4_HUMAN	plexin A4	575						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CTTACCAGCACGTTGTACTGA	0.587000													35	46					0	0	0.769981	0	0
ITIH2	3698	broad.mit.edu	37	10	7751105	7751105	+	Missense_Mutation	SNP	G	G	A	rs142420238		TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr10:7751105G>A	ENST00000358415.4	+	4	479	c.313G>A	c.(313-315)Gtg>Atg	p.V105M	ITIH2_ENST00000480387.1_Intron|ITIH2_ENST00000379587.4_Missense_Mutation_p.V94M	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	105	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TCAGAATGTCGTGTTTGATGT	0.443000													25	65					0	0	0.693898	0	0
IL12RB1	3594	broad.mit.edu	37	19	18173055	18173055	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:18173055C>T	ENST00000600835.1	-	15	1954	c.1651G>A	c.(1651-1653)Gcc>Acc	p.A551T	IL12RB1_ENST00000430026.2_Missense_Mutation_p.A551T|IL12RB1_ENST00000593993.1_Missense_Mutation_p.A551T			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	551					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCCAGGGAGGCGAAGAAGATG	0.572000													10	92					0	0	0.387290	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789895	140789895	+	Missense_Mutation	SNP	T	T	A			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:140789895T>A	ENST00000520790.1	+	1	2126	c.2126T>A	c.(2125-2127)cTg>cAg	p.L709Q	PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGTGATTCTGGCCATTGCC	0.587000													98	113					0	0	0.870114	0	0
C1QC	714	broad.mit.edu	37	1	22974251	22974251	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:22974251C>G	ENST00000374639.3	+	3	831	c.713C>G	c.(712-714)tCc>tGc	p.S238C	C1QC_ENST00000374640.4_Missense_Mutation_p.S238C|C1QC_ENST00000374637.1_Missense_Mutation_p.S238C	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	238	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGCGTCTTCTCCGGCTTCCTG	0.642000													13	55					0	0	0.500413	0	0
GTF3C2	2976	broad.mit.edu	37	2	27559290	27559290	+	Missense_Mutation	SNP	A	A	G			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:27559290A>G	ENST00000359541.2	-	8	1559	c.1130T>C	c.(1129-1131)tTt>tCt	p.F377S	AC109828.1_ENST00000592265.1_RNA|AC109828.1_ENST00000416453.2_RNA|AC109828.1_ENST00000585326.1_RNA|GTF3C2_ENST00000264720.3_Missense_Mutation_p.F377S			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	377						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATCGAGCTAAATCTAGAGAA	0.532000													14	54					0	0	0.457914	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38692610	38692610	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:38692610C>T	ENST00000222345.6	+	20	5602	c.5093C>T	c.(5092-5094)cCg>cTg	p.P1698L		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1698					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGGGACCCCCGACCCCCAGG	0.647000													49	87					0	0	0.870114	0	0
ATP1A3	478	broad.mit.edu	37	19	42492233	42492233	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:42492233G>A	ENST00000545399.1	-	4	404	c.251C>T	c.(250-252)aCg>aTg	p.T84M	ATP1A3_ENST00000302102.5_Missense_Mutation_p.T71M|ATP1A3_ENST00000602133.1_Missense_Mutation_p.T41M|ATP1A3_ENST00000543770.1_Missense_Mutation_p.T82M|ATP1A3_ENST00000468774.2_5'UTR	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	71					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						AGGCGGTGGCGTGAGTGCGTT	0.632000													95	126					0	0	0.870114	0	0
ELFN2	114794	broad.mit.edu	37	22	37770867	37770867	+	Silent	SNP	G	G	A	rs149957183		TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:37770867G>A	ENST00000402918.1	-	3	1493	c.708C>T	c.(706-708)aaC>aaT	p.N236N	ELFN2_ENST00000349653.3_Silent_p.N236N|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	236	LRRCT.					cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					CGGTGATGGCGTTGAGGCTGT	0.677000													21	24					0	0	0.693898	0	0
SAMD4B	55095	broad.mit.edu	37	19	39868378	39868378	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:39868378C>T	ENST00000314471.6	+	10	2393	c.1358C>T	c.(1357-1359)cCa>cTa	p.P453L	SAMD4B_ENST00000596368.1_Intron|SAMD4B_ENST00000598913.1_Missense_Mutation_p.P453L	NM_018028.2	NP_060498.2	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	453							protein binding			autonomic_ganglia(1)|breast(1)|endometrium(5)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(2)	15	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCACCAGCTCCAGCTCCCACT	0.657000													46	80					0	0	0.870114	0	0
RMDN1	51115	broad.mit.edu	37	8	87486540	87486540	+	Silent	SNP	A	A	G			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:87486540A>G	ENST00000406452.3	-	10	1101	c.942T>C	c.(940-942)aaT>aaC	p.N314N	RMDN1_ENST00000430676.2_Silent_p.N284N|RMDN1_ENST00000519966.1_Silent_p.N271N|RMDN1_ENST00000523911.1_Intron	NM_016033.2	NP_057117.2			regulator of microtubule dynamics 1																		AAAGTTCTCAATTCTTCTCAC	0.303000													65	96					0	0	0.870114	0	0
RADIL	55698	broad.mit.edu	37	7	4841532	4841532	+	Missense_Mutation	SNP	G	G	A			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:4841532G>A	ENST00000399583.3	-	12	2781	c.2594C>T	c.(2593-2595)cCg>cTg	p.P865L	RADIL_ENST00000538469.1_Missense_Mutation_p.P625L|RADIL_ENST00000536091.1_3'UTR	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	865	Pro-rich.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		AGTACGCTCCGGGGCCACTTC	0.736000													7	9					0	0	0.248553	0	0
NOS1	4842	broad.mit.edu	37	12	117665398	117665398	+	Missense_Mutation	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:117665398C>T	ENST00000317775.6	-	23	4139	c.3454G>A	c.(3454-3456)Gtg>Atg	p.V1152M	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.V1186M	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1152	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGCACCTCCACGATGGTGGGG	0.577000													7	269					0	0	0.278610	0	0
TUBBP5	643224	broad.mit.edu	37	9	141069913	141069913	+	RNA	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:141069913C>T	ENST00000503395.1	+	0	1122																											TGCACCACCACGAGGCCAGCG	0.662000													6	7					0	0	0.278610	0	0
WDR27	253769	broad.mit.edu	37	6	170033136	170033136	+	Missense_Mutation	SNP	C	C	A			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:170033136C>A	ENST00000333572.6	-	21	2649	c.2130G>T	c.(2128-2130)agG>agT	p.R710S	WDR27_ENST00000448612.1_Missense_Mutation_p.R710S|WDR27_ENST00000423258.1_Missense_Mutation_p.R583S|WDR27_ENST00000546525.1_5'UTR			A2RRH5	WDR27_HUMAN	WD repeat domain 27	680										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		CTTCCACGGTCCTGTTCCGGC	0.532000													25	6					3.73808e-20	4.16286e-20	0.693898	1	0
CIITA	4261	broad.mit.edu	37	16	11001311	11001311	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:11001311C>T	ENST00000324288.8	+	11	2095	c.1962C>T	c.(1960-1962)ccC>ccT	p.P654P	CIITA_ENST00000537380.1_Intron|CIITA_ENST00000381835.5_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	654	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						ACAGCCCCCCCGGGGCCCTGG	0.682000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								40	45					0	0	0.812448	0	0
SCYL1	57410	broad.mit.edu	37	11	65293511	65293511	+	Silent	SNP	C	C	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:65293511C>T	ENST00000524944.1	+	3	405	c.372C>T	c.(370-372)atC>atT	p.I124I	SCYL1_ENST00000420247.2_Silent_p.I124I|SCYL1_ENST00000527630.1_Silent_p.I124I|SCYL1_ENST00000279270.6_Silent_p.I124I|SCYL1_ENST00000527009.1_5'UTR|SCYL1_ENST00000270176.5_Silent_p.I124I|SCYL1_ENST00000533862.1_Silent_p.I124I|SCYL1_ENST00000525364.1_Silent_p.I124I			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	124	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						TACACCAGATCGTGGTGAGGT	0.617000													10	99					0	0	0.361761	0	0
PRPF40B	25766	broad.mit.edu	37	12	50025308	50025308	+	Missense_Mutation	SNP	C	C	T	rs149751647		TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:50025308C>T	ENST00000261897.1	+	2	676	c.125C>T	c.(124-126)gCg>gTg	p.A42V	PRPF40B_ENST00000548825.2_Missense_Mutation_p.A70V|PRPF40B_ENST00000380281.1_Missense_Mutation_p.A48V			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	48	Pro-rich.				mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CCAATGGGGGCGCCACCACCA	0.612000													35	187					0	0	0.796494	0	0
TMC2	117532	broad.mit.edu	37	20	2592911	2592911	+	Silent	SNP	C	C	T	rs144876435	byFrequency	TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:2592911C>T	ENST00000358864.1	+	13	1683	c.1668C>T	c.(1666-1668)aaC>aaT	p.N556N	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	556						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CTGGTTGGAACGAGAGTGTCC	0.498000													133	157					0	0	0.870114	0	0
CAAP1	79886	broad.mit.edu	37	9	26842367	26842367	+	Missense_Mutation	SNP	C	C	G			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:26842367C>G	ENST00000333916.5	-	6	1106	c.1018G>C	c.(1018-1020)Gaa>Caa	p.E340Q	CAAP1_ENST00000535437.1_Missense_Mutation_p.E195Q|CAAP1_ENST00000520187.1_3'UTR	NM_001167575.1|NM_024828.3	NP_001161047.1|NP_079104.3	Q9H8G2	CI082_HUMAN	caspase activity and apoptosis inhibitor 1	340																	ATCTCAAGTTCTAGCAGCTCC	0.458000													27	172					0	0	0.729181	0	0
ASCC2	84164	broad.mit.edu	37	22	30189476	30189476	+	Missense_Mutation	SNP	G	G	T			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:30189476G>T	ENST00000397771.2	-	18	1969	c.1792C>A	c.(1792-1794)Cca>Aca	p.P598T	ASCC2_ENST00000307790.3_Missense_Mutation_p.P598T|ASCC2_ENST00000542393.1_Missense_Mutation_p.P522T			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GGCTGCAGTGGCACCTGCAAT	0.612000													21	63					7.87624e-14	8.57636e-14	0.639603	1	0
SSU72	29101	broad.mit.edu	37	1	1500119	1500120	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:1500119_1500120insG	ENST00000359060.4	-	2	283_284	c.257_258insC	c.(256-258)ctgfs	p.L86fs	SSU72_ENST00000291386.3_Intron			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GAGGACCACACGGGGGGTTTTT	0.505													9	560	---	---	---	---					
CROCCP2	84809	broad.mit.edu	37	1	16946501	16946501	+	RNA	DEL	G	G	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:16946501delG	ENST00000412962.1	-	0	1018																											TCGGCCTCCAGCTCCCGCCAT	0.667													6	5	---	---	---	---					
ARID1A	8289	broad.mit.edu	37	1	27105930	27105931	+	Frame_Shift_Ins	INS	-	-	G	rs140055856		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:27105930_27105931insG	ENST00000324856.7	+	20	5912_5913	c.5541_5542insG	c.(5539-5544)ggggggfs	p.GG1847fs	ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.GG1464fs|ARID1A_ENST00000457599.2_Frame_Shift_Ins_p.GG1630fs|ARID1A_ENST00000540690.1_Frame_Shift_Ins_p.GG175fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1847					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.G1848fs*6(3)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCGGATTGGTGGGGGGGACAC	0.579			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								14	227	---	---	---	---					
KIAA1522	57648	broad.mit.edu	37	1	33233494	33233495	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:33233494_33233495insC	ENST00000401073.2	+	2	412_413	c.342_343insC	c.(340-345)cgccccfs	p.RP114fs	KIAA1522_ENST00000373480.1_Frame_Shift_Ins_p.RP55fs|KIAA1522_ENST00000373481.3_Frame_Shift_Ins_p.RP66fs|KIAA1522_ENST00000294521.3_Frame_Shift_Ins_p.RP55fs	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	55			S -> P (in dbSNP:rs3737994).							breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCAGTGGGCGACCCCCCCACCT	0.614													8	157	---	---	---	---					
AGO1	26523	broad.mit.edu	37	1	36354044	36354045	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:36354044_36354045insC	ENST00000373204.4	+	2	255_256	c.42_43insC	c.(40-45)ctccccfs	p.LP14fs	AGO1_ENST00000373206.1_5'UTR	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GCGCTTACCTGCCCCCCCTGCA	0.569													7	156	---	---	---	---					
CSF3R	1441	broad.mit.edu	37	1	36935322	36935323	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:36935322_36935323insG	ENST00000373103.1	-	11	1951_1952	c.1404_1405insC	c.(1402-1407)ccgcgcfs	p.R469fs	CSF3R_ENST00000440588.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000418048.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000373104.1_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000338937.5_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000373106.1_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000361632.4_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000331941.5_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000487540.2_5'UTR	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	469	Fibronectin type-III 4.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGCTCGCGCTGGGGGGGCCCA	0.634													11	272	---	---	---	---					
FAM151A	338094	broad.mit.edu	37	1	55081756	55081757	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:55081756_55081757insG	ENST00000302250.2	-	3	511_512	c.351_352insC	c.(349-354)ccctatfs	p.Y118fs	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Frame_Shift_Ins_p.Y118fs	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	118						integral to membrane		p.T118fs*43(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTGTAGATAGTGGGGGGGTGTG	0.594													11	403	---	---	---	---					
GBP7	388646	broad.mit.edu	37	1	89613321	89613322	+	Frame_Shift_Ins	INS	-	-	C	rs138127555		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:89613321_89613322insC	ENST00000294671.2	-	8	1431_1432	c.1293_1294insG	c.(1291-1296)ggacaafs	p.Q432fs		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	432						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TAGATATTGTGCCCCCCCGGAA	0.436													15	206	---	---	---	---					
EPHX4	253152	broad.mit.edu	37	1	92511121	92511122	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:92511121_92511122insG	ENST00000370383.4	+	4	606_607	c.508_509insG	c.(508-510)gggfs	p.G170fs		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	170						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						TGGCCATGACTGGGGGGGCATG	0.386													22	310	---	---	---	---					
SLC16A1	6566	broad.mit.edu	37	1	113471889	113471890	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:113471889_113471890insG	ENST00000538576.1	-	2	872_873	c.41_42insC	c.(40-42)cgafs	p.R14fs	SLC16A1_ENST00000369626.3_Frame_Shift_Ins_p.R14fs|SLC16A1_ENST00000478835.1_5'UTR|SLC16A1_ENST00000433570.4_Frame_Shift_Ins_p.R14fs	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	14					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	AGCCTCCATCTGGGGGGGTGTA	0.426													9	56	---	---	---	---					
RFX5	5993	broad.mit.edu	37	1	151318740	151318741	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:151318740_151318741insG	ENST00000290524.4	-	3	234_235	c.56_57insC	c.(55-57)cggfs	p.R19fs	RFX5_ENST00000478564.1_5'UTR|RFX5_ENST00000368870.2_Frame_Shift_Ins_p.R19fs|RFX5_ENST00000452671.2_Frame_Shift_Ins_p.R19fs|RFX5_ENST00000452513.2_Frame_Shift_Ins_p.R19fs	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	19						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCACCACCTGGGGGGGCCCT	0.554													10	265	---	---	---	---					
ISG20L2	81875	broad.mit.edu	37	1	156694022	156694023	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:156694022_156694023insG	ENST00000313146.6	-	2	1647_1648	c.865_866insC	c.(865-867)caafs	p.Q289fs	ISG20L2_ENST00000368219.1_Frame_Shift_Ins_p.Q289fs|ISG20L2_ENST00000472824.1_5'UTR	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	289	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTTCCGGTTGAGGGGGGGGATA	0.559													12	120	---	---	---	---					
MRPL24	79590	broad.mit.edu	37	1	156708444	156708445	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:156708444_156708445insG	ENST00000368211.4	-	2	190_191	c.52_53insC	c.(52-54)ttafs	p.L18fs	MRPL24_ENST00000361531.2_Frame_Shift_Ins_p.L18fs	NM_024540.3|NM_145729.2	NP_078816.2|NP_663781.1	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24	18					translation	mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(4)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATAGCGGTAATGGGGGGGCAGA	0.574													8	151	---	---	---	---					
IGSF9	57549	broad.mit.edu	37	1	159904586	159904587	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:159904586_159904587insG	ENST00000368094.1	-	7	896_897	c.699_700insC	c.(697-702)ccagaafs	p.E234fs	IGSF9_ENST00000361509.3_Frame_Shift_Ins_p.E234fs	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	234	Ig-like 3.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCTGTTCTTGGGGGGCACCA	0.569													11	272	---	---	---	---					
ADCY10	55811	broad.mit.edu	37	1	167865905	167865906	+	Frame_Shift_Ins	INS	-	-	G	rs35604923		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:167865905_167865906insG	ENST00000367848.1	-	7	887_888	c.390_391insC	c.(388-393)ccatttfs	p.F131fs	ADCY10_ENST00000367851.4_Frame_Shift_Ins_p.F223fs|ADCY10_ENST00000545172.1_Frame_Shift_Ins_p.F70fs			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	223	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AAATTAAAATTGGGGGGTGGTT	0.332													7	585	---	---	---	---					
PAPPA2	60676	broad.mit.edu	37	1	176762723	176762724	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:176762723_176762724insC	ENST00000367662.3	+	20	6212_6213	c.5048_5049insC	c.(5047-5049)accfs	p.T1683fs		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1683	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTGTGTGTAATCCCCCCCAGTG	0.470													16	372	---	---	---	---					
CACNA1S	779	broad.mit.edu	37	1	201046125	201046126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:201046125_201046126insC	ENST00000362061.3	-	12	1975_1976	c.1749_1750insG	c.(1747-1752)ggggtafs	p.V584fs	CACNA1S_ENST00000367338.3_Frame_Shift_Ins_p.V584fs	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	584					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAGTCATACCTCCCCCCAAAGA	0.574													8	287	---	---	---	---					
FMOD	2331	broad.mit.edu	37	1	203316599	203316600	+	Frame_Shift_Ins	INS	-	-	C	rs139730140	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:203316599_203316600insC	ENST00000354955.4	-	2	1262_1263	c.799_800insG	c.(799-801)gccfs	p.A267fs	FMOD_ENST00000464898.1_5'UTR	NM_002023.4	NP_002014.2	Q06828	FMOD_HUMAN	fibromodulin	267					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	17			BRCA - Breast invasive adenocarcinoma(75;0.171)			CAGCTTGGGCGCCCCCCGGAAG	0.579													9	253	---	---	---	---					
ATP2B4	493	broad.mit.edu	37	1	203667345	203667346	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:203667345_203667346insC	ENST00000357681.5	+	3	1377_1378	c.254_255insC	c.(253-255)accfs	p.T85fs	ATP2B4_ENST00000367218.3_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000367219.3_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000341360.2_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000391954.2_Frame_Shift_Ins_p.T85fs	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	85					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CACAACGTGATCCCCCCCAAAA	0.480													8	182	---	---	---	---					
ACTA1	58	broad.mit.edu	37	1	229567546	229567547	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr1:229567546_229567547insC	ENST00000366684.3	-	6	1013_1014	c.911_912insG	c.(910-912)gacfs	p.D304fs	ACTA1_ENST00000366683.2_Frame_Shift_Ins_p.D216fs	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	304					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	ACATCGTGGTGCCCCCCGACAT	0.589													7	153	---	---	---	---					
NRBP1	29959	broad.mit.edu	37	2	27658017	27658018	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:27658017_27658018insC	ENST00000233557.3	+	8	1416_1417	c.584_585insC	c.(583-585)gccfs	p.A195fs	NRBP1_ENST00000379852.3_Frame_Shift_Ins_p.A195fs|NRBP1_ENST00000379863.3_Frame_Shift_Ins_p.A195fs			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	195	Protein kinase.				ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					CACTCCTGTGACCCCCCCATCA	0.589													7	164	---	---	---	---					
DCTN1	1639	broad.mit.edu	37	2	74593376	74593377	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:74593376_74593377insG	ENST00000361874.3	-	23	3071_3072	c.2754_2755insC	c.(2752-2757)ccgcaafs	p.Q919fs	DCTN1_ENST00000409438.1_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000495643.1_5'UTR|DCTN1_ENST00000394003.3_Frame_Shift_Ins_p.Q912fs|DCTN1_ENST00000407639.2_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000409868.1_Frame_Shift_Ins_p.Q902fs|DCTN1_ENST00000409567.3_Frame_Shift_Ins_p.Q899fs|DCTN1_ENST00000409240.1_Frame_Shift_Ins_p.Q882fs	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	919					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						CCTACCTTGCTGGGGGGCCGCT	0.559													7	510	---	---	---	---					
USP39	10713	broad.mit.edu	37	2	85863227	85863228	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:85863227_85863228insG	ENST00000323701.6	+	7	1011_1012	c.1001_1002insG	c.(1000-1002)cggfs	p.R334fs	USP39_ENST00000459775.1_3'UTR|USP39_ENST00000450066.2_Frame_Shift_Ins_p.R231fs|USP39_ENST00000409025.1_Frame_Shift_Ins_p.R334fs|USP39_ENST00000409766.3_Frame_Shift_Ins_p.R334fs|USP39_ENST00000409470.1_Frame_Shift_Ins_p.R334fs	NM_006590.3	NP_006581.2	Q53GS9	SNUT2_HUMAN	ubiquitin specific peptidase 39	334					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	19						CACTCAGCTCTGGGGGGCACAA	0.416													9	609	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89082293	89082294	+	RNA	INS	-	-	ATTT			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:89082293_89082294insATTT	ENST00000393525.3	+	0	503																											ATTAAAGTCTCATATGTTGAAC	0.332													8	36	---	---	---	---					
MCM6	4175	broad.mit.edu	37	2	136622724	136622725	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:136622724_136622725insC	ENST00000264156.2	-	7	996_997	c.936_937insG	c.(934-939)ggaagafs	p.R313fs		NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	313					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CTGAGCTCTTTCCCCCCAAACT	0.376													7	298	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168099957	168099958	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:168099957_168099958insG	ENST00000409195.1	+	9	2144_2145	c.2055_2056insG	c.(2053-2058)acggggfs	p.TG685fs	XIRP2_ENST00000295237.9_Frame_Shift_Ins_p.TG685fs|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Ins_p.TG463fs|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	510					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGGACATAACTGGGGGGGATGT	0.421													7	167	---	---	---	---					
MYO3B	140469	broad.mit.edu	37	2	171240258	171240259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:171240258_171240259insC	ENST00000334231.6	+	12	1251_1252	c.1251_1252insC	c.(1249-1254)aaccccfs	p.NP417fs	MYO3B_ENST00000408978.4_Frame_Shift_Ins_p.NP408fs|MYO3B_ENST00000409044.3_Frame_Shift_Ins_p.NP408fs|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	408	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GCGCCTCCAATCCCCCCCACAT	0.465													10	203	---	---	---	---					
ITGAV	3685	broad.mit.edu	37	2	187521084	187521085	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:187521084_187521085insG	ENST00000261023.3	+	17	1949_1950	c.1675_1676insG	c.(1675-1677)gggfs	p.G559fs	ITGAV_ENST00000374907.3_Frame_Shift_Ins_p.G523fs|ITGAV_ENST00000433736.2_Frame_Shift_Ins_p.G513fs|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	559					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GACTATTTCAAGGGGGGGACTG	0.431													14	367	---	---	---	---					
ADAM23	8745	broad.mit.edu	37	2	207460860	207460861	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:207460860_207460861insC	ENST00000264377.3	+	24	2661_2662	c.2333_2334insC	c.(2332-2334)cccfs	p.P778fs	ADAM23_ENST00000374415.3_Frame_Shift_Ins_p.P778fs|ADAM23_ENST00000374416.1_Frame_Shift_Ins_p.P778fs	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	778					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding	p.K781fs*3(2)		NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		AGGAACCTTCACCCCCCCAAGG	0.455													7	111	---	---	---	---					
RNF25	64320	broad.mit.edu	37	2	219529039	219529040	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:219529039_219529040insG	ENST00000295704.2	-	10	1460_1461	c.1020_1021insC	c.(1018-1023)ccagccfs	p.A341fs		NM_022453.2	NP_071898.2	Q96BH1	RNF25_HUMAN	ring finger protein 25	341					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGACTGGGCTTGGGGGGATCTA	0.604													7	217	---	---	---	---					
NDUFA10	4705	broad.mit.edu	37	2	240954220	240954221	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr2:240954220_240954221insG	ENST00000252711.2	-	5	704_705	c.604_605insC	c.(604-606)cctfs	p.P202fs	NDUFA10_ENST00000404554.1_Frame_Shift_Ins_p.P202fs|NDUFA10_ENST00000307300.4_Frame_Shift_Ins_p.P242fs	NM_004544.3	NP_004535.1	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	202					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AATCACCAGGTGGGGGGGCAGG	0.535													22	482	---	---	---	---					
SRGAP3	9901	broad.mit.edu	37	3	9034599	9034600	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:9034599_9034600insC	ENST00000383836.3	-	20	2975_2976	c.2548_2549insG	c.(2548-2550)gatfs	p.D850fs	SRGAP3_ENST00000360413.3_Frame_Shift_Ins_p.D826fs	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	850					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCGGCCCATCACCCCCCCAAAG	0.554			T	RAF1	pilocytic astrocytoma								11	225	---	---	---	---					
FANCD2	2177	broad.mit.edu	37	3	10088407	10088410	+	Splice_Site	DEL	AGTA	AGTA	-	rs146316187		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:10088407_10088410delAGTA	ENST00000287647.3	+	15	1371	c.1278_splice	c.e15+1	p.426_splice	FANCD2_ENST00000383807.1_Splice_Site_p.426_splice|FANCD2_ENST00000383806.1_Splice_Site_p.426_splice|FANCD2_ENST00000419585.1_Splice_Site_p.426_splice	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	426					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTCATTACTTAGTAAGTGTCAGAG	0.358			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	149	---	---	---	---					
TATDN2	9797	broad.mit.edu	37	3	10312538	10312539	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:10312538_10312539insG	ENST00000287652.4	+	4	2723_2724	c.1672_1673insG	c.(1672-1674)gggfs	p.G558fs	RP11-438J1.1_ENST00000450534.1_3'UTR|TATDN2_ENST00000448281.2_Frame_Shift_Ins_p.G558fs	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	558						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						GGATCTGGTCTGGGGGGCCTTT	0.505													7	749	---	---	---	---					
DCLK3	85443	broad.mit.edu	37	3	36759523	36759524	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:36759523_36759524insG	ENST00000416516.2	-	4	2220_2221	c.1730_1731insC	c.(1729-1731)ctafs	p.L577fs		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	577	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TGTCCCAGTAAGGGGGGAGGAA	0.540													7	675	---	---	---	---					
MLH1	4292	broad.mit.edu	37	3	37070348	37070349	+	Frame_Shift_Ins	INS	-	-	C	rs63750855		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:37070348_37070349insC	ENST00000231790.2	+	13	1699_1700	c.1483_1484insC	c.(1483-1485)cccfs	p.P495fs	MLH1_ENST00000458205.2_Frame_Shift_Ins_p.P254fs|MLH1_ENST00000455445.2_Frame_Shift_Ins_p.P254fs|MLH1_ENST00000536378.1_Frame_Shift_Ins_p.P254fs|MLH1_ENST00000435176.1_Frame_Shift_Ins_p.P397fs|MLH1_ENST00000539477.1_Frame_Shift_Ins_p.P254fs	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	495	Interaction with EXO1.				mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.T495A(1)|p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						TGCAGCTTGTACCCCCCGGAGA	0.470		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				12	1092	---	---	---	---					
RNF123	63891	broad.mit.edu	37	3	49740082	49740083	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:49740082_49740083insC	ENST00000327697.6	+	20	1790_1791	c.1646_1647insC	c.(1645-1647)tccfs	p.S549fs	RNF123_ENST00000432042.1_Frame_Shift_Ins_p.S403fs	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	549						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CCCATGCTCTGCCCCCCTGAGT	0.550													10	692	---	---	---	---					
RBM6	10180	broad.mit.edu	37	3	50005144	50005145	+	Frame_Shift_Ins	INS	-	-	G	rs141234052		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:50005144_50005145insG	ENST00000266022.4	+	3	545_546	c.286_287insG	c.(286-288)gggfs	p.G96fs	RBM6_ENST00000443081.1_5'UTR|RBM6_ENST00000442092.1_Intron|RBM6_ENST00000441115.1_Intron|RBM6_ENST00000539992.1_Intron|RBM6_ENST00000422955.1_Intron	NM_005777.2	NP_005768.1	P78332	RBM6_HUMAN	RNA binding motif protein 6	96					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		ACATGATTTCAGGGGGGGAGAT	0.495													11	297	---	---	---	---					
VPRBP	9730	broad.mit.edu	37	3	51457614	51457615	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:51457614_51457615insG	ENST00000335891.5	-	7	1471_1472	c.1462_1463insC	c.(1462-1464)gggfs	p.G488fs				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	937					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TAGCGGACCCTGGGGGGGCCGT	0.589													13	133	---	---	---	---					
PRKCD	5580	broad.mit.edu	37	3	53220652	53220653	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:53220652_53220653insG	ENST00000394729.2	+	13	1621_1622	c.1293_1294insG	c.(1291-1296)aaggggfs	p.KG431fs	PRKCD_ENST00000330452.3_Frame_Shift_Ins_p.KG431fs	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	431	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AGTTCCTCAACGGGGGGGACCT	0.604													17	872	---	---	---	---					
KCTD6	200845	broad.mit.edu	37	3	58486771	58486772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:58486771_58486772insG	ENST00000355076.6	+	2	1109_1110	c.126_127insG	c.(124-129)ttggggfs	p.LG42fs	KCTD6_ENST00000479470.1_3'UTR|KCTD6_ENST00000490264.1_Frame_Shift_Ins_p.LG42fs|KCTD6_ENST00000404589.3_Frame_Shift_Ins_p.LG42fs	NM_153331.3	NP_699162.3	Q8NC69	KCTD6_HUMAN	potassium channel tetramerization domain containing 6	42	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|large_intestine(2)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		GAGCTATGTTTGGGGGGGACTT	0.465													12	420	---	---	---	---					
VGLL3	389136	broad.mit.edu	37	3	87018182	87018183	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:87018182_87018183insC	ENST00000398399.2	-	3	857_858	c.494_495insG	c.(493-495)ggtfs	p.G165fs	VGLL3_ENST00000383698.3_Frame_Shift_Ins_p.G165fs	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CAGGATGAACTCCCCCCAAACA	0.579													7	464	---	---	---	---					
MYLK	4638	broad.mit.edu	37	3	123368043	123368044	+	Splice_Site	INS	-	-	G	rs138786404		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:123368043_123368044insG	ENST00000360772.3	-	26	4667		c.e26-2		MYLK_ENST00000475616.1_Splice_Site|MYLK_ENST00000354792.5_Splice_Site|MYLK_ENST00000360304.3_Splice_Site|MYLK_ENST00000359169.1_Splice_Site|MYLK_ENST00000346322.5_Splice_Site			Q15746	MYLK_HUMAN	myosin light chain kinase						aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTTCGGCTCTGGGGGGGGCAC	0.624													21	208	---	---	---	---					
MUC13	56667	broad.mit.edu	37	3	124646628	124646629	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:124646628_124646629insG	ENST00000311075.3	-	2	299_300	c.261_262insC	c.(259-264)cctaatfs	p.N88fs		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	88	Thr-rich.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						GTACTAATTATGGGGGGAGCAG	0.441													9	1307	---	---	---	---					
GRK7	131890	broad.mit.edu	37	3	141535707	141535708	+	Frame_Shift_Ins	INS	-	-	G	rs149574289		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:141535707_141535708insG	ENST00000264952.2	+	4	1614_1615	c.1477_1478insG	c.(1477-1479)gggfs	p.G493fs		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	493	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity	p.R493L(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CTCTGAGGTTCGGGGGGTGGAA	0.460													20	1163	---	---	---	---					
MME	4311	broad.mit.edu	37	3	154884713	154884714	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:154884713_154884714insC	ENST00000460393.1	+	18	1803_1804	c.1683_1684insC	c.(1681-1686)caccccfs	p.HP561fs	MME_ENST00000492661.1_Frame_Shift_Ins_p.HP561fs|MME-AS1_ENST00000484721.1_RNA|MME_ENST00000493237.1_Frame_Shift_Ins_p.HP561fs|MME_ENST00000462745.1_Frame_Shift_Ins_p.HP561fs|MME_ENST00000360490.2_Frame_Shift_Ins_p.HP561fs	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	561					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.Q561H(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GCATTCTGCAGCCCCCCTTCTT	0.446													8	435	---	---	---	---					
SAMD7	344658	broad.mit.edu	37	3	169646267	169646268	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:169646267_169646268insG	ENST00000428432.2	+	7	1331_1332	c.942_943insG	c.(940-945)atggggfs	p.MG314fs	SAMD7_ENST00000335556.3_Frame_Shift_Ins_p.MG314fs	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	314										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TGGTTACAATTGGGGGGAATCT	0.381													8	586	---	---	---	---					
FNDC3B	64778	broad.mit.edu	37	3	172096209	172096210	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:172096209_172096210insC	ENST00000336824.4	+	24	3257_3258	c.3158_3159insC	c.(3157-3159)gccfs	p.A1053fs	FNDC3B_ENST00000415807.2_Frame_Shift_Ins_p.A1053fs|FNDC3B_ENST00000416957.1_Frame_Shift_Ins_p.A1053fs	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1053						endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACCAAAAGTGTCCCCCCCACCA	0.470													7	186	---	---	---	---					
KIAA0226	9711	broad.mit.edu	37	3	197427914	197427915	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr3:197427914_197427915insG	ENST00000273582.5	-	7	1195_1196	c.650_651insC	c.(649-651)cgtfs	p.R217fs	KIAA0226_ENST00000296343.5_Frame_Shift_Ins_p.R277fs|KIAA0226_ENST00000389665.5_Frame_Shift_Ins_p.R277fs|KIAA0226_ENST00000449205.1_Frame_Shift_Ins_p.R277fs	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	277	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		AGACTGAAACTGGGGGGGCTTG	0.554													12	156	---	---	---	---					
FAM193A	8603	broad.mit.edu	37	4	2661592	2661593	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:2661592_2661593insC	ENST00000324666.5	+	8	1034_1035	c.683_684insC	c.(682-684)gccfs	p.A228fs	FAM193A_ENST00000505311.1_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000502458.1_Frame_Shift_Ins_p.A252fs|FAM193A_ENST00000545951.1_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000382839.3_Frame_Shift_Ins_p.A228fs	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	228										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						GGTATCATGGACCCCCCCGTCA	0.525													14	535	---	---	---	---					
GPR125	166647	broad.mit.edu	37	4	22390062	22390063	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:22390062_22390063insG	ENST00000334304.5	-	19	3500_3501	c.3231_3232insC	c.(3229-3234)ccactcfs	p.L1078fs	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	1078					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				CCATTAGAGTTGGGGGGCTGGA	0.500													9	235	---	---	---	---					
TBC1D1	23216	broad.mit.edu	37	4	38091622	38091623	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:38091622_38091623insC	ENST00000261439.4	+	13	2475_2476	c.2120_2121insC	c.(2119-2121)gccfs	p.A707fs	TBC1D1_ENST00000508802.1_Frame_Shift_Ins_p.A801fs	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	707						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GGGCCCTTTGGCCCCCCACCAG	0.495													7	268	---	---	---	---					
KIAA1211	57482	broad.mit.edu	37	4	57181627	57181628	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:57181627_57181628insC	ENST00000504228.1	+	6	2064_2065	c.1959_1960insC	c.(1957-1962)aacccgfs	p.NP653fs	KIAA1211_ENST00000264229.6_Frame_Shift_Ins_p.NP653fs|KIAA1211_ENST00000541073.1_Frame_Shift_Ins_p.NP646fs			Q6ZU35	K1211_HUMAN	KIAA1211	653										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GGAAGGCTAAGCCCCGCCAGGA	0.683													9	76	---	---	---	---					
UNC5C	8633	broad.mit.edu	37	4	96091356	96091357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:96091356_96091357insG	ENST00000453304.1	-	15	2926_2927	c.2578_2579insC	c.(2578-2580)gacfs	p.D860fs		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	860	Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCCTCTCGTCTGGGGGGCATCC	0.599													7	454	---	---	---	---					
TET2	54790	broad.mit.edu	37	4	106155956	106155957	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:106155956_106155957insA	ENST00000540549.1	+	3	1717_1718	c.857_858insA	c.(856-858)caafs	p.Q286fs	TET2_ENST00000413648.2_Frame_Shift_Ins_p.Q286fs|TET2_ENST00000305737.2_Frame_Shift_Ins_p.Q286fs|TET2_ENST00000380013.4_Frame_Shift_Ins_p.Q286fs|TET2_ENST00000513237.1_Frame_Shift_Ins_p.Q307fs|TET2_ENST00000545826.1_Frame_Shift_Ins_p.Q286fs|TET2_ENST00000394764.1_Frame_Shift_Ins_p.Q286fs			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	286					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		GAGCTGCCTCCAAAGCCAGCTG	0.490			"""Mis N, F"""		MDS								9	221	---	---	---	---					
ANK2	287	broad.mit.edu	37	4	114280134	114280135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:114280134_114280135insG	ENST00000357077.4	+	38	10413_10414	c.10360_10361insG	c.(10360-10362)gggfs	p.G3454fs	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000264366.6_Frame_Shift_Ins_p.G3421fs|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3421					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.T3457fs*8(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCTTCCTGCAGGGGGGGCACG	0.455													23	224	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134071648	134071649	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:134071648_134071649insC	ENST00000264360.4	+	1	1179_1180	c.353_354insC	c.(352-354)accfs	p.T118fs		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	118	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S121fs*13(1)		NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTAATGACAACCCCCCCTCTT	0.604													7	297	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134071967	134071968	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:134071967_134071968insC	ENST00000264360.4	+	1	1498_1499	c.672_673insC	c.(670-675)ctccccfs	p.LP224fs		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	224	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		gagcaggCCTGCCCCCCCAGCA	0.668													12	123	---	---	---	---					
GAB1	2549	broad.mit.edu	37	4	144361498	144361499	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:144361498_144361499insC	ENST00000262995.4	+	6	1975_1976	c.1548_1549insC	c.(1546-1551)ccccccfs	p.PP516fs	GAB1_ENST00000262994.4_Frame_Shift_Ins_p.PP516fs|GAB1_ENST00000505913.1_Frame_Shift_Ins_p.PP413fs	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	516	Pro-rich.				cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					ACTGTGAACCACCCCCCGTGGA	0.515													8	209	---	---	---	---					
GPM6A	2823	broad.mit.edu	37	4	176622884	176622885	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:176622884_176622885insC	ENST00000280187.7	-	3	116_117	c.71_72insG	c.(70-72)gatfs	p.D24fs	GPM6A_ENST00000506894.1_Frame_Shift_Ins_p.D13fs|GPM6A_ENST00000393658.2_Frame_Shift_Ins_p.D24fs|GPM6A_ENST00000515090.1_Frame_Shift_Ins_p.D17fs	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	24						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		CATAGGGAATGCCCCCCAGGCA	0.431													8	462	---	---	---	---					
TRIML2	205860	broad.mit.edu	37	4	189012770	189012771	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:189012770_189012771insG	ENST00000512729.1	-	7	1294_1295	c.920_921insC	c.(919-921)cctfs	p.P307fs	TRIML2_ENST00000326754.3_Frame_Shift_Ins_p.P332fs	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	307	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GCCTTTTCAGAGGGGGGAAGAC	0.559													7	666	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24487951	24487952	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:24487951_24487952insG	ENST00000264463.4	-	12	2694_2695	c.2187_2188insC	c.(2185-2190)ccacgafs	p.R730fs	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	730					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGTGAGTCGTAGGGGGGTGCGG	0.460										HNSCC(23;0.051)			7	393	---	---	---	---					
NIPBL	25836	broad.mit.edu	37	5	36986119	36986120	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:36986119_36986120insG	ENST00000282516.8	+	10	3336_3337	c.2837_2838insG	c.(2836-2838)tggfs	p.W946fs	NIPBL_ENST00000448238.2_Frame_Shift_Ins_p.W946fs|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	946					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGTTATTTGTTGGGGGGCAGGT	0.391													7	367	---	---	---	---					
FYB	2533	broad.mit.edu	37	5	39202090	39202091	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:39202090_39202091insC	ENST00000351578.6	-	2	1162_1163	c.972_973insG	c.(970-975)ggcatgfs	p.M325fs	FYB_ENST00000540520.1_Frame_Shift_Ins_p.M335fs|FYB_ENST00000515010.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000505428.1_Frame_Shift_Ins_p.M325fs|FYB_ENST00000512982.1_Frame_Shift_Ins_p.M325fs	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	325					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.P325A(3)|p.P335A(1)		endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TGGCCCCATGGCCCCCCCACTG	0.540													15	212	---	---	---	---					
MAP1B	4131	broad.mit.edu	37	5	71495076	71495077	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:71495076_71495077insC	ENST00000296755.7	+	5	6192_6193	c.5894_5895insC	c.(5893-5895)accfs	p.T1965fs		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1965						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AAGACCACCAGCCCCCCCGAAG	0.485													22	557	---	---	---	---					
ENC1	8507	broad.mit.edu	37	5	73931125	73931126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:73931125_73931126insC	ENST00000302351.4	-	2	2315_2316	c.1185_1186insG	c.(1183-1188)ggacacfs	p.H396fs	ENC1_ENST00000537006.1_Frame_Shift_Ins_p.H396fs|ENC1_ENST00000510316.1_Frame_Shift_Ins_p.H323fs	NM_003633.3	NP_003624.1	O14682	ENC1_HUMAN	ectodermal-neural cortex 1 (with BTB domain)	396					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	20		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		GCGGCCGTGTGCCCCCCAACCA	0.599													7	200	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74226290	74226291	+	RNA	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:74226290_74226291insC	ENST00000505200.1	-	0	335																											TGGGAATAATTCCCCCCATTCT	0.381													8	569	---	---	---	---					
GCNT4	51301	broad.mit.edu	37	5	74324982	74324983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:74324982_74324983insG	ENST00000322348.4	-	1	1741_1742	c.880_881insC	c.(880-882)taafs	p.*294fs		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	294					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	p.H294fs*2(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		CTGAATGTTATGGGGGGGTGCT	0.366													14	239	---	---	---	---					
PCSK1	5122	broad.mit.edu	37	5	95746639	95746640	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:95746639_95746640insC	ENST00000311106.3	-	8	1170_1171	c.933_934insG	c.(931-936)gggtcafs	p.S312fs	PCSK1_ENST00000508626.1_Frame_Shift_Ins_p.S265fs|PCSK1_ENST00000513085.1_Intron|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	312	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity	p.R312C(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTCCCTGACGCCCCCCGTTTC	0.530													7	430	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127610310	127610311	+	Frame_Shift_Ins	INS	-	-	C	rs151053868		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:127610310_127610311insC	ENST00000508053.1	-	66	8633_8634	c.7659_7660insG	c.(7657-7662)ggttacfs	p.Y2554fs	FBN2_ENST00000262464.4_Frame_Shift_Ins_p.Y2554fs			P35556	FBN2_HUMAN	fibrillin 2	2554	EGF-like 43; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTACAGGTAAACCCCCCCAGGG	0.421													18	329	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127648336	127648337	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:127648336_127648337insG	ENST00000508053.1	-	43	5842_5843	c.4868_4869insC	c.(4867-4869)cgtfs	p.R1623fs	FBN2_ENST00000262464.4_Frame_Shift_Ins_p.R1623fs			P35556	FBN2_HUMAN	fibrillin 2	1623	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent	p.P1623P(2)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGCTATTGACAGGGGGGCATGT	0.505													12	1178	---	---	---	---					
FNIP1	96459	broad.mit.edu	37	5	131013435	131013435	+	Frame_Shift_Del	DEL	C	C	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:131013435delC	ENST00000307968.7	-	12	1395	c.1396delG	c.(1396-1398)cafs	p.A466fs	FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000511848.1_Frame_Shift_Del_p.A494fs|FNIP1_ENST00000307954.8_Frame_Shift_Del_p.A449fs|FNIP1_ENST00000510461.1_Frame_Shift_Del_p.A494fs	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TGAGTCTTTGCCAACATGTCC	0.383													100	204	---	---	---	---					
SLC22A5	6584	broad.mit.edu	37	5	131722730	131722731	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:131722730_131722731insC	ENST00000245407.3	+	5	1059_1060	c.838_839insC	c.(838-840)cccfs	p.P280fs	SLC22A5_ENST00000435065.2_Frame_Shift_Ins_p.P304fs	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	280					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CATCCCTGAGTCCCCCCGATGG	0.545											OREG0016767	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	924	---	---	---	---					
TCF7	6932	broad.mit.edu	37	5	133473764	133473765	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:133473764_133473765insC	ENST00000395029.1	+	4	651_652	c.456_457insC	c.(454-459)caccccfs	p.HP152fs	TCF7_ENST00000378560.4_Frame_Shift_Ins_p.HP37fs|TCF7_ENST00000520958.1_Frame_Shift_Ins_p.HP37fs|TCF7_ENST00000378564.1_Frame_Shift_Ins_p.HP152fs|TCF7_ENST00000321603.6_Frame_Shift_Ins_p.HP152fs|TCF7_ENST00000342854.5_Frame_Shift_Ins_p.HP152fs|TCF7_ENST00000518915.1_Frame_Shift_Ins_p.HP37fs|TCF7_ENST00000321584.4_Frame_Shift_Ins_p.HP152fs|TCF7_ENST00000395023.1_Frame_Shift_Ins_p.HP37fs|TCF7_ENST00000432532.2_Frame_Shift_Ins_p.HP37fs			P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific, HMG-box)	152					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGCCAATCAGCCCCCCCACGG	0.574													9	187	---	---	---	---					
SLC25A48	153328	broad.mit.edu	37	5	135207263	135207264	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:135207263_135207264insG	ENST00000274513.5	+	5	707_708	c.535_536insG	c.(535-537)gggfs	p.G179fs	SLC25A48_ENST00000420621.1_Frame_Shift_Ins_p.G179fs|SLC25A48_ENST00000425402.1_Intron|SLC25A48_ENST00000433282.2_Frame_Shift_Ins_p.G125fs|SLC25A48_ENST00000412661.2_Intron			Q6ZT89	S2548_HUMAN	solute carrier family 25, member 48	179					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						GGGGCTATACCGGGGGGCCAGT	0.604													7	371	---	---	---	---					
PCDHGC4	56098	broad.mit.edu	37	5	140865128	140865129	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:140865128_140865129insC	ENST00000306593.1	+	1	388_389	c.388_389insC	c.(388-390)cccfs	p.P130fs	PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATGATCACGCCCCCCGTTTT	0.574													16	400	---	---	---	---					
PCDHGC5	56097	broad.mit.edu	37	5	140870530	140870531	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:140870530_140870531insC	ENST00000252087.1	+	1	1723_1724	c.1723_1724insC	c.(1723-1725)cccfs	p.P575fs	PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		575	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAACACTCAGCCCCCCAGCGT	0.589													7	256	---	---	---	---					
ARAP3	64411	broad.mit.edu	37	5	141049341	141049342	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:141049341_141049342insC	ENST00000239440.4	-	16	2351_2352	c.2286_2287insG	c.(2284-2289)ggggatfs	p.D763fs	ARAP3_ENST00000508305.1_Frame_Shift_Ins_p.D665fs|ARAP3_ENST00000513878.1_Frame_Shift_Ins_p.D425fs	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	763					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TGCTGGATCCTCCCCCCAGCGA	0.579													17	801	---	---	---	---					
ARHGAP26	23092	broad.mit.edu	37	5	142586762	142586763	+	Splice_Site	INS	-	-	C	rs144777273		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:142586762_142586763insC	ENST00000378004.3	+	21	2343_2344		c.e21-1		ARHGAP26_ENST00000274498.4_Splice_Site|ARHGAP26_ENST00000486650.1_Intron	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26						actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding	p.?(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGTCTTGCAGCCCCCCGAATC	0.579													12	514	---	---	---	---					
LARS	51520	broad.mit.edu	37	5	145523013	145523014	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:145523013_145523014insC	ENST00000394434.2	-	19	2004_2005	c.1838_1839insG	c.(1837-1839)gaafs	p.E613fs	LARS_ENST00000274562.9_Frame_Shift_Ins_p.E586fs|LARS_ENST00000510191.1_Frame_Shift_Ins_p.E559fs|LARS_ENST00000545646.1_Frame_Shift_Ins_p.E567fs	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	613					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CATGCAAGTTACCCCCCTGCAA	0.450													15	1012	---	---	---	---					
SLC6A7	6534	broad.mit.edu	37	5	149581960	149581961	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:149581960_149581961insG	ENST00000230671.2	+	7	1280_1281	c.909_910insG	c.(907-912)ttggggfs	p.LG303fs	SLC6A7_ENST00000524041.1_Frame_Shift_Ins_p.LG303fs	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	303						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	GTGTGGGCTTCGGGGGGCTCCT	0.569													7	423	---	---	---	---					
FNDC9	408263	broad.mit.edu	37	5	156769909	156769910	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:156769909_156769910insC	ENST00000312349.4	-	2	822_823	c.635_636insG	c.(634-636)gggfs	p.G212fs	CYFIP2_ENST00000435847.2_Intron|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000347377.6_Intron|CYFIP2_ENST00000377576.3_Intron|CYFIP2_ENST00000541131.1_Intron|CYFIP2_ENST00000318218.6_Intron|CYFIP2_ENST00000521420.1_Intron|CYFIP2_ENST00000442283.2_Intron	NM_001001343.3	NP_001001343.2	Q8TBE3	FNDC9_HUMAN	fibronectin type III domain containing 9	212						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	9						GTGGGTCACCACCCCCCCTCTG	0.584											OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	192	---	---	---	---					
TRIM41	90933	broad.mit.edu	37	5	180651435	180651436	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:180651435_180651436insG	ENST00000315073.5	+	1	1146_1147	c.436_437insG	c.(436-438)gggfs	p.G146fs	TRIM41_ENST00000351937.5_Frame_Shift_Ins_p.G146fs	NM_033549.4	NP_291027.3	Q8WV44	TRI41_HUMAN	tripartite motif containing 41	146	Glu-rich.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|prostate(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ggaggacctgaggggggaggat	0.629													7	185	---	---	---	---					
EXOC2	55770	broad.mit.edu	37	6	637793	637794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:637793_637794insG	ENST00000230449.4	-	2	160_161	c.25_26insC	c.(25-27)tgtfs	p.C9fs	EXOC2_ENST00000448181.3_Intron	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	9	IPT/TIG.				exocytosis|protein transport			p.Q6fs*28(1)		breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GCCGGTCACAAGGGGGGGTTGT	0.485													8	309	---	---	---	---					
GCNT2	2651	broad.mit.edu	37	6	10557409	10557410	+	Frame_Shift_Ins	INS	-	-	C	rs55808116		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:10557409_10557410insC	ENST00000316170.3	+	1	1170_1171	c.753_754insC	c.(751-756)ccccccfs	p.PP251fs	GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000410107.1_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	253						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TGAAACCGCCTCCCCCCCATAA	0.485													10	307	---	---	---	---					
PHACTR1	221692	broad.mit.edu	37	6	13206134	13206135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:13206134_13206135insG	ENST00000379350.1	+	7	881_882	c.752_753insG	c.(751-753)gggfs	p.G251fs	PHACTR1_ENST00000332995.7_Frame_Shift_Ins_p.G251fs|PHACTR1_ENST00000457702.2_Frame_Shift_Ins_p.G106fs|PHACTR1_ENST00000379345.2_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	251						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGTATGCCCGTGGGGGGGCCAG	0.599													13	179	---	---	---	---					
DCDC2	51473	broad.mit.edu	37	6	24205282	24205283	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:24205282_24205283insC	ENST00000378454.3	-	8	1271_1272	c.970_971insG	c.(970-972)agcfs	p.S324fs	DCDC2_ENST00000378450.3_Frame_Shift_Ins_p.S77fs	NM_001195610.1|NM_016356.3	NP_001182539.1|NP_057440.2	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	324					cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				GACTTCTGCTGCCCCCCGTGTT	0.411													17	1303	---	---	---	---					
GABBR1	2550	broad.mit.edu	37	6	29577143	29577144	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:29577143_29577144insG	ENST00000377034.4	-	15	2056_2057	c.1721_1722insC	c.(1720-1722)cgcfs	p.R574fs	GABBR1_ENST00000377016.4_Frame_Shift_Ins_p.R512fs|GABBR1_ENST00000355973.3_Frame_Shift_Ins_p.R457fs|GABBR1_ENST00000376977.3_Intron|GABBR1_ENST00000377012.4_Frame_Shift_Ins_p.R457fs	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	574					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	TCTGGTCAGCTGGGGGGGACCC	0.540													8	222	---	---	---	---					
PPP1R10	5514	broad.mit.edu	37	6	30569333	30569334	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:30569333_30569334insG	ENST00000376511.2	-	20	3367_3368	c.2815_2816insC	c.(2815-2817)gccfs	p.A939fs		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	939					protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TCCCTAGGGCAGGGGGGGCCCA	0.569													10	125	---	---	---	---					
BAG6	7917	broad.mit.edu	37	6	31608570	31608571	+	Splice_Site	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:31608570_31608571insG	ENST00000404765.2	-	21	3221_3222	c.2934_splice	c.e21+1	p.A978_splice	BAG6_ENST00000375976.4_Splice_Site_p.A942_splice|BAG6_ENST00000362049.6_Splice_Site_p.A942_splice|BAG6_ENST00000375964.6_Splice_Site_p.A948_splice|BAG6_ENST00000211379.5_Splice_Site_p.A942_splice|BAG6_ENST00000439687.2_Splice_Site_p.A816_splice			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	948					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GTCCCTTACCTGGGGGGGATCA	0.535													7	191	---	---	---	---					
C6orf25	80739	broad.mit.edu	37	6	31692528	31692529	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:31692528_31692529insC	ENST00000375809.3	+	5	558_559	c.547_548insC	c.(547-549)cccfs	p.P183fs	C6orf25_ENST00000375805.2_Frame_Shift_Ins_p.CP152fs|C6orf25_ENST00000375810.4_Frame_Shift_Ins_p.P183fs|C6orf25_ENST00000480039.1_Intron	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	0						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TTCAGCTCTGTCCCCCCCACAT	0.579													10	356	---	---	---	---					
FKBPL	63943	broad.mit.edu	37	6	32097085	32097086	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:32097085_32097086insC	ENST00000375156.3	-	2	742_743	c.472_473insG	c.(472-474)gctfs	p.A158fs		NM_022110.3	NP_071393.2	Q9UIM3	FKBPL_HUMAN	FK506 binding protein like	158					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity										CTCTATGAGCTCCCCCCAAGTT	0.589													11	349	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32522756	32522756	+	RNA	DEL	A	A	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:32522756delA	ENST00000411500.1	-	0	458					NR_001298.1																						GGACTAGGAGAAAAAAAGGTA	0.517													10	25	---	---	---	---					
BRD2	6046	broad.mit.edu	37	6	32948228	32948229	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:32948228_32948229insC	ENST00000395289.2	+	13	3962_3963	c.2361_2362insC	c.(2359-2364)aaccccfs	p.NP787fs	BRD2_ENST00000374825.4_Frame_Shift_Ins_p.NP752fs|BRD2_ENST00000443797.2_Frame_Shift_Ins_p.NP632fs|BRD2_ENST00000449085.2_Frame_Shift_Ins_p.NP705fs|BRD2_ENST00000395287.1_Frame_Shift_Ins_p.NP787fs|BRD2_ENST00000374831.4_Frame_Shift_Ins_p.NP752fs			P25440	BRD2_HUMAN	bromodomain containing 2	752	ET.|Poly-Ser.|Ser-rich.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						CTACTAAAAAGCCCCCCAAGAA	0.426													9	240	---	---	---	---					
KIAA1919	91749	broad.mit.edu	37	6	111587105	111587106	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:111587105_111587106insG	ENST00000368847.4	+	4	693_694	c.340_341insG	c.(340-342)gggfs	p.G114fs		NM_153369.2	NP_699200.2	Q5TF39	NAGT1_HUMAN	KIAA1919	114					carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			large_intestine(3)|lung(2)|ovary(4)|skin(3)	12		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		CTTGGCTATTTGGGGGGACAAA	0.416													7	312	---	---	---	---					
KIAA0408	9729	broad.mit.edu	37	6	127767595	127767596	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:127767595_127767596insC	ENST00000483725.3	-	5	2204_2205	c.1868_1869insG	c.(1867-1869)gcafs	p.A623fs	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	623							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TCACTTCCTGTCCCCCCCACAC	0.401													22	456	---	---	---	---					
LPAL2	80350	broad.mit.edu	37	6	160931971	160931972	+	RNA	INS	-	-	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr6:160931971_160931972insA	ENST00000335388.5	-	0	166					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		AATTATTACACAAAAAAAACTA	0.322													7	175	---	---	---	---					
PMS2CL	441194	broad.mit.edu	37	7	6759412	6759413	+	RNA	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:6759412_6759413insG	ENST00000486256.1	+	0	346					NR_002217.1																						GTGTGCCTCCCGGGGGGGAGGT	0.569													7	182	---	---	---	---					
NUPL2	11097	broad.mit.edu	37	7	23224772	23224773	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:23224772_23224773insG	ENST00000258742.5	+	2	464_465	c.205_206insG	c.(205-207)gggfs	p.G69fs	NUPL2_ENST00000487595.1_3'UTR|NUPL2_ENST00000410002.3_Frame_Shift_Ins_p.G69fs|AC005082.1_ENST00000366347.4_Intron	NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	69					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATCCACACCATGGGGGGGCAGC	0.406													13	200	---	---	---	---					
OSBPL3	26031	broad.mit.edu	37	7	24870394	24870395	+	Frame_Shift_Ins	INS	-	-	A	rs35793413		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:24870394_24870395insA	ENST00000313367.2	-	16	2327_2328	c.1876_1877insT	c.(1876-1878)agafs	p.R626fs	OSBPL3_ENST00000396429.1_Frame_Shift_Ins_p.R590fs|OSBPL3_ENST00000431825.2_Frame_Shift_Ins_p.R559fs|OSBPL3_ENST00000396431.1_Frame_Shift_Ins_p.R595fs|OSBPL3_ENST00000352860.1_Frame_Shift_Ins_p.R595fs|OSBPL3_ENST00000353930.1_Frame_Shift_Ins_p.R590fs|OSBPL3_ENST00000409069.1_Frame_Shift_Ins_p.R559fs	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	626					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						TACCTGTTCTGAAAAAAACTGG	0.421													13	1314	---	---	---	---					
FKBP9	11328	broad.mit.edu	37	7	33014803	33014804	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:33014803_33014804insC	ENST00000242209.4	+	3	546_547	c.377_378insC	c.(376-378)accfs	p.T126fs	FKBP9_ENST00000538443.1_5'UTR|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538336.1_Frame_Shift_Ins_p.T179fs	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	126	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			GCTGGTGTGATCCCCCCCAATT	0.446													12	382	---	---	---	---					
C7orf57	136288	broad.mit.edu	37	7	48089565	48089566	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:48089565_48089566insC	ENST00000348904.3	+	6	808_809	c.596_597insC	c.(595-597)tccfs	p.S199fs	C7orf57_ENST00000420324.1_Frame_Shift_Ins_p.S244fs|C7orf57_ENST00000435376.1_Frame_Shift_Ins_p.S77fs|C7orf57_ENST00000539619.1_Frame_Shift_Ins_p.S199fs|C7orf57_ENST00000430738.1_Frame_Shift_Ins_p.S244fs	NM_001100159.2	NP_001093629.1	Q8NEG2	CG057_HUMAN	chromosome 7 open reading frame 57	199										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	9						AGACTCTCCTTCCCCCCCGTGT	0.550													7	229	---	---	---	---					
RP11-368M16.3	0	broad.mit.edu	37	7	57698565	57698566	+	RNA	INS	-	-	TGGG			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:57698565_57698566insTGGG	ENST00000605139.1	-	0	416																											CACAGGAGACCTGGGCTGCAGG	0.584													3	3	---	---	---	---					
ZNF107	51427	broad.mit.edu	37	7	64169016	64169017	+	In_Frame_Ins	INS	-	-	GAA			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:64169016_64169017insGAA	ENST00000395391.1	+	4	3709_3710	c.2334_2335insGAA	c.(2332-2337)tgagta>tgGAAagta	p.778_778*>WK	ZNF107_ENST00000344930.3_In_Frame_Ins_p.778_778*>WK|ZNF107_ENST00000423627.1_In_Frame_Ins_p.778_778*>WK			Q9UII5	ZN107_HUMAN	zinc finger protein 107	778					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CCTACAAATGTGAGTATGGCAA	0.351													10	26	---	---	---	---					
RP11-3P22.2	0	broad.mit.edu	37	7	68719820	68719831	+	RNA	DEL	AAGGAAGAGAGA	AAGGAAGAGAGA	-	rs73143711	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:68719820_68719831delAAGGAAGAGAGA	ENST00000435148.1	-	0	590																											ggaagagaggaaggaagagagaaaggaagaga	0.448													2	4	---	---	---	---					
DTX2	113878	broad.mit.edu	37	7	76112242	76112243	+	Frame_Shift_Ins	INS	-	-	C	rs143934697		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:76112242_76112243insC	ENST00000324432.5	+	5	1196_1197	c.686_687insC	c.(685-687)cccfs	p.P229fs	DTX2_ENST00000413936.2_Frame_Shift_Ins_p.P229fs|DTX2_ENST00000446820.2_Frame_Shift_Ins_p.P229fs|DTX2_ENST00000446600.1_Frame_Shift_Ins_p.P138fs|DTX2_ENST00000430490.2_Frame_Shift_Ins_p.P229fs|DTX2_ENST00000307569.8_Frame_Shift_Ins_p.P229fs	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	229					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						GTCCCCCAGCACCCCCCACACA	0.649													7	250	---	---	---	---					
TRRAP	8295	broad.mit.edu	37	7	98592294	98592295	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:98592294_98592295insC	ENST00000359863.4	+	66	10299_10300	c.10090_10091insC	c.(10090-10092)cccfs	p.P3364fs	TRRAP_ENST00000446306.3_Frame_Shift_Ins_p.P3353fs|TRRAP_ENST00000355540.3_Frame_Shift_Ins_p.P3335fs	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3364					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTAAAATCACCCCCCACACT	0.540													8	655	---	---	---	---					
SPDYE3	441272	broad.mit.edu	37	7	99912173	99912174	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:99912173_99912174insC	ENST00000332397.6	+	6	1185_1186	c.1001_1002insC	c.(1000-1002)accfs	p.T334fs	SPDYE3_ENST00000437326.2_5'UTR	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	334										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						GTAGATCCCAGCCCCCCGCGTA	0.569													13	413	---	---	---	---					
ZCWPW1	55063	broad.mit.edu	37	7	100000150	100000151	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:100000150_100000151insT	ENST00000398027.2	-	16	1706_1707	c.1459_1460insA	c.(1459-1461)caafs	p.Q487fs	ZCWPW1_ENST00000360951.4_Intron|ZCWPW1_ENST00000490721.1_Frame_Shift_Ins_p.Q367fs|ZCWPW1_ENST00000324725.6_Frame_Shift_Ins_p.Q367fs	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	487							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTTGGCTTGGTTTTTTGGGTC	0.480													10	3350	---	---	---	---					
PCOLCE	5118	broad.mit.edu	37	7	100205413	100205414	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:100205413_100205414insC	ENST00000223061.5	+	8	1446_1447	c.1166_1167insC	c.(1165-1167)tccfs	p.S389fs		NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	389	NTR.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity	p.M392fs*>59(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TGCAAGCAGTGCCCCCCCATGA	0.510													8	173	---	---	---	---					
AP1S1	1174	broad.mit.edu	37	7	100802404	100802405	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:100802404_100802405insG	ENST00000337619.5	+	4	474_475	c.356_357insG	c.(355-357)aggfs	p.R119fs		NM_001283.3	NP_001274.1	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1 subunit	119					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)	8	Lung NSC(181;0.168)|all_lung(186;0.215)					GAGTTTTTGATGGGGGGGGATG	0.564													13	136	---	---	---	---					
GRM8	2918	broad.mit.edu	37	7	126173277	126173278	+	Frame_Shift_Ins	INS	-	-	G	rs77499554		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:126173277_126173278insG	ENST00000339582.2	-	9	2966_2967	c.2158_2159insC	c.(2158-2160)catfs	p.H720fs	GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Frame_Shift_Ins_p.H720fs|GRM8_ENST00000358373.3_Frame_Shift_Ins_p.H720fs			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	720					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AATGATGATGTGGGGGGGATCC	0.505										HNSCC(24;0.065)			8	130	---	---	---	---					
CCDC136	64753	broad.mit.edu	37	7	128457829	128457830	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:128457829_128457830insC	ENST00000297788.4	+	17	3748_3749	c.3381_3382insC	c.(3379-3384)aaccccfs	p.NP1127fs	CCDC136_ENST00000471729.1_Intron|CCDC136_ENST00000487361.1_Frame_Shift_Ins_p.NP488fs|CCDC136_ENST00000464832.1_Frame_Shift_Ins_p.NP419fs|CCDC136_ENST00000378685.4_Frame_Shift_Ins_p.NP407fs	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	1127						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						CTACCCCCAATCCCCCCATCTT	0.520													8	1688	---	---	---	---					
TRPV5	56302	broad.mit.edu	37	7	142612493	142612494	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr7:142612493_142612494insC	ENST00000265310.1	-	10	1617_1618	c.1269_1270insG	c.(1267-1272)ggcattfs	p.I424fs		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	424					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					ACATGGAATGGCCCCCCAAGAA	0.505													11	755	---	---	---	---					
MYOM2	9172	broad.mit.edu	37	8	2088682	2088683	+	Frame_Shift_Ins	INS	-	-	G	rs34620424	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:2088682_2088683insG	ENST00000262113.4	+	33	3978_3979	c.3837_3838insG	c.(3835-3840)atggggfs	p.MG1279fs	MYOM2_ENST00000520298.1_3'UTR|MYOM2_ENST00000523438.1_Frame_Shift_Ins_p.MG704fs	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1279					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ATATGAGAATCGGGGGGAGTGA	0.446													7	418	---	---	---	---					
SLC18A1	6570	broad.mit.edu	37	8	20004787	20004788	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:20004787_20004788insG	ENST00000440926.1	-	16	1915_1916	c.1445_1446insC	c.(1444-1446)cgcfs	p.R482fs	SLC18A1_ENST00000437980.1_Intron|SLC18A1_ENST00000381608.4_Intron|SLC18A1_ENST00000519026.1_Frame_Shift_Ins_p.R450fs|SLC18A1_ENST00000265808.7_Frame_Shift_Ins_p.R450fs|SLC18A1_ENST00000276373.5_Frame_Shift_Ins_p.R482fs	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	482					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		CTTCCTTTGCCGGGGGGCTCCG	0.500													7	388	---	---	---	---					
DMTN	2039	broad.mit.edu	37	8	21926551	21926552	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:21926551_21926552insC	ENST00000358242.3	+	5	767_768	c.274_275insC	c.(274-276)cccfs	p.P92fs	DMTN_ENST00000523266.1_Frame_Shift_Ins_p.P92fs|DMTN_ENST00000517600.1_Intron|DMTN_ENST00000523782.2_Frame_Shift_Ins_p.P67fs|DMTN_ENST00000265800.5_Frame_Shift_Ins_p.P92fs|DMTN_ENST00000519907.1_Frame_Shift_Ins_p.P92fs|DMTN_ENST00000443491.2_Frame_Shift_Ins_p.P67fs|DMTN_ENST00000415253.1_Frame_Shift_Ins_p.P92fs|DMTN_ENST00000432128.1_Frame_Shift_Ins_p.P92fs|DMTN_ENST00000381470.3_Frame_Shift_Ins_p.P92fs					dematin actin binding protein																		CAAATCCACATCCCCCCCACCA	0.604													7	150	---	---	---	---					
NUGGC	389643	broad.mit.edu	37	8	27880848	27880849	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:27880848_27880849insG	ENST00000413272.2	-	19	2518_2519	c.2376_2377insC	c.(2374-2379)ccggacfs	p.D793fs	NUGGC_ENST00000341513.6_Frame_Shift_Ins_p.D793fs	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated									p.P792P(2)									AGTGATGTCCCGGGGGGGCCAG	0.525													7	116	---	---	---	---					
KCNU1	157855	broad.mit.edu	37	8	36768517	36768518	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:36768517_36768518insC	ENST00000399881.3	+	22	2438_2439	c.2401_2402insC	c.(2401-2403)cccfs	p.P801fs		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	801						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TGCTGTCTTGTCCCCCCCACCC	0.525													8	183	---	---	---	---					
POMK	84197	broad.mit.edu	37	8	42958728	42958729	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:42958728_42958729insC	ENST00000331373.5	+	4	292_293	c.37_38insC	c.(37-39)cccfs	p.P13fs		NM_001277971.1|NM_032237.3	NP_001264900.1|NP_115613.1	Q9H5K3	SG196_HUMAN		13						integral to membrane	ATP binding|protein kinase activity										GAGAGGCCTCGCCCCCCGAGAG	0.540													13	294	---	---	---	---					
ARFGEF1	10565	broad.mit.edu	37	8	68128855	68128856	+	Frame_Shift_Ins	INS	-	-	G	rs142098461		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:68128855_68128856insG	ENST00000262215.3	-	33	5044_5045	c.4655_4656insC	c.(4654-4656)cccfs	p.P1552fs	ARFGEF1_ENST00000518230.1_Frame_Shift_Ins_p.P390fs|ARFGEF1_ENST00000520381.1_Frame_Shift_Ins_p.P1006fs	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1552					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GAGATGGAGGTGGGGGGGCAGT	0.421													21	256	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142477454	142477463	+	RNA	DEL	CCTGGCCCTT	CCTGGCCCTT	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:142477454_142477463delCCTGGCCCTT	ENST00000430863.1	-	0	2403					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CCCTCCGCCCcctggcccttcctggccctt	0.671													3	6	---	---	---	---					
LRRC14	9684	broad.mit.edu	37	8	145746499	145746502	+	Frame_Shift_Del	DEL	TGAG	TGAG	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:145746499_145746502delTGAG	ENST00000292524.1	+	4	1265_1268	c.1119_1122delTGAG	c.(1117-1122)acfs	p.TE373fs	LRRC14_ENST00000529022.1_Frame_Shift_Del_p.TE373fs	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	373										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGGAGCTGACTGAGTGTCAGCTCG	0.593													4	6	---	---	---	---					
FREM1	158326	broad.mit.edu	37	9	14823286	14823287	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:14823286_14823287insG	ENST00000380881.4	-	14	3026_3027	c.2211_2212insC	c.(2209-2214)cctgcafs	p.A738fs	FREM1_ENST00000380880.3_Frame_Shift_Ins_p.A737fs|FREM1_ENST00000422223.2_Frame_Shift_Ins_p.A737fs			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	737					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		ATGTCTTGCATGGGGGGCATGT	0.441													10	880	---	---	---	---					
TEK	7010	broad.mit.edu	37	9	27185544	27185545	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:27185544_27185545insC	ENST00000380036.4	+	9	1686_1687	c.1244_1245insC	c.(1243-1245)cccfs	p.P415fs	TEK_ENST00000519097.1_Frame_Shift_Ins_p.P268fs|TEK_ENST00000406359.4_Frame_Shift_Ins_p.P372fs	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	415	Ig-like C2-type 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CACCGGATCCTCCCCCCTGACT	0.436													11	328	---	---	---	---					
UBAP2	55833	broad.mit.edu	37	9	33923478	33923479	+	Splice_Site	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:33923478_33923479insG	ENST00000379238.1	-	25	2914		c.e25-2		UBAP2_ENST00000360802.1_Splice_Site|UBAP2_ENST00000449054.1_Splice_Site|UBAP2_ENST00000379235.1_Splice_Site|UBAP2_ENST00000539807.1_Splice_Site|UBAP2_ENST00000379239.4_Splice_Site			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2											endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TGGAGGGACCTGGGGGGGCAAG	0.594													22	493	---	---	---	---					
FAM219A	203259	broad.mit.edu	37	9	34401027	34401028	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:34401027_34401028insG	ENST00000445726.1	-	6	798_799	c.492_493insC	c.(490-495)ccagtcfs	p.V165fs	FAM219A_ENST00000379089.1_Frame_Shift_Ins_p.V163fs|FAM219A_ENST00000297620.4_Frame_Shift_Ins_p.V148fs|FAM219A_ENST00000379081.1_Frame_Shift_Ins_p.V136fs|FAM219A_ENST00000379084.1_Splice_Site_p.P147_splice|FAM219A_ENST00000379087.1_Frame_Shift_Ins_p.V146fs|FAM219A_ENST00000379080.1_Frame_Shift_Ins_p.V152fs	NM_001184940.1|NM_001184941.1	NP_001171869.1|NP_001171870.1	Q8IW50	CI025_HUMAN	family with sequence similarity 219, member A	165																	TTCACGGACTTGGGGGGGATGA	0.644													10	102	---	---	---	---					
PIGO	84720	broad.mit.edu	37	9	35091522	35091523	+	Frame_Shift_Ins	INS	-	-	G	rs144233446		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:35091522_35091523insG	ENST00000378617.3	-	7	2755_2756	c.2361_2362insC	c.(2359-2364)cccttcfs	p.F788fs	PIGO_ENST00000361778.2_Intron|PIGO_ENST00000341666.3_Frame_Shift_Ins_p.F788fs|PIGO_ENST00000298004.5_Intron	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	788					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity	p.T788fs*5(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCTTGAGAAGTGGGGGGGCCTG	0.604													12	281	---	---	---	---					
TLN1	7094	broad.mit.edu	37	9	35720499	35720500	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:35720499_35720500insT	ENST00000314888.9	-	12	1566_1567	c.1213_1214insA	c.(1213-1215)caafs	p.Q405fs	TLN1_ENST00000540444.1_Frame_Shift_Ins_p.Q405fs	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	405	Interaction with LAYN (By similarity).				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GTGATCCTTGCTTTTTTTCTGT	0.465													8	860	---	---	---	---					
TMC1	117531	broad.mit.edu	37	9	75407208	75407209	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:75407208_75407209insT	ENST00000297784.5	+	17	2046_2047	c.1506_1507insT	c.(1504-1509)ccttttfs	p.PF502fs	TMC1_ENST00000486417.1_3'UTR|TMC1_ENST00000340019.3_Frame_Shift_Ins_p.PF502fs|TMC1_ENST00000396237.3_Frame_Shift_Ins_p.PF502fs	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	502					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						CTGGACCACCCTTTTTTGTTCA	0.441													8	945	---	---	---	---					
TRPM6	140803	broad.mit.edu	37	9	77377691	77377692	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:77377691_77377692insC	ENST00000451710.3	-	26	4132_4133	c.3895_3896insG	c.(3895-3897)actfs	p.T1299fs	TRPM6_ENST00000361255.3_Frame_Shift_Ins_p.T1294fs|TRPM6_ENST00000360774.1_Frame_Shift_Ins_p.T1299fs|TRPM6_ENST00000449912.2_Frame_Shift_Ins_p.T1294fs|TRPM6_ENST00000376864.4_Frame_Shift_Ins_p.T1299fs|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1299					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CTCAAGAAGTGCCCCCCTCTGC	0.480													8	367	---	---	---	---					
DAPK1	1612	broad.mit.edu	37	9	90321801	90321802	+	Frame_Shift_Ins	INS	-	-	G	rs56169226		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:90321801_90321802insG	ENST00000469640.2	+	27	4265_4266	c.3890_3891insG	c.(3889-3891)aggfs	p.R1297fs	DAPK1_ENST00000472284.1_Frame_Shift_Ins_p.R1272fs|DAPK1_ENST00000358077.5_Frame_Shift_Ins_p.R1272fs|DAPK1_ENST00000491893.1_Frame_Shift_Ins_p.R1206fs|DAPK1_ENST00000408954.3_Frame_Shift_Ins_p.R1272fs			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1272					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity	p.Y1276fs*31(1)|p.Y1275fs*31(1)		breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						ACCAACACCATGGGGGGGTACA	0.584									Chronic Lymphocytic Leukemia, Familial Clustering of				13	199	---	---	---	---					
C9orf152	401546	broad.mit.edu	37	9	112963553	112963554	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:112963553_112963554insG	ENST00000400613.4	-	2	1003_1004	c.394_395insC	c.(394-396)ggafs	p.G132fs	C9orf152_ENST00000473442.1_Intron	NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	132										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						ACTGGTGTCCTGGGGGGAGGTT	0.564													14	952	---	---	---	---					
NUP214	8021	broad.mit.edu	37	9	134073007	134073008	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:134073007_134073008insC	ENST00000359428.5	+	29	4270_4271	c.4126_4127insC	c.(4126-4128)cccfs	p.P1376fs	NUP214_ENST00000465486.2_3'UTR|NUP214_ENST00000451030.1_Frame_Shift_Ins_p.P1377fs|NUP214_ENST00000411637.2_Frame_Shift_Ins_p.P1366fs|NUP214_ENST00000483497.2_Frame_Shift_Ins_p.P202fs			P35658	NU214_HUMAN	nucleoporin 214kDa	1376	11 X 5 AA approximate repeats.|Pro/Ser/Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TAATTTTACTGCCCCCCCGGTG	0.545			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								8	198	---	---	---	---					
ZMYND19	116225	broad.mit.edu	37	9	140481541	140481542	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr9:140481541_140481542insC	ENST00000298585.2	-	4	462_463	c.236_237insG	c.(235-237)ggtfs	p.G79fs	ZMYND19_ENST00000471957.1_5'UTR	NM_138462.2	NP_612471.1	Q96E35	ZMY19_HUMAN	zinc finger, MYND-type containing 19	79						Golgi apparatus|plasma membrane	zinc ion binding	p.V80fs*34(2)		endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		CCGGGGCCACGCCCCCCCGGTG	0.634													14	237	---	---	---	---					
PHYH	5264	broad.mit.edu	37	10	13325834	13325835	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr10:13325834_13325835insC	ENST00000396920.3	-	7	1036_1037	c.632_633insG	c.(631-633)ggtfs	p.G211fs	PHYH_ENST00000263038.4_Frame_Shift_Ins_p.G228fs|PHYH_ENST00000396913.2_Frame_Shift_Ins_p.G128fs			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	228					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TTTTGTTAACTCCCCCCTAGAA	0.465													8	631	---	---	---	---					
SEC24C	9632	broad.mit.edu	37	10	75525559	75525560	+	Splice_Site	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr10:75525559_75525560insC	ENST00000339365.2	+	11	1530_1531	c.1366_splice	c.e11-1	p.VP456_splice	SEC24C_ENST00000345254.4_Splice_Site_p.VP456_splice|SEC24C_ENST00000411652.2_Splice_Site_p.VP337_splice|SEC24C_ENST00000535742.1_Intron|SEC24C_ENST00000546025.1_Intron|SEC24C_ENST00000540668.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	456					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					TTCCCACAGTTCCCCCCCAGTA	0.510													21	487	---	---	---	---					
BTRC	8945	broad.mit.edu	37	10	103310572	103310573	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr10:103310572_103310573insC	ENST00000370187.3	+	14	1891_1892	c.1773_1774insC	c.(1771-1776)gaccccfs	p.DP591fs	BTRC_ENST00000393441.4_Frame_Shift_Ins_p.DP550fs|BTRC_ENST00000408038.2_Frame_Shift_Ins_p.DP555fs|BTRC_ENST00000493877.1_3'UTR	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	591					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CCCAAGCTGAACCCCCCCGTTC	0.431													11	312	---	---	---	---					
OR52B6	340980	broad.mit.edu	37	11	5602545	5602546	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:5602545_5602546insC	ENST00000345043.2	+	1	439_440	c.439_440insC	c.(439-441)cccfs	p.P147fs	HBG2_ENST00000380259.2_Intron|AC015691.13_ENST00000394793.2_RNA	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCATCTGCTCCCCCCTGCGA	0.510													19	791	---	---	---	---					
APIP	51074	broad.mit.edu	37	11	34904908	34904909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:34904908_34904909insC	ENST00000395787.3	-	6	818_819	c.604_605insG	c.(604-606)aacfs	p.N202fs	APIP_ENST00000527830.1_5'UTR|APIP_ENST00000278359.5_Frame_Shift_Ins_p.N219fs	NM_015957.2	NP_057041.2	Q96GX9	MTNB_HUMAN	APAF1 interacting protein	202					apoptosis|L-methionine salvage	cytoplasm	identical protein binding|metal ion binding|methylthioribulose 1-phosphate dehydratase activity			kidney(2)|lung(1)|skin(1)	4	all_epithelial(35;0.161)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.000425)			CTCCCATGTTTCCCCCCACACA	0.450													7	365	---	---	---	---					
DDB1	1642	broad.mit.edu	37	11	61094367	61094368	+	Splice_Site	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:61094367_61094368insG	ENST00000301764.7	-	5	947		c.e5-2		DDB1_ENST00000545930.1_Splice_Site|DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa						cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						CTGAGGGTCCTGGGGGGGAAAG	0.515								Nucleotide excision repair (NER)					9	262	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65271172	65271173	+	RNA	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:65271172_65271173insG	ENST00000534336.1	+	0	5940_5941					NR_002819.2																						GGGGCAATCTTGGGGGGGATTC	0.347													7	93	---	---	---	---					
RSF1	51773	broad.mit.edu	37	11	77412023	77412024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:77412023_77412024insG	ENST00000308488.6	-	6	2552_2553	c.2250_2251insC	c.(2248-2253)ccaagtfs	p.S751fs	RSF1_ENST00000360355.2_Frame_Shift_Ins_p.S720fs|RSF1_ENST00000480887.1_Frame_Shift_Ins_p.S499fs			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	751					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TCTAGAACTTTGGGGGGAGAAT	0.411													14	449	---	---	---	---					
NCAM1	4684	broad.mit.edu	37	11	113076860	113076861	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:113076860_113076861insG	ENST00000316851.7	+	4	556_557	c.556_557insG	c.(556-558)gggfs	p.G186fs	NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000533760.1_Frame_Shift_Ins_p.G78fs|NCAM1_ENST00000401611.2_Frame_Shift_Ins_p.G195fs	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	196	Ig-like C2-type 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AATCCTGGCACGGGGGGAGATC	0.495													9	570	---	---	---	---					
VSIG2	23584	broad.mit.edu	37	11	124620739	124620740	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:124620739_124620740insG	ENST00000403470.1	-	3	352_353	c.297_298insC	c.(295-300)cccagtfs	p.S100fs	VSIG2_ENST00000326621.5_Frame_Shift_Ins_p.S100fs			Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	100	Ig-like V-type.					integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		ACCCCCACTGTGGGGGGGTTCT	0.540													7	54	---	---	---	---					
ADAMTS8	11095	broad.mit.edu	37	11	130275723	130275724	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr11:130275723_130275724insG	ENST00000257359.6	-	9	3105_3106	c.2399_2400insC	c.(2398-2400)caafs	p.Q800fs		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	800	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		ATTTGACTTTTGGGGGGAAGAC	0.579													10	780	---	---	---	---					
EFCAB4B	84766	broad.mit.edu	37	12	3788266	3788267	+	Splice_Site	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:3788266_3788267insG	ENST00000440314.2	-	6	814		c.e6-2		EFCAB4B_ENST00000444507.1_Splice_Site|EFCAB4B_ENST00000252322.1_Splice_Site	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B						activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			AGAAGTGACCTGGGGGGTGCAG	0.525													7	341	---	---	---	---					
VWF	7450	broad.mit.edu	37	12	6091108	6091109	+	Frame_Shift_Ins	INS	-	-	G	rs61750632		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:6091108_6091109insG	ENST00000261405.5	-	42	7384_7385	c.7130_7131insC	c.(7129-7131)ccafs	p.P2377fs		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2377					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding	p.P2377P(1)		NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GCAAACGGTGCGGGGGGCAGGA	0.604													9	464	---	---	---	---					
VWF	7450	broad.mit.edu	37	12	6153463	6153464	+	Frame_Shift_Ins	INS	-	-	G	rs137990643	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:6153463_6153464insG	ENST00000261405.5	-	18	2689_2690	c.2435_2436insC	c.(2434-2436)cggfs	p.R812fs		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	812	E1.|TIL 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TCACCATGCCCGGGGGGCAGAG	0.594													8	274	---	---	---	---					
CD4	920	broad.mit.edu	37	12	6924042	6924043	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:6924042_6924043insG	ENST00000011653.4	+	5	749_750	c.491_492insG	c.(490-492)cggfs	p.R164fs	CD4_ENST00000541982.1_Frame_Shift_Ins_p.R109fs|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	164	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				AAAAACATACAGGGGGGGAAGA	0.564													24	591	---	---	---	---					
ATN1	1822	broad.mit.edu	37	12	7045699	7045700	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:7045699_7045700insC	ENST00000356654.4	+	5	1506_1507	c.1269_1270insC	c.(1267-1272)caccccfs	p.HP423fs	ATN1_ENST00000396684.2_Frame_Shift_Ins_p.HP423fs	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	423					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						TCTCCAATCAGCCCCCCAAGTA	0.614													8	458	---	---	---	---					
C1S	716	broad.mit.edu	37	12	7171652	7171653	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:7171652_7171653insC	ENST00000406697.1	+	8	1101_1102	c.473_474insC	c.(472-474)tccfs	p.S158fs	C1S_ENST00000402681.3_5'UTR|C1S_ENST00000360817.5_Frame_Shift_Ins_p.S158fs|C1S_ENST00000328916.3_Frame_Shift_Ins_p.S158fs			P09871	C1S_HUMAN	complement component 1, s subcomponent	158	EGF-like; calcium-binding.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TTCTGCTCCTGCCCCCCGGAAT	0.455													12	620	---	---	---	---					
PRB1	5542	broad.mit.edu	37	12	11506229	11506231	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:11506229_11506231delTGC	ENST00000500254.2	-	4	444_446	c.407_409delGCA	c.(406-411)aag>a	p.SK136del	PRB1_ENST00000546254.1_In_Frame_Del_p.SK136del|PRB1_ENST00000545626.1_In_Frame_Del_p.SK116del	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	330	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in allele M).|Missing (in allele S).|Missing (in clone CP-4).|Missing (in clone CP-5).			extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTTGGGACTTGCTGCCTCCTTG	0.596													32	626	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546135	11546137	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:11546135_11546137delTGC	ENST00000389362.4	-	3	910_912	c.875_877delGCA	c.(874-879)aag>a	p.SK292del	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTCGGGACTTGCTGCCTCCTTG	0.606													16	1096	---	---	---	---					
HEBP1	50865	broad.mit.edu	37	12	13142224	13142225	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:13142224_13142225insC	ENST00000536942.1	-	2	353_354	c.203_204insG	c.(202-204)gacfs	p.D68fs	HEBP1_ENST00000014930.4_Frame_Shift_Ins_p.D68fs			Q9NRV9	HEBP1_HUMAN	heme binding protein 1	68					circadian rhythm	extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	7		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		TGTCATTGGTGCCCCCCGCATA	0.554													27	1203	---	---	---	---					
GRIN2B	2904	broad.mit.edu	37	12	14019043	14019044	+	Frame_Shift_Ins	INS	-	-	G	rs77738206		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:14019043_14019044insG	ENST00000279593.3	-	2	308_309	c.99_100insC	c.(97-102)ccgcatfs	p.H34fs		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	34					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCCAATGCTGGGGGGGCTCT	0.589													11	193	---	---	---	---					
WBP11	51729	broad.mit.edu	37	12	14940365	14940366	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:14940365_14940366insG	ENST00000261167.2	-	12	1792_1793	c.1559_1560insC	c.(1558-1560)cggfs	p.R520fs	WBP11_ENST00000537574.1_Frame_Shift_Ins_p.R486fs	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	520	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding	p.G521fs*28(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						GGAACAGCCCAGGGGGGGCAGG	0.550													9	238	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49445525	49445526	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:49445525_49445526insG	ENST00000301067.7	-	10	1939_1940	c.1940_1941insC	c.(1939-1941)cccfs	p.P647fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		ATACCTCAGGTGGGGGGGACAT	0.634													13	261	---	---	---	---					
TROAP	10024	broad.mit.edu	37	12	49724676	49724677	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:49724676_49724677insC	ENST00000551245.1	+	13	2159_2160	c.2048_2049insC	c.(2047-2049)accfs	p.T683fs	TROAP_ENST00000547923.1_Frame_Shift_Ins_p.T362fs|TROAP_ENST00000257909.3_Frame_Shift_Ins_p.T683fs			Q12815	TROAP_HUMAN	trophinin associated protein	683	Cys-rich.				cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CTTTGTGCCAGCCCCCCTATCT	0.569													8	521	---	---	---	---					
KRT79	338785	broad.mit.edu	37	12	53215777	53215778	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:53215777_53215778insC	ENST00000330553.5	-	9	1520_1521	c.1486_1487insG	c.(1486-1488)cacfs	p.H496fs		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	496	Tail.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACCCTTGGTGGCCCCCCCACTC	0.619													7	128	---	---	---	---					
AMHR2	269	broad.mit.edu	37	12	53819644	53819645	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:53819644_53819645insG	ENST00000257863.4	+	6	873_874	c.793_794insG	c.(793-795)gggfs	p.G265fs	AMHR2_ENST00000550311.1_Frame_Shift_Ins_p.G265fs|AMHR2_ENST00000379791.3_Frame_Shift_Ins_p.G265fs	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	265	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding	p.R265W(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	CACTGCCAGCCGGGGGGGTCCT	0.579													8	134	---	---	---	---					
PCBP2	5094	broad.mit.edu	37	12	53856277	53856278	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:53856277_53856278insC	ENST00000603815.1	+	8	867_868	c.517_518insC	c.(517-519)cccfs	p.P173fs	PCBP2_ENST00000359282.5_Splice_Site_p.P169_splice|PCBP2_ENST00000552819.1_Frame_Shift_Ins_p.P173fs|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000552296.2_Splice_Site_p.P169_splice|PCBP2_ENST00000549863.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000548933.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000359462.5_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000546463.1_Splice_Site_p.P169_splice|PCBP2_ENST00000541275.1_Splice_Site_p.P169_splice|PCBP2_ENST00000455667.3_Splice_Site_p.P169_splice|PCBP2_ENST00000447282.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000439930.3_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000437231.1_Splice_Site_p.P169_splice	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	173					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TCTCTCCCAGTCCCCCCCGAAG	0.500													14	239	---	---	---	---					
TARBP2	6895	broad.mit.edu	37	12	53898183	53898184	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:53898183_53898184insC	ENST00000266987.2	+	5	908_909	c.425_426insC	c.(424-426)accfs	p.T142fs	TARBP2_ENST00000456234.2_Frame_Shift_Ins_p.T121fs|TARBP2_ENST00000552857.1_Frame_Shift_Ins_p.T51fs|TARBP2_ENST00000394357.2_Frame_Shift_Ins_p.T121fs	NM_134323.1	NP_599150.1	Q15633	TRBP2_HUMAN	TAR (HIV-1) RNA binding protein 2	142					miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)	10						TCCTTCAGGAGCCCCCCCATGG	0.564													7	136	---	---	---	---					
OR6C4	341418	broad.mit.edu	37	12	55945453	55945454	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:55945453_55945454insG	ENST00000394256.2	+	1	471_472	c.443_444insG	c.(442-444)tggfs	p.W148fs	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						TGCTCCTGGTTGGGGGGATTCC	0.455													11	462	---	---	---	---					
DNAJC14	85406	broad.mit.edu	37	12	56222209	56222210	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:56222209_56222210insG	ENST00000357606.3	-	3	522_523	c.233_234insC	c.(232-234)cggfs	p.R78fs	DNAJC14_ENST00000317269.3_Frame_Shift_Ins_p.R78fs|DNAJC14_ENST00000317287.5_Frame_Shift_Ins_p.R78fs			Q6Y2X3	DJC14_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 14	78					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			breast(2)|kidney(1)|large_intestine(8)|lung(7)|ovary(3)|prostate(1)|skin(1)	23						CTGGACCCCCTGGGGGGCCATG	0.559													9	453	---	---	---	---					
DGKA	1606	broad.mit.edu	37	12	56347513	56347514	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:56347513_56347514insC	ENST00000331886.5	+	24	2623_2624	c.2169_2170insC	c.(2167-2172)ccccccfs	p.PP723fs	DGKA_ENST00000394147.1_Frame_Shift_Ins_p.PP723fs|DGKA_ENST00000551156.1_Frame_Shift_Ins_p.PP723fs|DGKA_ENST00000549079.2_3'UTR	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	723					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	TCATGGGCCCACCCCCCCGCTC	0.579													13	357	---	---	---	---					
ERBB3	2065	broad.mit.edu	37	12	56490961	56490962	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:56490961_56490962insG	ENST00000267101.3	+	20	2847_2848	c.2407_2408insG	c.(2407-2409)gggfs	p.G803fs	ERBB3_ENST00000450146.2_Frame_Shift_Ins_p.G160fs|ERBB3_ENST00000553131.1_Frame_Shift_Ins_p.G44fs|ERBB3_ENST00000415288.2_Frame_Shift_Ins_p.G744fs	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	803	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GAGACAACACCGGGGGGCACTG	0.540													8	236	---	---	---	---					
NACA	4666	broad.mit.edu	37	12	57114417	57114418	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:57114417_57114418insG	ENST00000454682.1	-	3	1177_1178	c.896_897insC	c.(895-897)cgafs	p.R299fs	NACA_ENST00000356769.3_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000550952.1_Frame_Shift_Ins_p.R299fs|NACA_ENST00000548563.1_Intron|NACA_ENST00000552540.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGGAAAATCTGGGGGGGTGTT	0.490			T	BCL6	NHL								7	120	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57572241	57572242	+	Frame_Shift_Ins	INS	-	-	G	rs139915490		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:57572241_57572242insG	ENST00000243077.3	+	27	4927_4928	c.4461_4462insG	c.(4459-4464)taggggfs	p.*G1487fs		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1487					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGACGCTGTACGGGGGGGAGGT	0.589													9	242	---	---	---	---					
GLI1	2735	broad.mit.edu	37	12	57860074	57860075	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:57860074_57860075insG	ENST00000228682.2	+	8	905_906	c.814_815insG	c.(814-816)gggfs	p.G272fs	GLI1_ENST00000543426.1_Frame_Shift_Ins_p.G144fs|GLI1_ENST00000546141.1_Frame_Shift_Ins_p.G231fs	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	272					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			CGTGTGCCACTGGGGGGGCTGC	0.599													50	895	---	---	---	---					
DCTN2	10540	broad.mit.edu	37	12	57927805	57927806	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:57927805_57927806insG	ENST00000548249.1	-	7	866_867	c.599_600insC	c.(598-600)cgafs	p.R200fs	DCTN2_ENST00000434715.3_Frame_Shift_Ins_p.R205fs|DCTN2_ENST00000543672.1_Frame_Shift_Ins_p.R205fs|DCTN2_ENST00000537439.1_Frame_Shift_Ins_p.R177fs	NM_001261412.1|NM_001261413.1	NP_001248341.1|NP_001248342.1	Q13561	DCTN2_HUMAN	dynactin 2 (p50)	200					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|upper_aerodigestive_tract(2)	11						GGCTGCTATCTGGGGGGGTCCC	0.500													11	230	---	---	---	---					
TMCC3	57458	broad.mit.edu	37	12	94975857	94975858	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:94975857_94975858insG	ENST00000261226.4	-	2	666_667	c.535_536insC	c.(535-537)ttgfs	p.L179fs	TMCC3_ENST00000551457.1_Frame_Shift_Ins_p.L148fs	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	179						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						CTCCATGCAATGGGGGGCAGTT	0.495													11	733	---	---	---	---					
MYBPC1	4604	broad.mit.edu	37	12	102057273	102057274	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:102057273_102057274insC	ENST00000549145.1	+	21	2355_2356	c.2255_2256insC	c.(2254-2256)cccfs	p.P752fs	MYBPC1_ENST00000541119.1_Frame_Shift_Ins_p.P727fs|MYBPC1_ENST00000536007.1_Frame_Shift_Ins_p.P720fs|MYBPC1_ENST00000392934.3_Frame_Shift_Ins_p.P726fs|MYBPC1_ENST00000545503.2_Frame_Shift_Ins_p.P739fs|MYBPC1_ENST00000452455.2_Frame_Shift_Ins_p.P739fs|MYBPC1_ENST00000361466.2_Frame_Shift_Ins_p.P764fs|MYBPC1_ENST00000361685.2_Frame_Shift_Ins_p.P764fs|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000360610.2_Frame_Shift_Ins_p.P739fs|MYBPC1_ENST00000551300.1_Frame_Shift_Ins_p.P640fs|MYBPC1_ENST00000441232.1_Frame_Shift_Ins_p.P739fs|MYBPC1_ENST00000550270.1_Frame_Shift_Ins_p.P739fs|MYBPC1_ENST00000547509.1_Frame_Shift_Ins_p.P725fs|MYBPC1_ENST00000553190.1_Frame_Shift_Ins_p.P739fs|MYBPC1_ENST00000547405.1_Frame_Shift_Ins_p.P713fs			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	739	Fibronectin type-III 2.			Y -> H (in Ref. 3; CAD38925).	cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						ATGAGGTGGCGCCCCCCAGACC	0.436													7	328	---	---	---	---					
CORO1C	23603	broad.mit.edu	37	12	109048188	109048189	+	Splice_Site	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:109048188_109048189insG	ENST00000261401.3	-	7	923		c.e7-2		CORO1C_ENST00000421578.2_Splice_Site|CORO1C_ENST00000541050.1_Splice_Site|CORO1C_ENST00000549384.1_Intron|CORO1C_ENST00000420959.2_Splice_Site|CORO1C_ENST00000549772.1_Splice_Site	NM_001105237.2|NM_001276471.1|NM_014325.2	NP_001098707.1|NP_001263400.1|NP_055140.1	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C						actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|skin(4)	24						CATATTTTTCTGGGGGGAAGAT	0.327													8	584	---	---	---	---					
USP30	84749	broad.mit.edu	37	12	109495864	109495865	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:109495864_109495865insC	ENST00000257548.5	+	3	420_421	c.327_328insC	c.(325-330)gaccccfs	p.DP109fs	USP30_ENST00000392784.2_Frame_Shift_Ins_p.DP78fs	NM_032663.3	NP_116052.2	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	109					ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(7)|kidney(1)|large_intestine(1)|liver(2)|lung(11)|prostate(1)|skin(3)|stomach(2)	28						ATCAGAAGGAGCCCCCCTCACA	0.485													10	1672	---	---	---	---					
UBE3B	89910	broad.mit.edu	37	12	109939222	109939223	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:109939222_109939223insG	ENST00000342494.3	+	13	1760_1761	c.1165_1166insG	c.(1165-1167)gggfs	p.G389fs	UBE3B_ENST00000280774.5_Frame_Shift_Ins_p.G389fs|UBE3B_ENST00000434735.2_Frame_Shift_Ins_p.G389fs	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	389					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GCAGTTCTTGTGGGGGGTGCCT	0.554													12	342	---	---	---	---					
SLC8B1	80024	broad.mit.edu	37	12	113758305	113758306	+	Splice_Site	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:113758305_113758306insG	ENST00000552014.1	-	8	1042		c.e8-2		SLC24A6_ENST00000546737.1_Intron|SLC24A6_ENST00000202831.3_Splice_Site|SLC24A6_ENST00000553238.1_Intron			Q6J4K2	NCKX6_HUMAN							response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						CGCCAGCGCCTGGGGGGAGGAG	0.644													12	862	---	---	---	---					
KSR2	283455	broad.mit.edu	37	12	117977604	117977605	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:117977604_117977605insG	ENST00000425217.1	-	10	1573_1574	c.1519_1520insC	c.(1519-1521)cccfs	p.P507fs	KSR2_ENST00000545002.1_5'UTR|KSR2_ENST00000339824.5_Frame_Shift_Ins_p.P536fs|KSR2_ENST00000302438.5_Frame_Shift_Ins_p.P233fs	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	536					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACTAGGAGGGAGGGGGGGTGCT	0.634													11	189	---	---	---	---					
SIRT4	23409	broad.mit.edu	37	12	120750293	120750294	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:120750293_120750294insG	ENST00000202967.4	+	3	591_592	c.532_533insG	c.(532-534)gggfs	p.G178fs	SIRT4_ENST00000537892.1_Intron	NM_012240.2	NP_036372.1	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	178	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACAGACTCCCCGGGGGGTGCTG	0.579													8	362	---	---	---	---					
MSI1	4440	broad.mit.edu	37	12	120800902	120800903	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:120800902_120800903insC	ENST00000257552.2	-	6	433_434	c.345_346insG	c.(343-348)ggtgtcfs	p.V116fs		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	116	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCACCGACAGCCCCCCCACAA	0.564													19	373	---	---	---	---					
VPS33A	65082	broad.mit.edu	37	12	122720396	122720397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr12:122720396_122720397insC	ENST00000267199.4	-	11	1488_1489	c.1376_1377insG	c.(1375-1377)gagfs	p.E459fs	RP11-512M8.5_ENST00000535844.1_Frame_Shift_Ins_p.E420fs	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	459					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AATTGTTTCTGCCCCCCGTCTG	0.495													10	425	---	---	---	---					
KBTBD6	89890	broad.mit.edu	37	13	41705321	41705322	+	Frame_Shift_Ins	INS	-	-	C	rs147771080		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr13:41705321_41705322insC	ENST00000379485.1	-	1	1560_1561	c.1326_1327insG	c.(1324-1329)gggagafs	p.R443fs	KBTBD6_ENST00000499385.2_Frame_Shift_Ins_p.R377fs	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	443							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ATAGGGTCTCGCCCCCCCAAAA	0.470													16	259	---	---	---	---					
MBNL2	10150	broad.mit.edu	37	13	97928603	97928604	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr13:97928603_97928604insC	ENST00000345429.6	+	2	895_896	c.114_115insC	c.(112-117)caccccfs	p.HP38fs	MBNL2_ENST00000376673.3_Frame_Shift_Ins_p.HP38fs|MBNL2_ENST00000397601.1_Frame_Shift_Ins_p.HP38fs|MBNL2_ENST00000445661.2_Frame_Shift_Ins_p.HP38fs|MBNL2_ENST00000343600.4_Frame_Shift_Ins_p.HP38fs	NM_144778.3	NP_659002.1	Q5VZF2	MBNL2_HUMAN	muscleblind-like splicing regulator 2	38					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			AATTTGCTCATCCCCCCAAAAG	0.411													7	428	---	---	---	---					
OR4N2	390429	broad.mit.edu	37	14	20295776	20295777	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:20295776_20295777insC	ENST00000315947.1	+	1	169_170	c.169_170insC	c.(169-171)cccfs	p.P57fs	OR4N2_ENST00000568211.1_Frame_Shift_Ins_p.P57fs	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGGCTCACAGCCCCCCTCTAT	0.475													9	833	---	---	---	---					
OR4K5	79317	broad.mit.edu	37	14	20389294	20389294	+	Frame_Shift_Del	DEL	T	T	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:20389294delT	ENST00000315915.4	+	1	554	c.529delT	c.(529-531)ttfs	p.F178fs		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTAGACAGCTTTTTTTGTGA	0.423													10	1254	---	---	---	---					
OR4N5	390437	broad.mit.edu	37	14	20612063	20612064	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:20612063_20612064insC	ENST00000333629.1	+	1	169_170	c.169_170insC	c.(169-171)cccfs	p.P57fs		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGGGCTCACAGCCCCCCTCTAT	0.460													7	1531	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20846337	20846338	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:20846337_20846338insC	ENST00000262715.5	-	39	5606_5607	c.5566_5567insG	c.(5566-5568)tgtfs	p.C1856fs	TEP1_ENST00000545983.1_Frame_Shift_Ins_p.C194fs|TEP1_ENST00000556935.1_Frame_Shift_Ins_p.C1748fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1856					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CACAGCCACAACCCCCCCAGGC	0.624													7	156	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20852646	20852647	+	Frame_Shift_Ins	INS	-	-	C	rs144584331		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:20852646_20852647insC	ENST00000262715.5	-	23	3282_3283	c.3242_3243insG	c.(3241-3243)ggtfs	p.G1081fs	TEP1_ENST00000556935.1_Frame_Shift_Ins_p.G973fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1081					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding	p.V1082fs*47(1)		NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CAGCTGCCACACCCCCCCACTC	0.584													23	506	---	---	---	---					
ARHGEF40	55701	broad.mit.edu	37	14	21546603	21546604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:21546603_21546604insG	ENST00000298694.4	+	10	2329_2330	c.2202_2203insG	c.(2200-2205)gaggggfs	p.EG734fs	ARHGEF40_ENST00000298693.3_Frame_Shift_Ins_p.EG734fs			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	734					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						TGCAGAGGGATGGGGGGGCCAT	0.629													14	183	---	---	---	---					
ARHGEF40	55701	broad.mit.edu	37	14	21556191	21556192	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:21556191_21556192insC	ENST00000298694.4	+	22	4579_4580	c.4452_4453insC	c.(4450-4455)caccccfs	p.HP1484fs	ARHGEF40_ENST00000298693.3_Frame_Shift_Ins_p.HP1436fs			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	1484					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						CCAGCCTGCAACCCCCCCACCC	0.574													8	117	---	---	---	---					
SALL2	6297	broad.mit.edu	37	14	21992275	21992276	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:21992275_21992276insG	ENST00000327430.3	-	2	1880_1881	c.1586_1587insC	c.(1585-1587)cggfs	p.R529fs	SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_Frame_Shift_Ins_p.R392fs|SALL2_ENST00000538754.1_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	529							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CCTCACTCCCTGGGGGGGTGTT	0.530													13	234	---	---	---	---					
OR10G2	26534	broad.mit.edu	37	14	22102924	22102925	+	Frame_Shift_Ins	INS	-	-	G	rs150140072		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:22102924_22102925insG	ENST00000542433.1	-	1	171_172	c.74_75insC	c.(73-75)caafs	p.Q25fs		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TTCTTAGATTTGGGGGGTGAGA	0.480													8	414	---	---	---	---					
TRAC	28755	broad.mit.edu	37	14	23020674	23020675	+	RNA	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:23020674_23020675insC	ENST00000478163.3	+	0	551_552																											CCACCTCTGTGCCCCCCCGGCA	0.554													7	349	---	---	---	---					
RBM23	55147	broad.mit.edu	37	14	23371029	23371030	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:23371029_23371030insG	ENST00000359890.3	-	13	1504_1505	c.1309_1310insC	c.(1309-1311)gacfs	p.D437fs	RBM23_ENST00000555209.1_Frame_Shift_Ins_p.D187fs|RBM23_ENST00000346528.5_Frame_Shift_Ins_p.D403fs|RBM23_ENST00000542016.2_Frame_Shift_Ins_p.D267fs|RBM23_ENST00000399922.2_Frame_Shift_Ins_p.D421fs	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	437					mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		TCACATGGTCTGGGGGGTAAAG	0.505													8	1374	---	---	---	---					
GZMH	2999	broad.mit.edu	37	14	25075937	25075938	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:25075937_25075938insC	ENST00000216338.4	-	5	656_657	c.612_613insG	c.(610-615)ggccctfs	p.GP204fs	RP11-104E19.1_ENST00000555300.1_RNA|RP11-104E19.1_ENST00000557736.1_RNA|GZMH_ENST00000557220.2_Frame_Shift_Ins_p.GP73fs|GZMH_ENST00000382548.4_Frame_Shift_Ins_p.GP118fs	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	204	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		CACACGAGGGGCCCCCCGGAGT	0.535													7	312	---	---	---	---					
ABHD12B	145447	broad.mit.edu	37	14	51347189	51347190	+	Frame_Shift_Ins	INS	-	-	G	rs141865189		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:51347189_51347190insG	ENST00000337334.2	+	4	370_371	c.355_356insG	c.(355-357)gggfs	p.G119fs	ABHD12B_ENST00000554241.1_3'UTR|ABHD12B_ENST00000395752.1_Frame_Shift_Ins_p.G12fs|ABHD12B_ENST00000353130.1_Frame_Shift_Ins_p.G42fs|PYGL_ENST00000532462.1_Intron	NM_001206673.1	NP_001193602.1	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B	119							hydrolase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(5)	10	all_epithelial(31;0.00481)|Breast(41;0.148)					CCCCAGCTGCCGGGGGGAAGAT	0.490													7	393	---	---	---	---					
KCNH5	27133	broad.mit.edu	37	14	63174302	63174303	+	Frame_Shift_Ins	INS	-	-	G	rs35940222		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:63174302_63174303insG	ENST00000322893.7	-	11	3158_3159	c.2890_2891insC	c.(2890-2892)gatfs	p.D964fs	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	964					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACATGGTATCTGGGGGGGTACT	0.391													9	317	---	---	---	---					
DCAF5	8816	broad.mit.edu	37	14	69588975	69588976	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:69588975_69588976insA	ENST00000341516.5	-	2	463_464	c.316_317insT	c.(316-318)cctfs	p.P106fs	DCAF5_ENST00000389997.6_Frame_Shift_Ins_p.P106fs|DCAF5_ENST00000556847.1_Frame_Shift_Ins_p.P24fs|DCAF5_ENST00000557386.1_Frame_Shift_Ins_p.P106fs|DCAF5_ENST00000554215.1_Frame_Shift_Ins_p.P24fs	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	106						CUL4 RING ubiquitin ligase complex		p.C106fs*10(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						GAAAGCCAGGCAAAAAATGTTG	0.485													7	800	---	---	---	---					
GALNT16	57452	broad.mit.edu	37	14	69800299	69800300	+	Frame_Shift_Ins	INS	-	-	G	rs144140025		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:69800299_69800300insG	ENST00000337827.4	+	9	1276_1277	c.949_950insG	c.(949-951)gggfs	p.G317fs	GALNT16_ENST00000553669.1_Frame_Shift_Ins_p.G317fs|GALNT16_ENST00000448469.3_Frame_Shift_Ins_p.G317fs	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		GATGGACATCTGGGGGGGAGAG	0.470													7	249	---	---	---	---					
MED6	10001	broad.mit.edu	37	14	71051554	71051555	+	Frame_Shift_Ins	INS	-	-	G	rs145634622	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:71051554_71051555insG	ENST00000256379.5	-	8	745_746	c.716_717insC	c.(715-717)cgafs	p.R239fs	MED6_ENST00000554963.1_Frame_Shift_Ins_p.R239fs|MED6_ENST00000430055.2_Frame_Shift_Ins_p.R246fs|MED6_ENST00000440435.2_3'UTR	NM_005466.2	NP_005457.2	O75586	MED6_HUMAN	mediator complex subunit 6	239					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	transcription coactivator activity	p.E240fs*1(1)		large_intestine(2)|lung(2)|skin(1)	5				all cancers(60;0.00315)|BRCA - Breast invasive adenocarcinoma(234;0.00685)|OV - Ovarian serous cystadenocarcinoma(108;0.0352)		TCCGTTTTTCAGGGGGGCCTTT	0.450													10	1170	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72165808	72165809	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:72165808_72165809insG	ENST00000555818.1	+	11	3833_3834	c.3485_3486insG	c.(3484-3486)gggfs	p.G1162fs	SIPA1L1_ENST00000381232.3_Frame_Shift_Ins_p.G1162fs|SIPA1L1_ENST00000358550.2_Frame_Shift_Ins_p.G1162fs|SIPA1L1_ENST00000537413.1_Frame_Shift_Ins_p.G637fs	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1162					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACTGGTTCTGTGGGGGGCACTT	0.495													9	372	---	---	---	---					
CCDC176	80127	broad.mit.edu	37	14	74514756	74514760	+	Frame_Shift_Del	DEL	TACTT	TACTT	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:74514756_74514760delTACTT	ENST00000394009.3	+	7	894_898	c.771_775delTACTT	c.(769-777)catafs	p.HTL257fs	CCDC176_ENST00000553773.1_5'UTR|AC005484.5_ENST00000492026.1_RNA|CCDC176_ENST00000489323.1_3'UTR	NM_025057.2	NP_079333.2			coiled-coil domain containing 176																		AAGAGAGTCATACTTTACTTTTACA	0.341													9	47	---	---	---	---					
YLPM1	56252	broad.mit.edu	37	14	75248518	75248519	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:75248518_75248519insC	ENST00000325680.7	+	4	1896_1897	c.1772_1773insC	c.(1771-1773)cccfs	p.P591fs	YLPM1_ENST00000238571.3_Intron|YLPM1_ENST00000552421.1_Frame_Shift_Ins_p.P591fs	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCACCAGTTCTCCCCCCACCTT	0.599													9	571	---	---	---	---					
NRXN3	9369	broad.mit.edu	37	14	79270135	79270136	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:79270135_79270136insG	ENST00000554719.1	+	6	1589_1590	c.1098_1099insG	c.(1096-1101)gaggggfs	p.EG366fs	NRXN3_ENST00000335750.5_Frame_Shift_Ins_p.EG366fs	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	144					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGGAGCTGGATGGGGGGCGTGT	0.540													7	289	---	---	---	---					
SERPINA1	5265	broad.mit.edu	37	14	94844884	94844885	+	Frame_Shift_Ins	INS	-	-	G	rs143329723	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:94844884_94844885insG	ENST00000448921.1	-	7	1730_1731	c.1158_1159insC	c.(1156-1161)ccaggtfs	p.G387fs	SERPINA1_ENST00000404814.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000440909.1_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000393088.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000449399.3_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000393087.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000355814.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000437397.1_Frame_Shift_Ins_p.G387fs	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	387	RCL.		E -> K (in Christchurch).		acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	AACTTGACCTCGGGGGGGATAG	0.490													10	255	---	---	---	---					
IGHV4-39	28394	broad.mit.edu	37	14	106877817	106877819	+	RNA	DEL	ACT	ACT	-	rs113800876		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:106877817_106877819delACT	ENST00000390619.2	-	0	224_226																											CCCAGTAGTAACTACTACTGCTG	0.596													26	159	---	---	---	---					
OR4M2	390538	broad.mit.edu	37	15	22369023	22369024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:22369023_22369024insG	ENST00000332663.2	+	1	546_547	c.448_449insG	c.(448-450)gggfs	p.G150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R150M(2)|p.R150W(1)		NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTCTCCTGGAGGGGGGGCTTC	0.500													48	1052	---	---	---	---					
RYR3	6263	broad.mit.edu	37	15	34078053	34078054	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:34078053_34078054insC	ENST00000389232.4	+	66	9529_9530	c.9459_9460insC	c.(9457-9462)ctccccfs	p.LP3153fs	RYR3_ENST00000415757.3_Frame_Shift_Ins_p.LP3153fs	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3153					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGAGAACCTGCCCCCCAGCAC	0.564													8	605	---	---	---	---					
C15orf52	388115	broad.mit.edu	37	15	40630771	40630772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:40630771_40630772insG	ENST00000559313.1	-	5	624_625	c.609_610insC	c.(607-612)cccgcafs	p.A204fs		NM_207380.2	NP_997263.2	Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	204										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCCACCTGCGTGGGGGGGCTTC	0.584											OREG0023060	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	288	---	---	---	---					
SORD	6652	broad.mit.edu	37	15	45353365	45353366	+	Frame_Shift_Ins	INS	-	-	C	rs11542063	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:45353365_45353366insC	ENST00000267814.9	+	4	546_547	c.366_367insC	c.(364-369)acccccfs	p.TP122fs	SORD_ENST00000558580.1_Frame_Shift_Ins_p.TP101fs	NM_003104.5	NP_003095.2	Q00796	DHSO_HUMAN	sorbitol dehydrogenase	122					fructose biosynthetic process|glucose metabolic process|L-xylitol catabolic process|sorbitol catabolic process|sperm motility	cilium|extracellular space|flagellum|membrane fraction|mitochondrial membrane|soluble fraction	L-iditol 2-dehydrogenase activity|NAD binding|sugar binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(4)	9		all_cancers(109;3.43e-12)|all_epithelial(112;2.33e-10)|Lung NSC(122;6.01e-07)|all_lung(180;4.38e-06)|Melanoma(134;0.0122)		all cancers(107;1.6e-18)|GBM - Glioblastoma multiforme(94;4.95e-07)|COAD - Colon adenocarcinoma(120;0.0704)|Colorectal(133;0.0706)	NADH(DB00157)	TCTGTGCCACGCCCCCCGATGA	0.530													15	410	---	---	---	---					
WDR72	256764	broad.mit.edu	37	15	53908070	53908071	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:53908070_53908071insT	ENST00000396328.1	-	15	2571_2572	c.2332_2333insA	c.(2332-2334)gcafs	p.A778fs	WDR72_ENST00000559418.1_Frame_Shift_Ins_p.A788fs|WDR72_ENST00000360509.5_Frame_Shift_Ins_p.A778fs|WDR72_ENST00000557913.1_Frame_Shift_Ins_p.A775fs	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	778										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CTTAGGCTGCATTTTTTTGGAG	0.391													7	1112	---	---	---	---					
RFX7	64864	broad.mit.edu	37	15	56386880	56386881	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:56386880_56386881insG	ENST00000423270.1	-	9	3044_3045	c.3045_3046insC	c.(3043-3048)ccgcccfs	p.P1016fs	RFX7_ENST00000317318.6_Frame_Shift_Ins_p.P1016fs|RFX7_ENST00000422057.1_Frame_Shift_Ins_p.P919fs|RFX7_ENST00000559447.2_Frame_Shift_Ins_p.P919fs	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	919					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TCAACAGGGCTGGGGGGGACAC	0.500													7	181	---	---	---	---					
GTF2A2	2958	broad.mit.edu	37	15	59942953	59942954	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:59942953_59942954insG	ENST00000396060.2	-	3	272_273	c.91_92insC	c.(91-93)actfs	p.T31fs	GTF2A2_ENST00000267869.4_Intron|GTF2A2_ENST00000396061.1_Frame_Shift_Ins_p.T31fs|GTF2A2_ENST00000396063.1_Frame_Shift_Ins_p.T31fs|GTF2A2_ENST00000396064.3_Frame_Shift_Ins_p.T31fs|GTF2A2_ENST00000484743.1_Intron|AC092755.4_ENST00000441746.1_RNA	NM_004492.2	NP_004483.1	P52657	T2AG_HUMAN	general transcription factor IIA, 2, 12kDa	31					interspecies interaction between organisms|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIA complex	protein heterodimerization activity|protein homodimerization activity|TBP-class protein binding|transcription coactivator activity			central_nervous_system(2)|kidney(2)|lung(1)	5						AAGGGCAAGTTGGGGGGTGATC	0.376													7	231	---	---	---	---					
HERC1	8925	broad.mit.edu	37	15	63918305	63918306	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:63918305_63918306insG	ENST00000443617.2	-	71	13240_13241	c.13153_13154insC	c.(13153-13155)gtafs	p.V4385fs		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4385					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CGCCCCATACTGGGGGGGCACT	0.559													9	102	---	---	---	---					
ZNF609	23060	broad.mit.edu	37	15	64967993	64967994	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:64967993_64967994insC	ENST00000326648.3	+	4	3068_3069	c.2940_2941insC	c.(2938-2943)gtccccfs	p.VP980fs		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	980						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ATGCCTATGTACCCCCCTATGG	0.550													11	1272	---	---	---	---					
LARP6	55323	broad.mit.edu	37	15	71125256	71125257	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:71125256_71125257insG	ENST00000299213.8	-	3	680_681	c.610_611insC	c.(610-612)gaafs	p.E204fs		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	204					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						TCCATTCTTCTGGGGGGTGGCC	0.545													8	209	---	---	---	---					
ALPK3	57538	broad.mit.edu	37	15	85405928	85405929	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:85405928_85405929insG	ENST00000258888.5	+	10	4965_4966	c.4798_4799insG	c.(4798-4800)gggfs	p.G1600fs		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1600	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCTGGCTGCTGGGGGGACAAG	0.584													7	181	---	---	---	---					
IGF1R	3480	broad.mit.edu	37	15	99251108	99251109	+	Frame_Shift_Ins	INS	-	-	G	rs121912426		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:99251108_99251109insG	ENST00000268035.6	+	2	1023_1024	c.412_413insG	c.(412-414)gggfs	p.G138fs	IGF1R_ENST00000558762.1_Frame_Shift_Ins_p.G138fs	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	138			R -> Q (in IGF1RES; has decreased IGF1R function).		anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GAACATTACTCGGGGGGCCATC	0.510													10	418	---	---	---	---					
ZNF174	7727	broad.mit.edu	37	16	3452110	3452111	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:3452110_3452111insA	ENST00000268655.4	+	1	691_692	c.106_107insA	c.(106-108)aaafs	p.K36fs	ZNF174_ENST00000344823.5_Frame_Shift_Ins_p.K36fs|ZNF174_ENST00000572544.1_Frame_Shift_Ins_p.K36fs|LA16c-306E5.2_ENST00000575785.1_RNA|ZNF174_ENST00000575752.1_Frame_Shift_Ins_p.K36fs|ZNF174_ENST00000571936.1_Frame_Shift_Ins_p.K36fs	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	36					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						CCCTCCTCTGCAAAAAAACTGC	0.500													7	374	---	---	---	---					
SLX4	84464	broad.mit.edu	37	16	3634840	3634841	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:3634840_3634841insG	ENST00000294008.3	-	13	5308_5309	c.4668_4669insC	c.(4666-4671)ccaagtfs	p.S1557fs		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1557	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						ATGGGCACTTTGGGGGGCAAGT	0.500								Direct reversal of damage					12	468	---	---	---	---					
ACSM2A	123876	broad.mit.edu	37	16	20489924	20489925	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:20489924_20489925insC	ENST00000573854.1	+	10	1320_1321	c.1206_1207insC	c.(1204-1209)ctccccfs	p.LP402fs	ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000396104.2_Frame_Shift_Ins_p.LP402fs|ACSM2A_ENST00000575690.1_Frame_Shift_Ins_p.LP402fs|ACSM2A_ENST00000536134.1_Frame_Shift_Ins_p.LP174fs|ACSM2A_ENST00000417235.2_Frame_Shift_Ins_p.LP323fs|ACSM2A_ENST00000219054.6_Frame_Shift_Ins_p.LP402fs	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	402					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GCAACGTCCTGCCCCCCGGCAC	0.505													7	343	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	20966297	20966298	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:20966297_20966298insG	ENST00000261383.3	-	55	10907_10908	c.10908_10909insC	c.(10906-10911)ccaaggfs	p.R3637fs	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3637	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CGGAGCCCTTTGGGGGGCTCAT	0.510													7	458	---	---	---	---					
RRN3P1	730092	broad.mit.edu	37	16	21814059	21814060	+	RNA	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:21814059_21814060insG	ENST00000546471.1	-	0	1607																											CCTATAACAAAGGGGGGGGAAA	0.381													10	151	---	---	---	---					
ERN2	10595	broad.mit.edu	37	16	23718095	23718096	+	Frame_Shift_Ins	INS	-	-	G	rs143761786		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:23718095_23718096insG	ENST00000256797.4	-	6	778_779	c.610_611insC	c.(610-612)cctfs	p.P204fs	ERN2_ENST00000457008.2_Frame_Shift_Ins_p.P156fs	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	156					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AATGTAGAGGCGGGGGGTGGAG	0.604													8	433	---	---	---	---					
ATXN2L	11273	broad.mit.edu	37	16	28846490	28846491	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:28846490_28846491insC	ENST00000336783.4	+	19	2712_2713	c.2545_2546insC	c.(2545-2547)cccfs	p.P849fs	RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000564304.1_Frame_Shift_Ins_p.P855fs|ATXN2L_ENST00000570200.1_Frame_Shift_Ins_p.P849fs|ATXN2L_ENST00000340394.8_Frame_Shift_Ins_p.P849fs|ATXN2L_ENST00000565845.1_3'UTR|ATXN2L_ENST00000395547.2_Frame_Shift_Ins_p.P849fs|ATXN2L_ENST00000325215.6_Frame_Shift_Ins_p.P849fs|ATXN2L_ENST00000382686.4_Frame_Shift_Ins_p.P849fs	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	849						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						AGAGCAGCCTACCCCCCAAGCC	0.624													11	453	---	---	---	---					
TBX6	6911	broad.mit.edu	37	16	30100077	30100078	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:30100077_30100078insC	ENST00000553607.1	-	4	1397_1398	c.704_705insG	c.(703-705)gatfs	p.D235fs	TBX6_ENST00000279386.2_Frame_Shift_Ins_p.D235fs|TBX6_ENST00000395224.2_Frame_Shift_Ins_p.D235fs			O95947	TBX6_HUMAN	T-box 6	235					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						AGGAGGCCATGCCCCCCCAGTG	0.629													19	214	---	---	---	---					
CD2BP2	10421	broad.mit.edu	37	16	30365544	30365545	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:30365544_30365545insC	ENST00000305596.3	-	3	352_353	c.177_178insG	c.(175-180)ggccagfs	p.Q60fs	CD2BP2_ENST00000569466.1_Frame_Shift_Ins_p.Q60fs	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	60					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						TATTTGCTGGACCCCCCATCAT	0.535													7	1097	---	---	---	---					
PRSS36	146547	broad.mit.edu	37	16	31150581	31150582	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:31150581_31150582insG	ENST00000268281.4	-	15	2503_2504	c.2445_2446insC	c.(2443-2448)ccgtggfs	p.W816fs	PRSS36_ENST00000569305.1_Frame_Shift_Ins_p.W811fs|PRSS36_ENST00000418068.2_Frame_Shift_Ins_p.W713fs	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	816					proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GGGGAGCCACTGGGGGGCAGGA	0.634													7	138	---	---	---	---					
ITGAD	3681	broad.mit.edu	37	16	31422475	31422476	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:31422475_31422476insC	ENST00000389202.2	+	13	1484_1485	c.1435_1436insC	c.(1435-1437)cccfs	p.P479fs		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	479					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCTCATTGGGGCCCCCCATTAC	0.649													9	821	---	---	---	---					
C16orf87	388272	broad.mit.edu	37	16	46843530	46843531	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:46843530_46843531insT	ENST00000285697.4	-	3	591_592	c.330_331insA	c.(328-333)aaatgafs	p.*111fs	C16orf87_ENST00000564250.1_5'UTR|C16orf87_ENST00000394806.2_Intron	NM_001001436.2	NP_001001436.1	Q6PH81	CP087_HUMAN	chromosome 16 open reading frame 87	111										large_intestine(4)|urinary_tract(1)	5						TCTTCCTCATGTTTTTTGGCAG	0.351													8	1127	---	---	---	---					
C16orf70	80262	broad.mit.edu	37	16	67180988	67180989	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:67180988_67180989insC	ENST00000219139.3	+	16	1411_1412	c.1223_1224insC	c.(1222-1224)gccfs	p.A408fs	C16orf70_ENST00000569600.1_Frame_Shift_Ins_p.A408fs	NM_025187.3	NP_079463.2	Q9BSU1	CP070_HUMAN	chromosome 16 open reading frame 70	408								p.R411fs*4(1)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|skin(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		ACCCTGTATGGCCCCCCCAGGC	0.594													12	310	---	---	---	---					
DPEP2	64174	broad.mit.edu	37	16	68021467	68021468	+	Frame_Shift_Ins	INS	-	-	G	rs1133090	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:68021467_68021468insG	ENST00000412757.2	-	12	2067_2068	c.1402_1403insC	c.(1402-1404)catfs	p.H468fs	DPEP2_ENST00000572888.1_Frame_Shift_Ins_p.H468fs|DPEP2_ENST00000393847.1_Frame_Shift_Ins_p.H468fs			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	468			H -> D (in dbSNP:rs1133090).		hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TGGGGCCATGTGGGGGGAGGAC	0.545													8	445	---	---	---	---					
NFAT5	10725	broad.mit.edu	37	16	69727259	69727260	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:69727259_69727260insT	ENST00000349945.1	+	14	4801_4802	c.3249_3250insT	c.(3247-3252)gcttttfs	p.AF1083fs	NFAT5_ENST00000566899.1_Frame_Shift_Ins_p.AF1083fs|NFAT5_ENST00000567239.1_Frame_Shift_Ins_p.AF1176fs|NFAT5_ENST00000393742.2_Frame_Shift_Ins_p.AF1083fs|NFAT5_ENST00000432919.1_Frame_Shift_Ins_p.AF1177fs|NFAT5_ENST00000354436.2_Frame_Shift_Ins_p.AF1159fs	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1159					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CCCAAGAAGCATTTTTTGCAGC	0.436													7	661	---	---	---	---					
KLHDC4	54758	broad.mit.edu	37	16	87795566	87795567	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr16:87795566_87795567insG	ENST00000270583.5	-	2	237_238	c.179_180insC	c.(178-180)cccfs	p.P60fs	KLHDC4_ENST00000353170.5_Intron|KLHDC4_ENST00000347925.5_Frame_Shift_Ins_p.P60fs	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	60										breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		TTGGTGAGGGTGGGGGGCACGG	0.465													7	496	---	---	---	---					
PAFAH1B1	5048	broad.mit.edu	37	17	2583499	2583500	+	Frame_Shift_Ins	INS	-	-	G	rs113994201		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:2583499_2583500insG	ENST00000397195.5	+	10	1495_1496	c.1044_1045insG	c.(1042-1047)tcggggfs	p.SG348fs	PAFAH1B1_ENST00000451360.2_Frame_Shift_Ins_p.SG143fs|PAFAH1B1_ENST00000397193.3_3'UTR	NM_000430.3	NP_000421.1	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	348	Interaction with dynein and dynactin.				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						TGTTCCATTCTGGGGGGAAGTT	0.401													10	618	---	---	---	---					
ALOX12	239	broad.mit.edu	37	17	6903739	6903740	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:6903739_6903740insC	ENST00000251535.6	+	7	945_946	c.892_893insC	c.(892-894)cccfs	p.P298fs	RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000574377.1_Intron|AC027763.2_ENST00000399541.2_Intron|AC027763.2_ENST00000575727.1_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	298	Lipoxygenase.		A -> T.		anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						ATACCTGGCTGCCCCCCTCGTT	0.554													8	833	---	---	---	---					
EFNB3	1949	broad.mit.edu	37	17	7612855	7612856	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:7612855_7612856insC	ENST00000226091.2	+	5	1381_1382	c.984_985insC	c.(982-987)ggccccfs	p.GP328fs		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	328					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				TGCAGGATGGGCCCCCCCAGAG	0.574													7	160	---	---	---	---					
CHD3	1107	broad.mit.edu	37	17	7798764	7798765	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:7798764_7798765insC	ENST00000380358.4	+	10	1789_1790	c.1788_1789insC	c.(1786-1791)ccccccfs	p.PP596fs	CHD3_ENST00000358181.4_Frame_Shift_Ins_p.PP537fs|CHD3_ENST00000330494.7_Frame_Shift_Ins_p.PP537fs	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	537					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CAGATGTCCCACCCCCCCGTCC	0.574													26	367	---	---	---	---					
SSH2	85464	broad.mit.edu	37	17	27963294	27963295	+	Frame_Shift_Ins	INS	-	-	G	rs35554312		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:27963294_27963295insG	ENST00000269033.3	-	14	2023_2024	c.1872_1873insC	c.(1870-1875)cctgtcfs	p.V625fs	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Frame_Shift_Ins_p.V652fs	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	625					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCAGGGGACATGGGGGGGTCTT	0.470													10	230	---	---	---	---					
PCGF2	7703	broad.mit.edu	37	17	36896586	36896587	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:36896586_36896587insC	ENST00000580830.1	-	4	770_771	c.69_70insG	c.(67-72)ggacttfs	p.L24fs	PCGF2_ENST00000360797.2_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000581345.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000585100.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000578109.1_Intron|PCGF2_ENST00000579882.1_Frame_Shift_Ins_p.L24fs			P35227	PCGF2_HUMAN	polycomb group ring finger 2	24					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					TCGATGAAGTACCCCCCGCAGA	0.629													12	295	---	---	---	---					
CD300LG	146894	broad.mit.edu	37	17	41931337	41931338	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:41931337_41931338insC	ENST00000317310.4	+	4	685_686	c.644_645insC	c.(643-645)cccfs	p.P215fs	CD300LG_ENST00000293396.8_Frame_Shift_Ins_p.P130fs|CD300LG_ENST00000377203.4_Frame_Shift_Ins_p.P181fs|CD300LG_ENST00000586233.1_Frame_Shift_Ins_p.P130fs|CD300LG_ENST00000539718.1_Frame_Shift_Ins_p.P215fs	NM_145273.3	NP_660316.2	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g	215						apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity			central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|skin(4)	19		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GGGAGCTCCCGCCCCCCCATGC	0.629													10	99	---	---	---	---					
CA10	56934	broad.mit.edu	37	17	50008356	50008357	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:50008356_50008357insC	ENST00000451037.2	-	3	1212_1213	c.272_273insG	c.(271-273)gagfs	p.E91fs	CA10_ENST00000285273.4_Frame_Shift_Ins_p.E91fs|CA10_ENST00000340813.6_Frame_Shift_Ins_p.E97fs|CA10_ENST00000570565.1_Frame_Shift_Ins_p.E16fs|CA10_ENST00000442502.2_Frame_Shift_Ins_p.E91fs	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	91					brain development			p.G91V(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TTACCTTCCTGCCCCCCGTGTT	0.490													12	557	---	---	---	---					
ABCA6	23460	broad.mit.edu	37	17	67083603	67083604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr17:67083603_67083604insG	ENST00000284425.2	-	29	3883_3884	c.3709_3710insC	c.(3709-3711)aagfs	p.K1237fs	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1237					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATCTCTACTTTGGGGGGAAATT	0.376													10	686	---	---	---	---					
CTAGE1	64693	broad.mit.edu	37	18	19995705	19995706	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr18:19995705_19995706insG	ENST00000391403.2	-	1	2172_2173	c.2069_2070insC	c.(2068-2070)cccfs	p.P690fs		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	690	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					CTGGAGGAGGTGGGGGGAAAGG	0.500													12	491	---	---	---	---					
ZBTB7C	201501	broad.mit.edu	37	18	45566518	45566519	+	Frame_Shift_Ins	INS	-	-	C	rs113275715		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr18:45566518_45566519insC	ENST00000588982.1	-	3	1461_1462	c.960_961insG	c.(958-963)ggctctfs	p.S321fs	ZBTB7C_ENST00000590800.1_Frame_Shift_Ins_p.S321fs|ZBTB7C_ENST00000586438.1_Frame_Shift_Ins_p.S321fs|ZBTB7C_ENST00000332053.2_Frame_Shift_Ins_p.S321fs|ZBTB7C_ENST00000535628.2_Frame_Shift_Ins_p.S321fs			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	321	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GGTCCCAGAGGCCCCCCCGGCA	0.624													9	171	---	---	---	---					
ZNF532	55205	broad.mit.edu	37	18	56586491	56586492	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr18:56586491_56586492insA	ENST00000336078.4	+	4	1748_1749	c.972_973insA	c.(970-975)acaaaafs	p.TK324fs	ZNF532_ENST00000591808.1_Frame_Shift_Ins_p.TK324fs|ZNF532_ENST00000591083.1_Frame_Shift_Ins_p.TK324fs|ZNF532_ENST00000591230.1_Frame_Shift_Ins_p.TK324fs|ZNF532_ENST00000589288.1_Frame_Shift_Ins_p.TK324fs	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						TCGACGGGACCAAAAAACCATC	0.530													7	585	---	---	---	---					
C3	718	broad.mit.edu	37	19	6697480	6697481	+	Frame_Shift_Ins	INS	-	-	G	rs137956083		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:6697480_6697481insG	ENST00000245907.6	-	21	2762_2763	c.2670_2671insC	c.(2668-2673)ccagtcfs	p.V891fs		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	891					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AACGAGGACTTGGGGGGGATGG	0.574													13	522	---	---	---	---					
EMR1	2015	broad.mit.edu	37	19	6919686	6919687	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:6919686_6919687insG	ENST00000312053.4	+	13	1585_1586	c.1548_1549insG	c.(1546-1551)gtggggfs	p.VG516fs	EMR1_ENST00000450315.3_Frame_Shift_Ins_p.VG339fs|EMR1_ENST00000381407.5_Frame_Shift_Ins_p.VG375fs|EMR1_ENST00000381404.4_Frame_Shift_Ins_p.VG464fs|EMR1_ENST00000250572.8_Frame_Shift_Ins_p.VG516fs	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	516	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CTCGAGTCGTTGGGGGCATAAT	0.465													9	1333	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9064309	9064310	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:9064309_9064310insG	ENST00000397910.4	-	3	23339_23340	c.23136_23137insC	c.(23134-23139)ccctccfs	p.S7713fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7715	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAGGGGAGAGGGGGGGATAT	0.530													21	502	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10291083	10291084	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:10291083_10291084insG	ENST00000340748.4	-	4	622_623	c.387_388insC	c.(385-390)ccaaccfs	p.T130fs	DNMT1_ENST00000540357.1_Frame_Shift_Ins_p.T130fs|DNMT1_ENST00000359526.4_Frame_Shift_Ins_p.T130fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	130	Interaction with DNMT3A.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GAAAGGGGTTTGGGGGGGCTGT	0.495													13	267	---	---	---	---					
TMED1	11018	broad.mit.edu	37	19	10946787	10946788	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:10946787_10946788insG	ENST00000214869.2	-	1	178_179	c.80_81insC	c.(79-81)cccfs	p.P27fs	TMED1_ENST00000591695.1_Frame_Shift_Ins_p.P27fs	NM_006858.2	NP_006849.1	Q13445	TMED1_HUMAN	transmembrane emp24 protein transport domain containing 1	27					cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			breast(1)|central_nervous_system(2)|lung(2)|ovary(3)|prostate(1)|skin(1)	10						CCTGGATTGGCGGGGGCCCCGC	0.673													2	4	---	---	---	---					
ZNF878	729747	broad.mit.edu	37	19	12155708	12155709	+	Frame_Shift_Ins	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:12155708_12155709insT	ENST00000602107.1	-	5	647_648	c.648_649insA	c.(646-651)aacctafs	p.NL216fs	ZNF878_ENST00000547628.1_Frame_Shift_Ins_p.NL169fs|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.2_ENST00000591898.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						CATTCATAGGGTTTTTTTGCAG	0.411													22	759	---	---	---	---					
ZNF625	90589	broad.mit.edu	37	19	12256750	12256751	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:12256750_12256751insC	ENST00000355738.1	-	4	631_632	c.282_283insG	c.(280-285)ggaaccfs	p.T95fs	ZNF625_ENST00000542938.1_Frame_Shift_Ins_p.T95fs|ZNF625-ZNF20_ENST00000430024.1_Intron|ZNF625_ENST00000439556.2_Frame_Shift_Ins_p.T161fs|ZNF625_ENST00000455799.1_3'UTR			Q96I27	ZN625_HUMAN	zinc finger protein 625	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						TCATAAGGTTTCCCCCCAGTGT	0.421													7	516	---	---	---	---					
ZNF563	147837	broad.mit.edu	37	19	12430217	12430217	+	Frame_Shift_Del	DEL	A	A	-			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:12430217delA	ENST00000293725.5	-	4	827	c.622delT	c.(622-624)ggfs	p.W208fs	ZNF563_ENST00000595977.1_Intron	NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						AAACTGGGCCAAAAAAAAGCT	0.393													7	354	---	---	---	---					
TNPO2	30000	broad.mit.edu	37	19	12812575	12812576	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:12812575_12812576insC	ENST00000425528.1	-	23	2858_2859	c.2501_2502insG	c.(2500-2502)ggtfs	p.G834fs	TNPO2_ENST00000588216.1_Frame_Shift_Ins_p.G824fs|TNPO2_ENST00000450764.2_Frame_Shift_Ins_p.G824fs|TNPO2_ENST00000441499.1_Frame_Shift_Ins_p.G824fs|TNPO2_ENST00000356861.5_Frame_Shift_Ins_p.G824fs|TNPO2_ENST00000592287.1_Frame_Shift_Ins_p.G834fs			O14787	TNPO2_HUMAN	transportin 2	834					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCTGCACAACGCCCCCCGGGTT	0.639													8	95	---	---	---	---					
EMR3	84658	broad.mit.edu	37	19	14774330	14774331	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:14774330_14774331insG	ENST00000253673.5	-	3	198_199	c.98_99insC	c.(97-99)caafs	p.Q33fs	EMR3_ENST00000443157.2_Frame_Shift_Ins_p.Q33fs|EMR3_ENST00000599900.1_5'UTR|EMR3_ENST00000344373.4_Frame_Shift_Ins_p.Q33fs	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	33	EGF-like 1.				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						AGGAAGCATTTGGGGGGCACTT	0.485													7	268	---	---	---	---					
AP1M1	8907	broad.mit.edu	37	19	16314383	16314384	+	Frame_Shift_Ins	INS	-	-	G	rs146546344	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:16314383_16314384insG	ENST00000291439.3	+	2	605_606	c.156_157insG	c.(154-159)caggggfs	p.QG52fs	AP1M1_ENST00000444449.2_Frame_Shift_Ins_p.QG52fs|AP1M1_ENST00000429941.2_Frame_Shift_Ins_p.QG52fs|AP1M1_ENST00000541844.1_Intron|AP1M1_ENST00000590756.1_Intron	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	52					cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						TCCTGGCCCACGGGGGGGTCCG	0.594													7	180	---	---	---	---					
NWD1	284434	broad.mit.edu	37	19	16860826	16860827	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:16860826_16860827insC	ENST00000524140.2	+	6	1791_1792	c.1373_1374insC	c.(1372-1374)tccfs	p.S458fs	NWD1_ENST00000552788.1_Frame_Shift_Ins_p.S458fs|NWD1_ENST00000549814.1_Frame_Shift_Ins_p.S458fs|NWD1_ENST00000523826.1_Frame_Shift_Ins_p.S252fs|NWD1_ENST00000379808.3_Frame_Shift_Ins_p.S458fs|NWD1_ENST00000339803.6_Frame_Shift_Ins_p.S323fs	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	458	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CCTCTCAACTGCCCCCCGAGGG	0.629													7	228	---	---	---	---					
TSHZ3	57616	broad.mit.edu	37	19	31769061	31769062	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:31769061_31769062insC	ENST00000240587.4	-	2	1964_1965	c.1637_1638insG	c.(1636-1638)gtafs	p.V546fs		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	546					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TGCTGGGATAGCCCCCCCAGCT	0.559													35	328	---	---	---	---					
CD22	933	broad.mit.edu	37	19	35832248	35832249	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:35832248_35832249insC	ENST00000085219.5	+	8	1576_1577	c.1510_1511insC	c.(1510-1512)cccfs	p.P504fs	CD22_ENST00000536635.2_Frame_Shift_Ins_p.P416fs|CD22_ENST00000594250.1_Frame_Shift_Ins_p.P327fs|CD22_ENST00000544992.2_Frame_Shift_Ins_p.P504fs|CD22_ENST00000341773.6_Frame_Shift_Ins_p.P327fs|CD22_ENST00000419549.2_Frame_Shift_Ins_p.P332fs|CD22_ENST00000270311.6_Frame_Shift_Ins_p.P384fs	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	504					cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CCCTCCAGATGCCCCCCGAGAC	0.619													7	187	---	---	---	---					
FBL	2091	broad.mit.edu	37	19	40325192	40325193	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:40325192_40325193insG	ENST00000221801.3	-	9	1064_1065	c.951_952insC	c.(949-954)ccaggtfs	p.G318fs	FBL_ENST00000593503.1_5'UTR	NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	318					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		TTCTTCACCTTGGGGGGTGGCC	0.505													13	430	---	---	---	---					
PSMC4	5704	broad.mit.edu	37	19	40480653	40480654	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:40480653_40480654insC	ENST00000157812.2	+	6	789_790	c.591_592insC	c.(589-594)gaccccfs	p.DP197fs	PSMC4_ENST00000455878.2_Frame_Shift_Ins_p.DP166fs	NM_006503.3|NM_153001.2	NP_006494.1|NP_694546.1	P43686	PRS6B_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 4	197					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCGGCATCGATCCCCCCCGAGG	0.614													7	138	---	---	---	---					
CEACAM5	1048	broad.mit.edu	37	19	42224865	42224866	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:42224865_42224866insC	ENST00000221992.6	+	8	1909_1910	c.1795_1796insC	c.(1795-1797)cccfs	p.P599fs	CEACAM5_ENST00000398599.4_Frame_Shift_Ins_p.P598fs|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Frame_Shift_Ins_p.P599fs	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	599	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCCCATCATTTCCCCCCCAGAC	0.545													18	438	---	---	---	---					
POU2F2	5452	broad.mit.edu	37	19	42621520	42621521	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:42621520_42621521insG	ENST00000560398.1	-	5	257_258	c.250_251insC	c.(250-252)gatfs	p.D84fs	POU2F2_ENST00000533720.1_Splice_Site|POU2F2_ENST00000389341.5_Splice_Site|POU2F2_ENST00000342301.4_Splice_Site|POU2F2_ENST00000529952.1_Splice_Site|POU2F2_ENST00000529067.1_Splice_Site|POU2F2_ENST00000526816.2_Splice_Site|POU2F2_ENST00000560558.1_Intron|POU2F2_ENST00000524801.2_Splice_Site			P09086	PO2F2_HUMAN	POU class 2 homeobox 2	62					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(69;0.059)				AGCCTTGATCTGGGGGGGAGAG	0.634													21	419	---	---	---	---					
MEGF8	1954	broad.mit.edu	37	19	42866542	42866543	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:42866542_42866543insC	ENST00000334370.4	+	33	6285_6286	c.5650_5651insC	c.(5650-5652)cccfs	p.P1884fs	MEGF8_ENST00000251268.6_Frame_Shift_Ins_p.P1951fs	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1951	PSI 4.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CCAGGCGTCCACCCCCCGCTGT	0.614													7	292	---	---	---	---					
MARK4	57787	broad.mit.edu	37	19	45805663	45805664	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:45805663_45805664insC	ENST00000300843.4	+	18	2331_2332	c.2034_2035insC	c.(2032-2037)ccccccfs	p.PP678fs	MARK4_ENST00000262891.4_Frame_Shift_Ins_p.P652fs	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	0					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AACGGAAACCGCCCCCCGGCTG	0.639													7	543	---	---	---	---					
CARD8	22900	broad.mit.edu	37	19	48737669	48737670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:48737669_48737670insC	ENST00000391898.3	-	3	382_383	c.340_341insG	c.(340-342)catfs	p.H114fs	CARD8_ENST00000357778.5_5'UTR|ZNF114_ENST00000597695.1_Intron|CARD8_ENST00000359009.4_Frame_Shift_Ins_p.I23fs|CARD8_ENST00000521613.1_Frame_Shift_Ins_p.H64fs|CARD8_ENST00000447740.2_Frame_Shift_Ins_p.H64fs|CARD8_ENST00000520753.1_Frame_Shift_Ins_p.H114fs|CARD8_ENST00000519940.1_Frame_Shift_Ins_p.H114fs|CARD8_ENST00000520153.1_Frame_Shift_Ins_p.H64fs|CARD8_ENST00000520015.1_Frame_Shift_Ins_p.H114fs	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	0					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		CCTGGGAATGTCCCCCCCAGAT	0.436													16	313	---	---	---	---					
LMTK3	114783	broad.mit.edu	37	19	48994757	48994758	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:48994757_48994758insG	ENST00000600059.1	-	13	4358_4359	c.4131_4132insC	c.(4129-4134)ccagggfs	p.G1378fs	LMTK3_ENST00000270238.3_Frame_Shift_Ins_p.G1407fs					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GTGTCCCCCTCGGGGGGGGCCT	0.658													7	21	---	---	---	---					
FAM83E	54854	broad.mit.edu	37	19	49107037	49107038	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:49107037_49107038insG	ENST00000263266.3	-	4	1078_1079	c.889_890insC	c.(889-891)gaafs	p.E297fs		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	297										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CGAGGGTTTCTGGGGGGGCGCA	0.723													8	55	---	---	---	---					
PLEKHA4	57664	broad.mit.edu	37	19	49364680	49364681	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:49364680_49364681insG	ENST00000263265.6	-	5	898_899	c.343_344insC	c.(343-345)aggfs	p.R115fs	PLEKHA4_ENST00000355496.5_Frame_Shift_Ins_p.R115fs	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	115	PH.					cytoplasm|membrane	1-phosphatidylinositol binding	p.R115R(1)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GCGCCGCCCTCGGGGGGCTCCC	0.604													8	363	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243063	50243064	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:50243063_50243064insG	ENST00000246801.3	-	11	1830_1831	c.1748_1749insC	c.(1747-1749)caafs	p.Q583fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.Q383fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	583							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCCCCTGTTTTGGGGGGGTTCC	0.545													29	513	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243087	50243088	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:50243087_50243088insC	ENST00000246801.3	-	11	1806_1807	c.1724_1725insG	c.(1723-1725)gggfs	p.G575fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.G375fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	575							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CACTGCTGCCTCCCCCCATTGT	0.554													7	596	---	---	---	---					
SHANK1	50944	broad.mit.edu	37	19	51192459	51192460	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:51192459_51192460insC	ENST00000293441.1	-	15	2059_2060	c.2041_2042insG	c.(2041-2043)caafs	p.Q681fs	SHANK1_ENST00000359082.3_Frame_Shift_Ins_p.Q672fs|SHANK1_ENST00000391814.1_Frame_Shift_Ins_p.Q681fs|SHANK1_ENST00000391813.1_Frame_Shift_Ins_p.Q68fs	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	681	PDZ.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding	p.A681S(1)		breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CTCACCCTTGGCCCCCCGGAGC	0.609													10	408	---	---	---	---					
GPR32	2854	broad.mit.edu	37	19	51274914	51274915	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:51274914_51274915insC	ENST00000270590.4	+	1	1194_1195	c.1057_1058insC	c.(1057-1059)cccfs	p.P353fs		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	353						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CCGTGGCAACGCCCCCCGGGAA	0.525													7	253	---	---	---	---					
KLK1	3816	broad.mit.edu	37	19	51326962	51326963	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:51326962_51326963insC	ENST00000301420.2	-	1	77_78	c.42_43insG	c.(40-45)ggctggfs	p.W15fs	KLK1_ENST00000448701.2_5'UTR	NM_002257.2	NP_002248.1	P06870	KLK1_HUMAN	kallikrein 1	15					proteolysis	nucleus	serine-type endopeptidase activity			breast(1)|large_intestine(4)|lung(7)|urinary_tract(1)	13		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCTCACCAGTCCCCCCCAGGG	0.653													22	368	---	---	---	---					
ZNF175	7728	broad.mit.edu	37	19	52090436	52090437	+	Frame_Shift_Ins	INS	-	-	G	rs138396190		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:52090436_52090437insG	ENST00000262259.2	+	5	1210_1211	c.852_853insG	c.(850-855)tgggggfs	p.WG284fs	ZNF175_ENST00000436511.2_Intron	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	284					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		GTTCTGAATGTGGGGGGAGCTT	0.441													11	717	---	---	---	---					
ZNF649	65251	broad.mit.edu	37	19	52394013	52394014	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:52394013_52394014insC	ENST00000354957.3	-	5	1659_1660	c.1375_1376insG	c.(1375-1377)ttcfs	p.F459fs	ZNF649_ENST00000600738.1_Frame_Shift_Ins_p.F431fs|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTCACTGAATCCCCCCGTTTC	0.450													7	1065	---	---	---	---					
CNOT3	4849	broad.mit.edu	37	19	54649666	54649667	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr19:54649666_54649667insC	ENST00000406403.1	+	8	2327_2328	c.724_725insC	c.(724-726)cccfs	p.P242fs	CNOT3_ENST00000358389.3_Frame_Shift_Ins_p.P61fs|CNOT3_ENST00000221232.5_Frame_Shift_Ins_p.P242fs			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	242					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGTCGCCACCTCCCCTCCCAGC	0.644													12	169	---	---	---	---					
FASTKD5	60493	broad.mit.edu	37	20	3128000	3128001	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:3128000_3128001insC	ENST00000380266.3	-	2	2037_2038	c.1716_1717insG	c.(1714-1719)ggcccafs	p.GP572fs	UBOX5_ENST00000348031.2_Intron|UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	572					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						ACGTACTGGGGCCCCCCCAGCA	0.436													11	192	---	---	---	---					
CST4	1472	broad.mit.edu	37	20	23667825	23667826	+	Frame_Shift_Ins	INS	-	-	C	rs140501583		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:23667825_23667826insC	ENST00000217423.3	-	2	311_312	c.241_242insG	c.(241-243)gaafs	p.E81fs		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	81						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					GAAGTAATTCACCCCCCCAAAG	0.554													24	405	---	---	---	---					
TM9SF4	9777	broad.mit.edu	37	20	30737490	30737491	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:30737490_30737491insC	ENST00000217315.5	+	10	1297_1298	c.957_958insC	c.(955-960)agccccfs	p.SP319fs	TM9SF4_ENST00000398022.2_Frame_Shift_Ins_p.SP336fs			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	336						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ACGTCTTCAGGCCCCCCCAGTA	0.604													10	140	---	---	---	---					
RALGAPB	57148	broad.mit.edu	37	20	37146232	37146233	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:37146232_37146233insC	ENST00000262879.6	+	8	1419_1420	c.1135_1136insC	c.(1135-1137)cccfs	p.P379fs	RALGAPB_ENST00000397038.1_Frame_Shift_Ins_p.P157fs|RALGAPB_ENST00000397040.1_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000397042.3_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000537204.1_Frame_Shift_Ins_p.P379fs			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	379					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity	p.H382fs*2(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGTCAGTACCACCCCCCCACAT	0.446													11	227	---	---	---	---					
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:43881730_43881731insG	ENST00000338380.2	-	3	326_327	c.306_307insC	c.(304-309)ccatttfs	p.F103fs		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535													14	375	---	---	---	---					
RBPJL	11317	broad.mit.edu	37	20	43940237	43940238	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:43940237_43940238insC	ENST00000343694.3	+	4	338_339	c.266_267insC	c.(265-267)tccfs	p.S89fs	RBPJL_ENST00000372741.3_Frame_Shift_Ins_p.S89fs|RBPJL_ENST00000372743.1_Frame_Shift_Ins_p.S89fs	NM_014276.2	NP_055091.2	Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	89					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				AGGTTCTTCTGCCCCCCGCCCT	0.604											OREG0025979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	216	---	---	---	---					
SLC13A3	64849	broad.mit.edu	37	20	45194969	45194970	+	Frame_Shift_Ins	INS	-	-	G	rs149123701	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr20:45194969_45194970insG	ENST00000279027.4	-	11	1410_1411	c.1392_1393insC	c.(1390-1395)ccccctfs	p.PP464fs	SLC13A3_ENST00000435032.1_Frame_Shift_Ins_p.PP49fs|SLC13A3_ENST00000413164.2_Frame_Shift_Ins_p.PP414fs|SLC13A3_ENST00000495082.1_Frame_Shift_Ins_p.PP417fs|SLC13A3_ENST00000396360.1_Frame_Shift_Ins_p.PP382fs|SLC13A3_ENST00000472148.1_Frame_Shift_Ins_p.PP382fs|SLC13A3_ENST00000290317.5_Frame_Shift_Ins_p.PP417fs	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	464						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity	p.P464P(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	ACAGCCAGGGCGGGGGGCACAT	0.604													7	475	---	---	---	---					
DSCAM	1826	broad.mit.edu	37	21	41514614	41514615	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr21:41514614_41514615insG	ENST00000400454.1	-	18	3753_3754	c.3276_3277insC	c.(3274-3279)ccaaaafs	p.PK1092fs		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1092	Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.E1093K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACATTTTCGGGGGGGTAAC	0.406													18	496	---	---	---	---					
TSPEAR	54084	broad.mit.edu	37	21	45987772	45987773	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr21:45987772_45987773insG	ENST00000323084.4	-	2	264_265	c.199_200insC	c.(199-201)cacfs	p.H67fs	TSPEAR_ENST00000397916.1_5'UTR	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	67					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GCTCATGGTGCGGGGGGCGGCT	0.564													8	182	---	---	---	---					
MCM3AP	8888	broad.mit.edu	37	21	47663396	47663397	+	Frame_Shift_Ins	INS	-	-	G	rs34589822	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr21:47663396_47663397insG	ENST00000397708.1	-	25	5532_5533	c.5278_5279insC	c.(5278-5280)gctfs	p.A1760fs	MCM3AP-AS1_ENST00000414659.1_RNA|MCM3AP-AS1_ENST00000591223.1_RNA|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP_ENST00000467026.1_5'UTR|MCM3AP-AS1_ENST00000588753.1_RNA|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP_ENST00000291688.1_Frame_Shift_Ins_p.A1760fs			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1760					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					AACAGGAAGCCGGGGGGGCGTC	0.525													15	331	---	---	---	---					
CECR1	51816	broad.mit.edu	37	22	17662759	17662760	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:17662759_17662760insC	ENST00000399839.1	-	9	1662_1663	c.1392_1393insG	c.(1390-1395)ggtgaafs	p.E465fs	CECR1_ENST00000399837.2_Frame_Shift_Ins_p.E465fs|CECR1_ENST00000449907.2_Frame_Shift_Ins_p.E423fs|CECR1_ENST00000330232.4_Frame_Shift_Ins_p.E224fs|CECR1_ENST00000262607.3_Frame_Shift_Ins_p.E465fs			Q9NZK5	CECR1_HUMAN	cat eye syndrome chromosome region, candidate 1	465					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				TCAGCCTTCATCCCCCCAATGC	0.564													7	423	---	---	---	---					
P2RX6P	440799	broad.mit.edu	37	22	21399220	21399221	+	RNA	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:21399220_21399221insC	ENST00000439119.1	-	0	51					NR_002829.1																						TCTGCAGGGCGCCCCCCCACCA	0.599													17	369	---	---	---	---					
ZNF280A	129025	broad.mit.edu	37	22	22869526	22869527	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:22869526_22869527insG	ENST00000302097.3	-	2	680_681	c.428_429insC	c.(427-429)cggfs	p.R143fs		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ACTGAGTCCCTGGGGGGAGCGA	0.455													9	368	---	---	---	---					
GNAZ	2781	broad.mit.edu	37	22	23438487	23438488	+	Frame_Shift_Ins	INS	-	-	G			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:23438487_23438488insG	ENST00000248996.4	+	2	1271_1272	c.605_606insG	c.(604-606)gggfs	p.G202fs	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	202						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		ATGGTGGACGTGGGGGGGCAGA	0.574													8	84	---	---	---	---					
SEZ6L	23544	broad.mit.edu	37	22	26688484	26688485	+	Frame_Shift_Ins	INS	-	-	C	rs145637105	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:26688484_26688485insC	ENST00000529632.2	+	2	403_404	c.207_208insC	c.(205-210)gcccccfs	p.AP69fs	SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000343706.4_Frame_Shift_Ins_p.AP69fs|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000360929.3_Frame_Shift_Ins_p.AP69fs|SEZ6L_ENST00000404234.3_Frame_Shift_Ins_p.AP69fs|SEZ6L_ENST00000248933.6_Frame_Shift_Ins_p.AP69fs	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	69						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						TGGTAACAGCGCCCCCCAGTTC	0.634													7	191	---	---	---	---					
GTPBP1	9567	broad.mit.edu	37	22	39122087	39122088	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:39122087_39122088insC	ENST00000216044.5	+	7	1383_1384	c.1150_1151insC	c.(1150-1152)cccfs	p.P384fs	GTPBP1_ENST00000460605.1_3'UTR	NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	384					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					CAACCTCCTCTCCCCCCGCACC	0.569													10	408	---	---	---	---					
TNRC6B	23112	broad.mit.edu	37	22	40681766	40681767	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:40681766_40681767insC	ENST00000454349.2	+	12	3911_3912	c.3700_3701insC	c.(3700-3702)cccfs	p.P1234fs	TNRC6B_ENST00000301923.9_Frame_Shift_Ins_p.P430fs|TNRC6B_ENST00000497559.1_3'UTR|TNRC6B_ENST00000402203.1_Frame_Shift_Ins_p.P430fs|TNRC6B_ENST00000335727.8_Frame_Shift_Ins_p.P1124fs	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1234					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						CCAGTTTATTTCCCCCCAGGTA	0.450													11	775	---	---	---	---					
EP300	2033	broad.mit.edu	37	22	41574678	41574679	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:41574678_41574679insC	ENST00000263253.7	+	31	8182_8183	c.6963_6964insC	c.(6961-6966)caccccfs	p.HP2321fs	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	2321					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CACAGTCCCAGCCCCCCCACTC	0.609			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				14	220	---	---	---	---					
SREBF2	6721	broad.mit.edu	37	22	42271636	42271637	+	Frame_Shift_Ins	INS	-	-	C	rs79727196		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:42271636_42271637insC	ENST00000361204.4	+	7	1460_1461	c.1294_1295insC	c.(1294-1296)cccfs	p.P432fs		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	432	Interaction with LMNA (By similarity).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						CCTTCTGATGTCCCCCCCAGCC	0.520													15	260	---	---	---	---					
CYP2D6	1565	broad.mit.edu	37	22	42524213	42524214	+	Frame_Shift_Ins	INS	-	-	G	rs72549352		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:42524213_42524214insG	ENST00000360608.5	-	5	919_920	c.805_806insC	c.(805-807)agafs	p.R269fs	NDUFA6-AS1_ENST00000439129.1_RNA|CYP2D6_ENST00000359033.4_Frame_Shift_Ins_p.R218fs|NDUFA6-AS1_ENST00000416037.1_RNA|CYP2D6_ENST00000389970.3_Frame_Shift_Ins_p.R269fs	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	269							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AGTCAGGTCTCGGGGGGGCTGG	0.629													7	78	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42610947	42610948	+	Frame_Shift_Ins	INS	-	-	G	rs138734341		TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:42610947_42610948insG	ENST00000359486.3	-	1	500_501	c.364_365insC	c.(364-366)gggfs	p.G122fs	TCF20_ENST00000335626.4_Frame_Shift_Ins_p.G122fs	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	122				Q -> R (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						GCTGCTCCCCTGGGGGGGTCCA	0.564													30	889	---	---	---	---					
TBC1D22A	25771	broad.mit.edu	37	22	47188443	47188444	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr22:47188443_47188444insC	ENST00000337137.4	+	2	255_256	c.89_90insC	c.(88-90)cccfs	p.P30fs	TBC1D22A_ENST00000406733.1_5'UTR|TBC1D22A_ENST00000407381.3_Frame_Shift_Ins_p.P30fs|TBC1D22A_ENST00000472791.1_3'UTR|TBC1D22A_ENST00000380995.1_5'UTR|TBC1D22A_ENST00000355704.3_Intron	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	30						intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GGTGCCCAGCACCCCCCCTTTG	0.569													14	281	---	---	---	---					
SSX9	280660	broad.mit.edu	37	X	48159107	48159108	+	Frame_Shift_Ins	INS	-	-	G	rs41305745	by1000genomes	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chrX:48159107_48159108insG	ENST00000376909.1	-	6	487_488	c.425_426insC	c.(424-426)cggfs	p.R142fs	SSX9_ENST00000407081.2_Frame_Shift_Ins_p.R142fs																breast(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|stomach(1)	8						TTGGTTTTCCCGGGGGGCACAG	0.490													7	567	---	---	---	---					
SSX3	10214	broad.mit.edu	37	X	48209462	48209463	+	Frame_Shift_Ins	INS	-	-	G	rs6651589	byFrequency	TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chrX:48209462_48209463insG	ENST00000298396.2	-	6	477_478	c.425_426insC	c.(424-426)cggfs	p.R142fs	SSX3_ENST00000376893.3_Frame_Shift_Ins_p.R142fs|SSX3_ENST00000376895.1_Frame_Shift_Ins_p.R54fs	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding	p.P142Q(2)		endometrium(3)|large_intestine(1)|lung(9)	13						TTGGTTTTCCCGGGGGGCACAG	0.495													10	466	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73043501	73043502	+	RNA	INS	-	-	T			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chrX:73043501_73043502insT	ENST00000604411.1	+	0	31462_31463				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						ACAACACCTTGTTTTTTGCAAA	0.391													7	433	---	---	---	---					
ZNF449	203523	broad.mit.edu	37	X	134494267	134494268	+	Frame_Shift_Ins	INS	-	-	C			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chrX:134494267_134494268insC	ENST00000339249.4	+	5	963_964	c.823_824insC	c.(823-825)cccfs	p.P275fs		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	275					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TCAATGGGAAACCCCCCCAGAG	0.436													7	161	---	---	---	---					
MCF2	4168	broad.mit.edu	37	X	138697051	138697052	+	Frame_Shift_Ins	INS	-	-	A			TCGA-AK-3465-01A-01W-0886-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12b8a067-6ffb-4d17-8f3b-efaeecd1cf57	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chrX:138697051_138697052insA	ENST00000520602.1	-	13	1816_1817	c.1531_1532insT	c.(1531-1533)atcfs	p.I511fs	MCF2_ENST00000370573.4_Frame_Shift_Ins_p.I451fs|MCF2_ENST00000338585.6_Frame_Shift_Ins_p.I451fs|MCF2_ENST00000370576.4_Frame_Shift_Ins_p.I451fs|MCF2_ENST00000370578.4_Frame_Shift_Ins_p.I596fs|MCF2_ENST00000519895.1_Frame_Shift_Ins_p.I511fs|MCF2_ENST00000483690.1_5'UTR|MCF2_ENST00000536274.1_Frame_Shift_Ins_p.I412fs|MCF2_ENST00000414978.1_Frame_Shift_Ins_p.I511fs			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	451	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TTGTTTAGATGAAAAAAATGGT	0.371													7	524	---	---	---	---					
RP11-231C18.1	0	broad.mit.edu	37	4	55201143	55201144	+	RNA	INS	-	-	TTT			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr4:55201143_55201144insTTT	ENST00000511634.1	+	0	43																											ctccttccctcccttccttcct	0.490													3	5	---	---	---	---					
FNIP1	96459	broad.mit.edu	37	5	131013435	131013435	+	Frame_Shift_Del	DEL	C	C	-			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr5:131013435delC	ENST00000307968.7	-	12	1395	c.1396delG	c.(1396-1398)cafs	p.A466fs	FNIP1_ENST00000510461.1_Frame_Shift_Del_p.A494fs|FNIP1_ENST00000511848.1_Frame_Shift_Del_p.A494fs|FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000307954.8_Frame_Shift_Del_p.A449fs	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TGAGTCTTTGCCAACATGTCC	0.383													105	190	---	---	---	---					
LRRC14	9684	broad.mit.edu	37	8	145746499	145746502	+	Frame_Shift_Del	DEL	TGAG	TGAG	-			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr8:145746499_145746502delTGAG	ENST00000292524.1	+	4	1265_1268	c.1119_1122delTGAG	c.(1117-1122)acfs	p.TE373fs	LRRC14_ENST00000529022.1_Frame_Shift_Del_p.TE373fs	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	373										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGGAGCTGACTGAGTGTCAGCTCG	0.593													51	105	---	---	---	---					
CCDC176	80127	broad.mit.edu	37	14	74514756	74514760	+	Frame_Shift_Del	DEL	TACTT	TACTT	-			TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr14:74514756_74514760delTACTT	ENST00000394009.3	+	7	894_898	c.771_775delTACTT	c.(769-777)catafs	p.HTL257fs	CCDC176_ENST00000553773.1_5'UTR|AC005484.5_ENST00000492026.1_RNA|CCDC176_ENST00000489323.1_3'UTR	NM_025057.2	NP_079333.2			coiled-coil domain containing 176																		AAGAGAGTCATACTTTACTTTTACA	0.341													37	70	---	---	---	---					
RP11-519G16.3	0	broad.mit.edu	37	15	45756158	45756158	+	RNA	DEL	T	T	-	rs143709087		TCGA-AK-3465-01A-01D-0966-08	TCGA-AK-3465-10A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c54f90a1-01c2-4cde-959e-bf3219673495	2ee3db04-cb72-4a8a-a66a-bd5784f1e01f	g.chr15:45756158delT	ENST00000560077.1	+	0	41				RP11-519G16.3_ENST00000558536.1_RNA|RP11-519G16.3_ENST00000560647.1_RNA																							accaccaccatcaccatcacc	0.567													2	4	---	---	---	---