Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KCNK3	3777	broad.mit.edu	37	2	26950601	26950601	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr2:26950601G>A	ENST00000302909.3	+	2	475	c.350G>A	c.(349-351)gGc>gAc	p.G117D		NM_002246.2	NP_002237.1	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	117					synaptic transmission	integral to plasma membrane				endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGCTGCTGGGCATCCCGCTC	0.632000													4	161					0	0	0.150653	0	0
WDR52	55779	broad.mit.edu	37	3	113115480	113115480	+	Missense_Mutation	SNP	G	G	A	rs145391746		TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr3:113115480G>A	ENST00000393845.2	-	14	1730	c.1664C>T	c.(1663-1665)gCg>gTg	p.A555V	WDR52_ENST00000475568.1_5'UTR|WDR52_ENST00000295868.2_Missense_Mutation_p.A555V	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	555										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						CTTCCGTCCCGCAAAAATCGT	0.398000													4	163					0	0	0.150653	0	0
FAM66D	100132923	broad.mit.edu	37	8	11986719	11986719	+	RNA	SNP	G	G	C			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr8:11986719G>C	ENST00000434078.2	+	0	608					NR_027425.1																						TGGATTTCAGGAAAAGCTGCA	0.522000													4	164					0	0	0.038147	0	0
OR13C8	138802	broad.mit.edu	37	9	107331658	107331658	+	Silent	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr9:107331658C>T	ENST00000335040.1	+	1	210	c.210C>T	c.(208-210)gaC>gaT	p.D70D		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						CCTTCCTCGACGTTTGCTACA	0.423000													7	523					0	0	0.029380	0	0
MYBPHL	343263	broad.mit.edu	37	1	109838960	109838960	+	Nonsense_Mutation	SNP	G	G	A	rs139849511	byFrequency	TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr1:109838960G>A	ENST00000357155.1	-	6	812	c.763C>T	c.(763-765)Cga>Tga	p.R255*	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	255								p.R255*(1)		central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		GAGAAGTCTCGTTGGGCAAAC	0.552000													4	102					0	0	0.150653	0	0
MUC17	140453	broad.mit.edu	37	7	100682390	100682390	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr7:100682390C>A	ENST00000306151.4	+	3	7757	c.7693C>A	c.(7693-7695)Cct>Act	p.P2565T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2565	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCTACCTCAAC	0.488000													149	306					5.47995e-64	6.99568e-64	0.139131	1	0
TADA2B	93624	broad.mit.edu	37	4	7056535	7056535	+	Silent	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr4:7056535C>T	ENST00000310074.7	+	2	1206	c.1017C>T	c.(1015-1017)ttC>ttT	p.F339F	TADA2B_ENST00000515646.1_Silent_p.F247F|TADA2B_ENST00000512388.1_Silent_p.F264F	NM_152293.2	NP_689506.2	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2B	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding			breast(3)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	18						ACAGCGAGTTCGCCGCCATTG	0.562000													5	90					0	0	0.014758	0	0
IGDCC3	9543	broad.mit.edu	37	15	65667723	65667723	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr15:65667723C>A	ENST00000327987.4	-	2	372	c.121G>T	c.(121-123)Gaa>Taa	p.E41*		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	41	Ig-like C2-type 1.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						AATGCCAGTTCAGCAGAGTGG	0.552000													3	29					0.115264	0.117218	0.115264	1	0
ABCC6	368	broad.mit.edu	37	16	16295884	16295884	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr16:16295884C>T	ENST00000205557.7	-	9	1179	c.1150G>A	c.(1150-1152)Gcc>Acc	p.A384T	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	384	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCAGTGATGGCCGACCGCAAC	0.572000													4	161					0	0	0.014758	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													4	0					0	0	0.150653	0	0
MYOF	26509	broad.mit.edu	37	10	95216640	95216640	+	Splice_Site	SNP	T	T	C			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr10:95216640T>C	ENST00000371501.4	-	2	265	c.144_splice	c.e2+1	p.E48_splice	MYOF_ENST00000371489.1_Splice_Site_p.E48_splice|MYOF_ENST00000371502.4_Splice_Site_p.E48_splice|MYOF_ENST00000358334.5_Splice_Site_p.E48_splice|MYOF_ENST00000359263.4_Splice_Site_p.E48_splice|MYOF_ENST00000371488.3_Splice_Site_p.E48_splice			Q9NZM1	MYOF_HUMAN	myoferlin	48	C2 1.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGAAGTCACCTCATTCCAGAC	0.333000													3	128					0	0	0.150653	0	0
MTRR	4552	broad.mit.edu	37	5	7895897	7895897	+	Silent	SNP	C	C	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr5:7895897C>A	ENST00000264668.2	+	12	1719	c.1689C>A	c.(1687-1689)ccC>ccA	p.P563P	MTRR_ENST00000440940.2_Silent_p.P536P	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	563					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CAGATGACCCCTCAATCCCCA	0.408000													5	373					8.12818e-05	9.56257e-05	0.029380	1	0
TP53	7157	broad.mit.edu	37	17	7578272	7578272	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr17:7578272G>A	ENST00000420246.2	-	6	709	c.577C>T	c.(577-579)Cat>Tat	p.H193Y	TP53_ENST00000359597.4_Missense_Mutation_p.H193Y|TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Missense_Mutation_p.H193Y|TP53_ENST00000413465.2_Missense_Mutation_p.H193Y|TP53_ENST00000455263.2_Missense_Mutation_p.H193Y|TP53_ENST00000445888.2_Missense_Mutation_p.H193Y	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	193	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		H -> D (in sporadic cancers; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193Y(29)|p.H193D(13)|p.0?(8)|p.?(6)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.H61D(2)|p.H100D(2)|p.P191fs*15(1)|p.H61Y(1)|p.P191fs*6(1)|p.H100Y(1)|p.P98_E105>Q(1)|p.H193_I195delHLI(1)|p.P59_E66>Q(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGATAAGATGCTGAGGAGGG	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			37	30					0	0	0.074837	0	0
SGCG	6445	broad.mit.edu	37	13	23869612	23869612	+	Silent	SNP	G	G	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr13:23869612G>T	ENST00000218867.3	+	6	688	c.564G>T	c.(562-564)ccG>ccT	p.P188P	SGCG_ENST00000545013.1_Silent_p.P188P|SGCG_ENST00000537476.1_Silent_p.P188P	NM_000231.2	NP_000222.1	Q13326	SGCG_HUMAN	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	188					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		GAGCCGACCCGTTTCAAGACC	0.408000													83	183					9.10118e-52	1.13765e-51	0.139131	1	0
GPR137	56834	broad.mit.edu	37	11	64056826	64056826	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr11:64056826C>T	ENST00000411458.1	+	9	1445	c.1417C>T	c.(1417-1419)Ccg>Tcg	p.P473S	GPR137_ENST00000313074.3_Missense_Mutation_p.P415S|GPR137_ENST00000438980.2_3'UTR|GPR137_ENST00000377702.4_3'UTR|GPR137_ENST00000539851.1_3'UTR	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	415						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						TGAGCTTGTGCCGTCCCCCTA	0.647000													4	148					0	0	0.150653	0	0
UQCR10	29796	broad.mit.edu	37	22	30163417	30163417	+	Silent	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr22:30163417G>A	ENST00000330029.6	+	1	60	c.30G>A	c.(28-30)ttG>ttA	p.L10L	UQCR10_ENST00000401406.3_Silent_p.L10L	NM_001003684.1|NM_013387.3	NP_001003684.1|NP_037519.2	Q9UDW1	QCR9_HUMAN	ubiquinol-cytochrome c reductase, complex III subunit X	10					mitochondrial electron transport, ubiquinol to cytochrome c	mitochondrial inner membrane|respiratory chain	ubiquinol-cytochrome-c reductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)	5						CTTCGAAATTGTACTCCCTGC	0.622000													25	47					0	0	0.108266	0	0
RAB11FIP2	22841	broad.mit.edu	37	10	119798885	119798885	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr10:119798885C>G	ENST00000355624.3	-	3	1302	c.863G>C	c.(862-864)aGc>aCc	p.S288T	RP11-354M20.3_ENST00000451610.2_RNA|RAB11FIP2_ENST00000369199.3_Missense_Mutation_p.S288T	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	288					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		ATCCACAATGCTGTCAGGTTG	0.368000													6	152					0	0	0.021553	0	0
SARDH	1757	broad.mit.edu	37	9	136573487	136573487	+	Silent	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr9:136573487G>A	ENST00000371872.4	-	11	1649	c.1392C>T	c.(1390-1392)taC>taT	p.Y464Y	SARDH_ENST00000439388.1_Silent_p.Y464Y|SARDH_ENST00000422262.2_Silent_p.Y296Y	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	464					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		AGTTCTTGGCGTAGGACTCAT	0.652000													14	115					0	0	0.119110	0	0
ZNF626	199777	broad.mit.edu	37	19	20807796	20807796	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr19:20807796C>T	ENST00000601440.1	-	4	1033	c.887G>A	c.(886-888)cGg>cAg	p.R296Q	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						GGTTGAGGACCGGTTGAAGGC	0.388000													5	281					0	0	0.021553	0	0
HENMT1	113802	broad.mit.edu	37	1	109191481	109191481	+	Silent	SNP	G	G	T	rs140991391	by1000genomes	TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr1:109191481G>T	ENST00000370032.5	-	8	1309	c.889C>A	c.(889-891)Cgg>Agg	p.R297R	HENMT1_ENST00000402983.1_Silent_p.R297R|HENMT1_ENST00000370031.1_Silent_p.R328R	NM_144584.2	NP_653185.2	Q5T8I9	HENMT_HUMAN	HEN1 methyltransferase homolog 1 (Arabidopsis)	297					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	16						TTATCACCCCGTTCCCCAGCC	0.507000													3	91					0.000602214	0.000669127	0.014758	1	0
PPFIBP1	8496	broad.mit.edu	37	12	27787945	27787945	+	Missense_Mutation	SNP	G	G	T	rs148953958		TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr12:27787945G>T	ENST00000318304.8	+	4	450	c.167G>T	c.(166-168)cGt>cTt	p.R56L	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.R56L|PPFIBP1_ENST00000545334.1_Missense_Mutation_p.R56L|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.R56L|PPFIBP1_ENST00000535047.1_Missense_Mutation_p.R56L|PPFIBP1_ENST00000537927.1_Intron	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	56					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GAAGACCTGCGTGGATTGTTA	0.458000													12	222					0.0809354	0.0837262	0.080935	1	0
LCP1	3936	broad.mit.edu	37	13	46730641	46730641	+	Silent	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr13:46730641C>T	ENST00000398576.2	-	8	811	c.423G>A	c.(421-423)cgG>cgA	p.R141R	LCP1_ENST00000323076.2_Silent_p.R141R			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	141	Actin-binding 1.|CH 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding	p.R141R(1)		breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		GGATGACATGCCGACAATCAG	0.383000			T	BCL6	NHL								5	386					0	0	0.014758	0	0
CHD7	55636	broad.mit.edu	37	8	61767019	61767019	+	Missense_Mutation	SNP	C	C	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr8:61767019C>A	ENST00000423902.2	+	32	7352	c.6873C>A	c.(6871-6873)gaC>gaA	p.D2291E	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2291					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.D2291D(1)		NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACATGGAGGACGGAGATCCTT	0.458000													7	197					8.12818e-05	9.56257e-05	0.029380	1	0
ANXA10	11199	broad.mit.edu	37	4	169108555	169108555	+	Silent	SNP	C	C	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr4:169108555C>A	ENST00000359299.3	+	12	1131	c.945C>A	c.(943-945)gcC>gcA	p.A315A		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	315							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		CACTGCTTGCCATCTGTGCTG	0.338000													38	128					6.68952e-21	8.19125e-21	0.131918	1	0
MUC4	4585	broad.mit.edu	37	3	195507717	195507717	+	Silent	SNP	G	G	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr3:195507717G>T	ENST00000463781.3	-	2	11193	c.10734C>A	c.(10732-10734)tcC>tcA	p.S3578S	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.S3578S|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	376					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.S3578S(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTCACCTGTGGATACTGAGG	0.587000													3	3					0.004672	0.00500571	0.115264	1	0
BMS1P20	96610	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													8	75					0	0	0.058154	0	0
ITGAM	3684	broad.mit.edu	37	16	31308843	31308843	+	Silent	SNP	C	C	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr16:31308843C>A	ENST00000544665.3	+	13	1436	c.1365C>A	c.(1363-1365)gcC>gcA	p.A455A	ITGAM_ENST00000287497.8_Silent_p.A455A	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	455					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						AGATCGGCGCCTACTTCGGGG	0.587000													10	337					0.00010058	0.000116054	0.093190	1	0
PKN3	29941	broad.mit.edu	37	9	131481983	131481983	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr9:131481983G>A	ENST00000291906.4	+	19	2537	c.2144G>A	c.(2143-2145)cGg>cAg	p.R715Q	PKN3_ENST00000485301.1_3'UTR	NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	715	Protein kinase.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						TTCGGGGACCGGACTAGCACC	0.592000													15	434					0	0	0.132662	0	0
RYR1	6261	broad.mit.edu	37	19	39019676	39019676	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr19:39019676G>A	ENST00000355481.4	+	75	11236	c.11105G>A	c.(11104-11106)cGc>cAc	p.R3702H	RYR1_ENST00000359596.3_Missense_Mutation_p.R3707H|RYR1_ENST00000360985.3_Missense_Mutation_p.R3707H	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3707					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.R3707L(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CACTTCAGCCGCACTGCCCTG	0.637000													3	51					0	0	0.115264	0	0
NEK5	341676	broad.mit.edu	37	13	52676276	52676276	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr13:52676276C>G	ENST00000355568.4	-	10	901	c.762G>C	c.(760-762)ttG>ttC	p.L254F		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	254	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		AGGGCCTTTTCAAAATGGAAT	0.423000													10	314					0	0	0.058154	0	0
SMC3	9126	broad.mit.edu	37	10	112358023	112358023	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr10:112358023A>C	ENST00000361804.4	+	20	2369	c.2243A>C	c.(2242-2244)cAg>cCg	p.Q748P		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	748					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		AAGAGGCAGCAGTCAGAGAAA	0.333000													99	108					0	0	0.139131	0	0
TECPR1	25851	broad.mit.edu	37	7	97873932	97873932	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr7:97873932C>T	ENST00000447648.2	-	5	781	c.482G>A	c.(481-483)cGg>cAg	p.R161Q	TECPR1_ENST00000542604.1_Missense_Mutation_p.R82Q|TECPR1_ENST00000379795.3_Missense_Mutation_p.R161Q			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	161						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GATCCACTTCCGGCGCCGCAC	0.577000													4	93					0	0	0.150653	0	0
TTLL1	25809	broad.mit.edu	37	22	43459908	43459908	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr22:43459908G>A	ENST00000331018.7	-	7	898	c.658C>T	c.(658-660)Cgg>Tgg	p.R220W	TTLL1_ENST00000266254.7_Missense_Mutation_p.R220W			O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	220	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		GTGCAGAACCGGCAAAACCCA	0.463000													4	223					0	0	0.150653	0	0
SLC16A13	201232	broad.mit.edu	37	17	6941493	6941493	+	Silent	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr17:6941493C>T	ENST00000308027.6	+	3	674	c.366C>T	c.(364-366)ttC>ttT	p.F122F		NM_201566.2	NP_963860.1	Q7RTY0	MOT13_HUMAN	solute carrier family 16, member 13	122						integral to membrane|plasma membrane	symporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						CTTTGACCTTCGCTCCGACCC	0.587000													48	41					0	0	0.139131	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													8	75					0	0	0.058154	0	0
ZNF516	9658	broad.mit.edu	37	18	74154244	74154244	+	Missense_Mutation	SNP	G	G	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr18:74154244G>T	ENST00000443185.2	-	3	1084	c.767C>A	c.(766-768)gCc>gAc	p.A256D	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A256D(2)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTGGCTGAAGGCCTGGCCACA	0.687000													4	44					0.00024832	0.000281117	0.150653	1	0
ACTR8	93973	broad.mit.edu	37	3	53911743	53911743	+	Missense_Mutation	SNP	A	A	C			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr3:53911743A>C	ENST00000335754.3	-	4	541	c.441T>G	c.(439-441)atT>atG	p.I147M	ACTR8_ENST00000482349.1_Missense_Mutation_p.I36M	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	147					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		AGTGATCTAAAATTGCAGGTC	0.393000													72	123					0	0	0.139131	0	0
PKHD1	5314	broad.mit.edu	37	6	51929825	51929825	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr6:51929825C>T	ENST00000371117.3	-	13	1179	c.904G>A	c.(904-906)Gtg>Atg	p.V302M	PKHD1_ENST00000340994.4_Missense_Mutation_p.V302M	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	302	IPT/TIG 3.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTGGGAGACACGTGTCTAATA	0.443000													38	48					0	0	0.086207	0	0
VCAN	1462	broad.mit.edu	37	5	82834109	82834109	+	Missense_Mutation	SNP	A	A	G			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr5:82834109A>G	ENST00000265077.3	+	8	5852	c.5287A>G	c.(5287-5289)Aca>Gca	p.T1763A	VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000343200.5_Missense_Mutation_p.T776A|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1763	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.T1763A(1)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAATGTAGCTACATCTAGTGA	0.383000													3	257					0	0	0.115264	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81443821	81443821	+	RNA	SNP	C	C	G	rs150975459	by1000genomes	TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr10:81443821C>G	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							GCAGCACCATCGCCTCAGACC	0.612000													3	39					0	0	0.014758	0	0
ANK1	286	broad.mit.edu	37	8	41529890	41529890	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr8:41529890G>A	ENST00000396942.1	-	38	5161	c.5078C>T	c.(5077-5079)aCg>aTg	p.T1693M	ANK1_ENST00000289734.7_Missense_Mutation_p.T1693M|ANK1_ENST00000352337.4_Missense_Mutation_p.T1693M|ANK1_ENST00000347528.4_Missense_Mutation_p.T1693M|ANK1_ENST00000265709.8_Missense_Mutation_p.T1734M|ANK1_ENST00000379758.2_Missense_Mutation_p.T1693M|ANK1_ENST00000396945.1_Missense_Mutation_p.T1693M			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1693	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACTCCTCTCCGTCACCTGACT	0.557000													12	157					0	0	0.105934	0	0
MTHFSD	64779	broad.mit.edu	37	16	86582080	86582080	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr16:86582080G>A	ENST00000322911.6	-	4	388	c.338C>T	c.(337-339)gCc>gTc	p.A113V	MTHFSD_ENST00000568037.1_5'UTR|MTHFSD_ENST00000381214.5_Missense_Mutation_p.A114V|MTHFSD_ENST00000360900.6_Missense_Mutation_p.A114V|MTHFSD_ENST00000543303.2_Missense_Mutation_p.A113V|MTHFSD_ENST00000546093.1_5'UTR	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	114					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						CTGAGAGGTGGCACATTTTCT	0.453000													5	291					0	0	0.021553	0	0
KLK4	9622	broad.mit.edu	37	19	51412533	51412533	+	Silent	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr19:51412533G>A	ENST00000324041.1	-	2	198	c.199C>T	c.(199-201)Ctg>Ttg	p.L67L	KLK4_ENST00000431178.2_Silent_p.L18L	NM_004917.3	NP_004908.3	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4	67	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(8)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		GCGGCTGACAGCACCCACTGC	0.647000													4	274					0	0	0.150653	0	0
HEATR2	54919	broad.mit.edu	37	7	796571	796571	+	Silent	SNP	G	G	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr7:796571G>T	ENST00000297440.6	+	6	1430	c.1410G>T	c.(1408-1410)ccG>ccT	p.P470P	HEATR2_ENST00000313147.5_Silent_p.P470P	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	470							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CCCTCCAGCCGCACCTGGCAG	0.637000													4	33					0.00116845	0.00127467	0.021553	1	0
OPA1	4976	broad.mit.edu	37	3	193384116	193384116	+	Missense_Mutation	SNP	G	G	A			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr3:193384116G>A	ENST00000361510.2	+	28	3044	c.2810G>A	c.(2809-2811)cGt>cAt	p.R937H	OPA1_ENST00000361715.2_Missense_Mutation_p.R901H|OPA1_ENST00000361908.3_Missense_Mutation_p.R919H|OPA1_ENST00000361828.2_Missense_Mutation_p.R900H|OPA1_ENST00000392438.3_Missense_Mutation_p.R882H|OPA1_ENST00000361150.2_Missense_Mutation_p.R883H	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	882					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TTGTTTTGGCGTATACAGCGC	0.358000													4	221					0	0	0.021553	0	0
ZNF563	147837	broad.mit.edu	37	19	12429722	12429722	+	Missense_Mutation	SNP	T	T	C			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr19:12429722T>C	ENST00000293725.5	-	4	1322	c.1117A>G	c.(1117-1119)Acg>Gcg	p.T373A		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGAGATAACGTTTTCCCACAC	0.413000													6	406					0	0	0.021553	0	0
OR51F1	256892	broad.mit.edu	37	11	4791095	4791095	+	Missense_Mutation	SNP	C	C	T			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr11:4791095C>T	ENST00000380383.1	-	1	73	c.74G>A	c.(73-75)gGc>gAc	p.G25D	OR51F1_ENST00000343430.3_Missense_Mutation_p.G18D|MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	18						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCCAGGAATGCCGGTCAACAA	0.458000													3	60					0	0	0.150653	0	0
PRX	57716	broad.mit.edu	37	19	40901891	40901891	+	Missense_Mutation	SNP	C	C	G			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr19:40901891C>G	ENST00000324001.7	-	7	2638	c.2368G>C	c.(2368-2370)Gaa>Caa	p.E790Q	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	790					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCTGCCTGTTCTGCCTTGGTG	0.597000													6	205					0	0	0.021553	0	0
RP11-526A4.1	0	broad.mit.edu	37	4	150544871	150544872	+	RNA	DEL	GT	GT	-	rs113908353		TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr4:150544871_150544872delGT	ENST00000511993.1	-	0	997																											TGAATCCCAGgtgtgtgtgtgt	0.396													3	6	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	65102089	65102092	+	RNA	DEL	GAAA	GAAA	-	rs150892586	by1000genomes	TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr8:65102089_65102092delGAAA	ENST00000524360.1	-	0	128				RP11-32K4.1_ENST00000520365.1_RNA|RP11-32K4.1_ENST00000523191.1_RNA|RP11-32K4.1_ENST00000521958.1_RNA																							aggaaggaaggaaagaaggaagga	0.431													4	6	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89405323	89405326	+	RNA	DEL	TTTA	TTTA	-	rs34562444		TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr11:89405323_89405326delTTTA	ENST00000532352.1	+	0	1114							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						aattatattgtttatttatttttg	0.230													3	5	---	---	---	---					
LARP4	113251	broad.mit.edu	37	12	50831576	50831580	+	Frame_Shift_Del	DEL	TTGTA	TTGTA	-			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr12:50831576_50831580delTTGTA	ENST00000398473.2	+	6	706_710	c.594_598delTTGTA	c.(592-600)cgttfs	p.RCI198fs	LARP4_ENST00000518444.1_Frame_Shift_Del_p.RCI197fs|LARP4_ENST00000347328.5_Frame_Shift_Del_p.RCI198fs|LARP4_ENST00000522085.1_Frame_Shift_Del_p.RCI198fs|LARP4_ENST00000518561.1_Frame_Shift_Del_p.RCI128fs|LARP4_ENST00000293618.8_Frame_Shift_Del_p.RCI198fs|LARP4_ENST00000429001.3_Frame_Shift_Del_p.RCI204fs	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	198	HTH La-type RNA-binding.						nucleotide binding|RNA binding	p.R198R(1)		breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						GTCATAAGCGTTGTATTGTAATTCT	0.332													32	123	---	---	---	---					
TPCN1	53373	broad.mit.edu	37	12	113704096	113704098	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr12:113704096_113704098delCTG	ENST00000550785.1	+	5	734_736	c.565_567delCTG	c.(565-567)del	p.L194del	TPCN1_ENST00000541517.1_In_Frame_Del_p.L194del|TPCN1_ENST00000335509.6_In_Frame_Del_p.L122del|TPCN1_ENST00000392569.4_In_Frame_Del_p.L54del	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	122						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						GGCCACGGCCCTGCTGCTGCTGC	0.640													7	686	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124856836	124856837	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr12:124856836_124856837insG	ENST00000356219.3	-	21	2693_2694	c.2538_2539insC	c.(2536-2541)cccggcfs	p.G847fs	NCOR2_ENST00000405201.1_Frame_Shift_Ins_p.G847fs|NCOR2_ENST00000404621.1_Frame_Shift_Ins_p.G829fs|NCOR2_ENST00000429285.2_Frame_Shift_Ins_p.G829fs|NCOR2_ENST00000404121.2_Frame_Shift_Ins_p.G400fs|NCOR2_ENST00000397355.1_Frame_Shift_Ins_p.G830fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	847					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCCTCAGCCGCGGGGGGCTTCT	0.698													15	68	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22328645	22328646	+	RNA	INS	-	-	T	rs146299092	by1000genomes	TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr18:22328645_22328646insT	ENST00000582650.1	+	0	235																											tccttccttcctccttccctcc	0.485													3	5	---	---	---	---					
CTD-2189E23.1	0	broad.mit.edu	37	19	14392048	14392049	+	RNA	INS	-	-	CCTT	rs71164225		TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr19:14392048_14392049insCCTT	ENST00000592263.1	-	0	292																											ctgcacccagcccttccttcct	0.535													3	3	---	---	---	---					
LA16c-23H5.4	0	broad.mit.edu	37	22	16419352	16419352	+	RNA	DEL	T	T	-			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chr22:16419352delT	ENST00000444162.1	+	0	279																											GAATCGACGATTTTTTTTTTG	0.398													2	4	---	---	---	---					
PLP2	5355	broad.mit.edu	37	X	49028442	49028443	+	Splice_Site	INS	-	-	G			TCGA-B0-5117-01A-01D-1421-08	TCGA-B0-5117-11A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10dbf5bc-9cb3-4d04-806d-cf0ddcc045be	45c68b6b-0bed-424d-9a77-4f87bbaa3649	g.chrX:49028442_49028443insG	ENST00000376327.5	+	1	170_171	c.96_splice	c.e1+1	p.N32_splice	PLP2_ENST00000376322.3_Splice_Site_p.N32_splice	NM_002668.2	NP_002659.1	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic epithelium-enriched)	32	MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity			endometrium(3)|large_intestine(1)|lung(6)|urinary_tract(3)	13						TTTGCTGAGATTGTGAGCGTTC	0.653													13	9	---	---	---	---