Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CRHR1	1394	broad.mit.edu	37	17	43898756	43898756	+	Missense_Mutation	SNP	T	T	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:43898756T>G	ENST00000314537.5	+	4	502	c.277T>G	c.(277-279)Tgg>Ggg	p.W93G	CRHR1_ENST00000293493.7_5'UTR|CRHR1_ENST00000339069.5_Intron|CRHR1_ENST00000352855.5_Missense_Mutation_p.W53G|CRHR1_ENST00000398285.3_Missense_Mutation_p.W93G|CRHR1_ENST00000577353.1_Missense_Mutation_p.W93G	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	93					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		CAATGGCAGCTGGGCCGCCCG	0.642000													6	113					0	0	0.001984	0	0
PCDH11X	27328	broad.mit.edu	37	X	91134175	91134175	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chrX:91134175C>T	ENST00000373094.1	+	2	3781	c.2936C>T	c.(2935-2937)tCc>tTc	p.S979F	PCDH11X_ENST00000361655.2_Missense_Mutation_p.S979F|PCDH11X_ENST00000298274.8_Missense_Mutation_p.S979F|PCDH11X_ENST00000395337.2_Missense_Mutation_p.S979F|PCDH11X_ENST00000406881.1_Missense_Mutation_p.S979F|PCDH11X_ENST00000373088.1_Missense_Mutation_p.S979F|PCDH11X_ENST00000361724.1_Missense_Mutation_p.S979F|PCDH11X_ENST00000373097.1_Missense_Mutation_p.S979F|PCDH11X_ENST00000504220.1_Missense_Mutation_p.S979F	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	979					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GACTCTATCTCCAAGTGTTCC	0.512000													65	141					0	0	0.014410	0	0
PGK2	5232	broad.mit.edu	37	6	49754598	49754598	+	Silent	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr6:49754598G>A	ENST00000304801.3	-	1	455	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	101					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CCACTTCTGCGCCTACACAGT	0.522000													9	116					0	0	0.008291	0	0
NAA25	80018	broad.mit.edu	37	12	112509842	112509842	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr12:112509842G>A	ENST00000261745.4	-	10	1141	c.893C>T	c.(892-894)tCt>tTt	p.S298F		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	298						cytoplasm	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						TTTTTCTGCAGAATAATGTAC	0.393000													12	29					0	0	0.002450	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683027	50683027	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr6:50683027C>G	ENST00000008391.3	+	2	466	c.238C>G	c.(238-240)Cac>Gac	p.H80D		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	80							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					CGAGTTTCAGCACAGCCACCC	0.597000													23	62					0	0	0.012319	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967630	142967630	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chrX:142967630C>T	ENST00000370494.1	+	1	458	c.428C>T	c.(427-429)gCa>gTa	p.A143V		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	143							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGCTAGAGCATGGACTAGG	0.428000													38	107					0	0	0.008740	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													8	44					0	0	0.008291	0	0
TTC39A	22996	broad.mit.edu	37	1	51755792	51755792	+	Splice_Site	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:51755792C>A	ENST00000447632.2	-	16	1535		c.e16-1		TTC39A_ENST00000262675.7_Splice_Site|TTC39A_ENST00000530004.1_Splice_Site|TTC39A_ENST00000371750.5_Splice_Site|TTC39A_ENST00000451380.1_Splice_Site|TTC39A_ENST00000413473.2_Splice_Site|TTC39A_ENST00000534098.1_Splice_Site			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A								binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						TACTCGTTCTCTGAAAATAGG	0.473000													9	31					2.62144e-13	3.33638e-13	0.004482	1	0
CROCCP2	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	T	G	rs10796418	by1000genomes	TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:16946407T>G	ENST00000412962.1	-	0	1112																											AGCAATCTCCTCACTCAGCTG	0.672000													3	31					0	0	0.009096	0	0
PPP3R2	5535	broad.mit.edu	37	9	104357086	104357086	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr9:104357086C>T	ENST00000374806.1	-	1	197	c.127G>A	c.(127-129)Gtg>Atg	p.V43M	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	40	EF-hand 1.						calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AACTCCTCCACGCTCAGAGAC	0.542000													4	79					0	0	0.001984	0	0
CD300A	11314	broad.mit.edu	37	17	72469738	72469738	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:72469738A>C	ENST00000360141.3	+	2	392	c.104A>C	c.(103-105)cAg>cCg	p.Q35P	CD300A_ENST00000392625.3_Intron|CD300A_ENST00000577511.1_5'UTR|CD300A_ENST00000310828.5_Intron|CD300A_ENST00000361933.3_Intron	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	35	Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						CTGAGTGTGCAGTGTCCCTAT	0.542000													29	78					0	0	0.006320	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													8	51					0	0	0.003080	0	0
XPO7	23039	broad.mit.edu	37	8	21839275	21839275	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr8:21839275T>C	ENST00000434536.1	+	10	1120	c.1018T>C	c.(1018-1020)Tgc>Cgc	p.C340R	XPO7_ENST00000433566.4_Missense_Mutation_p.C332R|XPO7_ENST00000252512.9_Missense_Mutation_p.C331R			Q9UIA9	XPO7_HUMAN	exportin 7	331				Missing (in Ref. 3; BAA34465).	mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CCATGAGTTTTGCAGACTACT	0.393000													35	91					0	0	0.013726	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	87					0	0	0.004672	0	0
BRWD1	54014	broad.mit.edu	37	21	40582046	40582046	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr21:40582046T>C	ENST00000342449.3	-	36	4150	c.4072A>G	c.(4072-4074)Atg>Gtg	p.M1358V	BRWD1_ENST00000380800.3_Missense_Mutation_p.M1358V|BRWD1_ENST00000333229.2_Missense_Mutation_p.M1358V	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1358	Bromo 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CCAAAATCCATTGGGGTATCT	0.353000													5	89					0	0	0.000602	0	0
DNAH9	1770	broad.mit.edu	37	17	11809061	11809061	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:11809061C>T	ENST00000262442.3	+	61	11752	c.11684C>T	c.(11683-11685)cCa>cTa	p.P3895L	DNAH9_ENST00000396001.2_Missense_Mutation_p.P207L|DNAH9_ENST00000454412.2_Missense_Mutation_p.P3895L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3895	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAATCGGGACCAGCCACTCCT	0.478000													19	33					0	0	0.014323	0	0
SCGB2A1	4246	broad.mit.edu	37	11	61977950	61977950	+	Nonsense_Mutation	SNP	G	G	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr11:61977950G>T	ENST00000244930.4	+	2	185	c.121G>T	c.(121-123)Gaa>Taa	p.E41*		NM_002407.2	NP_002398.1	O75556	SG2A1_HUMAN	secretoglobin, family 2A, member 1	41						extracellular region	androgen binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)	6						ATCTATACCTGAATACAAAGA	0.398000													41	125					1.8453e-21	2.51165e-21	0.010771	1	0
CNTNAP3	79937	broad.mit.edu	37	9	39109190	39109190	+	Missense_Mutation	SNP	A	A	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr9:39109190A>T	ENST00000297668.6	-	15	2405	c.2332T>A	c.(2332-2334)Tat>Aat	p.Y778N	CNTNAP3_ENST00000358144.2_Missense_Mutation_p.Y690N|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.Y777N	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	778	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CCCAGTGTATAAGCTGCTTCG	0.438000													11	34					0	0	0.008291	0	0
KIAA1109	84162	broad.mit.edu	37	4	123270439	123270439	+	Silent	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr4:123270439G>A	ENST00000264501.4	+	78	13780	c.13407G>A	c.(13405-13407)ggG>ggA	p.G4469G	KIAA1109_ENST00000388738.3_Silent_p.G4469G			Q2LD37	K1109_HUMAN	KIAA1109	4469					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TAGTTGGAGGGACCATAGATG	0.383000													20	55					0	0	0.012319	0	0
MOV10L1	54456	broad.mit.edu	37	22	50552903	50552903	+	Silent	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr22:50552903C>T	ENST00000262794.5	+	7	1061	c.978C>T	c.(976-978)gaC>gaT	p.D326D	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Silent_p.D326D|MOV10L1_ENST00000540615.1_Silent_p.D306D|MOV10L1_ENST00000545383.1_Silent_p.D326D	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	326					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGGATAAAGACCAGATGTGCC	0.368000													18	65					0	0	0.006122	0	0
TGM7	116179	broad.mit.edu	37	15	43572078	43572078	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr15:43572078G>A	ENST00000452443.2	-	10	1427	c.1423C>T	c.(1423-1425)Ccc>Tcc	p.P475S		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	475					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TCCAGGAAGGGCAAAGAAGCT	0.592000													30	110					0	0	0.013726	0	0
LRRC71	149499	broad.mit.edu	37	1	156900360	156900360	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:156900360G>A	ENST00000337428.7	+	12	1434	c.1280G>A	c.(1279-1281)gGg>gAg	p.G427E	LRRC71_ENST00000490146.1_3'UTR	NM_144702.2	NP_653303.2	Q8N4P6	LRC71_HUMAN	leucine rich repeat containing 71	427										endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|stomach(1)	12						AGGGCAAAAGGGATCAAGATC	0.592000													2	3					0	0	0.004672	0	0
SEC24B	10427	broad.mit.edu	37	4	110452560	110452560	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr4:110452560C>A	ENST00000265175.5	+	20	3327	c.3272C>A	c.(3271-3273)aCa>aAa	p.T1091K	SEC24B_ENST00000504968.2_Missense_Mutation_p.T1121K|SEC24B_ENST00000399100.2_Missense_Mutation_p.T1056K	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	1091					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		AGAACGGGTACAAGCACACGG	0.343000													25	78					7.92952e-12	9.71366e-12	0.003954	1	0
C11orf84	144097	broad.mit.edu	37	11	63585351	63585351	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr11:63585351A>G	ENST00000294244.4	+	2	501	c.202A>G	c.(202-204)Aag>Gag	p.K68E		NM_138471.1	NP_612480.1	Q9BUA3	CK084_HUMAN	chromosome 11 open reading frame 84	68										endometrium(3)|kidney(1)|lung(3)|skin(1)	8						TGAGGAGCCGAAGCAGCAGGT	0.667000													10	17					0	0	0.006214	0	0
GNPTAB	79158	broad.mit.edu	37	12	102159997	102159997	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr12:102159997A>C	ENST00000299314.7	-	12	1746	c.1484T>G	c.(1483-1485)tTt>tGt	p.F495C		NM_024312.4	NP_077288.2	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	495	Gly-rich.				cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	37						TCCTCCACCAAACTGCCAGGG	0.498000													40	86					0	0	0.009718	0	0
PAQR5	54852	broad.mit.edu	37	15	69689888	69689888	+	Silent	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr15:69689888C>T	ENST00000340965.3	+	7	1262	c.594C>T	c.(592-594)ctC>ctT	p.L198L	RP11-253M7.1_ENST00000558617.1_RNA|PAQR5_ENST00000561153.1_Silent_p.L198L|PAQR5_ENST00000395407.2_Silent_p.L198L|RP11-253M7.1_ENST00000560539.1_RNA	NM_001104554.1	NP_001098024.1	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	198					cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|skin(1)	11						GGGACTCCCTCCCCATCTTCT	0.522000													21	74					0	0	0.002780	0	0
OR4K14	122740	broad.mit.edu	37	14	20483333	20483333	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr14:20483333G>T	ENST00000305045.2	-	1	19	c.20C>A	c.(19-21)tCc>tAc	p.S7Y		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TGACACCAAGGAATAGTTCTG	0.378000													18	54					8.10497e-08	9.68643e-08	0.010504	1	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													6	12					0	0	0.001984	0	0
PCSK6	5046	broad.mit.edu	37	15	101983760	101983760	+	Splice_Site	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr15:101983760C>A	ENST00000348070.1	-	3	399		c.e3+1		PCSK6_ENST00000561177.1_Splice_Site|PCSK6_ENST00000358417.3_Splice_Site|PCSK6_ENST00000398181.2_Splice_Site|PCSK6_ENST00000344273.2_Splice_Site	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6						glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ACACTCTGTACCTGGGGGTCC	0.453000													7	166					0.00198382	0.00228723	0.001984	1	0
CHGB	1114	broad.mit.edu	37	20	5903084	5903084	+	Silent	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr20:5903084C>T	ENST00000378961.4	+	4	498	c.294C>T	c.(292-294)tcC>tcT	p.S98S		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	98						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CCCACGAGTCCTCCAGCAGGG	0.537000													10	20					0	0	0.006214	0	0
RGAG1	57529	broad.mit.edu	37	X	109694660	109694660	+	Missense_Mutation	SNP	T	T	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chrX:109694660T>A	ENST00000465301.2	+	3	1061	c.815T>A	c.(814-816)aTa>aAa	p.I272K	RGAG1_ENST00000540313.1_Missense_Mutation_p.I272K	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	272										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						TCCTCACTGATAATGTCAGCT	0.498000													6	180					0	0	0.001168	0	0
TEX11	56159	broad.mit.edu	37	X	69774533	69774533	+	Missense_Mutation	SNP	T	T	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chrX:69774533T>G	ENST00000395889.2	-	27	2458	c.2303A>C	c.(2302-2304)cAt>cCt	p.H768P	TEX11_ENST00000344304.3_Missense_Mutation_p.H768P|TEX11_ENST00000374333.2_Missense_Mutation_p.H753P|TEX11_ENST00000374320.2_Missense_Mutation_p.H443P	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	768							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					AGTTTCTAAATGAGGCAACTC	0.368000													17	59					0	0	0.004007	0	0
TTLL6	284076	broad.mit.edu	37	17	46865173	46865173	+	Splice_Site	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:46865173C>T	ENST00000393382.3	-	11	1730	c.1589_splice	c.e11+1	p.R530_splice	TTLL6_ENST00000433608.2_Splice_Site_p.R223_splice	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	482						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GTCTTCCTACCGGGCATACTC	0.542000													39	53					0	0	0.006230	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310052	178310052	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr5:178310052A>C	ENST00000322434.3	+	5	825	c.599A>C	c.(598-600)aAt>aCt	p.N200T		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGAATTCAAATTTACTTAAC	0.318000													33	82					0	0	0.012213	0	0
SIAE	54414	broad.mit.edu	37	11	124543579	124543579	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr11:124543579C>T	ENST00000263593.3	-	1	198	c.26G>A	c.(25-27)gGg>gAg	p.G9E	SIAE_ENST00000545756.1_5'UTR|SIAE_ENST00000525730.1_Intron			Q9HAT2	SIAE_HUMAN	sialic acid acetylesterase	9						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity	p.G9V(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	15	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		CAGCACCAGCCCGAGTACAAG	0.711000													7	15					0	0	0.001984	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39176052	39176052	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr9:39176052C>A	ENST00000297668.6	-	7	1038	c.965G>T	c.(964-966)cGg>cTg	p.R322L	CNTNAP3_ENST00000358144.2_Missense_Mutation_p.R234L|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.R322L|CNTNAP3_ENST00000377653.2_5'UTR|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.R322L|CNTNAP3_ENST00000377659.1_Missense_Mutation_p.R322L	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	322	Laminin G-like 1.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCTGAATGCCCGCGATCTTCC	0.383000													26	85					5.60225e-13	7.03872e-13	0.009535	1	0
CEBPZ	10153	broad.mit.edu	37	2	37450342	37450342	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr2:37450342C>T	ENST00000234170.5	-	3	1997	c.1852G>A	c.(1852-1854)Ggt>Agt	p.G618S		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	618					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				CTTCTTAAACCTGGTTTTGCT	0.348000													5	118					0	0	0.003080	0	0
NUP93	9688	broad.mit.edu	37	16	56852646	56852646	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr16:56852646G>A	ENST00000564887.1	+	4	820	c.191G>A	c.(190-192)cGg>cAg	p.R64Q	NUP93_ENST00000308159.5_Missense_Mutation_p.R187Q|NUP93_ENST00000542526.1_Missense_Mutation_p.R64Q|NUP93_ENST00000569842.1_Missense_Mutation_p.R187Q	NM_001242795.1	NP_001229724.1	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	187					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						GCCTATGCGCGGCAAGTGAGT	0.443000													3	71					0	0	0.009096	0	0
PRSS12	8492	broad.mit.edu	37	4	119273399	119273399	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr4:119273399G>C	ENST00000296498.3	-	1	759	c.477C>G	c.(475-477)gaC>gaG	p.D159E		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	159	Kringle.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						AGTAGCCCCAGTCCACCTTGC	0.687000													5	19					0	0	0.000602	0	0
RPL3	6122	broad.mit.edu	37	22	39711444	39711444	+	Silent	SNP	A	A	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr22:39711444A>T	ENST00000216146.4	-	5	791	c.618T>A	c.(616-618)ccT>ccA	p.P206P	RPL3_ENST00000401609.1_Silent_p.P154P|RPL3_ENST00000465618.1_5'UTR	NM_000967.3|NM_001033853.1	NP_000958.1|NP_001029025.1	P39023	RL3_HUMAN	ribosomal protein L3	206					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(4)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	Melanoma(58;0.04)					CTTGGTTCACAGGTACCTGCT	0.587000													23	66					0	0	0.014323	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								3	33					0	0	0.004672	0	0
ATP8B3	148229	broad.mit.edu	37	19	1809703	1809703	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr19:1809703C>T	ENST00000539485.1	-	4	574	c.341G>A	c.(340-342)cGt>cAt	p.R114H	ATP8B3_ENST00000526092.1_Missense_Mutation_p.R61H|ATP8B3_ENST00000310127.6_Missense_Mutation_p.R114H|ATP8B3_ENST00000525591.1_Missense_Mutation_p.R61H			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	114					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTTGTAGGCACGGTTGTTGGC	0.632000													3	10					0	0	0.004672	0	0
MTOR	2475	broad.mit.edu	37	1	11188164	11188164	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:11188164G>C	ENST00000361445.4	-	43	6006	c.5930C>G	c.(5929-5931)aCa>aGa	p.T1977R	MTOR_ENST00000376838.1_Missense_Mutation_p.T182R	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1977	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity	p.T1977R(2)|p.T1977K(1)		breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						AGAAGCCACTGTCAGTGGGTA	0.478000													40	141					0	0	0.014410	0	0
ZC3H12D	340152	broad.mit.edu	37	6	149773757	149773757	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr6:149773757G>T	ENST00000389942.5	-	5	1029	c.782C>A	c.(781-783)cCt>cAt	p.P261H	ZC3H12D_ENST00000409806.3_Missense_Mutation_p.P261H|ZC3H12D_ENST00000542614.1_Missense_Mutation_p.P261H|ZC3H12D_ENST00000416573.2_Missense_Mutation_p.P261H			A2A288	ZC12D_HUMAN	zinc finger CCCH-type containing 12D	261						cytoplasm|nucleus	endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.23e-11)|GBM - Glioblastoma multiforme(68;0.0921)		CCCACCATAAGGACAATGCTG	0.632000													7	9					8.12818e-05	9.48288e-05	0.001984	1	0
EPS15L1	58513	broad.mit.edu	37	19	16528867	16528867	+	Silent	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr19:16528867G>A	ENST00000602009.1	-	5	1432	c.537C>T	c.(535-537)ttC>ttT	p.F179F	EPS15L1_ENST00000597937.1_Silent_p.F333F|EPS15L1_ENST00000535753.2_Silent_p.F333F|EPS15L1_ENST00000455140.2_Silent_p.F333F|EPS15L1_ENST00000248070.6_Silent_p.F333F|EPS15L1_ENST00000594975.1_Silent_p.F333F			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	333	EF-hand.|EH 2.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						TAGCTAACGCGAATTGGTCTT	0.557000											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	53					0	0	0.007413	0	0
QRSL1	55278	broad.mit.edu	37	6	107102774	107102774	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr6:107102774C>T	ENST00000369046.4	+	8	1123	c.1019C>T	c.(1018-1020)gCa>gTa	p.A340V		NM_018292.4	NP_060762.3	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	340					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor			endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		TCGAATATGGCAAGATTTGAT	0.378000													6	188					0	0	0.001984	0	0
ZNF536	9745	broad.mit.edu	37	19	30936076	30936076	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr19:30936076G>T	ENST00000355537.3	+	2	1754	c.1607G>T	c.(1606-1608)gGc>gTc	p.G536V		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	536					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ATGGAACATGGCTTCTTGTCT	0.587000													22	82					1.36565e-18	1.78444e-18	0.002780	1	0
KIAA1257	57501	broad.mit.edu	37	3	128694691	128694691	+	Missense_Mutation	SNP	T	T	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr3:128694691T>A	ENST00000265068.5	-	7	1119	c.952A>T	c.(952-954)Atc>Ttc	p.I318F	KIAA1257_ENST00000515659.1_Missense_Mutation_p.I206F|KIAA1257_ENST00000511438.1_Missense_Mutation_p.I318F	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	318										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						AATTCCTTGATCTCCATCATG	0.338000													3	31					0	0	0.004672	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687088	68687088	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr10:68687088G>C	ENST00000361320.4	+	2	992	c.414G>C	c.(412-414)ttG>ttC	p.L138F	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	138						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TACGGAACTTGGATCTGTCCT	0.418000													4	236					0	0	0.001168	0	0
LARP6	55323	broad.mit.edu	37	15	71124409	71124409	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr15:71124409C>A	ENST00000299213.8	-	3	1528	c.1458G>T	c.(1456-1458)agG>agT	p.R486S		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	486					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						AGGCCCTGCTCCTCTCATGGC	0.502000													42	153					1.23713e-20	1.6608e-20	0.014410	1	0
SLC34A2	10568	broad.mit.edu	37	4	25664146	25664146	+	Silent	SNP	A	A	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr4:25664146A>G	ENST00000382051.3	+	2	74	c.24A>G	c.(22-24)ggA>ggG	p.G8G	SLC34A2_ENST00000504570.1_Silent_p.G8G|SLC34A2_ENST00000503434.1_Silent_p.G8G	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	8					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				CTGAATTGGGAGATGCCCAGC	0.532000			T	ROS1	NSCLC								18	55					0	0	0.007413	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413493	105413493	+	Silent	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr14:105413493C>T	ENST00000333244.5	-	7	8414	c.8295G>A	c.(8293-8295)gcG>gcA	p.A2765A	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2765						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGTCACTTCCGCCTTGGGGC	0.612000													68	159					0	0	0.014410	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113793	42113793	+	Silent	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr15:42113793C>A	ENST00000457542.2	+	24	3016	c.2730C>A	c.(2728-2730)ccC>ccA	p.P910P	MAPKBP1_ENST00000514566.1_Silent_p.P910P|MAPKBP1_ENST00000456763.2_Silent_p.P916P|MAPKBP1_ENST00000260357.7_Silent_p.P749P|MAPKBP1_ENST00000221214.6_Silent_p.P793P	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	916										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ATGAAAAGCCCCCTCGGCCTC	0.537000													7	114					0.00448238	0.00510783	0.004482	1	0
CEACAM5	1048	broad.mit.edu	37	19	42221598	42221598	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr19:42221598A>C	ENST00000221992.6	+	5	1297	c.1183A>C	c.(1183-1185)Atc>Ctc	p.I395L	CEACAM5_ENST00000398599.4_Missense_Mutation_p.I394L|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Missense_Mutation_p.I395L	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	395	Ig-like 4.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TGAGTGTGGAATCCAGAACAA	0.522000													47	144					0	0	0.014410	0	0
ZNHIT6	54680	broad.mit.edu	37	1	86146557	86146557	+	Silent	SNP	G	G	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:86146557G>C	ENST00000431532.2	-	7	1081	c.933C>G	c.(931-933)ctC>ctG	p.L311L	ZNHIT6_ENST00000370574.3_Silent_p.L350L	NM_001170670.1|NM_017953.3	NP_001164141.1|NP_060423.3	Q9NWK9	BCD1_HUMAN	zinc finger, HIT-type containing 6	350					box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			autonomic_ganglia(1)|breast(2)|cervix(2)|large_intestine(10)|lung(1)|urinary_tract(1)	17						GAGGAAACTGGAGCTTCACAT	0.318000													18	52					0	0	0.014323	0	0
INTS12	57117	broad.mit.edu	37	4	106603970	106603970	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr4:106603970A>C	ENST00000451321.2	-	7	1788	c.1309T>G	c.(1309-1311)Tca>Gca	p.S437A	INTS12_ENST00000394735.1_Missense_Mutation_p.S437A|INTS12_ENST00000340139.5_Missense_Mutation_p.S437A	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	437	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GATTCTTGTGAAGTTGGGCCT	0.438000													57	157					0	0	0.014410	0	0
SV2A	9900	broad.mit.edu	37	1	149877444	149877444	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:149877444G>A	ENST00000369146.3	-	12	2523	c.2033C>T	c.(2032-2034)cCc>cTc	p.P678L	SV2A_ENST00000369145.1_Missense_Mutation_p.P678L	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	678					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CTTGTCTGAGGGGTAGAGTTC	0.567000													67	184					0	0	0.014410	0	0
LY6E	4061	broad.mit.edu	37	8	144102375	144102375	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr8:144102375G>T	ENST00000520466.1	+	3	422	c.19G>T	c.(19-21)Gtg>Ttg	p.V7L	LY6E_ENST00000522024.1_Missense_Mutation_p.V7L|LY6E_ENST00000519546.1_Missense_Mutation_p.V7L|LY6E_ENST00000521699.1_Missense_Mutation_p.V7L|LY6E_ENST00000520531.1_Missense_Mutation_p.V7L|LY6E_ENST00000521182.1_Missense_Mutation_p.V7L|LY6E_ENST00000292494.6_Missense_Mutation_p.V7L|LY6E_ENST00000523847.1_Missense_Mutation_p.V7L|LY6E_ENST00000429120.2_Missense_Mutation_p.V7L|LY6E_ENST00000521003.1_Missense_Mutation_p.V7L|LY6E_ENST00000519611.1_Missense_Mutation_p.V7L|LY6E_ENST00000517503.1_Missense_Mutation_p.S101I|LY6E_ENST00000522528.1_Missense_Mutation_p.V7L|LY6E_ENST00000522971.1_Missense_Mutation_p.V7L			Q16553	LY6E_HUMAN	lymphocyte antigen 6 complex, locus E	7					cell surface receptor linked signaling pathway	anchored to membrane|integral to plasma membrane				endometrium(1)|kidney(3)|large_intestine(2)|lung(1)	7	all_cancers(97;1.94e-10)|all_epithelial(106;1.22e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CTTCTTGCCAGTGCTGCTGGC	0.612000													12	51					4.14922e-12	5.14713e-12	0.004007	1	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													3	27					0	0	0.004672	0	0
CYP4F11	57834	broad.mit.edu	37	19	16032977	16032977	+	Splice_Site	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr19:16032977C>A	ENST00000326742.7	-	8	987		c.e8-1		CYP4F11_ENST00000402119.3_Splice_Site|CYP4F11_ENST00000248041.7_Splice_Site			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11						inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GTGTCATGGCCTGAGGGGCAG	0.567000													18	42					1.55795e-14	2.00893e-14	0.012319	1	0
DPYD	1806	broad.mit.edu	37	1	98348868	98348868	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:98348868C>G	ENST00000370192.3	-	2	202	c.102G>C	c.(100-102)aaG>aaC	p.K34N	DPYD_ENST00000306031.5_Missense_Mutation_p.K34N|DPYD_ENST00000423006.2_Intron	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	34					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGTCTAATTTCTTGGCCGAAG	0.368000													21	73					0	0	0.004656	0	0
TRIM24	8805	broad.mit.edu	37	7	138268636	138268636	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr7:138268636G>C	ENST00000343526.4	+	18	3050	c.2835G>C	c.(2833-2835)ttG>ttC	p.L945F	TRIM24_ENST00000415680.2_Missense_Mutation_p.L911F			O15164	TIF1A_HUMAN	tripartite motif containing 24	945	Bromo.				cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						CAATGGATTTGTCAACCATCA	0.284000													22	59					0	0	0.002780	0	0
IZUMO2	126123	broad.mit.edu	37	19	50657913	50657913	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr19:50657913C>G	ENST00000293405.3	-	6	567	c.567G>C	c.(565-567)ttG>ttC	p.L189F		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	189						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						TGAGGATGCCCAACAGCGCCT	0.617000													24	73					0	0	0.006320	0	0
PITX2	5308	broad.mit.edu	37	4	111539370	111539370	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr4:111539370T>C	ENST00000354925.2	-	7	2570	c.865A>G	c.(865-867)Aag>Gag	p.K289E	PITX2_ENST00000394595.3_3'UTR|PITX2_ENST00000355080.5_Missense_Mutation_p.K243E|PITX2_ENST00000306732.3_Missense_Mutation_p.K296E|PITX2_ENST00000394598.2_Missense_Mutation_p.K289E	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	289					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GAGTGCTGCTTTGCTTTCAGT	0.637000													15	32					0	0	0.006122	0	0
HYDIN	54768	broad.mit.edu	37	16	71212850	71212850	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr16:71212850A>G	ENST00000393567.2	-	4	512	c.362T>C	c.(361-363)aTt>aCt	p.I121T	HYDIN_ENST00000448089.2_Missense_Mutation_p.I121T|HYDIN_ENST00000541601.1_Missense_Mutation_p.I138T|HYDIN_ENST00000448691.1_Missense_Mutation_p.I121T|HYDIN_ENST00000393550.2_Missense_Mutation_p.I121T|HYDIN_ENST00000538248.1_Missense_Mutation_p.I148T|HYDIN_ENST00000288168.10_Missense_Mutation_p.I138T|HYDIN_ENST00000321489.5_Missense_Mutation_p.I121T	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	121										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GTTCCTCAAAATCAGTGGAAC	0.398000													56	127					0	0	0.014410	0	0
LRRC19	64922	broad.mit.edu	37	9	26997769	26997769	+	Silent	SNP	T	T	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr9:26997769T>G	ENST00000380055.5	-	3	662	c.552A>C	c.(550-552)ctA>ctC	p.L184L	IFT74_ENST00000429045.2_Intron|IFT74_ENST00000443698.1_Intron|IFT74_ENST00000433700.1_Intron|IFT74_ENST00000380062.5_Intron	NM_022901.2	NP_075052.1	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19	184	LRRCT.					integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)	6		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		GCAAATTAAATAGACTGCAAG	0.343000													21	69					0	0	0.008871	0	0
MORF4L1	10933	broad.mit.edu	37	15	79187218	79187218	+	Missense_Mutation	SNP	T	T	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr15:79187218T>G	ENST00000331268.5	+	12	1180	c.976T>G	c.(976-978)Tta>Gta	p.L326V	MORF4L1_ENST00000426013.2_Missense_Mutation_p.L287V|MORF4L1_ENST00000379535.4_Missense_Mutation_p.L312V|MORF4L1_ENST00000558502.1_Missense_Mutation_p.L199V|MORF4L1_ENST00000559345.1_Missense_Mutation_p.L199V|MORF4L1_ENST00000561171.1_3'UTR|MORF4L1_ENST00000558746.1_Missense_Mutation_p.L260V	NM_206839.2	NP_996670.1	Q9UBU8	MO4L1_HUMAN	mortality factor 4 like 1	326	Interaction with RB1-2.|Sufficient for interaction with PHF12.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding			breast(1)|large_intestine(3)|lung(4)|prostate(1)|urinary_tract(1)	10						CCTTGCTTTATTACTCAATTA	0.368000													20	75					0	0	0.012319	0	0
RAB4A	5867	broad.mit.edu	37	1	229434801	229434801	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:229434801C>G	ENST00000366690.4	+	6	731	c.523C>G	c.(523-525)Ctt>Gtt	p.L175V	RAB4A_ENST00000473894.1_3'UTR	NM_004578.2	NP_004569.2	P20338	RAB4A_HUMAN	RAB4A, member RAS oncogene family	170							GDP binding|GTP binding|GTPase activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.178)				AAGAAAAATACTTAACAAAAT	0.348000													3	79					0	0	0.004672	0	0
TET1	80312	broad.mit.edu	37	10	70450720	70450720	+	Missense_Mutation	SNP	A	A	G			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr10:70450720A>G	ENST00000373644.4	+	12	5769	c.5560A>G	c.(5560-5562)Act>Gct	p.T1854A		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1854					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						GTCCCCGAAGACTGCTTCAGC	0.512000													28	85					0	0	0.006320	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802866	24802866	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr16:24802866C>A	ENST00000395799.3	+	6	3032	c.2903C>A	c.(2902-2904)aCa>aAa	p.T968K	TNRC6A_ENST00000315183.7_Missense_Mutation_p.T968K	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	968	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CCTCCTGGTACAGGCTGGCTG	0.527000													19	59					3.32936e-07	3.93105e-07	0.006122	1	0
CYP4F11	57834	broad.mit.edu	37	19	16032978	16032978	+	Splice_Site	SNP	T	T	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr19:16032978T>A	ENST00000326742.7	-	8	987		c.e8-2		CYP4F11_ENST00000402119.3_Splice_Site|CYP4F11_ENST00000248041.7_Splice_Site			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11						inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						TGTCATGGCCTGAGGGGCAGC	0.567000													18	41					0	0	0.010504	0	0
FAM168A	23201	broad.mit.edu	37	11	73120706	73120706	+	Splice_Site	SNP	C	C	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr11:73120706C>A	ENST00000064778.4	-	7	732	c.447_splice	c.e7-1	p.G150_splice	FAM168A_ENST00000450446.2_Intron|RP11-809N8.4_ENST00000536855.1_RNA|FAM168A_ENST00000356467.4_Splice_Site_p.G141_splice|RP11-809N8.4_ENST00000542598.1_RNA			Q92567	F168A_HUMAN	family with sequence similarity 168, member A	150										endometrium(3)|kidney(1)|lung(1)	5						TAGTAGGCTCCCTGGGGGAAA	0.582000													28	73					8.88839e-20	1.17711e-19	0.010818	1	0
LRP2	4036	broad.mit.edu	37	2	169993944	169993944	+	Nonsense_Mutation	SNP	G	G	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr2:169993944G>C	ENST00000263816.3	-	76	13863	c.13578C>G	c.(13576-13578)taC>taG	p.Y4526*		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4526					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTCTGGCTGAGTACATTGGGT	0.438000													24	81					0	0	0.004656	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													3	29					0	0	0.004672	0	0
GPR149	344758	broad.mit.edu	37	3	154147212	154147212	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr3:154147212T>C	ENST00000389740.2	-	1	292	c.193A>G	c.(193-195)Act>Gct	p.T65A		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	65						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GACACAACAGTTCTGTTCTGC	0.463000													6	102					0	0	0.001168	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720917	140720917	+	Silent	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr5:140720917G>A	ENST00000394576.2	+	1	2379	c.2379G>A	c.(2377-2379)gcG>gcA	p.A793A	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTATCAGCGCCTCAATCTC	0.453000													6	108					0	0	0.001984	0	0
UBE3B	89910	broad.mit.edu	37	12	109939265	109939265	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr12:109939265G>A	ENST00000342494.3	+	13	1803	c.1208G>A	c.(1207-1209)aGc>aAc	p.S403N	UBE3B_ENST00000535900.1_3'UTR|UBE3B_ENST00000280774.5_Missense_Mutation_p.S403N|UBE3B_ENST00000434735.2_Missense_Mutation_p.S403N	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	403					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GACATCCTGAGCAAGAAGCTA	0.567000													31	90					0	0	0.009535	0	0
LRCH4	4034	broad.mit.edu	37	7	100175156	100175156	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr7:100175156G>A	ENST00000310300.6	-	10	1194	c.1142C>T	c.(1141-1143)cCt>cTt	p.P381L	LRCH4_ENST00000497245.1_5'UTR	NM_002319.3	NP_002310.2	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 4	381					nervous system development	PML body	protein binding			NS(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	23	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCTGCCCCAGGGCTTAATTC	0.672000													25	91					0	0	0.004656	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52912272	52912272	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr1:52912272delG	ENST00000371544.3	-	21	3765	c.3503delC	c.(3502-3504)aafs	p.T1168fs	ZCCHC11_ENST00000257177.4_Frame_Shift_Del_p.T1168fs	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1168					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						CAGTTCTTCTGTTTTATCAAA	0.269													15	55	---	---	---	---					
PBRM1	55193	broad.mit.edu	37	3	52692214	52692214	+	Splice_Site	DEL	C	C	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr3:52692214delC	ENST00000356770.4	-	5	648		c.e5+1		PBRM1_ENST00000296302.7_Splice_Site|PBRM1_ENST00000394830.3_Splice_Site|PBRM1_ENST00000410007.1_Splice_Site|PBRM1_ENST00000409767.1_Splice_Site|PBRM1_ENST00000409057.1_Splice_Site|PBRM1_ENST00000337303.4_Splice_Site|PBRM1_ENST00000409114.3_Splice_Site			Q86U86	PB1_HUMAN	polybromo 1						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GCATCACTTACCACTTTAGAA	0.358			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								22	75	---	---	---	---					
PDCD10	11235	broad.mit.edu	37	3	167414854	167414854	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr3:167414854delT	ENST00000392750.2	-	5	628	c.211delA	c.(211-213)gcfs	p.S71fs	PDCD10_ENST00000461494.1_Frame_Shift_Del_p.S71fs|PDCD10_ENST00000487947.2_Frame_Shift_Del_p.S71fs|PDCD10_ENST00000470131.1_Frame_Shift_Del_p.S71fs|PDCD10_ENST00000492396.1_Frame_Shift_Del_p.S8fs|PDCD10_ENST00000471885.1_Frame_Shift_Del_p.S71fs|PDCD10_ENST00000473645.2_Frame_Shift_Del_p.S71fs|PDCD10_ENST00000497056.2_Frame_Shift_Del_p.S71fs	NM_007217.3	NP_009148.2	Q9BUL8	PDC10_HUMAN	programmed cell death 10	71					angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding	p.S71fs*18(1)		central_nervous_system(1)|kidney(1)|lung(8)|urinary_tract(2)	12						ACTTCCACGCTTTTTTTCTCT	0.343													30	90	---	---	---	---					
SDHAP1	255812	broad.mit.edu	37	3	195698244	195698246	+	RNA	DEL	CAA	CAA	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr3:195698244_195698246delCAA	ENST00000427841.1	-	0	1626_1628					NR_003264.2																						CTTCCATCAGCAAATCTCAATTT	0.448													7	81	---	---	---	---					
RIMS1	22999	broad.mit.edu	37	6	72960628	72960628	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr6:72960628delA	ENST00000264839.7	+	14	2377	c.2377delA	c.(2377-2379)aafs	p.K793fs	RIMS1_ENST00000348717.5_Frame_Shift_Del_p.K793fs|RIMS1_ENST00000521978.1_Frame_Shift_Del_p.K793fs|RIMS1_ENST00000518273.1_Frame_Shift_Del_p.K793fs|RIMS1_ENST00000425662.2_Frame_Shift_Del_p.K186fs|RIMS1_ENST00000517827.1_Frame_Shift_Del_p.K252fs|RIMS1_ENST00000520567.1_Frame_Shift_Del_p.K793fs|RIMS1_ENST00000523963.1_Frame_Shift_Del_p.K267fs|RIMS1_ENST00000517960.1_Frame_Shift_Del_p.K793fs|RIMS1_ENST00000491071.2_Frame_Shift_Del_p.K793fs|RIMS1_ENST00000522291.1_Frame_Shift_Del_p.K793fs|RIMS1_ENST00000401910.3_Frame_Shift_Del_p.K267fs			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	793	C2 1.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TTTCAGTGATAAAAGTAAAAG	0.294													2	4	---	---	---	---					
ZNF395	55893	broad.mit.edu	37	8	28210125	28210126	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr8:28210125_28210126delCA	ENST00000344423.5	-	6	1015_1016	c.884_885delTG	c.(883-885)gfs	p.V295fs	ZNF395_ENST00000523202.1_Frame_Shift_Del_p.V295fs|ZNF395_ENST00000523095.1_Frame_Shift_Del_p.V295fs	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	295					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.V295V(1)		cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GTTTGATGCCCACAATGGAGCG	0.564													13	71	---	---	---	---					
OR1L1	26737	broad.mit.edu	37	9	125423916	125423919	+	Frame_Shift_Del	DEL	GAGA	GAGA	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr9:125423916_125423919delGAGA	ENST00000373686.1	+	1	72_75	c.72_75delGAGA	c.(70-75)agfs	p.RR24fs				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R25I(1)		breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						AGAATAAAAGGAGAAATTTTGGAC	0.294													13	66	---	---	---	---					
TRIM6	117854	broad.mit.edu	37	11	5632212	5632216	+	Frame_Shift_Del	DEL	GGGGG	GGGGG	-	rs10769124	byFrequency	TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr11:5632212_5632216delGGGGG	ENST00000380097.3	+	8	1433_1437	c.1191_1195delGGGGG	c.(1189-1197)cttafs	p.LGV397fs	TRIM6_ENST00000506134.1_Frame_Shift_Del_p.LGV194fs|TRIM6_ENST00000507320.1_Frame_Shift_Del_p.LGV194fs|TRIM6_ENST00000481603.1_3'UTR|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000445329.1_Frame_Shift_Del_p.LGV194fs|HBG2_ENST00000380259.2_Intron|TRIM6_ENST00000278302.5_Frame_Shift_Del_p.LGV369fs|TRIM6_ENST00000380107.1_Frame_Shift_Del_p.LGV343fs|TRIM6-TRIM34_ENST00000354852.5_Intron|TRIM6_ENST00000515022.1_Frame_Shift_Del_p.LGV194fs	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCTGGATCCTGGGGGTATGCAGCAA	0.488													37	104	---	---	---	---					
CSTF3	1479	broad.mit.edu	37	11	33107506	33107506	+	Frame_Shift_Del	DEL	C	C	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr11:33107506delC	ENST00000323959.4	-	19	1964	c.1825delG	c.(1825-1827)tgfs	p.V609fs	TCP11L1_ENST00000324357.9_Intron	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	609	Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						ACTGGGAACACTCCACCAGGT	0.423													7	23	---	---	---	---					
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	CGGAGT	-	rs55725290		TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr11:124750448_124750453delCGGAGT	ENST00000397801.1	+	27	4285_4290	c.4093_4098delCGGAGT	c.(4093-4098)del	p.RS1367del	ROBO3_ENST00000543966.1_In_Frame_Del_p.RS130del|ROBO3_ENST00000538940.1_In_Frame_Del_p.RS1345del|ROBO3_ENST00000525482.1_3'UTR	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1367					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.660													4	4	---	---	---	---					
G6PC	2538	broad.mit.edu	37	17	41063346	41063346	+	Frame_Shift_Del	DEL	C	C	-	rs80356486		TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:41063346delC	ENST00000253801.2	+	5	1056	c.977delC	c.(976-978)tcfs	p.S326fs	G6PC_ENST00000585489.1_3'UTR|G6PC_ENST00000592383.1_3'UTR	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	326					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TACGTCTTGTCCTTCTGCAAG	0.582													66	172	---	---	---	---					
NBR1	4077	broad.mit.edu	37	17	41341765	41341766	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:41341765_41341766delAT	ENST00000422280.1	+	8	1100_1101	c.641_642delAT	c.(640-642)cfs	p.H214fs	NBR1_ENST00000589872.1_Frame_Shift_Del_p.H214fs|NBR1_ENST00000389312.4_Frame_Shift_Del_p.H214fs|NBR1_ENST00000341165.6_Frame_Shift_Del_p.H214fs|NBR1_ENST00000590996.1_Frame_Shift_Del_p.H214fs|NBR1_ENST00000542611.1_Frame_Shift_Del_p.H193fs	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	214					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		TTCAGCTGGCATATTGCTTGCA	0.465													74	198	---	---	---	---					
ANKFN1	162282	broad.mit.edu	37	17	54535324	54535325	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr17:54535324_54535325insAA	ENST00000566473.2	+	13	1550_1551	c.1550_1551insAA	c.(1549-1551)gacfs	p.D517fs	ANKFN1_ENST00000318698.2_Frame_Shift_Ins_p.D517fs			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	517								p.A517E(1)		NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						ATGCTCGCAGCAACAGCACAGC	0.460													18	37	---	---	---	---					
PLXNB2	23654	broad.mit.edu	37	22	50728367	50728370	+	Frame_Shift_Del	DEL	TGTG	TGTG	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chr22:50728367_50728370delTGTG	ENST00000449103.1	-	3	784_787	c.644_647delCACA	c.(643-648)agfs	p.TQ215fs	PLXNB2_ENST00000359337.4_Frame_Shift_Del_p.TQ215fs			O15031	PLXB2_HUMAN	plexin B2	215	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CACGAACTGCTGTGTGTTGGTGGA	0.627													10	59	---	---	---	---					
ATRX	546	broad.mit.edu	37	X	76919038	76919038	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B4-5844-01A-11D-1669-08	TCGA-B4-5844-10A-01D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5e5aea05-4ff2-43ea-a516-26dcef52b132	773f9a87-7513-4ac8-a8a3-833470984fb4	g.chrX:76919038delT	ENST00000373344.5	-	12	4167	c.3953delA	c.(3952-3954)atfs	p.N1318fs	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Frame_Shift_Del_p.N1280fs	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1318					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	ATTGACTTGATTTTTTGCTTC	0.353			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						13	33	---	---	---	---