Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RRN3P1	730092	broad.mit.edu	37	16	21817523	21817523	+	RNA	SNP	T	T	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr16:21817523T>C	ENST00000546471.1	-	0	1535																											TATACACTAATCCTTAGTAAG	0.284000													6	32					0	0	0.217242	0	0
C20orf26	26074	broad.mit.edu	37	20	20180478	20180478	+	Missense_Mutation	SNP	C	C	G	rs147638085		TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr20:20180478C>G	ENST00000245957.5	+	17	1940	c.1864C>G	c.(1864-1866)Cga>Gga	p.R622G	C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	622										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		GCGACCACGACGACAGATTGT	0.557000													4	236					0	0	0.150653	0	0
GPR124	25960	broad.mit.edu	37	8	37699044	37699044	+	Missense_Mutation	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr8:37699044T>A	ENST00000315215.7	+	16	2900	c.2537T>A	c.(2536-2538)cTc>cAc	p.L846H	GPR124_ENST00000412232.2_Missense_Mutation_p.L1063H			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	1063					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCCCTGGGCCTCTTCGTCTTC	0.731000													10	24					0	0	0.335167	0	0
WDR47	22911	broad.mit.edu	37	1	109554274	109554274	+	Missense_Mutation	SNP	C	C	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:109554274C>G	ENST00000357672.3	-	4	685	c.310G>C	c.(310-312)Gat>Cat	p.D104H	WDR47_ENST00000369962.3_Missense_Mutation_p.D132H|WDR47_ENST00000369965.4_Missense_Mutation_p.D132H|WDR47_ENST00000400794.3_Missense_Mutation_p.D139H|WDR47_ENST00000361054.3_Missense_Mutation_p.D104H			O94967	WDR47_HUMAN	WD repeat domain 47	132										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CTATAGTCATCTTTAGAAGGA	0.393000													8	233					0	0	0.307466	0	0
SAMD9	54809	broad.mit.edu	37	7	92732890	92732890	+	Missense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr7:92732890G>T	ENST00000379958.2	-	3	2790	c.2521C>A	c.(2521-2523)Cct>Act	p.P841T		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	841						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTTTTTCAGGATTTTGTGAT	0.358000													24	144					9.86323e-18	1.17472e-17	0.667858	1	0
TRIM51HP	440041	broad.mit.edu	37	11	55063124	55063124	+	RNA	SNP	G	G	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr11:55063124G>C	ENST00000526016.1	-	0	513					NR_038174.2																						GGCATCTTCTGATATTCAGCT	0.378000													8	44					0	0	0.307466	0	0
FAT4	79633	broad.mit.edu	37	4	126242308	126242308	+	Missense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr4:126242308G>T	ENST00000394329.3	+	1	4755	c.4742G>T	c.(4741-4743)aGt>aTt	p.S1581I		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1581	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GATCGTTATAGTGGAGACCTG	0.458000													40	173					3.54561e-26	4.31993e-26	0.847076	1	0
CCDC151	115948	broad.mit.edu	37	19	11537537	11537537	+	Missense_Mutation	SNP	G	G	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr19:11537537G>C	ENST00000356392.4	-	5	767	c.680C>G	c.(679-681)aCc>aGc	p.T227S	CCDC151_ENST00000591179.1_Intron|CCDC151_ENST00000545100.1_Missense_Mutation_p.T173S|CCDC151_ENST00000586836.1_Missense_Mutation_p.T36S	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	227										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						GTACACGCTGGTAATGTGCTC	0.622000													10	35					0	0	0.335167	0	0
CECR1	51816	broad.mit.edu	37	22	17662885	17662885	+	Missense_Mutation	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr22:17662885T>A	ENST00000399839.1	-	9	1537	c.1267A>T	c.(1267-1269)Aac>Tac	p.N423Y	CECR1_ENST00000262607.3_Missense_Mutation_p.N423Y|CECR1_ENST00000330232.4_Missense_Mutation_p.N182Y|CECR1_ENST00000399837.2_Missense_Mutation_p.N423Y|CECR1_ENST00000449907.2_Missense_Mutation_p.N381Y			Q9NZK5	CECR1_HUMAN	cat eye syndrome chromosome region, candidate 1	423					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				ACAGGGTGGTTCCTCAAGTCA	0.507000													11	68					0	0	0.361761	0	0
LOC101927755	101927755	broad.mit.edu	37	17	58066651	58066651	+	RNA	SNP	C	C	T	rs144367363	by1000genomes	TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr17:58066651C>T	ENST00000586209.1	+	0	158																											ACTGGTAAAGCTGTTTAAGAG	0.333000													4	23					0	0	0.150653	0	0
TXNIP	10628	broad.mit.edu	37	1	145440991	145440991	+	Missense_Mutation	SNP	G	G	C	rs150987946	byFrequency	TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:145440991G>C	ENST00000369317.4	+	7	1412	c.1078G>C	c.(1078-1080)Gac>Cac	p.D360H	TXNIP_ENST00000475171.1_Intron	NM_006472.3	NP_006463.3	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	360					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(1)|lung(5)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	21	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGCTCTCAAGACAGCCCTAT	0.453000													4	255					0	0	0.150653	0	0
TENM1	10178	broad.mit.edu	37	X	124030083	124030083	+	Silent	SNP	T	T	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chrX:124030083T>C	ENST00000422452.2	-	2	288	c.225A>G	c.(223-225)gaA>gaG	p.E75E	TENM1_ENST00000371130.3_Silent_p.E75E	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTTCACAGAATTCCATCTCTG	0.448000													52	89					0	0	0.870114	0	0
PTPRF	5792	broad.mit.edu	37	1	44035299	44035299	+	Missense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:44035299G>T	ENST00000359947.4	+	6	758	c.418G>T	c.(418-420)Ggg>Tgg	p.G140W	PTPRF_ENST00000372413.3_Missense_Mutation_p.G140W|PTPRF_ENST00000372414.3_Missense_Mutation_p.G140W|PTPRF_ENST00000438120.1_Missense_Mutation_p.G140W	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	140	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CATCGACATGGGGCCTCAGCT	0.577000													4	116					0.00909568	0.0092706	0.150653	1	0
OCA2	4948	broad.mit.edu	37	15	28230225	28230225	+	Missense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr15:28230225G>T	ENST00000354638.3	-	13	1504	c.1349C>A	c.(1348-1350)aCg>aAg	p.T450K	OCA2_ENST00000382996.2_Missense_Mutation_p.T450K|OCA2_ENST00000353809.5_Missense_Mutation_p.T426K	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	450					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GGTCACAGGCGTGAAGAGGAG	0.622000									Oculocutaneous Albinism				9	52					6.40141e-05	6.85404e-05	0.387290	1	0
R3HDML	140902	broad.mit.edu	37	20	42979419	42979419	+	Missense_Mutation	SNP	T	T	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr20:42979419T>G	ENST00000217043.2	+	5	921	c.749T>G	c.(748-750)tTc>tGc	p.F250C	RP5-881L22.5_ENST00000430481.1_RNA|RP5-881L22.5_ENST00000438702.1_RNA	NM_178491.2	NP_848586.1	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like	250						extracellular region	peptidase inhibitor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)	21		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			TCCAACAAGTTCACGTGGTTC	0.522000													18	111					0	0	0.557998	0	0
SLC10A5	347051	broad.mit.edu	37	8	82606469	82606469	+	Missense_Mutation	SNP	G	G	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr8:82606469G>C	ENST00000518568.1	-	1	1940	c.739C>G	c.(739-741)Ctg>Gtg	p.L247V		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	247						integral to membrane	bile acid:sodium symporter activity	p.L247L(1)		autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						ATCATGATCAGAGCCAATAAT	0.418000													35	153					0	0	0.819951	0	0
UNC79	57578	broad.mit.edu	37	14	94004418	94004418	+	Silent	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr14:94004418G>T	ENST00000553484.1	+	12	1360	c.1206G>T	c.(1204-1206)cgG>cgT	p.R402R	UNC79_ENST00000256339.4_Silent_p.R225R|UNC79_ENST00000393151.2_Silent_p.R402R|UNC79_ENST00000555664.1_Silent_p.R402R			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	402						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GGCCTGTTCGGTACTGCAAGA	0.552000													14	50					6.31663e-08	6.90271e-08	0.479597	1	0
ITGA7	3679	broad.mit.edu	37	12	56078890	56078890	+	Silent	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:56078890C>T	ENST00000257879.6	-	25	3581	c.3366G>A	c.(3364-3366)ggG>ggA	p.G1122G	ITGA7_ENST00000257880.7_3'UTR|ITGA7_ENST00000452168.2_Silent_p.G1029G|ITGA7_ENST00000394229.2_3'UTR|ITGA7_ENST00000347027.6_Silent_p.G1116G|ITGA7_ENST00000553804.1_Silent_p.G1126G|ITGA7_ENST00000394230.2_3'UTR|ITGA7_ENST00000555728.1_Silent_p.G1166G	NM_002206.2	NP_002197.2	Q13683	ITA7_HUMAN	integrin, alpha 7	1166					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCTCGGGATGCCCGTCAGCAG	0.682000													3	29					0	0	0.115264	0	0
BCL9L	283149	broad.mit.edu	37	11	118769210	118769210	+	Missense_Mutation	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr11:118769210G>A	ENST00000334801.3	-	8	5378	c.4414C>T	c.(4414-4416)Cac>Tac	p.H1472Y	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1472					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CGAAGGGGGTGGGACACCATG	0.706000													7	43					0	0	0.248553	0	0
MICU2	221154	broad.mit.edu	37	13	22067422	22067422	+	Missense_Mutation	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr13:22067422T>A	ENST00000382374.4	-	12	1336	c.1271A>T	c.(1270-1272)gAa>gTa	p.E424V	MICU2_ENST00000479790.1_5'UTR	NM_152726.2	NP_689939.1			mitochondrial calcium uptake 2																		TTTCCAGACTTCTTTTACTCC	0.313000													14	116					0	0	0.479597	0	0
PROX1	5629	broad.mit.edu	37	1	214170392	214170392	+	Missense_Mutation	SNP	A	A	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:214170392A>T	ENST00000366958.4	+	2	1122	c.514A>T	c.(514-516)Ata>Tta	p.I172L	PROX1_ENST00000435016.1_Missense_Mutation_p.I172L|PROX1_ENST00000261454.4_Missense_Mutation_p.I172L|PROX1_ENST00000498508.2_Missense_Mutation_p.I172L	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	172					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GGTTGAGAATATAATTCGGGG	0.507000													10	92					0	0	0.335167	0	0
EP400	57634	broad.mit.edu	37	12	132554124	132554124	+	Missense_Mutation	SNP	A	A	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:132554124A>G	ENST00000333577.4	+	52	9176	c.9067A>G	c.(9067-9069)Acc>Gcc	p.T3023A	EP400_ENST00000332482.4_Missense_Mutation_p.T2950A|EP400_ENST00000389562.2_Missense_Mutation_p.T2986A|EP400_ENST00000389561.2_Missense_Mutation_p.T2987A|EP400_ENST00000330386.6_Missense_Mutation_p.T2906A			Q96L91	EP400_HUMAN	E1A binding protein p400	3023					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCAGTTTCTTACCACACCCAT	0.652000													21	126					0	0	0.575678	0	0
MARCH11	441061	broad.mit.edu	37	5	16067810	16067810	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr5:16067810C>T	ENST00000332432.8	-	4	1178	c.979G>A	c.(979-981)Gcc>Acc	p.A327T		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	327						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						ATGTCTGTGGCTTTGTCATAA	0.468000													10	54					0	0	0.335167	0	0
NTRK1	4914	broad.mit.edu	37	1	156836721	156836721	+	Missense_Mutation	SNP	C	C	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:156836721C>G	ENST00000368196.3	+	4	499	c.379C>G	c.(379-381)Ctg>Gtg	p.L127V	NTRK1_ENST00000358660.3_Missense_Mutation_p.L127V|NTRK1_ENST00000392302.2_Missense_Mutation_p.L97V|NTRK1_ENST00000524377.1_Missense_Mutation_p.L127V	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	127					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CTTCAACGCTCTGGAGTCTCT	0.592000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			12	112					0	0	0.479597	0	0
PLAC1	10761	broad.mit.edu	37	X	133700599	133700599	+	Silent	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chrX:133700599T>A	ENST00000359237.4	-	3	399	c.114A>T	c.(112-114)acA>acT	p.T38T	PLAC1_ENST00000476971.1_5'UTR	NM_021796.3	NP_068568.1	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1	38					placenta development	extracellular region				large_intestine(4)|lung(1)|pancreas(1)	6	Acute lymphoblastic leukemia(192;0.000127)					AGGGGTGCACTGTGACCATGA	0.512000													77	110					0	0	0.870114	0	0
HSPA4	3308	broad.mit.edu	37	5	132439651	132439651	+	Missense_Mutation	SNP	T	T	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr5:132439651T>C	ENST00000304858.2	+	18	2541	c.2252T>C	c.(2251-2253)cTg>cCg	p.L751P		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	751					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding	p.L751P(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGCTAAATCTGCAGAACAAG	0.358000													33	112					0	0	0.750413	0	0
SULF1	23213	broad.mit.edu	37	8	70501331	70501331	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr8:70501331C>T	ENST00000260128.4	+	8	1406	c.689C>T	c.(688-690)tCa>tTa	p.S230L	SULF1_ENST00000419716.3_Missense_Mutation_p.S230L|SULF1_ENST00000402687.4_Missense_Mutation_p.S230L|SULF1_ENST00000458141.2_Missense_Mutation_p.S230L	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	230					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CCCGAGGACTCAGCCCCACAG	0.493000													16	58					0	0	0.479597	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													4	42					0	0	0.184627	0	0
MYO16	23026	broad.mit.edu	37	13	109792688	109792688	+	Missense_Mutation	SNP	C	C	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr13:109792688C>A	ENST00000356711.2	+	32	4188	c.4062C>A	c.(4060-4062)agC>agA	p.S1354R	MYO16_ENST00000357550.2_Missense_Mutation_p.S1354R	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1354					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCAAGCGCAGCCCCAACACCA	0.692000													12	46					9.05144e-12	1.05434e-11	0.435327	1	0
TRPM6	140803	broad.mit.edu	37	9	77377717	77377717	+	Silent	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr9:77377717C>T	ENST00000451710.3	-	26	4107	c.3870G>A	c.(3868-3870)cgG>cgA	p.R1290R	TRPM6_ENST00000449912.2_Silent_p.R1285R|TRPM6_ENST00000376864.4_Silent_p.R1290R|TRPM6_ENST00000361255.3_Silent_p.R1285R|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000360774.1_Silent_p.R1290R			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1290					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTGGGGGATGCCGGCCTCCAG	0.488000													5	282					0	0	0.184627	0	0
VPS4B	9525	broad.mit.edu	37	18	61064278	61064278	+	Missense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr18:61064278G>T	ENST00000238497.5	-	9	1284	c.1081C>A	c.(1081-1083)Cat>Aat	p.H361N		NM_004869.3	NP_004860.2	O75351	VPS4B_HUMAN	vacuolar protein sorting 4 homolog B (S. cerevisiae)	361					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			breast(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	13						TTTTTAAAATGAGTAGCTGAC	0.403000													27	121					4.7796e-09	5.44772e-09	0.681144	1	0
KRT27	342574	broad.mit.edu	37	17	38938401	38938401	+	Missense_Mutation	SNP	C	C	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr17:38938401C>A	ENST00000301656.3	-	1	385	c.345G>T	c.(343-345)aaG>aaT	p.K115N		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	115	Coil 1A.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				ACCCCTTGATCTTCTGCTCCA	0.498000													31	155					6.04164e-23	7.27743e-23	0.750413	1	0
GPR89A	653519	broad.mit.edu	37	1	145788844	145788844	+	Missense_Mutation	SNP	T	T	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:145788844T>G	ENST00000313835.9	-	9	882	c.739A>C	c.(739-741)Att>Ctt	p.I247L	GPR89A_ENST00000462900.2_Missense_Mutation_p.I222L|GPR89A_ENST00000478703.1_Intron|GPR89A_ENST00000454423.3_Missense_Mutation_p.I127L|GPR89A_ENST00000534502.1_Missense_Mutation_p.I222L			B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A	247					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity			breast(1)|large_intestine(3)|lung(1)|skin(1)	6	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TCCTGTTGAATAAGAGTAAGA	0.388000													24	146					0	0	0.804634	0	0
COL14A1	7373	broad.mit.edu	37	8	121228653	121228653	+	Missense_Mutation	SNP	C	C	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr8:121228653C>A	ENST00000297848.3	+	14	1931	c.1661C>A	c.(1660-1662)aCc>aAc	p.T554N	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.T554N|COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.T459N	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	554	Fibronectin type-III 4.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCTCGATTAACCTGGGACCCA	0.383000													28	131					2.65835e-16	3.13094e-16	0.717897	1	0
MUC16	94025	broad.mit.edu	37	19	9061452	9061452	+	Missense_Mutation	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr19:9061452G>A	ENST00000397910.4	-	3	26197	c.25994C>T	c.(25993-25995)gCt>gTt	p.A8665V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8667	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACTAAGTCAGCCAAAACAGA	0.443000													14	117					0	0	0.435327	0	0
CCPG1	9236	broad.mit.edu	37	15	55652554	55652554	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr15:55652554C>T	ENST00000310958.6	-	8	1715	c.1417G>A	c.(1417-1419)Gga>Aga	p.G473R	DYX1C1-CCPG1_ENST00000565113.1_RNA|CCPG1_ENST00000442196.3_Missense_Mutation_p.G473R|CCPG1_ENST00000425574.3_Intron|CCPG1_ENST00000569205.1_Missense_Mutation_p.G473R	NM_001204450.1|NM_001204451.1|NM_004748.4|NM_020739.3	NP_001191379.1|NP_001191380.1|NP_004739.3|NP_065790.2	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1	473					cell cycle	integral to membrane				autonomic_ganglia(1)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|stomach(3)	30				all cancers(107;0.0354)		CTGTGGCTTCCTCTGCCCCCT	0.398000													108	520					0	0	0.870114	0	0
RLIM	51132	broad.mit.edu	37	X	73811938	73811938	+	Silent	SNP	G	G	C	rs61754468	by1000genomes	TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chrX:73811938G>C	ENST00000332687.6	-	4	1430	c.1212C>G	c.(1210-1212)acC>acG	p.T404T	RLIM_ENST00000349225.2_Silent_p.T404T	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	404					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding	p.T404T(6)		breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GCCTTAACATGGTCTGAATTG	0.413000													4	96					0	0	0.150653	0	0
TBX21	30009	broad.mit.edu	37	17	45822521	45822521	+	Missense_Mutation	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr17:45822521G>A	ENST00000177694.1	+	6	1608	c.1397G>A	c.(1396-1398)cGg>cAg	p.R466Q		NM_013351.1	NP_037483.1	Q9UL17	TBX21_HUMAN	T-box 21	466					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|endometrium(1)|large_intestine(3)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	22						TCAGAGGGACGGGGACCAGAG	0.657000													12	54					0	0	0.387290	0	0
SLC5A12	159963	broad.mit.edu	37	11	26734236	26734236	+	Missense_Mutation	SNP	G	G	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr11:26734236G>C	ENST00000396005.3	-	2	666	c.357C>G	c.(355-357)ttC>ttG	p.F119L	SLC5A12_ENST00000280467.6_Missense_Mutation_p.F119L	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	119					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						CTGGTTTGTTGAATCGTAGTT	0.408000													8	376					0	0	0.278610	0	0
SGOL2	151246	broad.mit.edu	37	2	201434403	201434403	+	Missense_Mutation	SNP	A	A	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr2:201434403A>G	ENST00000357799.4	+	6	589	c.491A>G	c.(490-492)aAt>aGt	p.N164S	SGOL2_ENST00000409203.3_Missense_Mutation_p.N164S	NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	164					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						TTAACTTCAAATGATGATGAA	0.318000													19	78					0	0	0.557998	0	0
RFXAP	5994	broad.mit.edu	37	13	37401839	37401839	+	Missense_Mutation	SNP	T	T	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr13:37401839T>G	ENST00000255476.2	+	3	902	c.768T>G	c.(766-768)aaT>aaG	p.N256K	RFXAP_ENST00000472888.1_3'UTR	NM_000538.3	NP_000529.1	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	256	C-terminal domain.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		AGCTATTAAATCAGCAAGTTT	0.318000													14	60					0	0	0.457914	0	0
HERPUD2	64224	broad.mit.edu	37	7	35678029	35678029	+	Missense_Mutation	SNP	T	T	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr7:35678029T>G	ENST00000396081.1	-	5	1352	c.548A>C	c.(547-549)tAt>tCt	p.Y183S	HERPUD2_ENST00000426180.1_5'UTR|HERPUD2_ENST00000311350.3_Missense_Mutation_p.Y183S	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	183					response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						AAACGCGGGATACACTGGGAA	0.398000													16	88					0	0	0.520397	0	0
ROS1	6098	broad.mit.edu	37	6	117704636	117704636	+	Missense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr6:117704636G>T	ENST00000368508.3	-	16	2538	c.2340C>A	c.(2338-2340)gaC>gaA	p.D780E	ROS1_ENST00000368507.3_Missense_Mutation_p.D775E|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	780					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGGTAACAATGTCTGTGTGTC	0.403000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								48	176					2.9001e-28	3.57454e-28	0.870114	1	0
UBBP4	23666	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													4	85					0.00024832	0.000258058	0.150653	1	0
BDP1	55814	broad.mit.edu	37	5	70798507	70798507	+	Silent	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr5:70798507G>A	ENST00000358731.4	+	15	2393	c.2130G>A	c.(2128-2130)aaG>aaA	p.K710K	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	710					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GATTGCAAAAGCCAAAGCCAA	0.403000													20	70					0	0	0.575678	0	0
TADA1	117143	broad.mit.edu	37	1	166826832	166826832	+	Missense_Mutation	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:166826832G>A	ENST00000367874.4	-	8	1073	c.980C>T	c.(979-981)gCa>gTa	p.A327V	TADA1_ENST00000467021.1_5'UTR	NM_053053.3	NP_444281.1	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1	327					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	11						CTCCTTGGCTGCCAAGCGCTG	0.453000													4	150					0	0	0.150653	0	0
VIM	7431	broad.mit.edu	37	10	17277297	17277297	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr10:17277297C>T	ENST00000544301.1	+	7	1551	c.1138C>T	c.(1138-1140)Ctt>Ttt	p.L380F	VIM_ENST00000224237.5_Missense_Mutation_p.L380F	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	380	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGCTCGTCACCTTCGTGAATA	0.493000													20	86					0	0	0.575678	0	0
LRBA	987	broad.mit.edu	37	4	151656456	151656456	+	Missense_Mutation	SNP	A	A	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr4:151656456A>T	ENST00000535741.1	-	36	6181	c.5708T>A	c.(5707-5709)cTg>cAg	p.L1903Q	LRBA_ENST00000507224.1_Missense_Mutation_p.L1903Q|LRBA_ENST00000510413.1_Missense_Mutation_p.L1903Q|LRBA_ENST00000357115.3_Missense_Mutation_p.L1903Q			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1903						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CTGCCTGCTCAGGATAAATTC	0.363000													55	305					0	0	0.870114	0	0
RGS3	5998	broad.mit.edu	37	9	116356444	116356444	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr9:116356444C>T	ENST00000462403.1	+	1	679	c.245C>T	c.(244-246)gCt>gTt	p.A82V	RGS3_ENST00000342620.5_Intron|RGS3_ENST00000374134.3_Intron|RGS3_ENST00000374140.2_Intron|RGS3_ENST00000394646.3_Intron|RGS3_ENST00000350696.5_Intron|RGS3_ENST00000462143.1_Intron|RGS3_ENST00000343817.5_Intron	NM_144489.2	NP_652760.2	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	0					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GCGTGTGTGGCTGCAGCCTGC	0.667000													29	120					0	0	0.717897	0	0
JAGN1	84522	broad.mit.edu	37	3	9934835	9934835	+	Missense_Mutation	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr3:9934835T>A	ENST00000307768.4	+	2	495	c.326T>A	c.(325-327)cTc>cAc	p.L109H		NM_032492.3	NP_115881.3	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1 (Drosophila)	109						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|lung(3)|ovary(1)	10	Medulloblastoma(99;0.227)					AGCATGGGACTCTTTTCCATC	0.517000													25	96					0	0	0.667858	0	0
SMG1	23049	broad.mit.edu	37	16	18908185	18908185	+	Missense_Mutation	SNP	A	A	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr16:18908185A>T	ENST00000446231.2	-	2	598	c.186T>A	c.(184-186)aaT>aaA	p.N62K	SMG1_ENST00000565224.1_Missense_Mutation_p.N36K|SMG1_ENST00000389467.3_Missense_Mutation_p.N62K			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	62	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						CCACAGCTGAATTTGAAGGTT	0.403000													7	26					0	0	0.248553	0	0
TNC	3371	broad.mit.edu	37	9	117852928	117852928	+	Missense_Mutation	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr9:117852928T>A	ENST00000350763.4	-	2	781	c.370A>T	c.(370-372)Agc>Tgc	p.S124C	TNC_ENST00000535648.1_Missense_Mutation_p.S124C|TNC_ENST00000340094.3_Missense_Mutation_p.S124C|TNC_ENST00000423613.2_Missense_Mutation_p.S124C|TNC_ENST00000345230.3_Missense_Mutation_p.S124C|TNC_ENST00000341037.4_Missense_Mutation_p.S124C|TNC_ENST00000537320.1_Missense_Mutation_p.S124C|TNC_ENST00000542877.1_Missense_Mutation_p.S124C|TNC_ENST00000346706.3_Missense_Mutation_p.S124C	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	124					cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TCCAGTCTGCTCAGCAGCTCC	0.592000													80	352					0	0	0.870114	0	0
BRD9	65980	broad.mit.edu	37	5	864655	864655	+	Silent	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr5:864655C>T	ENST00000323510.4	-	13	1433	c.1434G>A	c.(1432-1434)gaG>gaA	p.E478E	BRD9_ENST00000467963.1_Silent_p.E574E|BRD9_ENST00000483173.1_Silent_p.E521E|BRD9_ENST00000388890.4_Silent_p.E458E			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	574							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			CGTCTGGCTGCTCCCCGACAC	0.562000													12	80					0	0	0.435327	0	0
RPAP3	79657	broad.mit.edu	37	12	48063952	48063952	+	Silent	SNP	T	T	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:48063952T>G	ENST00000005386.3	-	13	1579	c.1464A>C	c.(1462-1464)acA>acC	p.T488T	RPAP3_ENST00000432584.3_Silent_p.T329T|RPAP3_ENST00000380650.4_Silent_p.T454T	NM_024604.2	NP_078880.2	Q9H6T3	RPAP3_HUMAN	RNA polymerase II associated protein 3	488							binding			endometrium(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Lung SC(27;0.192)					GAGTATCACTTGTGGGAAAAA	0.388000													37	190					0	0	0.796494	0	0
IARS2	55699	broad.mit.edu	37	1	220284279	220284279	+	Splice_Site	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:220284279G>T	ENST00000366922.1	+	11	1594	c.1263_splice	c.e11+1	p.K421_splice	IARS2_ENST00000302637.5_Splice_Site_p.K493_splice			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	493					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CTGCAGCCAAGGTATAAAAAG	0.453000													9	83					7.48243e-07	8.09324e-07	0.335167	1	0
DIP2B	57609	broad.mit.edu	37	12	51089695	51089695	+	Missense_Mutation	SNP	A	A	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:51089695A>C	ENST00000301180.5	+	16	1912	c.1878A>C	c.(1876-1878)agA>agC	p.R626S		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	626						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						GGGACCAAAGAGACGTGAGCT	0.423000													63	217					0	0	0.870114	0	0
C11orf16	56673	broad.mit.edu	37	11	8948531	8948531	+	Missense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr11:8948531G>T	ENST00000326053.5	-	4	621	c.515C>A	c.(514-516)cCt>cAt	p.P172H	C11orf16_ENST00000525780.1_Missense_Mutation_p.P172H	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	172										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AACAGTGCCAGGGCCATACTG	0.547000													18	91					2.94398e-08	3.25065e-08	0.557998	1	0
TTN	7273	broad.mit.edu	37	2	179462404	179462404	+	Missense_Mutation	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr2:179462404T>A	ENST00000589042.1	-	294	57629	c.57405A>T	c.(57403-57405)caA>caT	p.Q19135H	TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.Q17494H|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.Q10195H|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.Q10262H|TTN_ENST00000342992.6_Missense_Mutation_p.Q16567H|TTN_ENST00000460472.2_Missense_Mutation_p.Q10070H|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17494	Ig-like 108.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTGGCTTCTTGAGGTAAGG	0.483000													14	75					0	0	0.457914	0	0
TEX11	56159	broad.mit.edu	37	X	69871375	69871375	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chrX:69871375G>A	ENST00000395889.2	-	18	1608	c.1453C>T	c.(1453-1455)Cga>Tga	p.R485*	TEX11_ENST00000374333.2_Nonsense_Mutation_p.R470*|TEX11_ENST00000344304.3_Nonsense_Mutation_p.R485*|TEX11_ENST00000374320.2_Nonsense_Mutation_p.R160*	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	485							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					GGGTCATGTCGTTCAGCTTCT	0.348000													13	38					0	0	0.479597	0	0
GOLGB1	2804	broad.mit.edu	37	3	121415881	121415881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr3:121415881C>T	ENST00000393667.3	-	13	3599	c.3489G>A	c.(3487-3489)tgG>tgA	p.W1163*	GOLGB1_ENST00000340645.5_Nonsense_Mutation_p.W1158*	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1158					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		GTTCTGGTTTCCAGTGTTCAC	0.433000													70	258					0	0	0.870114	0	0
RS1	6247	broad.mit.edu	37	X	18690181	18690181	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chrX:18690181C>T	ENST00000379984.3	-	1	48	c.8G>A	c.(7-9)cGc>cAc	p.R3H		NM_000330.3	NP_000321.1	O15537	XLRS1_HUMAN	retinoschisin 1	3					cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space		p.R3H(1)		cervix(1)|endometrium(4)|large_intestine(5)|lung(2)|ovary(2)|skin(1)	15	Hepatocellular(33;0.183)					TTCTATCTTGCGTGACATCTT	0.428000													4	107					0	0	0.217242	0	0
TBC1D2	55357	broad.mit.edu	37	9	101017592	101017592	+	Translation_Start_Site	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr9:101017592G>T	ENST00000342112.5	-	0	280				TBC1D2_ENST00000375064.1_Missense_Mutation_p.L78M|TBC1D2_ENST00000375066.5_Missense_Mutation_p.L78M			Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2							cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GAGTAATACAGCTGACATTTC	0.547000													24	89					1.96895e-08	2.19693e-08	0.639603	1	0
KLHDC10	23008	broad.mit.edu	37	7	129769357	129769357	+	Missense_Mutation	SNP	G	G	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr7:129769357G>C	ENST00000335420.5	+	9	1194	c.1060G>C	c.(1060-1062)Gtg>Ctg	p.V354L		NM_014997.3	NP_055812.1	Q6PID8	KLD10_HUMAN	kelch domain containing 10	354										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|liver(2)|lung(10)|prostate(1)	17						TTTCCAATGGGTGAAGCTCCC	0.403000													35	146					0	0	0.769981	0	0
ANK3	288	broad.mit.edu	37	10	61874052	61874052	+	Missense_Mutation	SNP	A	A	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr10:61874052A>G	ENST00000280772.1	-	26	3070	c.2879T>C	c.(2878-2880)cTt>cCt	p.L960P	ANK3_ENST00000373827.2_Missense_Mutation_p.L954P|ANK3_ENST00000503366.1_Missense_Mutation_p.L961P|ANK3_ENST00000355288.2_Missense_Mutation_p.L94P	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	960					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTAATGTCTAAGAGAATCTGA	0.348000													17	82					0	0	0.520397	0	0
TDRD1	56165	broad.mit.edu	37	10	115973103	115973103	+	Splice_Site	SNP	A	A	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr10:115973103A>T	ENST00000251864.2	+	15	1984		c.e15-1		TDRD1_ENST00000369280.1_Splice_Site|TDRD1_ENST00000369282.1_Splice_Site|TDRD1_ENST00000369281.2_Splice_Site|TDRD1_ENST00000422662.1_Splice_Site	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1						DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		ATTCTTTGTTAGGAGTAAAGC	0.333000													15	91					0	0	0.457914	0	0
METAP2	10988	broad.mit.edu	37	12	95888731	95888731	+	Splice_Site	SNP	A	A	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:95888731A>T	ENST00000323666.5	+	6	819		c.e6-1		METAP2_ENST00000551840.1_Splice_Site|METAP2_ENST00000550777.1_Splice_Site|METAP2_ENST00000261220.9_Splice_Site|METAP2_ENST00000546753.1_Splice_Site	NM_006838.3	NP_006829.1	P50579	AMPM2_HUMAN	methionyl aminopeptidase 2						N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|large_intestine(2)|lung(7)|prostate(1)	13					L-Methionine(DB00134)	TTTTTGTTTTAGTGAAAAGTT	0.323000													25	72					0	0	0.639603	0	0
MAPK7	5598	broad.mit.edu	37	17	19284327	19284327	+	Missense_Mutation	SNP	C	C	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr17:19284327C>A	ENST00000308406.5	+	4	1191	c.805C>A	c.(805-807)Cac>Aac	p.H269N	MAPK7_ENST00000395602.4_Missense_Mutation_p.H269N|MAPK7_ENST00000571657.1_Intron|MAPK7_ENST00000299612.7_Missense_Mutation_p.H130N|MAPK7_ENST00000395604.3_Missense_Mutation_p.H269N	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	269	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					AAACTATGTACACCAGCTACA	0.562000													11	77					0.000978159	0.00100665	0.387290	1	0
FAM120AOS	158293	broad.mit.edu	37	9	96212845	96212845	+	Silent	SNP	A	A	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr9:96212845A>G	ENST00000375412.5	-	2	1482	c.600T>C	c.(598-600)gcT>gcC	p.A200A	FAM120AOS_ENST00000479094.1_5'UTR|FAM120AOS_ENST00000423591.1_Silent_p.A18A	NM_198841.2	NP_942138.2	Q5T036	F120S_HUMAN	family with sequence similarity 120A opposite strand	200										kidney(1)|large_intestine(1)|lung(3)|skin(1)	6						GTCCGGCCACAGCCTGTCGGT	0.502000													22	66					0	0	0.592651	0	0
RRAGC	64121	broad.mit.edu	37	1	39321416	39321416	+	Missense_Mutation	SNP	T	T	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:39321416T>C	ENST00000373001.3	-	3	781	c.605A>G	c.(604-606)gAc>gGc	p.D202G		NM_022157.2	NP_071440.1	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	202					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)	10	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				ATCTGCAAGGTCATCATTGGC	0.398000													41	236					0	0	0.853193	0	0
SP140	11262	broad.mit.edu	37	2	231150512	231150512	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr2:231150512C>T	ENST00000392045.3	+	17	1724	c.1610C>T	c.(1609-1611)gCg>gTg	p.A537V	SP140_ENST00000420434.3_Missense_Mutation_p.A510V|SP140_ENST00000417495.3_Missense_Mutation_p.A423V|SP140_ENST00000486687.2_Missense_Mutation_p.A461V|SP140_ENST00000350136.5_Missense_Mutation_p.A406V|SP140_ENST00000343805.6_Missense_Mutation_p.A477V	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	537					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAAAAGAAGGCGAACGTGAAT	0.448000													33	167					0	0	0.769981	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													2	4					0	0	0.115264	0	0
GPR142	350383	broad.mit.edu	37	17	72368005	72368005	+	Missense_Mutation	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr17:72368005G>A	ENST00000335666.4	+	4	703	c.655G>A	c.(655-657)Gga>Aga	p.G219R		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	219						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CCTCCTGCAGGGAGCAGTGCT	0.632000													11	38					0	0	0.411799	0	0
DOK4	55715	broad.mit.edu	37	16	57508842	57508842	+	Silent	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr16:57508842C>T	ENST00000566936.1	-	5	759	c.462G>A	c.(460-462)gaG>gaA	p.E154E	DOK4_ENST00000561918.1_5'UTR|DOK4_ENST00000569548.1_Silent_p.E154E|DOK4_ENST00000340099.4_Silent_p.E154E			Q8TEW6	DOK4_HUMAN	docking protein 4	154	IRS-type PTB.						insulin receptor binding			kidney(1)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	6						GCAGCTTGCACTCGCCATACA	0.607000													10	54					0	0	0.361761	0	0
CLASP1	23332	broad.mit.edu	37	2	122363357	122363357	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr2:122363357C>T	ENST00000263710.4	-	2	504	c.115G>A	c.(115-117)Gac>Aac	p.D39N	CLASP1_ENST00000455322.2_Missense_Mutation_p.D39N|CLASP1_ENST00000541377.1_Missense_Mutation_p.D39N|CLASP1_ENST00000409078.3_Missense_Mutation_p.D39N|CLASP1_ENST00000397587.3_Missense_Mutation_p.D39N	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	39					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					TGCTCAAGGTCAGCAGACTTC	0.478000													23	93					0	0	0.608945	0	0
GOLGB1	2804	broad.mit.edu	37	3	121415891	121415891	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr3:121415891C>T	ENST00000393667.3	-	13	3589	c.3479G>A	c.(3478-3480)aGt>aAt	p.S1160N	GOLGB1_ENST00000340645.5_Missense_Mutation_p.S1155N	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1155					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		CCAGTGTTCACTACTACCTGT	0.438000													71	265					0	0	0.870114	0	0
DPEP3	64180	broad.mit.edu	37	16	68009728	68009728	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr16:68009728G>T	ENST00000268793.4	-	10	1855	c.1482C>A	c.(1480-1482)taC>taA	p.Y494*		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	469					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		CTGGAACAAGGTATGGGGAGG	0.602000													5	36					8.12818e-05	8.61588e-05	0.248553	1	0
PPBP	5473	broad.mit.edu	37	4	74853010	74853010	+	Silent	SNP	T	T	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr4:74853010T>C	ENST00000296028.3	-	3	459	c.366A>G	c.(364-366)gcA>gcG	p.A122A		NM_002704.3	NP_002695.1	P02775	CXCL7_HUMAN	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	122					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			breast(1)|central_nervous_system(1)|lung(1)|ovary(2)|skin(2)|stomach(1)|urinary_tract(2)	10	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			ATTCATCACCTGCCAATTTTT	0.408000													3	142					0	0	0.150653	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128742	45128742	+	RNA	SNP	T	T	G	rs34655963	by1000genomes	TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr17:45128742T>G	ENST00000575173.1	-	0	418																											TAATGATTTTTATTATACTTT	0.328000													4	135					0	0	0.150653	0	0
VWC2	375567	broad.mit.edu	37	7	49842426	49842426	+	Silent	SNP	C	C	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr7:49842426C>A	ENST00000340652.3	+	3	1372	c.816C>A	c.(814-816)atC>atA	p.I272I		NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	272	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						GCTGTCCCATCTGCAAAAATG	0.572000													13	59					1.5842e-08	1.78644e-08	0.435327	1	0
REV3L	5980	broad.mit.edu	37	6	111709251	111709251	+	Missense_Mutation	SNP	T	T	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr6:111709251T>A	ENST00000435970.1	-	10	1482	c.666A>T	c.(664-666)aaA>aaT	p.K222N	REV3L_ENST00000358835.3_Missense_Mutation_p.K300N|REV3L_ENST00000368805.1_Missense_Mutation_p.K300N|REV3L_ENST00000368802.3_Missense_Mutation_p.K300N			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	300					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCTTCTGAAATTTTTTTTCAC	0.284000								DNA polymerases (catalytic subunits)					30	125					0	0	0.750413	0	0
MUC2	4583	broad.mit.edu	37	11	1080916	1080916	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr11:1080916C>T	ENST00000441003.2	+	10	1327	c.1300C>T	c.(1300-1302)Ccc>Tcc	p.P434S	MUC2_ENST00000359061.5_Missense_Mutation_p.P434S	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	434	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CGAGCTGGCCCCCTGTGGCTC	0.637000													9	54					0	0	0.387290	0	0
SPTBN1	6711	broad.mit.edu	37	2	54880792	54880792	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr2:54880792C>T	ENST00000333896.5	+	26	5970	c.5585C>T	c.(5584-5586)gCg>gTg	p.A1862V	SPTBN1_ENST00000356805.4_Missense_Mutation_p.A1875V	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1875	Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GCGGCCTATGCGGGTGACAAG	0.657000													4	78					0	0	0.150653	0	0
LRMP	4033	broad.mit.edu	37	12	25232608	25232608	+	Missense_Mutation	SNP	T	T	A	rs147316104		TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:25232608T>A	ENST00000354454.3	+	8	984	c.155T>A	c.(154-156)cTg>cAg	p.L52Q	LRMP_ENST00000547044.1_Missense_Mutation_p.L52Q|LRMP_ENST00000548766.1_Missense_Mutation_p.L52Q	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	108					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					TTAGAAATTCTGAATATGGCT	0.378000													21	109					0	0	0.729181	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348224	89348224	+	Missense_Mutation	SNP	C	C	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr16:89348224C>T	ENST00000301030.4	-	9	5186	c.4726G>A	c.(4726-4728)Ggc>Agc	p.G1576S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.G1576S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1576	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ATCAGGTCGCCGTCCCCCAGG	0.587000													13	63					0	0	0.411799	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													3	135					0	0	0.115264	0	0
PGR	5241	broad.mit.edu	37	11	100909954	100909954	+	Missense_Mutation	SNP	G	G	A			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr11:100909954G>A	ENST00000325455.5	-	8	4148	c.2695C>T	c.(2695-2697)Cgg>Tgg	p.R899W	PGR_ENST00000263463.5_Missense_Mutation_p.R797W|PGR_ENST00000534013.1_Missense_Mutation_p.R305W	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	899	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CTCAGTGCCCGGGACTGGATA	0.358000													22	94					0	0	0.592651	0	0
UROD	7389	broad.mit.edu	37	1	45480162	45480162	+	Missense_Mutation	SNP	A	A	G			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:45480162A>G	ENST00000246337.4	+	7	807	c.688A>G	c.(688-690)Aac>Gac	p.N230D	UROD_ENST00000494399.1_3'UTR	NM_000374.4	NP_000365.3	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	230						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4	Acute lymphoblastic leukemia(166;0.155)					ACAGCTCTTCAACAAGTTTGC	0.517000									Porphyria Cutanea Tarda, Type II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	115					0	0	0.779181	0	0
C1orf227	149643	broad.mit.edu	37	1	213009452	213009453	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr1:213009452_213009453insT	ENST00000332912.3	-	2	146_147	c.39_40insA	c.(37-42)aaatggfs	p.W14fs		NM_001024601.2	NP_001019772.1	Q537H7	CA227_HUMAN	chromosome 1 open reading frame 227	14										kidney(1)|large_intestine(1)|lung(1)	3						CTTACTCCATGTTTTTTCATTA	0.366													44	225	---	---	---	---					
RGPD3	653489	broad.mit.edu	37	2	107041102	107041102	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr2:107041102delT	ENST00000409886.3	-	20	3408	c.3321delA	c.(3319-3321)aafs	p.K1107fs	RGPD3_ENST00000304514.7_Frame_Shift_Del_p.K1107fs	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1107	RanBD1 1.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TAGCACACACTTTTAGTACTT	0.423													9	716	---	---	---	---					
BAP1	8314	broad.mit.edu	37	3	52439196	52439196	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr3:52439196delT	ENST00000460680.1	-	11	1517	c.1046delA	c.(1045-1047)acfs	p.N349fs	BAP1_ENST00000296288.5_Frame_Shift_Del_p.N331fs	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	349					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.V335fs*10(1)		NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GGGAGTGGGGTTGGGGTGAAC	0.592			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							41	143	---	---	---	---					
ZBTB11	27107	broad.mit.edu	37	3	101378845	101378846	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr3:101378845_101378846delCA	ENST00000312938.4	-	6	2407_2408	c.1827_1828delTG	c.(1825-1830)agccfs	p.SA609fs		NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CGCAAAGAGGCACTGTACTGAA	0.361													20	127	---	---	---	---					
KLHL24	54800	broad.mit.edu	37	3	183381405	183381407	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr3:183381405_183381407delTCT	ENST00000454652.1	+	5	1466_1468	c.1080_1082delTCT	c.(1078-1083)gca>gc	p.AL360del	KLHL24_ENST00000476808.1_In_Frame_Del_p.AL360del|KLHL24_ENST00000242810.6_In_Frame_Del_p.AL360del			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	360						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CAGTCTGTGCTCTAAGGAATGAC	0.350													31	106	---	---	---	---					
CXXC4	80319	broad.mit.edu	37	4	105412438	105412439	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr4:105412438_105412439insTT	ENST00000394767.2	-	2	971_972	c.521_522insAA	c.(520-522)agafs	p.R174fs	CXXC4_ENST00000426831.1_Frame_Shift_Ins_p.R5fs|CXXC4_ENST00000466963.1_Intron|AC004053.1_ENST00000500179.1_RNA	NM_025212.2	NP_079488.2	Q9H2H0	CXXC4_HUMAN	CXXC finger protein 4	5					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TCTGGGAGTCGTTTCGGTGGTG	0.673													22	114	---	---	---	---					
SLC6A19	340024	broad.mit.edu	37	5	1214127	1214129	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr5:1214127_1214129delCTT	ENST00000304460.10	+	6	890_892	c.834_836delCTT	c.(832-837)tcc>tc	p.SF278del		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	278					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCTTCTTCTCCTTCTCCCTGGCC	0.640													23	149	---	---	---	---					
RP11-368M16.3	0	broad.mit.edu	37	7	57698565	57698566	+	RNA	INS	-	-	TGGG			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr7:57698565_57698566insTGGG	ENST00000605139.1	-	0	416																											CACAGGAGACCTGGGCTGCAGG	0.584													3	4	---	---	---	---					
LOC403323	403323	broad.mit.edu	37	9	66545695	66545695	+	RNA	DEL	A	A	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr9:66545695delA	ENST00000445604.2	-	0	669																											CTGTAAGAGGAAAAAAAAACA	0.373													4	8	---	---	---	---					
ABCC8	6833	broad.mit.edu	37	11	17474797	17474797	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr11:17474797delG	ENST00000302539.4	-	7	1170	c.1045delC	c.(1045-1047)aafs	p.Q349fs	ABCC8_ENST00000389817.3_Frame_Shift_Del_p.Q349fs	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	349	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGGAACTCTTGGGATGAGACA	0.468													24	100	---	---	---	---					
CACNA1C	775	broad.mit.edu	37	12	2706417	2706417	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:2706417delG	ENST00000399655.1	+	21	3080	c.2815delG	c.(2815-2817)ttfs	p.V939fs	CACNA1C_ENST00000399597.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000480911.1_Intron|CACNA1C_ENST00000327702.7_Intron|CACNA1C_ENST00000344100.3_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000399649.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399617.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399644.1_Intron|CACNA1C_ENST00000399629.1_Intron|CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000399634.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000406454.3_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399595.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399603.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000402845.3_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000335762.5_Frame_Shift_Del_p.V964fs|CACNA1C_ENST00000399606.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399621.1_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399601.1_Intron|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000347598.4_Frame_Shift_Del_p.V939fs|CACNA1C_ENST00000399638.1_Frame_Shift_Del_p.V939fs	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	939					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TTTTGATATTGTTTTTACCAC	0.493													31	208	---	---	---	---					
LINC00987	100499405	broad.mit.edu	37	12	9392739	9392740	+	RNA	INS	-	-	TCTTCCTCCTCC	rs71045240		TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr12:9392739_9392740insTCTTCCTCCTCC	ENST00000427111.3	+	0	141_142					NR_036466.1																						caccatcaccttcttcctcccc	0.545													5	3	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25417973	25417973	+	RNA	DEL	C	C	-			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr15:25417973delC	ENST00000549301.1	+	0	503				SNHG14_ENST00000553149.1_RNA																							ATCCCTGTCTCTGCACTTGTC	0.602													8	49	---	---	---	---					
RP4-734C18.1	0	broad.mit.edu	37	20	11256440	11256441	+	RNA	INS	-	-	CTTTCTTG			TCGA-CJ-4869-01A-02D-1429-08	TCGA-CJ-4869-11A-01D-1429-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	43d9e0a3-a4c7-4ee3-a8a9-cea569ebb219	1dc07306-c09f-4d8e-884c-d016908fd841	g.chr20:11256440_11256441insCTTTCTTG	ENST00000444792.1	-	0	303																											tccctcccttcctttctttctt	0.475													3	6	---	---	---	---