Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	NormalRefReads_WU	NormalVarReads_WU	NormalVAF_WU	TumorRefReads_WU	TumorVarReads_WU	TumorVAF_WU	RNARefReads_WU	RNAVarReads_WU	RNAVAF_WU
DNMT3A	0	genome.wustl.edu	36	2	25310746	25310746	+	Missense_Mutation	SNP	C	C	T			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	2	25310746	25310746	C	T	SNP	DNMT3A	NM_022552.3	human	genbank	54_36p	-1	reviewed	missense	c.2645	p.R882H	1.000	superfamily_S-adenosyl-L-methionine-dependent methyltransferases	HMMPfam_PWWP,HMMSmart_SM00293,HMMPfam_DNA_methylase,superfamily_FYVE/PHD zinc finger,PatternScan_C5_MTASE_1,superfamily_S-adenosyl-L-methionine-dependent methyltransferases,superfamily_Tudor/PWWP/MBT	-	no_errors	149	20	11.83	89	80	47.34	21	27	55.10
FAM176A	0	genome.wustl.edu	36	2	75574230	75574230	+	Silent	SNP	T	T	C			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	T	T	T	C	T	T	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	2	75574230	75574230	T	C	SNP	FAM176A	NM_032181.1	human	genbank	54_36p	-1	validated	silent	c.99	p.R33	0.991	NULL	NULL	-	no_errors	122	16	11.51	141	109	42.75	NA	NA	NA
IDH1	0	genome.wustl.edu	36	2	208821358	208821358	+	Missense_Mutation	SNP	G	G	A	rs121913499		TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	2	208821358	208821358	G	A	SNP	IDH1	NM_005896.2	human	genbank	54_36p	-1	reviewed	missense	c.394	p.R132C	1.000	HMMPfam_Iso_dh,superfamily_Isocitrate/Isopropylmalate dehydrogenase-like	HMMPfam_Iso_dh,PatternScan_IDH_IMDH,superfamily_Isocitrate/Isopropylmalate dehydrogenase-like	-	no_errors	67	12	15.00	63	57	47.11	73	80	52.29
FN1	0	genome.wustl.edu	36	2	215946317	215946317	+	Nonsense_Mutation	SNP	C	C	A			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	C	C	C	A	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	2	215946317	215946317	C	A	SNP	FN1	NM_212482.2	human	genbank	54_36p	-1	reviewed	nonsense	c.6220	p.E2074*	1.000	HMMSmart_SM00060,superfamily_Fibronectin type III	HMMPfam_fn1,HMMSmart_SM00058,PatternScan_FN1_1,HMMPfam_fn2,HMMSmart_SM00059,PatternScan_FN2_1,HMMPfam_fn3,HMMSmart_SM00060,superfamily_Fibronectin type III,PatternScan_EGF_1,superfamily_Kringle-like,PatternScan_ALDEHYDE_DEHYDR_GLU,superfamily_Fibronectin type I module	-	no_errors	432	54	11.02	143	101	40.89	1	1	50.00
ZMYND10	0	genome.wustl.edu	36	3	50355818	50355818	+	Missense_Mutation	SNP	A	A	C			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	A	A	A	C	A	A	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	3	50355818	50355818	A	C	SNP	ZMYND10	NM_015896.2	human	genbank	54_36p	-1	validated	missense	c.434	p.L145R	1.000	NULL	HMMPfam_zf-MYND,PatternScan_ZF_MYND_1	-	no_errors	123	9	6.82	68	48	40.34	0	2	100.00
HCLS1	0	genome.wustl.edu	36	3	122859868	122859868	+	Missense_Mutation	SNP	A	A	C			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	A	A	A	C	A	A	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	3	122859868	122859868	A	C	SNP	HCLS1	NM_005335.4	human	genbank	54_36p	-1	validated	missense	c.17	p.V6G	1.000	NULL	HMMPfam_SH3_1,HMMSmart_SM00326,superfamily_SH3-domain,HMMPfam_HS1_rep	-	no_errors	376	28	6.86	181	125	40.72	54	27	33.33
MCHR2	0	genome.wustl.edu	36	6	100497679	100497679	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	6	100497679	100497679	G	A	SNP	MCHR2	NM_001040179.1	human	genbank	54_36p	-1	validated	missense	c.454	p.R152W	0.979	HMMPfam_7tm_1,superfamily_SSF81321	HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1,superfamily_SSF81321	-	no_errors	164	16	8.89	82	73	46.79	NA	NA	NA
EGFR	0	genome.wustl.edu	36	7	55240593	55240593	+	Missense_Mutation	SNP	C	C	G			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	C	C	C	G	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	7	55240593	55240593	C	G	SNP	EGFR	NM_005228.3	human	genbank	54_36p	+1	reviewed	missense	c.3422	p.T1141S	0.763	NULL	HMMPfam_Recep_L_domain,HMMPfam_Pkinase_Tyr,HMMSmart_SM00219,HMMSmart_SM00220,HMMPfam_Furin-like,HMMSmart_SM00261,PatternScan_PROTEIN_KINASE_TYR,superfamily_Growth factor receptor domain,superfamily_Protein kinase-like (PK-like),PatternScan_PROTEIN_KINASE_ATP,superfamily_L domain-like	-	no_errors	269	27	9.06	107	64	36.99	NA	NA	NA
RAB11FIP1	0	genome.wustl.edu	36	8	37851570	37851570	+	Missense_Mutation	SNP	C	C	T			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	8	37851570	37851570	C	T	SNP	RAB11FIP1	NM_001002814.1	human	genbank	54_36p	-1	validated	missense	c.1243	p.A415T	0.003	NULL	HMMPfam_C2,HMMSmart_SM00239,superfamily_C2 domain (Calcium/lipid-binding domain CaLB),HMMPfam_RBD-FIP	-	no_errors	502	37	6.81	372	123	24.60	34	18	34.62
MTA2	0	genome.wustl.edu	36	11	62120719	62120719	+	Missense_Mutation	SNP	T	T	C			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	T	T	T	C	T	T	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	11	62120719	62120719	T	C	SNP	MTA2	NM_004739.2	human	genbank	54_36p	-1	reviewed	missense	c.848	p.Y283C	1.000	HMMSmart_SANT,HMMPfam_Myb_DNA-binding	HMMPfam_GATA,HMMSmart_ZnF_GATA,PatternScan_GATA_ZN_FINGER_1,HMMPfam_ELM2,HMMSmart_SANT,HMMPfam_BAH,HMMSmart_BAH,HMMPfam_Myb_DNA-binding,superfamily_SSF57716	-	no_errors	812	70	7.88	136	102	42.50	77	63	45.00
CCDC67	0	genome.wustl.edu	36	11	92767395	92767395	+	Silent	SNP	A	A	G			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	A	A	A	G	A	A	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	11	92767395	92767395	A	G	SNP	CCDC67	NM_181645.3	human	genbank	54_36p	+1	validated	silent	c.1164	p.T388	1.000	NULL	NULL	-	no_errors	121	13	9.70	91	68	42.50	NA	NA	NA
SMAD9	0	genome.wustl.edu	36	13	36344969	36344969	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	13	36344969	36344969	G	A	SNP	SMAD9	NM_005905.1	human	genbank	54_36p	-1	validated	missense	c.496	p.H166Y	1.000	NULL	HMMPfam_MH2,HMMSmart_SM00524,HMMPfam_MH1,HMMSmart_SM00523,superfamily_SMAD/FHA domain,superfamily_SMAD MH1 domain	-	no_errors	510	0	0.00	315	54	14.56	NA	NA	NA
SLCO3A1	0	genome.wustl.edu	36	15	90472624	90472624	+	Missense_Mutation	SNP	C	C	G			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	C	C	C	G	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	15	90472624	90472624	C	G	SNP	SLCO3A1	NM_013272.1	human	genbank	54_36p	+1	validated	missense	c.1413	p.C471W	1.000	HMMPfam_OATP,HMMPfam_Kazal_2,superfamily_MFS general substrate transporter,superfamily_Kazal-type serine protease inhibitors	HMMPfam_OATP,HMMPfam_Kazal_2,superfamily_MFS general substrate transporter,superfamily_Kazal-type serine protease inhibitors	-	no_errors	626	69	9.87	254	218	45.51	32	29	47.54
GPRC5B	0	genome.wustl.edu	36	16	19790845	19790845	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	16	19790845	19790845	G	A	SNP	GPRC5B	NM_016235.1	human	genbank	54_36p	-1	reviewed	missense	c.824	p.T275M	1.000	HMMPfam_7tm_3	HMMPfam_7tm_3,PatternScan_G_PROTEIN_RECEP_F3_1,PatternScan_G_PROTEIN_RECEP_F3_2,PatternScan_G_PROTEIN_RECEP_F3_3	-	no_errors	220	12	5.11	92	82	46.86	NA	NA	NA
RNF213	0	genome.wustl.edu	36	17	75935198	75935198	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	17	75935198	75935198	G	A	SNP	RNF213	NM_020914.3	human	genbank	54_36p	+1	validated	missense	c.2687	p.R896Q	0.996	HMMSmart_SM00382,superfamily_P-loop containing nucleoside triphosphate hydrolases	HMMSmart_SM00184,HMMSmart_SM00382,HMMPfam_zf-C3HC4,superfamily_P-loop containing nucleoside triphosphate hydrolases,superfamily_RING/U-box	-	no_errors	77	10	11.36	45	37	44.58	25	37	59.68
FKBP8	0	genome.wustl.edu	36	19	18513593	18513593	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	19	18513593	18513593	G	A	SNP	FKBP8	NM_012181.3	human	genbank	54_36p	-1	reviewed	missense	c.188	p.A63V	0.000	NULL	HMMPfam_FKBP_C,HMMPfam_TPR_1,superfamily_SSF48452,superfamily_SSF54534	-	no_errors	96	9	8.49	37	24	39.34	43	52	54.17
SLPI	0	genome.wustl.edu	36	20	43315200	43315200	+	Missense_Mutation	SNP	C	C	T			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	20	43315200	43315200	C	T	SNP	SLPI	NM_003064.2	human	genbank	54_36p	-1	reviewed	missense	c.251	p.R84K	0.002	superfamily_Elafin-like	HMMPfam_WAP,HMMSmart_SM00217,superfamily_Elafin-like,PatternScan_4_DISULFIDE_CORE	-	no_errors	229	22	8.76	128	112	46.67	NA	NA	NA
CEBPA	0	genome.wustl.edu	36	19	38484208	38484210	+	In_Frame_Del	DEL	GTC	GTC	-			TCGA-AB-2863-03D-01W-0755-09	TCGA-AB-2863-11D-01W-0755-09	GTC	GTC	GTC	-	GTC	GTC	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	d4ba0ac2-9d98-430b-bb0d-e1bada2d5486	0f0f4ffb-a917-42d4-b1dd-15841726f923	19	38484208	38484210	GTC	-	DEL	CEBPA	NM_004364.3	human	genbank	54_36p	-1	reviewed	in_frame_del	c.953_951	p.T318in_frame_del	0.992:0.993:0.994	HMMSmart_BRLZ,HMMPfam_bZIP_2	HMMSmart_BRLZ,PatternScan_BZIP_BASIC,HMMPfam_bZIP_2	-	no_errors	0	1	3.45	0	7	25.93	0	32	45.71