Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_Position End_Position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_File Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID chromosome_name start stop reference variant type gene_name transcript_name transcript_species transcript_source transcript_version strand transcript_status trv_type c_position amino_acid_change ucsc_cons domain all_domains deletion_substructures transcript_error NormalRefReads_WU NormalVarReads_WU NormalVAF_WU TumorRefReads_WU TumorVarReads_WU TumorVAF_WU RNARefReads_WU RNAVarReads_WU RNAVAF_WU CASZ1 0 genome.wustl.edu 36 1 10638385 10638385 + Missense_Mutation SNP C C T TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 1 10638385 10638385 C T SNP CASZ1 NM_001079843.1 human genbank 54_36p -1 validated missense c.1573 p.G525S 1.000 NULL PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers - no_errors 30 0 0.00 67 45 40.18 NA NA NA SLC6A9 0 genome.wustl.edu 36 1 44241210 44241210 + Missense_Mutation SNP T T A TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 T T T A T T Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 1 44241210 44241210 T A SNP SLC6A9 NM_201649.1 human genbank 54_36p -1 validated missense c.844 p.N282Y 0.955 HMMPfam_SNF HMMPfam_SNF,PatternScan_NA_NEUROTRAN_SYMP_1,PatternScan_NA_NEUROTRAN_SYMP_2 - no_errors 67 0 0.00 68 41 36.61 NA NA NA DNMT3A 0 genome.wustl.edu 36 2 25310746 25310746 + Missense_Mutation SNP C C T TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 2 25310746 25310746 C T SNP DNMT3A NM_022552.3 human genbank 54_36p -1 reviewed missense c.2645 p.R882H 1.000 superfamily_S-adenosyl-L-methionine-dependent methyltransferases HMMPfam_PWWP,HMMSmart_SM00293,HMMPfam_DNA_methylase,superfamily_FYVE/PHD zinc finger,PatternScan_C5_MTASE_1,superfamily_S-adenosyl-L-methionine-dependent methyltransferases,superfamily_Tudor/PWWP/MBT - no_errors 178 5 2.72 63 64 50.00 NA NA NA ATP13A5 0 genome.wustl.edu 36 3 194511175 194511175 + Missense_Mutation SNP G G C TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 G G G C G G Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 3 194511175 194511175 G C SNP ATP13A5 NM_198505.2 human genbank 54_36p -1 provisional missense c.2471 p.A824G 1.000 superfamily_SSF56784,superfamily_SSF81665 HMMPfam_Cation_ATPase_N,HMMPfam_E1-E2_ATPase,PatternScan_ATPASE_E1_E2,superfamily_SSF56784,superfamily_SSF81653,superfamily_SSF81660,superfamily_SSF81665 - no_errors 157 1 0.62 123 102 45.13 NA NA NA PCDHA13 0 genome.wustl.edu 36 5 140244230 140244230 + Silent SNP G G A TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 G G G A G G Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 5 140244230 140244230 G A SNP PCDHA13 NM_018904.2 human genbank 54_36p +1 reviewed silent c.2193 p.A731 0.239 NULL HMMPfam_Cadherin,HMMSmart_SM00112,PatternScan_CADHERIN_1,HMMPfam_Cadherin_2,superfamily_Cadherin-like - no_errors 8 0 0.00 31 26 44.07 NA NA NA PPP2R2B 0 genome.wustl.edu 36 5 145949924 145949924 + Missense_Mutation SNP G G A TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 G G G A G G Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 5 145949924 145949924 G A SNP PPP2R2B NM_181676.1 human genbank 54_36p -1 reviewed missense c.1120 p.R374C 1.000 superfamily_WD40 repeat-like HMMSmart_SM00320,superfamily_WD40 repeat-like,PatternScan_PR55_1,PatternScan_PR55_2,HMMPfam_PP2A_B_N,HMMPfam_PP2A_B_subs_rcg,PatternScan_WD_REPEATS_1 - no_errors 223 0 0.00 171 123 41.14 NA NA NA C6orf118 0 genome.wustl.edu 36 6 165635643 165635643 + Missense_Mutation SNP C C T TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 6 165635643 165635643 C T SNP C6orf118 NM_144980.3 human genbank 54_36p -1 validated missense c.158 p.R53Q 0.017 NULL NULL - no_errors 49 0 0.00 180 63 25.61 NA NA NA ASB4 0 genome.wustl.edu 36 7 94953408 94953408 + Splice_Site SNP T T G TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 T T T G T T Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 7 94953408 94953408 T G SNP ASB4 NM_016116.1 human genbank 54_36p +1 reviewed splice_site c.187+2 e1+2 1.000 - - - no_errors 65 0 0.00 109 71 39.23 NA NA NA PZP 0 genome.wustl.edu 36 12 9202328 9202328 + Silent SNP A A G TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 A A A G A A Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 12 9202328 9202328 A G SNP PZP NM_002864.2 human genbank 54_36p -1 validated silent c.3249 p.N1083 0.998 superfamily_Terpenoid cyclases/Protein prenyltransferases,HMMPfam_A2M_comp HMMPfam_A2M,HMMPfam_A2M_N,superfamily_Terpenoid cyclases/Protein prenyltransferases,HMMPfam_A2M_recep,superfamily_Alpha-macroglobulin receptor domain,PatternScan_TONB_DEPENDENT_REC_1,HMMPfam_A2M_N_2,HMMPfam_A2M_comp,HMMPfam_Thiol-ester_cl,PatternScan_ALPHA_2_MACROGLOBULIN - no_errors 253 8 3.03 242 39 13.83 NA NA NA KRAS 0 genome.wustl.edu 36 12 25271549 25271549 + Missense_Mutation SNP G G T rs104886029 TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 G G G T G G Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 12 25271549 25271549 G T SNP KRAS NM_033360.3 human genbank 54_36p -1 reviewed missense c.176 p.A59E 1.000 HMMSmart_SM00176,HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases HMMSmart_SM00176,HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases - no_errors 83 1 1.16 74 52 40.62 NA NA NA ANKRD33 0 genome.wustl.edu 36 12 50571180 50571180 + Missense_Mutation SNP C C T TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 12 50571180 50571180 C T SNP ANKRD33 NM_182608.1 human genbank 54_36p +1 validated missense c.1183 p.P395S 0.144 NULL HMMPfam_Ank,HMMSmart_SM00248,superfamily_Ankyrin repeat - no_errors 59 1 1.64 67 63 48.46 NA NA NA RPL6 0 genome.wustl.edu 36 12 111330795 111330795 + Missense_Mutation SNP C C T TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 12 111330795 111330795 C T SNP RPL6 NM_000970.3 human genbank 54_36p -1 reviewed missense c.49 p.E17K 0.240 NULL HMMPfam_Ribosomal_L6e,PatternScan_RIBOSOMAL_L6E,HMMPfam_Ribosomal_L6e_N - no_errors 74 1 1.32 35 17 32.08 NA NA NA ENSG00000211894 0 genome.wustl.edu 36 14 105206164 105206164 + Missense_Mutation SNP T T C TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 T T T C T T Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 14 105206164 105206164 T C SNP ENSG00000211894 ENST00000390546 human ensembl 54_36p -1 known missense c.556 p.M186V 0.021 HMMPfam_C1-set,superfamily_SSF48726 PatternScan_IG_MHC,HMMPfam_C1-set,HMMSmart_IGc1,superfamily_SSF48726 - no_start_codon:pseudogene:no_stop_codon:bad_bp_length_for_coding_region 34 0 0.00 43 28 38.89 NA NA NA IDH2 0 genome.wustl.edu 36 15 88432842 88432842 + Missense_Mutation SNP C C T rs121913503 TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 15 88432842 88432842 C T SNP IDH2 NM_002168.2 human genbank 54_36p -1 reviewed missense c.515 p.R172K 1.000 HMMPfam_Iso_dh,superfamily_Isocitrate/Isopropylmalate dehydrogenase-like HMMPfam_Iso_dh,PatternScan_IDH_IMDH,superfamily_Isocitrate/Isopropylmalate dehydrogenase-like - no_errors 65 0 0.00 75 46 38.02 NA NA NA LOC401875 0 genome.wustl.edu 36 17 20457554 20457554 + RNA SNP C C T TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 17 20457554 20457554 C T SNP LOC401875 XR_042367.1 human genbank 54_36p +1 model rna NULL NULL 0.961 - - - pseudogene 33 0 0.00 98 64 39.51 NA NA NA SMURF2 0 genome.wustl.edu 36 17 60020040 60020040 + Missense_Mutation SNP T T C TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 T T T C T T Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 17 60020040 60020040 T C SNP SMURF2 NM_022739.3 human genbank 54_36p -1 validated missense c.314 p.N105S 1.000 HMMSmart_C2,superfamily_C2_CaLB HMMPfam_C2,HMMSmart_C2,HMMPfam_HECT,HMMSmart_HECTc,superfamily_HECT,HMMPfam_WW,HMMSmart_WW,PatternScan_WW_DOMAIN_1,superfamily_WW_Rsp5_WWP,superfamily_C2_CaLB - no_errors 352 13 3.55 65 47 41.96 NA NA NA CENPB 0 genome.wustl.edu 36 20 3714879 3714879 + Nonsense_Mutation SNP C C T TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 C C C T C C Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 20 3714879 3714879 C T SNP CENPB NM_001810.5 human genbank 54_36p -1 reviewed nonsense c.252 p.W84* 1.000 HMMSmart_CENPB,superfamily_Homeodomain_like,HMMPfam_CenpB-DNA-bind HMMPfam_DDE,HMMSmart_CENPB,HMMPfam_CENP-B_N,superfamily_Homeodomain_like,HMMPfam_Cenp-B_dimeris,HMMPfam_CenpB-DNA-bind,superfamily_SSF101160 - no_errors 11 0 0.00 40 23 35.94 NA NA NA ASXL1 0 genome.wustl.edu 36 20 30486932 30486933 + Frame_Shift_Ins INS - - ACCA TCGA-AB-2864-03D-01W-0755-09 TCGA-AB-2864-11D-01W-0755-09 - - - ACCA - - Verified Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq 1 dbGAP Illumina HiSeq 07f07406-597d-40b7-b218-ef40aad6f0bc d1360466-cb4c-4fea-9ac9-f029dc199e94 20 30486932 30486933 - ACCA INS ASXL1 NM_015338.4 human genbank 54_36p +1 reviewed frame_shift_ins c.2756_2757 p.S921fs 0.000:0.000 NULL NULL - no_errors NA NA NA NA NA NA NA NA NA