Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOC440563	440563	broad.mit.edu	37	1	13183170	13183170	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:13183170G>C	uc010obg.1	-	1	798	c.703C>G	c.(703-705)CAT>GAT	p.H235D		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	235						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						ATCTTTACATGAGTCTCATCT	0.468			NA											23	244					0	0	0.012319	0	0
GNL2	29889	broad.mit.edu	37	1	38048524	38048524	+	Nonsense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:38048524G>C	uc001cbk.2	-	7	813	c.650C>G	c.(649-651)TCA>TGA	p.S217*	GNL2_uc010oif.1_Nonsense_Mutation_p.S58*	NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	217					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				TACAACATCTGATGAATCTAT	0.373			NA											8	120					0	0	0.00308	0	0
FHL3	2275	broad.mit.edu	37	1	38463709	38463709	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:38463709G>A	uc001ccj.2	-	4	514	c.427C>T	c.(427-429)CCC>TCC	p.P143S	FHL3_uc001cck.2_Missense_Mutation_p.P143S|FHL3_uc001ccl.2_Missense_Mutation_p.P143S|FHL3_uc001ccm.2_Missense_Mutation_p.P35S|FHL3_uc009vvl.1_Missense_Mutation_p.P143S	NM_004468	NP_004459	Q13643	FHL3_HUMAN	four and a half LIM domains 3	143	LIM zinc-binding 2.				muscle organ development		zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CCCTTGTCGGGCACAAAAGAA	0.622			NA											5	195					0	0	0.001168	0	0
RLF	6018	broad.mit.edu	37	1	40701980	40701980	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:40701980A>G	uc001cfc.3	+	8	1637	c.1606A>G	c.(1606-1608)AGA>GGA	p.R536G	RLF_uc001cfd.3_Missense_Mutation_p.R227G	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	536					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TAAGGAGAAAAGAGACAAAAA	0.358			NA											3	138					0	0	0.004672	0	0
FOXJ3	22887	broad.mit.edu	37	1	42744180	42744180	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:42744180C>G	uc001che.2	-	5	520	c.208G>C	c.(208-210)GAA>CAA	p.E70Q	FOXJ3_uc001chf.2_Missense_Mutation_p.E70Q|FOXJ3_uc001chg.2_Missense_Mutation_p.E70Q|FOXJ3_uc001chh.1_Missense_Mutation_p.E70Q	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	70					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TGTTGGACTTCTTCCTGGTCC	0.403			NA											20	308					0	0	0.012319	0	0
LEPRE1	64175	broad.mit.edu	37	1	43215957	43215957	+	Silent	SNP	G	G	A	rs140334418		TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:43215957G>A	uc001chv.2	-	11	1733	c.1620C>T	c.(1618-1620)AAC>AAT	p.N540N	LEPRE1_uc001chw.2_Silent_p.N540N|LEPRE1_uc001chx.3_Silent_p.N540N	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	540					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCTCCGTCACGTTGTAGTACA	0.537			NA											4	44					0	0	0.000602	0	0
ZNF691	51058	broad.mit.edu	37	1	43316857	43316857	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:43316857G>T	uc001cih.2	+	2	360	c.309G>T	c.(307-309)AGG>AGT	p.R103S	ZNF691_uc001cig.2_Missense_Mutation_p.R76S|ZNF691_uc009vwm.2_Missense_Mutation_p.R96S	NM_015911	NP_056995	Q5VV52	ZN691_HUMAN	zinc finger protein 691	107						nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCATCCAAGGCATGAGGCAG	0.512			NA											11	350					3.07112e-06	3.35031e-06	0.010729	1	0
CPT2	1376	broad.mit.edu	37	1	53676597	53676597	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:53676597C>T	uc001cvb.3	+	4	1766	c.1251C>T	c.(1249-1251)TTC>TTT	p.F417F		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	417	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)	AACTCAACTTCGAGCTGACTG	0.483			NA											5	59					0	0	0.001984	0	0
LPHN2	23266	broad.mit.edu	37	1	82456080	82456080	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:82456080T>C	uc001dit.3	+	21	3644	c.3463T>C	c.(3463-3465)TCA>CCA	p.S1155P	LPHN2_uc001dis.2_Missense_Mutation_p.S135P|LPHN2_uc001diu.2_Missense_Mutation_p.S1155P|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_Silent_p.I1122I|LPHN2_uc001diw.2_Missense_Mutation_p.S782P	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1211	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTCAGGACATTCACTGAACAA	0.403			NA											13	224					0	0	0.00499	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94639514	94639514	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:94639514G>C	uc001dqj.3	-	23	4066	c.3697C>G	c.(3697-3699)CCT>GCT	p.P1233A	ARHGAP29_uc009wdq.1_Intron	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	1233					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTCACATCAGGCAAGCCAAGC	0.473			NA											14	214					0	0	0.004007	0	0
COL11A1	1301	broad.mit.edu	37	1	103348790	103348790	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:103348790C>T	uc001dul.2	-	64	5254	c.4936G>A	c.(4936-4938)GAG>AAG	p.E1646K	COL11A1_uc001duk.2_Missense_Mutation_p.E842K|COL11A1_uc001dum.2_Missense_Mutation_p.E1658K|COL11A1_uc001dun.2_Missense_Mutation_p.E1607K|COL11A1_uc009weh.2_Missense_Mutation_p.E1530K	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1646	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATGCAAGTCTCACCACCAGAT	0.378			NA											4	125					0	0	0.009096	0	0
WDR47	22911	broad.mit.edu	37	1	109525326	109525326	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:109525326C>G	uc001dwj.2	-	12	2547	c.2171G>C	c.(2170-2172)GGA>GCA	p.G724A	WDR47_uc001dwl.2_Missense_Mutation_p.G732A|WDR47_uc001dwi.2_Missense_Mutation_p.G725A|WDR47_uc010ovf.1_Missense_Mutation_p.G649A	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	724	WD 3.									ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		TAAAATAGCTCCTCCGCTTTC	0.413			NA											7	198					0	0	0.004482	0	0
CD53	963	broad.mit.edu	37	1	111434033	111434033	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:111434033G>A	uc001dzw.2	+	3	174	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CD53_uc001dzx.2_Missense_Mutation_p.M1I|CD53_uc010owa.1_Missense_Mutation_p.M1I|CD53_uc001dzy.2_Missense_Mutation_p.M1I	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	1	Cytoplasmic (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		ATCACGGCATGGGCATGAGTA	0.428			NA											7	123					0	0	0.004482	0	0
HIPK1	204851	broad.mit.edu	37	1	114483059	114483059	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:114483059C>G	uc001eem.2	+	2	215	c.54C>G	c.(52-54)TTC>TTG	p.F18L	HIPK1_uc001eel.2_Missense_Mutation_p.F18L|HIPK1_uc001een.2_Missense_Mutation_p.F18L	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGAGTGCCTTCTGCAGTGCGA	0.463			NA											30	506					0	0	0.007291	0	0
CSDE1	7812	broad.mit.edu	37	1	115273174	115273174	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:115273174C>T	uc001efk.2	-	11	1612	c.1146G>A	c.(1144-1146)GGG>GGA	p.G382G	CSDE1_uc001efi.2_Silent_p.G428G|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Silent_p.G351G|CSDE1_uc001efm.2_Silent_p.G397G|CSDE1_uc009wgv.2_Silent_p.G382G|CSDE1_uc001efn.2_Silent_p.G351G	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	382	CSD 5.			IKCVDRDVRMFFHFSEILDGNQL -> HPSVWIRECSVCSF PLPVKFWMGTSS (in Ref. 2; AAD27787).	male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAGCTGGTTCCCATCCAGAA	0.418			NA											8	125					0	0	0.00308	0	0
INTS3	65123	broad.mit.edu	37	1	153745528	153745528	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:153745528G>A	uc009wom.2	+	30	3243	c.3022G>A	c.(3022-3024)GAA>AAA	p.E1008K	INTS3_uc001fct.2_Missense_Mutation_p.E1008K|INTS3_uc001fcu.2_Missense_Mutation_p.E700K|INTS3_uc001fcv.2_Missense_Mutation_p.E802K|INTS3_uc010peb.1_Missense_Mutation_p.E868K|INTS3_uc001fcw.2_Missense_Mutation_p.E521K|INTS3_uc010pec.1_Missense_Mutation_p.E521K|INTS3_uc001fcy.2_Missense_Mutation_p.E371K|INTS3_uc001fcx.2_Missense_Mutation_p.E305K	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	1009					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCCCAATGCCGAAGAAGAGTC	0.607			NA											36	261					0	0	0.003271	0	0
ADAM15	8751	broad.mit.edu	37	1	155029447	155029447	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:155029447C>T	uc001fgr.1	+	11	1119	c.1018C>T	c.(1018-1020)CTG>TTG	p.L340L	ADAM15_uc001fgq.1_Silent_p.L25L|ADAM15_uc010pet.1_Silent_p.L324L|ADAM15_uc010peu.1_Silent_p.L357L|ADAM15_uc001fgt.1_Silent_p.L340L|ADAM15_uc010pev.1_Silent_p.L350L|ADAM15_uc001fgs.1_Silent_p.L340L|ADAM15_uc001fgu.1_Silent_p.L340L|ADAM15_uc001fgw.1_Silent_p.L340L|ADAM15_uc001fgv.1_Silent_p.L340L|ADAM15_uc001fgx.1_Silent_p.L340L|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	340	Peptidase M12B.|Extracellular (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CACCAGCATCCTGGGAGTCGC	0.627			NA											15	126					0	0	0.003163	0	0
GBA	2629	broad.mit.edu	37	1	155207965	155207965	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:155207965C>T	uc001fjh.2	-	6	871	c.721G>A	c.(721-723)GGA>AGA	p.G241R	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Missense_Mutation_p.G128R|GBA_uc010pfx.1_Missense_Mutation_p.G192R|GBA_uc001fji.2_Missense_Mutation_p.G241R|GBA_uc001fjj.2_Missense_Mutation_p.G241R|GBA_uc001fjk.2_Missense_Mutation_p.G241R|GBA_uc001fjl.2_Missense_Mutation_p.G241R|GBA_uc010pfy.1_Missense_Mutation_p.G154R|GBA_uc009wqk.1_Missense_Mutation_p.G154R	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	241			G -> E (in GD).|G -> R (in GD; type 1 and type 2; gene conversion).		carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	TAGATGTCTCCGGGCTGTCCC	0.567			NA							Gaucher_disease_type_I				8	86					0	0	0.004482	0	0
SPTA1	6708	broad.mit.edu	37	1	158587342	158587342	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:158587342C>A	uc001fst.1	-	47	6784	c.6585G>T	c.(6583-6585)CAG>CAT	p.Q2195H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2195	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTGCTTCCAGCTGAGATTCCA	0.343			NA											6	48					0.000157383	0.000169974	0.00308	1	0
CRP	1401	broad.mit.edu	37	1	159683874	159683874	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:159683874G>A	uc001ftw.2	-	2	220	c.116C>T	c.(115-117)TCC>TTC	p.S39F	CRP_uc001ftx.1_Missense_Mutation_p.S39F|CRP_uc001fty.1_5'Flank	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	39	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TGCTTTGAGGGATACATAGGA	0.473			NA											8	174					0	0	0.006214	0	0
SH2D1B	117157	broad.mit.edu	37	1	162381712	162381712	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:162381712T>C	uc001gbz.1	-	1	217	c.95A>G	c.(94-96)GAC>GGC	p.D32G	SH2D1B_uc001gca.1_Missense_Mutation_p.D32G	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	32	SH2.									pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CGACTCGCTGTCTCTTAAAAG	0.507			NA											10	69					0	0	0.006214	0	0
BAT2L2	23215	broad.mit.edu	37	1	171511180	171511180	+	Silent	SNP	A	A	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:171511180A>G	uc010pmg.1	+	16	4835	c.4569A>G	c.(4567-4569)ACA>ACG	p.T1523T	BAT2L2_uc010pmh.1_Silent_p.T500T	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1523							protein C-terminus binding				0						ATGCACAAACAGTTGTAAAGG	0.413			NA											8	78					0	0	0.006214	0	0
LAMC2	3918	broad.mit.edu	37	1	183208591	183208591	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:183208591G>C	uc001gqa.2	+	20	3276	c.2962G>C	c.(2962-2964)GAC>CAC	p.D988H	LAMC2_uc001gpz.3_Missense_Mutation_p.D988H|LAMC2_uc010poa.1_Missense_Mutation_p.D688H	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	988	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						AGATGCCAGTGACAAGACCCA	0.537			NA											33	264					0	0	0.012213	0	0
KIF21B	23046	broad.mit.edu	37	1	200972738	200972738	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:200972738C>T	uc001gvs.1	-	8	1505	c.1188G>A	c.(1186-1188)CAG>CAA	p.Q396Q	KIF21B_uc001gvr.1_Silent_p.Q396Q|KIF21B_uc009wzl.1_Silent_p.Q396Q|KIF21B_uc010ppn.1_Silent_p.Q396Q|KIF21B_uc001gvt.1_Silent_p.Q254Q	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	396	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TCAGCTCCATCTGCAGCCGAG	0.577			NA											15	100					0	0	0.003163	0	0
PTPN14	5784	broad.mit.edu	37	1	214568247	214568247	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:214568247G>A	uc001hkk.1	-	9	1112	c.841C>T	c.(841-843)CAC>TAC	p.H281Y	PTPN14_uc010pty.1_Missense_Mutation_p.H182Y	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	281	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CTTACCGTGTGAAAGAGGGCA	0.448	Colon(92;557 1424 24372 34121 40073)		NA											8	190					0	0	0.00308	0	0
PTPN14	5784	broad.mit.edu	37	1	214568286	214568286	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:214568286G>A	uc001hkk.1	-	9	1073	c.802C>T	c.(802-804)CTA>TTA	p.L268L	PTPN14_uc010pty.1_Silent_p.L169L	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	268	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		AGCTCCACTAGAATGGTCGAC	0.428	Colon(92;557 1424 24372 34121 40073)		NA											12	234					0	0	0.001855	0	0
WDR64	128025	broad.mit.edu	37	1	241958535	241958535	+	Silent	SNP	C	C	T	rs150522021		TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr1:241958535C>T	uc001hzf.1	+	15	1806	c.1653C>T	c.(1651-1653)TTC>TTT	p.F551F	WDR64_uc001hzg.1_Silent_p.F464F	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	998										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TGGAAGGTTTCGTGACTGAAA	0.383			NA											4	160					0	0	0.001984	0	0
NCOA4	8031	broad.mit.edu	37	10	51585290	51585290	+	Silent	SNP	T	T	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:51585290T>C	uc001jis.3	+	8	1592	c.1389T>C	c.(1387-1389)CCT>CCC	p.P463P	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Silent_p.P479P|NCOA4_uc010qhd.1_Silent_p.P479P|NCOA4_uc010qhe.1_Silent_p.P363P|NCOA4_uc010qhf.1_Silent_p.P297P|NCOA4_uc001jit.2_Silent_p.P463P|NCOA4_uc009xoo.2_Silent_p.P463P	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	463					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						GGCTCTGTCCTAGAAAAGAAG	0.428			NA	T	RET	papillary thyroid 								3	260					0	0	0.004672	0	0
TTC18	118491	broad.mit.edu	37	10	75082846	75082846	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:75082846C>A	uc009xrc.2	-	10	1118	c.997G>T	c.(997-999)GAA>TAA	p.E333*	TTC18_uc001jty.2_Nonsense_Mutation_p.E333*|TTC18_uc009xrd.1_Nonsense_Mutation_p.E141*	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	333							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					AGCTGAGCTTCTTCATCAGTC	0.289			NA											4	125					0.00909568	0.00972607	0.009096	1	0
CYP26C1	340665	broad.mit.edu	37	10	94828109	94828109	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:94828109G>A	uc010qns.1	+	6	1224	c.1224G>A	c.(1222-1224)ATG>ATA	p.M408I	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	408					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				GGAGCGTGATGTATAGCATCC	0.662			NA											12	108					0	0	0.010729	0	0
COL17A1	1308	broad.mit.edu	37	10	105796299	105796299	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:105796299C>T	uc001kxr.2	-	48	3538	c.3369G>A	c.(3367-3369)CTG>CTA	p.L1123L		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1123	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGTCCAAAGACAGGAGGGACC	0.597			NA											12	42					0	0	0.001855	0	0
C10orf79	80217	broad.mit.edu	37	10	105926410	105926410	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:105926410C>T	uc001kxw.2	-	23	2991	c.2875G>A	c.(2875-2877)GAT>AAT	p.D959N	C10orf79_uc009xxq.2_Missense_Mutation_p.D267N	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	959											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TCTTCTTCATCATCCTCTTCA	0.398			NA											10	229					0	0	0.008291	0	0
SHOC2	8036	broad.mit.edu	37	10	112724821	112724821	+	Splice_Site	SNP	T	T	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:112724821T>A	uc001kzl.3	+	2	1052	c.703_splice	c.e2+2	p.G235_splice	SHOC2_uc009xxx.2_Splice_Site_p.G235_splice|SHOC2_uc010qrg.1_Intron|SHOC2_uc001kzn.2_Splice_Site_p.G235_splice	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog						fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		CTGAAATTGGTAAGAGGCCTT	0.328			NA											20	28					0	0	0.008871	0	0
SHOC2	8036	broad.mit.edu	37	10	112764399	112764399	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:112764399G>C	uc001kzl.3	+	5	1357	c.1008G>C	c.(1006-1008)TTG>TTC	p.L336F	SHOC2_uc009xxx.2_Missense_Mutation_p.L336F|SHOC2_uc010qrg.1_5'UTR|SHOC2_uc001kzn.2_Missense_Mutation_p.L290F	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	336	LRR 11.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		TGAATAGTTTGACCTTAGCTA	0.338			NA											4	70					0	0	0.009096	0	0
GLRX3	10539	broad.mit.edu	37	10	131973145	131973145	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:131973145C>T	uc001lkm.1	+	9	861	c.839C>T	c.(838-840)ACA>ATA	p.T280I	GLRX3_uc001lkn.1_Missense_Mutation_p.T280I|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	280	Glutaredoxin 2.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		GAATATGAAACATTCGATATA	0.323			NA											16	139					0	0	0.004007	0	0
MTG1	92170	broad.mit.edu	37	10	135233655	135233655	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr10:135233655G>C	uc001lnd.2	+	11	1095	c.991G>C	c.(991-993)GAG>CAG	p.E331Q	MTG1_uc010qve.1_Missense_Mutation_p.E196Q	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	331						mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		CCCCCCGGCTGAGACTTTGCC	0.662			NA											9	86					0	0	0.004482	0	0
OR51D1	390038	broad.mit.edu	37	11	4661548	4661548	+	Silent	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:4661548C>G	uc010qyk.1	+	1	528	c.528C>G	c.(526-528)CTC>CTG	p.L176L		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTTCATCCTCAAGTGGTTGT	0.507			NA											19	282					0	0	0.00278	0	0
RRP8	23378	broad.mit.edu	37	11	6623441	6623441	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:6623441G>C	uc001med.2	-	2	183	c.104C>G	c.(103-105)TCC>TGC	p.S35C	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	35					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						GCGGCGCTTGGAGCCCTGGAG	0.562			NA											7	156					0	0	0.00308	0	0
OR10A5	144124	broad.mit.edu	37	11	6867517	6867517	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:6867517G>C	uc001met.1	+	1	604	c.604G>C	c.(604-606)GTC>CTC	p.V202L		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTACGCCATCGTCGGAACCAT	0.512	Pancreas(44;21 1072 25662 28041 45559)		NA											4	252					0	0	0.009096	0	0
ASCL3	56676	broad.mit.edu	37	11	8959371	8959371	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:8959371T>G	uc001mhd.1	-	2	398	c.338A>C	c.(337-339)TAT>TCT	p.Y113S		NM_020646	NP_065697	Q9NQ33	ASCL3_HUMAN	ASCL3	112	Helix-loop-helix motif.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleolus	DNA binding				0				Epithelial(150;1.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0228)		GAGCTGGGCGTAGCCTTCATT	0.527			NA											4	130					0	0	0.001984	0	0
TPH1	7166	broad.mit.edu	37	11	18048086	18048086	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:18048086A>G	uc001mnp.2	-	6	780	c.754T>C	c.(754-756)TGC>CGC	p.C252R	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	252					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TATTGAGTGCAGTGAAAAACT	0.408			NA											8	103					0	0	0.004482	0	0
FIBIN	387758	broad.mit.edu	37	11	27016133	27016133	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:27016133C>T	uc001mrd.2	+	1	506	c.60C>T	c.(58-60)TTC>TTT	p.F20F		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	20						extracellular region|Golgi apparatus					0						AAGGCTACTTCGATGGCCCCC	0.542			NA											22	138					0	0	0.00333	0	0
MYBPC3	4607	broad.mit.edu	37	11	47362583	47362583	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:47362583T>C	uc001nfa.3	-	19	1953	c.1898A>G	c.(1897-1899)GAG>GGG	p.E633G	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	632	Ig-like C2-type 4.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		AATCTTGACCTCTGCAAGAGA	0.637			NA											4	12					0	0	0.001168	0	0
OR4X2	119764	broad.mit.edu	37	11	48266743	48266743	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:48266743A>C	uc001ngs.1	+	1	88	c.88A>C	c.(88-90)ATT>CTT	p.I30L		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTACACAGCAATTGTGCTGGG	0.448			NA											4	276					0	0	0.009096	0	0
PRG3	10394	broad.mit.edu	37	11	57144338	57144338	+	Missense_Mutation	SNP	G	G	T	rs141251058	byFrequency	TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:57144338G>T	uc001njv.1	-	6	773	c.663C>A	c.(661-663)TTC>TTA	p.F221L		NM_006093	NP_006084	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3 precursor	221	C-type lectin.				basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding				0						AGGAGCAGACGAAGGGCAGTT	0.602	Melanoma(154;1456 2519 19358 45229)		NA											18	281					1.2644e-06	1.38635e-06	0.010504	1	0
PRG2	5553	broad.mit.edu	37	11	57156549	57156549	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:57156549G>A	uc001njz.2	-	2	327	c.300C>T	c.(298-300)GGC>GGT	p.G100G	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Silent_p.G100G|PRG2_uc001nkb.2_Silent_p.G100G|PRG2_uc001nkd.2_Silent_p.G100G|PRG2_uc001nkc.2_Silent_p.G100G|PRG2_uc001nke.2_Silent_p.G380G	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	100					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	ACCCAGGGATGCCCACCACTT	0.542			NA											14	143					0	0	0.001855	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958704	57958704	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:57958704G>A	uc010rka.1	+	1	742	c.742G>A	c.(742-744)GTC>ATC	p.V248I		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				CCTCACTGCCGTCGCTCTTTT	0.577			NA											5	138					0	0	0.006214	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760896	62760896	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:62760896C>T	uc001nwo.2	-	10	1665	c.1529G>A	c.(1528-1530)TGG>TAG	p.W510*	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Nonsense_Mutation_p.W510*|SLC22A8_uc009yom.2_Nonsense_Mutation_p.W387*|SLC22A8_uc010rmm.1_Nonsense_Mutation_p.W419*|SLC22A8_uc009yon.2_Nonsense_Mutation_p.W510*	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	510	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						AGTGACTGACCAGTTTTCCAG	0.617			NA											10	123					0	0	0.006214	0	0
FZD4	8322	broad.mit.edu	37	11	86662507	86662507	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:86662507C>G	uc001pce.2	-	2	1597	c.1291G>C	c.(1291-1293)GAA>CAA	p.E431Q	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	431	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ATCAGTCTTTCTAACTTGTCT	0.413			NA											3	299					0	0	0.004672	0	0
TYR	7299	broad.mit.edu	37	11	88911903	88911903	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:88911903A>C	uc001pcs.2	+	1	864	c.782A>C	c.(781-783)AAC>ACC	p.N261T		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	261	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	ACAAATCCTAACTTACTCAGC	0.453			NA							Oculocutaneous_Albinism				16	99					0	0	0.007413	0	0
MAML2	84441	broad.mit.edu	37	11	95724744	95724744	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:95724744C>T	uc001pfw.1	-	3	3568	c.2283G>A	c.(2281-2283)CAG>CAA	p.Q761Q		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	761					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TGATCTGCCTCTGTAGAGTCT	0.453			NA	T	MECT1|CRTC3	salivary gland mucoepidermoid								5	195					0	0	0.001168	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120322385	120322385	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr11:120322385G>C	uc001pxl.1	+	22	2015	c.2008G>C	c.(2008-2010)GCT>CCT	p.A670P	ARHGEF12_uc009zat.2_Missense_Mutation_p.A651P|ARHGEF12_uc010rzn.1_Missense_Mutation_p.A567P|ARHGEF12_uc009zau.1_Missense_Mutation_p.A567P	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	670					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		GTCTTCTGTAGCTTCAGGGGC	0.463			NA	T	MLL	AML								5	42					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	12	92018	92018	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:92018T>C	uc010sdi.1	-	2	320	c.292A>G	c.(292-294)AGT>GGT	p.S98G	uc010sdj.1_RNA					SubName: Full=DEAD/H box polypeptide 11 like 11;												NA						GACTCCACACTCTCCTGGGTT	0.592			NA											2	7					0	0	0.004672	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6424195	6424195	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:6424195G>A	uc001qnr.2	+	4	467	c.319G>A	c.(319-321)GAG>AAG	p.E107K	PLEKHG6_uc001qns.2_Missense_Mutation_p.E107K|PLEKHG6_uc010sew.1_Missense_Mutation_p.E107K|PLEKHG6_uc010sex.1_Missense_Mutation_p.E75K	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	107					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						CCATGAGCTGGAGGTGAGGCT	0.642			NA											12	167					0	0	0.004007	0	0
A2M	2	broad.mit.edu	37	12	9232408	9232408	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:9232408T>C	uc001qvk.1	-	24	2971	c.2858A>G	c.(2857-2859)GAC>GGC	p.D953G	A2M_uc001qvj.1_5'UTR|A2M_uc009zgk.1_Missense_Mutation_p.D803G	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	953					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GCCTAATATGTCTCCTAGAGA	0.393			NA											5	29					0	0	0.001168	0	0
OR6C4	341418	broad.mit.edu	37	12	55945365	55945365	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:55945365G>C	uc010spp.1	+	1	355	c.355G>C	c.(355-357)GAT>CAT	p.D119H		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	119	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATGTCTTATGATCGTTATGT	0.443			NA											6	201					0	0	0.00308	0	0
SPRYD4	283377	broad.mit.edu	37	12	56862988	56862988	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:56862988C>G	uc001sli.3	+	2	326	c.251C>G	c.(250-252)ACC>AGC	p.T84S	SPRYD4_uc010sqo.1_Intron	NM_207344	NP_997227	Q8WW59	SPRY4_HUMAN	SPRY domain containing 4	84	B30.2/SPRY.					nucleus					0						ACAGCGGTCACCAGTGGCAGA	0.582			NA											11	202					0	0	0.004007	0	0
LRP1	4035	broad.mit.edu	37	12	57594926	57594926	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:57594926G>A	uc001snd.2	+	65	10801	c.10335G>A	c.(10333-10335)GAG>GAA	p.E3445E		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3445	Extracellular (Potential).|LDL-receptor class A 23.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGGAGGATGAGAGGGACTGCC	0.592			NA											16	230					0	0	0.00499	0	0
DCTN2	10540	broad.mit.edu	37	12	57927771	57927771	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:57927771G>A	uc001som.1	-	7	766	c.634C>T	c.(634-636)CGG>TGG	p.R212W	DCTN2_uc009zpu.1_Missense_Mutation_p.R217W|DCTN2_uc009zpv.1_Missense_Mutation_p.R125W|DCTN2_uc009zpw.1_Missense_Mutation_p.R125W|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Missense_Mutation_p.R125W|DCTN2_uc001sop.1_Missense_Mutation_p.R125W|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Missense_Mutation_p.R212W	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	212					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						TGCTCAGGCCGAGAATGTAGT	0.517			NA											10	114					0	0	0.006214	0	0
TMPO	7112	broad.mit.edu	37	12	98941397	98941397	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:98941397G>A	uc001tfj.2	+	9	1363	c.1126G>A	c.(1126-1128)GAA>AAA	p.E376K	TMPO_uc001tfk.2_Missense_Mutation_p.E267K|TMPO_uc001tfl.2_RNA	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	376	Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						CCGGCCATTAGAACTCAGTGA	0.418			NA											9	93					0	0	0.008291	0	0
ALDH2	217	broad.mit.edu	37	12	112230500	112230500	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:112230500G>A	uc001tst.2	+	9	1438	c.997G>A	c.(997-999)GAT>AAT	p.D333N	ALDH2_uc010syi.1_Missense_Mutation_p.D286N|ALDH2_uc009zvy.2_Missense_Mutation_p.D257N	NM_000690	NP_000681	P05091	ALDH2_HUMAN	mitochondrial aldehyde dehydrogenase 2	333					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase|electron carrier activity			skin(2)|ovary(1)|central_nervous_system(1)	4					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	GGACATCTATGATGAGTTTGT	0.632			NA	T	HMGA2	leiomyoma								3	22					0	0	0.009096	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138200	126138200	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:126138200C>T	uc001uhe.1	+	9	2189	c.2181C>T	c.(2179-2181)GTC>GTT	p.V727V	TMEM132B_uc001uhf.1_Silent_p.V239V	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	727	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CTGTTACTGTCTCATCATTGG	0.423			NA											61	166					0	0	0.01441	0	0
TNFRSF19	55504	broad.mit.edu	37	13	24200845	24200845	+	Splice_Site	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr13:24200845G>C	uc001uov.1	+	5	424	c.360_splice	c.e5-1	p.G120_splice	TNFRSF19_uc001uot.2_Splice_Site_p.G120_splice|TNFRSF19_uc010tcu.1_Splice_Site|TNFRSF19_uc001uow.2_Splice_Site_p.G120_splice	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,						apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TTCTCTTCTAGATTTTATAGG	0.428			NA											6	47					0	0	0.001168	0	0
ATP12A	479	broad.mit.edu	37	13	25284699	25284699	+	Silent	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr13:25284699G>C	uc001upp.2	+	20	3052	c.2865G>C	c.(2863-2865)CGG>CGC	p.R955R	ATP12A_uc010aaa.2_Silent_p.R961R	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	955	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ggaaaACCCGGAGGAATTCCA	0.433	Pancreas(156;1582 1935 18898 22665 26498)		NA											16	138					0	0	0.00499	0	0
TRPC4	7223	broad.mit.edu	37	13	38357157	38357157	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr13:38357157C>G	uc001uws.2	-	2	549	c.314G>C	c.(313-315)AGA>ACA	p.R105T	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.R105T|TRPC4_uc010tey.1_Missense_Mutation_p.R105T|TRPC4_uc010abw.2_Missense_Mutation_p.R105T|TRPC4_uc010abx.2_Missense_Mutation_p.R105T|TRPC4_uc010aby.2_Missense_Mutation_p.R105T	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	105	ANK 3.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GACTTCTTTTCTGATAGCATG	0.274			NA											4	60					0	0	0.000602	0	0
HECTD1	25831	broad.mit.edu	37	14	31602521	31602521	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr14:31602521C>T	uc001wrc.1	-	24	4334	c.3845G>A	c.(3844-3846)AGA>AAA	p.R1282K	HECTD1_uc001wrd.1_Missense_Mutation_p.R797K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1282	MIB/HERC2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ATCCAGGCCTCTGATAACACG	0.502			NA											13	75					0	0	0.001855	0	0
AKAP6	9472	broad.mit.edu	37	14	33293407	33293407	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr14:33293407G>C	uc001wrq.2	+	13	6558	c.6388G>C	c.(6388-6390)GAA>CAA	p.E2130Q		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2130					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CAATTACATAGAAGAGAAAAG	0.463	Melanoma(49;821 1200 7288 13647 42351)		NA											10	108					0	0	0.010729	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36190907	36190907	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr14:36190907C>T	uc001wti.2	-	16	2644	c.2253G>A	c.(2251-2253)CGG>CGA	p.R751R	RALGAPA1_uc001wtj.2_Silent_p.R751R|RALGAPA1_uc010tpv.1_Silent_p.R751R|RALGAPA1_uc010tpw.1_Silent_p.R751R|RALGAPA1_uc001wtk.1_Silent_p.R602R	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	751					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CAGTTTTTTGCCGTACTATAC	0.428			NA											4	205					0	0	0.009096	0	0
GCH1	2643	broad.mit.edu	37	14	55312565	55312565	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr14:55312565C>G	uc001xbh.1	-	5	708	c.547G>C	c.(547-549)GAG>CAG	p.E183Q	GCH1_uc001xbi.1_Missense_Mutation_p.E183Q|GCH1_uc001xbj.1_Missense_Mutation_p.E183Q|GCH1_uc001xbk.1_Missense_Mutation_p.E183Q|GCH1_uc010aol.1_Intron|GCH1_uc001xbl.1_Missense_Mutation_p.E183Q	NM_001024024	NP_001019195	P30793	GCH1_HUMAN	GTP cyclohydrolase 1 isoform 1	183					dopamine biosynthetic process|GTP catabolic process|neuromuscular process controlling posture|nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|protein homooligomerization|response to interferon-gamma|response to lipopolysaccharide|response to pain|response to tumor necrosis factor|tetrahydrobiopterin biosynthetic process|tetrahydrofolate biosynthetic process	cytoplasmic vesicle|cytosol|nuclear membrane|protein complex	GTP binding|GTP cyclohydrolase I activity|protein homodimerization activity|zinc ion binding			skin(1)	1						GTAAGGCGCTCCTGAACTGTG	0.453	Pancreas(198;1245 2204 4807 21567 38372)		NA											10	137					0	0	0.008291	0	0
EXD2	55218	broad.mit.edu	37	14	69697274	69697274	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr14:69697274C>G	uc001xkt.2	+	6	960	c.301C>G	c.(301-303)CGT>GGT	p.R101G	EXD2_uc001xku.2_5'UTR|EXD2_uc001xkv.2_Missense_Mutation_p.R226G|EXD2_uc001xkw.2_Missense_Mutation_p.R101G|EXD2_uc001xkx.2_RNA|EXD2_uc010aqt.2_Missense_Mutation_p.R226G|EXD2_uc010tte.1_Missense_Mutation_p.R226G|EXD2_uc001xky.2_Missense_Mutation_p.R101G	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	101	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						CCTTCTACTTCGTTGCAGCAA	0.408			NA											18	188					0	0	0.008871	0	0
TMEM63C	57156	broad.mit.edu	37	14	77685839	77685839	+	Splice_Site	SNP	A	A	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr14:77685839A>G	uc001xtf.2	+	4	363	c.151_splice	c.e4-2	p.L51_splice	TMEM63C_uc010asq.1_Splice_Site_p.L51_splice	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C							integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CCTGGCCTGTAGCTCGTCCTT	0.597			NA											3	185					0	0	0.00245	0	0
SERPINA5	5104	broad.mit.edu	37	14	95058516	95058516	+	Silent	SNP	C	C	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr14:95058516C>A	uc001ydm.2	+	6	1371	c.1161C>A	c.(1159-1161)CCC>CCA	p.P387P	SERPINA3_uc001ydo.3_Intron	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	387					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	TCAACAGGCCCTTTCTGATGT	0.557			NA											97	603					9.50263e-46	1.0803e-45	0.01441	1	0
OCA2	4948	broad.mit.edu	37	15	28260068	28260068	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr15:28260068C>A	uc001zbh.3	-	9	1008	c.898G>T	c.(898-900)GTG>TTG	p.V300L	OCA2_uc010ayv.2_Missense_Mutation_p.V300L	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	300	Extracellular (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CTGATGGACACCGTCTCTCTG	0.537			NA							Oculocutaneous_Albinism				9	25					2.31682e-05	2.51474e-05	0.003163	1	0
MYO5A	4644	broad.mit.edu	37	15	52645805	52645805	+	Silent	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr15:52645805G>C	uc002aby.2	-	27	3862	c.3618C>G	c.(3616-3618)CTC>CTG	p.L1206L	MYO5A_uc002abx.3_Silent_p.L1206L|MYO5A_uc010ugd.1_5'Flank|MYO5A_uc002aca.1_5'Flank|MYO5A_uc002acb.1_5'Flank|MYO5A_uc002acc.1_5'Flank	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1206	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CCATTACCTTGAGTGACTCAT	0.368			NA											5	111					0	0	0.001168	0	0
SRL	6345	broad.mit.edu	37	16	4242554	4242554	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr16:4242554C>T	uc002cvz.3	-	6	1035	c.1022G>A	c.(1021-1023)CGC>CAC	p.R341H	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	800						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						GGCGTGGATGCGGACCCGGAT	0.512			NA											6	310					0	0	0.001984	0	0
NOMO2	283820	broad.mit.edu	37	16	18555015	18555015	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr16:18555015G>C	uc002dfe.2	-	7	731	c.659C>G	c.(658-660)TCT>TGT	p.S220C	NOMO2_uc002dff.2_Missense_Mutation_p.S220C|NOMO2_uc010bvx.2_Missense_Mutation_p.S53C	NM_001004060	NP_001004060	Q5JPE7	NOMO2_HUMAN	nodal modulator 2 isoform 1	220	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			skin(1)	1						GACAGAGCCAGACACATTGTA	0.328			NA											4	43					0	0	0.00308	0	0
ATXN2L	11273	broad.mit.edu	37	16	28844383	28844383	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr16:28844383C>T	uc002drc.2	+	14	1831	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	uc010vct.1_Intron|ATXN2L_uc010byl.1_Nonsense_Mutation_p.Q531*|ATXN2L_uc002drb.2_Nonsense_Mutation_p.Q555*|ATXN2L_uc002dqy.2_Nonsense_Mutation_p.Q555*|ATXN2L_uc002dra.2_Nonsense_Mutation_p.Q555*|ATXN2L_uc002dqz.2_Nonsense_Mutation_p.Q555*|ATXN2L_uc010vdb.1_Nonsense_Mutation_p.Q561*|ATXN2L_uc002dre.2_Nonsense_Mutation_p.Q555*|ATXN2L_uc002drf.2_5'UTR|ATXN2L_uc002drg.2_5'Flank	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	555						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CTTCCAGCTTCAGCCCAGTAG	0.493			NA											6	280					0	0	0.00308	0	0
PHLPP2	23035	broad.mit.edu	37	16	71713353	71713353	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr16:71713353C>T	uc002fax.2	-	6	982	c.976G>A	c.(976-978)GAG>AAG	p.E326K	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Missense_Mutation_p.E326K|PHLPP2_uc002fay.1_Missense_Mutation_p.E326K	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	326	LRR 4.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						AGGTTGAGCTCAGTCAGGGTA	0.398			NA											10	96					0	0	0.008291	0	0
C17orf39	79018	broad.mit.edu	37	17	17948480	17948480	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr17:17948480C>G	uc002gsg.1	+	2	626	c.458C>G	c.(457-459)TCT>TGT	p.S153C		NM_024052	NP_076957	Q8IVV7	CQ039_HUMAN	hypothetical protein LOC79018	153										skin(1)	1	all_neural(463;0.228)					ACGGGGAACTCTTACCTTTGT	0.468			NA											6	68					0	0	0.004482	0	0
ALDH3A1	218	broad.mit.edu	37	17	19641686	19641686	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr17:19641686G>C	uc010cqu.2	-	9	1627	c.1297C>G	c.(1297-1299)CTG>GTG	p.L433V	ALDH3A1_uc010vzd.1_Missense_Mutation_p.L433V|ALDH3A1_uc002gwj.2_Missense_Mutation_p.L433V|ALDH3A1_uc010cqv.2_Missense_Mutation_p.L432V|ALDH3A1_uc002gwk.2_Missense_Mutation_p.L550V|ALDH3A1_uc002gwl.1_Missense_Mutation_p.L360V	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	433					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TCATTCATCAGAGGCCTCACC	0.622			NA											39	213					0	0	0.01441	0	0
CNP	1267	broad.mit.edu	37	17	40125572	40125572	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr17:40125572G>A	uc002hyl.1	+	4	1040	c.896G>A	c.(895-897)CGG>CAG	p.R299Q	CNP_uc010wfz.1_Missense_Mutation_p.R176Q|CNP_uc002hym.1_Missense_Mutation_p.R279Q|CNP_uc010wga.1_Missense_Mutation_p.R64Q|CNP_uc002hyn.1_Missense_Mutation_p.R64Q	NM_033133	NP_149124	P09543	CN37_HUMAN	2',3'-cyclic nucleotide 3' phosphodiesterase	299					cell killing|cyclic nucleotide catabolic process|RNA metabolic process|synaptic transmission	extracellular space|melanosome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|ATP binding|protein binding				0		all_cancers(22;2.38e-06)|all_epithelial(22;6.79e-05)|Breast(137;0.000143)		UCEC - Uterine corpus endometrioid carcinoma (308;0.171)		ACTGGGGCCCGGGTGGAGTTA	0.587			NA											6	351					0	0	0.001984	0	0
ABCC3	8714	broad.mit.edu	37	17	48738458	48738458	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr17:48738458C>G	uc002isl.2	+	8	1061	c.981C>G	c.(979-981)ATC>ATG	p.I327M	ABCC3_uc002isk.3_Missense_Mutation_p.I327M|ABCC3_uc002ism.2_5'Flank	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	327	Extracellular (By similarity).|ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TCTCCTTCATCAATCCACAGC	0.592			NA											3	79					0	0	0.004672	0	0
CCDC47	57003	broad.mit.edu	37	17	61843460	61843460	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr17:61843460C>A	uc002jbs.3	-	2	412	c.76G>T	c.(76-78)GAG>TAG	p.E26*	CCDC47_uc010ddx.2_Nonsense_Mutation_p.E26*|CCDC47_uc002jbt.2_Nonsense_Mutation_p.E26*	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	26						integral to membrane	protein binding				0						TCCTCATCCTCAAAATCATCA	0.408			NA											18	225					1.01871e-10	1.14011e-10	0.008871	1	0
AZI1	22994	broad.mit.edu	37	17	79168681	79168681	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr17:79168681A>G	uc002jzp.1	-	17	2317	c.2117T>C	c.(2116-2118)GTC>GCC	p.V706A	AZI1_uc002jzm.1_Missense_Mutation_p.V133A|AZI1_uc002jzn.1_Missense_Mutation_p.V703A|AZI1_uc002jzo.1_Missense_Mutation_p.V703A|AZI1_uc010wum.1_Missense_Mutation_p.V706A|AZI1_uc002jzq.2_5'Flank	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	706					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TCGGACAGTGACCTCCTTGAT	0.552			NA											46	475					0	0	0.01441	0	0
DSC1	1823	broad.mit.edu	37	18	28712647	28712647	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr18:28712647G>A	uc002kwn.2	-	14	2384	c.2122C>T	c.(2122-2124)CTG>TTG	p.L708L	DSC1_uc002kwm.2_Silent_p.L708L	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	708	Helical; (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CATGTAAACAGAATACCTAAA	0.303			NA											6	28					0	0	0.001168	0	0
MOCOS	55034	broad.mit.edu	37	18	33775270	33775270	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr18:33775270C>T	uc002kzq.3	+	2	216	c.193C>T	c.(193-195)CTC>TTC	p.L65F		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	65					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	CCAGAGCCAGCTCGAAAGCTT	0.393			NA											13	118					0	0	0.003163	0	0
RNF152	220441	broad.mit.edu	37	18	59483267	59483267	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr18:59483267C>T	uc002lih.1	-	2	842	c.430G>A	c.(430-432)GGT>AGT	p.G144S		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	144					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				GGAGCCCCACCTTGCAGAGGC	0.672			NA											4	61					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9057667	9057667	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr19:9057667G>A	uc002mkp.2	-	3	29983	c.29779C>T	c.(29779-29781)CAG>TAG	p.Q9927*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9929	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATCGTGGACTGATCAGAGTCA	0.448			NA											10	287					0	0	0.010504	0	0
ZNF99	7652	broad.mit.edu	37	19	22941400	22941400	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr19:22941400G>A	uc010xrh.1	-	5	1038	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TAAGGGCTGAGAAACGCTTAA	0.368			NA											6	46					0	0	0.001168	0	0
ZNF536	9745	broad.mit.edu	37	19	30936293	30936293	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr19:30936293G>A	uc002nsu.1	+	2	1962	c.1824G>A	c.(1822-1824)TTG>TTA	p.L608L	ZNF536_uc010edd.1_Silent_p.L608L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	608					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGATTTTTTGTCACACGGGC	0.552			NA											22	166					0	0	0.010504	0	0
ALKBH6	84964	broad.mit.edu	37	19	36501474	36501474	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr19:36501474C>T	uc002oct.2	-	6	548	c.448G>A	c.(448-450)GAA>AAA	p.E150K	C19orf46_uc002ocr.1_5'Flank|C19orf46_uc002ocs.1_5'Flank|C19orf46_uc002ocq.1_5'Flank|C19orf46_uc010een.1_5'Flank|ALKBH6_uc002ocv.1_Missense_Mutation_p.E178K|ALKBH6_uc002ocx.1_Missense_Mutation_p.E81K|ALKBH6_uc002ocw.1_3'UTR|ALKBH6_uc010eeo.1_Missense_Mutation_p.E150K|ALKBH6_uc010eep.1_3'UTR	NM_032878	NP_116267	Q3KRA9	ALKB6_HUMAN	alkB, alkylation repair homolog 6 isoform 2	150	Fe2OG dioxygenase.					cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_lung(56;1.35e-06)|Lung NSC(56;2.15e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCCACCTGTTCTGTAGGGTCA	0.622			NA											8	124					0	0	0.008291	0	0
ZNF227	7770	broad.mit.edu	37	19	44740468	44740468	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr19:44740468G>C	uc002oyu.2	+	6	2090	c.1885G>C	c.(1885-1887)GAG>CAG	p.E629Q	ZNF227_uc010xwu.1_Missense_Mutation_p.E578Q|ZNF227_uc002oyv.2_Missense_Mutation_p.E629Q|ZNF227_uc010xwv.1_Missense_Mutation_p.E578Q|ZNF227_uc010xww.1_Missense_Mutation_p.E550Q|ZNF227_uc002oyw.2_Missense_Mutation_p.E601Q|ZNF227_uc010ejh.2_Missense_Mutation_p.E622Q|ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_3'UTR	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	629					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				CCATACTGGAGAGAAGCCATA	0.463			NA											4	63					0	0	0.009096	0	0
NLRP13	126204	broad.mit.edu	37	19	56424091	56424091	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr19:56424091C>G	uc010ygg.1	-	5	1117	c.1092G>C	c.(1090-1092)AAG>AAC	p.K364N		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	364	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAAACCAGGTCTTGATCGTGA	0.458			NA											22	153					0	0	0.014323	0	0
SDC1	6382	broad.mit.edu	37	2	20403660	20403660	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:20403660C>G	uc002rdo.1	-	3	840	c.541G>C	c.(541-543)GAG>CAG	p.E181Q	SDC1_uc002rdp.1_Missense_Mutation_p.E181Q|SDC1_uc010exv.2_Intron	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	181	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCTCCATCCTCTGTGTGGGGA	0.657			NA											25	104					0	0	0.008361	0	0
ABHD1	84696	broad.mit.edu	37	2	27352658	27352658	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:27352658G>C	uc002rit.2	+	6	814	c.654G>C	c.(652-654)CAG>CAC	p.Q218H	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_RNA	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	218						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGCCAGGCAGGCTGCAGGGC	0.542			NA											23	104					0	0	0.007291	0	0
SNRNP200	23020	broad.mit.edu	37	2	96956196	96956196	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:96956196G>A	uc002svu.2	-	20	2696	c.2610C>T	c.(2608-2610)ATC>ATT	p.I870I	SNRNP200_uc002svw.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	870	Helicase C-terminal 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CATGAGATGTGATGAGTATGC	0.483			NA											14	173					0	0	0.003163	0	0
SNRNP200	23020	broad.mit.edu	37	2	96956427	96956427	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:96956427G>A	uc002svu.2	-	19	2634	c.2548C>T	c.(2548-2550)CTG>TTG	p.L850L	SNRNP200_uc002svw.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	850	Helicase C-terminal 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						TGTACCTGCAGAATGTCCAGT	0.502			NA											27	346					0	0	0.005443	0	0
TMEM177	80775	broad.mit.edu	37	2	120439041	120439041	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:120439041C>T	uc010flg.1	+	2	1085	c.612C>T	c.(610-612)TTC>TTT	p.F204F	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Silent_p.F204F|TMEM177_uc002tmd.2_Silent_p.F204F|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	204	Helical; (Potential).					integral to membrane				ovary(1)	1	Colorectal(110;0.196)					GGGCTGCCTTCAGCTTGGTGG	0.657			NA											4	64					0	0	0.001168	0	0
KYNU	8942	broad.mit.edu	37	2	143642955	143642955	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:143642955G>C	uc002tvl.2	+	2	149	c.19G>C	c.(19-21)GAG>CAG	p.E7Q	KYNU_uc002tvk.2_Missense_Mutation_p.E7Q|KYNU_uc010fnm.2_Missense_Mutation_p.E7Q	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	7					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTCATCTCTTGAGCTGCCGGC	0.453			NA											7	47					0	0	0.00308	0	0
SCRN3	79634	broad.mit.edu	37	2	175268854	175268854	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:175268854C>T	uc002uiq.2	+	5	653	c.565C>T	c.(565-567)CAA>TAA	p.Q189*	SCRN3_uc010zen.1_Nonsense_Mutation_p.Q182*|SCRN3_uc010zeo.1_5'UTR	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	189					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			TATTTCTAATCAACTTTCCAT	0.368			NA											3	48					0	0	0.009096	0	0
TMEFF2	23671	broad.mit.edu	37	2	193059202	193059202	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:193059202C>T	uc002utc.2	-	1	443	c.49G>A	c.(49-51)GAG>AAG	p.E17K	TMEFF2_uc002utd.1_Missense_Mutation_p.E17K	NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	17						extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			CAAAAGCCCTCGCAAAGTGTC	0.592	Pancreas(50;1277 1381 28487 47072)		NA											6	42					0	0	0.008291	0	0
HECW2	57520	broad.mit.edu	37	2	197106927	197106927	+	Silent	SNP	A	A	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:197106927A>G	uc002utm.1	-	20	3714	c.3531T>C	c.(3529-3531)GGT>GGC	p.G1177G	HECW2_uc002utl.1_Silent_p.G821G	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1177					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CACGCTGGGTACCTGCAGCAA	0.473			NA											27	119					0	0	0.007291	0	0
CCDC150	284992	broad.mit.edu	37	2	197531497	197531497	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:197531497C>G	uc002utp.1	+	7	952	c.817C>G	c.(817-819)CAA>GAA	p.Q273E	CCDC150_uc002uto.1_Missense_Mutation_p.Q273E|CCDC150_uc010zgq.1_Intron|CCDC150_uc010zgr.1_Intron|CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	273	Potential.										0						ACAGAGCGCTCAAGAACTACT	0.358			NA											6	21					0	0	0.001984	0	0
ABCA12	26154	broad.mit.edu	37	2	215851396	215851396	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:215851396C>T	uc002vew.2	-	28	4253	c.4033G>A	c.(4033-4035)GGG>AGG	p.G1345R	ABCA12_uc002vev.2_Missense_Mutation_p.G1027R|ABCA12_uc010zjn.1_Missense_Mutation_p.G272R	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1345					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGGGCAACCCCGACTGTGAGA	0.433	Ovarian(66;664 1488 5121 34295)		NA											4	72					0	0	0.009096	0	0
DNAJB2	3300	broad.mit.edu	37	2	220147600	220147600	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:220147600C>T	uc002vkx.1	+	6	631	c.394C>T	c.(394-396)CGA>TGA	p.R132*	DNAJB2_uc002vkw.1_Nonsense_Mutation_p.R132*|DNAJB2_uc002vky.2_5'UTR|DNAJB2_uc010zlb.1_5'UTR	NM_006736	NP_006727	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	132					ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding				0		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCGGGGTTCCCGACACTCAGG	0.537			NA											14	158					0	0	0.003163	0	0
PER2	8864	broad.mit.edu	37	2	239170885	239170885	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr2:239170885G>A	uc002vyc.2	-	11	1491	c.1254C>T	c.(1252-1254)ATC>ATT	p.I418I	PER2_uc010znv.1_Silent_p.I418I|PER2_uc010znw.1_Silent_p.I418I|PER2_uc010fyx.1_Nonsense_Mutation_p.Q383*	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	418	PAC.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TCCATGGGTTGATGAAGCTGG	0.592			NA											5	94					0	0	0.000602	0	0
NCOA6	23054	broad.mit.edu	37	20	33338106	33338106	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr20:33338106G>A	uc002xav.2	-	10	4463	c.1892C>T	c.(1891-1893)TCC>TTC	p.S631F	NCOA6_uc002xaw.2_Missense_Mutation_p.S631F	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	631	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CTGGCCCTGGGAGGGCACGAT	0.572			NA											4	132					0	0	0.000602	0	0
EDEM2	55741	broad.mit.edu	37	20	33722746	33722746	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr20:33722746T>A	uc002xbo.2	-	6	597	c.497A>T	c.(496-498)CAG>CTG	p.Q166L	EDEM2_uc010zuv.1_Missense_Mutation_p.Q125L|EDEM2_uc010zus.1_5'UTR|EDEM2_uc002xbq.2_Missense_Mutation_p.Q129L|EDEM2_uc010zut.1_Missense_Mutation_p.Q125L|EDEM2_uc002xbp.2_Missense_Mutation_p.Q14L|EDEM2_uc002xbn.2_Missense_Mutation_p.Q14L|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Intron	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	166					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGTGGGGGTCTGAAAGGCTGA	0.532	Esophageal Squamous(51;906 1021 24535 36410 39145)		NA											14	46					0	0	0.00245	0	0
PLCG1	5335	broad.mit.edu	37	20	39795229	39795229	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr20:39795229C>G	uc002xjp.1	+	18	2235	c.2114C>G	c.(2113-2115)TCT>TGT	p.S705C	PLCG1_uc002xjo.1_Missense_Mutation_p.S705C|PLCG1_uc010zwe.1_Missense_Mutation_p.S331C|PLCG1_uc010ggf.2_Missense_Mutation_p.S55C	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	705	SH2 2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				TATGCCATCTCTTTCCGGTGA	0.592			NA											7	131					0	0	0.001984	0	0
TRMT2A	27037	broad.mit.edu	37	22	20102949	20102949	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr22:20102949C>G	uc002zrk.1	-	5	945	c.730G>C	c.(730-732)GAG>CAG	p.E244Q	TRMT2A_uc002zrl.1_Missense_Mutation_p.E244Q|TRMT2A_uc002zrm.1_Missense_Mutation_p.E66Q|TRMT2A_uc002zrn.1_Missense_Mutation_p.E244Q|TRMT2A_uc011ahk.1_3'UTR|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	244					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						ACCAGAAACTCACACTTATTA	0.607			NA											4	134					0	0	0.009096	0	0
MCM5	4174	broad.mit.edu	37	22	35802587	35802587	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr22:35802587C>T	uc003anu.3	+	5	559	c.465C>T	c.(463-465)ATC>ATT	p.I155I	MCM5_uc010gwr.2_5'UTR|MCM5_uc003anv.3_Silent_p.I112I|MCM5_uc010gws.1_5'Flank	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	155					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						CTGGCATCATCATCGCGGCCT	0.592			NA											5	66					0	0	0.001168	0	0
MYH9	4627	broad.mit.edu	37	22	36737460	36737460	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr22:36737460G>C	uc003apg.2	-	3	676	c.445C>G	c.(445-447)CAC>GAC	p.H149D	MYH9_uc003aph.1_Missense_Mutation_p.H13D|MYH9_uc003api.1_Missense_Mutation_p.H149D	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	149	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GCATAGATGTGAGGGGGCATC	0.522			NA	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				10	162					0	0	0.010729	0	0
MPPED1	758	broad.mit.edu	37	22	43870650	43870650	+	Silent	SNP	A	A	T	rs143130815	by1000genomes	TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr22:43870650A>T	uc011apv.1	+	4	664	c.441A>T	c.(439-441)GCA>GCT	p.A147A	MPPED1_uc011apw.1_Silent_p.A41A|MPPED1_uc011apx.1_5'UTR|MPPED1_uc011apy.1_Silent_p.A147A|MPPED1_uc011apz.1_Silent_p.A180A	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	147							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				TCGTGATCGCAGGCAACCACG	0.562			NA											4	143					0	0	0.009096	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47274580	47274580	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr22:47274580C>G	uc003bib.2	+	5	804	c.669C>G	c.(667-669)ATC>ATG	p.I223M	TBC1D22A_uc010haf.2_Missense_Mutation_p.I193M|TBC1D22A_uc003bic.2_Missense_Mutation_p.I164M|TBC1D22A_uc003bie.2_Missense_Mutation_p.I145M|TBC1D22A_uc003bid.2_Intron|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.I176M	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	223	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GGTCCGGAATCCCTAAGCCAG	0.522			NA											6	152					0	0	0.00308	0	0
DLEC1	9940	broad.mit.edu	37	3	38151719	38151719	+	Silent	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:38151719C>G	uc003cho.1	+	23	3411	c.3390C>G	c.(3388-3390)CTC>CTG	p.L1130L	DLEC1_uc003chp.1_Silent_p.L1130L|DLEC1_uc010hgv.1_Silent_p.L1133L|DLEC1_uc003chr.1_Silent_p.L236L|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1130					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTTTCTCCCTCAAGTTTGAGT	0.557			NA											15	177					0	0	0.00245	0	0
CACNA1D	776	broad.mit.edu	37	3	53785859	53785859	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:53785859C>G	uc003dgv.3	+	28	3763	c.3600C>G	c.(3598-3600)TAC>TAG	p.Y1200*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.Y1220*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.Y1200*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.Y867*|CACNA1D_uc003dgx.1_Nonsense_Mutation_p.Y348*	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1200	IV.|Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AGTTCTGGTACGTGGTGAACT	0.493			NA											27	302					0	0	0.00632	0	0
C3orf38	285237	broad.mit.edu	37	3	88205273	88205273	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:88205273C>G	uc003dqw.2	+	4	789	c.478C>G	c.(478-480)CTA>GTA	p.L160V		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	160					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		GAATCCTTTTCTAGGACCACC	0.388			NA											4	90					0	0	0.000602	0	0
SIDT1	54847	broad.mit.edu	37	3	113285349	113285349	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:113285349A>C	uc003eak.2	+	2	956	c.305A>C	c.(304-306)GAG>GCG	p.E102A	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.E102A|SIDT1_uc011big.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	102	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						CAGCAGAAAGAGGTGCTGTCC	0.493			NA											4	182					0	0	0.000602	0	0
KIAA2018	205717	broad.mit.edu	37	3	113378190	113378190	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:113378190G>A	uc003eam.2	-	7	2750	c.2339C>T	c.(2338-2340)TCA>TTA	p.S780L	KIAA2018_uc003eal.2_Missense_Mutation_p.S724L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	780					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						AGTGTTCATTGAGGAAGTACT	0.423			NA											12	139					0	0	0.001855	0	0
ATR	545	broad.mit.edu	37	3	142255000	142255000	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:142255000C>G	uc003eux.3	-	20	3891	c.3769G>C	c.(3769-3771)GAT>CAT	p.D1257H		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1257					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TCTGGATGATCAGGTAAAAAA	0.269			NA						Other_conserved_DNA_damage_response_genes					8	78					0	0	0.004482	0	0
SLC33A1	9197	broad.mit.edu	37	3	155571730	155571730	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:155571730G>A	uc003fan.3	-	1	438	c.57C>T	c.(55-57)TTC>TTT	p.F19F	SLC33A1_uc003fao.1_Silent_p.F19F	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	19	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GAGAGTGACTGAAATTCCCTG	0.617			NA											5	34					0	0	0.006214	0	0
ARPM1	84517	broad.mit.edu	37	3	169485492	169485492	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:169485492C>T	uc003ffs.1	-	2	1222	c.847G>A	c.(847-849)GAT>AAT	p.D283N	TERC_uc003ffr.1_5'Flank	NM_032487	NP_115876	Q9BYD9	ARPM1_HUMAN	actin related protein M1	283						cytoplasm|cytoskeleton					0	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;5.01e-59)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AGGCCTGTATCACATTTCATT	0.453			NA											15	248					0	0	0.004007	0	0
LRCH3	84859	broad.mit.edu	37	3	197581296	197581296	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr3:197581296G>A	uc011bul.1	+	14	1629	c.1624G>A	c.(1624-1626)GAT>AAT	p.D542N	LRCH3_uc003fyj.1_Missense_Mutation_p.D542N|LRCH3_uc011bum.1_Missense_Mutation_p.D514N|LRCH3_uc011bun.1_Missense_Mutation_p.D388N|LRCH3_uc003fyk.2_Missense_Mutation_p.D137N	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	542						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		TCAGCACACTGATGATAGTGC	0.423			NA											19	95					0	0	0.008871	0	0
ATP8A1	10396	broad.mit.edu	37	4	42457409	42457409	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr4:42457409G>C	uc003gwr.2	-	29	2954	c.2722C>G	c.(2722-2724)CTT>GTT	p.L908V	ATP8A1_uc003gwq.2_Missense_Mutation_p.L134V|ATP8A1_uc003gws.2_Missense_Mutation_p.L893V	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	908	Helical; (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	AATATTCCAAGAGTTAAAGGA	0.403			NA											6	98					0	0	0.001984	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68812269	68812269	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr4:68812269C>T	uc003hdr.1	-	2	153	c.32G>A	c.(31-33)CGA>CAA	p.R11Q	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.R11Q	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	11	Cytoplasmic (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						ATTTCTGCTTCGGGTGCCAAA	0.488	NSCLC(26;2 894 10941 14480 22546)		NA											5	55					0	0	0.001168	0	0
BANK1	55024	broad.mit.edu	37	4	102839186	102839186	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr4:102839186G>T	uc003hvy.3	+	7	1320	c.1046G>T	c.(1045-1047)TGT>TTT	p.C349F	BANK1_uc003hvx.3_Missense_Mutation_p.C334F|BANK1_uc010ill.2_Missense_Mutation_p.C216F|BANK1_uc003hvz.3_Missense_Mutation_p.C319F	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	349	ANK 1.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		CTTCTCCACTGTGCAGCAAAA	0.378			NA											22	62					1.55469e-16	1.74903e-16	0.00333	1	0
ANKRD50	57182	broad.mit.edu	37	4	125591892	125591892	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr4:125591892C>A	uc003ifg.3	-	3	2806	c.2540G>T	c.(2539-2541)GGA>GTA	p.G847V	ANKRD50_uc011cgo.1_Missense_Mutation_p.G668V|ANKRD50_uc010inw.2_Missense_Mutation_p.G847V	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	847	ANK 12.									central_nervous_system(1)	1						AGGTGTCCATCCAGCATCATC	0.433			NA											11	186					4.36969e-10	4.84027e-10	0.001855	1	0
SDHA	6389	broad.mit.edu	37	5	251536	251536	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:251536G>C	uc003jao.3	+	13	1862	c.1747G>C	c.(1747-1749)GAG>CAG	p.E583Q	SDHA_uc011clv.1_Missense_Mutation_p.E583Q|SDHA_uc011clw.1_Missense_Mutation_p.E535Q|SDHA_uc003jap.3_Intron|SDHA_uc003jaq.3_Missense_Mutation_p.E358Q|SDHA_uc003jar.3_Missense_Mutation_p.E177Q	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	583					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CTACGGAGCAGAGGCACGGAA	0.612			NA							Familial_Paragangliomas				9	206					0	0	0.008291	0	0
IRX1	79192	broad.mit.edu	37	5	3600724	3600724	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:3600724G>A	uc003jde.2	+	3	1366	c.1314G>A	c.(1312-1314)GAG>GAA	p.E438E		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	438						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CTCTCGCAGAGAGAGACCTCG	0.607			NA											4	228					0	0	0.000602	0	0
MYO10	4651	broad.mit.edu	37	5	16701570	16701570	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:16701570C>T	uc003jft.3	-	25	3402	c.2934G>A	c.(2932-2934)GAG>GAA	p.E978E	MYO10_uc011cnc.1_5'Flank|MYO10_uc011cnd.1_Silent_p.E335E|MYO10_uc011cne.1_Silent_p.E335E|MYO10_uc010itx.2_Silent_p.E601E	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	978					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						AGTTGGGCTTCTCCTCGCATG	0.597			NA											5	41					0	0	0.000602	0	0
CDH6	1004	broad.mit.edu	37	5	31317488	31317488	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:31317488C>G	uc003jhe.1	+	10	1845	c.1519C>G	c.(1519-1521)CAG>GAG	p.Q507E	CDH6_uc003jhd.1_Missense_Mutation_p.Q507E	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	507	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TTAGTTGATTCAGACCCTGCA	0.383			NA											9	87					0	0	0.010729	0	0
PLK2	10769	broad.mit.edu	37	5	57753340	57753340	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:57753340C>T	uc003jrn.2	-	6	911	c.784G>A	c.(784-786)GAC>AAC	p.D262N		NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	262	Protein kinase.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		GCCCAAATGTCTGATTCACAG	0.373			NA											8	66					0	0	0.004482	0	0
PPWD1	23398	broad.mit.edu	37	5	64867882	64867882	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:64867882G>A	uc003jtv.3	+	5	745	c.738G>A	c.(736-738)ATG>ATA	p.M246I	PPWD1_uc011cqv.1_Missense_Mutation_p.M216I|PPWD1_uc011cqw.1_Missense_Mutation_p.M90I	NM_015342	NP_056157	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat	246	WD 3.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		AATCTGGGATGATTGAATACT	0.378			NA											4	111					0	0	0.009096	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65288649	65288649	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:65288649G>C	uc003juk.1	+	3	411	c.103G>C	c.(103-105)GAA>CAA	p.E35Q	ERBB2IP_uc003juh.1_Missense_Mutation_p.E35Q|ERBB2IP_uc003jui.1_Missense_Mutation_p.E35Q|ERBB2IP_uc003juj.1_Missense_Mutation_p.E35Q|ERBB2IP_uc011cqx.1_Missense_Mutation_p.E35Q|ERBB2IP_uc011cqy.1_Missense_Mutation_p.E35Q|ERBB2IP_uc011cqz.1_Missense_Mutation_p.E35Q|ERBB2IP_uc010iwx.1_Missense_Mutation_p.E35Q|ERBB2IP_uc003jul.1_Missense_Mutation_p.E35Q	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	35	LRR 1.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TTGCAGCTTAGAACAAGTTCC	0.393			NA											6	140					0	0	0.001984	0	0
MAST4	375449	broad.mit.edu	37	5	66460707	66460707	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:66460707G>A	uc003jut.1	+	28	5201	c.5133G>A	c.(5131-5133)AGG>AGA	p.R1711R	MAST4_uc003juw.2_Silent_p.R1639R|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1903						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGAGGGACAGGAAAGGTCCCC	0.567			NA											6	69					0	0	0.004482	0	0
CD180	4064	broad.mit.edu	37	5	66480332	66480332	+	Silent	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:66480332C>G	uc003juy.2	-	3	487	c.339G>C	c.(337-339)CTG>CTC	p.L113L		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	113	LRR 3.|Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CCATGAATATCAGGGGATTTC	0.393			NA											18	180					0	0	0.007413	0	0
ENC1	8507	broad.mit.edu	37	5	73931322	73931322	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:73931322C>G	uc003kdc.3	-	2	2120	c.989G>C	c.(988-990)AGA>ACA	p.R330T	ENC1_uc011css.1_Missense_Mutation_p.R257T	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	330	Kelch 1.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		AAACTCTTTTCTTGGGCTGGG	0.478			NA											10	233					0	0	0.010729	0	0
F2R	2149	broad.mit.edu	37	5	76028674	76028674	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:76028674G>A	uc003ken.3	+	2	889	c.624G>A	c.(622-624)ATG>ATA	p.M208I		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	208	Cytoplasmic (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	TGTATCCCATGCAGTCCCTCT	0.542			NA											37	242					0	0	0.004289	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101595922	101595922	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:101595922G>C	uc003knm.2	-	6	1410	c.1123C>G	c.(1123-1125)CTA>GTA	p.L375V		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	375	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TTTACCTTTAGAGCAGCTGGA	0.264			NA											3	15					0	0	0.004672	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101755593	101755593	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:101755593A>T	uc003knn.2	-	8	1581	c.1409T>A	c.(1408-1410)GTG>GAG	p.V470E	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Missense_Mutation_p.V470E|SLCO6A1_uc003knq.2_Missense_Mutation_p.V408E	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	470	Helical; Name=9; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AATAATAAACACAAGCAGTAT	0.338			NA											13	68					0	0	0.00245	0	0
CD14	929	broad.mit.edu	37	5	140012043	140012043	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:140012043T>G	uc003lgi.1	-	2	880	c.526A>C	c.(526-528)AGC>CGC	p.S176R	CD14_uc003lgj.1_Missense_Mutation_p.S176R	NM_000591	NP_000582	P08571	CD14_HUMAN	CD14 antigen precursor	176	LRR 5.				apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCAATGCTCAGTACCTTG	0.617			NA											10	54					0	0	0.003163	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140890710	140890710	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:140890710G>C	uc003lla.1	+	4	2805	c.2805G>C	c.(2803-2805)AAG>AAC	p.K935N	PCDHGA1_uc003lji.1_Missense_Mutation_p.K922N|PCDHGA2_uc003ljk.1_Missense_Mutation_p.K923N|PCDHGA3_uc003ljm.1_Missense_Mutation_p.K923N|PCDHGA3_uc010jfx.1_Missense_Mutation_p.K683N|PCDHGB1_uc003ljo.1_Missense_Mutation_p.K918N|PCDHGA4_uc003ljq.1_Missense_Mutation_p.K922N|PCDHGB2_uc003ljs.1_Missense_Mutation_p.K922N|PCDHGA5_uc003lju.1_Missense_Mutation_p.K922N|PCDHGB3_uc003ljw.1_Missense_Mutation_p.K920N|PCDHGA6_uc003ljy.1_Missense_Mutation_p.K923N|PCDHGA7_uc003lka.1_Missense_Mutation_p.K923N|PCDHGB4_uc003lkc.1_Missense_Mutation_p.K914N|PCDHGA8_uc003lkd.1_Missense_Mutation_p.K923N|PCDHGB5_uc003lkf.1_Missense_Mutation_p.K914N|PCDHGA9_uc003lkh.1_Missense_Mutation_p.K923N|PCDHGB6_uc003lkj.1_Missense_Mutation_p.K921N|PCDHGA10_uc003lkl.1_Missense_Mutation_p.K927N|PCDHGB7_uc003lkn.1_Missense_Mutation_p.K920N|PCDHGA11_uc003lkp.1_Missense_Mutation_p.K741N|PCDHGA11_uc003lkq.1_Missense_Mutation_p.K926N|PCDHGA12_uc003lkt.1_Missense_Mutation_p.K923N|PCDHGC3_uc003lkv.1_Missense_Mutation_p.K925N|PCDHGC3_uc003lkw.1_Missense_Mutation_p.K125N|PCDHGC4_uc003lky.1_Missense_Mutation_p.K929N	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	935	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGCAACAAGAAGAAGTCGG	0.597			NA											8	97					0	0	0.004482	0	0
HMP19	51617	broad.mit.edu	37	5	173531304	173531304	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:173531304C>G	uc003mcx.2	+	4	432	c.287C>G	c.(286-288)ACC>AGC	p.T96S	HMP19_uc011dfh.1_5'UTR	NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	96	Lumenal (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			AAAGCCTTCACCTATGATCAC	0.473			NA											15	72					0	0	0.007413	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026184	176026184	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:176026184C>G	uc003meo.1	-	2	827	c.652G>C	c.(652-654)GAT>CAT	p.D218H		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	218						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACAAAGGATCTACTTTTCCC	0.517			NA											15	176					0	0	0.004007	0	0
ZFP2	80108	broad.mit.edu	37	5	178359365	178359365	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:178359365G>A	uc003mjn.1	+	5	1560	c.1051G>A	c.(1051-1053)GAG>AAG	p.E351K	ZFP2_uc010jky.2_Missense_Mutation_p.E351K|ZFP2_uc010jkx.1_Missense_Mutation_p.E351K	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TCACACTGGAGAGAAACCTTA	0.413			NA											7	87					0	0	0.001984	0	0
PAK1IP1	55003	broad.mit.edu	37	6	10707679	10707679	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr6:10707679G>C	uc003mzg.2	+	8	803	c.772G>C	c.(772-774)GAG>CAG	p.E258Q		NM_017906	NP_060376	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	258	WD 5.				negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				TGAAATTCCAGAGCATCATGT	0.328			NA											11	226					0	0	0.001855	0	0
VARS	7407	broad.mit.edu	37	6	31752254	31752254	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr6:31752254C>T	uc003nxe.2	-	12	1916	c.1493G>A	c.(1492-1494)CGC>CAC	p.R498H	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	498					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GAGCAGGGTGCGACCTGTCAG	0.597			NA											4	201					0	0	0.000602	0	0
RUNX2	860	broad.mit.edu	37	6	45459812	45459812	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr6:45459812C>T	uc011dvx.1	+	6	1030	c.820C>T	c.(820-822)CCA>TCA	p.P274S	RUNX2_uc011dvy.1_Missense_Mutation_p.P274S|RUNX2_uc003oxt.2_Missense_Mutation_p.P260S	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	274	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						GAACTCTGCACCAAGTCCTTT	0.532			NA											4	134					0	0	0.009096	0	0
PKHD1	5314	broad.mit.edu	37	6	51720762	51720762	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr6:51720762T>C	uc003pah.1	-	49	8116	c.7840A>G	c.(7840-7842)ATG>GTG	p.M2614V	PKHD1_uc010jzn.1_Missense_Mutation_p.M597V|PKHD1_uc003pai.2_Missense_Mutation_p.M2614V	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2614	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AGCAGAGCCATCCAGCCACGA	0.423			NA											17	104					0	0	0.008361	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62688017	62688017	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr6:62688017G>A	uc003peg.2	-	4	684	c.437C>T	c.(436-438)TCA>TTA	p.S146L		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		ACTCATACGTGAATAAGCTTC	0.368			NA											10	85					0	0	0.008291	0	0
MAD1L1	8379	broad.mit.edu	37	7	2108903	2108903	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:2108903C>T	uc003slh.1	-	12	1410	c.1144G>A	c.(1144-1146)GAG>AAG	p.E382K	MAD1L1_uc003sle.1_Missense_Mutation_p.E111K|MAD1L1_uc003slf.1_Missense_Mutation_p.E382K|MAD1L1_uc003slg.1_Missense_Mutation_p.E382K|MAD1L1_uc010ksh.1_Missense_Mutation_p.E382K|MAD1L1_uc003sli.1_Missense_Mutation_p.E290K|MAD1L1_uc010ksi.1_Missense_Mutation_p.E335K|MAD1L1_uc010ksj.2_Missense_Mutation_p.E382K	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	382	Necessary for interaction with NEK2.|Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TTCCTCTCCTCCAACAGCTGG	0.637			NA											6	102					0	0	0.006214	0	0
HECW1	23072	broad.mit.edu	37	7	43548608	43548608	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:43548608C>T	uc003tid.1	+	24	4512	c.3907C>T	c.(3907-3909)CTG>TTG	p.L1303L	HECW1_uc011kbi.1_Silent_p.L1269L|uc003tig.1_RNA	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1303	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTTCTTCCTTCTGTCTCAGGA	0.527			NA											16	307					0	0	0.003163	0	0
PKD1L1	168507	broad.mit.edu	37	7	47979820	47979820	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:47979820C>T	uc003tny.1	-	3	255	c.255G>A	c.(253-255)CAG>CAA	p.Q85Q		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	85	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AGGATGGGCTCTGTGATTCCC	0.468			NA											4	230					0	0	0.000602	0	0
ACN9	57001	broad.mit.edu	37	7	96810322	96810322	+	Splice_Site	SNP	A	A	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:96810322A>G	uc003uoo.3	+	2	1306	c.175_splice	c.e2-2	p.V59_splice		NM_020186	NP_064571	Q9NRP4	ACN9_HUMAN	ACN9 homolog precursor						regulation of gluconeogenesis	mitochondrial intermembrane space					0	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					TTATCTTTTTAGGTGTATGCA	0.328			NA											5	31					0	0	0.00308	0	0
SLC12A9	56996	broad.mit.edu	37	7	100459452	100459452	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:100459452G>C	uc003uwp.2	+	12	1772	c.1630G>C	c.(1630-1632)GCC>CCC	p.A544P	SLC12A9_uc003uwq.2_Missense_Mutation_p.A455P|SLC12A9_uc011kki.1_Missense_Mutation_p.A75P|SLC12A9_uc003uwr.2_Missense_Mutation_p.A280P|SLC12A9_uc003uws.2_Missense_Mutation_p.A75P|SLC12A9_uc003uwt.2_Missense_Mutation_p.A280P|SLC12A9_uc003uwv.2_Missense_Mutation_p.A75P	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	544	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCCCCGGGGCGCCCTGCCTCT	0.657			NA											8	43					0	0	0.014323	0	0
MUC17	140453	broad.mit.edu	37	7	100682517	100682517	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:100682517C>T	uc003uxp.1	+	3	7873	c.7820C>T	c.(7819-7821)ACT>ATT	p.T2607I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2607	Extracellular (Potential).|59 X approximate tandem repeats.|42.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTCACCACTTCTACTGAA	0.443			NA											74	404					0	0	0.01441	0	0
CLDN15	24146	broad.mit.edu	37	7	100877591	100877591	+	Missense_Mutation	SNP	G	G	A	rs80277788		TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:100877591G>A	uc003uyg.1	-	2	604	c.350C>T	c.(349-351)GCG>GTG	p.A117V	CLDN15_uc003uyh.1_Missense_Mutation_p.A117V|CLDN15_uc003uyi.2_3'UTR	NM_014343	NP_055158	P56746	CLD15_HUMAN	claudin 15	117	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					TGCGGTGGCCGCCAGCTTGGC	0.657			NA											46	110					0	0	0.01441	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121636514	121636514	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:121636514G>C	uc003vjy.2	+	9	1402	c.1007G>C	c.(1006-1008)CGA>CCA	p.R336P	PTPRZ1_uc003vjz.2_Missense_Mutation_p.R336P	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	336	Extracellular (Potential).|Fibronectin type-III.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GAAAGACCTCGAGTCGTTTAT	0.408			NA											4	138					0	0	0.009096	0	0
RNF133	168433	broad.mit.edu	37	7	122338652	122338653	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:122338652_122338653CC>AG	uc003vkj.1	-	1	556_557	c.320_321GG>CT	c.(319-321)CGG>CCT	p.R107P	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	107	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						TACAACCTCCCCGTTCAATAAG	0.455	Colon(198;1778 2057 7449 19869 45985)		NA											22	247					0	0	0.004672	0	0
MEST	4232	broad.mit.edu	37	7	130143804	130143804	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:130143804T>G	uc003vqg.2	+	11	1074	c.857T>G	c.(856-858)GTA>GGA	p.V286G	MEST_uc003vqc.2_Missense_Mutation_p.V277G|MEST_uc003vqd.2_Missense_Mutation_p.V243G|MEST_uc003vqf.2_Missense_Mutation_p.V277G|MEST_uc011kph.1_Missense_Mutation_p.V272G|MEST_uc010lmg.2_Intron	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	286	Helical; (Potential).				mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					TTGGATCCTGTAAATCCCTAT	0.398	Colon(126;2182 2305 6517 35181)		NA											14	177					0	0	0.00499	0	0
CNOT4	4850	broad.mit.edu	37	7	135098287	135098287	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:135098287G>A	uc003vsv.1	-	6	944	c.637C>T	c.(637-639)CTT>TTT	p.L213F	CNOT4_uc003vss.2_Missense_Mutation_p.L213F|CNOT4_uc011kpz.1_Missense_Mutation_p.L213F|CNOT4_uc003vst.2_Missense_Mutation_p.L213F|CNOT4_uc003vsu.1_Missense_Mutation_p.L213F|CNOT4_uc011kpy.1_Missense_Mutation_p.L213F	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	213	C3H1-type.				nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						AATTCATGAAGATACATGCAG	0.418	Ovarian(51;766 1130 5502 35047 50875)		NA											5	80					0	0	0.001168	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602619	138602619	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:138602619C>G	uc011kql.1	-	2	1802	c.1753G>C	c.(1753-1755)GAC>CAC	p.D585H	KIAA1549_uc003vuk.3_Missense_Mutation_p.D535H|KIAA1549_uc011kqj.1_Missense_Mutation_p.D585H	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	585	Ser-rich.					integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						ACACTCGGGTCTCTGACGGCA	0.468	NSCLC(119;1534 1718 44213 46230 50068)		NA	O	BRAF	pilocytic astrocytoma								4	25					0	0	0.000602	0	0
CLCN1	1180	broad.mit.edu	37	7	143027907	143027907	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:143027907T>G	uc003wcr.1	+	8	983	c.896T>G	c.(895-897)GTT>GGT	p.V299G	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_RNA|CLCN1_uc010loy.1_Missense_Mutation_p.F95V	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	299					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TACTTTGCTGTTCGGAACTAC	0.552			NA											40	78					0	0	0.00874	0	0
PTK2B	2185	broad.mit.edu	37	8	27287917	27287917	+	Silent	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:27287917G>A	uc003xfn.1	+	12	1459	c.651G>A	c.(649-651)CAG>CAA	p.Q217Q	PTK2B_uc003xfo.1_Silent_p.Q217Q|PTK2B_uc003xfp.1_Silent_p.Q217Q|PTK2B_uc003xfq.1_Silent_p.Q217Q|PTK2B_uc010luq.1_5'Flank|PTK2B_uc003xfr.1_5'Flank	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	217	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TCCCAAAGCAGATGCAGGAGA	0.552			NA											13	114					0	0	0.00499	0	0
TTPA	7274	broad.mit.edu	37	8	63978592	63978592	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:63978592C>G	uc003xux.1	-	3	455	c.423G>C	c.(421-423)GAG>GAC	p.E141D		NM_000370	NP_000361	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	141	CRAL-TRIO.		E -> K (in AVED).		lipid metabolic process		transporter activity|vitamin E binding				0	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	GTACAATAAGCTCGGATGTGA	0.393			NA											28	36					0	0	0.005443	0	0
UBR5	51366	broad.mit.edu	37	8	103291157	103291157	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:103291157C>G	uc003ykr.1	-	44	6218	c.6185G>C	c.(6184-6186)AGA>ACA	p.R2062T	UBR5_uc003yks.1_Missense_Mutation_p.R2062T	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2062					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATCCTCCTTTCTAGCATTTGG	0.348	Ovarian(131;96 1741 5634 7352 27489)		NA											13	221					0	0	0.013537	0	0
CSMD3	114788	broad.mit.edu	37	8	113694818	113694818	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:113694818G>A	uc003ynu.2	-	16	2689	c.2530C>T	c.(2530-2532)CGG>TGG	p.R844W	CSMD3_uc003yns.2_Missense_Mutation_p.R116W|CSMD3_uc003ynt.2_Missense_Mutation_p.R804W|CSMD3_uc011lhx.1_Missense_Mutation_p.R740W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	844	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCAAACCGCCGTGCATTGATT	0.348			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	151					0	0	0.00333	0	0
DEPDC6	64798	broad.mit.edu	37	8	121019082	121019082	+	Missense_Mutation	SNP	C	C	T	rs141805893		TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:121019082C>T	uc003yow.3	+	7	1151	c.964C>T	c.(964-966)CCC>TCC	p.P322S	DEPDC6_uc011lid.1_Missense_Mutation_p.P221S	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	322					intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ACTCCTTACTCCCGGGGCTCC	0.512			NA											4	76					0	0	0.000602	0	0
WDR67	93594	broad.mit.edu	37	8	124089411	124089411	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:124089411G>C	uc003ypp.1	+	2	228	c.138G>C	c.(136-138)TTG>TTC	p.L46F	WDR67_uc011lig.1_Missense_Mutation_p.L46F|WDR67_uc011lih.1_5'UTR|WDR67_uc003ypq.1_RNA|WDR67_uc003ypo.1_Missense_Mutation_p.L46F	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	46	WD 1.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TGCGATTTTTGAATGTGGCTT	0.373			NA											20	256					0	0	0.007413	0	0
PYCRL	65263	broad.mit.edu	37	8	144689207	144689207	+	Silent	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:144689207G>C	uc003yyy.2	-	3	298	c.288C>G	c.(286-288)GTC>GTG	p.V96V	PYCRL_uc011lkm.1_Silent_p.V96V|PYCRL_uc011lkn.1_RNA	NM_023078	NP_075566	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	84					proline biosynthetic process		pyrroline-5-carboxylate reductase activity				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CCTCTGCCAGGACAGCTGGCA	0.627			NA											9	93					0	0	0.001855	0	0
TDRD7	23424	broad.mit.edu	37	9	100258036	100258036	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr9:100258036C>T	uc004axj.2	+	17	3393	c.3168C>T	c.(3166-3168)GTC>GTT	p.V1056V	TDRD7_uc011lux.1_Silent_p.V982V|TDRD7_uc011luy.1_Silent_p.V376V	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	1056	Interacts with CDK17 (By similarity).|Interacts with CABLES1 (By similarity).				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				TGCAGACAGTCATTGAAAATG	0.478			NA											23	154					0	0	0.014323	0	0
NUP214	8021	broad.mit.edu	37	9	134003067	134003067	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr9:134003067C>T	uc004cag.2	+	2	313	c.202C>T	c.(202-204)CTT>TTT	p.L68F	NUP214_uc004cah.2_Missense_Mutation_p.L68F|NUP214_uc004caf.1_Missense_Mutation_p.L68F	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	68					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TAAAAATCTTCTTATTCAAAA	0.448	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								5	138					0	0	0.000602	0	0
TLR7	51284	broad.mit.edu	37	X	12905246	12905246	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:12905246C>A	uc004cvc.2	+	3	1758	c.1619C>A	c.(1618-1620)CCT>CAT	p.P540H		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	540	Extracellular (Potential).|LRR 17.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	GAATTCCAACCTTTAGCAGAG	0.398			NA											153	378					1.42561e-87	1.62927e-87	0.01441	1	0
TLR8	51311	broad.mit.edu	37	X	12937571	12937571	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:12937571C>T	uc004cve.2	+	2	480	c.412C>T	c.(412-414)CCC>TCC	p.P138S	TLR8_uc004cvd.2_Missense_Mutation_p.P156S	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	138	LRR 1.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CAACCAGTTACCCCAAATACC	0.388			NA											50	175					0	0	0.01441	0	0
CACNA1F	778	broad.mit.edu	37	X	49068406	49068406	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:49068406C>T	uc004dnb.2	-	35	4147	c.4085G>A	c.(4084-4086)CGA>CAA	p.R1362Q	CACNA1F_uc010nip.2_Missense_Mutation_p.R1351Q	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1362	Extracellular (Potential).|IV.				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GTTGTTGTTTCGGTTTATCTG	0.552			NA											21	151					0	0	0.00333	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003459	75003459	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:75003459G>C	uc004ecj.1	-	1	1613	c.1428C>G	c.(1426-1428)ATC>ATG	p.I476M		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	476	MAGE 2.									ovary(1)|skin(1)	2						CTTTCATTTTGATGGTTTCAT	0.493			NA											14	151					0	0	0.001855	0	0
GPRASP1	9737	broad.mit.edu	37	X	101909157	101909157	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:101909157T>A	uc004ejj.3	+	5	1117	c.316T>A	c.(316-318)TCT>ACT	p.S106T	GPRASP1_uc004eji.3_Missense_Mutation_p.S106T|GPRASP1_uc010nod.2_Missense_Mutation_p.S106T	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	106						cytoplasm	protein binding			ovary(1)|lung(1)	2						TGAAAGATTGTCTAAGACAGA	0.473			NA											105	282					0	0	0.01441	0	0
NUP62CL	54830	broad.mit.edu	37	X	106391025	106391025	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:106391025G>T	uc004ena.2	-	8	804	c.545C>A	c.(544-546)GCA>GAA	p.A182E	NUP62CL_uc004enb.2_RNA	NM_017681	NP_060151	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	182					protein transport	nuclear pore	structural constituent of nuclear pore				0						TCAGAATTCTGCAGATCTGGT	0.358			NA											18	54					2.54575e-18	2.87896e-18	0.010504	1	0
CAPN6	827	broad.mit.edu	37	X	110494845	110494845	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:110494845C>T	uc004epc.1	-	6	993	c.825G>A	c.(823-825)GAG>GAA	p.E275E	CAPN6_uc011msu.1_Silent_p.E20E	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	275	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						TATACACCTTCTCAGCACTGA	0.473			NA											61	667					0	0	0.01441	0	0
CUL4B	8450	broad.mit.edu	37	X	119660694	119660694	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:119660694C>G	uc004esw.2	-	22	3101	c.2664G>C	c.(2662-2664)AAG>AAC	p.K888N	CUL4B_uc010nqq.2_Missense_Mutation_p.K589N|CUL4B_uc004esv.2_Missense_Mutation_p.K870N	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	888					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						ATTCTATTCTCTTCTTAAGAT	0.353			NA											3	126					0	0	0.004672	0	0
TMEM185A	84548	broad.mit.edu	37	X	148692995	148692995	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:148692995C>T	uc011mxq.1	-	3	501	c.190G>A	c.(190-192)GTC>ATC	p.V64I	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|TMEM185A_uc011mxp.1_Intron|TMEM185A_uc004fdo.2_Intron|TMEM185A_uc004fdp.3_5'Flank	NM_032508	NP_115897	Q8NFB2	T185A_HUMAN	transmembrane protein 185A	64						integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CGTGCCCAGACTCCAGTTCCA	0.438			NA											6	598					0	0	0.001168	0	0
TKTL1	8277	broad.mit.edu	37	X	153539356	153539356	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:153539356C>G	uc004fkg.2	+	4	706	c.520C>G	c.(520-522)CAG>GAG	p.Q174E	TKTL1_uc011mzl.1_Missense_Mutation_p.Q168E|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Missense_Mutation_p.Q118E	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	174					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAACATCTATCAGAGGCGCTG	0.507			NA											14	131					0	0	0.00245	0	0
ATP6AP1	537	broad.mit.edu	37	X	153664138	153664138	+	Silent	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:153664138C>T	uc004flf.1	+	10	1375	c.1314C>T	c.(1312-1314)TTC>TTT	p.F438F	ATP6AP1_uc004flg.1_RNA|ATP6AP1_uc004flh.1_Silent_p.F398F|GDI1_uc011mzo.1_5'Flank|GDI1_uc004fli.3_5'Flank	NM_001183	NP_001174	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory	438	Helical; (Potential).				ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(3)|breast(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCATGCTCTTCATCTTCACCT	0.547			NA											9	618					0	0	0.004482	0	0
GAB3	139716	broad.mit.edu	37	X	153944516	153944516	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chrX:153944516C>T	uc004fmj.1	-	2	209	c.161G>A	c.(160-162)AGC>AAC	p.S54N	GAB3_uc004fmk.1_Missense_Mutation_p.S54N|GAB3_uc010nve.1_Missense_Mutation_p.S54N|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	54	PH.									ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GATGGGCTTGCTGGAGTGCTT	0.562			NA											8	176					0	0	0.006214	0	0
ETV6	2120	broad.mit.edu	37	12	12037505	12037506	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr12:12037505_12037506delTG	uc001qzz.2	+	6	1410_1411	c.1136_1137delTG	c.(1135-1137)CTGfs	p.L379fs	ETV6_uc001raa.1_Intron	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	379	ETS.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CTGGCTCGACTGTGGGGAAACC	0.46			NA	T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								9	157	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578397	7578412	+	Frame_Shift_Del	DEL	TGGGGGCAGCGCCTCA	TGGGGGCAGCGCCTCA	-	rs68130327		TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	TGGGGGCAGCGCCTCA	TGGGGGCAGCGCCTCA	-	-	TGGGGGCAGCGCCTCA	TGGGGGCAGCGCCTCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr17:7578397_7578412delTGGGGGCAGCGCCTCA	uc002gim.2	-	5	712_727	c.518_533delTGAGGCGCTGCCCCCA	c.(517-534)GTGAGGCGCTGCCCCCACfs	p.V173fs	TP53_uc002gig.1_Frame_Shift_Del_p.V173fs|TP53_uc002gih.2_Frame_Shift_Del_p.V173fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.V41fs|TP53_uc010cng.1_Frame_Shift_Del_p.V41fs|TP53_uc002gii.1_Frame_Shift_Del_p.V41fs|TP53_uc010cnh.1_Frame_Shift_Del_p.V173fs|TP53_uc010cni.1_Frame_Shift_Del_p.V173fs|TP53_uc002gij.2_Frame_Shift_Del_p.V173fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.V80fs|TP53_uc002gio.2_Frame_Shift_Del_p.V41fs|TP53_uc010vug.1_Frame_Shift_Del_p.V134fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173_178	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> L (in a sporadic cancer; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> HPHP (in a Burkitt lymphoma).|H -> D (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.C176F(102)|p.C176Y(55)|p.V173L(50)|p.V173M(39)|p.R175L(19)|p.C176S(18)|p.P177L(17)|p.P177R(15)|p.H178fs*69(13)|p.R175C(12)|p.C176W(11)|p.R175G(11)|p.P177P(10)|p.C176R(8)|p.H178Y(8)|p.P177_C182delPHHERC(8)|p.P177S(8)|p.V173A(8)|p.V173V(8)|p.R174W(8)|p.C176fs*71(7)|p.0?(7)|p.H178P(6)|p.C176*(6)|p.V173G(6)|p.H178fs*3(5)|p.R175S(5)|p.R43H(5)|p.R175P(5)|p.R82H(5)|p.R174fs*73(4)|p.H178D(4)|p.R175R(4)|p.V173fs*1(4)|p.R174K(4)|p.C176_R181delCPHHER(3)|p.C176G(3)|p.H178N(3)|p.P177H(3)|p.R175_E180delRCPHHE(3)|p.R174fs*24(3)|p.C176fs*5(3)|p.R174fs*1(2)|p.R175fs*5(2)|p.P177fs*3(2)|p.R174S(2)|p.V173fs*59(2)|p.R174R(2)|p.R174M(2)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.R175_H178>X(1)|p.V173fs*8(1)|p.C83Y(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.H178L(1)|p.R174fs*3(1)|p.R174fs*7(1)|p.V157_C176del20(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175fs*6(1)|p.P177fs*4(1)|p.H168fs*69(1)|p.C176del(1)|p.S149fs*72(1)|p.P177I(1)|p.P177T(1)|p.K164_P219del(1)|p.H178del(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.H179del(1)|p.V173E(1)|p.P177fs*69(1)|p.V173W(1)|p.R42fs*24(1)|p.R175fs*72(1)|p.R174_E180>K(1)|p.P177_E180delPHHE(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.C176fs*68(1)|p.P151_V173del23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.R174G(1)|p.R81fs*24(1)|p.C176fs*6(1)|p.P177_H179delPHH(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCTCATGGTGGGGGCAGCGCCTCACAACCTCCGT	0.644	Pancreas(47;798 1329 9957 10801)	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	43	---	---	---	---	NA	NA	NA	NA	NA
UBA6	55236	broad.mit.edu	37	4	68484822	68484822	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr4:68484822delC	uc003hdg.3	-	33	3104	c.3052delG	c.(3052-3054)GAAfs	p.E1018fs		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	1018					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TATTTCTTTTCAGTAGTAGGT	0.338			NA											10	112	---	---	---	---	NA	NA	NA	NA	NA
APC	324	broad.mit.edu	37	5	112175532	112175533	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr5:112175532_112175533insA	uc010jby.2	+	16	4621_4622	c.4241_4242insA	c.(4240-4242)GTAfs	p.V1414fs	APC_uc011cvt.1_Frame_Shift_Ins_p.V1396fs|APC_uc003kpz.3_Frame_Shift_Ins_p.V1414fs|APC_uc003kpy.3_Frame_Shift_Ins_p.V1414fs|APC_uc010jbz.2_Frame_Shift_Ins_p.V1131fs|APC_uc010jca.2_Frame_Shift_Ins_p.V714fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1414	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.V1414fs*1(8)|p.V1414fs*9(6)|p.S1415fs*8(2)|p.V1414I(1)|p.Y1376fs*41(1)|p.?(1)|p.S1411fs*41(1)|p.M1413fs*5(1)|p.P1409fs*6(1)|p.K1192fs*3(1)|p.V1414fs*5(1)|p.S1415fs*4(1)|p.V1414fs*3(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AGTGGAATGGTAAGTGGCATTA	0.47	NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			13	82	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55242480	55242503	+	In_Frame_Del	DEL	AACATCTCCGAAAGCCAACAAGGA	AACATCTCCGAAAGCCAACAAGGA	-	rs121913463		TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	AACATCTCCGAAAGCCAACAAGGA	AACATCTCCGAAAGCCAACAAGGA	-	-	AACATCTCCGAAAGCCAACAAGGA	AACATCTCCGAAAGCCAACAAGGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr7:55242480_55242503delAACATCTCCGAAAGCCAACAAGGA	uc003tqk.2	+	19	2496_2519	c.2250_2273delAACATCTCCGAAAGCCAACAAGGA	c.(2248-2274)GCAACATCTCCGAAAGCCAACAAGGAA>GCA	p.TSPKANKE751del	EGFR_uc010kzg.1_In_Frame_Del_p.TSPKANKE706del|EGFR_uc011kco.1_In_Frame_Del_p.TSPKANKE698del	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	751_758	Cytoplasmic (Potential).|Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(313)|p.L747_P753>S(166)|p.L747_T751del(114)|p.E746_S752>V(67)|p.L747_S752del(64)|p.L747_T751>P(33)|p.E746_T751>A(30)|p.L747_P753del(21)|p.L747_P753>Q(19)|p.E746_T751del(18)|p.L747_T751>S(12)|p.S752_I759del(12)|p.E746_S752del(10)|p.T751_I759>N(8)|p.L747_T751>Q(7)|p.E746_P753>VS(6)|p.E746_T751>I(5)|p.E746_T751>V(5)|p.E746_S752>A(5)|p.E746_T751>IP(5)|p.T751I(5)|p.S752P(4)|p.E746_S752>D(4)|p.T751_I759>S(3)|p.A750_E758>P(3)|p.L747_S752>Q(3)|p.E746_T751>VA(3)|p.P753S(3)|p.E746_T751>VP(3)|p.L747_S752>QH(2)|p.E746_T751>L(2)|p.A750_K757del(2)|p.L747_T751>A(2)|p.E746_T751>Q(2)|p.E746_T751>S(2)|p.E746_S752>T(2)|p.A750_E758del(2)|p.E746_P753del(2)|p.E746_S752>I(2)|p.T751_I759>NKA(2)|p.E749_E758>QP(2)|p.T751_E758del(2)|p.L747_K754>ST(1)|p.A750_K754del(1)|p.L747_S752>QR(1)|p.K754E(1)|p.P753P(1)|p.L747_K754>GC(1)|p.E746_A750>VP(1)|p.L747_K754>N(1)|p.L747_A755del(1)|p.P753_I759del(1)|p.A755A(1)|p.L747_S752>V(1)|p.R748_S752del(1)|p.K757>NK(1)|p.K754K(1)|p.L747_T751>F(1)|p.E749_P753>Q(1)|p.T751_E758>A(1)|p.R748_P753del(1)|p.E746_P753>VQ(1)|p.L747_P753>CG(1)|p.E746_T751>LS(1)|p.L747_T751>N(1)|p.L747_A755>SKS(1)|p.E746_T751>P(1)|p.L747_K754del(1)|p.L747_N756>SKDD(1)|p.S752Y(1)|p.N756Y(1)|p.K754A(1)|p.T751_I759>REA(1)|p.N756S(1)|p.E746_P753>LS(1)|p.K757M(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGAT	0.496		L747_P753>Q(HCC4006_LUNG)|P753S(SKMEL28_SKIN)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			31	147	---	---	---	---	NA	NA	NA	NA	NA
OSGIN2	734	broad.mit.edu	37	8	90937445	90937445	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4402-01A-01D-1265-08	TCGA-05-4402-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75475a84-582d-4949-a428-1e28ad526d8c	7ea934db-e2a4-4530-9a26-5912ac7d34a2	g.chr8:90937445delG	uc003yeg.2	+	6	1549	c.1203delG	c.(1201-1203)AAGfs	p.K401fs	OSGIN2_uc003yeh.2_Frame_Shift_Del_p.K445fs	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	401					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			CTGGATTGAAGAAAATATTTA	0.408			NA											22	186	---	---	---	---	NA	NA	NA	NA	NA