Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NPHP4	261734	broad.mit.edu	37	1	5925161	5925161	+	Splice_Site	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:5925161C>A	uc001alq.1	-	27	4082	c.3816_splice	c.e27+1	p.K1272_splice	NPHP4_uc001alr.1_3'UTR	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin						actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGGCCGTACCTTCAGCTCC	0.637			NA											4	31					5.9392e-07	7.13212e-07	0.001168	1	0
KAZ	23254	broad.mit.edu	37	1	14925597	14925597	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:14925597G>A	uc001avm.3	+	1	385	c.104G>A	c.(103-105)CGG>CAG	p.R35Q	KAZ_uc009vog.1_Missense_Mutation_p.R35Q|KAZ_uc010obj.1_Missense_Mutation_p.R35Q	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	35					keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						GCCACCAACCGGAGACTGGCG	0.448			NA											3	51					0	0	0.004672	0	0
HTR6	3362	broad.mit.edu	37	1	19992913	19992913	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:19992913G>T	uc001bcl.2	+	1	1134	c.667G>T	c.(667-669)GCC>TCC	p.A223S		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	223	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CGTGCAGGTGGCCTCCCTCAC	0.657	Esophageal Squamous(168;1879 2619 6848 21062)		NA											12	25					6.42651e-13	8.76626e-13	0.010729	1	0
COL24A1	255631	broad.mit.edu	37	1	86590968	86590968	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:86590968C>A	uc001dlj.2	-	3	1093	c.1051G>T	c.(1051-1053)GTG>TTG	p.V351L	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.V351L	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	351					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TGAGTGGTCACTGACAGGCTG	0.413			NA											46	48					3.77016e-25	6.30604e-25	0.013114	1	0
GBP4	115361	broad.mit.edu	37	1	89658733	89658733	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:89658733G>T	uc001dnb.2	-	5	640	c.524C>A	c.(523-525)CCT>CAT	p.P175H		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	175						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		AGCTTCATCAGGTCTGGGGCA	0.478			NA											22	71					2.89027e-11	3.79516e-11	0.002299	1	0
PDE4DIP	9659	broad.mit.edu	37	1	145075718	145075718	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:145075718G>A	uc001emh.2	-	1	362	c.145C>T	c.(145-147)CGG>TGG	p.R49W	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Missense_Mutation_p.R49W|PDE4DIP_uc001emk.2_Missense_Mutation_p.R49W	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	723					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGTCTTTCCCGGCTCGGGGTC	0.716			NA	T	PDGFRB	MPD								36	108					0	0	0.003755	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244			NA											8	115					0	0	0.00308	0	0
HRNR	388697	broad.mit.edu	37	1	152187539	152187540	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:152187539_152187540CC>AT	uc001ezt.1	-	3	6641_6642	c.6565_6566GG>AT	c.(6565-6567)GGG>ATG	p.G2189M		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2189	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGAACCGGACCCATGTCGGCCG	0.644			NA											11	406					0	0	0.004672	0	0
ASH1L	55870	broad.mit.edu	37	1	155449990	155449990	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:155449990C>T	uc009wqq.2	-	3	3151	c.2671G>A	c.(2671-2673)GGC>AGC	p.G891S	ASH1L_uc001fkt.2_Missense_Mutation_p.G891S|ASH1L_uc009wqr.1_Missense_Mutation_p.G891S	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	891	A.T hook 1.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTAGGCCTGCCTCTCTTTTTT	0.453			NA											135	78					0	0	0.00361	0	0
OR10X1	128367	broad.mit.edu	37	1	158549146	158549146	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:158549146C>A	uc010pin.1	-	1	544	c.544G>T	c.(544-546)GAC>TAC	p.D182Y		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CAGAAAGAGTCCCTGAATATC	0.438			NA											51	38					1.81118e-26	3.12235e-26	0.00361	1	0
OR10J3	441911	broad.mit.edu	37	1	159283997	159283997	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:159283997C>A	uc010piu.1	-	1	453	c.453G>T	c.(451-453)GGG>GGT	p.G151G		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					CAAGGCCAATCCCCAGTGATC	0.512			NA											55	36					3.13117e-07	3.82547e-07	0.00361	1	0
ATP1A4	480	broad.mit.edu	37	1	160124868	160124868	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:160124868A>T	uc001fve.3	+	3	720	c.241A>T	c.(241-243)ACT>TCT	p.T81S	ATP1A4_uc001fvf.3_RNA	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	81	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGAAATCCTGACTCGAGGTGG	0.507			NA											30	201					0	0	0.009535	0	0
TNN	63923	broad.mit.edu	37	1	175092666	175092666	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:175092666G>T	uc001gkl.1	+	12	2894	c.2781G>T	c.(2779-2781)AGG>AGT	p.R927S		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	927	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GAGAGACCAGGGAGGTTCCGG	0.622			NA											61	27					1.74971e-23	2.85854e-23	0.00361	1	0
PAPPA2	60676	broad.mit.edu	37	1	176564316	176564316	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:176564316C>T	uc001gkz.2	+	3	2740	c.1576C>T	c.(1576-1578)CGC>TGC	p.R526C	PAPPA2_uc001gky.1_Missense_Mutation_p.R526C|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	526	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAAGGTGATACGCTACCAGGT	0.537			NA											13	51					0	0	0.001368	0	0
CACNA1E	777	broad.mit.edu	37	1	181620507	181620507	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:181620507C>A	uc001gow.2	+	7	1150	c.985C>A	c.(985-987)CTG>ATG	p.L329M	CACNA1E_uc009wxr.2_Missense_Mutation_p.L236M|CACNA1E_uc009wxs.2_Missense_Mutation_p.L236M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	329	I.|Helical; Name=S6 of repeat I.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CTGGAATTGGCTGTACTTCAT	0.428			NA											135	74					1.26737e-53	2.61861e-53	0.00361	1	0
HMCN1	83872	broad.mit.edu	37	1	186026523	186026523	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:186026523G>T	uc001grq.1	+	46	7531	c.7302G>T	c.(7300-7302)AGG>AGT	p.R2434S		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2434	Ig-like C2-type 22.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATTCTGTGAGGATTCTTTCAG	0.393			NA											61	46					1.84395e-34	3.47752e-34	0.00361	1	0
OCLM	10896	broad.mit.edu	37	1	186370265	186370265	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:186370265G>T	uc001gry.2	+	1	562	c.88G>T	c.(88-90)GGT>TGT	p.G30C	C1orf27_uc001grw.2_Intron|C1orf27_uc010poq.1_Intron|C1orf27_uc010por.1_Intron	NM_022375	NP_071770	Q9Y5M6	TISR_HUMAN	oculomedin	30					visual perception						0						TTATAAAAGTGGTATTATATG	0.318			NA											21	107					2.39187e-15	3.50601e-15	0.008871	1	0
FAM5C	339479	broad.mit.edu	37	1	190067405	190067405	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:190067405C>G	uc001gse.1	-	8	2276	c.2044G>C	c.(2044-2046)GAC>CAC	p.D682H	FAM5C_uc010pot.1_Missense_Mutation_p.D580H	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	682						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AAAATCAGGTCCCGAATTGCT	0.458			NA											28	108					0	0	0.007291	0	0
TROVE2	6738	broad.mit.edu	37	1	193051691	193051691	+	Splice_Site	SNP	G	G	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:193051691G>C	uc001gss.2	+	8	1493	c.1318_splice	c.e8-1	p.I440_splice	TROVE2_uc001gst.1_Splice_Site_p.I165_splice|TROVE2_uc001gsu.1_Splice_Site_p.I165_splice|TROVE2_uc001gsv.1_Splice_Site_p.I440_splice|TROVE2_uc001gsw.2_Splice_Site_p.I440_splice|TROVE2_uc009wyp.2_Splice_Site_p.I440_splice|TROVE2_uc009wyq.2_Splice_Site_p.I440_splice|TROVE2_uc001gsx.1_Splice_Site_p.I440_splice	NM_004600	NP_004591	P10155	RO60_HUMAN	TROVE domain family, member 2 isoform 2						transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0						TTCCGAATTAGATCCCAGCAG	0.363			NA											40	21					0	0	0.005524	0	0
CRB1	23418	broad.mit.edu	37	1	197396716	197396716	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:197396716C>A	uc001gtz.2	+	7	2396	c.2261C>A	c.(2260-2262)GCT>GAT	p.A754D	CRB1_uc010poz.1_Missense_Mutation_p.A685D|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.A642D|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.A235D|CRB1_uc001gub.1_Missense_Mutation_p.A403D	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	754	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TTACTTCTAGCTTTGGAAAAC	0.438			NA											12	59					5.50884e-06	6.2168e-06	0.001368	1	0
ZP4	57829	broad.mit.edu	37	1	238048146	238048146	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:238048146A>T	uc001hym.2	-	10	1313	c.1313T>A	c.(1312-1314)GTG>GAG	p.V438E	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	438	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GTGCAGATGCACCTGGGAGCC	0.512	NSCLC(166;160 2029 11600 18754 19936)		NA											4	32					0	0	0.000602	0	0
OR2G3	81469	broad.mit.edu	37	1	247769300	247769300	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:247769300C>T	uc010pyz.1	+	1	413	c.413C>T	c.(412-414)CCA>CTA	p.P138L		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATCATGAACCCACGGCTTTGC	0.512			NA											147	97					0	0	0.00361	0	0
OR2T33	391195	broad.mit.edu	37	1	248436974	248436975	+	Missense_Mutation	DNP	TG	TG	GA	rs150221634	byFrequency	TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:248436974_248436975TG>GA	uc010pzi.1	-	1	142_143	c.142_143CA>TC	c.(142-144)CAC>TCC	p.H48S		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTGGTCCCAGTGAATCAGGAGA	0.52			NA											95	65					0	0	0.004672	0	0
KIAA1217	56243	broad.mit.edu	37	10	24832238	24832238	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr10:24832238C>G	uc001iru.3	+	19	4442	c.4039C>G	c.(4039-4041)CAA>GAA	p.Q1347E	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Missense_Mutation_p.Q1030E|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Missense_Mutation_p.Q183E	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1347					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AGATTTTGGCCAAGTTGTTCT	0.433			NA											50	84					0	0	0.00361	0	0
PCDH15	65217	broad.mit.edu	37	10	55755478	55755478	+	Silent	SNP	C	C	A	rs139853291	byFrequency	TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr10:55755478C>A	uc001jju.1	-	21	3194	c.2799G>T	c.(2797-2799)GGG>GGT	p.G933G	PCDH15_uc010qhq.1_Silent_p.G938G|PCDH15_uc010qhr.1_Silent_p.G933G|PCDH15_uc010qhs.1_Silent_p.G945G|PCDH15_uc010qht.1_Silent_p.G940G|PCDH15_uc010qhu.1_Silent_p.G933G|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.G933G|PCDH15_uc010qhw.1_Silent_p.G896G|PCDH15_uc010qhx.1_Silent_p.G862G|PCDH15_uc010qhy.1_Silent_p.G938G|PCDH15_uc010qhz.1_Silent_p.G933G|PCDH15_uc010qia.1_Silent_p.G911G|PCDH15_uc010qib.1_Silent_p.G911G|PCDH15_uc001jjw.2_Silent_p.G933G	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	933	Extracellular (Potential).|Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GAGCCACCATCCCTTTGTATA	0.393			NA								HNSCC(58;0.16)			25	30					8.24728e-16	1.23271e-15	0.004656	1	0
KCNMA1	3778	broad.mit.edu	37	10	78771774	78771774	+	Silent	SNP	A	A	G	rs146803262		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr10:78771774A>G	uc001jxn.2	-	18	2220	c.2043T>C	c.(2041-2043)CAT>CAC	p.H681H	KCNMA1_uc001jxj.2_Silent_p.H685H|KCNMA1_uc001jxk.1_Silent_p.H296H|KCNMA1_uc009xrt.1_Silent_p.H501H|KCNMA1_uc001jxl.1_Silent_p.H335H|KCNMA1_uc001jxo.2_Silent_p.H681H|KCNMA1_uc001jxm.2_Silent_p.H681H|KCNMA1_uc001jxq.2_Silent_p.H681H	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	681	Heme-binding motif.|Cytoplasmic (Potential).			H->R: Loss of heme-induced channel inhibition.	cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGATGTCATCATGACAGGCCT	0.428			NA											35	61					0	0	0.003755	0	0
CDHR1	92211	broad.mit.edu	37	10	85961609	85961609	+	Missense_Mutation	SNP	G	G	C	rs142631189		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr10:85961609G>C	uc001kcv.2	+	7	572	c.572G>C	c.(571-573)CGC>CCC	p.R191P	CDHR1_uc001kcw.2_Missense_Mutation_p.R191P|CDHR1_uc009xst.2_5'UTR	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	191	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						GGTGTGCTGCGCCTCCAGGCT	0.622			NA											11	22					0	0	0.010729	0	0
ATRNL1	26033	broad.mit.edu	37	10	117185778	117185778	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr10:117185778C>T	uc001lcg.2	+	21	3674	c.3288C>T	c.(3286-3288)CGC>CGT	p.R1096R	ATRNL1_uc010qsm.1_Silent_p.R225R|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1096	Laminin EGF-like 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CTGAAAATCGCTATGTTGGTA	0.284			NA											45	74					0	0	0.00361	0	0
DMBT1	1755	broad.mit.edu	37	10	124336238	124336238	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr10:124336238G>A	uc001lgk.1	+	7	713	c.607G>A	c.(607-609)GCT>ACT	p.A203T	DMBT1_uc001lgl.1_Missense_Mutation_p.A203T|DMBT1_uc001lgm.1_Missense_Mutation_p.A203T|DMBT1_uc009xzz.1_Missense_Mutation_p.A203T|DMBT1_uc010qtx.1_Missense_Mutation_p.A203T|DMBT1_uc009yaa.1_Missense_Mutation_p.A55T	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	203					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TATCTGCTCAGGTAGGCATCC	0.348	Ovarian(182;93 2026 18125 22222 38972)		NA											32	52					0	0	0.008361	0	0
OR51E2	81285	broad.mit.edu	37	11	4703755	4703755	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:4703755A>C	uc001lzk.2	-	2	431	c.187T>G	c.(187-189)TGC>GGC	p.C63G		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GCAAGCATGCAGAGAAAGAGG	0.507			NA											22	56					0	0	0.00278	0	0
OR51G2	81282	broad.mit.edu	37	11	4936863	4936863	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:4936863T>A	uc001lzr.1	-	1	31	c.31A>T	c.(31-33)AGC>TGC	p.S11C		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAAACGCTGCTGCTGCTGTTT	0.542			NA											17	47					0	0	0.006122	0	0
OR56A3	390083	broad.mit.edu	37	11	5968810	5968810	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:5968810C>A	uc010qzt.1	+	1	234	c.234C>A	c.(232-234)TGC>TGA	p.C78*		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	78	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGTGCTCTGCCTCACTGTCA	0.572			NA											78	127					1.15098e-32	2.11388e-32	0.00361	1	0
PTH	5741	broad.mit.edu	37	11	13514029	13514029	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:13514029C>A	uc001mlb.2	-	3	386	c.271G>T	c.(271-273)GTT>TTT	p.V91F		NM_000315	NP_000306	P01270	PTHY_HUMAN	parathyroid hormone preproprotein	91					bone resorption|cAMP metabolic process|cell-cell signaling|cellular calcium ion homeostasis|cellular macromolecule biosynthetic process|induction of apoptosis by hormones|positive regulation of cAMP biosynthetic process|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|skeletal system development		hormone activity|peptide hormone receptor binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(625;0.00116)|Epithelial(150;0.0357)|LUSC - Lung squamous cell carcinoma(625;0.0836)		TGGCTCTCAACCAAGACATTG	0.443			NA											36	133					3.76114e-14	5.36487e-14	0.004289	1	0
C11orf74	119710	broad.mit.edu	37	11	36669581	36669581	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:36669581C>G	uc001mwy.1	+	5	447	c.374C>G	c.(373-375)CCA>CGA	p.P125R	C11orf74_uc010rfd.1_RNA|C11orf74_uc001mww.1_Missense_Mutation_p.P51R|C11orf74_uc001mwx.1_RNA|C11orf74_uc001mwz.1_Missense_Mutation_p.P51R|C11orf74_uc010rfe.1_RNA	NM_138787	NP_620142	Q86VG3	CK074_HUMAN	hypothetical protein LOC119710	125											0	all_lung(20;0.226)	all_hematologic(20;0.0118)				CTGCTGCTTCCAGGAGAAGTG	0.443			NA											59	156					0	0	0.00361	0	0
C11orf74	119710	broad.mit.edu	37	11	36669586	36669586	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:36669586G>A	uc001mwy.1	+	5	452	c.379G>A	c.(379-381)GAA>AAA	p.E127K	C11orf74_uc010rfd.1_RNA|C11orf74_uc001mww.1_Missense_Mutation_p.E53K|C11orf74_uc001mwx.1_RNA|C11orf74_uc001mwz.1_Missense_Mutation_p.E53K|C11orf74_uc010rfe.1_RNA	NM_138787	NP_620142	Q86VG3	CK074_HUMAN	hypothetical protein LOC119710	127											0	all_lung(20;0.226)	all_hematologic(20;0.0118)				GCTTCCAGGAGAAGTGGAGCA	0.443			NA											59	157					0	0	0.00361	0	0
DGKZ	8525	broad.mit.edu	37	11	46388906	46388906	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:46388906G>T	uc001ncn.1	+	3	919	c.794G>T	c.(793-795)TGC>TTC	p.C265F	DGKZ_uc001nch.1_Missense_Mutation_p.C93F|DGKZ_uc010rgq.1_Missense_Mutation_p.C42F|DGKZ_uc001ncj.1_Missense_Mutation_p.C42F|DGKZ_uc010rgr.1_Missense_Mutation_p.C42F|DGKZ_uc001nck.1_5'UTR|DGKZ_uc001ncl.2_Missense_Mutation_p.C76F|DGKZ_uc001ncm.2_Missense_Mutation_p.C76F|DGKZ_uc009yky.1_Missense_Mutation_p.C76F|DGKZ_uc010rgs.1_Missense_Mutation_p.C76F|DGKZ_uc001nci.1_Missense_Mutation_p.C42F	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	265					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		GGGGCCCCGTGCAGCGAGTCA	0.672			NA											20	36					1.40151e-16	2.11733e-16	0.010504	1	0
OR5L2	26338	broad.mit.edu	37	11	55595361	55595361	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:55595361A>G	uc001nhy.1	+	1	667	c.667A>G	c.(667-669)ACC>GCC	p.T223A		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GCTAATTCTCACCACTATCCT	0.498			NA								HNSCC(27;0.073)			52	91					0	0	0.00361	0	0
SPRYD5	84767	broad.mit.edu	37	11	55653690	55653690	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:55653690G>T	uc010rip.1	+	3	595	c.503G>T	c.(502-504)TGG>TTG	p.W168L	SPRYD5_uc010riq.1_Missense_Mutation_p.W25L	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	168						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				ACCAGATGCTGGAAGGTTAGT	0.398			NA											30	41					8.4185e-14	1.1828e-13	0.012213	1	0
OR5W2	390148	broad.mit.edu	37	11	55681357	55681357	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:55681357C>A	uc010rir.1	-	1	702	c.702G>T	c.(700-702)AGG>AGT	p.R234S		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAGCTTTGAACCTCCCCTCAG	0.418	Melanoma(48;171 1190 15239 43886 49348)		NA											37	55					6.53348e-20	1.01995e-19	0.003755	1	0
B3GAT3	26229	broad.mit.edu	37	11	62384573	62384573	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:62384573G>T	uc001ntw.2	-	3	533	c.504C>A	c.(502-504)CTC>CTA	p.L168L	B3GAT3_uc009ynz.2_Silent_p.L161L|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Silent_p.L168L	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	168	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						CTCTGCCCCGGAGCCAGTCCA	0.662			NA											38	56					3.21399e-22	5.16076e-22	0.004878	1	0
SNX15	29907	broad.mit.edu	37	11	64806226	64806226	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:64806226G>A	uc001oci.3	+	10	1500	c.847G>A	c.(847-849)GAG>AAG	p.E283K	SNX15_uc009ypy.2_Missense_Mutation_p.E283K|SNX15_uc001ocj.2_Missense_Mutation_p.E283K|SNX15_uc001ock.2_Intron|SAC3D1_uc010rnv.1_5'Flank|SAC3D1_uc001ocm.2_5'Flank	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	283	MIT.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						CCTGCGGGATGAGAAGGCAGG	0.652	Esophageal Squamous(56;269 1304 3324 8253)		NA											9	9					0	0	0.004482	0	0
MTL5	9633	broad.mit.edu	37	11	68514791	68514791	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:68514791G>T	uc001ooc.2	-	3	655	c.515C>A	c.(514-516)CCG>CAG	p.P172Q	MTL5_uc001ood.1_Missense_Mutation_p.P172Q|MTL5_uc009ysi.1_Missense_Mutation_p.P172Q|MTL5_uc001ooe.2_Missense_Mutation_p.P172Q	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	172					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TGCTTCTTCCGGATTATTACT	0.423			NA											4	63					0.00909568	0.00983033	0.009096	1	0
FOLR3	2352	broad.mit.edu	37	11	71847143	71847143	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:71847143C>A	uc001ory.1	+	2	195	c.145C>A	c.(145-147)CCC>ACC	p.P49T	FOLR3_uc001orx.1_Missense_Mutation_p.P49T			P41439	FOLR3_HUMAN	SubName: Full=FOLR3 protein; Flags: Fragment;	47					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity				0					Folic Acid(DB00158)	ACAGCCCAGCCCCGAGGACGA	0.642			NA											62	114					5.98616e-33	1.11398e-32	0.00361	1	0
PPME1	51400	broad.mit.edu	37	11	73950231	73950231	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:73950231T>A	uc001ouw.2	+	9	863	c.764T>A	c.(763-765)ATA>AAA	p.I255K	PPME1_uc009yty.2_Missense_Mutation_p.I125K|PPME1_uc001oux.2_Missense_Mutation_p.I68K	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	255					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					GAAGGAATCATAGAGGAAGAA	0.368			NA											18	36					0	0	0.007413	0	0
ENDOD1	23052	broad.mit.edu	37	11	94861876	94861876	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:94861876A>T	uc001pfh.2	+	2	711	c.636A>T	c.(634-636)AAA>AAT	p.K212N		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	212						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				TTAAAGACAAAGTGGCAGTCC	0.557			NA											22	31					0	0	0.012319	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103091378	103091378	+	Silent	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:103091378A>T	uc001pho.2	+	57	9117	c.8973A>T	c.(8971-8973)GCA>GCT	p.A2991A	DYNC2H1_uc001phn.1_Silent_p.A2991A|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2991	Stalk (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTAAACTAGCAGTTGGAAACA	0.323			NA											64	91					0	0	0.00361	0	0
CASP5	838	broad.mit.edu	37	11	104879698	104879698	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:104879698C>T	uc010rva.1	-	2	49	c.17G>A	c.(16-18)GGC>GAC	p.G6D	CASP5_uc010ruz.1_Missense_Mutation_p.G19D|CASP5_uc010rvb.1_Intron|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_Intron|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	6					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TTTTTTTTTGCCACTGTCTTC	0.388			NA											15	39					0	0	0.006122	0	0
BLID	414899	broad.mit.edu	37	11	121986432	121986432	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr11:121986432G>T	uc001pyf.2	-	1	492	c.199C>A	c.(199-201)CTT>ATT	p.L67I	LOC399959_uc009zba.2_Intron	NM_001001786	NP_001001786	Q8IZY5	BLID_HUMAN	BRCC2 protein	67					apoptosis	mitochondrion					0		Breast(109;0.0164)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;2.08e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.101)		TACCTTTTAAGAGAAAGCACT	0.463			NA									OREG0021435	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	71	55					2.5377e-55	5.28217e-55	0.00361	1	0
CACNA1C	775	broad.mit.edu	37	12	2721098	2721098	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:2721098C>A	uc009zdu.1	+	30	4120	c.3807C>A	c.(3805-3807)ATC>ATA	p.I1269I	CACNA1C_uc009zdv.1_Silent_p.I1246I|CACNA1C_uc001qkb.2_Silent_p.I1249I|CACNA1C_uc001qkc.2_Silent_p.I1249I|CACNA1C_uc001qke.2_Silent_p.I1249I|CACNA1C_uc001qkf.2_Silent_p.I1249I|CACNA1C_uc001qjz.2_Silent_p.I1249I|CACNA1C_uc001qkd.2_Silent_p.I1249I|CACNA1C_uc001qkg.2_Silent_p.I1249I|CACNA1C_uc009zdw.1_Silent_p.I1249I|CACNA1C_uc001qkh.2_Silent_p.I1249I|CACNA1C_uc001qkl.2_Silent_p.I1269I|CACNA1C_uc001qkn.2_Silent_p.I1249I|CACNA1C_uc001qko.2_Silent_p.I1269I|CACNA1C_uc001qkp.2_Silent_p.I1249I|CACNA1C_uc001qkr.2_Silent_p.I1249I|CACNA1C_uc001qku.2_Silent_p.I1249I|CACNA1C_uc001qkq.2_Silent_p.I1249I|CACNA1C_uc001qks.2_Silent_p.I1249I|CACNA1C_uc001qkt.2_Silent_p.I1249I|CACNA1C_uc001qka.1_Silent_p.I784I|CACNA1C_uc001qki.1_Silent_p.I985I|CACNA1C_uc001qkj.1_Silent_p.I985I|CACNA1C_uc001qkk.1_Silent_p.I985I|CACNA1C_uc001qkm.1_Silent_p.I985I	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1269	IV.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGTTCAAAATCGCCATGAACA	0.562			NA											39	41					1.59361e-14	2.30827e-14	0.006999	1	0
VWF	7450	broad.mit.edu	37	12	6085306	6085306	+	Nonsense_Mutation	SNP	G	G	A	rs61751288		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:6085306G>A	uc001qnn.1	-	43	7658	c.7408C>T	c.(7408-7410)CAG>TAG	p.Q2470*	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2470	VWFC 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CAGGGCTTCTGGGAGCACTGG	0.637			NA											18	80					0	0	0.006122	0	0
VWF	7450	broad.mit.edu	37	12	6085325	6085325	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:6085325G>A	uc001qnn.1	-	43	7639	c.7389C>T	c.(7387-7389)CTC>CTT	p.L2463L	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2463	VWFC 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGGCCACGCGGAGGCCCATCA	0.642			NA											17	83					0	0	0.006122	0	0
SLC2A14	144195	broad.mit.edu	37	12	7984358	7984358	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:7984358G>T	uc001qtk.2	-	9	976	c.183C>A	c.(181-183)ATC>ATA	p.I61I	SLC2A14_uc001qtl.2_Silent_p.I38I|SLC2A14_uc001qtm.2_Silent_p.I38I|SLC2A14_uc010sgg.1_Intron|SLC2A14_uc001qtn.2_Silent_p.I61I|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Silent_p.I76I	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	61	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		ATTCCTTTATGATCTGCAAAA	0.333			NA									OREG0021654	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	58					3.52763e-06	4.06256e-06	0.00499	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			13	9					4.7546e-09	5.96448e-09	0.004007	1	0
TMTC1	83857	broad.mit.edu	37	12	29908673	29908673	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:29908673G>T	uc001rjb.2	-	4	850	c.376C>A	c.(376-378)CTC>ATC	p.L126I	TMTC1_uc001rjc.1_Missense_Mutation_p.L126I	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	234						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					AGGGAAAAGAGGTCATAAACC	0.433			NA											46	13					3.21987e-24	5.32226e-24	0.00361	1	0
KRT85	3891	broad.mit.edu	37	12	52756686	52756686	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:52756686G>A	uc001sag.2	-	6	1149	c.1029C>T	c.(1027-1029)AAC>AAT	p.N343N		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	343	Rod.|Coil 2.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GGATCATGCGGTTCAGCTCGT	0.582			NA											96	34					0	0	0.00361	0	0
GRIP1	23426	broad.mit.edu	37	12	66765685	66765685	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:66765685G>T	uc001stk.2	-	22	2886	c.2645C>A	c.(2644-2646)ACG>AAG	p.T882K	GRIP1_uc010sta.1_Missense_Mutation_p.T826K|GRIP1_uc001stj.2_Missense_Mutation_p.T649K|GRIP1_uc001stl.1_Missense_Mutation_p.T759K|GRIP1_uc001stm.2_Missense_Mutation_p.T867K	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	934					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CAAACTCATCGTGCTCCCCGA	0.512			NA											84	30					8.2577e-42	1.63409e-41	0.00361	1	0
NAV3	89795	broad.mit.edu	37	12	78574707	78574707	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:78574707C>A	uc001syp.2	+	30	5747	c.5574C>A	c.(5572-5574)AAC>AAA	p.N1858K	NAV3_uc001syo.2_Missense_Mutation_p.N1836K|NAV3_uc010sub.1_Missense_Mutation_p.N1315K|NAV3_uc009zsf.2_Missense_Mutation_p.N667K	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1858	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAACTGGTAACACAGCTAAGC	0.408			NA								HNSCC(70;0.22)			62	12					2.40265e-35	4.56179e-35	0.00361	1	0
STAB2	55576	broad.mit.edu	37	12	104030904	104030904	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:104030904C>T	uc001tjw.2	+	7	785	c.599C>T	c.(598-600)GCA>GTA	p.A200V		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	200	Extracellular (Potential).|EGF-like 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCTGAATGTGCAGCCTTGCTC	0.428			NA											132	40					0	0	0.00361	0	0
NUAK1	9891	broad.mit.edu	37	12	106477704	106477704	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:106477704C>A	uc001tlj.1	-	4	1897	c.517G>T	c.(517-519)GGT>TGT	p.G173C		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	173	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TGGACCACACCGTTCTGAAAT	0.488			NA											110	24					1.89039e-43	3.79428e-43	0.00361	1	0
CSNK1A1L	122011	broad.mit.edu	37	13	37678663	37678663	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr13:37678663G>T	uc001uwm.1	-	1	1139	c.731C>A	c.(730-732)CCT>CAT	p.P244H		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	244	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		AACTTCAACAGGGGTGGACAT	0.418			NA											45	28					1.76056e-25	2.98022e-25	0.011902	1	0
ENOX1	55068	broad.mit.edu	37	13	43930154	43930154	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr13:43930154G>T	uc001uza.3	-	8	1024	c.724C>A	c.(724-726)CGG>AGG	p.R242R	ENOX1_uc001uzb.3_Silent_p.R242R|ENOX1_uc001uzc.3_Silent_p.R242R|ENOX1_uc001uyz.3_5'UTR|ENOX1_uc010tfm.1_Silent_p.R55R	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	242					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		AGCTTGCGCCGGTGCCGCTCC	0.617			NA											74	32					6.00099e-30	1.08095e-29	0.00361	1	0
RB1	5925	broad.mit.edu	37	13	49039189	49039189	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr13:49039189A>G	uc001vcb.2	+	22	2433	c.2267A>G	c.(2266-2268)TAT>TGT	p.Y756C		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	756	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)|p.Y756*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATAGTATTCTATAACTCGGTC	0.299			6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			22	47					0	0	0.003954	0	0
MYCBP2	23077	broad.mit.edu	37	13	77631213	77631213	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr13:77631213T>C	uc001vkf.2	-	80	13322	c.13231A>G	c.(13231-13233)ATA>GTA	p.I4411V	MYCBP2_uc010aev.2_Missense_Mutation_p.I3815V|MYCBP2_uc001vke.2_Missense_Mutation_p.I1028V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4411	RING-type; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AAGTGGAATATGTGACTACAA	0.363			NA											39	87					0	0	0.00623	0	0
JPH4	84502	broad.mit.edu	37	14	24045665	24045665	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:24045665C>T	uc001wkq.2	-	4	1298	c.380G>A	c.(379-381)GGC>GAC	p.G127D	JPH4_uc001wkr.2_Missense_Mutation_p.G127D|JPH4_uc001wks.2_Missense_Mutation_p.G127D	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	127	Cytoplasmic (Potential).|MORN 4.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CTGGTAGGTGCCTGCGGGCGG	0.731			NA											3	5					0	0	0.004672	0	0
LTB4R	1241	broad.mit.edu	37	14	24785218	24785218	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:24785218C>A	uc001wos.2	+	2	682	c.361C>A	c.(361-363)CGC>AGC	p.R121S	LTB4R_uc010alp.2_Missense_Mutation_p.R121S|LTB4R_uc001wou.2_Missense_Mutation_p.R121S	NM_001143919	NP_001137391	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	121	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding				0				GBM - Glioblastoma multiforme(265;0.018)		GGCGGTGGCCCGCCCCTTTGT	0.642			NA											15	33					3.45872e-05	3.85674e-05	0.004007	1	0
CLEC14A	161198	broad.mit.edu	37	14	38724679	38724679	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:38724679G>A	uc001wum.1	-	1	896	c.549C>T	c.(547-549)CGC>CGT	p.R183R		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	183	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		cggccccggggcgcggcgcAG	0.562			NA											37	53					0	0	0.010771	0	0
MIA2	117153	broad.mit.edu	37	14	39717248	39717248	+	Silent	SNP	T	T	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:39717248T>C	uc001wux.2	+	4	1664	c.1470T>C	c.(1468-1470)AAT>AAC	p.N490N	MIA2_uc010amy.1_Silent_p.N421N	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	490						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		ATCAAAATAATGTAATTGAAA	0.313			NA											55	86					0	0	0.00361	0	0
TBPL2	387332	broad.mit.edu	37	14	55907125	55907125	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:55907125A>T	uc001xby.2	-	1	139	c.139T>A	c.(139-141)TGC>AGC	p.C47S		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	47					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						TGAGCGGCGCACTGGTCCAGG	0.502			NA											31	55					0	0	0.010818	0	0
SYT16	83851	broad.mit.edu	37	14	62547784	62547784	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:62547784G>T	uc001xfu.1	+	4	1423	c.1226G>T	c.(1225-1227)GGG>GTG	p.G409V	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	409	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ATACAGAGAGGGCCCAACCCC	0.592			NA											17	18					3.52763e-06	4.06256e-06	0.00499	1	0
ADAM20	8748	broad.mit.edu	37	14	70990220	70990220	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:70990220C>A	uc001xme.2	-	2	1650	c.1405G>T	c.(1405-1407)GAG>TAG	p.E469*		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	419	Disintegrin.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TCACATTCCTCCCCTTCTTCA	0.443			NA											74	152					3.89499e-28	6.84057e-28	0.00361	1	0
C14orf115	55237	broad.mit.edu	37	14	74824273	74824273	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:74824273C>A	uc001xpw.3	+	2	978	c.787C>A	c.(787-789)CCA>ACA	p.P263T		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	263					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		AGCCCTGGCCCCACTCTCATC	0.632			NA											22	30					2.39556e-15	3.50601e-15	0.00278	1	0
CALM1	801	broad.mit.edu	37	14	90870237	90870237	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:90870237G>T	uc001xyl.1	+	4	412	c.210G>T	c.(208-210)TTG>TTT	p.L70F	CALM1_uc010atq.1_Missense_Mutation_p.L71F|CALM1_uc010atr.1_Intron|CALM1_uc001xym.1_Missense_Mutation_p.L34F	NM_006888	NP_008819	P62158	CALM_HUMAN	calmodulin 1 isoform 1	70	EF-hand 2.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)	1		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	CCGAATTTTTGACTATGATGG	0.383			NA											12	27					2.80697e-09	3.53704e-09	0.010729	1	0
SERPINA4	5267	broad.mit.edu	37	14	95030231	95030231	+	Missense_Mutation	SNP	C	C	G	rs140563422	byFrequency	TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr14:95030231C>G	uc001ydk.2	+	2	478	c.412C>G	c.(412-414)CGC>GGC	p.R138G	SERPINA4_uc010avd.2_Missense_Mutation_p.R175G|SERPINA4_uc001ydl.2_Missense_Mutation_p.R138G	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	138					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		GCTGGAAACACGCGTGGGCAG	0.562			NA											36	66					0	0	0.004289	0	0
FMN1	342184	broad.mit.edu	37	15	33091096	33091096	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr15:33091096T>A	uc001zhf.3	-	15	3370	c.3370A>T	c.(3370-3372)ACA>TCA	p.T1124S		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1347	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TAGCTGGGTGTGATCTCCTTC	0.428			NA											13	23					0	0	0.001855	0	0
PLCB2	5330	broad.mit.edu	37	15	40594168	40594168	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr15:40594168G>A	uc001zld.2	-	7	873	c.572C>T	c.(571-573)CCC>CTC	p.P191L	PLCB2_uc010bbo.2_Missense_Mutation_p.P191L|PLCB2_uc010ucm.1_Missense_Mutation_p.P191L|PLCB2_uc001zle.3_Missense_Mutation_p.P191L	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	191					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TTTGCCTTTGGGGAGGTGGCA	0.582			NA											23	39					0	0	0.004656	0	0
UNC13C	440279	broad.mit.edu	37	15	54305977	54305977	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr15:54305977A>T	uc002ack.2	+	1	877	c.877A>T	c.(877-879)ACA>TCA	p.T293S		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	293					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCAGTTGCGCACAGGGTTTGT	0.453			NA											62	135					0	0	0.00361	0	0
BNC1	646	broad.mit.edu	37	15	83926424	83926424	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr15:83926424G>T	uc002bjt.1	-	5	2843	c.2755C>A	c.(2755-2757)CTT>ATT	p.L919I	BNC1_uc010uos.1_Missense_Mutation_p.L907I	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	919					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AGGCTAGCAAGGCTCTGGTCA	0.527			NA											82	185					1.84514e-49	3.73011e-49	0.00361	1	0
XYLT1	64131	broad.mit.edu	37	16	17211799	17211799	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:17211799C>T	uc002dfa.2	-	11	2346	c.2261G>A	c.(2260-2262)CGC>CAC	p.R754H		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	754	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CCCAAAGTTGCGGAATAGCCT	0.572			NA											17	23					0	0	0.012319	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24942256	24942256	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:24942256C>T	uc002dnb.2	-	19	2457	c.2364G>A	c.(2362-2364)CAG>CAA	p.Q788Q	ARHGAP17_uc002dmx.2_Silent_p.Q50Q|ARHGAP17_uc002dmw.2_Silent_p.Q50Q|ARHGAP17_uc002dmy.2_Silent_p.Q233Q|ARHGAP17_uc002dmz.2_Silent_p.Q312Q|ARHGAP17_uc002dna.2_Silent_p.Q515Q|ARHGAP17_uc002dnc.2_Silent_p.Q710Q|ARHGAP17_uc010vcf.1_Silent_p.Q531Q|ARHGAP17_uc002dne.1_Silent_p.Q50Q	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	788	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CAGCATGTGGCTGTGCAGTTT	0.632			NA											26	98					0	0	0.00333	0	0
TAOK2	9344	broad.mit.edu	37	16	29998953	29998953	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:29998953G>A	uc002dva.1	+	16	4143	c.3360G>A	c.(3358-3360)AAG>AAA	p.K1120K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Silent_p.K1127K|TAOK2_uc002dvd.1_Silent_p.K947K	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	1120					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						AAACCAACAAGGATGGCTTCC	0.667			NA											27	98					0	0	0.005443	0	0
ITGAM	3684	broad.mit.edu	37	16	31284711	31284711	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:31284711G>A	uc002ebq.2	+	8	828	c.730G>A	c.(730-732)GGA>AGA	p.G244R	ITGAM_uc002ebr.2_Missense_Mutation_p.G244R|ITGAM_uc010cam.1_5'Flank	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	244	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CATCACCAACGGAGCCCGAAA	0.423			NA											54	65					0	0	0.00361	0	0
ITGAX	3687	broad.mit.edu	37	16	31388320	31388320	+	Splice_Site	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:31388320G>T	uc002ebu.1	+	22	2693	c.2626_splice	c.e22-1	p.I876_splice	ITGAX_uc002ebt.2_Splice_Site_p.I876_splice	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor						blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTTTTCCTCAGATCACCTTCT	0.622			NA											16	81					1.5739e-10	2.04752e-10	0.004007	1	0
ABCC11	85320	broad.mit.edu	37	16	48210987	48210987	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:48210987G>A	uc002eff.1	-	24	3736	c.3386C>T	c.(3385-3387)ACA>ATA	p.T1129I	ABCC11_uc002efg.1_Missense_Mutation_p.T1129I|ABCC11_uc002efh.1_Missense_Mutation_p.T1129I|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1129	Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGGACAACTTGTGCCTTCCAT	0.463			NA							Cerumen_Type				24	15					0	0	0.004656	0	0
SALL1	6299	broad.mit.edu	37	16	51174869	51174869	+	Silent	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:51174869A>G	uc010vgs.1	-	2	1295	c.1264T>C	c.(1264-1266)TTG>CTG	p.L422L	SALL1_uc010vgr.1_Silent_p.L325L|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	422					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGCTGGGCCAAGGCAGACAAG	0.493	GBM(103;1352 1446 1855 4775 8890)		NA											93	92					0	0	0.00361	0	0
C16orf48	84080	broad.mit.edu	37	16	67698948	67698948	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:67698948C>T	uc002etw.1	-	3	687	c.404G>A	c.(403-405)CGC>CAC	p.R135H	C16orf48_uc002etv.1_5'Flank|C16orf48_uc010cem.1_Missense_Mutation_p.R135H|C16orf86_uc002etx.1_5'Flank|C16orf86_uc002ety.2_5'Flank|C16orf86_uc002etz.2_5'Flank	NM_032140	NP_115516	Q9H0I2	CP048_HUMAN	hypothetical protein LOC84080	135						microtubule cytoskeleton	protein binding				0		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTTGGGTGAGCGCCACAGAGC	0.597			NA											43	130					0	0	0.00874	0	0
DHX38	9785	broad.mit.edu	37	16	72141383	72141383	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:72141383C>T	uc002fcb.2	+	20	3100	c.2745C>T	c.(2743-2745)CCC>CCT	p.P915P	DHX38_uc010vmp.1_Silent_p.P227P	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	915					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				TGGACCCGCCCCCGGAGGACA	0.637	Melanoma(97;711 1442 7855 13832 28836)		NA											20	25					0	0	0.008871	0	0
CHST5	23563	broad.mit.edu	37	16	75563159	75563159	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:75563159A>G	uc002fei.2	-	3	2519	c.1124T>C	c.(1123-1125)CTG>CCG	p.L375P	CHST5_uc002fej.1_Missense_Mutation_p.L381P	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	375	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CAGCAGCTGCAGCGCGCCGGC	0.657			NA											23	22					0	0	0.003954	0	0
PKD1L2	114780	broad.mit.edu	37	16	81228608	81228608	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:81228608C>A	uc002fgh.1	-	8	1566	c.1566G>T	c.(1564-1566)CTG>CTT	p.L522L	PKD1L2_uc002fgj.2_Silent_p.L522L	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	522	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CATTCCTCACCAGCATGGTGA	0.473			NA											13	53					4.93089e-13	6.75893e-13	0.00245	1	0
PKD1L2	114780	broad.mit.edu	37	16	81253859	81253859	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:81253859G>A	uc002fgh.1	-	1	117	c.117C>T	c.(115-117)TGC>TGT	p.C39C	PKD1L2_uc002fgj.2_Silent_p.C39C	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	39	Extracellular (Potential).|C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAAATTCATAGCAAGCATCTC	0.562			NA											49	41					0	0	0.00361	0	0
LRRC50	123872	broad.mit.edu	37	16	84199428	84199428	+	Silent	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:84199428T>A	uc002fhl.3	+	7	1084	c.903T>A	c.(901-903)GCT>GCA	p.A301A	LRRC50_uc010vnw.1_Silent_p.A49A	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	301					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						GGTACGCAGCTGAAAAGGAGG	0.517			NA							Kartagener_syndrome				57	73					0	0	0.00361	0	0
FOXF1	2294	broad.mit.edu	37	16	86545096	86545096	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:86545096C>T	uc002fjl.2	+	1	964	c.921C>T	c.(919-921)CAC>CAT	p.H307H	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	307					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0						TCTCCACGCACTCCCTGGAGC	0.692			NA											6	9					0	0	0.001168	0	0
SPG7	6687	broad.mit.edu	37	16	89592826	89592826	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr16:89592826G>T	uc002fnj.2	+	5	729	c.708G>T	c.(706-708)GAG>GAT	p.E236D	SPG7_uc002fni.2_Missense_Mutation_p.E236D	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	236	Mitochondrial intermembrane (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		TGAATATCGAGGCCAAGGACA	0.458			NA											50	61					2.29192e-23	3.72271e-23	0.00361	1	0
PLD2	5338	broad.mit.edu	37	17	4713204	4713204	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:4713204A>G	uc002fzc.2	+	9	841	c.740A>G	c.(739-741)TAC>TGC	p.Y247C	PLD2_uc010vsj.1_Missense_Mutation_p.Y104C|PLD2_uc002fzd.2_Missense_Mutation_p.Y247C	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	247	PH.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	TTCCTGCTGTACATGTGCCTC	0.572			NA											85	48					0	0	0.00361	0	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Silent	SNP	C	C	A	rs55863639		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:7579312C>A	uc002gim.2	-	4	569	c.375G>T	c.(373-375)ACG>ACT	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	18					2.52637e-11	3.33291e-11	0.005524	1	0
MYH4	4622	broad.mit.edu	37	17	10363568	10363568	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:10363568T>A	uc002gmn.2	-	13	1329	c.1218A>T	c.(1216-1218)AGA>AGT	p.R406S	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	406	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CGACCTTGACTCTGGGATAGC	0.453			NA											66	59					0	0	0.00361	0	0
TOP2A	7153	broad.mit.edu	37	17	38560655	38560655	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:38560655T>A	uc002huq.2	-	18	2261	c.2135A>T	c.(2134-2136)GAG>GTG	p.E712V		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	712					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GATAGATCTCTCGTTATCAGA	0.343			NA											40	74					0	0	0.006999	0	0
KRT24	192666	broad.mit.edu	37	17	38859882	38859882	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:38859882C>A	uc002hvd.2	-	1	121	c.64G>T	c.(64-66)GCT>TCT	p.A22S		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	22	Head.|Gly-rich.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CTTCCACCAGCAGACACCCTG	0.642	GBM(61;380 1051 14702 23642 31441)		NA											26	29					2.4375e-19	3.78418e-19	0.007291	1	0
KRT17	3872	broad.mit.edu	37	17	39778674	39778674	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:39778674G>T	uc002hxh.2	-	3	726	c.605C>A	c.(604-606)GCC>GAC	p.A202D	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	202	Coil 1B.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				CTCCAGGTCGGCTCTGGCCAG	0.607	Pancreas(92;1242 2086 39193 50508)		NA							Steatocystoma_Multiplex				57	109					1.80625e-27	3.13307e-27	0.00361	1	0
GNGT2	2793	broad.mit.edu	37	17	47284772	47284772	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:47284772G>T	uc002ioo.1	-	3	320	c.13C>A	c.(13-15)CTC>ATC	p.L5I	ABI3_uc002ioq.1_5'Flank|ABI3_uc002iop.1_5'Flank	NM_031498	NP_113686	O14610	GBGT2_HUMAN	guanine nucleotide binding protein-gamma	5					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			TTCTCGCTGAGATCCTGGGCC	0.537			NA											116	176					1.71345e-61	3.59313e-61	0.00361	1	0
EPX	8288	broad.mit.edu	37	17	56277675	56277675	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:56277675C>A	uc002ivq.2	+	10	1713	c.1627C>A	c.(1627-1629)CGG>AGG	p.R543R		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	543					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						GCTCCGGGACCGGCTGTTTCG	0.647			NA									OREG0024608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	68					3.77016e-25	6.30604e-25	0.013114	1	0
TBX4	9496	broad.mit.edu	37	17	59560748	59560748	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:59560748G>A	uc002izi.2	+	8	1554	c.1509G>A	c.(1507-1509)AGG>AGA	p.R503R	TBX4_uc010ddo.2_Silent_p.R504R|TBX4_uc010woy.1_Silent_p.R504R	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	503					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GGTGTGAGAGGAAGCCACCCT	0.547			NA											28	42					0	0	0.00632	0	0
BRIP1	83990	broad.mit.edu	37	17	59937249	59937249	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:59937249C>A	uc002izk.1	-	3	254	c.113G>T	c.(112-114)AGC>ATC	p.S38I		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	38	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ATGTTGCTTGCTGTTTAATCC	0.353			NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				26	43					4.7796e-09	5.96919e-09	0.004656	1	0
MAP3K3	4215	broad.mit.edu	37	17	61767648	61767648	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:61767648G>T	uc002jbg.2	+	12	1407	c.1088G>T	c.(1087-1089)CGC>CTC	p.R363L	MAP3K3_uc002jbe.2_Missense_Mutation_p.R394L|MAP3K3_uc002jbf.2_Missense_Mutation_p.R394L|MAP3K3_uc002jbh.2_Missense_Mutation_p.R390L|MAP3K3_uc010wpo.1_Missense_Mutation_p.R278L|MAP3K3_uc010wpp.1_Missense_Mutation_p.R359L	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	363	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						ATCAACTGGCGCCGGGGAAAG	0.517			NA											55	90					8.28887e-21	1.32339e-20	0.00361	1	0
UBE2O	63893	broad.mit.edu	37	17	74392671	74392671	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:74392671C>A	uc002jrm.3	-	14	2412	c.2347G>T	c.(2347-2349)GCT>TCT	p.A783S	UBE2O_uc002jrn.3_Missense_Mutation_p.A783S|UBE2O_uc002jrl.3_Missense_Mutation_p.A387S	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	783							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						TGGACGGCAGCTGTGGCTGCC	0.662			NA											72	122					2.48295e-43	4.94829e-43	0.00361	1	0
RPTOR	57521	broad.mit.edu	37	17	78681705	78681705	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:78681705G>T	uc002jyt.1	+	4	1218	c.413G>T	c.(412-414)CGT>CTT	p.R138L	RPTOR_uc002jys.2_Missense_Mutation_p.R138L|RPTOR_uc010wuf.1_5'UTR|RPTOR_uc010wug.1_Missense_Mutation_p.R138L	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	138					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						ACGTCCTTACGTCGCAACGCC	0.562			NA											21	28					1.00905e-13	1.41066e-13	0.008871	1	0
ROCK1	6093	broad.mit.edu	37	18	18629083	18629083	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr18:18629083C>A	uc002kte.2	-	4	1325	c.384G>T	c.(382-384)ATG>ATT	p.M128I		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	128	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TGGCAAAAGCCATGATGTCCC	0.373			NA											44	65					4.44401e-20	6.97635e-20	0.010771	1	0
DSC3	1825	broad.mit.edu	37	18	28598198	28598198	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr18:28598198C>T	uc002kwj.3	-	9	1257	c.1102G>A	c.(1102-1104)GCA>ACA	p.A368T	DSC3_uc002kwi.3_Missense_Mutation_p.A368T	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	368	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ACATTGAATGCATTTTCCTCT	0.279			NA											16	28					0	0	0.00499	0	0
INO80C	125476	broad.mit.edu	37	18	33048628	33048628	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr18:33048628C>A	uc002kyy.3	-	5	643	c.526G>T	c.(526-528)GAC>TAC	p.D176Y	INO80C_uc002kyw.1_Intron|INO80C_uc002kyx.3_Missense_Mutation_p.D121Y|INO80C_uc010dmt.2_Missense_Mutation_p.D212Y	NM_194281	NP_919257	Q6PI98	IN80C_HUMAN	Ies6-similar protein isoform 2	176					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|MLL1 complex					0						GTGACGACGTCAGAGGGCAGC	0.557			NA											81	161					1.51503e-27	2.64425e-27	0.00361	1	0
ZNF443	10224	broad.mit.edu	37	19	12542605	12542605	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:12542605C>T	uc002mtu.2	-	4	579	c.381G>A	c.(379-381)GGG>GGA	p.G127G		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	127					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GTGGTTTGTGCCCAGCACCAA	0.433			NA											4	78					0	0	0.009096	0	0
EMR3	84658	broad.mit.edu	37	19	14736374	14736374	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:14736374A>T	uc002mzi.3	-	15	1998	c.1850T>A	c.(1849-1851)GTA>GAA	p.V617E	EMR3_uc010dzp.2_Missense_Mutation_p.V565E|EMR3_uc010xnv.1_Missense_Mutation_p.V491E	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	617	Cytoplasmic (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						TTTTGATTTTACGATCTCTCT	0.403			NA											63	39					0	0	0.00361	0	0
IL12RB1	3594	broad.mit.edu	37	19	18174812	18174812	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:18174812C>T	uc002nhw.1	-	13	1556	c.1492G>A	c.(1492-1494)GTG>ATG	p.V498M	IL12RB1_uc010xqb.1_Missense_Mutation_p.V498M|IL12RB1_uc002nhx.1_Missense_Mutation_p.V538M	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	498	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GTGGGCTGCACGGGATGCTCT	0.637			NA											12	4					0	0	0.010729	0	0
PSG2	5670	broad.mit.edu	37	19	43579616	43579616	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:43579616C>A	uc002ovr.2	-	3	692	c.599G>T	c.(598-600)AGG>ATG	p.R200M	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.R200M|PSG2_uc010eiq.1_Missense_Mutation_p.R200M|PSG2_uc002ovs.3_Missense_Mutation_p.R200M|PSG2_uc002ovt.3_Missense_Mutation_p.R200M	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	200	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				AAAGAGGGTCCTGTTGGTTTC	0.507			NA											232	322					4.32306e-105	9.20288e-105	0.00361	1	0
ZNF235	9310	broad.mit.edu	37	19	44791609	44791609	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:44791609C>T	uc002oza.3	-	5	2082	c.1979G>A	c.(1978-1980)TGT>TAT	p.C660Y	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Missense_Mutation_p.C656Y|ZNF235_uc010xwx.1_Missense_Mutation_p.C574Y	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	660	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				TTCTTTCCCACATTCCTCACA	0.463			NA											62	90					0	0	0.00361	0	0
MYH14	79784	broad.mit.edu	37	19	50735303	50735303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:50735303G>T	uc002prr.1	+	9	1113	c.1066G>T	c.(1066-1068)GGA>TGA	p.G356*	MYH14_uc010enu.1_Nonsense_Mutation_p.G364*|MYH14_uc002prq.1_Nonsense_Mutation_p.G364*	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	356	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCGGGTCCTGGGATTCAGCCA	0.662			NA											26	35					1.33986e-20	2.11518e-20	0.004656	1	0
ZNF347	84671	broad.mit.edu	37	19	53645328	53645328	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:53645328C>T	uc002qbb.1	-	5	822	c.753G>A	c.(751-753)GGG>GGA	p.G251G	ZNF347_uc010eql.1_Silent_p.G252G|ZNF347_uc002qbc.1_Silent_p.G252G	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TTGCTTTTTGCCCCTGTGTGA	0.373	Melanoma(64;205 1597 17324 45721)		NA											4	165					0	0	0.009096	0	0
LILRA4	23547	broad.mit.edu	37	19	54850356	54850356	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:54850356G>T	uc002qfj.2	-	1	66	c.9C>A	c.(7-9)CTC>CTA	p.L3L	LILRA4_uc002qfi.2_5'UTR	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	3				L -> P (in Ref. 1; AAD02203).		integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TTGTGAGAATGAGGGTCATGG	0.572			NA											17	40					1.02788e-11	1.36889e-11	0.00499	1	0
PEG3	5178	broad.mit.edu	37	19	57328066	57328066	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:57328066G>T	uc002qnu.2	-	7	2095	c.1744C>A	c.(1744-1746)CAG>AAG	p.Q582K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Q553K|PEG3_uc002qnv.2_Missense_Mutation_p.Q582K|PEG3_uc002qnw.2_Missense_Mutation_p.Q458K|PEG3_uc002qnx.2_Missense_Mutation_p.Q456K|PEG3_uc010etr.2_Missense_Mutation_p.Q582K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	582	C2H2-type 3.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGGATTTTCTGGTGCTCAATC	0.388			NA											26	68					7.33532e-06	8.2449e-06	0.003954	1	0
GREB1	9687	broad.mit.edu	37	2	11738806	11738806	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:11738806G>A	uc002rbk.1	+	15	2453	c.2153G>A	c.(2152-2154)GGG>GAG	p.G718E	GREB1_uc002rbo.1_Missense_Mutation_p.G352E	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	718						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TGTGTTGCAGGGGTTTTGCTG	0.348	Ovarian(39;850 945 2785 23371 33093)		NA											53	96					0	0	0.00361	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17697597	17697597	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:17697597C>A	uc002rcl.1	-	1	2110	c.2086G>T	c.(2086-2088)GAC>TAC	p.D696Y	RAD51AP2_uc010exn.1_Missense_Mutation_p.D687Y	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	696										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TCATCCATGTCATCAAAGTCC	0.303			NA											32	57					2.81731e-10	3.64823e-10	0.010818	1	0
CAD	790	broad.mit.edu	37	2	27458430	27458430	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:27458430G>T	uc002rji.2	+	25	4158	c.3996G>T	c.(3994-3996)GTG>GTT	p.V1332V	CAD_uc010eyw.2_Silent_p.V1269V	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1332	CPSase B.|CPSase (Carbamoyl-phosphate synthase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TCCCAACTGTGCGGCTACTGG	0.537			NA											39	71					2.00842e-17	3.10091e-17	0.010771	1	0
FSHR	2492	broad.mit.edu	37	2	49216164	49216164	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:49216164G>T	uc002rww.2	-	6	550	c.476C>A	c.(475-477)ACA>AAA	p.T159K	FSHR_uc002rwx.2_Missense_Mutation_p.T159K|FSHR_uc010fbn.2_Intron|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	159	LRR 5.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCTTTCAATTGTGTGGATGTT	0.328			NA							Gonadal_Dysgenesis_46_XX				19	25					1.10513e-12	1.48585e-12	0.002299	1	0
ZNF638	27332	broad.mit.edu	37	2	71654429	71654429	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:71654429G>C	uc002shx.2	+	24	5749	c.5430G>C	c.(5428-5430)AAG>AAC	p.K1810N	ZNF638_uc002shy.2_Missense_Mutation_p.K1810N|ZNF638_uc002shz.2_Missense_Mutation_p.K1810N|ZNF638_uc002sia.2_Missense_Mutation_p.K1810N|ZNF638_uc002sib.1_3'UTR|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.K907N|ZNF638_uc002sid.2_Missense_Mutation_p.K179N	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1810					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGAATAGAAAGAAGAGAGCTG	0.368			NA											28	63					0	0	0.005443	0	0
C2orf78	388960	broad.mit.edu	37	2	74043317	74043317	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:74043317T>A	uc002sjr.1	+	3	2088	c.1967T>A	c.(1966-1968)CTG>CAG	p.L656Q		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	656										ovary(2)	2						TCCAGGACCCTGGGAAGCTCA	0.507			NA											19	57					0	0	0.008871	0	0
ACTG2	72	broad.mit.edu	37	2	74128468	74128468	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:74128468G>T	uc002sjw.2	+	2	152	c.30G>T	c.(28-30)GTG>GTT	p.V10V	ACTG2_uc010fex.1_Silent_p.V10V|ACTG2_uc010fey.2_Silent_p.V10V|ACTG2_uc010yrn.1_Silent_p.V10V	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	10					muscle contraction	cytoskeleton|cytosol	ATP binding				0						CCGCGCTCGTGTGTGACAATG	0.622			NA											17	33					2.48551e-13	3.42366e-13	0.00499	1	0
MYO7B	4648	broad.mit.edu	37	2	128347777	128347777	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:128347777C>A	uc002top.2	+	16	2018	c.1965C>A	c.(1963-1965)ATC>ATA	p.I655I		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	655	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TCCGCTGCATCAAACCTAATG	0.532			NA											19	28					2.32416e-17	3.56879e-17	0.002299	1	0
WDR33	55339	broad.mit.edu	37	2	128477085	128477085	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:128477085C>A	uc002tpg.1	-	16	2697	c.2514G>T	c.(2512-2514)GGG>GGT	p.G838G		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	838					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGGGTGGAGGCCCCTGCATGC	0.627			NA											22	31					2.70639e-06	3.15559e-06	0.002299	1	0
FAM123C	205147	broad.mit.edu	37	2	131521635	131521635	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:131521635G>C	uc002trw.2	+	2	2180	c.1990G>C	c.(1990-1992)GGT>CGT	p.G664R	FAM123C_uc010fmv.2_Missense_Mutation_p.G664R|FAM123C_uc010fms.1_Missense_Mutation_p.G664R|FAM123C_uc010fmt.1_Missense_Mutation_p.G664R|FAM123C_uc010fmu.1_Missense_Mutation_p.G664R	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	664										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGTCACGGAGGTGACACTCT	0.662			NA											8	18					0	0	0.00308	0	0
ZRANB3	84083	broad.mit.edu	37	2	136107556	136107556	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:136107556C>T	uc002tum.2	-	5	706	c.589G>A	c.(589-591)GAG>AAG	p.E197K	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.E197K|ZRANB3_uc002tun.1_Missense_Mutation_p.E137K	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	197	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		TGTAATACCTCTTCAGGCCTT	0.408			NA											30	40					0	0	0.004878	0	0
THSD7B	80731	broad.mit.edu	37	2	137928486	137928486	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:137928486G>T	uc002tva.1	+	6	1608	c.1608G>T	c.(1606-1608)AAG>AAT	p.K536N	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.K426N	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GTATTCTGAAGGCCGTCTGCC	0.493			NA											16	31					2.23348e-06	2.61504e-06	0.004007	1	0
ZEB2	9839	broad.mit.edu	37	2	145156362	145156362	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:145156362T>A	uc002tvu.2	-	8	2872	c.2392A>T	c.(2392-2394)AGT>TGT	p.S798C	ZEB2_uc002tvv.2_Missense_Mutation_p.S792C|ZEB2_uc010zbm.1_Missense_Mutation_p.S769C|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.S827C	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	798						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TATGAACTACTGTGGGAGTTT	0.388	Melanoma(33;1235 1264 5755 16332)		NA											76	128					0	0	0.00361	0	0
TANC1	85461	broad.mit.edu	37	2	159992709	159992709	+	Silent	SNP	C	C	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:159992709C>G	uc002uag.2	+	5	538	c.264C>G	c.(262-264)CCC>CCG	p.P88P	TANC1_uc010fol.1_Silent_p.P88P|TANC1_uc010zcm.1_Silent_p.P88P|TANC1_uc010fom.1_Silent_p.P88P|TANC1_uc002uah.1_5'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	88						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CTACAGGTCCCGTCAGGAAGC	0.483			NA											52	99					0	0	0.00361	0	0
PSMD14	10213	broad.mit.edu	37	2	162224311	162224311	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:162224311G>A	uc002ubu.2	+	5	604	c.137G>A	c.(136-138)CGT>CAT	p.R46H		NM_005805	NP_005796	O00487	PSDE_HUMAN	proteasome 26S subunit, non-ATPase 14	46	MPN.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)	1						AAACATGGCCGTGCTGGAGTT	0.388			NA											21	32					0	0	0.012319	0	0
KCNH7	90134	broad.mit.edu	37	2	163693240	163693240	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:163693240G>T	uc002uch.1	-	2	326	c.114C>A	c.(112-114)AAC>AAA	p.N38K	KCNH7_uc002uci.2_Missense_Mutation_p.N38K	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	38	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TGATGGCACAGTTCTGCACTC	0.418	GBM(196;1492 2208 17507 24132 45496)		NA											24	30					4.26978e-12	5.71337e-12	0.00333	1	0
TLK1	9874	broad.mit.edu	37	2	171867901	171867901	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:171867901G>T	uc002ugn.2	-	14	1870	c.1398C>A	c.(1396-1398)GGC>GGA	p.G466G	TLK1_uc002ugo.2_Silent_p.G487G|TLK1_uc002ugp.2_Silent_p.G418G|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Silent_p.G370G	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	466	Protein kinase.|ATP (By similarity).				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						CTTCACTAAAGCCACCTCTAC	0.328			NA											14	56					2.23348e-06	2.61504e-06	0.004007	1	0
SLC25A12	8604	broad.mit.edu	37	2	172666787	172666787	+	Splice_Site	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:172666787C>A	uc002uhh.2	-	12	1261	c.1172_splice	c.e12-1	p.G391_splice	SLC25A12_uc010fqh.2_Splice_Site_p.G284_splice	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12						gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	GGTATCAGACCTAGGTAAAGG	0.378			NA											45	62					1.62263e-30	2.94166e-30	0.00361	1	0
KIAA1715	80856	broad.mit.edu	37	2	176812337	176812337	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:176812337C>A	uc002ukc.1	-	9	770	c.577G>T	c.(577-579)GTA>TTA	p.V193L	KIAA1715_uc010zer.1_Missense_Mutation_p.V193L|KIAA1715_uc010fqw.1_Missense_Mutation_p.V259L|KIAA1715_uc010zes.1_Missense_Mutation_p.V195L|KIAA1715_uc002ukd.1_Missense_Mutation_p.V70L|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	193	Cytoplasmic (Potential).|Pro-rich.					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			CCAGGAGATACTGGAACTTGT	0.512			NA											49	100					2.17126e-26	3.72026e-26	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179477551	179477551	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:179477551C>A	uc010zfg.1	-	214	42417	c.42193G>T	c.(42193-42195)GAA>TAA	p.E14065*	uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E7760*|TTN_uc010zfi.1_Nonsense_Mutation_p.E7693*|TTN_uc010zfj.1_Nonsense_Mutation_p.E7568*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14992							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTCACTTTCCCCAGCCTTA	0.502			NA											14	35					7.93312e-07	9.40594e-07	0.00245	1	0
SGOL2	151246	broad.mit.edu	37	2	201438669	201438669	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:201438669A>T	uc002uvw.2	+	7	3713	c.3600A>T	c.(3598-3600)AAA>AAT	p.K1200N	SGOL2_uc010zhd.1_Missense_Mutation_p.K1200N|SGOL2_uc010zhe.1_Missense_Mutation_p.K1200N	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	1200					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						TGAAATTTAAAGTCAACCGGA	0.318			NA											34	45					0	0	0.010818	0	0
ABCA12	26154	broad.mit.edu	37	2	215820017	215820017	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr2:215820017G>T	uc002vew.2	-	43	6522	c.6302C>A	c.(6301-6303)ACT>AAT	p.T2101N	ABCA12_uc002vev.2_Missense_Mutation_p.T1783N|ABCA12_uc010zjn.1_Missense_Mutation_p.T1028N	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2101					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACAGACGTAAGTGATGAAGGC	0.403	Ovarian(66;664 1488 5121 34295)		NA											15	28					2.32078e-09	2.93757e-09	0.003163	1	0
PCSK2	5126	broad.mit.edu	37	20	17462466	17462466	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr20:17462466C>A	uc002wpm.2	+	12	1988	c.1668C>A	c.(1666-1668)ACC>ACA	p.T556T	PCSK2_uc002wpl.2_Silent_p.T537T|PCSK2_uc010zrm.1_Silent_p.T521T|PCSK2_uc002wpn.2_Silent_p.T210T	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	556					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTTCATGACCACTCACACGT	0.607			NA											14	45					5.3912e-06	6.15825e-06	0.006122	1	0
PREX1	57580	broad.mit.edu	37	20	47273634	47273634	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr20:47273634G>T	uc002xtw.1	-	18	2090	c.2067C>A	c.(2065-2067)AAC>AAA	p.N689K	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	689	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGAAGGACTGGTTGAGGATGG	0.642			NA											8	8					0.00307968	0.00334127	0.00308	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47626850	47626850	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr20:47626850G>T	uc002xtx.3	+	27	3818	c.3666G>T	c.(3664-3666)TGG>TGT	p.W1222C	ARFGEF2_uc010zyf.1_Missense_Mutation_p.W515C	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1222					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GCTCAGGTTGGAAGAACATCT	0.567	Esophageal Squamous(176;1738 1974 26285 33069 35354)		NA											37	24					9.80977e-26	1.67063e-25	0.004289	1	0
COL9A3	1299	broad.mit.edu	37	20	61468487	61468487	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr20:61468487C>T	uc002ydm.2	+	30	1659	c.1656C>T	c.(1654-1656)TCC>TCT	p.S552S	COL9A3_uc002ydn.2_Silent_p.S46S	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	552	Triple-helical region 2 (COL2).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					CACCCGGGTCCATTGGTCGGC	0.632			NA											36	476					0	0	0.005524	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688836	26688836	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr22:26688836G>T	uc003acb.2	+	2	715	c.559G>T	c.(559-561)GAC>TAC	p.D187Y	SEZ6L_uc003acc.2_Missense_Mutation_p.D187Y|SEZ6L_uc011akc.1_Missense_Mutation_p.D187Y|SEZ6L_uc003acd.2_Missense_Mutation_p.D187Y|SEZ6L_uc011akd.1_Missense_Mutation_p.D187Y|SEZ6L_uc003ace.2_Missense_Mutation_p.D187Y|SEZ6L_uc003acf.1_5'UTR|SEZ6L_uc010gvc.1_5'UTR	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	187	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CCTTTGGCTGGACCGAAAGGA	0.647			NA											27	31					4.87955e-14	6.89022e-14	0.005443	1	0
RNF185	91445	broad.mit.edu	37	22	31583195	31583195	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr22:31583195T>A	uc003akb.2	+	2	315	c.115T>A	c.(115-117)TGC>AGC	p.C39S	RNF185_uc010gwh.2_RNA|RNF185_uc011alm.1_Missense_Mutation_p.S14R|RNF185_uc003akc.2_Missense_Mutation_p.S14R|RNF185_uc003ake.2_Missense_Mutation_p.C39S	NM_152267	NP_689480	Q96GF1	RN185_HUMAN	ring finger protein 185 isoform 1	39	RING-type.					integral to membrane	zinc ion binding				0						CACTTTCGAGTGCAACATCTG	0.617			NA											31	71					0	0	0.009535	0	0
FBLN2	2199	broad.mit.edu	37	3	13678060	13678060	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:13678060C>A	uc011avb.1	+	16	3314	c.3189C>A	c.(3187-3189)GTC>GTA	p.V1063V	FBLN2_uc011auz.1_Silent_p.V1089V|FBLN2_uc011ava.1_Silent_p.V1110V|FBLN2_uc011avc.1_Silent_p.V1110V	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	1063	EGF-like 10; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			ATGTCCAAGTCTCCAAAACGT	0.597			NA											10	6					7.48243e-07	8.90916e-07	0.006214	1	0
NBEAL2	23218	broad.mit.edu	37	3	47043987	47043987	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:47043987G>T	uc003cqp.2	+	32	5457	c.5278G>T	c.(5278-5280)GCC>TCC	p.A1760S	NBEAL2_uc010hjm.1_Missense_Mutation_p.A1137S|NBEAL2_uc010hjn.1_Missense_Mutation_p.A156S|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1760							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GTGGGAGCGCGCCCAGAGTCG	0.577			NA											24	14					3.5997e-14	5.18726e-14	0.002299	1	0
COL7A1	1294	broad.mit.edu	37	3	48610962	48610962	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:48610962C>A	uc003ctz.2	-	82	6603	c.6602G>T	c.(6601-6603)GGA>GTA	p.G2201V		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2201	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCAGAAGGTCCTTGGGGTCC	0.587			NA											33	19					3.76114e-14	5.36487e-14	0.004289	1	0
TLR9	54106	broad.mit.edu	37	3	52255676	52255676	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:52255676A>C	uc003dda.1	-	2	3290	c.2656T>G	c.(2656-2658)TGG>GGG	p.W886G	TLR9_uc003ddb.2_Missense_Mutation_p.W983G	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	886	TIR.|Cytoplasmic (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	TTGTACACCCAGTCTGCCACT	0.657			NA											64	128					0	0	0.00361	0	0
PROS1	5627	broad.mit.edu	37	3	93619674	93619674	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:93619674T>C	uc003drb.3	-	7	1042	c.701A>G	c.(700-702)TAT>TGT	p.Y234C	PROS1_uc010hoo.2_Missense_Mutation_p.Y103C|PROS1_uc003dqz.3_Missense_Mutation_p.Y103C	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	234	EGF-like 3; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTTGAGATTATATCTGTAGCC	0.433			NA											21	37					0	0	0.003954	0	0
LSAMP	4045	broad.mit.edu	37	3	116163754	116163754	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:116163754G>A	uc003ebt.2	-	1	625	c.125C>T	c.(124-126)ACC>ATC	p.T42I	LSAMP_uc011bis.1_Missense_Mutation_p.T42I|LSAMP_uc010hqq.1_RNA	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	42	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CTGCCTCACGGTGATGTTGTC	0.493			NA											4	16					0	0	0.009096	0	0
GMPS	8833	broad.mit.edu	37	3	155649570	155649570	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:155649570A>G	uc003faq.2	+	13	1912	c.1577A>G	c.(1576-1578)TAC>TGC	p.Y526C	GMPS_uc011bom.1_Missense_Mutation_p.Y427C	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	526					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TGTCGTTCCTACAGTTACGTG	0.343	Ovarian(153;896 1876 4149 15499 28134)		NA	T	MLL	AML								64	116					0	0	0.00361	0	0
GABRA2	2555	broad.mit.edu	37	4	46307719	46307719	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:46307719G>T	uc003gxc.3	-	6	1242	c.569C>A	c.(568-570)ACA>AAA	p.T190K	GABRA2_uc010igc.2_Missense_Mutation_p.T190K|GABRA2_uc011bzc.1_Missense_Mutation_p.T135K|GABRA2_uc003gxe.2_Missense_Mutation_p.T190K	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	190	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTCTGAAGTTGTATATGCATC	0.363			NA											22	21					8.10497e-08	9.9454e-08	0.010504	1	0
GNRHR	2798	broad.mit.edu	37	4	68619639	68619639	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:68619639G>T	uc003hdn.2	-	1	2166	c.415C>A	c.(415-417)CGC>AGC	p.R139S	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_Missense_Mutation_p.R139S	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	139	Cytoplasmic (Potential).		R -> H (in IHH; completely eliminates detectable GnRH-binding activity and prevents GnRH-induced stimulation of inositol phosphate accumulation in vitro).		multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GCCAGGGAGCGGTCCAGGCTG	0.517			NA											17	29					3.52763e-06	4.06256e-06	0.00499	1	0
SULT1B1	27284	broad.mit.edu	37	4	70596333	70596333	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:70596333C>T	uc003hen.2	-	7	962	c.664G>A	c.(664-666)GAT>AAT	p.D222N		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	222	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						ATGATCCTATCCAAGATCTCA	0.373			NA											19	20					0	0	0.008871	0	0
PPEF2	5470	broad.mit.edu	37	4	76781857	76781857	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:76781857G>A	uc003hix.2	-	17	2582	c.2225C>T	c.(2224-2226)GCT>GTT	p.A742V	PPEF2_uc003hiy.2_RNA	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	742					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ACTGTCTTTAGCATTTGTAGC	0.517	NSCLC(105;1359 1603 15961 44567 47947)		NA											12	20					0	0	0.010729	0	0
WDFY3	23001	broad.mit.edu	37	4	85642649	85642649	+	Silent	SNP	T	T	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:85642649T>C	uc003hpd.2	-	47	7926	c.7518A>G	c.(7516-7518)CAA>CAG	p.Q2506Q	WDFY3_uc003hpe.1_Silent_p.Q117Q	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2506						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CAATCTGGTCTTGTAGCTGCT	0.488			NA											36	75					0	0	0.002836	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99342456	99342456	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:99342456G>T	uc003htx.3	+	12	1541	c.1351G>T	c.(1351-1353)GTG>TTG	p.V451L	RAP1GDS1_uc003htw.3_Missense_Mutation_p.V452L|RAP1GDS1_uc003htv.3_Missense_Mutation_p.V451L|RAP1GDS1_uc003htz.3_Missense_Mutation_p.V402L|RAP1GDS1_uc003hty.3_Missense_Mutation_p.V403L|RAP1GDS1_uc003hua.3_Missense_Mutation_p.V360L	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	451							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GGAGCGTTTGGTGGAATGGTG	0.433			NA	T	NUP98	T-ALL								22	30					3.62473e-10	4.67225e-10	0.012319	1	0
RAP1GDS1	5910	broad.mit.edu	37	4	99342458	99342458	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:99342458G>T	uc003htx.3	+	12	1543	c.1353G>T	c.(1351-1353)GTG>GTT	p.V451V	RAP1GDS1_uc003htw.3_Silent_p.V452V|RAP1GDS1_uc003htv.3_Silent_p.V451V|RAP1GDS1_uc003htz.3_Silent_p.V402V|RAP1GDS1_uc003hty.3_Silent_p.V403V|RAP1GDS1_uc003hua.3_Silent_p.V360V	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	451							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		AGCGTTTGGTGGAATGGTGTG	0.433			NA	T	NUP98	T-ALL								23	30					6.44725e-10	8.2349e-10	0.002299	1	0
ANK2	287	broad.mit.edu	37	4	114117535	114117535	+	Missense_Mutation	SNP	C	C	A	rs146964054	byFrequency	TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:114117535C>A	uc003ibe.3	+	3	298	c.198C>A	c.(196-198)AAC>AAA	p.N66K	ANK2_uc003ibd.3_Missense_Mutation_p.N45K|ANK2_uc003ibf.3_Missense_Mutation_p.N66K|ANK2_uc003ibc.2_Missense_Mutation_p.N42K|ANK2_uc011cgb.1_Missense_Mutation_p.N81K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	66	ANK 2.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATGGACTCAACGCTCTCCATC	0.483			NA											13	31					4.3838e-07	5.30969e-07	0.001855	1	0
MAML3	55534	broad.mit.edu	37	4	141074131	141074131	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:141074131G>A	uc003ihz.1	-	1	1103	c.351C>T	c.(349-351)ACC>ACT	p.T117T	MAML3_uc011chd.1_Silent_p.T117T	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	117					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					TCTGCTCCAGGGTCCGCTGGT	0.672			NA											12	9					0	0	0.010729	0	0
ODZ3	55714	broad.mit.edu	37	4	183713606	183713606	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr4:183713606C>T	uc003ivd.1	+	25	5818	c.5781C>T	c.(5779-5781)GAC>GAT	p.D1927D		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1927	Extracellular (Potential).|YD 8.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCATCACGGACTACAACGAGG	0.502			NA											30	40					0	0	0.007291	0	0
CDH10	1008	broad.mit.edu	37	5	24537633	24537633	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:24537633G>T	uc003jgr.1	-	3	714	c.382C>A	c.(382-384)CGC>AGC	p.R128S	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	128	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GCTTGTGCGCGTAGAGTATAA	0.413			NA								HNSCC(23;0.051)			51	108					6.3237e-29	1.11758e-28	0.00361	1	0
CDH6	1004	broad.mit.edu	37	5	31323074	31323074	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:31323074A>G	uc003jhe.1	+	12	2358	c.2032A>G	c.(2032-2034)AGG>GGG	p.R678G		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	678	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CGGCACCCTGAGGAATCCTGA	0.502			NA											4	74					0	0	0.009096	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33614470	33614470	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:33614470C>A	uc003jia.1	-	16	2563	c.2400G>T	c.(2398-2400)CAG>CAT	p.Q800H	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q715H	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	800	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGTTAGTCACCTGGAATAGAA	0.438			NA								HNSCC(64;0.19)			15	25					7.05477e-17	1.07156e-16	0.00499	1	0
HCN1	348980	broad.mit.edu	37	5	45262155	45262155	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:45262155C>A	uc003jok.2	-	8	2566	c.2541G>T	c.(2539-2541)TCG>TCT	p.S847S		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	847	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GGATGGCTCCCGACGACATCT	0.647			NA											36	81					1.47197e-15	2.17697e-15	0.007835	1	0
HCN1	348980	broad.mit.edu	37	5	45267293	45267293	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:45267293G>T	uc003jok.2	-	7	1706	c.1681C>A	c.(1681-1683)CTT>ATT	p.L561I		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	561	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGTGAGTAAAGACGACAATAT	0.428			NA											28	56					1.38267e-23	2.2721e-23	0.005443	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128862046	128862046	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:128862046C>A	uc003kvb.1	+	4	965	c.965C>A	c.(964-966)CCT>CAT	p.P322H	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	322					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TACAAATTACCTCAAGAATAC	0.388			NA											7	61					0.00198382	0.00216908	0.001984	1	0
PCDHA7	56141	broad.mit.edu	37	5	140215250	140215250	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:140215250C>T	uc003lhq.2	+	1	1282	c.1282C>T	c.(1282-1284)CGG>TGG	p.R428W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.R428W	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	428	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTACCGCGCGGGACGGGGG	0.617	NSCLC(160;258 2013 5070 22440 28951)		NA											75	130					0	0	0.00361	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516961	140516961	+	Missense_Mutation	SNP	C	C	T	rs17844424		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:140516961C>T	uc003liq.2	+	1	2162	c.1945C>T	c.(1945-1947)CCT>TCT	p.P649S		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	649	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATGGCGAGCCTCCGCGCTC	0.731			NA											36	57					0	0	0.003271	0	0
PCDHB6	56130	broad.mit.edu	37	5	140529963	140529963	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:140529963C>A	uc003lir.2	+	1	125	c.125C>A	c.(124-126)ACG>AAG	p.T42K	PCDHB6_uc011dah.1_Intron	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	42	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAAGTGGCACGTTTGTGGCC	0.502			NA											48	78					2.81731e-22	4.54979e-22	0.00361	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140710439	140710439	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:140710439G>T	uc003lji.1	+	1	188	c.188G>T	c.(187-189)GGA>GTA	p.G63V	PCDHGA1_uc011dan.1_Missense_Mutation_p.G63V	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	63	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATGGCGGAGTCCGCATC	0.572			NA											67	98					7.75977e-34	1.45366e-33	0.00361	1	0
PCDHGA11	56105	broad.mit.edu	37	5	140801564	140801564	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:140801564G>T	uc003lkq.1	+	1	1028	c.770G>T	c.(769-771)AGC>ATC	p.S257I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.S257I|PCDHGA11_uc003lkp.1_Missense_Mutation_p.S257I	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	257	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAACATCAGCTCCGGAACT	0.483			NA											65	138					1.02487e-32	1.89466e-32	0.00361	1	0
SLC36A3	285641	broad.mit.edu	37	5	150657178	150657178	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:150657178G>A	uc003ltw.2	-	10	1608	c.1189C>T	c.(1189-1191)CTG>TTG	p.L397L	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.L382L|SLC36A3_uc003ltx.2_Silent_p.L438L	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	397	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGCCTACCAGGGAGATGACC	0.532			NA											26	43					0	0	0.00632	0	0
KIF4B	285643	broad.mit.edu	37	5	154395153	154395153	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:154395153G>T	uc010jih.1	+	1	1894	c.1734G>T	c.(1732-1734)TTG>TTT	p.L578F		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	578	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGGAAGAATTGGTTCGTGAAC	0.423			NA											26	63					1.42536e-11	1.88927e-11	0.004656	1	0
KIF4B	285643	broad.mit.edu	37	5	154396937	154396937	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:154396937G>T	uc010jih.1	+	1	3678	c.3518G>T	c.(3517-3519)TGT>TTT	p.C1173F		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1173	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAAGAGATGTGTGACATGGAG	0.507			NA											22	60					8.10497e-08	9.9454e-08	0.010504	1	0
STC2	8614	broad.mit.edu	37	5	172755182	172755182	+	Silent	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:172755182C>A	uc003mco.1	-	1	1325	c.15G>T	c.(13-15)CGG>CGT	p.R5R	STC2_uc003mcn.1_5'Flank	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	5					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ACTGGCCCAGCCGCTCGGCAC	0.517			NA											57	106					1.45723e-30	2.65897e-30	0.00361	1	0
CDYL	9425	broad.mit.edu	37	6	4716036	4716036	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:4716036G>T	uc003mwi.2	+	2	155	c.24G>T	c.(22-24)AGG>AGT	p.R8S		NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	8					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CAAGCCACAGGTCAGCCTGGG	0.448			NA											23	9					1.10513e-12	1.48585e-12	0.002299	1	0
FAM65B	9750	broad.mit.edu	37	6	24843714	24843714	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:24843714G>T	uc003neo.1	-	14	1472	c.1296C>A	c.(1294-1296)AGC>AGA	p.S432R	FAM65B_uc011djs.1_Missense_Mutation_p.S411R|FAM65B_uc011dju.1_Missense_Mutation_p.S416R|FAM65B_uc003nep.2_Missense_Mutation_p.S382R|FAM65B_uc011djt.1_Missense_Mutation_p.S382R	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	432					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						GGTCACTGAAGCTGAGCGACA	0.478			NA											38	10					9.8876e-21	1.56973e-20	0.004878	1	0
TRIM39	56658	broad.mit.edu	37	6	30297471	30297471	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:30297471G>C	uc010jrz.2	+	3	689	c.377G>C	c.(376-378)TGC>TCC	p.C126S	HCG18_uc003npx.2_5'Flank|HCG18_uc003npy.2_5'Flank|TRIM39_uc003npz.2_Missense_Mutation_p.C126S|TRIM39_uc003nqb.2_Missense_Mutation_p.C126S|TRIM39_uc003nqc.2_Missense_Mutation_p.C126S|TRIM39_uc010jsa.1_Missense_Mutation_p.C126S	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	126	B box-type.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						GAGGCTGTATGCTTGATATGT	0.577			NA											55	23					0	0	0.00361	0	0
ABCF1	23	broad.mit.edu	37	6	30545863	30545863	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:30545863A>G	uc003nql.2	+	4	322	c.227A>G	c.(226-228)AAG>AGG	p.K76R	ABCF1_uc003nqk.2_Missense_Mutation_p.K77R|ABCF1_uc003nqm.2_Missense_Mutation_p.K76R|ABCF1_uc010jsb.2_Missense_Mutation_p.K76R	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	76					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						CAAAAAAAAAAGCGAGATACC	0.493			NA											29	68					0	0	0.00632	0	0
TCP11	6954	broad.mit.edu	37	6	35090040	35090040	+	Missense_Mutation	SNP	C	C	A	rs142915532	byFrequency	TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:35090040C>A	uc003okd.2	-	5	652	c.471G>T	c.(469-471)TTG>TTT	p.L157F	TCP11_uc003ojz.1_Missense_Mutation_p.L82F|TCP11_uc003oka.2_Missense_Mutation_p.L82F|TCP11_uc003okb.2_Missense_Mutation_p.L81F|TCP11_uc003okc.2_Missense_Mutation_p.L81F|TCP11_uc011dsu.1_Missense_Mutation_p.L139F|TCP11_uc011dsv.1_Missense_Mutation_p.L106F|TCP11_uc011dsw.1_Missense_Mutation_p.L111F	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	144					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						CCTGCTTGAGCAAGTCCATGT	0.488			NA											68	36					2.26907e-38	4.3973e-38	0.00361	1	0
FGD2	221472	broad.mit.edu	37	6	36976674	36976674	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:36976674C>A	uc010jwp.1	+	2	304	c.133C>A	c.(133-135)CCT>ACT	p.P45T	FGD2_uc003onf.2_Missense_Mutation_p.P45T|FGD2_uc011dtu.1_Missense_Mutation_p.P45T|FGD2_uc003ong.2_5'UTR|FGD2_uc011dtv.1_5'UTR	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	45					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						TGAGTGCAGGCCTCCCGAGTC	0.632			NA											39	24					5.04308e-16	7.5781e-16	0.00623	1	0
TDRD6	221400	broad.mit.edu	37	6	46658781	46658781	+	Silent	SNP	A	A	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:46658781A>T	uc003oyj.2	+	1	2916	c.2916A>T	c.(2914-2916)CTA>CTT	p.L972L	TDRD6_uc010jze.2_Silent_p.L966L	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	972					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTGTTCAGCTACATTCCTACT	0.388			NA											40	18					0	0	0.010771	0	0
MCM3	4172	broad.mit.edu	37	6	52143587	52143587	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:52143587C>T	uc003pan.1	-	6	942	c.832G>A	c.(832-834)GCT>ACT	p.A278T	MCM3_uc011dwu.1_Missense_Mutation_p.A232T	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	278					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					ATATCCTCAGCAGAGAAAGAG	0.438			NA											41	19					0	0	0.010771	0	0
PRIM2	5558	broad.mit.edu	37	6	57183296	57183296	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:57183296G>T	uc003pdx.2	+	2	140	c.53G>T	c.(52-54)AGG>ATG	p.R18M	PRIM2_uc003pdv.1_Missense_Mutation_p.R18M|PRIM2_uc003pdw.2_Missense_Mutation_p.R18M	NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	18					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GGTGACCAGAGGAATGCTTCC	0.398			NA											9	13					2.17888e-05	2.4393e-05	0.006214	1	0
PHIP	55023	broad.mit.edu	37	6	79697925	79697925	+	Splice_Site	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:79697925C>T	uc003pir.2	-	21	2686	c.2460_splice	c.e21+1	p.D820_splice	PHIP_uc011dyp.1_Splice_Site_p.D819_splice	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein						insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TGATATCTTACATCTGAAGAA	0.318			NA											10	65					0	0	0.001368	0	0
C6orf165	154313	broad.mit.edu	37	6	88138502	88138502	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:88138502G>A	uc003plv.2	+	9	1211	c.1119G>A	c.(1117-1119)GCG>GCA	p.A373A	C6orf165_uc003plw.2_Silent_p.A185A|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Silent_p.A373A	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	373										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TTAATGGAGCGACTGTGAAAA	0.368			NA											27	34					0	0	0.005443	0	0
CLVS2	134829	broad.mit.edu	37	6	123318960	123318960	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:123318960T>A	uc003pzi.1	+	2	907	c.38T>A	c.(37-39)CTG>CAG	p.L13Q		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	13					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CCTGAGACCCTGGAGAAAGCT	0.537			NA											15	38					0	0	0.004007	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135239695	135239695	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:135239695C>A	uc003qew.2	-	7	1375	c.1322G>T	c.(1321-1323)GGC>GTC	p.G441V	ALDH8A1_uc003qex.2_Missense_Mutation_p.G387V|ALDH8A1_uc010kgh.2_Missense_Mutation_p.G219V|ALDH8A1_uc011ecx.1_Missense_Mutation_p.G391V	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	441					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		CCAGACCAAGCCAGACTGCAG	0.562			NA											15	30					2.23348e-06	2.61504e-06	0.004007	1	0
WIPI2	26100	broad.mit.edu	37	7	5256250	5256250	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:5256250G>A	uc003snv.2	+	5	654	c.438G>A	c.(436-438)AAG>AAA	p.K146K	WIPI2_uc003snw.2_Silent_p.K146K|WIPI2_uc003snx.2_Silent_p.K128K|WIPI2_uc003sny.2_Silent_p.K128K|WIPI2_uc010ksv.2_Silent_p.K2K|WIPI2_uc003snz.2_Silent_p.K87K|WIPI2_uc003soa.2_Silent_p.K87K	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	146					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		GGGACATGAAGGTGCTGCATA	0.498			NA											33	102					0	0	0.006999	0	0
MIOS	54468	broad.mit.edu	37	7	7622753	7622753	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:7622753G>C	uc003srf.2	+	6	1706	c.1398G>C	c.(1396-1398)ATG>ATC	p.M466I	MIOS_uc003srg.2_Missense_Mutation_p.M1I|MIOS_uc010ktq.2_5'Flank	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	466											0						TTTTAGGAATGGTGGAAAGCA	0.303			NA											20	80					0	0	0.007413	0	0
KLHL7	55975	broad.mit.edu	37	7	23163444	23163444	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:23163444G>T	uc003svs.3	+	2	462	c.169G>T	c.(169-171)GCT>TCT	p.A57S	KLHL7_uc003svr.3_Missense_Mutation_p.A35S|KLHL7_uc011jys.1_Intron|KLHL7_uc011jyt.1_Intron|KLHL7_uc003svt.2_Missense_Mutation_p.A9S|KLHL7_uc003svp.2_Missense_Mutation_p.A35S|KLHL7_uc003svq.2_Missense_Mutation_p.A57S|KLHL7_uc011jyu.1_Missense_Mutation_p.A35S	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	57	BTB.					Golgi apparatus|nucleolus|plasma membrane					0						AAAGATACCTGCTCATCGTGT	0.358			NA											25	65					4.87955e-14	6.89022e-14	0.005443	1	0
IGF2BP3	10643	broad.mit.edu	37	7	23387344	23387344	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:23387344G>T	uc003swg.2	-	7	959	c.693C>A	c.(691-693)GTC>GTA	p.V231V	IGF2BP3_uc003swf.2_5'UTR	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	231	KH 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						CTTTACGGTGGACATCGATTC	0.478			NA											28	127					3.99451e-17	6.10031e-17	0.009535	1	0
BBS9	27241	broad.mit.edu	37	7	33573735	33573735	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:33573735G>T	uc003tdn.1	+	21	2981	c.2468G>T	c.(2467-2469)GGC>GTC	p.G823V	BBS9_uc003tdo.1_Missense_Mutation_p.G788V|BBS9_uc003tdp.1_Missense_Mutation_p.G818V|BBS9_uc003tdq.1_Missense_Mutation_p.G783V|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.G347V|BBS9_uc003tds.1_Missense_Mutation_p.G246V|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	823					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TCCAAAGGTGGCCGTCTCTGC	0.493			NA							Bardet-Biedl_syndrome				34	56					1.45844e-13	2.02881e-13	0.002836	1	0
DPY19L2P1	554236	broad.mit.edu	37	7	35144371	35144371	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:35144371G>T	uc003teq.1	-	18	1844	c.737C>A	c.(736-738)GCT>GAT	p.A246D	DPY19L2P1_uc003tep.1_RNA|DPY19L2P1_uc010kwz.1_RNA					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						TGTGTGAAAAGCCAGCTATAA	0.308			NA											19	55					6.94344e-10	8.82854e-10	0.006122	1	0
EEPD1	80820	broad.mit.edu	37	7	36194118	36194118	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:36194118G>T	uc003tfa.2	+	2	825	c.185G>T	c.(184-186)CGC>CTC	p.R62L		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	62	HhH.				DNA repair		DNA binding				0						GCCGTGGCACGCAGCATCGTG	0.577			NA											226	67					1.5621e-98	3.30037e-98	0.00361	1	0
PKD1L1	168507	broad.mit.edu	37	7	47906168	47906168	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:47906168C>T	uc003tny.1	-	25	3941	c.3941G>A	c.(3940-3942)GGG>GAG	p.G1314E		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1314	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TGTGTAACTCCCCATCAGCTG	0.443			NA											32	96					0	0	0.010818	0	0
ABCA13	154664	broad.mit.edu	37	7	48411995	48411995	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:48411995G>T	uc003toq.2	+	33	11059	c.11034G>T	c.(11032-11034)GCG>GCT	p.A3678A	ABCA13_uc010kys.1_Silent_p.A752A|ABCA13_uc003tos.1_Silent_p.A504A	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3678					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTAATACAGCGGCCCTTTGTA	0.413			NA											104	333					1.04275e-50	2.12327e-50	0.00361	1	0
NSUN5P2	260294	broad.mit.edu	37	7	72419892	72419892	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:72419892C>T	uc003twn.2	-	8	1054	c.342G>A	c.(340-342)GAG>GAA	p.E114E	POM121_uc010lam.1_3'UTR|NSUN5P2_uc003twl.2_RNA|NSUN5P2_uc003twm.2_Silent_p.E114E|NSUN5P2_uc003two.2_Silent_p.E114E|NSUN5P2_uc003twq.2_Silent_p.E114E|NSUN5P2_uc010lan.1_Intron|NSUN5P2_uc003twp.2_Silent_p.E114E	NM_032158	NP_115534			NOL1/NOP2/Sun domain family, member 5C isoform												0						CATAGTGGACCTCACGATAGC	0.622			NA											9	19					0	0	0.008291	0	0
PCLO	27445	broad.mit.edu	37	7	82387975	82387975	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:82387975G>T	uc003uhx.2	-	25	15634	c.15345C>A	c.(15343-15345)GCC>GCA	p.A5115A		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	5038	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCCAGATACAGGCTTCACCAA	0.343			NA											88	86					6.16549e-39	1.20313e-38	0.00361	1	0
ZNF804B	219578	broad.mit.edu	37	7	88966128	88966128	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:88966128C>A	uc011khi.1	+	4	4370	c.3832C>A	c.(3832-3834)CCA>ACA	p.P1278T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1278						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CCCCTTCCACCCATCTCACAT	0.463			NA								HNSCC(36;0.09)			52	155					1.91693e-13	2.65348e-13	0.00361	1	0
PCOLCE	5118	broad.mit.edu	37	7	100205337	100205337	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:100205337T>C	uc003uvo.2	+	8	1288	c.1090T>C	c.(1090-1092)TAT>CAT	p.Y364H	PCOLCE_uc010lhb.1_RNA|PCOLCE_uc003uvp.1_RNA	NM_002593	NP_002584	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	364	NTR.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity				0	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TATTGGTGCTTATAAAACTGG	0.557			NA											22	91					0	0	0.00632	0	0
SND1	27044	broad.mit.edu	37	7	127334986	127334986	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:127334986G>T	uc003vmi.2	+	3	559	c.333G>T	c.(331-333)ATG>ATT	p.M111I		NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	111	TNase-like 1.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						AGTATGGCATGATCTACCTTG	0.478			NA											19	70					5.35267e-07	6.45536e-07	0.007413	1	0
FAM180A	389558	broad.mit.edu	37	7	135418891	135418891	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:135418891G>T	uc003vtd.2	-	3	620	c.354C>A	c.(352-354)CTC>CTA	p.L118L	FAM180A_uc010lmt.2_RNA|FAM180A_uc010lmu.2_Silent_p.L118L	NM_205855	NP_995327	Q6UWF9	F180A_HUMAN	hypothetical protein LOC389558 precursor	118						extracellular region				ovary(2)	2						CTTCTTTCTTGAGGATGCCAG	0.612			NA											56	56					3.84483e-29	6.83796e-29	0.00361	1	0
DENND2A	27147	broad.mit.edu	37	7	140301269	140301269	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:140301269G>C	uc010lnj.2	-	1	1074	c.929C>G	c.(928-930)TCT>TGT	p.S310C	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S310C|DENND2A_uc003vvw.2_Missense_Mutation_p.S310C|DENND2A_uc003vvx.2_Missense_Mutation_p.S310C	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	310								p.S310A(1)		ovary(3)|breast(1)	4	Melanoma(164;0.00956)					aggtgggggagaggagggcag	0.398			NA											28	39					0	0	0.003271	0	0
TRYX3	136541	broad.mit.edu	37	7	141952343	141952343	+	Silent	SNP	C	C	T	rs150069777		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:141952343C>T	uc003vxb.2	-	4	845	c.525G>A	c.(523-525)ACG>ACA	p.T175T	TRYX3_uc003vxc.3_Silent_p.T175T	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	175	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					GCATATTTTCCGTGATGTTGT	0.433			NA											24	92					0	0	0.003954	0	0
ZNF746	155061	broad.mit.edu	37	7	149174757	149174757	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:149174757C>A	uc003wfw.2	-	5	881	c.610G>T	c.(610-612)GTG>TTG	p.V204L	ZNF746_uc010lpi.2_Missense_Mutation_p.V204L	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	204					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CACGCCTCCACGCCCAGGGCC	0.672			NA											11	20					3.86212e-05	4.28955e-05	0.008291	1	0
ZNF467	168544	broad.mit.edu	37	7	149461930	149461930	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr7:149461930C>A	uc003wgd.2	-	5	1802	c.1661G>T	c.(1660-1662)CGC>CTC	p.R554L	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	554	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTGGGTCTTGCGGCTGAAGCT	0.706			NA											26	24					1.08312e-15	1.61035e-15	0.009535	1	0
RP1L1	94137	broad.mit.edu	37	8	10470400	10470400	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:10470400G>T	uc003wtc.2	-	4	1437	c.1208C>A	c.(1207-1209)CCC>CAC	p.P403H		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	403					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TTCATACTTGGGCCCTGGCTG	0.667			NA											30	50					7.26314e-15	1.05748e-14	0.007291	1	0
MTMR9	66036	broad.mit.edu	37	8	11177238	11177238	+	Silent	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:11177238C>T	uc003wtm.2	+	9	1775	c.1377C>T	c.(1375-1377)TCC>TCT	p.S459S	MTMR9_uc010lrx.2_Silent_p.S352S|MTMR9_uc011kxa.1_Silent_p.S374S|uc003wtn.1_RNA	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	459	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		CTTTGTGGTCCTGGGTTAATC	0.423			NA											36	58					0	0	0.004289	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532360	40532360	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:40532360C>A	uc003xnr.2	-	5	586	c.440G>T	c.(439-441)TGT>TTT	p.C147F	ZMAT4_uc003xns.2_Intron	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	147	Matrin-type 3.					nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			ACAGAGCCCACAGTATCTGTC	0.498			NA											116	201					5.16181e-52	1.05874e-51	0.00361	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75898471	75898471	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:75898471G>A	uc003yan.2	+	2	624	c.249G>A	c.(247-249)ATG>ATA	p.M83I		NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	83						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			CCTCTAATATGGAGTATATGG	0.358			NA											51	46					0	0	0.00361	0	0
RIMS2	9699	broad.mit.edu	37	8	104898392	104898392	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:104898392C>A	uc003yls.2	+	2	1140	c.899C>A	c.(898-900)ACG>AAG	p.T300K	RIMS2_uc003ylp.2_Missense_Mutation_p.T522K|RIMS2_uc003ylw.2_Missense_Mutation_p.T330K|RIMS2_uc003ylq.2_Missense_Mutation_p.T330K|RIMS2_uc003ylr.2_Missense_Mutation_p.T330K	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	553					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTGGCTTCCACGCCTGAATAT	0.403			NA								HNSCC(12;0.0054)			8	25					1.76689e-08	2.18721e-08	0.006214	1	0
LRP12	29967	broad.mit.edu	37	8	105503016	105503016	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:105503016C>A	uc003yma.2	-	7	2560	c.2465G>T	c.(2464-2466)CGA>CTA	p.R822L	LRP12_uc003ymb.2_Missense_Mutation_p.R803L|LRP12_uc003ylz.2_Missense_Mutation_p.R228L	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	822	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GGGGCCATCTCGATTACTTGG	0.468			NA											14	52					4.3838e-07	5.30969e-07	0.001855	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110516570	110516570	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:110516570G>T	uc003yne.2	+	68	10947	c.10843G>T	c.(10843-10845)GGA>TGA	p.G3615*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3615	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AACATTTGTTGGATTTAAGAA	0.284			NA								HNSCC(38;0.096)			4	44					0.00024832	0.000274716	0.009096	1	0
FER1L6	654463	broad.mit.edu	37	8	125025722	125025723	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:125025722_125025723CC>AA	uc003yqw.2	+	15	2079_2080	c.1873_1874CC>AA	c.(1873-1875)CCT>AAT	p.P625N	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	625	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACAGGAGGCACCTGAAGAGAAA	0.49			NA											26	47					0	0	0.004672	0	0
EPPK1	83481	broad.mit.edu	37	8	144947001	144947001	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr8:144947001C>T	uc003zaa.1	-	1	434	c.421G>A	c.(421-423)GTT>ATT	p.V141I		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	141	Plectin 3.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGTCCACAACCTCCTTCCCG	0.682			NA											9	30					0	0	0.006214	0	0
PTPRD	5789	broad.mit.edu	37	9	8636710	8636710	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr9:8636710G>C	uc003zkk.2	-	12	910	c.199C>G	c.(199-201)CAG>GAG	p.Q67E	PTPRD_uc003zkp.2_Missense_Mutation_p.Q67E|PTPRD_uc003zkq.2_Missense_Mutation_p.Q67E|PTPRD_uc003zkr.2_Missense_Mutation_p.Q67E|PTPRD_uc003zks.2_Missense_Mutation_p.Q67E|PTPRD_uc003zkl.2_Missense_Mutation_p.Q67E|PTPRD_uc003zkm.2_Missense_Mutation_p.Q67E|PTPRD_uc003zkn.2_Missense_Mutation_p.Q67E|PTPRD_uc003zko.2_Missense_Mutation_p.Q67E|PTPRD_uc003zkt.1_Missense_Mutation_p.Q67E	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	67	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCAAATCTCTGATTGCTGACT	0.443			NA								TSP Lung(15;0.13)			26	69					0	0	0.003954	0	0
CTSL2	1515	broad.mit.edu	37	9	99799533	99799533	+	Splice_Site	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr9:99799533C>A	uc004awt.2	-	4	593	c.396_splice	c.e4+1	p.Q132_splice	CTSL2_uc010msi.2_Splice_Site_p.Q132_splice|CTSL2_uc004awu.2_Splice_Site_p.Q77_splice|CTSL2_uc010msj.1_Splice_Site_p.Q77_splice|CTSL2_uc010msk.2_Splice_Site_p.Q77_splice	NM_001333	NP_001324	O60911	CATL2_HUMAN	cathepsin L2 preproprotein							lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(62;0.0559)				CGCTGTCTCACCTGATTCTTC	0.483			NA											16	27					1.5739e-10	2.04752e-10	0.004007	1	0
IKBKAP	8518	broad.mit.edu	37	9	111663784	111663784	+	Silent	SNP	T	T	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr9:111663784T>A	uc004bdm.3	-	18	2455	c.1935A>T	c.(1933-1935)GCA>GCT	p.A645A	IKBKAP_uc004bdl.2_Silent_p.A296A|IKBKAP_uc011lwc.1_Silent_p.A531A|IKBKAP_uc010mtq.2_Silent_p.A296A	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	645					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						CATCATATACTGCAAATGACG	0.408			NA											12	26					0	0	0.001368	0	0
SPTAN1	6709	broad.mit.edu	37	9	131347078	131347078	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr9:131347078G>A	uc004bvl.3	+	18	2629	c.2516G>A	c.(2515-2517)CGC>CAC	p.R839H	SPTAN1_uc011mbg.1_Missense_Mutation_p.R839H|SPTAN1_uc011mbh.1_Missense_Mutation_p.R851H|SPTAN1_uc004bvm.3_Missense_Mutation_p.R839H|SPTAN1_uc004bvn.3_Missense_Mutation_p.R839H	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	839	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CATGAACCACGCATCAAAGCA	0.488	NSCLC(120;833 1744 2558 35612 37579)		NA											29	41					0	0	0.009535	0	0
NUP188	23511	broad.mit.edu	37	9	131745599	131745599	+	Silent	SNP	G	G	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr9:131745599G>A	uc004bws.1	+	18	1846	c.1824G>A	c.(1822-1824)GTG>GTA	p.V608V	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	608					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						CCCCACCTGTGGATGTCATTG	0.438			NA											52	137					0	0	0.00361	0	0
SCML2	10389	broad.mit.edu	37	X	18278317	18278317	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chrX:18278317C>A	uc004cyl.2	-	9	1200	c.1043G>T	c.(1042-1044)GGG>GTG	p.G348V	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.G348V|SCML2_uc011miz.1_Missense_Mutation_p.G282V|SCML2_uc010nfc.2_Missense_Mutation_p.G84V	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	348					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					TTTACATGGCCCAGAAGCGAC	0.353	Esophageal Squamous(100;1252 1965 19021 35517)		NA											27	15					9.65021e-13	1.31e-12	0.010818	1	0
CAPN6	827	broad.mit.edu	37	X	110496280	110496280	+	Silent	SNP	G	G	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chrX:110496280G>T	uc004epc.1	-	4	630	c.462C>A	c.(460-462)TCC>TCA	p.S154S	CAPN6_uc011msu.1_5'UTR	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	154	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						ACTCATTCATGGAAGTGGAGA	0.433			NA											40	13					1.47244e-24	2.44827e-24	0.00623	1	0
ENOX2	10495	broad.mit.edu	37	X	129837188	129837188	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chrX:129837188C>A	uc004evw.2	-	5	508	c.90G>T	c.(88-90)ATG>ATT	p.M30I	ENOX2_uc004evx.2_Missense_Mutation_p.M1I|ENOX2_uc004evy.2_Missense_Mutation_p.M1I	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	30					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						TAGGTAGTGTCATTGCAGTGG	0.418	Ovarian(101;828 1506 2951 9500 35258)		NA											54	13					1.93748e-29	3.46772e-29	0.00361	1	0
PROX1	5629	broad.mit.edu	37	1	214171394	214171394	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr1:214171394delG	uc001hkh.2	+	2	1788	c.1516delG	c.(1516-1518)GGAfs	p.G506fs	PROX1_uc001hkg.1_Frame_Shift_Del_p.G506fs	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	506					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTCCTTCTCTGGAAAAGACAG	0.557			NA											98	65	---	---	---	---	NA	NA	NA	NA	NA
FAM119B	25895	broad.mit.edu	37	12	58174037	58174037	+	Splice_Site	DEL	G	G	-	rs143311691		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr12:58174037delG	uc001sqg.2	+	3	415	c.290_splice	c.e3-1	p.G97_splice	FAM119B_uc001sqf.2_Splice_Site_p.R143_splice|FAM119B_uc009zqd.2_Splice_Site|TSFM_uc001sqi.2_5'Flank|TSFM_uc010sse.1_5'Flank|TSFM_uc001sqh.2_5'Flank|TSFM_uc010ssf.1_5'Flank	NM_015433	NP_056248	Q96AZ1	MT21B_HUMAN	hypothetical protein LOC25895 isoform a							integral to membrane|intracellular	methyltransferase activity				0	all_cancers(7;9.07e-82)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CTCTCTCTCAGGGGGGGATGT	0.582			NA											35	15	---	---	---	---	NA	NA	NA	NA	NA
ZIC2	7546	broad.mit.edu	37	13	100635008	100635010	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	CCA	CCA	-	-	CCA	CCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr13:100635008_100635010delCCA	uc001von.2	+	1	690_692	c.690_692delCCA	c.(688-693)GCCCAC>GCC	p.H239del		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	239	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).|Poly-His.		Missing.|H -> HH.		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAGCCGCGGCccaccaccaccac	0.522	Pancreas(97;119 1522 31925 44771 48764)		NA											7	92	---	---	---	---	NA	NA	NA	NA	NA
ARHGEF15	22899	broad.mit.edu	37	17	8215575	8215576	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr17:8215575_8215576insT	uc002glc.2	+	2	339_340	c.218_219insT	c.(217-219)CCTfs	p.P73fs	ARHGEF15_uc002glb.1_Frame_Shift_Ins_p.P73fs|ARHGEF15_uc002gld.2_Frame_Shift_Ins_p.P73fs|ARHGEF15_uc010vuw.1_Frame_Shift_Ins_p.P73fs	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	73	Pro-rich.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CTCAAGCCCCCTGCTCTTTTGC	0.614			NA											35	31	---	---	---	---	NA	NA	NA	NA	NA
CD226	10666	broad.mit.edu	37	18	67614136	67614136	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr18:67614136delC	uc010dqo.2	-	2	663	c.216delG	c.(214-216)AGGfs	p.R72fs	CD226_uc002lkm.3_Frame_Shift_Del_p.R72fs	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	72	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				CATAGGGCTTCCTTATGACCA	0.453	NSCLC(184;838 2130 8673 21498 50749)		NA											42	44	---	---	---	---	NA	NA	NA	NA	NA
STK11	6794	broad.mit.edu	37	19	1220663	1220676	+	Frame_Shift_Del	DEL	CCTGGACACCTTCT	CCTGGACACCTTCT	-			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	CCTGGACACCTTCT	CCTGGACACCTTCT	-	-	CCTGGACACCTTCT	CCTGGACACCTTCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr19:1220663_1220676delCCTGGACACCTTCT	uc002lrl.1	+	5	1796_1809	c.681_694delCCTGGACACCTTCT	c.(679-696)GGCCTGGACACCTTCTCCfs	p.G227fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	227_232	Protein kinase.		S -> P (in sporadic cancer; somatic mutation; no effect heterotrimeric complex assembly with STRADA and CAB39).		anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(2)|p.F231L(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGCCAACGGCCTGGACACCTTCTCCGGCTTCAA	0.701			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			17	12	---	---	---	---	NA	NA	NA	NA	NA
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	G	-	rs138961929		TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr20:4850569delG	uc002wlg.1	-	12	1608	c.1233delC	c.(1231-1233)CCCfs	p.P411fs	SLC23A2_uc010zqr.1_Frame_Shift_Del_p.P296fs|SLC23A2_uc002wlh.1_Frame_Shift_Del_p.P411fs|SLC23A2_uc002wli.2_Frame_Shift_Del_p.P410fs	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						TTGCGTGGATGGGGGGGGGTG	0.527			NA											11	139	---	---	---	---	NA	NA	NA	NA	NA
C3orf19	51244	broad.mit.edu	37	3	14712602	14712603	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr3:14712602_14712603insA	uc003byw.2	+	11	1396_1397	c.1305_1306insA	c.(1303-1308)CATACGfs	p.H435fs	C3orf19_uc010hej.2_Frame_Shift_Ins_p.H264fs	NM_016474	NP_057558	Q6PII3	CC019_HUMAN	hypothetical protein LOC51244	435_436											0						GCCCTGAACATACGTCACCCAC	0.55			NA											40	18	---	---	---	---	NA	NA	NA	NA	NA
ZNF608	57507	broad.mit.edu	37	5	123982754	123982762	+	In_Frame_Del	DEL	TACTTCTCA	TACTTCTCA	-			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	TACTTCTCA	TACTTCTCA	-	-	TACTTCTCA	TACTTCTCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr5:123982754_123982762delTACTTCTCA	uc003ktq.1	-	4	3438_3446	c.3315_3323delTGAGAAGTA	c.(3313-3324)TATGAGAAGTAC>TAC	p.1105_1108YEKY>Y	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_In_Frame_Del_p.1105_1108YEKY>Y|ZNF608_uc003ktt.1_In_Frame_Del_p.1105_1108YEKY>Y|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1105_1108						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GTCCTCATAGTACTTCTCATACTGCTGTC	0.522			NA											27	81	---	---	---	---	NA	NA	NA	NA	NA
HLA-F	3134	broad.mit.edu	37	6	29694802	29694803	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4415-01A-22D-1855-08	TCGA-05-4415-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	128f52c7-49dc-4a9f-a5bc-1c14684edc9c	1339361e-fe70-4584-a7cd-946ccd8476bc	g.chr6:29694802_29694803insT	uc003nno.3	+	7	1303_1304	c.1179_1180insT	c.(1177-1182)TTGTTTfs	p.L393fs	HLA-F_uc011dlx.1_Intron|HLA-F_uc011dly.1_Intron|LOC285830_uc003nnp.2_RNA|LOC285830_uc011dlz.1_RNA	NM_001098479	NP_001091949	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	Error:Variant_position_missing_in_P30511_after_alignment					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						TGTGGATCTTGTTTTTTTTGTG	0.535			NA											9	335	---	---	---	---	NA	NA	NA	NA	NA