Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARID1A	8289	broad.mit.edu	37	1	27056307	27056307	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr1:27056307C>T	uc001bmv.1	+	2	1676	c.1303C>T	c.(1303-1305)CAG>TAG	p.Q435*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q435*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q435*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q52*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	435					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GATGACCATGCAGGGCCGGGC	0.597			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								13	19					0	0	0.105934	0	0
DNA2	1763	broad.mit.edu	37	10	70192040	70192040	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr10:70192040C>T	uc001jof.2	-	12	2054	c.2054G>A	c.(2053-2055)CGT>CAT	p.R685H	DNA2_uc001jog.1_Missense_Mutation_p.R599H|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	599					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						CTGAGGTTCACGAAAGTCAAT	0.343			NA											33	102					0	0	0.173368	0	0
TMTC1	83857	broad.mit.edu	37	12	29670381	29670381	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr12:29670381C>G	uc001rjb.2	-	14	2298	c.1824G>C	c.(1822-1824)CAG>CAC	p.Q608H	TMTC1_uc001riz.2_Missense_Mutation_p.Q365H|TMTC1_uc001rja.2_Missense_Mutation_p.Q452H|TMTC1_uc001riy.2_Missense_Mutation_p.Q61H	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	716	TPR 7.					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GGAGCTCCCTCTGAGAAGGCT	0.507			NA											21	56					0	0	0.234183	0	0
LRP1	4035	broad.mit.edu	37	12	57572723	57572723	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr12:57572723T>G	uc001snd.2	+	28	5123	c.4657T>G	c.(4657-4659)TGT>GGT	p.C1553G		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1553	EGF-like 7.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTCCCACCTGTGTCTCATCAA	0.617			NA											27	67					0	0	0.099896	0	0
MPP5	64398	broad.mit.edu	37	14	67746041	67746041	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr14:67746041C>G	uc001xjc.2	+	3	620	c.154C>G	c.(154-156)CGA>GGA	p.R52G	MPP5_uc001xjd.2_Missense_Mutation_p.R18G|MPP5_uc001xjb.1_Missense_Mutation_p.R52G	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	52	Interaction with PARD6B (By similarity).				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		GCCAATACGTCGAAGTGCACA	0.478			NA											16	43					0	0	0.146539	0	0
THBS1	7057	broad.mit.edu	37	15	39880808	39880808	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr15:39880808T>G	uc001zkh.2	+	10	1732	c.1553T>G	c.(1552-1554)CTC>CGC	p.L518R	THBS1_uc010bbi.2_5'UTR	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	518	TSP type-1 3.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CGTAGTCGTCTCTGCAACAAC	0.522			NA											11	23					0	0	0.080935	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274214	10274214	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:10274214G>A	uc002czo.3	-	2	603	c.55C>T	c.(55-57)CGC>TGC	p.R19C	GRIN2A_uc010uym.1_Missense_Mutation_p.R19C|GRIN2A_uc002czr.3_Missense_Mutation_p.R19C|GRIN2A_uc010buk.2_Missense_Mutation_p.R19C	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	19					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCCGGACCGCGCCAGACCAGA	0.667			NA											5	27					0	0	0.217242	0	0
SNX29	92017	broad.mit.edu	37	16	12662416	12662416	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:12662416G>T	uc002dby.3	+	14	1273	c.1217G>T	c.(1216-1218)CGC>CTC	p.R406L		NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	406					cell communication		phosphatidylinositol binding			ovary(1)	1						GCAGCTTCCCGCTTCCCCAAA	0.637			NA											8	37					0.000274275	0.000284249	0.047766	1	0
CPPED1	55313	broad.mit.edu	37	16	12798545	12798545	+	Silent	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:12798545G>A	uc002dca.3	-	3	762	c.651C>T	c.(649-651)GAC>GAT	p.D217D	CPPED1_uc002dcb.3_Intron|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	217							hydrolase activity|metal ion binding				0						AGTAGTAGTCGTCGTCCTCGT	0.607			NA											23	58					0	0	0.099896	0	0
DNAH3	55567	broad.mit.edu	37	16	20996705	20996705	+	Silent	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:20996705G>A	uc010vbe.1	-	48	7359	c.7359C>T	c.(7357-7359)TAC>TAT	p.Y2453Y	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2453	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGTATAGCTCGTATGCGTTCA	0.552			NA											6	19					0	0	0.217242	0	0
ERN2	10595	broad.mit.edu	37	16	23716365	23716365	+	Silent	SNP	G	G	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:23716365G>T	uc002dma.3	-	8	1006	c.837C>A	c.(835-837)GGC>GGA	p.G279G	ERN2_uc010bxp.2_Silent_p.G279G|ERN2_uc010bxq.1_Silent_p.G87G	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	231	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGGTGTAGACGCCCATCACAG	0.677			NA											11	27					1.58986e-06	1.67819e-06	0.069234	1	0
ALDOA	226	broad.mit.edu	37	16	30078933	30078933	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:30078933G>A	uc002dvw.2	+	6	1403	c.275G>A	c.(274-276)CGT>CAT	p.R92H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ALDOA_uc002dvx.2_Missense_Mutation_p.R92H|ALDOA_uc002dvy.2_Missense_Mutation_p.R92H|ALDOA_uc002dvz.2_Missense_Mutation_p.R92H|ALDOA_uc002dwa.3_Missense_Mutation_p.R92H|ALDOA_uc002dwb.1_Missense_Mutation_p.R92H|ALDOA_uc002dwc.2_Missense_Mutation_p.R92H|ALDOA_uc010veg.1_Missense_Mutation_p.R146H|ALDOA_uc002dwd.2_Missense_Mutation_p.R92H	NM_184043	NP_908932	P04075	ALDOA_HUMAN	fructose-bisphosphate aldolase A	92					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			lung(1)	1						GATGATGGGCGTCCCTTCCCC	0.582			NA											19	51					0	0	0.234183	0	0
NECAB2	54550	broad.mit.edu	37	16	84035515	84035515	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:84035515G>A	uc002fhd.2	+	12	1143	c.1126G>A	c.(1126-1128)GTG>ATG	p.V376M	NECAB2_uc002fhe.2_Missense_Mutation_p.V293M	NM_019065	NP_061938	Q7Z6G3	NECA2_HUMAN	neuronal calcium-binding protein 2	376	ABM.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			ovary(2)	2						CAGGATCTTGGTGCCAGGTAG	0.637			NA											12	20					0	0	0.09319	0	0
PPP1R1B	84152	broad.mit.edu	37	17	37785471	37785471	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr17:37785471C>T	uc002hrz.2	+	2	597	c.130C>T	c.(130-132)CAC>TAC	p.H44Y	PPP1R1B_uc002hsa.2_Missense_Mutation_p.H44Y|PPP1R1B_uc010cvx.2_Missense_Mutation_p.H44Y|PPP1R1B_uc002hsb.2_Missense_Mutation_p.H8Y|PPP1R1B_uc002hsc.2_Missense_Mutation_p.H8Y	NM_032192	NP_115568	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	44					signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCTCTCAGAGCACTCCTCACC	0.637			NA											37	56					0	0	0.257332	0	0
DHX58	79132	broad.mit.edu	37	17	40257096	40257096	+	Silent	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr17:40257096G>A	uc002hyw.3	-	10	1564	c.1341C>T	c.(1339-1341)ATC>ATT	p.I447I	DHX58_uc002hyv.3_RNA|DHX58_uc010wgf.1_Silent_p.I440I	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	447	Helicase C-terminal.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGCAATGTGGGATGTCCAGCC	0.557			NA											4	41					0	0	0.217242	0	0
C18orf34	374864	broad.mit.edu	37	18	30928852	30928852	+	Splice_Site	SNP	A	A	G	rs140419270	byFrequency	TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr18:30928852A>G	uc002kxn.2	-	7	599	c.457_splice	c.e7+1	p.D153_splice	C18orf34_uc010xbr.1_Splice_Site_p.D153_splice|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Splice_Site_p.D153_splice|C18orf34_uc002kxp.2_Splice_Site_p.D153_splice	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1											ovary(1)	1						GAACAACTTTACCTCTCTTTT	0.323			NA											3	17					0	0	0.115264	0	0
COL5A3	50509	broad.mit.edu	37	19	10080323	10080323	+	Silent	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr19:10080323C>T	uc002mmq.1	-	56	4112	c.4026G>A	c.(4024-4026)ACG>ACA	p.T1342T		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1342	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCATTGGACCCGTCCTCCCTG	0.682			NA											5	19					0	0	0.184627	0	0
TEX101	83639	broad.mit.edu	37	19	43922333	43922333	+	Silent	SNP	G	G	A	rs151129496		TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr19:43922333G>A	uc010xwo.1	+	6	729	c.534G>A	c.(532-534)TCG>TCA	p.S178S	TEX101_uc002owk.2_Silent_p.S196S	NM_001130011	NP_001123483	Q9BY14	TX101_HUMAN	testis expressed 101 isoform 2	178						anchored to membrane|plasma membrane				ovary(1)	1		Prostate(69;0.0199)				GCATTGAGTCGTCTGTGGAGG	0.522			NA											27	75					0	0	0.099896	0	0
ATAD2B	54454	broad.mit.edu	37	2	24103532	24103532	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr2:24103532T>A	uc002rek.3	-	7	1172	c.878A>T	c.(877-879)GAT>GTT	p.D293V	ATAD2B_uc010yki.1_RNA|ATAD2B_uc010exx.1_Missense_Mutation_p.D307V	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	293							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGGTATCGATCCACTGTTTT	0.358			NA											7	12					0	0	0.248553	0	0
FSHR	2492	broad.mit.edu	37	2	49195904	49195904	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr2:49195904C>T	uc002rww.2	-	9	861	c.787G>A	c.(787-789)GCC>ACC	p.A263T	FSHR_uc002rwx.2_Intron|FSHR_uc010fbn.2_Missense_Mutation_p.A237T	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	263	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCCATGAGGGCGACAAGCTTT	0.498			NA							Gonadal_Dysgenesis_46_XX				15	41					0	0	0.11911	0	0
PROKR1	10887	broad.mit.edu	37	2	68882446	68882446	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr2:68882446G>A	uc010yqj.1	+	2	920	c.920G>A	c.(919-921)CGC>CAC	p.R307H	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	307	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1						ACCATCGTGCGCGACTTCTTC	0.577			NA											14	34					0	0	0.11911	0	0
EGR4	1961	broad.mit.edu	37	2	73518784	73518784	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr2:73518784C>T	uc010yrj.1	-	2	1646	c.1571G>A	c.(1570-1572)CGC>CAC	p.R524H	EGR4_uc010yrk.1_Missense_Mutation_p.R523H	NM_001965	NP_001956	Q05215	EGR4_HUMAN	early growth response 4	420						intracellular	nucleic acid binding|zinc ion binding				0						GTGGTCGCTGCGGCTGAAGTT	0.657			NA											11	43					0	0	0.080935	0	0
TTN	7273	broad.mit.edu	37	2	179437059	179437059	+	Silent	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr2:179437059G>A	uc010zfg.1	-	275	66320	c.66096C>T	c.(66094-66096)GGC>GGT	p.G22032G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.G15727G|TTN_uc010zfi.1_Silent_p.G15660G|TTN_uc010zfj.1_Silent_p.G15535G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22959							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGCCCAATGCCATATTCAT	0.448			NA											16	33					0	0	0.132662	0	0
COL6A3	1293	broad.mit.edu	37	2	238289959	238289959	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr2:238289959A>G	uc002vwl.2	-	5	1781	c.1496T>C	c.(1495-1497)TTC>TCC	p.F499S	COL6A3_uc002vwo.2_Missense_Mutation_p.F293S|COL6A3_uc010znj.1_Missense_Mutation_p.F92S|COL6A3_uc002vwq.2_Missense_Mutation_p.F293S|COL6A3_uc002vwr.2_Missense_Mutation_p.F92S|COL6A3_uc010znk.1_Missense_Mutation_p.F499S	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	499	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATGGGTATTGAAATAAAATTC	0.502			NA											39	118					0	0	0.268233	0	0
EYA2	2139	broad.mit.edu	37	20	45808545	45808545	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr20:45808545A>G	uc002xsm.2	+	13	1672	c.1298A>G	c.(1297-1299)AAC>AGC	p.N433S	EYA2_uc010ghp.2_Intron|EYA2_uc002xsn.2_Missense_Mutation_p.N438S|EYA2_uc002xso.2_Missense_Mutation_p.N433S|EYA2_uc002xsp.2_Missense_Mutation_p.N433S|EYA2_uc002xsq.2_Missense_Mutation_p.N403S	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	433					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				AAGGCACTAAACCTCATCAAC	0.567	Pancreas(120;56 1725 18501 25218 43520)		NA											6	14					0	0	0.248553	0	0
PCK1	5105	broad.mit.edu	37	20	56137755	56137755	+	Missense_Mutation	SNP	G	G	A	rs150560473		TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr20:56137755G>A	uc002xyn.3	+	4	573	c.410G>A	c.(409-411)CGC>CAC	p.R137H	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	137					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCTGTAGGTCGCACCATGTAC	0.562			NA											9	18					0	0	0.047766	0	0
CAMK1	8536	broad.mit.edu	37	3	9801424	9801424	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:9801424G>T	uc003bst.2	-	9	934	c.756C>A	c.(754-756)TTC>TTA	p.F252L	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA|CAMK1_uc003bss.2_Missense_Mutation_p.F26L|uc003bsv.1_5'Flank	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	252	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		AGTGCCGGATGAAATCTTTGG	0.522			NA											56	130					4.6707e-30	5.0232e-30	0.139131	1	0
SCN10A	6336	broad.mit.edu	37	3	38791573	38791573	+	Missense_Mutation	SNP	C	C	T	rs151303346	byFrequency	TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:38791573C>T	uc003ciq.2	-	12	1858	c.1858G>A	c.(1858-1860)GTC>ATC	p.V620I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	620					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCCTCAAGGACGGAGGTTATG	0.458			NA											6	16					0	0	0.248553	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266137	41266137	+	Missense_Mutation	SNP	C	C	T	rs121913409		TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:41266137C>T	uc010hia.1	+	4	290	c.134C>T	c.(133-135)TCT>TTT	p.S45F	CTNNB1_uc003ckp.2_Missense_Mutation_p.S45F|CTNNB1_uc003ckq.2_Missense_Mutation_p.S45F|CTNNB1_uc003ckr.2_Missense_Mutation_p.S45F|CTNNB1_uc011azf.1_Missense_Mutation_p.S38F|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	45			Missing (in colorectal cancer).|S -> P (in hepatocellular carcinoma).|S -> F (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S45F(396)|p.S45P(163)|p.S45del(79)|p.A5_A80del(63)|p.S45Y(21)|p.S45C(18)|p.S45A(10)|p.H24_S47del(9)|p.A5_Q143del(7)|p.A5_A80>D(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.V22_L139>V(2)|p.T3_A126del(2)|p.D32_S47del(2)|p.P44_S45del(2)|p.M5_N141>D(2)|p.?(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A5_Q72del(1)|p.A20_Q143del(1)|p.A5_Q143>E(1)|p.A13_R151del(1)|p.H36_E53>L(1)|p.A43_E54del(1)|p.S45_S47>C(1)|p.M14_S45del(1)|p.S45_G48del(1)|p.A5_G80>(1)|p.Q28_Q61del(1)|p.D6_K133del(1)|p.A43_E53del(1)|p.M8_G50del(1)|p.M1_A87del(1)|p.S45_L46del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.A5_D144>D(1)|p.P44_N51del(1)|p.P44_S45>AP(1)|p.V22_G80>NNNNN(1)|p.V22_A80del(1)|p.I35_K170del(1)|p.Y30_A97del(1)|p.T42_G48del(1)|p.S45_D58del(1)|p.V22_T102del(1)|p.A20_A80del(1)|p.V22_S71>A(1)|p.S45fs*2(1)|p.T40_L46del(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.W25_A80del(1)|p.A5_R90del(1)|p.H24_M131del(1)|p.S45E(1)|p.A20_R151del(1)|p.D17_A126del(1)|p.M8_A80del(1)|p.P44_S45insGATTTAP(1)|p.K19_Y142>V(1)|p.A5_E54del(1)|p.L7_I140del(1)|p.S45T(1)|p.A21_A80del(1)|p.E9_I140del(1)|p.S45S(1)|p.P16_K133del(1)|p.V22_Y64del(1)|p.G38_S45del(1)|p.E9_A80del(1)|p.D6_I140del(1)|p.S23_I140del(1)|p.A20_L148del(1)|p.Q28_I140del(1)|p.S45_E54del(1)|p.A20_Q72del(1)|p.D17_P128del(1)|p.A20_S111del(1)|p.E9_S47del(1)|p.Y30_A80del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	ACAGCTCCTTCTCTGAGTGGT	0.498	Colon(6;3 56 14213 18255)	S45F(HCC15_LUNG)|S45F(LS180_LARGE_INTESTINE)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				9	32					0	0	0.058154	0	0
SNRK	54861	broad.mit.edu	37	3	43381980	43381980	+	Silent	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:43381980C>T	uc003cms.3	+	5	1265	c.933C>T	c.(931-933)GAC>GAT	p.D311D	SNRK_uc003cmt.3_Silent_p.D311D|SNRK_uc010hik.2_Silent_p.D311D|SNRK_uc011azr.1_Silent_p.D105D	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	311	UBA.				myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		CGGATCGAGACGCCATTGTAG	0.488			NA											8	21					0	0	0.058154	0	0
BSN	8927	broad.mit.edu	37	3	49693126	49693126	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:49693126G>A	uc003cxe.3	+	5	6251	c.6137G>A	c.(6136-6138)CGT>CAT	p.R2046H		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2046					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		ACGGACCTGCGTCATCCTACA	0.587			NA											25	97					0	0	0.116897	0	0
BOC	91653	broad.mit.edu	37	3	112998136	112998136	+	Silent	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:112998136C>T	uc003dzx.2	+	12	2475	c.1854C>T	c.(1852-1854)TCC>TCT	p.S618S	BOC_uc003dzy.2_Silent_p.S618S|BOC_uc003dzz.2_Silent_p.S619S|BOC_uc003eab.2_Silent_p.S319S|BOC_uc003eac.2_5'Flank	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	618	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			CCACGGCCTCCGAGACCTCAG	0.572			NA											12	23					0	0	0.09319	0	0
ADCY5	111	broad.mit.edu	37	3	123021953	123021953	+	Silent	SNP	G	G	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:123021953G>A	uc003egh.1	-	14	2673	c.2673C>T	c.(2671-2673)GGC>GGT	p.G891G	ADCY5_uc003egg.1_Silent_p.G524G|ADCY5_uc003egi.1_Silent_p.G450G	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	891	Extracellular (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CCTGCTCATCGCCCAGGCTGT	0.652			NA											13	41					0	0	0.09319	0	0
VEPH1	79674	broad.mit.edu	37	3	157213089	157213089	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:157213089G>C	uc003fbj.1	-	2	367	c.50C>G	c.(49-51)GCT>GGT	p.A17G	VEPH1_uc003fbk.1_Missense_Mutation_p.A17G|VEPH1_uc010hvu.1_Missense_Mutation_p.A17G|VEPH1_uc003fbm.2_Missense_Mutation_p.A17G|VEPH1_uc003fbn.2_Missense_Mutation_p.A17G	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	17						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GAGGTCCCCAGCTCGTGAAAG	0.418			NA											34	80					0	0	0.225048	0	0
YEATS2	55689	broad.mit.edu	37	3	183515839	183515839	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:183515839G>C	uc003fly.2	+	22	3421	c.3226G>C	c.(3226-3228)GTG>CTG	p.V1076L		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1076					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGTGAATAAAGGTGAGTCCCT	0.587			NA											10	19					0	0	0.058154	0	0
NDST3	9348	broad.mit.edu	37	4	119059263	119059263	+	Missense_Mutation	SNP	G	G	A	rs150758016	byFrequency	TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr4:119059263G>A	uc003ibx.2	+	5	1682	c.1279G>A	c.(1279-1281)GTC>ATC	p.V427I	NDST3_uc011cgf.1_Missense_Mutation_p.V346I	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	427	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CCATTCGGGCGTCTACCCTGT	0.468			NA											19	55					0	0	0.219247	0	0
FGFR1	2260	broad.mit.edu	37	8	38314896	38314896	+	Silent	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr8:38314896C>T	uc003xlp.2	-	2	1011	c.69G>A	c.(67-69)CCG>CCA	p.P23P	FGFR1_uc011lbo.1_Silent_p.P23P|FGFR1_uc011lbp.1_Silent_p.P23P|FGFR1_uc011lbq.1_Silent_p.P23P|FGFR1_uc010lwk.2_5'UTR|FGFR1_uc011lbs.1_5'UTR|FGFR1_uc011lbt.1_Silent_p.P23P|FGFR1_uc011lbu.1_Silent_p.P56P|FGFR1_uc011lbv.1_Silent_p.P23P|FGFR1_uc011lbw.1_Silent_p.P23P|FGFR1_uc011lbx.1_Silent_p.P23P|FGFR1_uc003xlv.2_Silent_p.P23P|FGFR1_uc003xlu.2_Silent_p.P23P|FGFR1_uc003xlw.1_RNA	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	23	Extracellular (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	AGGTCGGGGACGGCCTAGCGG	0.612	Melanoma(146;1153 1840 21453 21841 43625)		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						15	21					0	0	0.132662	0	0
CHD7	55636	broad.mit.edu	37	8	61765656	61765656	+	Silent	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr8:61765656C>T	uc003xue.2	+	31	6849	c.6372C>T	c.(6370-6372)TTC>TTT	p.F2124F		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2124					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGTTATCCTTCTTGGATGCAC	0.498			NA											11	30					0	0	0.069234	0	0
VPS13B	157680	broad.mit.edu	37	8	100523686	100523686	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr8:100523686A>G	uc003yiv.2	+	29	4765	c.4654A>G	c.(4654-4656)AGT>GGT	p.S1552G	VPS13B_uc003yiw.2_Missense_Mutation_p.S1527G|VPS13B_uc003yix.1_Missense_Mutation_p.S1022G	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1552					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGTCAACACAAGTGTAATCAG	0.348	Colon(161;2205 2542 7338 31318)		NA											19	23					0	0	0.219247	0	0
ASTN2	23245	broad.mit.edu	37	9	119976967	119976967	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr9:119976967C>T	uc004bjs.1	-	3	786	c.685G>A	c.(685-687)GCC>ACC	p.A229T	ASTN2_uc004bjr.1_Missense_Mutation_p.A229T|ASTN2_uc004bjt.1_Missense_Mutation_p.A229T	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	229	Cytoplasmic (Potential).		A -> V (found in a clear cell renal carcinoma case; somatic mutation).			integral to membrane		p.A229V(1)		skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGTCGCTGGGCGTACAGCGCC	0.607			NA											13	20					0	0	0.09319	0	0
C9orf106	414318	broad.mit.edu	37	9	132084686	132084686	+	Silent	SNP	T	T	C			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr9:132084686T>C	uc004bxs.2	+	2	647	c.594T>C	c.(592-594)CAT>CAC	p.H198H		NM_001012715	NP_001012733	Q8NAJ2	CI106_HUMAN	hypothetical protein LOC414318	198											0		Ovarian(14;0.00556)|Medulloblastoma(224;0.235)				GGGGTAAACATGGTCCCAGGC	0.597			NA											12	37					0	0	0.080935	0	0
USP20	10868	broad.mit.edu	37	9	132637634	132637634	+	Silent	SNP	C	C	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr9:132637634C>T	uc004bys.2	+	20	2305	c.2094C>T	c.(2092-2094)TCC>TCT	p.S698S	USP20_uc004byr.2_Silent_p.S698S|USP20_uc004byt.1_Silent_p.S698S	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	698	DUSP 1.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				AGGTGGTGTCCCTGGCCGCCA	0.662			NA											5	11					0	0	0.217242	0	0
TUBB2C	10383	broad.mit.edu	37	9	140136447	140136447	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr9:140136447T>A	uc004cmh.1	+	3	353	c.251T>A	c.(250-252)ATC>AAC	p.I84N	TUBB2C_uc004cmg.1_5'UTR	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	84					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TTCGGGCAGATCTTCCGGCCG	0.701			NA											6	23					0	0	0.217242	0	0
NLRX1	79671	broad.mit.edu	37	11	119045824	119045825	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr11:119045824_119045825insT	uc001pvu.2	+	6	1727_1728	c.1512_1513insT	c.(1510-1515)CTCTACfs	p.L504fs	NLRX1_uc010rzc.1_Frame_Shift_Ins_p.L326fs|NLRX1_uc001pvv.2_Frame_Shift_Ins_p.L504fs|NLRX1_uc001pvw.2_Frame_Shift_Ins_p.L504fs|NLRX1_uc001pvx.2_Frame_Shift_Ins_p.L504fs	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	504_505	Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGGCTGCCCTCTACATTGTGCT	0.624			NA											36	41	---	---	---	---	NA	NA	NA	NA	NA
TSC2	7249	broad.mit.edu	37	16	2121863	2121865	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	AGG	AGG	-	-	AGG	AGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr16:2121863_2121865delAGG	uc002con.2	+	19	2131_2133	c.2025_2027delAGG	c.(2023-2028)GCAGGC>GCC	p.G676del	TSC2_uc010bsd.2_In_Frame_Del_p.G676del|TSC2_uc002coo.2_In_Frame_Del_p.G676del|TSC2_uc010uvv.1_In_Frame_Del_p.G639del|TSC2_uc010uvw.1_In_Frame_Del_p.G627del|TSC2_uc002cop.2_In_Frame_Del_p.G476del	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	676					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CGGCGCCTGCAGGCCCCGCCGTG	0.685			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				2	4	---	---	---	---	NA	NA	NA	NA	NA
TMEM101	84336	broad.mit.edu	37	17	42091891	42091891	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr17:42091891delG	uc002ieu.2	-	2	177	c.152delC	c.(151-153)CCAfs	p.P51fs	TMEM101_uc010wis.1_5'UTR	NM_032376	NP_115752	Q96IK0	TM101_HUMAN	transmembrane protein 101	51					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		Breast(137;0.0264)|Prostate(33;0.0861)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GTAAGGCACTGGGATGTCGGG	0.622			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
SETD2	29072	broad.mit.edu	37	3	47143009	47143010	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chr3:47143009_47143010insA	uc003cqs.2	-	8	5006_5007	c.4953_4954insT	c.(4951-4956)TTTACCfs	p.F1651fs	SETD2_uc003cqv.2_Frame_Shift_Ins_p.F1718fs	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1651_1652	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AGTTTGGTGGTAAAAAACCCAA	0.342			NA	N|F|S|Mis		clear cell renal carcinoma								40	145	---	---	---	---	NA	NA	NA	NA	NA
FAM58A	92002	broad.mit.edu	37	X	152858167	152858167	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4425-01A-01D-1753-08	TCGA-05-4425-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4a367804-9934-4241-90da-0ba0245564bd	9fdb4cff-c29d-4070-a847-7cb92547cd6e	g.chrX:152858167delG	uc010nug.2	-	3	371	c.268delC	c.(268-270)CTCfs	p.L90fs				Q8N1B3	FA58A_HUMAN	RecName: Full=Cyclin-related protein FAM58B;	152					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGTTCTGGAGGGAAACCAGG	0.577			NA											10	14	---	---	---	---	NA	NA	NA	NA	NA