Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NOC2L	26155	broad.mit.edu	37	1	880905	880905	+	Silent	SNP	C	C	A	rs149040522		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:880905C>A	uc001abz.3	-	17	2105	c.2046G>T	c.(2044-2046)TCG>TCT	p.S682S	NOC2L_uc001aby.3_Silent_p.S479S|NOC2L_uc009vjq.2_Silent_p.S682S	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	682	Asp/Glu-rich (acidic).					nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CACCTCTCTCCGAGAATCCCT	0.592			NA											30	36					2.65835e-16	4.39616e-16	0.007291	1	0
NOC2L	26155	broad.mit.edu	37	1	889421	889421	+	Missense_Mutation	SNP	C	C	A	rs3828050		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:889421C>A	uc001abz.3	-	7	799	c.740G>T	c.(739-741)CGT>CTT	p.R247L	NOC2L_uc001aby.3_Missense_Mutation_p.R44L|NOC2L_uc009vjq.2_Missense_Mutation_p.R247L	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	247						nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GATGTCCACACGAAGCTTCCC	0.647			NA											25	51					7.33532e-06	8.68679e-06	0.003954	1	0
Unknown	0	broad.mit.edu	37	1	1854576	1854576	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:1854576G>A	uc001aik.2	-	9	1379	c.529C>T	c.(529-531)CGG>TGG	p.R177W	uc001ail.2_Missense_Mutation_p.R177W					RecName: Full=Uncharacterized protein C1orf222;												NA						GGGCCTGGCCGGGAGCTGGCT	0.642			NA											5	16					0	0	0.001168	0	0
MEGF6	1953	broad.mit.edu	37	1	3440803	3440803	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:3440803G>C	uc001akl.2	-	5	716	c.489C>G	c.(487-489)GAC>GAG	p.D163E	MEGF6_uc001akk.2_Missense_Mutation_p.D58E	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	163	EGF-like 2; calcium-binding (Potential).					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TTCGGCATTCGTCCACATCTG	0.652	Ovarian(73;978 3658)		NA											9	26					0	0	0.001855	0	0
CHD5	26038	broad.mit.edu	37	1	6184629	6184629	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:6184629G>C	uc001amb.1	-	30	4587	c.4487C>G	c.(4486-4488)TCC>TGC	p.S1496C	CHD5_uc001alz.1_Missense_Mutation_p.S353C|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_Intron	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1496					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTGCTGCCTGGAGAGGCCCTC	0.642			NA											3	20					0	0	0.004672	0	0
KIF1B	23095	broad.mit.edu	37	1	10431226	10431226	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:10431226G>T	uc001aqx.3	+	45	5054	c.4852G>T	c.(4852-4854)GAT>TAT	p.D1618Y	KIF1B_uc001aqw.3_Missense_Mutation_p.D1572Y|KIF1B_uc001aqy.2_Missense_Mutation_p.D1592Y|KIF1B_uc001aqz.2_Missense_Mutation_p.D1618Y|KIF1B_uc001ara.2_Missense_Mutation_p.D1578Y|KIF1B_uc001arb.2_Missense_Mutation_p.D1604Y	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1618					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AATTGGACGGGATCCCTCTGA	0.483			NA											23	36					1.1804e-14	1.89085e-14	0.003954	1	0
MTOR	2475	broad.mit.edu	37	1	11272478	11272478	+	Missense_Mutation	SNP	T	T	C	rs151082401		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:11272478T>C	uc001asd.2	-	23	3573	c.3452A>G	c.(3451-3453)TAT>TGT	p.Y1151C		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1151	HEAT 7.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CCGGGAGGCATAGTCAGTGAA	0.507			NA											10	44					0	0	0.006214	0	0
PTCHD2	57540	broad.mit.edu	37	1	11591678	11591678	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:11591678G>T	uc001ash.3	+	17	3424	c.3286G>T	c.(3286-3288)GAG>TAG	p.E1096*		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1096	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GGAGCTGCCCGAGCCCAACCT	0.662			NA											14	28					1.52009e-12	2.30153e-12	0.003163	1	0
PTCHD2	57540	broad.mit.edu	37	1	11596643	11596643	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:11596643T>C	uc001ash.3	+	21	4217	c.4079T>C	c.(4078-4080)CTG>CCG	p.L1360P		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1360	Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CTCAAGGCCCTGGGTGCCGTG	0.672			NA											5	14					0	0	0.001984	0	0
PTCHD2	57540	broad.mit.edu	37	1	11596647	11596647	+	Silent	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:11596647T>G	uc001ash.3	+	21	4221	c.4083T>G	c.(4081-4083)GGT>GGG	p.G1361G		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1361	Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGGCCCTGGGTGCCGTGCTGC	0.672			NA											4	11					0	0	0.001168	0	0
VPS13D	55187	broad.mit.edu	37	1	12328835	12328835	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:12328835G>C	uc001atv.2	+	16	2015	c.1874G>C	c.(1873-1875)CGG>CCG	p.R625P	VPS13D_uc001atw.2_Missense_Mutation_p.R625P	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	625					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTTGAGAGGCGGCTCAATGTC	0.463			NA											71	151					0	0	0.00361	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854318	12854318	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:12854318G>T	uc001auj.1	+	3	645	c.542G>T	c.(541-543)TGC>TTC	p.C181F		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	181											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTACACCTGTGCTGTAGTAAG	0.403			NA											9	651					5.04308e-16	8.29956e-16	0.00623	1	0
LOC649330	649330	broad.mit.edu	37	1	12907903	12907903	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:12907903T>C	uc009vno.2	-	1	335	c.240A>G	c.(238-240)GTA>GTG	p.V80V	HNRNPCL1_uc010obf.1_Silent_p.V80V	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	80							nucleic acid binding|nucleotide binding				0						GGTTAATATCTACAACCTGGC	0.488			NA											12	185					0	0	0.000978	0	0
PDPN	10630	broad.mit.edu	37	1	13936946	13936946	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:13936946C>G	uc001avd.2	+	3	543	c.494C>G	c.(493-495)ACA>AGA	p.T165R	PDPN_uc001avc.2_Missense_Mutation_p.T165R|PDPN_uc009vob.2_Missense_Mutation_p.T47R|PDPN_uc009voc.2_Missense_Mutation_p.T47R|PDPN_uc001ave.2_Missense_Mutation_p.T47R|PDPN_uc001avf.2_Missense_Mutation_p.T47R	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	89	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		TCAGAAAGCACAGTCCACGCG	0.502			NA											9	49					0	0	0.004482	0	0
TMEM51	55092	broad.mit.edu	37	1	15541749	15541749	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:15541749G>C	uc001avw.3	+	3	685	c.166G>C	c.(166-168)GGC>CGC	p.G56R	TMEM51_uc010obk.1_Missense_Mutation_p.G56R|TMEM51_uc001avz.2_Missense_Mutation_p.G56R|TMEM51_uc001avy.2_Missense_Mutation_p.G56R|TMEM51_uc001avx.2_Missense_Mutation_p.G56R	NM_001136216	NP_001129688	Q9NW97	TMM51_HUMAN	transmembrane protein 51	56						integral to membrane					0		Renal(390;0.00145)|Breast(348;0.00186)|Colorectal(325;0.00215)|all_lung(284;0.00459)|Lung NSC(340;0.0104)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;2.07e-06)|COAD - Colon adenocarcinoma(227;7.14e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000175)|KIRC - Kidney renal clear cell carcinoma(229;0.00141)|STAD - Stomach adenocarcinoma(313;0.00644)|READ - Rectum adenocarcinoma(331;0.0751)		GGTGGGTGGCGGCATCCTCAA	0.607			NA											48	101					0	0	0.00361	0	0
EPHA2	1969	broad.mit.edu	37	1	16464386	16464386	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:16464386C>A	uc001aya.1	-	5	1411	c.1274G>T	c.(1273-1275)CGC>CTC	p.R425L	EPHA2_uc010oca.1_Missense_Mutation_p.R425L	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	425	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACGGAAGCTGCGGCTGGTTAC	0.632			NA											15	38					1.15919e-05	1.36171e-05	0.008871	1	0
PLA2G2A	5320	broad.mit.edu	37	1	20302256	20302256	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:20302256A>T	uc001bcu.2	-	5	591	c.373T>A	c.(373-375)TAC>AAC	p.Y125N	PLA2G2A_uc001bcv.2_Missense_Mutation_p.Y125N|PLA2G2A_uc010oda.1_Missense_Mutation_p.Y125N|PLA2G2A_uc010odb.1_Missense_Mutation_p.Y125N	NM_001161729	NP_001155201	P14555	PA2GA_HUMAN	phospholipase A2, group IIA precursor	125					defense response to Gram-positive bacterium|lipid catabolic process|low-density lipoprotein particle remodeling|phosphatidic acid metabolic process|positive regulation of inflammatory response|positive regulation of macrophage derived foam cell differentiation	endoplasmic reticulum|extracellular space|membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|phospholipid binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000138)|Kidney(64;0.000171)|GBM - Glioblastoma multiforme(114;0.00032)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TTTTTATTGTAGGTCGTCTTG	0.458			NA											11	49					0	0	0.001368	0	0
ALPL	249	broad.mit.edu	37	1	21902372	21902372	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:21902372G>A	uc001bet.2	+	10	1401	c.1144G>A	c.(1144-1146)GTC>ATC	p.V382I	ALPL_uc010odn.1_Missense_Mutation_p.V330I|ALPL_uc010odo.1_Missense_Mutation_p.V327I|ALPL_uc010odp.1_Missense_Mutation_p.V305I|ALPL_uc001beu.3_Missense_Mutation_p.V382I	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	382			V -> I (in HOPS).		response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	CCATTCCCACGTCTTCACATT	0.607			NA											8	139					0	0	0.008291	0	0
CELA3A	10136	broad.mit.edu	37	1	22333450	22333450	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:22333450G>A	uc001bfl.2	+	5	461	c.442G>A	c.(442-444)GGT>AGT	p.G148S		NM_005747	NP_005738	P09093	CEL3A_HUMAN	elastase 3A, pancreatic preproprotein	148	Peptidase S1.				cholesterol metabolic process|digestion|proteolysis		serine-type endopeptidase activity			haematopoietic_and_lymphoid_tissue(1)	1						CCCTCCCGCTGGTGACATCCT	0.602			NA											37	69					0	0	0.005524	0	0
SLC30A2	7780	broad.mit.edu	37	1	26371649	26371649	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:26371649C>A	uc001blh.1	-	2	327	c.110G>T	c.(109-111)GGC>GTC	p.G37V	SLC30A2_uc001blg.1_Missense_Mutation_p.G37V	NM_032513	NP_115902	Q9BRI3	ZNT2_HUMAN	solute carrier family 30, member 2 isoform 2	37	Cytoplasmic (Potential).				positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGTCCAGGCCAGGTCGGGG	0.612			NA											22	68					1.10513e-12	1.68826e-12	0.002299	1	0
RPS6KA1	6195	broad.mit.edu	37	1	26887237	26887237	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:26887237G>T	uc001bmr.1	+	15	1399	c.1236G>T	c.(1234-1236)CTG>CTT	p.L412L	RPS6KA1_uc010ofe.1_Silent_p.L320L|RPS6KA1_uc010off.1_Silent_p.L396L|RPS6KA1_uc001bms.1_Silent_p.L421L|RPS6KA1_uc009vsl.1_Silent_p.L255L	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	412					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		GGAAGAACCTGGTTTTTAGTG	0.517			NA											28	43					5.77227e-19	9.91472e-19	0.008361	1	0
ARID1A	8289	broad.mit.edu	37	1	27100358	27100358	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:27100358A>T	uc001bmv.1	+	17	4443	c.4070A>T	c.(4069-4071)CAG>CTG	p.Q1357L	ARID1A_uc001bmt.1_Missense_Mutation_p.Q1356L|ARID1A_uc001bmu.1_Missense_Mutation_p.Q1357L|ARID1A_uc001bmw.1_Missense_Mutation_p.Q974L|ARID1A_uc001bmx.1_Missense_Mutation_p.Q203L|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1357	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TTCCCCAGCCAGCAGACTACA	0.502			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								69	151					0	0	0.00361	0	0
MATN1	4146	broad.mit.edu	37	1	31194360	31194360	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:31194360G>T	uc001brz.2	-	2	367	c.333C>A	c.(331-333)ATC>ATA	p.I111I	uc001bsb.1_RNA|MATN1_uc001bsa.1_5'Flank	NM_002379	NP_002370	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein precursor	111	VWFA 1.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)	1		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGCGGCTGGATACGGCGCA	0.637			NA											25	85					2.50493e-22	4.45224e-22	0.004656	1	0
CLSPN	63967	broad.mit.edu	37	1	36217085	36217085	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:36217085T>A	uc001bzi.2	-	10	1874	c.1794A>T	c.(1792-1794)AAA>AAT	p.K598N	CLSPN_uc009vux.2_Missense_Mutation_p.K534N	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	598	Potential.				activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCAGTTTAGCTTTTAACACCT	0.378			NA											12	32					0	0	0.001855	0	0
KCNQ4	9132	broad.mit.edu	37	1	41304035	41304035	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:41304035G>T	uc001cgh.1	+	14	2010	c.1928G>T	c.(1927-1929)TGC>TTC	p.C643F	KCNQ4_uc001cgi.1_Missense_Mutation_p.C589F	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	643	|Cytoplasmic.|A-domain (Tetramerization).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TATTCGCGCTGCCTGCGCTCT	0.682			NA											27	77					4.87955e-14	7.70774e-14	0.005443	1	0
CCDC30	728621	broad.mit.edu	37	1	43108212	43108212	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:43108212G>T	uc009vwk.1	+	12	1817	c.1707G>T	c.(1705-1707)CAG>CAT	p.Q569H	CCDC30_uc001chm.2_Missense_Mutation_p.Q267H|CCDC30_uc001chn.2_Missense_Mutation_p.Q358H	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	569	Potential.										0						GGAAACTTCAGGAGCAAGTCA	0.458			NA											52	132					9.79885e-19	1.68027e-18	0.00361	1	0
PDE4B	5142	broad.mit.edu	37	1	66833714	66833714	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:66833714T>A	uc001dcn.2	+	15	1819	c.1628T>A	c.(1627-1629)GTT>GAT	p.V543D	PDE4B_uc009war.2_Missense_Mutation_p.V451D|PDE4B_uc001dco.2_Missense_Mutation_p.V543D|PDE4B_uc001dcp.2_Missense_Mutation_p.V528D|PDE4B_uc001dcq.2_Missense_Mutation_p.V371D|PDE4B_uc009was.2_Missense_Mutation_p.V310D	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	543					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AGTTCAGGCGTTCTTCTCCTA	0.383			NA											6	41					0	0	0.001984	0	0
LRRC7	57554	broad.mit.edu	37	1	70505179	70505179	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:70505179G>A	uc001dep.2	+	19	3588	c.3558G>A	c.(3556-3558)GCG>GCA	p.A1186A	LRRC7_uc009wbg.2_Silent_p.A470A|LRRC7_uc001deq.2_Silent_p.A427A	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1186						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AAGCTCAGGCGGGAAGTTTTC	0.488			NA											6	26					0	0	0.001168	0	0
LRRC7	57554	broad.mit.edu	37	1	70505385	70505385	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:70505385C>A	uc001dep.2	+	19	3794	c.3764C>A	c.(3763-3765)ACT>AAT	p.T1255N	LRRC7_uc009wbg.2_Missense_Mutation_p.T539N|LRRC7_uc001deq.2_Missense_Mutation_p.T496N	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1255						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ACGAGGCCTACTCCTGTGAAG	0.448			NA											14	77					0.000151284	0.000169346	0.001855	1	0
GBP6	163351	broad.mit.edu	37	1	89847391	89847391	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:89847391A>T	uc001dnf.2	+	7	1284	c.1010A>T	c.(1009-1011)CAG>CTG	p.Q337L	GBP6_uc010ost.1_Missense_Mutation_p.Q207L	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	337							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		TACAGCCAGCAGATGGCCCAG	0.587			NA											4	36					0	0	0.001984	0	0
LPPR5	163404	broad.mit.edu	37	1	99418782	99418782	+	Nonsense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:99418782A>T	uc001dsb.2	-	3	687	c.465T>A	c.(463-465)TGT>TGA	p.C155*	LPPR5_uc001dsc.2_Nonsense_Mutation_p.C155*	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	155						integral to membrane	hydrolase activity				0						AATTGGGCTTACACAGGGCAA	0.458			NA											20	54					0	0	0.00333	0	0
LPPR4	9890	broad.mit.edu	37	1	99772039	99772039	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:99772039C>A	uc001dse.2	+	7	1871	c.1765C>A	c.(1765-1767)CTC>ATC	p.L589I	LPPR4_uc010oue.1_Missense_Mutation_p.L531I	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	589							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GCAGGGTGTCCTCCAAAGCAG	0.532			NA											11	19					6.40141e-05	7.26916e-05	0.000978	1	0
SASS6	163786	broad.mit.edu	37	1	100588014	100588014	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:100588014A>C	uc001dsu.2	-	4	374	c.233T>G	c.(232-234)GTA>GGA	p.V78G	SASS6_uc009wdz.2_5'UTR	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	78	PISA.				centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		TAAGAAGTCTACCAGAAGACC	0.308			NA											8	75					0	0	0.004482	0	0
COL11A1	1301	broad.mit.edu	37	1	103343713	103343713	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:103343713T>A	uc001dul.2	-	67	5601	c.5283A>T	c.(5281-5283)AAA>AAT	p.K1761N	COL11A1_uc001duk.2_Missense_Mutation_p.K957N|COL11A1_uc001dum.2_Missense_Mutation_p.K1773N|COL11A1_uc001dun.2_Missense_Mutation_p.K1722N|COL11A1_uc009weh.2_Missense_Mutation_p.K1645N	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1761	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTTCATAGCCTTTTCTGGACT	0.303			NA											4	18					0	0	0.009096	0	0
COL11A1	1301	broad.mit.edu	37	1	103544219	103544219	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:103544219G>T	uc001dul.2	-	3	801	c.483C>A	c.(481-483)GAC>GAA	p.D161E	COL11A1_uc001dum.2_Missense_Mutation_p.D161E|COL11A1_uc001dun.2_Missense_Mutation_p.D161E|COL11A1_uc009weh.2_Missense_Mutation_p.D161E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	161	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTACTTCCCGTCAGCGATGT	0.308			NA											7	39					2.0095e-06	2.43619e-06	0.001984	1	0
NTNG1	22854	broad.mit.edu	37	1	107973450	107973450	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:107973450A>T	uc001dvh.3	+	6	1884	c.1166A>T	c.(1165-1167)CAC>CTC	p.H389L	NTNG1_uc001dvf.3_Intron|NTNG1_uc010out.1_Intron|NTNG1_uc001dvc.3_Intron|NTNG1_uc001dvi.2_Intron|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_Intron|NTNG1_uc001dvg.2_Intron|NTNG1_uc009wem.2_Intron	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	389	Laminin EGF-like 2.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		AGCTGTAAACACAACACTAGA	0.453			NA											3	27					0	0	0.009096	0	0
VAV3	10451	broad.mit.edu	37	1	108303503	108303503	+	Splice_Site	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:108303503T>A	uc001dvk.1	-	10	976	c.922_splice	c.e10-1	p.E308_splice	VAV3_uc010ouw.1_Splice_Site_p.E308_splice|VAV3_uc001dvl.1_Splice_Site_p.E132_splice|VAV3_uc010oux.1_Splice_Site_p.E308_splice	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GGAACATTCCTAATGAAATGT	0.363			NA											5	19					0	0	0.000602	0	0
SLC25A24	29957	broad.mit.edu	37	1	108681711	108681711	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:108681711C>T	uc001dvn.3	-	9	1432	c.1218G>A	c.(1216-1218)TTG>TTA	p.L406L	SLC25A24_uc001dvm.2_Silent_p.L387L	NM_013386	NP_037518	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 member 24 isoform 1	406	Solcar 3.|Helical; Name=5; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)	1		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		TCACCAAAGCCAATGGGTAGC	0.473			NA											21	37					0	0	0.010504	0	0
GNAI3	2773	broad.mit.edu	37	1	110134684	110134684	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:110134684G>T	uc001dxz.2	+	8	1051	c.894G>T	c.(892-894)GAG>GAT	p.E298D		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	298					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		CATATGAAGAGGCAGCTGCCT	0.413			NA											11	44					9.70103e-10	1.33259e-09	0.008291	1	0
GNAI3	2773	broad.mit.edu	37	1	110134687	110134687	+	Silent	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:110134687A>T	uc001dxz.2	+	8	1054	c.897A>T	c.(895-897)GCA>GCT	p.A299A		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	299					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		ATGAAGAGGCAGCTGCCTATA	0.418			NA											11	44					0	0	0.008291	0	0
IGSF3	3321	broad.mit.edu	37	1	117122426	117122426	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:117122426A>G	uc001egr.1	-	10	3627	c.2922T>C	c.(2920-2922)TGT>TGC	p.C974C	IGSF3_uc001egq.1_Silent_p.C994C	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	974	Ig-like C2-type 8.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		ACACGATGCTACAGTCCAGCT	0.602			NA											12	24					0	0	0.001368	0	0
NBPF9	400818	broad.mit.edu	37	1	144619896	144619896	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:144619896G>A	uc009wig.1	+	8	656	c.580G>A	c.(580-582)GCT>ACT	p.A194T	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.A194T|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.A125T|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.A125T|NBPF9_uc010oyg.1_Missense_Mutation_p.A159T|NBPF9_uc009wii.1_5'UTR	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	194	NBPF 1.					cytoplasm					0						GGTGCAGAAGGCTGAAGTGAG	0.527			NA											3	22					0	0	0.004672	0	0
S100A5	6276	broad.mit.edu	37	1	153512581	153512581	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:153512581C>G	uc001fbx.2	-	3	369	c.141G>C	c.(139-141)CTG>CTC	p.L47L		NM_002962	NP_002953	P33763	S10A5_HUMAN	S100 calcium binding protein A5	29	1; low affinity (Potential).|EF-hand 1.					nucleus	calcium ion binding|copper ion binding|protein homodimerization activity|zinc ion binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCTTCCTACTCAGGGTCAGTT	0.522			NA											17	116					0	0	0.006122	0	0
FLAD1	80308	broad.mit.edu	37	1	154962050	154962050	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:154962050A>G	uc001fgf.1	+	3	1486	c.1132A>G	c.(1132-1134)AAA>GAA	p.K378E	FLAD1_uc001fgd.1_Missense_Mutation_p.K378E|FLAD1_uc001fge.1_Missense_Mutation_p.K281E|FLAD1_uc001fgg.1_Missense_Mutation_p.K281E|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	378					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTCTTTGGGGAAAAAGGTGGC	0.488			NA											5	102					0	0	0.001168	0	0
INSRR	3645	broad.mit.edu	37	1	156812857	156812857	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:156812857C>T	uc010pht.1	-	17	3319	c.3065G>A	c.(3064-3066)CGG>CAG	p.R1022Q	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	1022	Cytoplasmic (Potential).|Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AATGCATTCCCGTGGGCTGGC	0.537			NA											31	38					0	0	0.002445	0	0
FCER1A	2205	broad.mit.edu	37	1	159277583	159277583	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:159277583T>C	uc001ftq.2	+	6	734	c.635T>C	c.(634-636)GTG>GCG	p.V212A		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	212	Helical; (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CCATTGTTGGTGGTGATTCTG	0.408			NA											22	104					0	0	0.005443	0	0
LRRC52	440699	broad.mit.edu	37	1	165532835	165532835	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:165532835A>T	uc001gde.2	+	2	772	c.716A>T	c.(715-717)CAC>CTC	p.H239L	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	239	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					TGCATCACGCACCTGGACCAC	0.572			NA											12	23					0	0	0.001368	0	0
FMO4	2329	broad.mit.edu	37	1	171306562	171306562	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:171306562A>G	uc001gho.2	+	9	1465	c.1248A>G	c.(1246-1248)AAA>AAG	p.K416K	TOP1P1_uc010pmf.1_5'Flank	NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	416					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGCTCATTAAAAGGTATGAAA	0.343	Pancreas(24;816 862 7754 7993 32832)		NA											20	44					0	0	0.008871	0	0
GPR52	9293	broad.mit.edu	37	1	174417343	174417343	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:174417343G>T	uc001gka.1	+	1	132	c.94G>T	c.(94-96)GGC>TGC	p.G32C	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	32	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1						ACTTGGATTTGGCCACTACAG	0.473	Ovarian(92;924 1390 1930 16467 40583)		NA											10	52					2.17888e-05	2.54784e-05	0.006214	1	0
RFWD2	64326	broad.mit.edu	37	1	175956124	175956124	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:175956124T>A	uc001gku.1	-	18	2344	c.2088A>T	c.(2086-2088)ACA>ACT	p.T696T	RFWD2_uc001gkv.1_Silent_p.T672T|RFWD2_uc001gkw.1_Silent_p.T456T|RFWD2_uc009wwv.2_Silent_p.T495T|RFWD2_uc001gkt.1_Silent_p.T535T	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	696	WD 7.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						CAAATTCATTTGTATCATCTT	0.363	Ovarian(134;1413 1765 5706 35534 51541)		NA											36	65					0	0	0.00874	0	0
FAM5B	57795	broad.mit.edu	37	1	177250308	177250308	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:177250308C>A	uc001glf.2	+	8	2308	c.1996C>A	c.(1996-1998)CTG>ATG	p.L666M	FAM5B_uc001glg.2_Missense_Mutation_p.L561M	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	666						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CTATGAGCCCCTGGAGATGAC	0.468			NA											12	78					3.07112e-06	3.68823e-06	0.000978	1	0
KIAA1614	57710	broad.mit.edu	37	1	180905361	180905361	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:180905361C>T	uc001gok.2	+	5	2383	c.2316C>T	c.(2314-2316)TCC>TCT	p.S772S	KIAA1614_uc001gol.1_Silent_p.S393S|KIAA1614_uc001gom.1_Intron	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	772										ovary(3)|skin(1)	4						GCCACGAGTCCCTGGAAATTG	0.612			NA											14	26					0	0	0.003163	0	0
RNF2	6045	broad.mit.edu	37	1	185060780	185060780	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:185060780A>T	uc001grc.1	+	3	390	c.157A>T	c.(157-159)ATT>TTT	p.I53F	RNF2_uc001grd.1_Missense_Mutation_p.I53F|RNF2_uc001gre.1_5'Flank	NM_007212	NP_009143	Q99496	RING2_HUMAN	ring finger protein 2	53	Interaction with HIP2.|RING-type.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(1)	1		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		AATGTGCCCAATTTGTTTGGA	0.383			NA											68	118					0	0	0.00361	0	0
FAM5C	339479	broad.mit.edu	37	1	190067568	190067568	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:190067568G>T	uc001gse.1	-	8	2113	c.1881C>A	c.(1879-1881)ATC>ATA	p.I627I	FAM5C_uc010pot.1_Silent_p.I525I	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	627						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TTCTCAGGTAGATGTGTACTG	0.458			NA											102	170					1.32035e-51	2.53646e-51	0.00361	1	0
CFH	3075	broad.mit.edu	37	1	196706738	196706738	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:196706738A>C	uc001gtj.3	+	17	2970	c.2730A>C	c.(2728-2730)GAA>GAC	p.E910D		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	910	Sushi 15.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TATCTGAAGAAAATGAAACAA	0.368			NA											8	37					0	0	0.004482	0	0
CFHR1	3078	broad.mit.edu	37	1	196796100	196796100	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:196796100G>C	uc001gtn.2	+	3	509	c.395G>C	c.(394-396)CGG>CCG	p.R132P	CFHR1_uc001gtm.2_Intron	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	132	Sushi 2.				complement activation	extracellular space					0						TGTGTAGAACGGGGCTGGTCC	0.393			NA											28	58					0	0	0.009535	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204198174	204198174	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:204198174C>A	uc001hau.2	-	19	2959	c.2642G>T	c.(2641-2643)CGG>CTG	p.R881L		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	881										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			CTCCTCTGCCCGCAGGGCTGC	0.617			NA											7	44					5.18039e-06	6.17778e-06	0.00308	1	0
PM20D1	148811	broad.mit.edu	37	1	205809437	205809437	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:205809437G>A	uc001hdj.2	-	10	1104	c.1059C>T	c.(1057-1059)CCC>CCT	p.P353P	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	353						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GGGCCACTGGGGGGATGACAT	0.498			NA											13	23					0	0	0.00245	0	0
IKBKE	9641	broad.mit.edu	37	1	206653244	206653244	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:206653244A>G	uc001hdz.1	+	11	1583	c.1215A>G	c.(1213-1215)AAA>AAG	p.K405K	IKBKE_uc009xbv.1_Silent_p.K405K|IKBKE_uc001hea.1_Silent_p.K320K	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	405					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					TCGTCCCCAAAGTGGACCTGC	0.602			NA									OREG0014170	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	24					0	0	0.009096	0	0
IRF6	3664	broad.mit.edu	37	1	209974728	209974728	+	Nonsense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:209974728T>A	uc001hhq.1	-	3	294	c.31A>T	c.(31-33)AAG>TAG	p.K11*	IRF6_uc010psm.1_Intron|IRF6_uc009xct.1_Nonsense_Mutation_p.K11*	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	11	IRF tryptophan pentad repeat.				cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		AGCCAGGGCTTTAGCCGGACT	0.597			NA								HNSCC(57;0.16)			41	64					0	0	0.002522	0	0
USH2A	7399	broad.mit.edu	37	1	216062061	216062061	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:216062061A>T	uc001hku.1	-	41	8317	c.7930T>A	c.(7930-7932)TGG>AGG	p.W2644R		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2644	Extracellular (Potential).|Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGGGGTTGCCAAGATATAATC	0.507			NA								HNSCC(13;0.011)			10	50					0	0	0.000978	0	0
USH2A	7399	broad.mit.edu	37	1	216219923	216219923	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:216219923C>A	uc001hku.1	-	32	6562	c.6175G>T	c.(6175-6177)GTT>TTT	p.V2059F		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2059	Extracellular (Potential).|Fibronectin type-III 7.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGTGGCTGAACCTCTTGTGGG	0.378			NA								HNSCC(13;0.011)			11	48					1.5842e-08	2.06776e-08	0.001855	1	0
ITPKB	3707	broad.mit.edu	37	1	226923458	226923458	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:226923458C>G	uc010pvo.1	-	2	2042	c.1702G>C	c.(1702-1704)GCT>CCT	p.A568P	ITPKB_uc001hqh.2_Missense_Mutation_p.A568P	NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	568							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				ATGATGACAGCAGGTATGTTG	0.617	Colon(84;110 1851 5306 33547)		NA											8	18					0	0	0.00308	0	0
TRIM17	51127	broad.mit.edu	37	1	228596162	228596162	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:228596162G>C	uc001hsu.2	-	7	1559	c.1174C>G	c.(1174-1176)CAG>GAG	p.Q392E	TRIM11_uc001hss.2_5'Flank|TRIM11_uc010pvx.1_5'Flank|TRIM11_uc001hst.1_5'Flank|TRIM17_uc001hsv.2_Missense_Mutation_p.Q392E|TRIM17_uc001hsw.2_Missense_Mutation_p.Q365E	NM_016102	NP_057186	Q9Y577	TRI17_HUMAN	tripartite motif-containing 17 isoform 1	392	B30.2/SPRY.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Prostate(94;0.0724)				TTGGACAGCTGCACCACCCAG	0.612			NA											12	42					0	0	0.001855	0	0
KIAA1383	54627	broad.mit.edu	37	1	232943500	232943500	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:232943500G>T	uc001hvh.2	+	1	2863	c.2731G>T	c.(2731-2733)GGG>TGG	p.G911W		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	769	Ser-rich.									ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				TTTTTCAGCCGGGTCACCTGT	0.378			NA											11	42					1.08611e-07	1.37377e-07	0.000978	1	0
PCNXL2	80003	broad.mit.edu	37	1	233394783	233394783	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:233394783C>A	uc001hvl.2	-	5	1060	c.825G>T	c.(823-825)CCG>CCT	p.P275P	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	275						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CACTCCCCCACGGCTGGAAAG	0.522			NA											28	19					1.42536e-11	2.08102e-11	0.004656	1	0
RYR2	6262	broad.mit.edu	37	1	237881823	237881823	+	Splice_Site	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:237881823T>A	uc001hyl.1	+	73	10674	c.10554_splice	c.e73+2	p.K3518_splice	RYR2_uc010pxz.1_Splice_Site_p.K473_splice	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAAGGCAAGGTAAGCCAAATT	0.289			NA											3	20					0	0	0.009096	0	0
RYR2	6262	broad.mit.edu	37	1	237936818	237936818	+	Splice_Site	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:237936818A>T	uc001hyl.1	+	87	11767	c.11647_splice	c.e87-2	p.E3883_splice	RYR2_uc010pya.1_Splice_Site_p.E298_splice	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTATTTCCCAGGAATCAATT	0.323			NA											11	18					0	0	0.000978	0	0
KIF26B	55083	broad.mit.edu	37	1	245582977	245582977	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:245582977G>A	uc001ibf.1	+	4	1536	c.1096G>A	c.(1096-1098)GCC>ACC	p.A366T	KIF26B_uc010pyq.1_Missense_Mutation_p.A366T	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	366					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAGTGTCCCAGCCTCGCAGGG	0.582			NA											14	65					0	0	0.00245	0	0
KIF26B	55083	broad.mit.edu	37	1	245848767	245848767	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:245848767A>T	uc001ibf.1	+	12	2922	c.2482A>T	c.(2482-2484)ACC>TCC	p.T828S	KIF26B_uc001ibg.1_Missense_Mutation_p.T446S|KIF26B_uc001ibh.1_Missense_Mutation_p.T70S	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	828					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GCGCAGGCCCACCCAGCTGAG	0.642			NA											10	15					0	0	0.008291	0	0
ZNF695	57116	broad.mit.edu	37	1	247150365	247150365	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:247150365T>A	uc009xgu.2	-	4	1597	c.1452A>T	c.(1450-1452)ACA>ACT	p.T484T	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	484	C2H2-type 12.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGGTATGAATTGTCTTATGTT	0.398			NA											19	30					0	0	0.007413	0	0
NLRP3	114548	broad.mit.edu	37	1	247588321	247588321	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:247588321C>A	uc001icr.2	+	5	1714	c.1576C>A	c.(1576-1578)CAG>AAG	p.Q526K	NLRP3_uc001ics.2_Missense_Mutation_p.Q526K|NLRP3_uc001icu.2_Missense_Mutation_p.Q526K|NLRP3_uc001icw.2_Missense_Mutation_p.Q526K|NLRP3_uc001icv.2_Missense_Mutation_p.Q526K|NLRP3_uc010pyw.1_Missense_Mutation_p.Q524K|NLRP3_uc001ict.1_Missense_Mutation_p.Q524K	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	526	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CATGACTTTCCAGGAGTTCTT	0.517			NA											13	21					0.00316338	0.00338531	0.003163	1	0
OR2C3	81472	broad.mit.edu	37	1	247695185	247695185	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:247695185A>T	uc009xgy.2	-	2	991	c.629T>A	c.(628-630)CTG>CAG	p.L210Q	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CCCCAGAGGCAGGACAACAAA	0.532			NA											8	22					0	0	0.00308	0	0
OR14A16	284532	broad.mit.edu	37	1	247978138	247978138	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:247978138C>T	uc001idm.1	-	1	894	c.894G>A	c.(892-894)CTG>CTA	p.L298L		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCAACATCCCCAGAGCCACCT	0.358	Ovarian(112;180 1586 15073 21914 33526)		NA											23	43					0	0	0.005443	0	0
OR2M3	127062	broad.mit.edu	37	1	248366414	248366414	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:248366414G>T	uc010pzg.1	+	1	45	c.45G>T	c.(43-45)CTG>CTT	p.L15L		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCATCCTCCTGGGAATCTTCA	0.463			NA											36	206					8.16277e-20	1.41636e-19	0.006999	1	0
OR2T33	391195	broad.mit.edu	37	1	248436676	248436676	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:248436676C>A	uc010pzi.1	-	1	441	c.441G>T	c.(439-441)TGG>TGT	p.W147C		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CACCCAGGAGCCAACACGACA	0.592			NA											24	93					1.55469e-16	2.58778e-16	0.00333	1	0
OR2T33	391195	broad.mit.edu	37	1	248436752	248436752	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:248436752G>T	uc010pzi.1	-	1	365	c.365C>A	c.(364-366)GCG>GAG	p.A122E		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCAGACAGCCGCATAGCGGTC	0.612			NA											5	78					5.18039e-06	6.17778e-06	0.00308	1	0
OR14I1	401994	broad.mit.edu	37	1	248845177	248845177	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:248845177T>A	uc001ieu.1	-	1	429	c.429A>T	c.(427-429)GCA>GCT	p.A143A		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGTGGTGACTGCCATCTGAT	0.532			NA											3	17					0	0	0.004672	0	0
ZNF692	55657	broad.mit.edu	37	1	249144510	249144510	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:249144510C>A	uc001ifc.1	-	12	1626	c.1459G>T	c.(1459-1461)GAG>TAG	p.E487*	ZNF692_uc001iez.1_Nonsense_Mutation_p.E209*|ZNF692_uc001ifa.1_Nonsense_Mutation_p.E209*|ZNF692_uc001ifb.1_Nonsense_Mutation_p.E283*|ZNF692_uc001ifd.1_Nonsense_Mutation_p.E486*|ZNF692_uc001ife.1_RNA|ZNF692_uc001iff.1_Nonsense_Mutation_p.E442*|ZNF692_uc010pzr.1_Nonsense_Mutation_p.E492*	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGACAGGGCTCTAGGGGACCA	0.622			NA											18	120					6.33239e-15	1.02077e-14	0.010504	1	0
CELF2	10659	broad.mit.edu	37	10	11299787	11299787	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:11299787C>A	uc001iki.3	+	5	561	c.469C>A	c.(469-471)CAG>AAG	p.Q157K	CELF2_uc010qbi.1_5'UTR|CELF2_uc010qbj.1_Missense_Mutation_p.Q157K|CELF2_uc001ikk.2_Missense_Mutation_p.Q164K|CELF2_uc001ikl.3_Missense_Mutation_p.Q164K|CELF2_uc010qbk.1_RNA|CELF2_uc010qbl.1_Missense_Mutation_p.Q133K|CELF2_uc010qbm.1_5'UTR|CELF2_uc001iko.3_Missense_Mutation_p.Q133K|CELF2_uc001ikp.3_Missense_Mutation_p.Q133K|CELF2_uc010qbn.1_Missense_Mutation_p.Q141K|CELF2_uc009xiw.1_3'UTR|CELF2_uc010qbo.1_Missense_Mutation_p.Q46K|CELF2_uc010qbp.1_5'UTR	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	157	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 2.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						TCCATTTGGCCAGATAGAAGA	0.478			NA											21	38					1.55795e-14	2.48396e-14	0.001882	1	0
DHTKD1	55526	broad.mit.edu	37	10	12131102	12131102	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:12131102C>T	uc001ild.3	+	5	934	c.835C>T	c.(835-837)CTC>TTC	p.L279F		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	279					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GCACCATCCCCTCCATGTGAC	0.597			NA											19	53					0	0	0.007413	0	0
CUBN	8029	broad.mit.edu	37	10	16957942	16957942	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:16957942C>A	uc001ioo.2	-	46	7140	c.7088G>T	c.(7087-7089)TGT>TTT	p.C2363F		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2363	CUB 17.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGCCACTCACAGAATAAGTT	0.448			NA											14	45					6.94344e-10	9.60243e-10	0.006122	1	0
CUBN	8029	broad.mit.edu	37	10	17152917	17152917	+	Splice_Site	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:17152917C>A	uc001ioo.2	-	9	1067	c.1015_splice	c.e9+1	p.G339_splice		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CGAGGCAGCACCTGGTGGACA	0.483			NA											22	56					8.24728e-16	1.3551e-15	0.004656	1	0
ST8SIA6	338596	broad.mit.edu	37	10	17363209	17363209	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:17363209C>A	uc001ipd.2	-	8	865	c.865G>T	c.(865-867)GAG>TAG	p.E289*	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	289	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						GCTTTAGACTCTTCGAGCGTG	0.448			NA											46	111					8.20599e-20	1.42144e-19	0.002852	1	0
ST8SIA6	338596	broad.mit.edu	37	10	17365138	17365138	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:17365138G>T	uc001ipd.2	-	7	654	c.654C>A	c.(652-654)ACC>ACA	p.T218T	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	218	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						CATCTCCTGTGGTTGGGGGTA	0.289			NA											14	81					3.52763e-06	4.2315e-06	0.00499	1	0
SLC39A12	221074	broad.mit.edu	37	10	18242435	18242435	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:18242435G>A	uc001ipo.2	+	2	503	c.230G>A	c.(229-231)AGG>AAG	p.R77K	SLC39A12_uc001ipn.2_Missense_Mutation_p.R77K|SLC39A12_uc001ipp.2_Missense_Mutation_p.R77K|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	77	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TGCCCACGGAGGAGAAACGGA	0.483			NA											7	22					0	0	0.00308	0	0
SLC39A12	221074	broad.mit.edu	37	10	18280107	18280107	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:18280107C>A	uc001ipo.2	+	8	1570	c.1297C>A	c.(1297-1299)CCA>ACA	p.P433T	SLC39A12_uc001ipn.2_Missense_Mutation_p.P433T|SLC39A12_uc001ipp.2_Missense_Mutation_p.P433T|SLC39A12_uc010qck.1_Missense_Mutation_p.P299T	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	433	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						GCAGGAAGCCCCAGAATTTGG	0.343			NA											21	59					6.44725e-10	8.94042e-10	0.002299	1	0
GPR158	57512	broad.mit.edu	37	10	25886831	25886831	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:25886831C>A	uc001isj.2	+	11	2336	c.2276C>A	c.(2275-2277)ACG>AAG	p.T759K	GPR158_uc001isk.2_Missense_Mutation_p.T134K	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	759	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity	p.T759M(1)		ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AGACGCATTACGGAGATCCCA	0.527			NA											33	58					2.81731e-10	3.93884e-10	0.002096	1	0
YME1L1	10730	broad.mit.edu	37	10	27437936	27437936	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:27437936A>T	uc001iti.2	-	2	249	c.67T>A	c.(67-69)TTC>ATC	p.F23I	YME1L1_uc001itj.2_Missense_Mutation_p.F23I|YME1L1_uc010qdl.1_Missense_Mutation_p.F23I|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Missense_Mutation_p.F23I	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	23					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						GGTGTATGGAAGGCATTGATG	0.368			NA											12	234					0	0	0.00499	0	0
ZNF438	220929	broad.mit.edu	37	10	31138374	31138374	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:31138374T>A	uc010qdz.1	-	7	1395	c.960A>T	c.(958-960)CCA>CCT	p.P320P	ZNF438_uc001ivn.2_Silent_p.P271P|ZNF438_uc010qdy.1_Silent_p.P310P|ZNF438_uc001ivo.3_Splice_Site|ZNF438_uc009xlg.2_Silent_p.P320P|ZNF438_uc001ivp.3_Silent_p.P310P|ZNF438_uc010qea.1_Silent_p.P320P|ZNF438_uc010qeb.1_Silent_p.P320P|ZNF438_uc010qec.1_Intron	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				CCTTAGGTCCTGGTAAAGAAA	0.473			NA											36	80					0	0	0.002836	0	0
ZNF33A	7581	broad.mit.edu	37	10	38344464	38344464	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:38344464G>A	uc001izh.2	+	5	1587	c.1409G>A	c.(1408-1410)TGT>TAT	p.C470Y	ZNF33A_uc001izg.2_Missense_Mutation_p.C471Y|ZNF33A_uc010qev.1_Missense_Mutation_p.C477Y|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	470	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						CCTTTTGAATGTCTTGAGTGT	0.383			NA											5	37					0	0	0.000602	0	0
RBP3	5949	broad.mit.edu	37	10	48387881	48387881	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:48387881C>A	uc001jez.2	-	1	3111	c.2997G>T	c.(2995-2997)AAG>AAT	p.K999N		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	999	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	TATGGGCTGCCTTCAGGTGTG	0.617			NA											28	63					2.12542e-12	3.2038e-12	0.00632	1	0
PCDH15	65217	broad.mit.edu	37	10	55570366	55570366	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:55570366C>A	uc010qhs.1	-	36	4863	c.4468G>T	c.(4468-4470)GAA>TAA	p.E1490*	PCDH15_uc010qhq.1_Nonsense_Mutation_p.E1483*|PCDH15_uc010qhr.1_Nonsense_Mutation_p.E1478*|PCDH15_uc010qht.1_Nonsense_Mutation_p.E1483*|PCDH15_uc010qhu.1_Missense_Mutation_p.R1501S	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCACCATATTCCTCCTGTCCA	0.368			NA								HNSCC(58;0.16)			8	111					0.00448238	0.00478183	0.004482	1	0
PCDH15	65217	broad.mit.edu	37	10	56138550	56138550	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:56138550C>G	uc001jju.1	-	4	705	c.310G>C	c.(310-312)GAT>CAT	p.D104H	PCDH15_uc010qhq.1_Missense_Mutation_p.D109H|PCDH15_uc010qhr.1_Missense_Mutation_p.D104H|PCDH15_uc010qhs.1_Missense_Mutation_p.D109H|PCDH15_uc010qht.1_Missense_Mutation_p.D104H|PCDH15_uc010qhu.1_Missense_Mutation_p.D104H|PCDH15_uc001jjv.1_Missense_Mutation_p.D82H|PCDH15_uc010qhv.1_Missense_Mutation_p.D104H|PCDH15_uc010qhw.1_Missense_Mutation_p.D104H|PCDH15_uc010qhx.1_Missense_Mutation_p.D104H|PCDH15_uc010qhy.1_Missense_Mutation_p.D109H|PCDH15_uc010qhz.1_Missense_Mutation_p.D104H|PCDH15_uc010qia.1_Missense_Mutation_p.D82H|PCDH15_uc010qib.1_Missense_Mutation_p.D82H|PCDH15_uc001jjw.2_Missense_Mutation_p.D104H	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	104	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACATCTCTATCCAGAACTCTT	0.328			NA								HNSCC(58;0.16)			6	68					0	0	0.00308	0	0
RUFY2	55680	broad.mit.edu	37	10	70154087	70154087	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:70154087G>C	uc001job.2	-	5	952	c.625C>G	c.(625-627)CAA>GAA	p.Q209E	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Missense_Mutation_p.Q140E|RUFY2_uc010qiw.1_Missense_Mutation_p.Q116E|RUFY2_uc001jod.1_Missense_Mutation_p.Q174E|RUFY2_uc009xpv.1_Missense_Mutation_p.Q57E|RUFY2_uc001joe.1_Missense_Mutation_p.Q174E	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	223						nucleus	metal ion binding			ovary(1)	1						TCACTTACTTGTGAGTCTAAA	0.423			NA											13	22					0	0	0.00245	0	0
TET1	80312	broad.mit.edu	37	10	70332883	70332883	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:70332883A>G	uc001jok.3	+	2	1293	c.788A>G	c.(787-789)CAA>CGA	p.Q263R		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	263					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						GTTACCTCTCAAGGAAACCCC	0.433			NA											9	64					0	0	0.000978	0	0
CDH23	64072	broad.mit.edu	37	10	73468918	73468918	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:73468918G>A	uc001jrx.3	+	26	3547	c.3170G>A	c.(3169-3171)GGC>GAC	p.G1057D	CDH23_uc001jrz.2_Missense_Mutation_p.G673D	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1057	Cadherin 10.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						ACCGTGGTGGGCCTGGACCGG	0.612			NA											3	45					0	0	0.004672	0	0
CCDC109A	90550	broad.mit.edu	37	10	74628615	74628615	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:74628615G>C	uc001jtc.2	+	5	672	c.651G>C	c.(649-651)CTG>CTC	p.L217L	CCDC109A_uc009xqp.1_RNA|CCDC109A_uc009xqq.1_RNA|CCDC109A_uc010qjy.1_RNA|CCDC109A_uc009xqr.2_Intron|CCDC109A_uc001jtd.2_Silent_p.L168L	NM_138357	NP_612366	Q8NE86	MCU_HUMAN	coiled-coil domain containing 109A	217	Potential.|Mitochondrial matrix (Potential).				elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)					TGGCTCCCCTGGAAAAGGTAA	0.388			NA											5	45					0	0	0.000602	0	0
DLG5	9231	broad.mit.edu	37	10	79603414	79603414	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:79603414C>A	uc001jzk.2	-	6	985	c.915G>T	c.(913-915)ACG>ACT	p.T305T	DLG5_uc001jzj.2_Silent_p.T60T|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_5'Flank	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	305					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TGTCCATGGCCGTGTCATACA	0.542			NA											19	132					2.94398e-08	3.80373e-08	0.007413	1	0
LRIT2	340745	broad.mit.edu	37	10	85982287	85982287	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:85982287G>T	uc001kcy.2	-	3	1050	c.1042C>A	c.(1042-1044)CAG>AAG	p.Q348K	LRIT2_uc010qmc.1_Missense_Mutation_p.Q358K	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	348						integral to membrane				ovary(2)	2						TGTAGGGCCTGGGCAGGCTGG	0.542			NA											4	20					0.00024832	0.000275552	0.009096	1	0
GRID1	2894	broad.mit.edu	37	10	87966366	87966366	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:87966366G>C	uc001kdl.1	-	3	376	c.275C>G	c.(274-276)ACG>AGG	p.T92R	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	92	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GCCAGTGGACGTGACCAAGGC	0.597			NA								Multiple Myeloma(13;0.14)			6	17					0	0	0.001984	0	0
LIPK	643414	broad.mit.edu	37	10	90497489	90497489	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:90497489G>T	uc010qmv.1	+	6	767	c.767G>T	c.(766-768)AGC>ATC	p.S256I		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K precursor	256					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		CGTATTTGCAGCAACTTCCTA	0.393			NA											36	77					4.65686e-17	7.80216e-17	0.003755	1	0
CNNM1	26507	broad.mit.edu	37	10	101122153	101122153	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:101122153G>T	uc001kpp.3	+	4	2317	c.2028G>T	c.(2026-2028)CAG>CAT	p.Q676H	CNNM1_uc009xwe.2_Missense_Mutation_p.Q676H|CNNM1_uc010qpi.1_Missense_Mutation_p.Q676H|CNNM1_uc009xwf.2_Missense_Mutation_p.Q676H|CNNM1_uc009xwg.2_Missense_Mutation_p.Q76H	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	676					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		TGCTTCTACAGGTGAGTAGGA	0.542			NA											11	30					2.80697e-09	3.77464e-09	0.000978	1	0
PDZD7	79955	broad.mit.edu	37	10	102783789	102783789	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:102783789C>A	uc001kso.1	-	3	478	c.263G>T	c.(262-264)CGG>CTG	p.R88L	PDZD7_uc001ksn.2_Missense_Mutation_p.R88L	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	88	PDZ 1.					cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CTTCTCCACCCGGACTGAATG	0.592			NA											17	46					2.48551e-13	3.85461e-13	0.00499	1	0
PDCD11	22984	broad.mit.edu	37	10	105197799	105197799	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:105197799C>T	uc001kwy.1	+	26	3960	c.3873C>T	c.(3871-3873)AAC>AAT	p.N1291N		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1291	S1 motif 11.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CTGCAGACAACGTATTGACTT	0.473			NA											57	144					0	0	0.00361	0	0
SORCS3	22986	broad.mit.edu	37	10	106737195	106737195	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:106737195C>A	uc001kyi.1	+	4	1125	c.898C>A	c.(898-900)CTG>ATG	p.L300M		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	300	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TATCCAGAGCCTGCTCTTTCA	0.458	NSCLC(116;1497 1690 7108 13108 14106)		NA											17	45					1.15919e-05	1.36171e-05	0.008871	1	0
KCNK18	338567	broad.mit.edu	37	10	118957067	118957067	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:118957067G>T	uc010qsr.1	+	1	68	c.68G>T	c.(67-69)GGC>GTC	p.G23V		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	23	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CTCTTCCCTGGCCTCTGCTTC	0.632			NA											8	48					0.000157383	0.000175596	0.00308	1	0
PDZD8	118987	broad.mit.edu	37	10	119044326	119044326	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:119044326C>A	uc001lde.1	-	5	2117	c.1918G>T	c.(1918-1920)GAT>TAT	p.D640Y		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	640					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TCTATGGCATCCACATTTTTT	0.448			NA											9	60					5.4927e-09	7.29032e-09	0.004482	1	0
EMX2	2018	broad.mit.edu	37	10	119305306	119305307	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:119305306_119305307CC>AA	uc001ldh.3	+	2	1393_1394	c.570_571CC>AA	c.(568-573)AGCCTC>AGAATC	p.190_191SL>RI	EMX2OS_uc001ldg.2_5'Flank|EMX2_uc001ldi.3_Intron	NM_004098	NP_004089	Q04743	EMX2_HUMAN	empty spiracles homeobox 2 isoform 1	190_191	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		TGGCACACAGCCTCAGCCTCAC	0.634			NA											3	21					0	0	0.004672	0	0
GRK5	2869	broad.mit.edu	37	10	121203194	121203194	+	Missense_Mutation	SNP	G	G	T	rs143962659	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:121203194G>T	uc001led.2	+	12	1429	c.1196G>T	c.(1195-1197)CGC>CTC	p.R399L	GRK5_uc009xzh.2_Missense_Mutation_p.R264L	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	399	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GAGGTGGACCGCCGGGTCCTG	0.637			NA											10	35					5.50884e-06	6.53894e-06	0.001368	1	0
BAG3	9531	broad.mit.edu	37	10	121431949	121431950	+	Missense_Mutation	DNP	GA	GA	AG			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:121431949_121431950GA>AG	uc001lem.2	+	3	996_997	c.690_691GA>AG	c.(688-693)AAGACG>AAAGCG	p.T231A	BAG3_uc001lel.2_Missense_Mutation_p.T231A	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	231					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AAGCCCAGAAGACGCACTACCC	0.658			NA											3	64					0	0	0.004672	0	0
FAM24A	118670	broad.mit.edu	37	10	124672365	124672365	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:124672365C>A	uc001lgv.2	+	3	334	c.213C>A	c.(211-213)ACC>ACA	p.T71T		NM_001029888	NP_001025059	A6NFZ4	FA24A_HUMAN	family with sequence similarity 24, member A	71						extracellular region				ovary(2)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.124)|COAD - Colon adenocarcinoma(40;0.141)		CCAAAGCCACCACCATGGAGT	0.507			NA											28	53					1.16021e-09	1.58098e-09	0.007291	1	0
DOCK1	1793	broad.mit.edu	37	10	128824628	128824628	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:128824628A>T	uc001ljt.2	+	16	1565	c.1501A>T	c.(1501-1503)ATC>TTC	p.I501F	DOCK1_uc010qun.1_Missense_Mutation_p.I522F	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	501	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GGCCATTCCCATCGAGGACGT	0.438			NA											2	4					0	0	0.004672	0	0
PAOX	196743	broad.mit.edu	37	10	135204895	135204895	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr10:135204895G>T	uc001lmv.2	+	7	1552	c.1472G>T	c.(1471-1473)AGG>ATG	p.R491M	PAOX_uc001lmw.2_RNA|PAOX_uc001lmx.2_Missense_Mutation_p.E438D|PAOX_uc001lmy.2_3'UTR|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA|MTG1_uc001lnd.2_5'Flank	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	629					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TCGGGATGGAGGGAGGCCGAC	0.657			NA											15	72					1.52009e-12	2.30153e-12	0.003163	1	0
MUC5B	727897	broad.mit.edu	37	11	1246915	1246915	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:1246915C>T	uc009ycr.1	+	18	2079	c.1953C>T	c.(1951-1953)ACC>ACT	p.T651T	MUC5B_uc009yct.1_Silent_p.T25T|MUC5B_uc001ltb.2_Silent_p.T25T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	25					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACAGAGACCCAGGGCCCTG	0.652			NA											3	6					0	0	0.004672	0	0
TRPM5	29850	broad.mit.edu	37	11	2427906	2427906	+	Missense_Mutation	SNP	C	C	G	rs148532424		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:2427906C>G	uc001lwm.3	-	21	3245	c.3236G>C	c.(3235-3237)CGG>CCG	p.R1079P	TRPM5_uc010qxl.1_Missense_Mutation_p.R1079P|TRPM5_uc009ydn.2_Missense_Mutation_p.R1081P	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	1079	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGCGGTTTTCCGCAGCACCTC	0.617	NSCLC(1;49 61 17205 18850 43201)		NA											11	69					0	0	0.001855	0	0
OR52M1	119772	broad.mit.edu	37	11	4567362	4567362	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:4567362G>T	uc010qyf.1	+	1	942	c.942G>T	c.(940-942)ATG>ATT	p.M314I		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	314	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGATAGAAATGAAGATTAGAT	0.403			NA											7	43					5.68852e-11	8.1424e-11	0.004482	1	0
HBB	3043	broad.mit.edu	37	11	5246896	5246896	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:5246896G>T	uc001mae.1	-	3	426	c.376C>A	c.(376-378)CCA>ACA	p.P126T		NM_000518	NP_000509	P68871	HBB_HUMAN	beta globin	126					blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	GCCTGCACTGGTGGGGTGAAT	0.498			NA							Sickle_Cell_Trait				23	55					7.41877e-09	9.79585e-09	0.001882	1	0
OR51Q1	390061	broad.mit.edu	37	11	5443936	5443936	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:5443936C>A	uc010qzd.1	+	1	506	c.506C>A	c.(505-507)CCT>CAT	p.P169H	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGCGACTGCCTTTCTGCCAC	0.512			NA											63	131					3.00063e-23	5.40854e-23	0.00361	1	0
OR52E8	390079	broad.mit.edu	37	11	5878090	5878090	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:5878090T>A	uc010qzr.1	-	1	843	c.843A>T	c.(841-843)TTA>TTT	p.L281F	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAGGTTGGCTAATATAATAT	0.393			NA											32	93					0	0	0.002096	0	0
CNGA4	1262	broad.mit.edu	37	11	6262914	6262914	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:6262914G>T	uc001mco.2	+	5	1278	c.1171G>T	c.(1171-1173)GGT>TGT	p.G391C	CNGA4_uc010raa.1_Missense_Mutation_p.G160C|CNGA4_uc001mcn.2_Missense_Mutation_p.G351C	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	391	cNMP.|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATCCGAGAGGGTCAACTGGC	0.537			NA											60	157					2.05175e-36	3.88313e-36	0.00361	1	0
DCHS1	8642	broad.mit.edu	37	11	6651268	6651268	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:6651268G>A	uc001mem.1	-	10	5167	c.4757C>T	c.(4756-4758)TCT>TTT	p.S1586F		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1586	Cadherin 15.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCCCCGCCAGATGCCAGCCG	0.687			NA											4	14					0	0	0.000602	0	0
OR2D3	120775	broad.mit.edu	37	11	6943155	6943155	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:6943155T>G	uc010rav.1	+	1	923	c.923T>G	c.(922-924)TTG>TGG	p.L308W		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	308	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATTTATAGCTTGAGGAACAAA	0.423			NA											33	68					0	0	0.002445	0	0
NLRP14	338323	broad.mit.edu	37	11	7065106	7065106	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:7065106G>T	uc001mfb.1	+	4	2172	c.1849G>T	c.(1849-1851)GTA>TTA	p.V617L		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	617					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ACATTTGCTTGTATCTTCTTT	0.403			NA											37	88					3.33393e-15	5.39981e-15	0.004878	1	0
EIF4G2	1982	broad.mit.edu	37	11	10820818	10820818	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:10820818T>C	uc001mjc.2	-	20	2895	c.2478A>G	c.(2476-2478)CTA>CTG	p.L826L	EIF4G2_uc001mjb.2_Silent_p.L620L|EIF4G2_uc009ygf.2_Silent_p.L620L|EIF4G2_uc001mjd.2_Silent_p.L788L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	826	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CACTGACTTGTAGATCAACGT	0.438			NA											31	54					0	0	0.004289	0	0
ARNTL	406	broad.mit.edu	37	11	13378644	13378644	+	Splice_Site	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:13378644G>T	uc001mkr.2	+	7	629	c.221_splice	c.e7+1	p.R74_splice	ARNTL_uc001mko.2_Splice_Site_p.R31_splice|ARNTL_uc001mkp.2_Splice_Site_p.R74_splice|ARNTL_uc001mkq.2_Splice_Site_p.R74_splice|ARNTL_uc001mks.2_Splice_Site_p.R31_splice|ARNTL_uc001mkt.2_Splice_Site_p.R74_splice|ARNTL_uc001mku.2_Splice_Site|ARNTL_uc009ygm.1_Splice_Site_p.R31_splice|ARNTL_uc001mkv.1_Splice_Site_p.R31_splice|ARNTL_uc001mkw.2_Splice_Site_p.R31_splice|ARNTL_uc001mkx.2_Splice_Site_p.R72_splice	NM_001178	NP_001169	O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear						circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0				Epithelial(150;0.0243)		AAAATGCAAGGTAAGCTTGGA	0.413			NA											14	37					4.7546e-09	6.3519e-09	0.004007	1	0
INSC	387755	broad.mit.edu	37	11	15222397	15222397	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:15222397G>T	uc001mly.2	+	7	908	c.862G>T	c.(862-864)GTT>TTT	p.V288F	INSC_uc001mlz.2_Missense_Mutation_p.V241F|INSC_uc001mma.2_Missense_Mutation_p.V241F|INSC_uc010rcs.1_Missense_Mutation_p.V276F|INSC_uc001mmb.2_Missense_Mutation_p.V241F|INSC_uc001mmc.2_Intron	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	288					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						ACTCTTCAAGGTTTGCCGGCA	0.557			NA											10	33					3.86212e-05	4.42498e-05	0.008291	1	0
MRGPRX3	117195	broad.mit.edu	37	11	18159298	18159298	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:18159298G>T	uc001mnu.2	+	3	910	c.549G>T	c.(547-549)TGG>TGT	p.W183C		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	183	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CAATCGCGTGGCTGGTTTTTT	0.512			NA											6	101					8.12818e-05	9.14868e-05	0.001984	1	0
LDHAL6A	160287	broad.mit.edu	37	11	18485532	18485532	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:18485532G>T	uc001mop.1	+	3	412	c.151G>T	c.(151-153)GTG>TTG	p.V51L	LDHAL6A_uc001moq.2_Missense_Mutation_p.V51L	NM_001144071	NP_001137543	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A	51	NAD (By similarity).				glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	ACTTGTCCTTGTGGATGTTGA	0.378			NA											23	73					2.79863e-10	3.91809e-10	0.004656	1	0
KCNA4	3739	broad.mit.edu	37	11	30033943	30033943	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:30033943C>T	uc001msk.2	-	2	1435	c.283G>A	c.(283-285)GCC>ACC	p.A95T		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	95						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CGGTAGTGGGCTTTCTTCTTC	0.567			NA											17	26					0	0	0.006122	0	0
CHST1	8534	broad.mit.edu	37	11	45671409	45671409	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:45671409G>T	uc001mys.1	-	4	1736	c.1065C>A	c.(1063-1065)GCC>GCA	p.A355A		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	355	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		TCTCGGCCGTGGCCGCCGAGT	0.672			NA											89	46					3.05217e-42	5.8305e-42	0.00361	1	0
MADD	8567	broad.mit.edu	37	11	47345865	47345865	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:47345865C>T	uc001ner.1	+	32	4783	c.4592C>T	c.(4591-4593)GCC>GTC	p.A1531V	MADD_uc001neq.2_Missense_Mutation_p.A1472V|MADD_uc001nev.1_Missense_Mutation_p.A1429V|MADD_uc001nes.1_Missense_Mutation_p.A1449V|MADD_uc001net.1_Missense_Mutation_p.A1492V|MADD_uc009yln.1_Missense_Mutation_p.A1425V|MADD_uc001neu.1_Missense_Mutation_p.A1429V|MADD_uc001nex.2_Missense_Mutation_p.A1531V|MADD_uc001nez.2_Missense_Mutation_p.A1428V|MADD_uc001new.2_Missense_Mutation_p.A1471V|MADD_uc009ylo.2_Missense_Mutation_p.A445V	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1531					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CGCGCTGCCGCCCGACAGCAA	0.587			NA											10	17					0	0	0.008291	0	0
OR4A47	403253	broad.mit.edu	37	11	48510487	48510487	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:48510487C>T	uc010rhx.1	+	1	143	c.143C>T	c.(142-144)ACT>ATT	p.T48I		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTGACCGTAACTGTCAGTGAG	0.403			NA											5	49					0	0	0.00308	0	0
OR4A5	81318	broad.mit.edu	37	11	51411781	51411781	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:51411781C>A	uc001nhi.1	-	1	615	c.615G>T	c.(613-615)ATG>ATT	p.M205I		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				TGAAAATGACCATACAGATTG	0.433			NA											11	42					1.08611e-07	1.37377e-07	0.000978	1	0
OR4A15	81328	broad.mit.edu	37	11	55136162	55136162	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:55136162G>T	uc010rif.1	+	1	803	c.803G>T	c.(802-804)TGT>TTT	p.C268F		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	268	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCTACACCTGTGCATCCCAC	0.423			NA											27	135					2.79863e-10	3.91809e-10	0.004656	1	0
OR4C6	219432	broad.mit.edu	37	11	55432949	55432949	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:55432949C>A	uc001nht.3	+	3	572	c.307C>A	c.(307-309)CAT>AAT	p.H103N	OR4C6_uc010rik.1_Missense_Mutation_p.H103N	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GTTTGTGGAGCATTTCTTTGG	0.532			NA											14	49					0.000219431	0.000244291	0.00245	1	0
OR5D14	219436	broad.mit.edu	37	11	55563911	55563911	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:55563911C>A	uc010rim.1	+	1	880	c.880C>A	c.(880-882)CTA>ATA	p.L294I		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	294	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				GATCTACAGCCTAAGGAATAA	0.408			NA											18	51					1.2644e-06	1.54572e-06	0.010504	1	0
OR5L2	26338	broad.mit.edu	37	11	55594726	55594726	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:55594726A>T	uc001nhy.1	+	1	32	c.32A>T	c.(31-33)GAG>GTG	p.E11V		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				ACTGTGGCTGAGTTCATTCTC	0.428			NA								HNSCC(27;0.073)			88	132					0	0	0.00361	0	0
OR5M8	219484	broad.mit.edu	37	11	56258455	56258455	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:56258455T>A	uc001nix.1	-	1	392	c.392A>T	c.(391-393)TAT>TTT	p.Y131F		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TCTGCTGCCATAAAGCAGAGG	0.517			NA											12	55					0	0	0.001855	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995501	57995501	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:57995501A>T	uc010rkd.1	-	1	847	c.847T>A	c.(847-849)TAC>AAC	p.Y283N		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				ACAAAGGTGTAGACCAACGCG	0.552			NA											14	83					0	0	0.001855	0	0
OR5B3	441608	broad.mit.edu	37	11	58169980	58169980	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:58169980T>A	uc010rkf.1	-	1	903	c.903A>T	c.(901-903)AAA>AAT	p.K301N		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCTCAACAACTTTCTTGAATG	0.423			NA											11	111					0	0	0.001368	0	0
OR5B12	390191	broad.mit.edu	37	11	58207585	58207585	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:58207585C>A	uc010rkh.1	-	1	40	c.40G>T	c.(40-42)GGG>TGG	p.G14W		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCAGTTAACCCCACAAGGATG	0.438			NA											32	54					1.67305e-13	2.59856e-13	0.00623	1	0
SLC15A3	51296	broad.mit.edu	37	11	60714008	60714008	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:60714008C>G	uc001nqn.2	-	2	1078	c.844G>C	c.(844-846)GCC>CCC	p.A282P	SLC15A3_uc001nqo.2_Missense_Mutation_p.A282P	NM_016582	NP_057666	Q8IY34	S15A3_HUMAN	solute carrier family 15, member 3	282					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0						CCTTACCTGGCCGAGTGTCGT	0.622			NA											8	24					0	0	0.00308	0	0
RTN3	10313	broad.mit.edu	37	11	63487648	63487649	+	Missense_Mutation	DNP	GG	GG	TT	rs150093726		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:63487648_63487649GG>TT	uc001nxq.2	+	3	1861_1862	c.1674_1675GG>TT	c.(1672-1677)TTGGTC>TTTTTC	p.558_559LV>FF	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.539_540LV>FF|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.446_447LV>FF|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	558_559					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						TTGAAGAATTGGTCAGTGACTC	0.406			NA											33	27					0	0	0.004672	0	0
MARK2	2011	broad.mit.edu	37	11	63666130	63666130	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:63666130G>T	uc001nxw.2	+	5	967	c.388G>T	c.(388-390)GAG>TAG	p.E130*	MARK2_uc001nxx.2_Nonsense_Mutation_p.E130*|MARK2_uc001nxy.2_Nonsense_Mutation_p.E130*|MARK2_uc001nxv.3_Nonsense_Mutation_p.E130*|MARK2_uc001nxz.3_Nonsense_Mutation_p.E97*|MARK2_uc009yoy.2_Nonsense_Mutation_p.E97*	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	130	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCTTGTCATGGAGTACGCTAG	0.498			NA											39	41					1.00001e-27	1.82828e-27	0.009718	1	0
SF1	7536	broad.mit.edu	37	11	64537758	64537758	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:64537758T>C	uc001obb.1	-	4	736	c.359A>G	c.(358-360)AAT>AGT	p.N120S	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Missense_Mutation_p.N94S|SF1_uc001oaz.1_Missense_Mutation_p.N245S|SF1_uc001oba.1_Missense_Mutation_p.N120S|SF1_uc001obc.1_Missense_Mutation_p.N120S|SF1_uc001obd.1_Missense_Mutation_p.N120S|SF1_uc001obe.1_Missense_Mutation_p.N5S|SF1_uc010rno.1_Missense_Mutation_p.N5S	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	120					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						GAAATCCGGATTGAGTGCAAC	0.547			NA											78	53					0	0	0.00361	0	0
SSSCA1	10534	broad.mit.edu	37	11	65338163	65338163	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:65338163G>A	uc001oek.2	+	2	128	c.108G>A	c.(106-108)CGG>CGA	p.R36R	FAM89B_uc001oen.2_5'Flank|FAM89B_uc001oem.2_5'Flank|FAM89B_uc001oel.2_5'Flank	NM_006396	NP_006387	O60232	SSA27_HUMAN	Sjogren syndrome/scleroderma autoantigen 1	36					cell division|mitosis		protein binding			ovary(1)|skin(1)	2						GCATCTCCCGGCTCATGGGCG	0.672			NA											17	13					0	0	0.00499	0	0
FAT3	120114	broad.mit.edu	37	11	92616381	92616381	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:92616381G>T	uc001pdj.3	+	23	12776	c.12759G>T	c.(12757-12759)GTG>GTT	p.V4253V	FAT3_uc001pdi.3_Silent_p.V693V	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4253	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATAAGATCGTGGACGGGCTGG	0.667			NA								TCGA Ovarian(4;0.039)			60	58					1.88225e-35	3.55575e-35	0.00361	1	0
FOLR4	390243	broad.mit.edu	37	11	94040669	94040669	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:94040669G>T	uc010rud.1	+	4	543	c.543G>T	c.(541-543)AAG>AAT	p.K181N		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	188						extracellular region	folic acid binding|receptor activity			ovary(1)	1						TGTGTGAGAAGACTTGGAGCA	0.607			NA											15	48					1.99824e-07	2.50269e-07	0.00499	1	0
TRPC6	7225	broad.mit.edu	37	11	101375480	101375480	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:101375480C>A	uc001pgk.3	-	2	645	c.220G>T	c.(220-222)GAG>TAG	p.E74*	TRPC6_uc009ywy.2_Nonsense_Mutation_p.E74*|TRPC6_uc009ywz.1_Nonsense_Mutation_p.E74*	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	74	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CTCCCCTTCTCACGGAGAACT	0.463	Colon(166;1315 1927 11094 12848 34731)		NA											62	46					2.40041e-21	4.21516e-21	0.00361	1	0
MMP12	4321	broad.mit.edu	37	11	102738758	102738758	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:102738758G>T	uc001phk.2	-	6	713	c.668C>A	c.(667-669)TCC>TAC	p.S223Y		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	223					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AAGACCTAAGGAATGGCCAAT	0.443			NA											3	4					1.024e-07	1.30165e-07	0.000602	1	0
MMP12	4321	broad.mit.edu	37	11	102745613	102745613	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:102745613G>A	uc001phk.2	-	1	100	c.55C>T	c.(55-57)CTG>TTG	p.L19L		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	19					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	GAGCTGTTCAGGGGAAGAGCT	0.383			NA											5	2					0	0	0.000602	0	0
CWF19L2	143884	broad.mit.edu	37	11	107219763	107219763	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:107219763G>A	uc010rvp.1	-	14	2132	c.2102C>T	c.(2101-2103)CCC>CTC	p.P701L	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	701							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		CCGTACGTTGGGTAAACATAA	0.363			NA											5	24					0	0	0.000602	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110450210	110450210	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:110450210G>A	uc001pkz.1	-	16	3745	c.3460C>T	c.(3460-3462)CTG>TTG	p.L1154L	ARHGAP20_uc001pky.1_Silent_p.L1131L|ARHGAP20_uc009yyb.1_Silent_p.L1118L|ARHGAP20_uc001pla.1_Silent_p.L1118L|ARHGAP20_uc001plb.2_Silent_p.L697L	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1154					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCCCAAGGCAGAGAACCAGAA	0.527			NA											35	42					0	0	0.002445	0	0
ANKK1	255239	broad.mit.edu	37	11	113267990	113267990	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:113267990C>A	uc001pny.2	+	6	977	c.883C>A	c.(883-885)CGT>AGT	p.R295S		NM_178510	NP_848605	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	295							ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		GCTGCAGAGTCGTGTGGCAGT	0.602			NA											10	11					6.40141e-05	7.26916e-05	0.000978	1	0
CEP164	22897	broad.mit.edu	37	11	117209310	117209310	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:117209310G>C	uc001prc.2	+	3	155	c.8G>C	c.(7-9)GGA>GCA	p.G3A	CEP164_uc001prb.2_Missense_Mutation_p.G3A|CEP164_uc001prd.2_Missense_Mutation_p.G3A|CEP164_uc010rxj.1_Intron|CEP164_uc010rxk.1_Missense_Mutation_p.G3A	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	3	Interaction with ATRIP.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GTCATGGCTGGACGACCCCTC	0.502			NA											17	51					0	0	0.00499	0	0
PHLDB1	23187	broad.mit.edu	37	11	118498933	118498933	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:118498933C>T	uc001ptr.1	+	7	1747	c.1394C>T	c.(1393-1395)TCC>TTC	p.S465F	PHLDB1_uc001pts.2_Missense_Mutation_p.S465F|PHLDB1_uc001ptt.2_Missense_Mutation_p.S465F|PHLDB1_uc001ptu.1_Intron|PHLDB1_uc001ptv.1_Missense_Mutation_p.S265F|PHLDB1_uc001ptw.1_5'Flank	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	465											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCATCTCTGTCCCGGCGAGCT	0.677			NA											6	96					0	0	0.001168	0	0
VSIG2	23584	broad.mit.edu	37	11	124618406	124618406	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:124618406C>T	uc001qas.2	-	6	807	c.731G>A	c.(730-732)GGA>GAA	p.G244E	VSIG2_uc001qat.2_Missense_Mutation_p.G244E	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	244	Helical; (Potential).					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		AATCAGAGCTCCGGCCACTCG	0.592			NA											18	18					0	0	0.006122	0	0
HEPN1	641654	broad.mit.edu	37	11	124789651	124789651	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:124789651G>A	uc001qbj.1	+	1	506	c.5G>A	c.(4-6)GGT>GAT	p.G2D	HEPACAM_uc009zbj.2_3'UTR|HEPACAM_uc001qbk.2_3'UTR	NM_001037558	NP_001032647	Q6WQI6	HEPN1_HUMAN	HEPACAM opposite strand 1	2						cytoplasm					0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		GAGGTGATGGGTAACTGGGGC	0.542			NA											19	20					0	0	0.010504	0	0
DYRK4	8798	broad.mit.edu	37	12	4700362	4700362	+	Missense_Mutation	SNP	C	C	A	rs111557443		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:4700362C>A	uc001qmx.2	+	3	176	c.16C>A	c.(16-18)CTC>ATC	p.L6I	DYRK4_uc009zeh.1_Missense_Mutation_p.L121I|DYRK4_uc001qmy.1_Missense_Mutation_p.L6I	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	6						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			GGCCTCAGAGCTCAAGGCTTC	0.483			NA											23	17					7.33532e-06	8.68679e-06	0.003954	1	0
DDX12	440081	broad.mit.edu	37	12	9580280	9580280	+	Silent	SNP	A	A	G	rs146037854	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:9580280A>G	uc010sgs.1	-	14	1626	c.1431T>C	c.(1429-1431)ACT>ACC	p.T477T		NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						AGTCGTTGATAGTCTTCAGCT	0.493			NA											5	39					0	0	0.004482	0	0
ETV6	2120	broad.mit.edu	37	12	12037475	12037475	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:12037475G>T	uc001qzz.2	+	6	1380	c.1106G>T	c.(1105-1107)CGG>CTG	p.R369L	ETV6_uc001raa.1_Intron	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	369	ETS.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				AAAATATTCCGGATAGTGGAT	0.458			NA	T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								74	36					9.07738e-34	1.70849e-33	0.00361	1	0
MGST1	4257	broad.mit.edu	37	12	16510579	16510579	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:16510579G>T	uc001rdf.2	+	3	232	c.167G>T	c.(166-168)GGA>GTA	p.G56V	MGST1_uc001rdg.2_Missense_Mutation_p.G56V|MGST1_uc009zih.1_RNA|MGST1_uc001rdh.2_Missense_Mutation_p.G56V|MGST1_uc001rdi.2_Missense_Mutation_p.G56V	NM_145792	NP_665735	P10620	MGST1_HUMAN	microsomal glutathione S-transferase 1	56	Cytoplasmic (By similarity).				protein homotrimerization|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane	glutathione transferase activity				0		Hepatocellular(102;0.121)			Glutathione(DB00143)	TTTGGCAAAGGAGAAAATGCC	0.313			NA											16	32					5.35267e-07	6.62279e-07	0.007413	1	0
ARID2	196528	broad.mit.edu	37	12	46233111	46233111	+	Splice_Site	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:46233111G>T	uc001ros.1	+	11	1331	c.1331_splice	c.e11-1	p.D444_splice	ARID2_uc001ror.2_Splice_Site_p.D444_splice|ARID2_uc009zkg.1_Splice_Site|ARID2_uc009zkh.1_Intron|ARID2_uc001rot.1_Splice_Site_p.D90_splice	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATTTATTTTAGACATGTTAGT	0.333			NA											14	46					1.05317e-09	1.43896e-09	0.00245	1	0
SLC38A1	81539	broad.mit.edu	37	12	46592512	46592513	+	Missense_Mutation	DNP	CG	CG	AA	rs138242331	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:46592512_46592513CG>AA	uc001rpa.2	-	14	1275_1276	c.1017_1018CG>TT	c.(1015-1020)TCCGAC>TCTTAC	p.D340Y	SLC38A1_uc001rpb.2_Missense_Mutation_p.D340Y|SLC38A1_uc001rpc.2_Missense_Mutation_p.D340Y|SLC38A1_uc001rpd.2_Missense_Mutation_p.D340Y|SLC38A1_uc001rpe.2_Missense_Mutation_p.D340Y|SLC38A1_uc009zkj.1_Missense_Mutation_p.D340Y	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	340	Extracellular (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TGAAGGAGGTCGGACTGCACGT	0.406			NA											37	57					0	0	0.004672	0	0
MLL2	8085	broad.mit.edu	37	12	49444341	49444341	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:49444341C>T	uc001rta.3	-	11	3030	c.3030G>A	c.(3028-3030)GGG>GGA	p.G1010G		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1010	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GAGAAGCCGGCCCCACTGGGG	0.612			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			33	36					0	0	0.006999	0	0
CELA1	1990	broad.mit.edu	37	12	51737560	51737560	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:51737560C>A	uc001ryi.1	-	3	218	c.177G>T	c.(175-177)ATG>ATT	p.M59I		NM_001971	NP_001962	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	59	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			breast(1)	1						GAGCAGCTGTCATCACCCAGT	0.498			NA											6	22					2.7689e-08	3.58658e-08	0.001984	1	0
KRT75	9119	broad.mit.edu	37	12	52818493	52818493	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:52818493G>T	uc001saj.2	-	9	1486	c.1464C>A	c.(1462-1464)AGC>AGA	p.S488R		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	488	Tail.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		CACCTCCAATGCTGCTGCCGC	0.602			NA											51	39					4.78724e-31	8.92803e-31	0.00361	1	0
KRT6B	3854	broad.mit.edu	37	12	52843562	52843563	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:52843562_52843563GG>TT	uc001sak.2	-	4	939_940	c.891_892CC>AA	c.(889-894)TTCCTG>TTAATG	p.297_298FL>LM		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	297_298	Coil 1B.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		AAGGCTCTCAGGAAGTTGATCT	0.5			NA											43	94					0	0	0.004672	0	0
KRT5	3852	broad.mit.edu	37	12	52913777	52913777	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:52913777C>T	uc001san.2	-	1	467	c.304G>A	c.(304-306)GGT>AGT	p.G102S	KRT5_uc009zmh.2_Missense_Mutation_p.G102S	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	102	Head.|Gly-rich.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		aatccactaccggcaccacct	0.249			NA											5	69					0	0	0.000602	0	0
LRP1	4035	broad.mit.edu	37	12	57572802	57572802	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:57572802A>G	uc001snd.2	+	28	5202	c.4736A>G	c.(4735-4737)TAT>TGT	p.Y1579C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1579	EGF-like 7.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACCACCTGCTATGGTAGGAGC	0.632			NA											40	77					0	0	0.009718	0	0
LRP1	4035	broad.mit.edu	37	12	57606328	57606328	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:57606328C>T	uc001snd.2	+	89	14091	c.13625C>T	c.(13624-13626)CCC>CTC	p.P4542L		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4542	Cytoplasmic (Potential).|Interaction with MAFB (By similarity).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ATAGGGGACCCCTTGGCATAG	0.677			NA											12	35					0	0	0.001368	0	0
GLI1	2735	broad.mit.edu	37	12	57864471	57864471	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:57864471G>T	uc001snx.2	+	12	2026	c.1948G>T	c.(1948-1950)GCT>TCT	p.A650S	GLI1_uc009zpq.2_Missense_Mutation_p.A522S	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	650					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TGACCGTCCTGCTCCAGCTAG	0.612	Pancreas(157;841 1936 10503 41495 50368)		NA											11	41					3.86212e-05	4.42498e-05	0.008291	1	0
XPOT	11260	broad.mit.edu	37	12	64815186	64815186	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:64815186G>C	uc001ssb.2	+	9	1441	c.1015G>C	c.(1015-1017)GAG>CAG	p.E339Q	XPOT_uc009zqm.1_Missense_Mutation_p.E249Q	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	339	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		ACTAATTCATGAGGATGATGA	0.299			NA											34	93					0	0	0.002836	0	0
LGR5	8549	broad.mit.edu	37	12	71966695	71966695	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:71966695G>T	uc001swl.2	+	13	1250	c.1202G>T	c.(1201-1203)CGA>CTA	p.R401L	LGR5_uc001swm.2_Missense_Mutation_p.R377L|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	401	LRR 15.|Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						CTTAGCCTCCGATCGCTGTGA	0.423			NA											23	73					7.07758e-08	9.05292e-08	0.004656	1	0
NAV3	89795	broad.mit.edu	37	12	78583961	78583961	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:78583961G>T	uc001syp.2	+	34	6426	c.6253G>T	c.(6253-6255)GCA>TCA	p.A2085S	NAV3_uc001syo.2_Missense_Mutation_p.A2063S|NAV3_uc010sub.1_Missense_Mutation_p.A1542S|NAV3_uc009zsf.2_Missense_Mutation_p.A894S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2085						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AACAGAGGATGCAATTGCCAC	0.353			NA								HNSCC(70;0.22)			22	25					1.22574e-08	1.61016e-08	0.002299	1	0
MYF6	4618	broad.mit.edu	37	12	81101537	81101537	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:81101537C>A	uc001szf.1	+	1	92	c.39C>A	c.(37-39)TTC>TTA	p.F13L		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	13					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CCTATTTCTTCTACTTGGATG	0.493			NA											9	88					3.86212e-05	4.42498e-05	0.008291	1	0
PPFIA2	8499	broad.mit.edu	37	12	81734915	81734915	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:81734915G>T	uc001szo.1	-	20	2496	c.2335C>A	c.(2335-2337)CCT>ACT	p.P779T	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	705										ovary(3)|lung(2)|pancreas(1)	6						AGGGCTCTAGGGGTAGGAGGA	0.453			NA											10	47					0.00136819	0.00148597	0.001368	1	0
PPFIA2	8499	broad.mit.edu	37	12	81751860	81751860	+	Splice_Site	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:81751860C>G	uc001szo.1	-	16	1934	c.1773_splice	c.e16+1	p.K591_splice	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_Splice_Site|PPFIA2_uc010suh.1_Splice_Site|PPFIA2_uc010sui.1_Splice_Site|PPFIA2_uc010suj.1_Splice_Site|PPFIA2_uc009zsi.1_Splice_Site|PPFIA2_uc010suf.1_Splice_Site|PPFIA2_uc009zsh.2_Splice_Site	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2											ovary(3)|lung(2)|pancreas(1)	6						AAAAGATTAACCTTTGGCTCA	0.358			NA											2	13					0	0	0.004672	0	0
SLC6A15	55117	broad.mit.edu	37	12	85260837	85260837	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:85260837A>T	uc001szv.2	-	10	2124	c.1631T>A	c.(1630-1632)GTA>GAA	p.V544E	SLC6A15_uc010sul.1_Missense_Mutation_p.V437E|SLC6A15_uc001szw.1_Missense_Mutation_p.V252E|uc001szx.2_5'Flank	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	544	Helical; Name=10; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						AACAAAGCATACAGCAATATT	0.294			NA											10	27					0	0	0.001368	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85623409	85623409	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:85623409G>C	uc001tac.2	+	25	5048	c.4937G>C	c.(4936-4938)AGT>ACT	p.S1646T		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1646										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GAAACGACTAGTTCCAGAAAT	0.343			NA											13	53					0	0	0.003163	0	0
UTP20	27340	broad.mit.edu	37	12	101748667	101748667	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:101748667A>G	uc001tia.1	+	41	5321	c.5165A>G	c.(5164-5166)GAT>GGT	p.D1722G		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1722					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GAGCGTGTGGATGAGGAAGAG	0.433			NA											41	39					0	0	0.006999	0	0
STAB2	55576	broad.mit.edu	37	12	104126897	104126897	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:104126897C>A	uc001tjw.2	+	51	5583	c.5397C>A	c.(5395-5397)TTC>TTA	p.F1799L	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1799	Extracellular (Potential).|FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ACTTCCTGTTCAACCAAGACA	0.478			NA											89	101					6.01484e-32	1.12585e-31	0.00361	1	0
ACACB	32	broad.mit.edu	37	12	109605836	109605836	+	Missense_Mutation	SNP	G	G	T	rs78715638		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:109605836G>T	uc001tob.2	+	4	1041	c.922G>T	c.(922-924)GCA>TCA	p.A308S	ACACB_uc001toc.2_Missense_Mutation_p.A308S	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	308	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TAAGGCCAACGCAGGTACCTG	0.627			NA											5	34					3.59834e-05	4.1695e-05	0.001168	1	0
CUX2	23316	broad.mit.edu	37	12	111748370	111748370	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:111748370C>A	uc001tsa.1	+	15	1937	c.1784C>A	c.(1783-1785)CCC>CAC	p.P595H		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	595	CUT 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CTAGCCCGGCCCAAGCCCTGG	0.602			NA											39	59					1.07121e-22	1.91394e-22	0.006999	1	0
CIT	11113	broad.mit.edu	37	12	120159163	120159163	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:120159163A>G	uc001txi.1	-	28	3610	c.3557T>C	c.(3556-3558)CTA>CCA	p.L1186P	CIT_uc001txh.1_Missense_Mutation_p.L720P|CIT_uc001txj.1_Missense_Mutation_p.L1228P	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1186	Potential.|Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGTCTTCAGTAGATCAGCCCG	0.448			NA											19	86					0	0	0.010504	0	0
RNF10	9921	broad.mit.edu	37	12	121001251	121001251	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:121001251G>A	uc001typ.3	+	9	1839	c.1356G>A	c.(1354-1356)GAG>GAA	p.E452E	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Silent_p.E363E	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	452					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAGAAGAGGAGGAAGCAGTGT	0.507			NA											20	58					0	0	0.010504	0	0
HPD	3242	broad.mit.edu	37	12	122284813	122284813	+	Silent	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:122284813A>T	uc001ubj.2	-	11	826	c.786T>A	c.(784-786)GCT>GCA	p.A262A	HPD_uc001ubk.2_Silent_p.A223A	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	262					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	GCTGGACCCCAGCGCCCCCGT	0.567			NA											10	23					0	0	0.001368	0	0
SBNO1	55206	broad.mit.edu	37	12	123780522	123780522	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:123780522G>A	uc010tap.1	-	31	4115	c.4115C>T	c.(4114-4116)GCG>GTG	p.A1372V	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.A1371V|SBNO1_uc010taq.1_Missense_Mutation_p.A323V	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1372							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CTGTTGGACCGCAAGCTGTTG	0.433			NA											6	342					0	0	0.001168	0	0
DNAH10	196385	broad.mit.edu	37	12	124268652	124268652	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:124268652C>A	uc001uft.3	+	8	1000	c.975C>A	c.(973-975)ACC>ACA	p.T325T		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	325	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGTGTTCACCGAGTTATTCA	0.488			NA											38	64					2.66277e-13	4.12325e-13	0.006999	1	0
NCOR2	9612	broad.mit.edu	37	12	124824595	124824595	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:124824595C>A	uc010tay.1	-	39	5830	c.5674G>T	c.(5674-5676)GGT>TGT	p.G1892C	NCOR2_uc010taz.1_Missense_Mutation_p.G1876C|NCOR2_uc010tax.1_Missense_Mutation_p.G3C	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	1893					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GTGATGATACCCTTCATGCCT	0.517			NA											33	42					2.20474e-14	3.50972e-14	0.003755	1	0
TMEM132D	121256	broad.mit.edu	37	12	130184920	130184920	+	Silent	SNP	G	G	T	rs138159153	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:130184920G>T	uc009zyl.1	-	2	731	c.403C>A	c.(403-405)CGG>AGG	p.R135R		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	135	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ACTTTGTCCCGCAGGATGTGG	0.537			NA											20	27					8.34094e-07	1.02089e-06	0.008871	1	0
SHISA2	387914	broad.mit.edu	37	13	26621089	26621089	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:26621089C>A	uc001uqm.1	-	2	535	c.450G>T	c.(448-450)CAG>CAT	p.Q150H		NM_001007538	NP_001007539	Q6UWI4	SHSA2_HUMAN	shisa homolog 2 precursor	150	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2						CTCGGCTCTGCTGGGGATCCT	0.622			NA											10	25					1.58986e-06	1.93433e-06	0.008291	1	0
FLT1	2321	broad.mit.edu	37	13	28877397	28877397	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:28877397G>T	uc001usb.3	-	30	4209	c.3924C>A	c.(3922-3924)ACC>ACA	p.T1308T	FLT1_uc010aap.2_Silent_p.T313T|FLT1_uc010aaq.2_Silent_p.T433T|FLT1_uc001usa.3_Silent_p.T526T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1308	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CGTGGTCGTAGGTGAACCTGC	0.572			NA											9	101					4.68919e-08	6.03571e-08	0.008291	1	0
FRY	10129	broad.mit.edu	37	13	32783010	32783010	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:32783010A>T	uc001utx.2	+	32	4535	c.4039A>T	c.(4039-4041)ACA>TCA	p.T1347S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GCGATTCCCCACAACACACCC	0.527			NA											10	73					0	0	0.008291	0	0
BRCA2	675	broad.mit.edu	37	13	32937491	32937491	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:32937491A>G	uc001uub.1	+	18	8379	c.8152A>G	c.(8152-8154)ATT>GTT	p.I2718V		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2718					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAGTGGCCATTATTGAACT	0.398	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			40	219					0	0	0.002852	0	0
WBP4	11193	broad.mit.edu	37	13	41636824	41636824	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:41636824G>A	uc001uxt.2	+	2	160	c.47G>A	c.(46-48)TGC>TAC	p.C16Y	WBP4_uc010tfd.1_Missense_Mutation_p.C16Y	NM_007187	NP_009118	O75554	WBP4_HUMAN	WW domain-containing binding protein 4	16	Matrin-type.				nuclear mRNA cis splicing, via spliceosome	nuclear speck|spliceosomal complex	nucleic acid binding|proline-rich region binding|zinc ion binding			breast(2)|kidney(1)	3		Lung NSC(96;3.55e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;3.11e-09)|Epithelial(112;3.37e-06)|OV - Ovarian serous cystadenocarcinoma(117;8.3e-05)|GBM - Glioblastoma multiforme(144;0.00102)|BRCA - Breast invasive adenocarcinoma(63;0.07)		TGTGATTACTGCAAGTGCTGG	0.368			NA											6	112					0	0	0.00308	0	0
ZC3H13	23091	broad.mit.edu	37	13	46559724	46559724	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:46559724C>A	uc010tfw.1	-	9	1434	c.1428G>T	c.(1426-1428)ATG>ATT	p.M476I	ZC3H13_uc001vas.1_Missense_Mutation_p.M476I|ZC3H13_uc001vat.1_Missense_Mutation_p.M476I	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	476	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TTGAGTCCCGCATGTCTCTGG	0.527	Esophageal Squamous(187;747 2077 11056 31291 44172)		NA											9	273					3.07112e-06	3.68823e-06	0.000978	1	0
PCDH8	5100	broad.mit.edu	37	13	53420300	53420300	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:53420300C>A	uc001vhi.2	-	1	2475	c.2272G>T	c.(2272-2274)GGG>TGG	p.G758W	PCDH8_uc001vhj.2_Missense_Mutation_p.G758W	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	758	Helical; (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GTGCAGCTCCCGGCCAGCACG	0.687	GBM(36;25 841 9273 49207)		NA											37	27					2.40579e-17	4.05729e-17	0.00623	1	0
PCDH8	5100	broad.mit.edu	37	13	53420511	53420511	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:53420511C>A	uc001vhi.2	-	1	2264	c.2061G>T	c.(2059-2061)AGG>AGT	p.R687S	PCDH8_uc001vhj.2_Missense_Mutation_p.R687S	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	687	Extracellular (Potential).|Cadherin 6.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CCAGGAGCGCCCTGAACACGC	0.716	GBM(36;25 841 9273 49207)		NA											12	3					0.000978159	0.00106576	0.000978	1	0
SLITRK1	114798	broad.mit.edu	37	13	84455480	84455480	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:84455480C>A	uc001vlk.2	-	1	1049	c.163G>T	c.(163-165)GCC>TCC	p.A55S		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	55	LRRNT.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAAGTCGGGGCAGTGAAACGC	0.443			NA											38	43					1.02591e-13	1.60563e-13	0.002522	1	0
GPC5	2262	broad.mit.edu	37	13	93518679	93518679	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:93518679C>A	uc010tif.1	+	8	2072	c.1706C>A	c.(1705-1707)CCC>CAC	p.P569H		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	569						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ATGTTACTTCCCGGGATTTGG	0.433			NA											38	53					2.05212e-20	3.57895e-20	0.005524	1	0
DCT	1638	broad.mit.edu	37	13	95095718	95095718	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:95095718A>G	uc001vlv.3	-	7	1780	c.1353T>C	c.(1351-1353)CTT>CTC	p.L451L	DCT_uc010afh.2_Silent_p.L484L	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	451	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AGCTGTAGCCAAGTTGGTCTG	0.433			NA											33	21					0	0	0.004878	0	0
NALCN	259232	broad.mit.edu	37	13	101890223	101890223	+	Nonsense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:101890223A>T	uc001vox.1	-	12	1506	c.1317T>A	c.(1315-1317)TGT>TGA	p.C439*	NALCN_uc001voy.2_Nonsense_Mutation_p.C154*|NALCN_uc001voz.2_Nonsense_Mutation_p.C439*|NALCN_uc001vpa.2_Nonsense_Mutation_p.C439*	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	439	Helical; Name=S2 of repeat II; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TAAATCCCAAACACCATATCT	0.328			NA											39	35					0	0	0.004878	0	0
KDELC1	79070	broad.mit.edu	37	13	103446052	103446052	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:103446052C>A	uc001vpq.3	-	3	877	c.493G>T	c.(493-495)GCA>TCA	p.A165S	KDELC1_uc001vpr.3_5'UTR	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	165						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GGGAAATGTGCCAGATCTCTC	0.463			NA											80	93					9.11151e-29	1.6839e-28	0.00361	1	0
MYO16	23026	broad.mit.edu	37	13	109379843	109379843	+	Missense_Mutation	SNP	A	A	T	rs141525847	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:109379843A>T	uc001vqt.1	+	4	479	c.353A>T	c.(352-354)AAC>ATC	p.N118I	MYO16_uc010agk.1_Missense_Mutation_p.N140I	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	118	ANK 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AGAGGAGTCAACGTCAACCAC	0.408			NA											5	140					0	0	0.000602	0	0
OR4K13	390433	broad.mit.edu	37	14	20502863	20502863	+	Nonsense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:20502863T>A	uc010tkz.1	-	1	55	c.55A>T	c.(55-57)AAA>TAA	p.K19*		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TTTTGAGATTTGGAAAGTCCC	0.383			NA											18	30					0	0	0.008871	0	0
TEP1	7011	broad.mit.edu	37	14	20876106	20876106	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:20876106C>A	uc001vxe.2	-	2	533	c.493G>T	c.(493-495)GGA>TGA	p.G165*	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Nonsense_Mutation_p.G165*	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	165					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGGTCTAGTCCCTTAGAGAAA	0.488			NA											63	165					2.60599e-31	4.86896e-31	0.00361	1	0
ACIN1	22985	broad.mit.edu	37	14	23530581	23530581	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:23530581C>A	uc001wit.3	-	17	3852	c.3524G>T	c.(3523-3525)CGT>CTT	p.R1175L	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.R417L|ACIN1_uc001wiq.3_Missense_Mutation_p.R417L|ACIN1_uc001wir.3_Missense_Mutation_p.R448L|ACIN1_uc001wis.3_Missense_Mutation_p.R856L|ACIN1_uc010akg.2_Missense_Mutation_p.R1162L	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1175	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TGATCGGGAACGGGGCCCTTC	0.577			NA											23	78					6.44725e-10	8.94042e-10	0.002299	1	0
ACIN1	22985	broad.mit.edu	37	14	23531687	23531687	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:23531687T>A	uc001wit.3	-	15	3431	c.3103A>T	c.(3103-3105)ACA>TCA	p.T1035S	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.T277S|ACIN1_uc001wiq.3_Missense_Mutation_p.T277S|ACIN1_uc001wir.3_Missense_Mutation_p.T308S|ACIN1_uc001wis.3_Missense_Mutation_p.T716S|ACIN1_uc010akg.2_Missense_Mutation_p.T1022S	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1035					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		AAGGTTCCTGTGCGCCCCAAC	0.478			NA											45	191					0	0	0.00361	0	0
MYH7	4625	broad.mit.edu	37	14	23893161	23893161	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:23893161C>G	uc001wjx.2	-	23	2983	c.2877G>C	c.(2875-2877)CTG>CTC	p.L959L		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	959	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGGCCAGTGTCAGCTCCAGAT	0.537			NA											17	67					0	0	0.006122	0	0
LRRC16B	90668	broad.mit.edu	37	14	24538064	24538064	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:24538064C>A	uc001wlj.2	+	38	4028	c.3871C>A	c.(3871-3873)CAG>AAG	p.Q1291K	LRRC16B_uc001wlk.2_Missense_Mutation_p.Q344K|CPNE6_uc010tnv.1_5'Flank|CPNE6_uc001wlm.2_5'Flank|CPNE6_uc001wll.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1291										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CCAGCCTCCCCAGGAGCCAGG	0.647			NA											5	13					8.12818e-05	9.14868e-05	0.001984	1	0
IPO4	79711	broad.mit.edu	37	14	24655132	24655132	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:24655132C>T	uc001wmv.1	-	12	1235	c.1104G>A	c.(1102-1104)CAG>CAA	p.Q368Q	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_Silent_p.Q30Q|IPO4_uc001wmx.1_Silent_p.Q232Q|IPO4_uc001wmy.1_Silent_p.Q232Q|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Silent_p.Q368Q	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	368	HEAT 1.				intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		CAGCTTTGCGCTGGTATGGGC	0.602			NA											5	42					0	0	0.00308	0	0
MDGA2	161357	broad.mit.edu	37	14	47566251	47566251	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:47566251A>T	uc001wwj.3	-	6	990	c.794T>A	c.(793-795)GTT>GAT	p.V265D	MDGA2_uc001wwi.3_Missense_Mutation_p.V36D|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	265	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TCCTGTTGTAACACATACTAA	0.438			NA											9	91					0	0	0.008291	0	0
SOS2	6655	broad.mit.edu	37	14	50626482	50626482	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:50626482C>T	uc001wxs.3	-	10	1617	c.1519G>A	c.(1519-1521)GAG>AAG	p.E507K	SOS2_uc010tql.1_Missense_Mutation_p.E474K|SOS2_uc010tqm.1_RNA|SOS2_uc001wxt.2_Missense_Mutation_p.E195K	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	507	PH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TGCTTGTGCTCACAAGTATCT	0.373			NA											20	84					0	0	0.007413	0	0
GNG2	54331	broad.mit.edu	37	14	52433353	52433353	+	Missense_Mutation	SNP	C	C	T	rs139067662	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:52433353C>T	uc001wzi.2	+	4	693	c.164C>T	c.(163-165)CCG>CTG	p.P55L	GNG2_uc001wzh.2_RNA|GNG2_uc010aoc.1_RNA|GNG2_uc001wzj.2_RNA|GNG2_uc001wzk.2_Missense_Mutation_p.P55L	NM_053064	NP_444292	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein),	55					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity				0	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	ACCCCTGTTCCGGCTTCAGAA	0.527			NA											37	99					0	0	0.005524	0	0
PELI2	57161	broad.mit.edu	37	14	56645093	56645093	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:56645093A>G	uc001xch.2	+	2	404	c.118A>G	c.(118-120)AAA>GAA	p.K40E		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	40					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						AGGACGGAGGAAAAGTAGATT	0.468			NA											13	64					0	0	0.003163	0	0
ZBTB25	7597	broad.mit.edu	37	14	64953726	64953726	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:64953726C>A	uc001xhf.2	-	3	1406	c.1223G>T	c.(1222-1224)CGC>CTC	p.R408L	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Missense_Mutation_p.R408L	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	408						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TTGTGACAAGCGAGAACTTTT	0.443			NA											36	57					3.21399e-22	5.70261e-22	0.004878	1	0
ADCK1	57143	broad.mit.edu	37	14	78397954	78397954	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:78397954A>G	uc001xui.2	+	10	1399	c.1300A>G	c.(1300-1302)ACC>GCC	p.T434A	ADCK1_uc001xuj.2_Missense_Mutation_p.T366A|ADCK1_uc001xul.2_Missense_Mutation_p.T141A	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	441	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		CATCTTGAAGACCAACGACCT	0.602			NA											9	22					0	0	0.004482	0	0
TTC7B	145567	broad.mit.edu	37	14	91007748	91007748	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:91007748G>T	uc001xyp.2	-	20	2618	c.2496C>A	c.(2494-2496)CCC>CCA	p.P832P	TTC7B_uc001xyo.2_Silent_p.P276P|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	832							binding			ovary(2)	2		Melanoma(154;0.222)				AGGGCACGGCGGGGCTGCTGG	0.697			NA											8	7					3.86212e-05	4.42498e-05	0.008291	1	0
SERPINA9	327657	broad.mit.edu	37	14	94933527	94933527	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:94933527G>A	uc001ydf.2	-	3	1036	c.875C>T	c.(874-876)CCT>CTT	p.P292L	SERPINA9_uc001yde.2_Missense_Mutation_p.P192L|SERPINA9_uc010avc.2_Missense_Mutation_p.P143L|SERPINA9_uc001ydg.2_Missense_Mutation_p.P256L|SERPINA9_uc001ydh.1_Missense_Mutation_p.P292L|SERPINA9_uc001ydi.1_Missense_Mutation_p.P256L	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	274					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GCCCTTGCTAGGGAGGACAAA	0.522			NA											19	40					0	0	0.008871	0	0
DLK1	8788	broad.mit.edu	37	14	101201093	101201093	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:101201093C>A	uc001yhs.3	+	5	1165	c.1012C>A	c.(1012-1014)CGC>AGC	p.R338S	DLK1_uc001yhu.3_Missense_Mutation_p.R265S	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	338	Cytoplasmic (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				GTCCAACCTGCGCTACAACCA	0.572			NA											17	47					5.3912e-06	6.41421e-06	0.006122	1	0
ADAM6	8755	broad.mit.edu	37	14	106208133	106208133	+	Splice_Site	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:106208133C>G	uc010tyt.1	-	3628		c.58985_splice	c.e3628-1		uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Splice_Site_p.G90_splice|uc001ysf.2_Splice_Site_p.G90_splice					Parts of antibodies, mostly variable regions.												0						CGGGGCTGCCCTGTAGGGACA	0.642			NA											6	146					0	0	0.001168	0	0
C15orf2	23742	broad.mit.edu	37	15	24923730	24923730	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:24923730G>T	uc001ywo.2	+	1	3190	c.2716G>T	c.(2716-2718)GGG>TGG	p.G906W		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	906					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GGCCACTGATGGGCAGCAGAA	0.502			NA											34	46					8.4185e-14	1.32161e-13	0.002445	1	0
GABRB3	2562	broad.mit.edu	37	15	26812800	26812800	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:26812800T>C	uc001zaz.2	-	7	905	c.763A>G	c.(763-765)ATA>GTA	p.I255V	GABRB3_uc010uae.1_Missense_Mutation_p.I170V|GABRB3_uc001zba.2_Missense_Mutation_p.I255V|GABRB3_uc001zbb.2_Missense_Mutation_p.I311V	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	255	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GTTATCAGTATAGAGGGCATA	0.423			NA											19	19					0	0	0.008871	0	0
OCA2	4948	broad.mit.edu	37	15	28000591	28000591	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:28000591G>T	uc001zbh.3	-	24	2570	c.2460C>A	c.(2458-2460)TCC>TCA	p.S820S	OCA2_uc010ayv.2_Silent_p.S796S	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	820	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CAACAGTGCAGGACACAACCA	0.433			NA							Oculocutaneous_Albinism				6	25					5.18039e-06	6.17778e-06	0.00308	1	0
RYR3	6263	broad.mit.edu	37	15	34015043	34015043	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:34015043G>C	uc001zhi.2	+	44	6817	c.6747G>C	c.(6745-6747)AAG>AAC	p.K2249N	RYR3_uc010bar.2_Missense_Mutation_p.K2249N	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2249	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGCCATTAAGATCTCTGAGA	0.577			NA											43	54					0	0	0.003214	0	0
SPRED1	161742	broad.mit.edu	37	15	38591588	38591588	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:38591588G>T	uc001zka.3	+	2	382	c.47G>T	c.(46-48)CGA>CTA	p.R16L		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	16	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AGTTATGCACGAGTGCGAGCT	0.438	Melanoma(196;2146 2959 7698 16532)		NA							Legius_syndrome				4	55					0.00909568	0.00956356	0.009096	1	0
ZSCAN29	146050	broad.mit.edu	37	15	43658617	43658617	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:43658617G>C	uc001zrk.1	-	3	1060	c.913C>G	c.(913-915)CTC>GTC	p.L305V	ZSCAN29_uc001zrj.1_Missense_Mutation_p.L185V|ZSCAN29_uc010bdf.1_Missense_Mutation_p.L304V|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Intron|ZSCAN29_uc001zrm.2_Missense_Mutation_p.L304V	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	305					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		CTCTTCTGGAGACCTTTGAAC	0.562			NA											8	60					0	0	0.00308	0	0
SEMA6D	80031	broad.mit.edu	37	15	48052531	48052531	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:48052531G>A	uc010bek.2	+	3	500	c.140G>A	c.(139-141)CGC>CAC	p.R47H	SEMA6D_uc001zvw.2_Missense_Mutation_p.R47H|SEMA6D_uc001zvx.1_Missense_Mutation_p.R47H|SEMA6D_uc001zvy.2_Missense_Mutation_p.R47H|SEMA6D_uc001zvz.2_Missense_Mutation_p.R47H|SEMA6D_uc001zwa.2_Missense_Mutation_p.R47H|SEMA6D_uc001zwb.2_Missense_Mutation_p.R47H|SEMA6D_uc001zwc.2_Missense_Mutation_p.R47H	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	47	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTTAGAGGACGCCCTTCAGGC	0.423			NA											14	28					0	0	0.00245	0	0
SEMA6D	80031	broad.mit.edu	37	15	48063041	48063041	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:48063041C>G	uc010bek.2	+	19	2641	c.2281C>G	c.(2281-2283)CAT>GAT	p.H761D	SEMA6D_uc001zvw.2_Missense_Mutation_p.H699D|SEMA6D_uc001zvy.2_Missense_Mutation_p.H761D|SEMA6D_uc001zvz.2_Missense_Mutation_p.H705D|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.H699D|SEMA6D_uc001zwc.2_Missense_Mutation_p.H686D	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	761	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GGTAATGGACCATCGAGGGCA	0.478			NA											12	32					0	0	0.001855	0	0
SEMA6D	80031	broad.mit.edu	37	15	48063050	48063050	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:48063050C>A	uc010bek.2	+	19	2650	c.2290C>A	c.(2290-2292)CAA>AAA	p.Q764K	SEMA6D_uc001zvw.2_Missense_Mutation_p.Q702K|SEMA6D_uc001zvy.2_Missense_Mutation_p.Q764K|SEMA6D_uc001zvz.2_Missense_Mutation_p.Q708K|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.Q702K|SEMA6D_uc001zwc.2_Missense_Mutation_p.Q689K	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	764	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CCATCGAGGGCAACCTCCAGA	0.498			NA											16	26					1.5739e-10	2.23406e-10	0.004007	1	0
SLC27A2	11001	broad.mit.edu	37	15	50515330	50515330	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:50515330G>T	uc001zxw.2	+	5	1373	c.1141G>T	c.(1141-1143)GTT>TTT	p.V381F	SLC27A2_uc010bes.2_Missense_Mutation_p.V328F|SLC27A2_uc001zxx.2_Missense_Mutation_p.V146F	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	381	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		AGTTGGTGCTGTTGGAAGAGT	0.373			NA											4	38					2.56e-06	3.08893e-06	0.009096	1	0
UNC13C	440279	broad.mit.edu	37	15	54305103	54305103	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:54305103G>T	uc002ack.2	+	1	3	c.3G>T	c.(1-3)ATG>ATT	p.M1I		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGCTCTCCATGGTGGCTAATT	0.358			NA											7	30					0.000157383	0.000175596	0.00308	1	0
NEDD4	4734	broad.mit.edu	37	15	56142806	56142807	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:56142806_56142807CC>AA	uc002adj.2	-	10	2837_2838	c.2537_2538GG>TT	c.(2536-2538)TGG>TTT	p.W846F	NEDD4_uc002adl.2_Missense_Mutation_p.W427F|NEDD4_uc002adi.2_Missense_Mutation_p.W774F|NEDD4_uc010ugj.1_Missense_Mutation_p.W830F|NEDD4_uc010bfm.2_Missense_Mutation_p.W829F|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	846	Mediates interaction with TNIK (By similarity).|WW 3.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GCCGGACTTCCCAGCCTTTAGG	0.47			NA											62	123					0	0	0.004672	0	0
TLN2	83660	broad.mit.edu	37	15	63004131	63004131	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:63004131G>T	uc002alb.3	+	19	2489	c.2489G>T	c.(2488-2490)CGG>CTG	p.R830L		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	830					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CGCCAGGCGCGGGTTCTGGCC	0.507			NA											13	24					1.5842e-08	2.06776e-08	0.001855	1	0
IGDCC4	57722	broad.mit.edu	37	15	65702613	65702614	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:65702613_65702614CC>AA	uc002aou.1	-	3	675_676	c.465_466GG>TT	c.(463-468)GAGGAG>GATTAG	p.155_156EE>D*		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	155_156	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GTCCCGTTCTCCTCCACCGTCT	0.579			NA											9	38					0	0	0.004672	0	0
SMAD3	4088	broad.mit.edu	37	15	67457257	67457257	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:67457257G>T	uc002aqj.2	+	2	529	c.231G>T	c.(229-231)GTG>GTT	p.V77V	SMAD3_uc010ujr.1_5'UTR|SMAD3_uc010ujs.1_Silent_p.V33V|SMAD3_uc010ujt.1_5'Flank	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	77	MH1.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GGTTGCAGGTGTCCCATCGGA	0.617			NA											16	203					7.07596e-05	8.00845e-05	0.006122	1	0
ITGA11	22801	broad.mit.edu	37	15	68628073	68628073	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:68628073G>T	uc002ari.2	-	12	1474	c.1387C>A	c.(1387-1389)CGG>AGG	p.R463R	ITGA11_uc010bib.2_Silent_p.R463R	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	463	FG-GAP 4.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GTGAGGCTCCGGTTGTTGTGC	0.647			NA											3	10					2.56e-06	3.08893e-06	0.009096	1	0
TMEM202	338949	broad.mit.edu	37	15	72691081	72691081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:72691081C>T	uc002auq.2	+	2	169	c.169C>T	c.(169-171)CGA>TGA	p.R57*	TMEM202_uc002aur.2_Intron	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	57	Helical; (Potential).					integral to membrane				central_nervous_system(1)|skin(1)	2						CATCTACATCCGAACGCTCTG	0.517			NA											7	36					0	0	0.00308	0	0
KIAA1199	57214	broad.mit.edu	37	15	81181089	81181089	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:81181089G>C	uc002bfw.1	+	8	1176	c.916G>C	c.(916-918)GAG>CAG	p.E306Q	KIAA1199_uc010unn.1_Missense_Mutation_p.E306Q	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	306										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GTTCCAGACAGAGCATGGCGA	0.473			NA											10	122					0	0	0.001855	0	0
IL16	3603	broad.mit.edu	37	15	81584983	81584983	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:81584983G>T	uc002bgh.3	+	12	1883	c.1507G>T	c.(1507-1509)GCT>TCT	p.A503S	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.A503S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.A545S|IL16_uc002bgg.2_Missense_Mutation_p.A503S|IL16_uc002bgi.1_5'UTR|IL16_uc002bgj.2_5'UTR|IL16_uc002bgk.2_5'Flank	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	503					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GCATCGCAGGGCTCAGAAGGT	0.602			NA											13	31					4.36969e-10	6.07595e-10	0.001855	1	0
AGBL1	123624	broad.mit.edu	37	15	86807756	86807757	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:86807756_86807757TC>AA	uc002blz.1	+	10	1296_1297	c.1216_1217TC>AA	c.(1216-1218)TCT>AAT	p.S406N	AGBL1_uc002bma.1_Missense_Mutation_p.S137N|AGBL1_uc002bmb.1_Missense_Mutation_p.S100N	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	406					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GAGAGATTCTTCTGAAAGTGAA	0.47			NA											23	60					0	0	0.004672	0	0
ACAN	176	broad.mit.edu	37	15	89398308	89398308	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:89398308C>T	uc010upo.1	+	12	2866	c.2492C>T	c.(2491-2493)CCC>CTC	p.P831L	ACAN_uc010upp.1_Missense_Mutation_p.P831L|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	831					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GAGCCATCCCCCTCAGAGGAA	0.632			NA											5	8					0	0	0.000602	0	0
RHCG	51458	broad.mit.edu	37	15	90021158	90021158	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:90021158G>T	uc002bnz.2	-	6	909	c.885C>A	c.(883-885)ACC>ACA	p.T295T	RHCG_uc002bny.2_Silent_p.T66T|RHCG_uc002boa.2_RNA|RHCG_uc010bnq.1_Silent_p.T179T	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	295	Helical; (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					TCTCAGCAGCGGTACCCACGG	0.617			NA											9	33					5.16669e-11	7.42666e-11	0.000978	1	0
MCTP2	55784	broad.mit.edu	37	15	95001411	95001411	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:95001411G>C	uc002btj.2	+	19	2361	c.2296G>C	c.(2296-2298)GAT>CAT	p.D766H	MCTP2_uc010boj.2_Missense_Mutation_p.D495H|MCTP2_uc010bok.2_Missense_Mutation_p.D711H|MCTP2_uc002btl.2_Missense_Mutation_p.D354H	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	766					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TATGGTACAGGATATTGTTTC	0.328			NA											16	49					0	0	0.00499	0	0
FAM169B	283777	broad.mit.edu	37	15	98995130	98995130	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:98995130C>G	uc002buk.1	-	5	544	c.294G>C	c.(292-294)CGG>CGC	p.R98R		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	98											0						CACAGAAGTCCCGCAGCATGG	0.587			NA											4	12					0	0	0.009096	0	0
IGF1R	3480	broad.mit.edu	37	15	99465614	99465614	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:99465614G>C	uc002bul.2	+	11	2489	c.2439G>C	c.(2437-2439)CTG>CTC	p.L813L	IGF1R_uc010urq.1_Silent_p.L813L|IGF1R_uc010bon.2_Silent_p.L813L|IGF1R_uc010boo.1_5'Flank	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	813	Extracellular (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CTGAGAAGCTGGGCTGCAGCG	0.532			NA											15	53					0	0	0.007413	0	0
LINS1	55180	broad.mit.edu	37	15	101112154	101112154	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:101112154C>A	uc002bwe.2	-	7	1630	c.1339G>T	c.(1339-1341)GAT>TAT	p.D447Y	LINS1_uc002bwd.2_Missense_Mutation_p.D34Y|LINS1_uc002bwf.2_Missense_Mutation_p.D447Y|LINS1_uc002bwg.2_Missense_Mutation_p.D447Y|LINS1_uc002bwh.2_Missense_Mutation_p.D447Y	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	447											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			AGCATGTCATCGTCTTGTTCT	0.448			NA											23	65					1.10923e-09	1.51353e-09	0.00278	1	0
MSLNL	401827	broad.mit.edu	37	16	823010	823010	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:823010C>A	uc002cjz.1	-	11	2175	c.2175G>T	c.(2173-2175)CGG>CGT	p.R725R		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	374	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						AGGTGATGAGCCGCAGCTGAT	0.672			NA											42	58					2.01807e-28	3.70281e-28	0.00361	1	0
RUNDC2A	84127	broad.mit.edu	37	16	12145987	12145987	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:12145987C>T	uc002dbw.1	+	8	1094	c.1032C>T	c.(1030-1032)AGC>AGT	p.S344S	SNX29_uc002dby.3_5'Flank	NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	344				S -> G (in Ref. 1; BAB14033).						ovary(1)	1						ATGTGAAAAGCATCGATGATG	0.478			NA	T	CIITA	PMBL|Hodgkin Lymphona|								20	130					0	0	0.007413	0	0
ACSM2B	348158	broad.mit.edu	37	16	20576096	20576096	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:20576096G>A	uc002dhj.3	-	3	282	c.72C>T	c.(70-72)TAC>TAT	p.Y24Y	ACSM2B_uc002dhk.3_Silent_p.Y24Y|ACSM2B_uc010bwf.1_Silent_p.Y24Y	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	24					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TACTATTAATGTAGAGAGTGC	0.512			NA											12	29					0	0	0.00245	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24979672	24979672	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:24979672C>A	uc002dnb.2	-	6	554	c.461G>T	c.(460-462)AGG>ATG	p.R154M	ARHGAP17_uc002dnc.2_Missense_Mutation_p.R154M|ARHGAP17_uc010vcf.1_Translation_Start_Site|ARHGAP17_uc002dnf.2_Missense_Mutation_p.R62M|ARHGAP17_uc002dng.1_Missense_Mutation_p.R154M	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	154	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		AAGCTGTTACCTGGCTCTGAC	0.493			NA											21	52					0.00278032	0.00298476	0.00278	1	0
IL21R	50615	broad.mit.edu	37	16	27460516	27460516	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:27460516C>A	uc002doq.1	+	9	1762	c.1529C>A	c.(1528-1530)CCC>CAC	p.P510H	IL21R_uc002dor.1_Missense_Mutation_p.P510H|IL21R_uc002dos.1_Missense_Mutation_p.P510H|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	510	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						TTCACCAGCCCCGGGGACGAA	0.652			NA	T	BCL6	NHL								7	55					0.00198382	0.00213417	0.001984	1	0
GTF3C1	2975	broad.mit.edu	37	16	27544624	27544624	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:27544624C>T	uc002dov.1	-	5	877	c.837G>A	c.(835-837)CTG>CTA	p.L279L	GTF3C1_uc002dou.2_Silent_p.L279L	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	279						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCTCTTCCCTCAGCTTTCCCA	0.547			NA											13	70					0	0	0.00499	0	0
ITGAD	3681	broad.mit.edu	37	16	31419214	31419214	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:31419214A>T	uc002ebv.1	+	9	1035	c.986A>T	c.(985-987)CAG>CTG	p.Q329L	ITGAD_uc010vfl.1_Silent_p.A361A|ITGAD_uc010cap.1_Missense_Mutation_p.Q329L|ITGAD_uc002ebw.1_Silent_p.A172A	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	329	Extracellular (Potential).|VWFA.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						AAGCAGCTGCAGGAGAAGATC	0.552			NA											25	42					0	0	0.004656	0	0
ITGAD	3681	broad.mit.edu	37	16	31422636	31422636	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:31422636A>T	uc002ebv.1	+	14	1554	c.1505A>T	c.(1504-1506)CAG>CTG	p.Q502L	ITGAD_uc010cap.1_Missense_Mutation_p.Q503L	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	502	Extracellular (Potential).|FG-GAP 5.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CAGAGGGTGCAGTGGCAGTGT	0.632			NA											29	167					0	0	0.009535	0	0
ABCC12	94160	broad.mit.edu	37	16	48138053	48138053	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:48138053C>G	uc002efc.1	-	20	3246	c.2900G>C	c.(2899-2901)CGC>CCC	p.R967P	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_Intron|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	967	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				ATGGGCCTACCGTAACAGAAT	0.458			NA											14	16					0	0	0.00245	0	0
ZNF423	23090	broad.mit.edu	37	16	49669980	49669980	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:49669980G>T	uc002efs.2	-	5	3381	c.3083C>A	c.(3082-3084)ACA>AAA	p.T1028K	ZNF423_uc010vgn.1_Missense_Mutation_p.T911K	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1028	C2H2-type 24.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGAAGTGACTGTCTGCATGCA	0.612			NA											7	18					0.00198382	0.00213417	0.001984	1	0
ZNF423	23090	broad.mit.edu	37	16	49670412	49670412	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:49670412G>T	uc002efs.2	-	5	2949	c.2651C>A	c.(2650-2652)CCC>CAC	p.P884H	ZNF423_uc010vgn.1_Missense_Mutation_p.P767H	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	884					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GCCGTACATGGGCTCCGACGC	0.612			NA											16	54					1.15088e-07	1.44674e-07	0.004007	1	0
CDH8	1006	broad.mit.edu	37	16	61823358	61823358	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:61823358C>A	uc002eog.1	-	8	1558	c.1306G>T	c.(1306-1308)GAG>TAG	p.E436*	CDH8_uc002eoh.2_Nonsense_Mutation_p.E205*	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	436	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AACTGCCTCTCCAGGTCAGTG	0.418			NA											18	23					0.000132079	0.000148172	0.008871	1	0
CDH11	1009	broad.mit.edu	37	16	65005902	65005902	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:65005902G>A	uc002eoi.2	-	10	1890	c.1456C>T	c.(1456-1458)CCC>TCC	p.P486S	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.P486S|CDH11_uc010vin.1_Missense_Mutation_p.P360S	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	486	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GCAAACTTGGGAGCATTATCG	0.483			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			12	7					0	0	0.000978	0	0
CALB2	794	broad.mit.edu	37	16	71392788	71392788	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:71392788C>G	uc002faa.3	+	1	163	c.93C>G	c.(91-93)GAC>GAG	p.D31E	CALB2_uc010vme.1_RNA|CALB2_uc002fac.3_Missense_Mutation_p.D31E	NM_001740	NP_001731	P22676	CALB2_HUMAN	calbindin 2 isoform 1	31	1 (Probable).|EF-hand 1.						calcium ion binding				0		Ovarian(137;0.125)				TTGACGCAGACGGTCAGTAAA	0.647			NA											7	6					0	0	0.001984	0	0
ZFHX3	463	broad.mit.edu	37	16	72834018	72834018	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:72834018G>C	uc002fck.2	-	8	4548	c.3875C>G	c.(3874-3876)CCT>CGT	p.P1292R	ZFHX3_uc002fcl.2_Missense_Mutation_p.P378R	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1292					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CACCATCTCAGGGGTGGTCAC	0.453			NA											14	35					0	0	0.00245	0	0
SLC43A2	124935	broad.mit.edu	37	17	1494602	1494602	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:1494602T>A	uc002fsv.2	-	8	981	c.892A>T	c.(892-894)ACC>TCC	p.T298S	SLC43A2_uc002fsu.2_Missense_Mutation_p.T298S|SLC43A2_uc002fsw.2_Missense_Mutation_p.T298S|SLC43A2_uc002fsx.2_Missense_Mutation_p.T298S|SLC43A2_uc010vqo.1_Missense_Mutation_p.T161S	NM_152346	NP_689559	Q8N370	LAT4_HUMAN	solute carrier family 43, member 2	298					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		AGGTCGACGGTGGACAGGCAC	0.692			NA											23	29					0	0	0.00333	0	0
PITPNM3	83394	broad.mit.edu	37	17	6364785	6364785	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:6364785T>A	uc002gdd.3	-	18	2549	c.2398A>T	c.(2398-2400)AAC>TAC	p.N800Y	PITPNM3_uc010cln.2_Missense_Mutation_p.N764Y|PITPNM3_uc010clm.2_Missense_Mutation_p.N283Y|PITPNM3_uc002gdc.3_Missense_Mutation_p.N391Y	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	800					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		TGTGGGAAGTTGTGCTGGGAC	0.602			NA											47	67					0	0	0.00361	0	0
DLG4	1742	broad.mit.edu	37	17	7095232	7095232	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:7095232G>A	uc002get.3	-	20	3286	c.2085C>T	c.(2083-2085)CCC>CCT	p.P695P	DLG4_uc010vtm.1_Intron|DLG4_uc010vtn.1_Silent_p.P592P|DLG4_uc010cly.2_Silent_p.P649P|DLG4_uc010vto.1_Silent_p.P692P	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	652	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						CCAGGGAGCGGGGGCGGATGA	0.667			NA											4	94					0	0	0.009096	0	0
DLG4	1742	broad.mit.edu	37	17	7095235	7095235	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:7095235G>C	uc002get.3	-	20	3283	c.2082C>G	c.(2080-2082)CGC>CGG	p.R694R	DLG4_uc010vtm.1_Intron|DLG4_uc010vtn.1_Silent_p.R591R|DLG4_uc010cly.2_Silent_p.R648R|DLG4_uc010vto.1_Silent_p.R691R	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	651	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						GGGAGCGGGGGCGGATGAAGA	0.672			NA											4	96					0	0	0.009096	0	0
C17orf68	80169	broad.mit.edu	37	17	8135134	8135134	+	Splice_Site	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:8135134C>A	uc002gkq.3	-	14	2445	c.2386_splice	c.e14-1	p.V796_splice	C17orf68_uc010cnv.2_Splice_Site	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132						positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						TGAGGTGAACCTGGGAGGATG	0.572			NA											4	47					0.00909568	0.00956356	0.009096	1	0
PIK3R5	23533	broad.mit.edu	37	17	8809052	8809052	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:8809052G>T	uc002glt.2	-	4	274	c.207C>A	c.(205-207)GTC>GTA	p.V69V	PIK3R5_uc010vuz.1_Silent_p.V69V|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Silent_p.V69V|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	69	Heterodimerization (By similarity).				platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						CCTTCTCCTGGACCTGTGGAG	0.562	NSCLC(18;589 615 7696 20311 50332)		NA											4	4					0.00116845	0.00127037	0.001168	1	0
MYH2	4620	broad.mit.edu	37	17	10430338	10430338	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:10430338G>C	uc010coi.2	-	29	4035	c.3907C>G	c.(3907-3909)CTG>GTG	p.L1303V	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.L1303V|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1303	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TGAGACACCAGAGCTTCCTTT	0.383			NA											13	39					0	0	0.001855	0	0
DNAH9	1770	broad.mit.edu	37	17	11865393	11865393	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:11865393C>A	uc002gne.2	+	68	13121	c.13053C>A	c.(13051-13053)AAC>AAA	p.N4351K	DNAH9_uc010coo.2_Missense_Mutation_p.N3569K|DNAH9_uc002gnf.2_Missense_Mutation_p.N663K	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4351					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCTTCTTCAACCCCCAGTCGT	0.547			NA											19	27					1.33834e-09	1.81403e-09	0.007413	1	0
FAM18B2	201158	broad.mit.edu	37	17	15406305	15406305	+	Missense_Mutation	SNP	T	T	G	rs141163711		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:15406305T>G	uc002goq.2	-	6	887	c.704A>C	c.(703-705)CAG>CCG	p.Q235P	CDRT4_uc010vvw.1_Intron|FAM18B2_uc010vvx.1_Intron	NM_145301	NP_660344	Q96ET8	F18B2_HUMAN	hypothetical protein LOC201158 isoform 1	235						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0872)|BRCA - Breast invasive adenocarcinoma(8;0.0581)|READ - Rectum adenocarcinoma(1115;0.0967)		GGGCGCCATCTGTTGGCAGTT	0.587			NA											7	21					0	0	0.001984	0	0
ZNF287	57336	broad.mit.edu	37	17	16456684	16456684	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:16456684T>C	uc002gqi.2	-	6	1225	c.772A>G	c.(772-774)AAG>GAG	p.K258E		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	251					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		GTTTCTTCCTTTGTGAGTTTA	0.358			NA											70	70					0	0	0.00361	0	0
KCNJ12	3768	broad.mit.edu	37	17	21318872	21318872	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:21318872C>A	uc002gyv.1	+	3	923	c.218C>A	c.(217-219)ACC>AAC	p.T73N		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	73	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GACATGTTCACCACCTGTGTG	0.577			NA								Prostate(3;0.18)			9	50					2.17888e-05	2.54784e-05	0.006214	1	0
KIAA0100	9703	broad.mit.edu	37	17	26955577	26955577	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:26955577C>A	uc002hbu.2	-	24	4399	c.4300G>T	c.(4300-4302)GAG>TAG	p.E1434*		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1434						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCAGAGAGCTCCTAAGAAACA	0.433			NA											25	43					2.27525e-19	3.91466e-19	0.003954	1	0
SLC6A4	6532	broad.mit.edu	37	17	28539837	28539837	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:28539837C>T	uc002hey.3	-	9	1669	c.1125G>A	c.(1123-1125)TCG>TCA	p.S375S	SLC6A4_uc010csg.2_5'Flank	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	375	Helical; Name=7; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	TGACAAATCCCGAAACGAAGC	0.552			NA											15	44					0	0	0.004007	0	0
CPD	1362	broad.mit.edu	37	17	28772927	28772927	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:28772927G>T	uc002hfb.1	+	12	2777	c.2762G>T	c.(2761-2763)CGC>CTC	p.R921L	CPD_uc010wbo.1_Missense_Mutation_p.R674L|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	921	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CTCATGTTACGCTCCTCCTCA	0.408			NA											15	89					9.16793e-09	1.20898e-08	0.00499	1	0
NF1	4763	broad.mit.edu	37	17	29654692	29654692	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:29654692A>T	uc002hgg.2	+	38	5777	c.5444A>T	c.(5443-5445)CAG>CTG	p.Q1815L	NF1_uc002hgh.2_Missense_Mutation_p.Q1794L|NF1_uc002hgi.1_Missense_Mutation_p.Q827L|NF1_uc010cso.2_Missense_Mutation_p.Q3L	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1815					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.Q1815*(1)|p.H1814fs*43(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTCATGCACCAGGAGTGTGAA	0.488			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			27	54					0	0	0.008361	0	0
UTP6	55813	broad.mit.edu	37	17	30207728	30207728	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:30207728C>A	uc002hgr.2	-	11	914	c.831G>T	c.(829-831)GTG>GTT	p.V277V	UTP6_uc002hgq.2_Silent_p.V93V|UTP6_uc010cst.2_Silent_p.V126V|UTP6_uc010wbw.1_Silent_p.V277V	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	hepatocellular carcinoma-associated antigen 66	277					rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				CTCGCCTTGCCACATAATCCC	0.463			NA											20	137					1.96292e-10	2.75943e-10	0.010504	1	0
SLFN12L	342615	broad.mit.edu	37	17	33802074	33802074	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:33802074T>C	uc002hjn.2	-	5	2601	c.1722A>G	c.(1720-1722)ACA>ACG	p.T574T		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TTGTTTGAGCTGTTGTCCAAT	0.318			NA											10	22					0	0	0.006214	0	0
SLFN12L	342615	broad.mit.edu	37	17	33806457	33806457	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:33806457C>G	uc002hjn.2	-	3	1738	c.859G>C	c.(859-861)GGT>CGT	p.G287R		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TCATTTAGACCAACGAATAAA	0.328			NA											10	42					0	0	0.008291	0	0
NEUROD2	4761	broad.mit.edu	37	17	37762573	37762573	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:37762573C>A	uc002hry.2	-	2	480	c.280G>T	c.(280-282)GAC>TAC	p.D94Y		NM_006160	NP_006151	Q15784	NDF2_HUMAN	neurogenic differentiation 2	94					cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			TCCGCCTCGTCCAGTCCTtct	0.502			NA											3	1					0.004672	0.00495824	0.004672	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274398	39274398	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:39274398G>T	uc002hvz.2	-	1	209	c.170C>A	c.(169-171)TCT>TAT	p.S57Y		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	57	7.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGCACACAGACTGGCAGCA	0.672			NA											16	22					3.45872e-05	4.03057e-05	0.004007	1	0
KRTAP4-4	84616	broad.mit.edu	37	17	39316477	39316477	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:39316477T>C	uc002hwc.2	-	1	507	c.467A>G	c.(466-468)TAC>TGC	p.Y156C		NM_032524	NP_115913	Q9BYR3	KRA44_HUMAN	keratin associated protein 4.4	156						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ATGGGGCCTGTAGCACCTGGA	0.617			NA											12	28					0	0	0.001368	0	0
STAT3	6774	broad.mit.edu	37	17	40468916	40468916	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:40468916C>G	uc002hzl.1	-	23	2388	c.2148G>C	c.(2146-2148)ACG>ACC	p.T716T	STAT3_uc002hzk.1_Intron|STAT3_uc002hzm.1_Silent_p.T715T|STAT3_uc010wgh.1_Silent_p.T618T|STAT3_uc002hzn.1_Silent_p.T716T|STAT3_uc010cyf.1_5'Flank	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	716					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TGCTGCAGGTCGTTCTGTAGG	0.483			NA							Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				8	54					0	0	0.00308	0	0
EZH1	2145	broad.mit.edu	37	17	40872313	40872313	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:40872313C>G	uc002iaz.2	-	7	787	c.642G>C	c.(640-642)AAG>AAC	p.K214N	EZH1_uc002iba.2_Missense_Mutation_p.K205N|EZH1_uc010wgt.1_Missense_Mutation_p.K144N|EZH1_uc010wgu.1_Missense_Mutation_p.K220N|EZH1_uc010wgv.1_Missense_Mutation_p.K174N|EZH1_uc010wgw.1_Missense_Mutation_p.K75N|EZH1_uc010cyp.2_Missense_Mutation_p.K115N|EZH1_uc010cyq.2_Missense_Mutation_p.K131N|EZH1_uc010cys.2_Missense_Mutation_p.K165N|EZH1_uc010cyo.1_5'UTR|EZH1_uc010cyr.1_5'UTR	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	214					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		GTCGCTTTCTCTTTCTTGTTA	0.448			NA											20	84					0	0	0.00278	0	0
CRHR1	1394	broad.mit.edu	37	17	43906640	43906640	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:43906640C>T	uc010dap.2	+	5	652	c.387C>T	c.(385-387)ATC>ATT	p.I129I	CRHR1_uc010wjx.1_5'UTR|CRHR1_uc002ijp.2_Silent_p.I28I|CRHR1_uc002ijm.2_Silent_p.I129I|CRHR1_uc002ijn.2_Silent_p.I89I|CRHR1_uc010dar.2_Silent_p.I129I|CRHR1_uc010dao.2_Silent_p.I28I|CRHR1_uc010daq.2_5'UTR|CRHR1_uc010das.1_RNA|CRHR1_uc002ijo.1_RNA	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	129	Helical; Name=1; (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		GCCACTGTATCTCCCTGGTGG	0.582	Ovarian(110;57 1568 10207 38216 49865)		NA											10	25					0	0	0.008291	0	0
MYL4	4635	broad.mit.edu	37	17	45299788	45299788	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:45299788G>T	uc002ilg.2	+	6	658	c.530G>T	c.(529-531)GGG>GTG	p.G177V	MYL4_uc002ilh.2_Missense_Mutation_p.G177V	NM_001002841	NP_001002841	P12829	MYL4_HUMAN	atrial/embryonic alkali myosin light chain	177	EF-hand 3.				cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			ovary(2)	2						CTGTTAGCTGGGCAAGAGGAT	0.552			NA											7	54					8.12818e-05	9.14868e-05	0.001984	1	0
COL1A1	1277	broad.mit.edu	37	17	48272811	48272811	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:48272811C>A	uc002iqm.2	-	18	1310	c.1184G>T	c.(1183-1185)GGT>GTT	p.G395V		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	395	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	ACCTTTAGCACCAGGCTGTCC	0.582			NA	T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta				OREG0024559	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	75					7.07596e-05	8.00845e-05	0.006122	1	0
KIF2B	84643	broad.mit.edu	37	17	51900651	51900651	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:51900651C>A	uc002iua.2	+	1	413	c.257C>A	c.(256-258)GCT>GAT	p.A86D		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	86					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CTGGACTCTGCTGAACACCCC	0.572			NA											19	147					2.89027e-11	4.18393e-11	0.002299	1	0
ABCA6	23460	broad.mit.edu	37	17	67130881	67130881	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:67130881G>T	uc002jhw.1	-	5	638	c.463C>A	c.(463-465)CAT>AAT	p.H155N		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	155					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TCCCAGCAATGAGCTGTAAGC	0.383			NA											17	49					1.33834e-09	1.81403e-09	0.007413	1	0
TTYH2	94015	broad.mit.edu	37	17	72240154	72240154	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:72240154G>T	uc002jkc.2	+	6	801	c.770G>T	c.(769-771)TGG>TTG	p.W257L	TTYH2_uc010wqw.1_Missense_Mutation_p.W236L	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	257	Helical; Name=4; (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						CTCCTCAGTTGGGCATCCCTG	0.652			NA											8	52					0.000442599	0.000486383	0.006214	1	0
GPR142	350383	broad.mit.edu	37	17	72368433	72368433	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:72368433C>G	uc010wqy.1	+	4	1083	c.1083C>G	c.(1081-1083)GGC>GGG	p.G361G	GPR142_uc010wqx.1_Silent_p.G273G	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	361	Helical; Name=6; (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TCCTCCTGGGCATCACCACAC	0.662			NA											33	35					0	0	0.003271	0	0
OTOP2	92736	broad.mit.edu	37	17	72921751	72921751	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:72921751G>T	uc010wrp.1	+	4	503	c.414G>T	c.(412-414)CTG>CTT	p.L138L	USH1G_uc002jme.1_5'Flank|USH1G_uc010wro.1_5'Flank|OTOP2_uc002jmf.1_Silent_p.L138L	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	138	Helical; (Potential).					integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					TCAAGATCCTGCACCCCCTCA	0.537			NA											40	54					6.07928e-31	1.1317e-30	0.009718	1	0
MIF4GD	57409	broad.mit.edu	37	17	73262985	73262985	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:73262985G>T	uc002jnr.2	-	6	634	c.505C>A	c.(505-507)CGC>AGC	p.R169S	MIF4GD_uc002jno.2_Missense_Mutation_p.R210S|MIF4GD_uc002jnp.2_Missense_Mutation_p.R203S|MIF4GD_uc002jnq.2_Missense_Mutation_p.R210S			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	169	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			TCATCCATGCGCTGCCCATTC	0.592			NA											15	29					1.02788e-11	1.50717e-11	0.00499	1	0
MIF4GD	57409	broad.mit.edu	37	17	73263869	73263869	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:73263869G>T	uc002jnr.2	-	4	435	c.306C>A	c.(304-306)GTC>GTA	p.V102V	MIF4GD_uc002jno.2_Silent_p.V143V|MIF4GD_uc002jnp.2_Silent_p.V136V|MIF4GD_uc002jnq.2_Silent_p.V143V			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	102	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			TGACATAGCAGACCCAGCCCT	0.622			NA											13	52					1.5842e-08	2.06776e-08	0.001855	1	0
UNC13D	201294	broad.mit.edu	37	17	73836587	73836587	+	Splice_Site	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:73836587C>T	uc002jpp.2	-	9	1133	c.753_splice	c.e9+1	p.Q251_splice	UNC13D_uc010wsk.1_Splice_Site_p.Q251_splice|UNC13D_uc002jpq.1_Splice_Site|UNC13D_uc010dgq.1_Splice_Site_p.Q48_splice	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D						positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			ATCCTCCTCACCTGCAGCCTC	0.622			NA							Familial_Hemophagocytic_Lymphohistiocytosis				30	42					0	0	0.002445	0	0
DCXR	51181	broad.mit.edu	37	17	79994492	79994492	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:79994492C>A	uc002kdg.2	-	5	391	c.376G>T	c.(376-378)GGA>TGA	p.G126*		NM_016286	NP_057370	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	126					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity				0	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CCTGGGACTCCCCGGGCTATT	0.587			NA											12	30					2.27111e-07	2.83058e-07	0.001368	1	0
COLEC12	81035	broad.mit.edu	37	18	346494	346494	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:346494G>T	uc002kkm.2	-	5	1343	c.1128C>A	c.(1126-1128)ACC>ACA	p.T376T		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	376	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CTGTGTGTTTGGTAAGGGTAT	0.458			NA											19	50					2.35188e-11	3.42396e-11	0.006122	1	0
EMILIN2	84034	broad.mit.edu	37	18	2847926	2847926	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:2847926T>A	uc002kln.2	+	2	413	c.254T>A	c.(253-255)CTG>CAG	p.L85Q		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	85	EMI.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CCGTCGGCGCTGGTGTAAGTC	0.478			NA											7	20					0	0	0.00308	0	0
LRRC30	339291	broad.mit.edu	37	18	7231772	7231772	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:7231772G>C	uc010wzk.1	+	1	636	c.636G>C	c.(634-636)CAG>CAC	p.Q212H		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	212	LRR 7.									ovary(1)|liver(1)	2						CCAGCCTGCAGATCTTCATCG	0.547			NA											18	24					0	0	0.010504	0	0
LRRC30	339291	broad.mit.edu	37	18	7231799	7231799	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:7231799C>A	uc010wzk.1	+	1	663	c.663C>A	c.(661-663)ATC>ATA	p.I221I		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	221	LRR 7.									ovary(1)|liver(1)	2						GCAACAACATCCACTCCTTCC	0.567			NA											12	17					7.93312e-07	9.7214e-07	0.00245	1	0
KIAA0802	23255	broad.mit.edu	37	18	8783929	8783929	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:8783929G>T	uc002knr.2	+	6	961	c.819G>T	c.(817-819)GAG>GAT	p.E273D	KIAA0802_uc002knq.2_Missense_Mutation_p.E273D|KIAA0802_uc010dkw.1_Missense_Mutation_p.E111D	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	624	Potential.										0						CCTCCACTGAGCTCCGCCGCC	0.642			NA											46	102					1.51926e-22	2.70502e-22	0.00361	1	0
SPIRE1	56907	broad.mit.edu	37	18	12496079	12496079	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:12496079C>A	uc002kre.2	-	7	1042	c.995G>T	c.(994-996)CGG>CTG	p.R332L	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.R212L|SPIRE1_uc010wzx.1_Missense_Mutation_p.R135L|SPIRE1_uc010wzy.1_Missense_Mutation_p.R332L	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	332						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						CTTTTTTAACCGAGGGGGAAT	0.373			NA											13	71					2.68362e-12	4.01561e-12	0.001368	1	0
DSG2	1829	broad.mit.edu	37	18	29111028	29111028	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:29111028A>T	uc002kwu.3	+	9	1281	c.1093A>T	c.(1093-1095)AGG>TGG	p.R365W		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	365	Extracellular (Potential).|Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			CAAGTCGATTAGGAGTAAATA	0.363			NA											22	48					0	0	0.010504	0	0
FAM59A	64762	broad.mit.edu	37	18	29867399	29867399	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:29867399C>A	uc002kxl.2	-	4	1217	c.1161G>T	c.(1159-1161)TCG>TCT	p.S387S	FAM59A_uc002kxk.1_Silent_p.S387S	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	387										ovary(1)|skin(1)	2						ACACACAGACCGAGAGTCGGT	0.587			NA											12	44					4.3838e-07	5.43719e-07	0.001855	1	0
NOL4	8715	broad.mit.edu	37	18	31599524	31599524	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:31599524C>A	uc010dmi.2	-	6	1043	c.814G>T	c.(814-816)GGG>TGG	p.G272W	NOL4_uc010xbs.1_5'UTR|NOL4_uc002kxr.3_Missense_Mutation_p.G108W|NOL4_uc010xbt.1_Missense_Mutation_p.G198W|NOL4_uc010dmh.2_Missense_Mutation_p.G198W|NOL4_uc010xbu.1_Missense_Mutation_p.G272W|NOL4_uc002kxt.3_Missense_Mutation_p.G272W|NOL4_uc010xbv.1_Missense_Mutation_p.G21W|NOL4_uc010xbw.1_Missense_Mutation_p.G158W	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	272						nucleolus	RNA binding			ovary(3)	3						GAACTGTGCCCCAGAGTCTCA	0.433			NA											12	71					1.15088e-07	1.44674e-07	0.004007	1	0
DTNA	1837	broad.mit.edu	37	18	32407638	32407638	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:32407638G>T	uc010dmn.1	+	10	1093	c.1092G>T	c.(1090-1092)AGG>AGT	p.R364S	DTNA_uc002kxu.2_Missense_Mutation_p.R364S|DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.R364S|DTNA_uc002kxw.2_Missense_Mutation_p.R364S|DTNA_uc002kxx.2_Missense_Mutation_p.R361S|DTNA_uc010dmj.2_Missense_Mutation_p.R361S|DTNA_uc002kxz.2_Missense_Mutation_p.R361S|DTNA_uc002kxy.2_Missense_Mutation_p.R361S|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.R361S|DTNA_uc002kyb.3_Missense_Mutation_p.R361S|DTNA_uc010dmm.2_Missense_Mutation_p.R364S|DTNA_uc010xby.1_Missense_Mutation_p.R111S|DTNA_uc010dmo.2_Missense_Mutation_p.R43S|DTNA_uc002kyd.3_Missense_Mutation_p.R43S|DTNA_uc010xbz.1_Missense_Mutation_p.R43S|DTNA_uc010xca.1_Missense_Mutation_p.R43S|DTNA_uc002kye.2_Missense_Mutation_p.R43S	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	364					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						TTATTACCAGGAGGTAAGTTC	0.438			NA											14	63					0.00185496	0.00201036	0.001855	1	0
SLC14A2	8170	broad.mit.edu	37	18	43204724	43204724	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:43204724C>A	uc010dnj.2	+	3	416	c.95C>A	c.(94-96)TCG>TAG	p.S32*	SLC14A2_uc002lbb.2_Nonsense_Mutation_p.S32*|SLC14A2_uc002lbe.2_Nonsense_Mutation_p.S32*	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	32						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						AGCTGGCCCTCGACATCCCCG	0.572			NA											9	42					3.86212e-05	4.42498e-05	0.008291	1	0
TCEB3C	162699	broad.mit.edu	37	18	44554666	44554666	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:44554666G>T	uc010xdb.1	-	1	1784	c.1548C>A	c.(1546-1548)CCC>CCA	p.P516P	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	516					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						TTTTGTccgcgggcgccgcgt	0.373			NA											6	343					4.3838e-07	5.43719e-07	0.001855	1	0
MAPK4	5596	broad.mit.edu	37	18	48255621	48255621	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:48255621G>C	uc002lev.2	+	6	2161	c.1161G>C	c.(1159-1161)GCG>GCC	p.A387A	MAPK4_uc010xdm.1_Silent_p.A176A|MAPK4_uc010doz.2_3'UTR	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	387					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		CGGGTTCGGCGCCACTGGCTG	0.697			NA											6	12					0	0	0.001168	0	0
DCC	1630	broad.mit.edu	37	18	50432650	50432650	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:50432650C>A	uc002lfe.1	+	3	1236	c.649C>A	c.(649-651)CCA>ACA	p.P217T	DCC_uc010xdr.1_Missense_Mutation_p.P65T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	217	Extracellular (Potential).|Ig-like C2-type 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGCTCGAAATCCAGCCAGCTC	0.483			NA											10	41					0.00829132	0.00875385	0.008291	1	0
DCC	1630	broad.mit.edu	37	18	51025666	51025666	+	Splice_Site	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:51025666A>G	uc002lfe.1	+	27	4486	c.3899_splice	c.e27-2	p.S1300_splice	DCC_uc010dpf.1_Splice_Site_p.T933_splice	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCTCCACTGCAGCAGTGAGTG	0.498			NA											7	36					0	0	0.00308	0	0
WDR7	23335	broad.mit.edu	37	18	54444111	54444111	+	Missense_Mutation	SNP	G	G	T	rs113781282		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:54444111G>T	uc002lgk.1	+	17	3158	c.2947G>T	c.(2947-2949)GGT>TGT	p.G983C	WDR7_uc010dpk.1_Intron|WDR7_uc002lgl.1_Intron	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	983										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		AGTAAATGAAGGTATCTCTCT	0.418			NA											27	107					7.38237e-10	1.01819e-09	0.00632	1	0
PHLPP1	23239	broad.mit.edu	37	18	60563197	60563197	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:60563197G>C	uc002lis.2	+	7	1039	c.861G>C	c.(859-861)AGG>AGC	p.R287S		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	799	LRR 7.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						AGACCCTTAGGCTACAGGCTT	0.383			NA											8	32					0	0	0.00308	0	0
SERPINB12	89777	broad.mit.edu	37	18	61234152	61234152	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:61234152G>T	uc010xen.1	+	7	1126	c.1126G>T	c.(1126-1128)GTG>TTG	p.V376L	SERPINB12_uc010xeo.1_Missense_Mutation_p.V396L	NM_080474	NP_536722	Q96P63	SPB12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	376					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity				0						ACGATCTTGGGTGGAGTTTAA	0.463			NA											22	45					2.32416e-17	3.9261e-17	0.002299	1	0
CDH7	1005	broad.mit.edu	37	18	63526277	63526277	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:63526277G>A	uc002ljz.2	+	9	1814	c.1489G>A	c.(1489-1491)GGG>AGG	p.G497R	CDH7_uc002lka.2_Missense_Mutation_p.G497R|CDH7_uc002lkb.2_Missense_Mutation_p.G497R	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	497	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TGCCCAGCCGGGGCAGGTAAG	0.428			NA											11	33					0	0	0.001368	0	0
CDH19	28513	broad.mit.edu	37	18	64211979	64211979	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:64211979C>T	uc002lkc.1	-	6	1075	c.937G>A	c.(937-939)GAA>AAA	p.E313K	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.E313K|CDH19_uc002lkd.2_Missense_Mutation_p.E313K	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	313	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ACTATTCCTTCTTGAGTTTCA	0.308			NA											6	13					0	0	0.001984	0	0
ZNF516	9658	broad.mit.edu	37	18	74154222	74154223	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:74154222_74154223CA>AG	uc010dqx.1	-	2	1023_1024	c.788_789TG>CT	c.(787-789)CTG>CCT	p.L263P	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	263	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TGTGCGCCTTCAGGAACCAGGT	0.653			NA											5	21					0	0	0.004672	0	0
ZNF236	7776	broad.mit.edu	37	18	74624286	74624286	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr18:74624286G>T	uc002lmi.2	+	17	3084	c.2886G>T	c.(2884-2886)CAG>CAT	p.Q962H	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	962					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		ACGAGGACCAGAGCAGGCGCT	0.542			NA											4	15					0.00024832	0.000275552	0.009096	1	0
TMIGD2	126259	broad.mit.edu	37	19	4292732	4292732	+	Nonsense_Mutation	SNP	G	G	T	rs144046862		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:4292732G>T	uc002lzx.1	-	5	759	c.713C>A	c.(712-714)TCA>TAA	p.S238*	TMIGD2_uc010dtv.1_Nonsense_Mutation_p.S234*	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	238	Pro-rich.|Cytoplasmic (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		gcagggTCTTGACGCCAGGTG	0.498			NA											23	21					1.96895e-08	2.55364e-08	0.00278	1	0
RANBP3	8498	broad.mit.edu	37	19	5933469	5933469	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:5933469C>T	uc002mdw.2	-	6	655	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	RANBP3_uc002mdv.2_5'UTR|RANBP3_uc002mdx.2_Missense_Mutation_p.R143Q|RANBP3_uc002mdy.2_Missense_Mutation_p.R75Q|RANBP3_uc002mdz.2_Missense_Mutation_p.R75Q|RANBP3_uc010duq.2_Missense_Mutation_p.R53Q|RANBP3_uc002mea.2_Missense_Mutation_p.R15Q|RANBP3_uc010xix.1_Missense_Mutation_p.R15Q	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	143					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						TGGCTTCAACCGGAAGCCACT	0.622			NA											4	41					0	0	0.000602	0	0
ACTL9	284382	broad.mit.edu	37	19	8808271	8808271	+	Missense_Mutation	SNP	C	C	A	rs142929347		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:8808271C>A	uc002mkl.2	-	1	902	c.781G>T	c.(781-783)GTG>TTG	p.V261L		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	261						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						TCGGAGGCCACGTAGCAATAG	0.647			NA											16	28					4.7546e-09	6.3519e-09	0.004007	1	0
MUC16	94025	broad.mit.edu	37	19	9060278	9060278	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:9060278G>T	uc002mkp.2	-	3	27372	c.27168C>A	c.(27166-27168)GAC>GAA	p.D9056E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9058	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGTGGATATGTCTTGTGACA	0.493			NA											28	38					1.39806e-14	2.23601e-14	0.008361	1	0
MUC16	94025	broad.mit.edu	37	19	9072943	9072943	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:9072943C>A	uc002mkp.2	-	3	14707	c.14503G>T	c.(14503-14505)GTG>TTG	p.V4835L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4837	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGTCCCCACATTGGTAACT	0.453			NA											29	35					4.22769e-11	6.11132e-11	0.00632	1	0
COL5A3	50509	broad.mit.edu	37	19	10091370	10091370	+	Splice_Site	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:10091370T>C	uc002mmq.1	-	35	2646	c.2560_splice	c.e35-1	p.G854_splice		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CACATCGCCCTAGGACAGAGT	0.453			NA											5	15					0	0	0.00308	0	0
KEAP1	9817	broad.mit.edu	37	19	10610293	10610293	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:10610293G>T	uc002moq.1	-	2	573	c.417C>A	c.(415-417)TTC>TTA	p.F139L	KEAP1_uc002mor.1_Missense_Mutation_p.F139L	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	139	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCGTGTAGGCGAATTCAATGA	0.582			NA											10	16					7.48243e-07	9.20222e-07	0.006214	1	0
SMARCA4	6597	broad.mit.edu	37	19	11138491	11138491	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:11138491G>T	uc002mqf.3	+	24	3531	c.3247G>T	c.(3247-3249)GAG>TAG	p.E1083*	SMARCA4_uc010dxp.2_Nonsense_Mutation_p.E1083*|SMARCA4_uc010dxo.2_Nonsense_Mutation_p.E1083*|SMARCA4_uc002mqg.1_Nonsense_Mutation_p.E1083*|SMARCA4_uc010dxq.2_Nonsense_Mutation_p.E1083*|SMARCA4_uc010dxr.2_Nonsense_Mutation_p.E1083*|SMARCA4_uc002mqj.3_Nonsense_Mutation_p.E1083*|SMARCA4_uc010dxs.2_Nonsense_Mutation_p.E1083*|SMARCA4_uc010dxt.1_Nonsense_Mutation_p.E303*|SMARCA4_uc002mqh.3_Nonsense_Mutation_p.E206*|SMARCA4_uc002mqi.1_Nonsense_Mutation_p.E286*	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1083					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGGTAAATTTGAGCTTCTTGA	0.517			NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				37	35					1.69901e-12	2.56483e-12	0.005524	1	0
MYO9B	4650	broad.mit.edu	37	19	17283219	17283219	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:17283219G>C	uc010eak.2	+	12	2019	c.1867G>C	c.(1867-1869)GGC>CGC	p.G623R	MYO9B_uc002nfi.2_Missense_Mutation_p.G623R|MYO9B_uc002nfj.1_Missense_Mutation_p.G623R	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	623	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GTACTTCCTGGGCACCCCGGT	0.542			NA											9	11					0	0	0.006214	0	0
UNC13A	23025	broad.mit.edu	37	19	17758111	17758111	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:17758111G>A	uc002nhd.2	-	17	2271	c.2271C>T	c.(2269-2271)GAC>GAT	p.D757D		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	669	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TGGACGTGCCGTCCAGCACGC	0.632			NA											3	5					0	0	0.004672	0	0
NCAN	1463	broad.mit.edu	37	19	19339042	19339042	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:19339042G>T	uc002nlz.2	+	8	2712	c.2613G>T	c.(2611-2613)ACG>ACT	p.T871T	NCAN_uc010ecc.1_Silent_p.T435T	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	871					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding	p.T871M(1)		ovary(4)	4			Epithelial(12;0.00544)			GCATTGTGACGCCCCTCACGA	0.582			NA											24	29					7.87624e-14	1.2403e-13	0.00278	1	0
ZNF708	7562	broad.mit.edu	37	19	21476272	21476272	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:21476272G>T	uc002npq.1	-	4	1694	c.1496C>A	c.(1495-1497)ACT>AAT	p.T499N	ZNF708_uc002npr.1_Missense_Mutation_p.T435N|ZNF708_uc010ecs.1_Missense_Mutation_p.T435N	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						TTTCTCTCCAGTATGAATTAT	0.353			NA											10	17					0.00829132	0.00875385	0.008291	1	0
ZNF208	7757	broad.mit.edu	37	19	22156742	22156742	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:22156742C>A	uc002nqp.2	-	4	1243	c.1094G>T	c.(1093-1095)GGA>GTA	p.G365V	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGGTTTCTCTCCAGTATGAAT	0.388			NA											15	17					1.67942e-08	2.18924e-08	0.006122	1	0
ZNF676	163223	broad.mit.edu	37	19	22363512	22363512	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:22363512G>T	uc002nqs.1	-	3	1325	c.1007C>A	c.(1006-1008)CCC>CAC	p.P336H		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ACATTTGTAGGGTTTCTCTCC	0.413			NA											18	42					2.94398e-08	3.80373e-08	0.007413	1	0
ZNF98	148198	broad.mit.edu	37	19	22586234	22586234	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:22586234T>A	uc002nqt.2	-	2	233	c.111A>T	c.(109-111)TTA>TTT	p.L37F		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CATTCCTATATAAATTCTGCT	0.388			NA											8	70					0	0	0.00308	0	0
ZNF536	9745	broad.mit.edu	37	19	30935025	30935025	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:30935025G>T	uc002nsu.1	+	2	694	c.556G>T	c.(556-558)GGC>TGC	p.G186C	ZNF536_uc010edd.1_Missense_Mutation_p.G186C	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGGCAACCTGGGCAAGGGGCG	0.667			NA											12	17					7.03913e-09	9.30658e-09	0.001368	1	0
CD22	933	broad.mit.edu	37	19	35829249	35829249	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:35829249C>G	uc010edt.2	+	6	1241	c.1164C>G	c.(1162-1164)CCC>CCG	p.P388P	CD22_uc010xst.1_Silent_p.P216P|CD22_uc010edu.2_Intron|CD22_uc010edv.2_Silent_p.P388P|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	388	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AGATCCTCCCCTGGCACGCTG	0.532	Ovarian(42;1009 1133 23674 26041)		NA											6	84					0	0	0.001168	0	0
LIN37	55957	broad.mit.edu	37	19	36245208	36245208	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:36245208G>C	uc002obm.2	+	9	761	c.647G>C	c.(646-648)CGC>CCC	p.R216P	uc002obl.2_5'Flank	NM_019104	NP_061977	Q96GY3	LIN37_HUMAN	lin-37 homolog	216							protein binding				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGCTGGAAACGCATCCGCCAG	0.637			NA											39	49					0	0	0.00623	0	0
ZFP14	57677	broad.mit.edu	37	19	36832249	36832249	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:36832249G>T	uc002odx.1	-	4	572	c.479C>A	c.(478-480)ACT>AAT	p.T160N	ZFP14_uc010xtd.1_Missense_Mutation_p.T161N|ZFP14_uc010eex.1_Missense_Mutation_p.T160N	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	160					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					CTGATACTCAGTAAGAAAATT	0.388			NA											22	222					1.22574e-08	1.61016e-08	0.002299	1	0
ZNF461	92283	broad.mit.edu	37	19	37129923	37129923	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:37129923C>A	uc002oem.2	-	6	1552	c.1324G>T	c.(1324-1326)GAG>TAG	p.E442*	ZNF461_uc002oen.2_Nonsense_Mutation_p.E411*|ZNF461_uc010xtj.1_Nonsense_Mutation_p.E419*	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	442	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCCTTACACTCATAGGGTTTC	0.408			NA											21	36					4.96729e-08	6.3776e-08	0.008871	1	0
ZNF585B	92285	broad.mit.edu	37	19	37677515	37677515	+	Silent	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:37677515A>T	uc002ofq.2	-	5	1178	c.924T>A	c.(922-924)ATT>ATA	p.I308I	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Silent_p.I122I	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	308	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTGACTTGGAAATGAAGGATT	0.418	Melanoma(93;882 1454 18863 28917 48427)		NA											51	209					0	0	0.00361	0	0
ZNF546	339327	broad.mit.edu	37	19	40504258	40504258	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:40504258G>T	uc002oms.2	+	3	281	c.25G>T	c.(25-27)GGG>TGG	p.G9W	ZNF546_uc002omt.2_Intron	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCCTCTTCACGGGCCTCCAAA	0.428			NA											15	40					1.52009e-12	2.30153e-12	0.003163	1	0
MAP3K10	4294	broad.mit.edu	37	19	40704286	40704286	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:40704286G>T	uc002ona.2	+	2	975	c.687G>T	c.(685-687)CTG>CTT	p.L229L	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	229	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						CCACAGTCCTGATCCTGGAGG	0.612			NA											6	25					3.59834e-05	4.1695e-05	0.001168	1	0
ADCK4	79934	broad.mit.edu	37	19	41206254	41206254	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:41206254C>A	uc002oor.2	-	11	1298	c.996G>T	c.(994-996)CTG>CTT	p.L332L	ADCK4_uc002oop.1_Silent_p.L9L|ADCK4_uc002ooq.1_Silent_p.L291L	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	332	Protein kinase.					integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GGCACTGGTCCAGGGGGACCC	0.662			NA											5	67					0.00116845	0.00127037	0.001168	1	0
CYP2B6	1555	broad.mit.edu	37	19	41522649	41522649	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:41522649C>T	uc002opr.1	+	9	1400	c.1393C>T	c.(1393-1395)CCA>TCA	p.P465S	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.P265S	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	465					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CCCCGTGGCCCCAGAAGACAT	0.587			NA											12	33					0	0	0.001368	0	0
ZNF45	7596	broad.mit.edu	37	19	44417580	44417580	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:44417580C>G	uc002oxu.1	-	4	2107	c.2008G>C	c.(2008-2010)GAC>CAC	p.D670H	ZNF45_uc002oxw.1_Missense_Mutation_p.D670H|ZNF45_uc002oxv.1_Missense_Mutation_p.D670H	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	670					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GAAGGAAAGTCCTTGTCACCC	0.398			NA											22	65					0	0	0.00278	0	0
ZNF155	7711	broad.mit.edu	37	19	44501580	44501580	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:44501580G>C	uc002oxy.1	+	5	1776	c.1571G>C	c.(1570-1572)CGC>CCC	p.R524P	ZNF155_uc002oxz.1_Missense_Mutation_p.R524P|ZNF155_uc010xwt.1_Missense_Mutation_p.R535P|uc010ejc.1_RNA	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	524						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				TACAAGAGGCGCTTGAATCTG	0.289	NSCLC(61;554 1277 20909 42067 42312)		NA											34	36					0	0	0.004878	0	0
RSPH6A	81492	broad.mit.edu	37	19	46299364	46299364	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:46299364T>C	uc002pdm.2	-	6	2060	c.1917A>G	c.(1915-1917)AAA>AAG	p.K639K	RSPH6A_uc002pdl.2_Silent_p.K375K	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	639	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						TCTCAAACTTTCTGGAGAAGC	0.428			NA											29	107					0	0	0.00632	0	0
CRX	1406	broad.mit.edu	37	19	48343139	48343139	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:48343139C>A	uc002phq.3	+	4	1019	c.815C>A	c.(814-816)CCC>CAC	p.P272H		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	272					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		TTCAAGGACCCCACGGGCACC	0.587	Pancreas(57;461 1196 22201 40716 47188)		NA											53	151					5.39261e-20	9.37287e-20	0.00361	1	0
SNRNP70	6625	broad.mit.edu	37	19	49610944	49610944	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:49610944G>T	uc002pmk.2	+	9	1079	c.640G>T	c.(640-642)GAT>TAT	p.D214Y	SNRNP70_uc002pmh.1_RNA|SNRNP70_uc002pmi.1_Missense_Mutation_p.D214Y|SNRNP70_uc002pml.2_5'UTR|SNRNP70_uc002pmm.2_RNA	NM_003089	NP_003080	P08621	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa	214					nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						TTCAGGCCGCGATGACACCTC	0.657			NA											21	46					1.96292e-10	2.75943e-10	0.010504	1	0
SHANK1	50944	broad.mit.edu	37	19	51220046	51220046	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:51220046C>A	uc002psx.1	-	1	150	c.131G>T	c.(130-132)GGC>GTC	p.G44V		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	44					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TGCCCCACTGCCCTGGCCCCG	0.682			NA											5	22					0.000602214	0.000660368	0.000602	1	0
KLK4	9622	broad.mit.edu	37	19	51411735	51411735	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:51411735C>A	uc002pua.1	-	4	492	c.492G>T	c.(490-492)GTG>GTT	p.V164V	KLK4_uc002pty.1_Intron|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_Silent_p.V69V|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_Missense_Mutation_p.C97F|KLK4_uc002pud.1_Silent_p.V69V	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	164	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		CGCACTGCAGCACGGTAGGCA	0.642			NA											34	43					3.11337e-16	5.14034e-16	0.002836	1	0
ZNF816A	125893	broad.mit.edu	37	19	53454041	53454041	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:53454041T>A	uc002qal.1	-	5	1288	c.987A>T	c.(985-987)AGA>AGT	p.R329S	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.R313S	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	329	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TACGATGGCATCTAAGGGATG	0.423			NA											53	159					0	0	0.00361	0	0
ZNF845	91664	broad.mit.edu	37	19	53855101	53855101	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:53855101C>G	uc010ydv.1	+	4	1290	c.1173C>G	c.(1171-1173)ACC>ACG	p.T391T	ZNF845_uc010ydw.1_Silent_p.T391T	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	391	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCAGCAGGACCTTTAGTCGGA	0.393			NA											42	58					0	0	0.00361	0	0
ZNF761	388561	broad.mit.edu	37	19	53952873	53952873	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:53952873A>T	uc010eqp.2	+	5	582	c.124A>T	c.(124-126)AGG>TGG	p.R42W	ZNF761_uc002qbr.2_RNA|ZNF761_uc010ydy.1_5'UTR|ZNF761_uc002qbs.2_RNA|ZNF761_uc002qbt.1_5'Flank	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		GGAGAATTATAGGAACCTGGT	0.433			NA											12	41					0	0	0.00245	0	0
PRKCG	5582	broad.mit.edu	37	19	54401818	54401818	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:54401818G>T	uc002qcq.1	+	11	1499	c.1217G>T	c.(1216-1218)GGG>GTG	p.G406V	PRKCG_uc010yef.1_3'UTR|PRKCG_uc010yeg.1_Missense_Mutation_p.G406V|PRKCG_uc010yeh.1_Missense_Mutation_p.G293V	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	406	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CTGGCGCTGGGGGGCCGGGGT	0.647			NA											12	14					5.16669e-11	7.42666e-11	0.000978	1	0
LILRB5	10990	broad.mit.edu	37	19	54758731	54758731	+	Nonsense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:54758731A>T	uc002qex.2	-	6	1233	c.1122T>A	c.(1120-1122)TAT>TAA	p.Y374*	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Nonsense_Mutation_p.Y365*|LILRB5_uc002qey.2_Nonsense_Mutation_p.Y374*|LILRB5_uc002qez.2_Nonsense_Mutation_p.Y274*|LILRB5_uc002qfa.1_Nonsense_Mutation_p.Y264*|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	374	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCTGGTGTCTATAAGACTGGT	0.537			NA											28	36					0	0	0.002096	0	0
SAPS1	22870	broad.mit.edu	37	19	55748126	55748126	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:55748126C>A	uc002qjw.3	-	17	2115	c.1873G>T	c.(1873-1875)GAA>TAA	p.E625*	SAPS1_uc002qjv.2_Nonsense_Mutation_p.E687*	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	625	Glu-rich.|Poly-Glu.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		TCCTCCTCTTCCTCATCATCA	0.632			NA											17	50					1.02788e-11	1.50717e-11	0.00499	1	0
NLRP13	126204	broad.mit.edu	37	19	56424392	56424392	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:56424392T>A	uc010ygg.1	-	5	816	c.791A>T	c.(790-792)TAT>TTT	p.Y264F		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	264	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ATAGAAAACATAGGAGAACCT	0.463			NA											14	92					0	0	0.00245	0	0
ZNF583	147949	broad.mit.edu	37	19	56934258	56934258	+	Splice_Site	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:56934258A>T	uc010ygl.1	+	5	398	c.233_splice	c.e5-2	p.D78_splice	ZNF583_uc002qnc.2_Splice_Site_p.D78_splice|ZNF583_uc010ygm.1_Splice_Site_p.D78_splice	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		GATATCTTTTAGATTGGGAGT	0.284			NA											9	32					0	0	0.004482	0	0
USP29	57663	broad.mit.edu	37	19	57640595	57640595	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:57640595G>T	uc002qny.2	+	4	908	c.552G>T	c.(550-552)CTG>CTT	p.L184L		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	184					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGGACATTCTGAAGGAAGATA	0.358			NA											33	94					6.05902e-23	1.08447e-22	0.003755	1	0
ZNF606	80095	broad.mit.edu	37	19	58490843	58490843	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:58490843T>A	uc002qqw.2	-	7	1823	c.1205A>T	c.(1204-1206)TAC>TTC	p.Y402F	ZNF606_uc010yhp.1_Missense_Mutation_p.Y312F	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	402	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		ACATTCATTGTAGTCATAGGG	0.373			NA											49	53					0	0	0.00361	0	0
ZNF135	7694	broad.mit.edu	37	19	58572990	58572990	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:58572990G>T	uc010yhq.1	+	3	172	c.76G>T	c.(76-78)GAG>TAG	p.E26*	ZNF135_uc002qre.2_Nonsense_Mutation_p.E26*|ZNF135_uc002qrd.1_5'UTR|ZNF135_uc002qrf.2_5'UTR|ZNF135_uc002qrg.2_5'UTR|ZNF135_uc010yhr.1_Intron	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	26					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CTTCAGCCAGGAGGAGTGGGG	0.592			NA											34	51					1.45844e-13	2.2756e-13	0.002836	1	0
ZNF274	10782	broad.mit.edu	37	19	58724291	58724291	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:58724291C>T	uc002qrq.1	+	10	2203	c.1744C>T	c.(1744-1746)CTG>TTG	p.L582L	ZNF274_uc002qrr.1_Silent_p.L550L|ZNF274_uc002qrs.1_Silent_p.L477L|ZNF274_uc010eum.1_Silent_p.L341L	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	582	C2H2-type 3.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		CTCCCAGCACCTGAGGACTCA	0.542			NA											15	76					0	0	0.00245	0	0
A1BG	1	broad.mit.edu	37	19	58864391	58864391	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:58864391G>C	uc002qsd.3	-	3	305	c.243C>G	c.(241-243)TTC>TTG	p.F81L	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	81	Ig-like V-type 1.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CCGTCAGCAGGAACTGGTGCT	0.637			NA											11	63					0	0	0.001855	0	0
MYCN	4613	broad.mit.edu	37	2	16085778	16085778	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:16085778G>T	uc002rci.2	+	3	1254	c.954G>T	c.(952-954)CTG>CTT	p.L318L	MYCN_uc010yjr.1_Silent_p.L310L	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	318					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CCAGCGAGCTGATCCTCAAAC	0.592			NA	A		neuroblastoma								10	15					3.07112e-06	3.68823e-06	0.000978	1	0
VSNL1	7447	broad.mit.edu	37	2	17830709	17830709	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:17830709C>A	uc002rcm.2	+	3	579	c.195C>A	c.(193-195)GCC>GCA	p.A65A		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	65	EF-hand 2.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCAAGTTTGCCCAGCATGCCT	0.572			NA											25	91					7.26314e-15	1.1653e-14	0.007291	1	0
APOB	338	broad.mit.edu	37	2	21235326	21235326	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:21235326C>A	uc002red.2	-	26	4542	c.4414G>T	c.(4414-4416)GAC>TAC	p.D1472Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1472					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTTTGGAGTCCAAATGAACT	0.408			NA											44	50					2.62258e-09	3.54066e-09	0.002522	1	0
DNAJC27	51277	broad.mit.edu	37	2	25190085	25190085	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:25190085G>T	uc002rft.1	-	2	216	c.165C>A	c.(163-165)GTC>GTA	p.V55V	DNAJC27_uc010ykn.1_5'UTR|DNAJC27_uc002rfu.1_RNA|DNAJC27_uc010eyg.1_Silent_p.V55V	NM_016544	NP_057628	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	55					protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			skin(1)	1						CTTACTTTGTGACTCCATAGT	0.348			NA											23	33					9.86323e-18	1.67446e-17	0.003954	1	0
EHD3	30845	broad.mit.edu	37	2	31484546	31484546	+	Silent	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:31484546A>T	uc002rnu.2	+	5	1655	c.1047A>T	c.(1045-1047)TCA>TCT	p.S349S	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	349					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					ACCAGATCTCACCTGGGGACT	0.582			NA											21	85					0	0	0.00278	0	0
BIRC6	57448	broad.mit.edu	37	2	32613998	32613998	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:32613998C>T	uc010ezu.2	+	4	960	c.826C>T	c.(826-828)CGT>TGT	p.R276C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	276					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GGGGCCAGGCCGTTCTGTAGA	0.433	Pancreas(94;175 1509 16028 18060 45422)		NA											3	13					0	0	0.004672	0	0
LTBP1	4052	broad.mit.edu	37	2	33484662	33484662	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:33484662T>A	uc002ros.2	+	13	2403	c.2403T>A	c.(2401-2403)ACT>ACA	p.T801T	LTBP1_uc002rot.2_Silent_p.T475T|LTBP1_uc002rou.2_Silent_p.T475T|LTBP1_uc002rov.2_Silent_p.T422T|LTBP1_uc010ymz.1_Silent_p.T475T|LTBP1_uc010yna.1_Silent_p.T422T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	801					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAGTGGCAACTGCACCCCCTG	0.294			NA											35	97					0	0	0.00874	0	0
CRIM1	51232	broad.mit.edu	37	2	36669769	36669769	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:36669769G>T	uc002rpd.2	+	4	799	c.760G>T	c.(760-762)GAC>TAC	p.D254Y		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	254	Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TTTCGGCGTGGACTGCAGGAC	0.468			NA											53	80					2.5401e-28	4.65229e-28	0.00361	1	0
THADA	63892	broad.mit.edu	37	2	43797577	43797577	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:43797577C>A	uc002rsw.3	-	14	2489	c.2137G>T	c.(2137-2139)GAG>TAG	p.E713*	THADA_uc010far.2_5'UTR|THADA_uc002rsx.3_Nonsense_Mutation_p.E713*|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Nonsense_Mutation_p.E423*|THADA_uc010fat.1_5'UTR|THADA_uc002rta.2_Nonsense_Mutation_p.E423*|THADA_uc002rtb.1_Nonsense_Mutation_p.E713*|THADA_uc002rtc.3_Nonsense_Mutation_p.E713*|THADA_uc002rtd.2_Nonsense_Mutation_p.E713*	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	713							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AACTCATTCTCTGGTTCACGT	0.328			NA											27	33					1.42536e-11	2.08102e-11	0.004656	1	0
EPAS1	2034	broad.mit.edu	37	2	46574200	46574200	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:46574200C>T	uc002ruv.2	+	2	703	c.215C>T	c.(214-216)TCA>TTA	p.S72L		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	72					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CTCCTCTCCTCAGGTAAGGCC	0.587			NA											13	60					0	0	0.001855	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48809666	48809666	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:48809666G>T	uc010yol.1	+	1	1941	c.1894G>T	c.(1894-1896)GTA>TTA	p.V632L	STON1_uc002rwo.3_Missense_Mutation_p.V632L|STON1_uc010fbm.2_Missense_Mutation_p.V632L|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.V632L|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.V632L	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	632					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCAGGCAGTGGTATGGAAGAT	0.428			NA											9	39					0.000673444	0.000736895	0.008291	1	0
LHCGR	3973	broad.mit.edu	37	2	48915276	48915276	+	Nonsense_Mutation	SNP	G	G	A	rs121912524		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:48915276G>A	uc002rwu.3	-	11	1730	c.1660C>T	c.(1660-1662)CGA>TGA	p.R554*	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	554	Cytoplasmic (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity	p.R554*(1)		ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TCTGGGTTTCGAACTGCAAAA	0.368			NA							Familial_Male-Limited_Precocious_Puberty				19	98					0	0	0.006122	0	0
NRXN1	9378	broad.mit.edu	37	2	50733715	50733715	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:50733715A>T	uc010fbq.2	-	13	4012	c.2535T>A	c.(2533-2535)AAT>AAA	p.N845K	NRXN1_uc002rxb.3_Missense_Mutation_p.N477K|NRXN1_uc002rxe.3_Missense_Mutation_p.N805K|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	173	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTCGTTATCATTGAGGTTAT	0.453			NA											19	19					0	0	0.008871	0	0
NRXN1	9378	broad.mit.edu	37	2	51254933	51254934	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:51254933_51254934GG>AT	uc010fbq.2	-	2	1955_1956	c.478_479CC>AT	c.(478-480)CCG>ATG	p.P160M	NRXN1_uc002rxe.3_Missense_Mutation_p.P160M|NRXN1_uc002rxd.1_Missense_Mutation_p.P160M	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCGCAGTTCCGGGGGCAGCCCC	0.663			NA											8	7					0	0	0.004672	0	0
SPTBN1	6711	broad.mit.edu	37	2	54872432	54872432	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:54872432C>T	uc002rxu.2	+	21	4585	c.4336C>T	c.(4336-4338)CTG>TTG	p.L1446L	SPTBN1_uc002rxx.2_Silent_p.L1433L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1446	Spectrin 11.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGCCCAGGCCCTGAGTCAGGA	0.577			NA											18	73					0	0	0.00499	0	0
AAK1	22848	broad.mit.edu	37	2	69736519	69736519	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:69736519C>A	uc002sfp.2	-	14	2355	c.1850G>T	c.(1849-1851)GGA>GTA	p.G617V	AAK1_uc010fdk.2_Missense_Mutation_p.G617V|AAK1_uc010yqm.1_Missense_Mutation_p.G618V	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	617						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						AGTGAGAGATCCAACTTTCTG	0.557			NA											14	28					7.93312e-07	9.7214e-07	0.00245	1	0
GMCL1	64395	broad.mit.edu	37	2	70096905	70096905	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:70096905A>G	uc002sfu.2	+	12	1480	c.1273A>G	c.(1273-1275)ACC>GCC	p.T425A		NM_178439	NP_848526	Q96IK5	GMCL1_HUMAN	germ cell-less	425					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				ovary(3)	3						TGTAACTTACACCAATCGATA	0.398			NA											42	75					0	0	0.003214	0	0
VAX2	25806	broad.mit.edu	37	2	71148364	71148364	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:71148364G>T	uc002shh.2	+	2	416	c.384G>T	c.(382-384)GTG>GTT	p.V128V		NM_012476	NP_036608	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	128	Homeobox.				ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGTATGTGGTGGGCCGCGAGC	0.657			NA											14	52					4.14922e-12	6.17249e-12	0.004007	1	0
ALMS1	7840	broad.mit.edu	37	2	73678725	73678725	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:73678725G>T	uc002sje.1	+	10	5185	c.5074G>T	c.(5074-5076)GTT>TTT	p.V1692F	ALMS1_uc002sjf.1_Missense_Mutation_p.V1648F|ALMS1_uc002sjg.2_Missense_Mutation_p.V1078F|ALMS1_uc002sjh.1_Missense_Mutation_p.V1078F	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1690	25.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AGCTCTGAAAGTTCCACCTGT	0.438			NA											18	114					1.33834e-09	1.81403e-09	0.007413	1	0
C2orf89	129293	broad.mit.edu	37	2	85049050	85049050	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:85049050G>T	uc010ysl.1	-	7	1598	c.1509C>A	c.(1507-1509)CCC>CCA	p.P503P	C2orf89_uc002sou.3_Silent_p.P454P	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	503	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						GTTACAGGAGGGGTGTCTCTG	0.572			NA											4	7					0.00909568	0.00956356	0.009096	1	0
SFTPB	6439	broad.mit.edu	37	2	85894864	85894864	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:85894864G>A	uc002sqh.2	-	2	139	c.133C>T	c.(133-135)CAA>TAA	p.Q45*	SFTPB_uc002sqi.2_Nonsense_Mutation_p.Q57*|SFTPB_uc002sqj.2_Nonsense_Mutation_p.Q45*	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	45	Saposin A-type.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						TGCAATGCTTGCTCCAGGCTT	0.592			NA											44	65					0	0	0.003214	0	0
CIAO1	9391	broad.mit.edu	37	2	96936996	96936996	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:96936996G>T	uc002svs.2	+	7	1132	c.927G>T	c.(925-927)GTG>GTT	p.V309V		NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	309	WD 7.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						TCAACTGTGTGGCCTGGAACC	0.602			NA											25	45					3.28513e-13	5.05632e-13	0.003954	1	0
SNRNP200	23020	broad.mit.edu	37	2	96950178	96950178	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:96950178C>A	uc002svu.2	-	31	4396	c.4310G>T	c.(4309-4311)CGG>CTG	p.R1437L	SNRNP200_uc002svt.2_Missense_Mutation_p.R47L|SNRNP200_uc010yuj.1_RNA|SNRNP200_uc002svv.1_5'UTR	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1437	Helicase ATP-binding 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CTTCCATCGCCGGGAAAGTAT	0.557			NA											27	43					4.7796e-09	6.37696e-09	0.004656	1	0
VWA3B	200403	broad.mit.edu	37	2	98736075	98736075	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:98736075C>T	uc002syo.2	+	4	655	c.391C>T	c.(391-393)CGG>TGG	p.R131W	VWA3B_uc010yvh.1_Intron|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Missense_Mutation_p.R131W|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	131										ovary(3)|large_intestine(2)|skin(1)	6						CAGCAAGAGCCGGCAGATTTT	0.498			NA											17	163					0	0	0.00499	0	0
MGAT4A	11320	broad.mit.edu	37	2	99242232	99242232	+	Missense_Mutation	SNP	C	C	A	rs146487281		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:99242232C>A	uc002sze.2	-	15	1849	c.1535G>T	c.(1534-1536)CGA>CTA	p.R512L	C2orf64_uc002sza.2_Intron|MGAT4A_uc010yvm.1_Missense_Mutation_p.R384L|MGAT4A_uc010fil.2_Missense_Mutation_p.R266L	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	512	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						AACTGAAAGTCGAAAGGCTGA	0.338			NA											8	39					3.09899e-07	3.85769e-07	0.004482	1	0
CREG2	200407	broad.mit.edu	37	2	101967402	101967402	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:101967402C>A	uc002tba.2	-	4	902	c.856G>T	c.(856-858)GTT>TTT	p.V286F		NM_153836	NP_722578	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	286						extracellular region	FMN binding			ovary(1)	1						TTTCTGGGAACTGCTTTGAAA	0.418			NA											36	135					7.63091e-17	1.2764e-16	0.007835	1	0
SLC9A4	389015	broad.mit.edu	37	2	103090302	103090302	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:103090302T>A	uc002tbz.3	+	1	541	c.84T>A	c.(82-84)TCT>TCA	p.S28S		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	28					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						AAGCATCTTCTGATTTGAATG	0.463			NA											46	152					0	0	0.00361	0	0
GCC2	9648	broad.mit.edu	37	2	109067569	109067569	+	Splice_Site	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:109067569G>C	uc002tec.2	+	3	302	c.148_splice	c.e3+1	p.E50_splice	GCC2_uc002ted.2_Intron	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2						Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AGGTGTACAGGTATTGGGTTG	0.358			NA											10	33					0	0	0.006214	0	0
RANBP2	5903	broad.mit.edu	37	2	109380142	109380142	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:109380142A>G	uc002tem.3	+	20	3273	c.3147A>G	c.(3145-3147)CCA>CCG	p.P1049P		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1049					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TTTCCTCACCACAGGTTGTGA	0.443			NA											17	128					0	0	0.008871	0	0
CCDC138	165055	broad.mit.edu	37	2	109408185	109408185	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:109408185A>G	uc002ten.1	+	4	381	c.321A>G	c.(319-321)GAA>GAG	p.E107E	CCDC138_uc002teo.1_Silent_p.E107E|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	107											0						AAACAGAAGAAGAGTTAATTG	0.274			NA											22	79					0	0	0.00333	0	0
CCDC138	165055	broad.mit.edu	37	2	109415040	109415040	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:109415040G>T	uc002ten.1	+	6	793	c.733G>T	c.(733-735)GAG>TAG	p.E245*	CCDC138_uc002teo.1_Nonsense_Mutation_p.E245*|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	245	Potential.										0						AATTATAAAAGAGGTAACTAT	0.294			NA											15	49					6.31663e-08	8.08971e-08	0.003163	1	0
CCDC93	54520	broad.mit.edu	37	2	118753904	118753904	+	Missense_Mutation	SNP	T	T	A	rs113727191		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:118753904T>A	uc002tlj.2	-	5	524	c.398A>T	c.(397-399)GAG>GTG	p.E133V	CCDC93_uc010fld.1_Missense_Mutation_p.E133V	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	133										large_intestine(1)|ovary(1)	2						GTCACCCATCTCTTCTTTTGT	0.448			NA											14	38					0	0	0.004007	0	0
TFCP2L1	29842	broad.mit.edu	37	2	122004483	122004483	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:122004483G>A	uc002tmx.2	-	6	661	c.568C>T	c.(568-570)CGA>TGA	p.R190*	TFCP2L1_uc010flr.2_Nonsense_Mutation_p.R190*	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	190					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					ATCTGGACTCGAAAGGGCACT	0.567			NA											14	47					0	0	0.001855	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125261947	125261947	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:125261947C>A	uc002tno.2	+	8	1502	c.1138C>A	c.(1138-1140)CTG>ATG	p.L380M	CNTNAP5_uc010flu.2_Missense_Mutation_p.L381M	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	380	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTATTTGCTGCTGCCCGGCAC	0.502			NA											24	39					1.04121e-07	1.32189e-07	0.005443	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125281974	125281974	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:125281974G>A	uc002tno.2	+	9	1783	c.1419G>A	c.(1417-1419)CCG>CCA	p.P473P	CNTNAP5_uc010flu.2_Silent_p.P474P	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	473	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CAGCACCCCCGGCTCCAGACA	0.493			NA											11	17					0	0	0.008291	0	0
MAP3K2	10746	broad.mit.edu	37	2	128075837	128075837	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:128075837C>G	uc002toj.1	-	12	1167	c.1102G>C	c.(1102-1104)GGA>CGA	p.G368R		NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	368	Protein kinase.|ATP (By similarity).				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		TAGACCCTTCCAAAGGCTCCT	0.443			NA											7	50					0	0	0.001984	0	0
MYO7B	4648	broad.mit.edu	37	2	128367543	128367543	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:128367543G>T	uc002top.2	+	24	3197	c.3144G>T	c.(3142-3144)CTG>CTT	p.L1048L		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1048	MyTH4 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ATGACACGCTGGGCAGGGAGC	0.627			NA											7	9					1.06961e-07	1.35626e-07	0.00308	1	0
MCM6	4175	broad.mit.edu	37	2	136623838	136623838	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:136623838G>C	uc002tuw.2	-	6	867	c.791C>G	c.(790-792)GCA>GGA	p.A264G		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	264					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	ATTAGTTTCTGCACGTGCTCC	0.413	Ovarian(196;141 2104 8848 24991 25939)		NA											5	192					0	0	0.001984	0	0
LRP1B	53353	broad.mit.edu	37	2	141291702	141291702	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:141291702T>A	uc002tvj.1	-	47	8622	c.7650A>T	c.(7648-7650)AGA>AGT	p.R2550S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2550	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCGACAGCTTCTGTTTTCTT	0.353	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			9	22					0	0	0.008291	0	0
ZEB2	9839	broad.mit.edu	37	2	145187456	145187456	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:145187456A>G	uc002tvu.2	-	3	691	c.211T>C	c.(211-213)TCC>CCC	p.S71P	ZEB2_uc002tvv.2_Missense_Mutation_p.S66P|ZEB2_uc010zbm.1_Missense_Mutation_p.S66P|ZEB2_uc010fnp.2_Missense_Mutation_p.S66P|ZEB2_uc010fnq.1_Missense_Mutation_p.S100P|ZEB2_uc002tvw.2_Missense_Mutation_p.S66P	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	71						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		ACGTGTGGGGAGGACTCATGG	0.522	Melanoma(33;1235 1264 5755 16332)		NA											15	60					0	0	0.004007	0	0
NEB	4703	broad.mit.edu	37	2	152432208	152432208	+	Splice_Site	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:152432208C>T	uc010fnx.2	-	79	12101	c.11910_splice	c.e79+1	p.N3970_splice	NEB_uc002txr.2_Splice_Site_p.N393_splice	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTAGTACTTACATTGCTCACA	0.423			NA											64	155					0	0	0.00361	0	0
GPD2	2820	broad.mit.edu	37	2	157426037	157426037	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:157426037G>C	uc002tzf.3	+	11	1823	c.1463G>C	c.(1462-1464)GGA>GCA	p.G488A	GPD2_uc010zch.1_Missense_Mutation_p.G261A|GPD2_uc002tzd.3_Missense_Mutation_p.G488A|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	488					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						CAGGATTATGGACTTGAAAGC	0.468			NA											12	69					0	0	0.001368	0	0
GALNT5	11227	broad.mit.edu	37	2	158142619	158142619	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:158142619A>T	uc002tzg.2	+	3	1969	c.1714A>T	c.(1714-1716)AGG>TGG	p.R572W	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	572	Catalytic subdomain A.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						AATAAGGGCCAGGCTGGCAGG	0.308			NA											10	31					0	0	0.001368	0	0
BAZ2B	29994	broad.mit.edu	37	2	160194283	160194283	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:160194283C>A	uc002uao.2	-	32	5807	c.5455G>T	c.(5455-5457)GGT>TGT	p.G1819C	BAZ2B_uc002uap.2_Missense_Mutation_p.G1783C	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1819					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CACATCCAACCCTATATATCA	0.368			NA											16	52					0.000422831	0.000465661	0.004007	1	0
DPP4	1803	broad.mit.edu	37	2	162895493	162895493	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:162895493T>A	uc002ubz.2	-	7	1019	c.458A>T	c.(457-459)CAG>CTG	p.Q153L	DPP4_uc010fpb.2_5'UTR|DPP4_uc002uca.1_RNA|DPP4_uc002ucb.1_RNA	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	153	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	TGTGACCCACTGTGTGTTGTT	0.373			NA											25	53					0	0	0.008361	0	0
SCN1A	6323	broad.mit.edu	37	2	166901690	166901690	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:166901690G>A	uc010zcz.1	-	10	1543	c.1525C>T	c.(1525-1527)CAG>TAG	p.Q509*	SCN1A_uc002udo.3_Nonsense_Mutation_p.Q378*|SCN1A_uc010fpk.2_Nonsense_Mutation_p.Q378*	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	509						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCACCAGACTGCTCTTTCTGT	0.458			NA											59	240					0	0	0.00361	0	0
SCN9A	6335	broad.mit.edu	37	2	167060953	167060953	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:167060953T>A	uc010fpl.2	-	25	4728	c.4387A>T	c.(4387-4389)ATG>TTG	p.M1463L	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1474						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTTCTGTCATAAAGATGTCT	0.323			NA											6	31					0	0	0.001168	0	0
SCN9A	6335	broad.mit.edu	37	2	167168061	167168061	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:167168061C>A	uc010fpl.2	-	2	547	c.206G>T	c.(205-207)GGC>GTC	p.G69V		NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	69						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGACACCATGCCGGGAGGAAT	0.483			NA											27	57					1.17739e-12	1.79062e-12	0.005443	1	0
XIRP2	129446	broad.mit.edu	37	2	168107344	168107344	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:168107344G>A	uc002udx.2	+	8	9460	c.9442G>A	c.(9442-9444)GAC>AAC	p.D3148N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D2973N|XIRP2_uc010fpq.2_Missense_Mutation_p.D2926N|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2973					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CCCTAAAAAGGACAGTTATGT	0.468			NA											23	66					0	0	0.00333	0	0
LRP2	4036	broad.mit.edu	37	2	170042416	170042416	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:170042416G>T	uc002ues.2	-	50	9655	c.9442C>A	c.(9442-9444)CGG>AGG	p.R3148R		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3148	EGF-like 11.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACAAGTCCGCTTGTCAGAC	0.468			NA											37	72					2.05212e-20	3.57895e-20	0.005524	1	0
DLX1	1745	broad.mit.edu	37	2	172952919	172952919	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:172952919C>A	uc002uhl.2	+	3	900	c.702C>A	c.(700-702)ATC>ATA	p.I234I	DLX1_uc002uhm.2_3'UTR	NM_178120	NP_835221	P56177	DLX1_HUMAN	distal-less homeobox 1 isoform 1	234						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GCTCCTATATCCCCAGCTACA	0.627			NA											29	76					4.15321e-07	5.16372e-07	0.009535	1	0
TTN	7273	broad.mit.edu	37	2	179408023	179408023	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179408023G>T	uc010zfg.1	-	296	89197	c.88973C>A	c.(88972-88974)CCA>CAA	p.P29658Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P23353Q|TTN_uc010zfi.1_Missense_Mutation_p.P23286Q|TTN_uc010zfj.1_Missense_Mutation_p.P23161Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30585							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCGTAGAGTGGTTTTTCCCA	0.502			NA											16	100					4.7546e-09	6.3519e-09	0.004007	1	0
TTN	7273	broad.mit.edu	37	2	179413591	179413591	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179413591G>C	uc010zfg.1	-	288	85282	c.85058C>G	c.(85057-85059)ACA>AGA	p.T28353R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T22048R|TTN_uc010zfi.1_Missense_Mutation_p.T21981R|TTN_uc010zfj.1_Missense_Mutation_p.T21856R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCAGGAGCTGTTAACCGGTC	0.458			NA											15	59					0	0	0.003163	0	0
TTN	7273	broad.mit.edu	37	2	179432942	179432942	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179432942G>T	uc010zfg.1	-	275	70437	c.70213C>A	c.(70213-70215)CAA>AAA	p.Q23405K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Q17100K|TTN_uc010zfi.1_Missense_Mutation_p.Q17033K|TTN_uc010zfj.1_Missense_Mutation_p.Q16908K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24332							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAAAGCTTTGTCCATATCTG	0.413			NA											45	126					4.0181e-32	7.53486e-32	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179434396	179434396	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179434396C>A	uc010zfg.1	-	275	68983	c.68759G>T	c.(68758-68760)GGA>GTA	p.G22920V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16615V|TTN_uc010zfi.1_Missense_Mutation_p.G16548V|TTN_uc010zfj.1_Missense_Mutation_p.G16423V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23847							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTCCAACTCCAGCTTTATT	0.368			NA											8	26					5.4927e-09	7.29032e-09	0.004482	1	0
TTN	7273	broad.mit.edu	37	2	179529215	179529216	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179529215_179529216GG>TT	uc010zfk.1	-	13	1237_1238	c.689_690CC>AA	c.(688-690)CCC>CAA	p.P230Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCCCTTTGGGGAGGATGCAC	0.411			NA											41	107					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179594234	179594234	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179594234C>A	uc010zfg.1	-	61	15141	c.14917G>T	c.(14917-14919)GAG>TAG	p.E4973*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.E1634*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5900							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTCCAGCTCCACGTCACTA	0.448			NA											30	69					2.65835e-16	4.39616e-16	0.007291	1	0
TTN	7273	broad.mit.edu	37	2	179610535	179610535	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179610535G>T	uc002unb.2	-	46	16816	c.16592C>A	c.(16591-16593)GCA>GAA	p.A5531E	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAAAATATGCTGCTGTACC	0.428			NA											17	88					4.7546e-09	6.3519e-09	0.004007	1	0
TTN	7273	broad.mit.edu	37	2	179614934	179614934	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:179614934G>T	uc002unb.2	-	46	12417	c.12193C>A	c.(12193-12195)CAA>AAA	p.Q4065K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTTTGCTTGGTCAAACACC	0.413			NA											23	53					1.64293e-13	2.55567e-13	0.00333	1	0
ITGA4	3676	broad.mit.edu	37	2	182344887	182344887	+	Silent	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:182344887A>T	uc002unu.2	+	6	1411	c.648A>T	c.(646-648)CCA>CCT	p.P216P	ITGA4_uc010zfl.1_Silent_p.P216P	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	216	FG-GAP 3.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGGGGGCCCCAGGATCATCTT	0.333			NA											13	29					0	0	0.00245	0	0
DNAJC10	54431	broad.mit.edu	37	2	183586760	183586760	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:183586760G>A	uc002uow.1	+	5	791	c.376G>A	c.(376-378)GAT>AAT	p.D126N	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.D126N|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	126					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			aGGTATTTATGATGATGATCC	0.219	Pancreas(56;860 1183 25669 35822 48585)		NA											11	52					0	0	0.008291	0	0
ZC3H15	55854	broad.mit.edu	37	2	187371499	187371499	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:187371499A>G	uc002upo.2	+	9	1251	c.1026A>G	c.(1024-1026)GTA>GTG	p.V342V		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	342				V -> A (in Ref. 2; AAF28981).		cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			CAAGAGATGTAGATGAAACAG	0.318			NA											41	71					0	0	0.007835	0	0
DIRC1	116093	broad.mit.edu	37	2	189599535	189599535	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:189599535G>C	uc002uqi.1	-	2	384	c.113C>G	c.(112-114)CCC>CGC	p.P38R		NM_052952	NP_443184	Q969H9	DIRC1_HUMAN	disrupted in renal carcinoma 1	38											0			OV - Ovarian serous cystadenocarcinoma(117;0.00842)|Epithelial(96;0.102)			TATACACATGGGGTGGGCATT	0.473			NA											26	96					0	0	0.00632	0	0
COL3A1	1281	broad.mit.edu	37	2	189868867	189868867	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:189868867C>A	uc002uqj.1	+	39	2938	c.2821C>A	c.(2821-2823)CCA>ACA	p.P941T		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	941	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCAGGGCCCACCAGTAAGTAA	0.448			NA											9	27					1.76689e-08	2.29449e-08	0.006214	1	0
COL5A2	1290	broad.mit.edu	37	2	189917528	189917528	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:189917528C>G	uc002uqk.2	-	40	2937	c.2662G>C	c.(2662-2664)GGT>CGT	p.G888R	COL5A2_uc010frx.2_Missense_Mutation_p.G464R	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	888					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCATTAGGACCCTGAATAGAA	0.423			NA											7	46					0	0	0.00308	0	0
STK17B	9262	broad.mit.edu	37	2	197002295	197002295	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:197002295C>T	uc002utk.2	-	8	1319	c.995G>A	c.(994-996)GGA>GAA	p.G332E	STK17B_uc010fsh.2_Missense_Mutation_p.G332E	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	332					apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)			ACCACAGGTTCCATTACAGGA	0.418			NA											32	78					0	0	0.002096	0	0
ANKRD44	91526	broad.mit.edu	37	2	197943539	197943540	+	Splice_Site	DNP	CT	CT	TG			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:197943539_197943540CT>TG	uc002uua.1	-	16	1541	c.1464_splice	c.e16-1	p.L488_splice	ANKRD44_uc002utz.3_Splice_Site_p.L220_splice|ANKRD44_uc002uub.2_Intron|ANKRD44_uc010zgw.1_Intron	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44								protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTCTAGACATCTGTAAGTATAA	0.371			NA											8	21					0	0	0.004672	0	0
PLCL1	5334	broad.mit.edu	37	2	198950287	198950287	+	Silent	SNP	G	G	T	rs144487956	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:198950287G>T	uc010fsp.2	+	2	2337	c.2046G>T	c.(2044-2046)ACG>ACT	p.T682T	PLCL1_uc002uuv.3_Silent_p.T603T	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	682	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	ACCTTCACACGGGCTGGTTTC	0.443			NA											13	96					1.36491e-13	2.13293e-13	0.001855	1	0
MAP2	4133	broad.mit.edu	37	2	210574774	210574774	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:210574774C>T	uc002vde.1	+	12	5117	c.4869C>T	c.(4867-4869)CCC>CCT	p.P1623P	MAP2_uc002vdd.1_Silent_p.P324P|MAP2_uc002vdf.1_Silent_p.P267P|MAP2_uc002vdg.1_Silent_p.P267P|MAP2_uc002vdh.1_Silent_p.P324P|MAP2_uc002vdi.1_Silent_p.P1619P	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1623					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTAGCTATCCCAGGACCCCTC	0.572	Pancreas(27;423 979 28787 29963)		NA											3	74					0	0	0.004672	0	0
ERBB4	2066	broad.mit.edu	37	2	212248511	212248511	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:212248511G>A	uc002veg.1	-	28	3854	c.3756C>T	c.(3754-3756)ACC>ACT	p.T1252T	ERBB4_uc002veh.1_Silent_p.T1236T|ERBB4_uc010zji.1_Silent_p.T1242T|ERBB4_uc010zjj.1_Silent_p.T1226T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1252	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GGTGCTGAAGGGTGCTCCGAG	0.493			NA								TSP Lung(8;0.080)			21	63					0	0	0.00333	0	0
ERBB4	2066	broad.mit.edu	37	2	212530091	212530091	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:212530091G>T	uc002veg.1	-	15	1926	c.1828C>A	c.(1828-1830)CCA>ACA	p.P610T	ERBB4_uc002veh.1_Missense_Mutation_p.P610T|ERBB4_uc010zji.1_Missense_Mutation_p.P610T|ERBB4_uc010zjj.1_Missense_Mutation_p.P610T|ERBB4_uc010fut.1_Missense_Mutation_p.P610T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	610	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCCGATCTGGATCAGCATAC	0.468			NA								TSP Lung(8;0.080)			20	65					1.96292e-10	2.75943e-10	0.010504	1	0
IKZF2	22807	broad.mit.edu	37	2	213914437	213914437	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:213914437C>A	uc002vem.2	-	5	743	c.574G>T	c.(574-576)GTG>TTG	p.V192L	IKZF2_uc010fuu.2_Intron|IKZF2_uc002vej.2_Missense_Mutation_p.V139L|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.V166L|IKZF2_uc002vel.2_Missense_Mutation_p.V113L|IKZF2_uc010fuw.2_5'UTR|IKZF2_uc010fux.2_5'UTR|IKZF2_uc010fuy.2_Missense_Mutation_p.V166L|IKZF2_uc002ven.2_Missense_Mutation_p.V166L	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TGACACTTACCAGAATGGGTC	0.428			NA											22	58					4.26978e-12	6.3426e-12	0.00333	1	0
PNKD	25953	broad.mit.edu	37	2	219204767	219204767	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:219204767C>G	uc002vhn.2	+	4	512	c.368C>G	c.(367-369)CCC>CGC	p.P123R	PNKD_uc002vhq.2_Missense_Mutation_p.P99R	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	123						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGGTGCTTCCCATCCCTGTC	0.647			NA											19	40					0	0	0.008871	0	0
ANKZF1	55139	broad.mit.edu	37	2	220098546	220098546	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:220098546A>C	uc002vkg.2	+	8	1103	c.929A>C	c.(928-930)AAG>ACG	p.K310T	ANKZF1_uc010zkv.1_Missense_Mutation_p.K254T|ANKZF1_uc010zkw.1_Missense_Mutation_p.K100T|ANKZF1_uc002vkh.2_Missense_Mutation_p.K100T|ANKZF1_uc002vki.2_Missense_Mutation_p.K310T|ANKZF1_uc002vkj.1_Missense_Mutation_p.K298T	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	310						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTTGGAGGCAAGGGAGCACCC	0.622			NA											16	54					0	0	0.006122	0	0
KIAA1486	57624	broad.mit.edu	37	2	226446931	226446931	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:226446931C>T	uc002voe.2	+	4	973	c.798C>T	c.(796-798)GCC>GCT	p.A266A	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Silent_p.A36A	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	266										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		AGAGCGAGGCCGTCTACGAGG	0.562			NA											41	87					0	0	0.00623	0	0
COL4A3	1285	broad.mit.edu	37	2	228119376	228119376	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:228119376T>A	uc002vom.1	+	15	995	c.833T>A	c.(832-834)CTG>CAG	p.L278Q	COL4A3_uc002von.1_Missense_Mutation_p.L278Q|COL4A3_uc002voo.1_Missense_Mutation_p.L278Q|COL4A3_uc002vop.1_Missense_Mutation_p.L278Q|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	278	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		ATACAGGGACTGCCTGGAGAA	0.353			NA											28	70					0	0	0.007291	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882763	228882763	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:228882763G>C	uc002vpq.2	-	7	2854	c.2807C>G	c.(2806-2808)ACG>AGG	p.T936R	SPHKAP_uc002vpp.2_Missense_Mutation_p.T936R|SPHKAP_uc010zlx.1_Missense_Mutation_p.T936R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	936	PKA-RII subunit binding domain (By similarity).					cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGAGACGACCGTGTCTGCTAA	0.473			NA											21	124					0	0	0.010504	0	0
COL6A3	1293	broad.mit.edu	37	2	238287867	238287867	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:238287867T>C	uc002vwl.2	-	6	2194	c.1909A>G	c.(1909-1911)AAA>GAA	p.K637E	COL6A3_uc002vwo.2_Missense_Mutation_p.K431E|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Missense_Mutation_p.K431E|COL6A3_uc002vwr.2_Missense_Mutation_p.K230E|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	637	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATATCCCTTTTGTTTGAGTGA	0.418			NA											7	57					0	0	0.00308	0	0
OR6B3	150681	broad.mit.edu	37	2	240985276	240985276	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:240985276A>T	uc010zoe.1	-	1	214	c.214T>A	c.(214-216)TGG>AGG	p.W72R	PRR21_uc010zod.1_5'Flank	NM_173351	NP_775486	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		GACACGTACCAGATCTCTAGG	0.557			NA											20	66					0	0	0.00278	0	0
AQP12B	653437	broad.mit.edu	37	2	241622087	241622087	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:241622087C>G	uc010fzj.2	-	1	231	c.168G>C	c.(166-168)ACG>ACC	p.T56T	AQP12B_uc002vzt.2_Intron	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B	44						integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GCTCGACCAGCGTCCTCATCT	0.701			NA											6	43					0	0	0.001168	0	0
SIRPG	55423	broad.mit.edu	37	20	1629708	1629708	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:1629708C>A	uc002wfm.1	-	2	485	c.420G>T	c.(418-420)ATG>ATT	p.M140I	SIRPG_uc002wfn.1_Missense_Mutation_p.M140I|SIRPG_uc002wfo.1_Missense_Mutation_p.M140I	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	140	Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						CACCCAAAGCCATCTCAGTGC	0.488			NA											23	85					3.28513e-13	5.05632e-13	0.003954	1	0
FASTKD5	60493	broad.mit.edu	37	20	3127960	3127960	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:3127960C>A	uc002whz.2	-	2	2068	c.1757G>T	c.(1756-1758)CGA>CTA	p.R586L	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	586					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						GTCAGAAGATCGGGTATGAGG	0.448			NA											35	86					4.65686e-17	7.80216e-17	0.003755	1	0
FASTKD5	60493	broad.mit.edu	37	20	3129681	3129681	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:3129681T>C	uc002whz.2	-	2	347	c.36A>G	c.(34-36)AGA>AGG	p.R12R	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	12					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						ATGCTCGGTATCTTACAAGTT	0.473			NA											32	38					0	0	0.002445	0	0
ADRA1D	146	broad.mit.edu	37	20	4202212	4202212	+	Nonsense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:4202212G>C	uc002wkr.2	-	2	1732	c.1677C>G	c.(1675-1677)TAC>TAG	p.Y559*		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	559	Cytoplasmic (By similarity).			KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRA EAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRET DI -> SHPAPSASGGCWGRSGDPRPSCAPKSPACRTRSPP GARSAQRQRAPSAQRWRLCP (in Ref. 1).	cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	CGGCCAATTCGTAGGCCTGGC	0.667			NA											6	31					0	0	0.001168	0	0
SEL1L2	80343	broad.mit.edu	37	20	13858199	13858199	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:13858199G>T	uc010gcf.2	-	11	1075	c.993C>A	c.(991-993)GCC>GCA	p.A331A	SEL1L2_uc002woq.3_Silent_p.A192A|SEL1L2_uc010zrl.1_Silent_p.A331A|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	331	Extracellular (Potential).|Sel1-like 5.					integral to membrane	binding			ovary(2)	2						TTGCACTCCCGGCCTTTGCTG	0.318			NA											11	52					1.05317e-09	1.43896e-09	0.00245	1	0
SNX5	27131	broad.mit.edu	37	20	17932182	17932182	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:17932182C>A	uc002wqc.2	-	6	657	c.571G>T	c.(571-573)GTG>TTG	p.V191L	SNX5_uc002wqb.2_RNA|SNX5_uc002wqd.2_Missense_Mutation_p.V191L|SNX5_uc002wqe.2_Missense_Mutation_p.V86L|SNX5_uc010zrt.1_Missense_Mutation_p.V191L	NM_014426	NP_055241	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	191					cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			large_intestine(1)	1						GCACTTTTCACCACACTTTTG	0.358			NA											33	75					4.14481e-20	7.21634e-20	0.00623	1	0
ZNF133	7692	broad.mit.edu	37	20	18297168	18297168	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:18297168G>T	uc010gcq.2	+	5	1978	c.1673G>T	c.(1672-1674)GGC>GTC	p.G558V	ZNF133_uc010zrv.1_Missense_Mutation_p.G561V|ZNF133_uc010zrw.1_Missense_Mutation_p.G495V|ZNF133_uc010gcr.2_Missense_Mutation_p.G558V|ZNF133_uc010zrx.1_Missense_Mutation_p.G463V|ZNF133_uc002wql.3_Missense_Mutation_p.G557V|ZNF133_uc010gcs.2_Missense_Mutation_p.G557V|ZNF133_uc010zry.1_Missense_Mutation_p.G463V|ZNF133_uc002wqm.2_Missense_Mutation_p.G558V	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	558	C2H2-type 13.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						TGTGGACTGGGCTTTGGCAAT	0.562			NA											11	29					2.80697e-09	3.77464e-09	0.000978	1	0
RALGAPA2	57186	broad.mit.edu	37	20	20582347	20582347	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:20582347T>C	uc002wrz.2	-	16	2325	c.2182A>G	c.(2182-2184)ATT>GTT	p.I728V	RALGAPA2_uc010gcx.2_Missense_Mutation_p.I432V|RALGAPA2_uc010zsg.1_Missense_Mutation_p.I129V	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	728					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGGCGAACAATATTTCTTGCC	0.398			NA											3	50					0	0	0.004672	0	0
BPIL3	128859	broad.mit.edu	37	20	31627309	31627309	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:31627309C>T	uc010zuc.1	+	10	1057	c.1057C>T	c.(1057-1059)CTC>TTC	p.L353F	BPIL3_uc010zud.1_Missense_Mutation_p.L292F	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	353						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						TCCAATGTCCCTCTTTCTCCT	0.537			NA											72	98					0	0	0.00361	0	0
DLGAP4	22839	broad.mit.edu	37	20	35128633	35128633	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:35128633C>T	uc002xff.2	+	10	2557	c.2122C>T	c.(2122-2124)CGA>TGA	p.R708*	DLGAP4_uc010zvp.1_Nonsense_Mutation_p.R708*|DLGAP4_uc002xfg.2_Nonsense_Mutation_p.R4*|DLGAP4_uc002xfh.2_Nonsense_Mutation_p.R172*|DLGAP4_uc002xfi.2_Nonsense_Mutation_p.R17*|DLGAP4_uc002xfj.2_Nonsense_Mutation_p.R4*	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	711					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				TATGTCCTCCCGACGGGACAC	0.597			NA											14	21					0	0	0.004007	0	0
DSN1	79980	broad.mit.edu	37	20	35390863	35390863	+	Splice_Site	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:35390863C>T	uc010gfr.2	-	6	963	c.590_splice	c.e6+1	p.G197_splice	DSN1_uc002xfz.2_Splice_Site_p.G197_splice|DSN1_uc002xfy.3_Splice_Site|DSN1_uc002xga.2_Splice_Site_p.G197_splice|DSN1_uc010zvs.1_Splice_Site_p.G90_splice|DSN1_uc002xgc.2_Splice_Site_p.G181_splice|DSN1_uc002xgb.2_Splice_Site_p.G181_splice	NM_001145316	NP_001138788	Q9H410	DSN1_HUMAN	DSN1, MIND kinetochore complex component,						cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)				ACTGCTCTTACCCATTTGAAT	0.274			NA											12	16					0	0	0.00245	0	0
JPH2	57158	broad.mit.edu	37	20	42788285	42788285	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:42788285C>A	uc002xli.1	-	2	2015	c.1142G>T	c.(1141-1143)CGC>CTC	p.R381L		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	381	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGCCTTCTGGCGCGCGATAGC	0.672			NA											7	9					0.000157383	0.000175596	0.00308	1	0
HNF4A	3172	broad.mit.edu	37	20	43034844	43034844	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:43034844G>T	uc002xma.2	+	2	351	c.262G>T	c.(262-264)GTG>TTG	p.V88L	HNF4A_uc010zwo.1_Silent_p.A78A|HNF4A_uc002xlt.2_Missense_Mutation_p.V66L|HNF4A_uc002xlu.2_Missense_Mutation_p.V66L|HNF4A_uc002xlv.2_Missense_Mutation_p.V66L|HNF4A_uc002xly.2_Missense_Mutation_p.V88L|HNF4A_uc002xlz.2_Missense_Mutation_p.V88L|HNF4A_uc010ggq.2_Missense_Mutation_p.V81L	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	88	Nuclear receptor.				blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCGGAGGAGCGTGCGGAAGAA	0.542	Colon(79;2 1269 8820 14841 52347)		NA											21	44					1.87028e-06	2.2728e-06	0.001882	1	0
SLC12A5	57468	broad.mit.edu	37	20	44680367	44680367	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:44680367G>T	uc010zxl.1	+	18	2380	c.2304G>T	c.(2302-2304)GTG>GTT	p.V768V	SLC12A5_uc002xrb.2_Silent_p.V745V	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	768					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCCAGGTGGTGATCTCCTCCA	0.627			NA											15	68					0.000219431	0.000244291	0.00245	1	0
ATP9A	10079	broad.mit.edu	37	20	50346457	50346457	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:50346457C>A	uc002xwg.1	-	2	129	c.129G>T	c.(127-129)CTG>CTT	p.L43L	ATP9A_uc010gih.1_Silent_p.L28L	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	43	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						CGGGGTGCCCCAGCCAGACAG	0.597			NA											25	69					7.38237e-10	1.01819e-09	0.00632	1	0
TSHZ2	128553	broad.mit.edu	37	20	51870965	51870965	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:51870965G>T	uc002xwo.2	+	2	1924	c.968G>T	c.(967-969)CGC>CTC	p.R323L		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	323					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GCTAAGAAACGCGTTTTTGAT	0.458			NA											18	80					7.07596e-05	8.00845e-05	0.006122	1	0
ZNF217	7764	broad.mit.edu	37	20	52193350	52193350	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:52193350C>A	uc002xwq.3	-	3	2224	c.1953G>T	c.(1951-1953)CCG>CCT	p.P651P	ZNF217_uc010gij.1_Silent_p.P643P	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	651					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.P651S(2)		skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			TACTGCCATCCGGAGGAGGAG	0.493			NA											128	133					2.87069e-51	5.50439e-51	0.00361	1	0
CBLN4	140689	broad.mit.edu	37	20	54578972	54578972	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:54578972T>C	uc002xxa.2	-	1	1041	c.256A>G	c.(256-258)ATG>GTG	p.M86V		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	86	C1q.					cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			TTGTTGCTCATCTCGGATGGC	0.647			NA											47	262					0	0	0.00361	0	0
CASS4	57091	broad.mit.edu	37	20	55012264	55012264	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:55012264T>A	uc002xxp.2	+	3	306	c.81T>A	c.(79-81)TCT>TCA	p.S27S	CASS4_uc002xxq.3_Silent_p.S27S|CASS4_uc002xxr.2_Silent_p.S27S|CASS4_uc010zze.1_Silent_p.S27S|CASS4_uc010gio.2_Silent_p.S27S	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	27	SH3.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CTGACTGCTCTGACGAGCTGG	0.572			NA											4	133					0	0	0.000602	0	0
CTCFL	140690	broad.mit.edu	37	20	56087660	56087660	+	Nonsense_Mutation	SNP	A	A	T	rs150326376		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:56087660A>T	uc010gix.1	-	7	2141	c.1479T>A	c.(1477-1479)TAT>TAA	p.Y493*	CTCFL_uc010giw.1_Nonsense_Mutation_p.Y493*|CTCFL_uc002xym.2_Nonsense_Mutation_p.Y493*|CTCFL_uc010giz.1_Nonsense_Mutation_p.Y81*|CTCFL_uc010giy.1_Nonsense_Mutation_p.Y163*|CTCFL_uc010gja.1_Nonsense_Mutation_p.Y443*|CTCFL_uc010gjb.1_Nonsense_Mutation_p.Y493*|CTCFL_uc010gjc.1_Nonsense_Mutation_p.Y493*|CTCFL_uc010gjd.1_Nonsense_Mutation_p.Y493*|CTCFL_uc010gje.2_Nonsense_Mutation_p.Y493*|CTCFL_uc010gjf.2_Nonsense_Mutation_p.Y288*|CTCFL_uc010gjg.2_Nonsense_Mutation_p.Y225*|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Nonsense_Mutation_p.Y288*|CTCFL_uc010gjj.1_Nonsense_Mutation_p.Y493*	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	493	C2H2-type 9.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GCTTGCAGGCATAACTGCAGT	0.463			NA											33	127					0	0	0.003755	0	0
GNAS	2778	broad.mit.edu	37	20	57485075	57485075	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:57485075T>C	uc002xzw.2	+	11	3123	c.2838T>C	c.(2836-2838)GCT>GCC	p.A946A	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Silent_p.A244A|GNAS_uc002xzx.2_Silent_p.A244A|GNAS_uc010gjr.2_Silent_p.A194A|GNAS_uc002xzy.2_Silent_p.A229A|GNAS_uc002yaa.2_Silent_p.A289A|GNAS_uc010zzt.1_Silent_p.A304A|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Silent_p.A194A|GNAS_uc002yae.2_Silent_p.A228A	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	303					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AAGTCCTTGCTGGGAAATCGA	0.507	Colon(117;935 1597 6045 8307 46442)		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			31	190					0	0	0.002445	0	0
TH1L	51497	broad.mit.edu	37	20	57565975	57565975	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:57565975G>C	uc002yag.2	+	8	853	c.826G>C	c.(826-828)GCC>CCC	p.A276P	TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Missense_Mutation_p.A276P	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	276					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			AGGTCATGACGCCAGTCAGAT	0.507			NA											63	78					0	0	0.00361	0	0
DIDO1	11083	broad.mit.edu	37	20	61512318	61512318	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:61512318G>A	uc002ydr.1	-	16	5254	c.4990C>T	c.(4990-4992)CCT>TCT	p.P1664S	DIDO1_uc002yds.1_Missense_Mutation_p.P1664S	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1664					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GCGCCGCAAGGCGGTGTGGGC	0.731	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											4	20					0	0	0.009096	0	0
OPRL1	4987	broad.mit.edu	37	20	62730101	62730101	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr20:62730101G>T	uc002yic.2	+	5	1464	c.1062G>T	c.(1060-1062)AAG>AAT	p.K354N	OPRL1_uc002yid.2_Missense_Mutation_p.K354N|OPRL1_uc002yif.3_Missense_Mutation_p.K349N	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	354	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GCATTGCCAAGGACGTGGCCC	0.642			NA											14	18					1.05317e-09	1.43896e-09	0.00245	1	0
HSPA13	6782	broad.mit.edu	37	21	15753637	15753637	+	Missense_Mutation	SNP	C	C	A	rs140867763		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:15753637C>A	uc002yjt.2	-	2	322	c.253G>T	c.(253-255)GTA>TTA	p.V85L	HSPA13_uc011abx.1_5'UTR	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	85						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						GCCAGCTCTACGCTTTCATAT	0.403			NA											29	67					1.12875e-08	1.48658e-08	0.00632	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28296446	28296446	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:28296446G>T	uc002ymg.2	-	8	3448	c.2719C>A	c.(2719-2721)CGG>AGG	p.R907R		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	907	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCTAACTTCCGGTTTCCATCC	0.527	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											19	41					6.94344e-10	9.60243e-10	0.006122	1	0
KRTAP24-1	643803	broad.mit.edu	37	21	31655173	31655173	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:31655173G>T	uc002ynv.2	-	1	104	c.78C>A	c.(76-78)ATC>ATA	p.I26I		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	26						keratin filament	structural molecule activity				0						AGGTCACTGGGATATAACAGT	0.493			NA											11	37					6.40141e-05	7.26916e-05	0.000978	1	0
KRTAP26-1	388818	broad.mit.edu	37	21	31691968	31691968	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:31691968A>T	uc002ynw.2	-	1	640	c.386T>A	c.(385-387)CTC>CAC	p.L129H		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	129						intermediate filament				ovary(1)	1						GTAACTATTGAGCAGCGGCCT	0.532			NA											26	139					0	0	0.003954	0	0
C21orf45	54069	broad.mit.edu	37	21	33651133	33651133	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:33651133C>A	uc002ypi.2	-	1	244	c.193G>T	c.(193-195)GAG>TAG	p.E65*	C21orf45_uc011adn.1_Nonsense_Mutation_p.E65*	NM_018944	NP_061817	Q9NYP9	MS18A_HUMAN	chromosome 21 open reading frame 45	65					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm					0						TGCGCCCTCTCCATGTCGGCC	0.692			NA											4	4					0.00909568	0.00956356	0.009096	1	0
PCP4	5121	broad.mit.edu	37	21	41239372	41239372	+	Translation_Start_Site	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:41239372C>A	uc002yyp.2	+	1	26	c.-55C>A	c.(-57--53)CCCTG>CCATG			NM_006198	NP_006189	P48539	PCP4_HUMAN	Purkinje cell protein 4						central nervous system development	cytosol|nucleus				large_intestine(1)	1		Prostate(19;2.65e-06)|all_epithelial(19;0.138)				GCAGCGACCCCTGAGCAGTGT	0.552			NA									OREG0026223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	37					0.00244969	0.00263258	0.00245	1	0
DSCAM	1826	broad.mit.edu	37	21	42080435	42080435	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:42080435G>T	uc002yyq.1	-	2	758	c.306C>A	c.(304-306)TGC>TGA	p.C102*	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	102	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTTCAGCTGTGCAATAATAAG	0.478	Melanoma(134;970 1778 1785 21664 32388)		NA											34	92					9.8876e-21	1.73033e-20	0.004878	1	0
UBASH3A	53347	broad.mit.edu	37	21	43863444	43863444	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:43863444C>A	uc002zbe.2	+	13	1690	c.1654C>A	c.(1654-1656)CTC>ATC	p.L552I	UBASH3A_uc002zbf.2_Missense_Mutation_p.L514I|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Intron	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	552	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						CCTGTCCGCCCTCATGCCGGC	0.597			NA											9	19					7.48243e-07	9.20222e-07	0.006214	1	0
TRAPPC10	7109	broad.mit.edu	37	21	45522796	45522796	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:45522796G>A	uc002zea.2	+	22	3653	c.3484G>A	c.(3484-3486)GTC>ATC	p.V1162I	TRAPPC10_uc010gpo.2_Missense_Mutation_p.V873I|TRAPPC10_uc011afa.1_Missense_Mutation_p.V540I	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1162					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CCTGCCCGACGTCAGGCTGTT	0.557			NA											23	56					0	0	0.003954	0	0
AIRE	326	broad.mit.edu	37	21	45713743	45713743	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:45713743C>G	uc002zei.2	+	11	1477	c.1350C>G	c.(1348-1350)GCC>GCG	p.A450A	AIRE_uc010gpq.2_RNA|AIRE_uc002zej.2_Silent_p.A253A|AIRE_uc010gpr.2_Silent_p.A253A	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	450	PHD-type 2.			CGDGTDVLRCTHCAAAFHWRCHFPAGTSRPG -> W (in Ref. 3; CAA08759).	positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		CTCACTGCGCCGCTGCCTTCC	0.642			NA							Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				4	17					0	0	0.000602	0	0
ITGB2	3689	broad.mit.edu	37	21	46330268	46330268	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr21:46330268C>T	uc002zgd.2	-	2	122	c.78G>A	c.(76-78)ACG>ACA	p.T26T	ITGB2_uc002zge.2_Silent_p.T26T|ITGB2_uc002zgf.3_Silent_p.T26T|ITGB2_uc011afl.1_5'UTR|ITGB2_uc010gpw.2_Silent_p.T26T|ITGB2_uc002zgg.2_Silent_p.T26T	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	26	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CCTTGAACTTCGTGCACTCCT	0.662			NA											4	33					0	0	0.000602	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072821	17072821	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:17072821G>C	uc002zlp.1	-	1	880	c.620C>G	c.(619-621)GCG>GGG	p.A207G		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	207					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.A207V(1)		ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCCGGGCAGCGCGCACACCCC	0.617			NA											21	40					0	0	0.00333	0	0
DGCR14	8220	broad.mit.edu	37	22	19130301	19130301	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:19130301C>A	uc002zou.2	-	2	279	c.242G>T	c.(241-243)CGC>CTC	p.R81L	DGCR14_uc002zot.2_Missense_Mutation_p.R2L|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	81					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)					GGCAATCTGGCGCATCCGTTC	0.582			NA											28	114					9.80776e-20	1.69316e-19	0.00632	1	0
ZDHHC8	29801	broad.mit.edu	37	22	20127706	20127706	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:20127706T>G	uc002zrq.2	+	5	732	c.626T>G	c.(625-627)GTG>GGG	p.V209G	ZDHHC8_uc002zrr.1_Missense_Mutation_p.V209G|ZDHHC8_uc010gsa.2_Intron	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	209	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					TTCCATGTGGTGCTGGTCACT	0.642			NA											5	128					0	0	0.001168	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20128827	20128827	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:20128827A>C	uc002zrq.2	+	8	1088	c.982A>C	c.(982-984)AGT>CGT	p.S328R	ZDHHC8_uc002zrr.1_Missense_Mutation_p.S328R|ZDHHC8_uc010gsa.2_Missense_Mutation_p.S134R	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	328	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					CACGTTCAGCAGTGACCTGCA	0.647			NA											4	90					0	0	0.000602	0	0
PI4KA	5297	broad.mit.edu	37	22	21147516	21147516	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:21147516C>T	uc002zsz.3	-	19	2350	c.2119G>A	c.(2119-2121)GGG>AGG	p.G707R		NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	707					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCCAAGTTCCCTGCACTGCTA	0.333	GBM(136;1332 1831 3115 23601 50806)		NA											6	473					0	0	0.001984	0	0
LZTR1	8216	broad.mit.edu	37	22	21349315	21349315	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:21349315G>T	uc002zto.2	+	16	2045	c.1942G>T	c.(1942-1944)GGC>TGC	p.G648C	LZTR1_uc002ztn.2_Missense_Mutation_p.G607C|LZTR1_uc011ahy.1_Missense_Mutation_p.G629C|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	648					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AGTGGACATTGGTAGGGAGCC	0.647			NA											343	36					4.40133e-195	8.55163e-195	0.00361	1	0
P2RX6	9127	broad.mit.edu	37	22	21380577	21380577	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:21380577G>T	uc010gsu.1	+	11	1087	c.1087G>T	c.(1087-1089)GAT>TAT	p.D363Y	P2RX6_uc002ztz.2_Missense_Mutation_p.D337Y|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	363	Cytoplasmic (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						GCTGTATGTGGATAGAGAAGC	0.453			NA											7	97					5.68852e-11	8.1424e-11	0.004482	1	0
VPREB1	7441	broad.mit.edu	37	22	22599662	22599662	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:22599662G>T	uc002zvx.1	+	2	377	c.351G>T	c.(349-351)ATG>ATT	p.M117I	LOC96610_uc011aim.1_Intron	NM_007128	NP_009059	P12018	VPREB_HUMAN	immunoglobulin iota chain precursor	117	Ig-like V-type.				immune response	extracellular region	antigen binding|protein binding				0	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		ACTGTGCTATGGGGGCCCGCA	0.453			NA											9	16					1.76689e-08	2.29449e-08	0.006214	1	0
SUSD2	56241	broad.mit.edu	37	22	24582315	24582315	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:24582315G>T	uc002zzn.1	+	10	1618	c.1574G>T	c.(1573-1575)GGA>GTA	p.G525V		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	525	VWFD.|Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						AACAGGACCGGAGGTCTGGAG	0.652			NA											9	25					5.4927e-09	7.29032e-09	0.004482	1	0
C22orf13	83606	broad.mit.edu	37	22	24939994	24939994	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:24939994C>A	uc003aah.2	-	5	760	c.444G>T	c.(442-444)GTG>GTT	p.V148V	C22orf13_uc003aal.2_Silent_p.V204V|C22orf13_uc003aai.3_Intron|C22orf13_uc003aaj.3_Silent_p.V148V|C22orf13_uc003aak.3_Silent_p.V204V	NM_031444	NP_113632	Q96NT3	CV013_HUMAN	chromosome 22 open reading frame 13	148											0						AGTTCACCAGCACGATGGCCA	0.652			NA											10	25					1.76689e-08	2.29449e-08	0.006214	1	0
LIMK2	3985	broad.mit.edu	37	22	31661989	31661989	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:31661989G>C	uc003akh.2	+	8	1057	c.912G>C	c.(910-912)CTG>CTC	p.L304L	LIMK2_uc003akg.2_Silent_p.L221L|LIMK2_uc003aki.2_Silent_p.L58L|LIMK2_uc003akj.2_Silent_p.L283L|LIMK2_uc003akk.2_Silent_p.L283L|LIMK2_uc011aln.1_Silent_p.L221L	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	304						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2						AGCCCCTGCTGTTCAGCCGTG	0.572			NA											24	58					0	0	0.00333	0	0
ISX	91464	broad.mit.edu	37	22	35478514	35478514	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:35478514G>A	uc003anj.2	+	2	1184	c.233G>A	c.(232-234)GGA>GAA	p.G78E	ISX_uc011amg.1_Missense_Mutation_p.G66E	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	78						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						CATGCAGAAGGAAGGAAGAGC	0.547			NA											10	34					0	0	0.008291	0	0
APOL6	80830	broad.mit.edu	37	22	36055359	36055359	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:36055359G>T	uc003aoe.2	+	3	1042	c.748G>T	c.(748-750)GCC>TCC	p.A250S	APOL6_uc003aod.2_RNA	NM_030641	NP_085144	Q9BWW8	APOL6_HUMAN	apolipoprotein L6	250					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity				0						CTATGACTTGGCCACTCTCTC	0.542			NA											9	38					5.4927e-09	7.29032e-09	0.004482	1	0
PICK1	9463	broad.mit.edu	37	22	38468617	38468617	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:38468617G>A	uc003auq.2	+	9	1080	c.690G>A	c.(688-690)CCG>CCA	p.P230P	PICK1_uc003aur.2_Silent_p.P230P|PICK1_uc003aus.2_Silent_p.P230P|PICK1_uc003aut.2_Silent_p.P230P	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	230	AH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					CCATCAAGCCGGTAGGTCCTA	0.428			NA											21	60					0	0	0.004656	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823948	38823948	+	Missense_Mutation	SNP	C	C	A	rs147603955	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:38823948C>A	uc003avs.1	-	2	287	c.190G>T	c.(190-192)GCG>TCG	p.A64S	KCNJ4_uc003avt.1_Missense_Mutation_p.A64S	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	64	Helical; Name=M1; (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					AGGAAGGCCGCGGAGAAGATC	0.577			NA											27	41					1.77063e-15	2.88151e-15	0.005443	1	0
TTLL12	23170	broad.mit.edu	37	22	43575638	43575638	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:43575638G>C	uc003bdq.2	-	5	859	c.827C>G	c.(826-828)GCC>GGC	p.A276G	TTLL12_uc003bdr.1_Missense_Mutation_p.A276G	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	276					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				GTAGTGCTCGGCGGGCGGCTC	0.622			NA											3	66					0	0	0.009096	0	0
TTLL12	23170	broad.mit.edu	37	22	43576790	43576790	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:43576790C>T	uc003bdq.2	-	3	536	c.504G>A	c.(502-504)GAG>GAA	p.E168E	TTLL12_uc003bdr.1_Silent_p.E168E	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	168					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				TCCACATCTCCTCCAGCACCA	0.657			NA											38	69					0	0	0.006999	0	0
CELSR1	9620	broad.mit.edu	37	22	46795763	46795763	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:46795763C>A	uc003bhw.1	-	10	5263	c.5263G>T	c.(5263-5265)GGC>TGC	p.G1755C	CELSR1_uc011arc.1_Missense_Mutation_p.G76C	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1755	Extracellular (Potential).|Laminin G-like 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCGGAGGGGCCGTGGGACACC	0.547			NA											11	33					0.00185496	0.00201036	0.001855	1	0
CELSR1	9620	broad.mit.edu	37	22	46931390	46931390	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:46931390C>A	uc003bhw.1	-	1	1678	c.1678G>T	c.(1678-1680)GAC>TAC	p.D560Y		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	560	Extracellular (Potential).|Cadherin 3.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGCTCGTTGTCGTTGACATCC	0.607			NA											9	35					0.00448238	0.00478183	0.004482	1	0
BRD1	23774	broad.mit.edu	37	22	50197939	50197939	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:50197939G>A	uc003biv.2	-	2	1924	c.1437C>T	c.(1435-1437)TAC>TAT	p.Y479Y	BRD1_uc011arf.1_Silent_p.Y74Y|BRD1_uc011arg.1_Silent_p.Y533Y|BRD1_uc011arh.1_Silent_p.Y479Y|BRD1_uc003biu.3_Silent_p.Y479Y	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	479					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGAGCAGCCAGTAGCTGTGGG	0.567			NA											11	32					0	0	0.000978	0	0
CNTN6	27255	broad.mit.edu	37	3	1444003	1444003	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:1444003T>A	uc003boz.2	+	22	3086	c.2819T>A	c.(2818-2820)ATT>AAT	p.I940N	CNTN6_uc011asj.1_Missense_Mutation_p.I868N|CNTN6_uc003bpa.2_Missense_Mutation_p.I940N	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	940	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTTATTCAGATTCTGTACCGG	0.348			NA											17	35					0	0	0.007413	0	0
NUP210	23225	broad.mit.edu	37	3	13360750	13360750	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:13360750C>A	uc003bxv.1	-	38	5542	c.5459G>T	c.(5458-5460)GGG>GTG	p.G1820V		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1820	Helical; (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GACCGCTGTCCCAGCCAACAG	0.562			NA											9	6					0.000274275	0.00030271	0.004482	1	0
C3orf20	84077	broad.mit.edu	37	3	14799156	14799156	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:14799156G>T	uc003byy.2	+	13	2623	c.2219G>T	c.(2218-2220)CGG>CTG	p.R740L	C3orf20_uc003byz.2_Missense_Mutation_p.R618L|C3orf20_uc003bza.2_Missense_Mutation_p.R618L|C3orf20_uc003bzb.1_Missense_Mutation_p.R241L|C3orf20_uc011avj.1_Missense_Mutation_p.R67L	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	740						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						CACCAGCAGCGGGGCCGTGGC	0.637			NA											10	11					0.000978159	0.00106576	0.000978	1	0
PDCD6IP	10015	broad.mit.edu	37	3	33906811	33906811	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:33906811C>T	uc003cfx.2	+	17	2476	c.2321C>T	c.(2320-2322)CCA>CTA	p.P774L	PDCD6IP_uc003cfy.2_Missense_Mutation_p.P779L|PDCD6IP_uc011axw.1_Missense_Mutation_p.P555L	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	774	Pro-rich.|Interaction with EIAV p9.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						GCTACTGCTCCATCTCCAGTG	0.597			NA											12	29					0	0	0.00245	0	0
MYRIP	25924	broad.mit.edu	37	3	39942313	39942313	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:39942313G>C	uc003cka.2	+	2	141	c.6G>C	c.(4-6)GGG>GGC	p.G2G	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.G2G|MYRIP_uc010hhw.2_5'UTR|MYRIP_uc010hhx.1_Silent_p.G2G	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	2					intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		TAACCATGGGGAGGAAGCTGG	0.398			NA											59	45					0	0	0.00361	0	0
ZNF619	285267	broad.mit.edu	37	3	40529172	40529172	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:40529172C>A	uc011azb.1	+	6	1569	c.1291C>A	c.(1291-1293)CAG>AAG	p.Q431K	ZNF619_uc010hhz.2_Missense_Mutation_p.Q382K|ZNF619_uc003ckj.2_Missense_Mutation_p.Q375K|ZNF619_uc011azc.1_Missense_Mutation_p.Q391K|ZNF619_uc011azd.1_Missense_Mutation_p.Q347K|ZNF619_uc011aza.1_Missense_Mutation_p.Q333K	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	431					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TCTTCAGCACCAGAGGTTCCA	0.458			NA											38	29					1.30015e-28	2.39415e-28	0.004878	1	0
ZDHHC3	51304	broad.mit.edu	37	3	44975430	44975430	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:44975430C>G	uc003cod.2	-	4	752	c.478G>C	c.(478-480)GTC>CTC	p.V160L	ZDHHC3_uc003cog.2_Missense_Mutation_p.V160L|ZDHHC3_uc011bad.1_Missense_Mutation_p.V160L	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	160	Cytoplasmic (Potential).|DHHC-type.					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		CAGTTGTTGACCCAGGGACAG	0.532			NA											8	323					0	0	0.00308	0	0
ALS2CL	259173	broad.mit.edu	37	3	46723032	46723032	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:46723032C>G	uc003cqa.1	-	12	1422	c.1232G>C	c.(1231-1233)TGT>TCT	p.C411S	ALS2CL_uc003cpz.1_5'UTR|ALS2CL_uc003cqb.1_Missense_Mutation_p.C411S|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	411	MORN 3.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TCGCCAGTGACACTTGTAACA	0.612			NA											33	18					0	0	0.003755	0	0
SETD2	29072	broad.mit.edu	37	3	47158147	47158147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:47158147C>A	uc003cqs.2	-	4	4605	c.4552G>T	c.(4552-4554)GAA>TAA	p.E1518*	SETD2_uc003cqv.2_Nonsense_Mutation_p.E1507*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1518	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AGACAATCTTCCCCACATGCT	0.338			NA	N|F|S|Mis		clear cell renal carcinoma								48	65					1.56989e-16	2.60883e-16	0.00361	1	0
DHX30	22907	broad.mit.edu	37	3	47870539	47870539	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:47870539C>T	uc003cru.2	+	6	707	c.281C>T	c.(280-282)CCC>CTC	p.P94L	DHX30_uc003crs.2_Missense_Mutation_p.P55L|DHX30_uc003crt.2_Missense_Mutation_p.P55L|DHX30_uc010hjr.1_Missense_Mutation_p.P122L	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	94	DRBM.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ATAAAATGGCCCAAGAGCGTG	0.498			NA											5	7					0	0	0.000602	0	0
DNAH1	25981	broad.mit.edu	37	3	52432999	52432999	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:52432999T>A	uc011bef.1	+	76	12484	c.12223T>A	c.(12223-12225)TGG>AGG	p.W4075R	DNAH1_uc003ddv.2_Missense_Mutation_p.W933R	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	4140					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCCTGAGCTCTGGAGTGCCAA	0.562			NA											19	33					0	0	0.006122	0	0
CADPS	8618	broad.mit.edu	37	3	62467524	62467524	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:62467524G>T	uc003dll.2	-	22	3407	c.3047C>A	c.(3046-3048)CCC>CAC	p.P1016H	CADPS_uc003dlj.1_5'UTR|CADPS_uc003dlk.1_Intron|CADPS_uc003dlm.2_Intron|CADPS_uc003dln.2_Intron	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1016	MHD1.|Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GTTCACATTGGGTAGGTTACT	0.433			NA											55	54					2.69953e-25	4.9004e-25	0.00361	1	0
CADPS	8618	broad.mit.edu	37	3	62535709	62535709	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:62535709C>A	uc003dll.2	-	11	2195	c.1835G>T	c.(1834-1836)CGC>CTC	p.R612L	CADPS_uc003dlk.1_Missense_Mutation_p.R116L|CADPS_uc003dlm.2_Missense_Mutation_p.R612L|CADPS_uc003dln.2_Missense_Mutation_p.R612L	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	612	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CCACAGGATGCGGTCTTGTTC	0.557			NA											74	63					3.52879e-18	6.03081e-18	0.00361	1	0
CNTN3	5067	broad.mit.edu	37	3	74334493	74334493	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:74334493A>G	uc003dpm.1	-	19	2747	c.2667T>C	c.(2665-2667)CCT>CCC	p.P889P		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	889	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TGGCGCTAAAAGGCCCAGCGC	0.473			NA											38	121					0	0	0.007835	0	0
CNTN3	5067	broad.mit.edu	37	3	74411127	74411127	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:74411127C>G	uc003dpm.1	-	10	1358	c.1278G>C	c.(1276-1278)CTG>CTC	p.L426L		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	426	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CCAAGCTGACCAGGCTGCCCA	0.502			NA											36	38					0	0	0.004878	0	0
CNTN3	5067	broad.mit.edu	37	3	74413689	74413689	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:74413689G>T	uc003dpm.1	-	9	1222	c.1142C>A	c.(1141-1143)TCT>TAT	p.S381Y		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	381	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GAACATGCCAGAATCAGTCAC	0.368			NA											17	54					8.28177e-16	1.35641e-15	0.007413	1	0
OR5K4	403278	broad.mit.edu	37	3	98073296	98073296	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:98073296A>G	uc011bgv.1	+	1	599	c.599A>G	c.(598-600)TAT>TGT	p.Y200C		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	200	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CTAATGATATATATCTTTTCA	0.333			NA											11	49					0	0	0.000978	0	0
OR5K1	26339	broad.mit.edu	37	3	98188804	98188804	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:98188804C>A	uc003dsm.2	+	1	384	c.384C>A	c.(382-384)AAC>AAA	p.N128K		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						CCATATGCAACCCACTGCAGT	0.468			NA											55	51					1.39843e-22	2.49423e-22	0.00361	1	0
NR1I2	8856	broad.mit.edu	37	3	119533825	119533825	+	Splice_Site	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:119533825G>T	uc003edj.2	+	6	2634	c.795_splice	c.e6-1	p.R265_splice	NR1I2_uc003edi.2_Splice_Site_p.R228_splice|NR1I2_uc003edk.2_Splice_Site_p.R304_splice|NR1I2_uc003edl.2_Splice_Site_p.R153_splice	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2						drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CTTGCTGCCAGGGACTTGCCC	0.602			NA											14	42					3.27435e-08	4.22524e-08	0.00245	1	0
GPR156	165829	broad.mit.edu	37	3	119900182	119900182	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:119900182G>T	uc011bjf.1	-	7	723	c.723C>A	c.(721-723)TAC>TAA	p.Y241*	GPR156_uc011bjg.1_Nonsense_Mutation_p.Y237*	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	241	Helical; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		GGCCAGCCAGGTAGGCACCAT	0.557			NA											25	97					1.38267e-23	2.50104e-23	0.005443	1	0
IQCB1	9657	broad.mit.edu	37	3	121489381	121489381	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:121489381C>G	uc010hre.1	-	15	1823	c.1608G>C	c.(1606-1608)GAG>GAC	p.E536D	IQCB1_uc003eek.2_Missense_Mutation_p.E403D|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	536					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		TTAGGAAGAGCTCAGGTTCTT	0.522			NA											6	374					0	0	0.001168	0	0
SEMA5B	54437	broad.mit.edu	37	3	122629686	122629686	+	Splice_Site	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:122629686C>G	uc003efz.1	-	22	3601	c.3297_splice	c.e22+1	p.K1099_splice	SEMA5B_uc011bju.1_Splice_Site_p.K1005_splice|SEMA5B_uc003ega.1_Splice_Site|SEMA5B_uc003efy.1_Splice_Site_p.K77_splice	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1						cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		aaGGCTCCCACCTTGAATTCC	0.308			NA											32	24					0	0	0.003271	0	0
ADCY5	111	broad.mit.edu	37	3	123166346	123166346	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:123166346G>T	uc003egh.1	-	1	1047	c.1047C>A	c.(1045-1047)GCC>GCA	p.A349A		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	349					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGAGCACTGCGGCCCGCATGC	0.682			NA											10	28					2.68362e-12	4.01561e-12	0.001368	1	0
C3orf22	152065	broad.mit.edu	37	3	126270897	126270897	+	Missense_Mutation	SNP	G	G	T	rs145199781	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:126270897G>T	uc003ejb.2	-	3	487	c.158C>A	c.(157-159)ACG>AAG	p.T53K		NM_152533	NP_689746	Q8N5N4	CC022_HUMAN	hypothetical protein LOC152065	53											0				GBM - Glioblastoma multiforme(114;0.147)		CAGCTGCACCGTGTTCGAGTC	0.622			NA											15	83					4.93089e-13	7.56662e-13	0.00245	1	0
IFT122	55764	broad.mit.edu	37	3	129239079	129239079	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:129239079C>T	uc003emm.2	+	30	3903	c.3697C>T	c.(3697-3699)CGC>TGC	p.R1233C	IFT122_uc003eml.2_Missense_Mutation_p.R1284C|IFT122_uc003emn.2_Missense_Mutation_p.R1174C|IFT122_uc003emo.2_Missense_Mutation_p.R1123C|IFT122_uc003emp.2_Missense_Mutation_p.R1083C|IFT122_uc010htc.2_Missense_Mutation_p.R1226C|IFT122_uc011bky.1_Missense_Mutation_p.R1024C|IFT122_uc003emq.2_Missense_Mutation_p.R1073C|IFT122_uc003emr.2_Missense_Mutation_p.R986C|IFT122_uc011bla.1_Missense_Mutation_p.R1007C|IFT122_uc010hte.2_Missense_Mutation_p.R559C|IFT122_uc003ems.2_Missense_Mutation_p.R615C	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	1233					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						CCCCTACTGCCGCAGGTGCAA	0.582			NA											8	15					0	0	0.006214	0	0
COL29A1	256076	broad.mit.edu	37	3	130188091	130188091	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:130188091G>T	uc010htj.1	+	38	7737	c.7243G>T	c.(7243-7245)GCT>TCT	p.A2415S	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.A454S	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	2415	VWFA 10.|Nonhelical region.				axon guidance|cell adhesion	collagen					0						TGTAATATCTGCTGGCGAAAC	0.413			NA											27	77					1.17739e-12	1.79062e-12	0.005443	1	0
COL6A6	131873	broad.mit.edu	37	3	130290119	130290119	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:130290119C>G	uc010htl.2	+	6	2890	c.2859C>G	c.(2857-2859)CCC>CCG	p.P953P		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	953	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GTGCCAATCCCGTGGAGCTGT	0.507			NA											29	56					0	0	0.009535	0	0
PIK3R4	30849	broad.mit.edu	37	3	130427168	130427168	+	Missense_Mutation	SNP	C	C	A	rs151220675		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:130427168C>A	uc003enj.2	-	10	3081	c.2500G>T	c.(2500-2502)GTT>TTT	p.V834F		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	834					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity	p.V834F(1)		ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TTGGTTTTAACAAGATCAACT	0.388			NA											21	241					3.10358e-05	3.62498e-05	0.002299	1	0
PIK3R4	30849	broad.mit.edu	37	3	130435261	130435261	+	Silent	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:130435261A>C	uc003enj.2	-	9	2891	c.2310T>G	c.(2308-2310)CTT>CTG	p.L770L		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	770					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						ACTTCTTCAGAAGCTGTGCTA	0.398			NA											70	60					0	0	0.00361	0	0
ACPP	55	broad.mit.edu	37	3	132075604	132075604	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:132075604G>T	uc010htp.2	+	10	1133	c.1043G>T	c.(1042-1044)AGC>ATC	p.S348I	ACPP_uc003eon.3_Missense_Mutation_p.S315I|ACPP_uc003eop.3_Missense_Mutation_p.S348I	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	348						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						CCTGGCTGCAGCCCCAGCTGT	0.557			NA											7	143					3.86212e-05	4.42498e-05	0.008291	1	0
NPHP3	27031	broad.mit.edu	37	3	132407565	132407565	+	Silent	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:132407565A>T	uc003epe.1	-	21	3131	c.3054T>A	c.(3052-3054)GCT>GCA	p.A1018A	NPHP3_uc003epd.1_Silent_p.A260A	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	1018	TPR 5.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CCGCACCATAAGCATTTTCTG	0.413			NA											25	259					0	0	0.005443	0	0
IL20RB	53833	broad.mit.edu	37	3	136701172	136701172	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:136701172A>G	uc003eri.1	+	3	635	c.386A>G	c.(385-387)CAT>CGT	p.H129R	IL20RB_uc003erj.1_RNA|IL20RB_uc010hud.1_5'UTR	NM_144717	NP_653318	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta precursor	129	Fibronectin type-III 1.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1						ATCCTGAAGCATCCCTTTAAT	0.507			NA											14	41					0	0	0.00245	0	0
CLSTN2	64084	broad.mit.edu	37	3	140265370	140265370	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:140265370C>A	uc003etn.2	+	10	1711	c.1521C>A	c.(1519-1521)ACC>ACA	p.T507T	CLSTN2_uc003etm.2_Silent_p.T507T	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	507	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GAGAAGTCACCAAACCACAGT	0.522	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			17	42					4.96729e-08	6.3776e-08	0.008871	1	0
ZIC1	7545	broad.mit.edu	37	3	147128064	147128064	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:147128064G>C	uc003ewe.2	+	1	884	c.165G>C	c.(163-165)GAG>GAC	p.E55D		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	55					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTTCGCACGAGCTGGCTTCGG	0.711			NA											4	38					0	0	0.001168	0	0
ZIC1	7545	broad.mit.edu	37	3	147128846	147128846	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:147128846C>G	uc003ewe.2	+	1	1666	c.947C>G	c.(946-948)TCC>TGC	p.S316C		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	316	C2H2-type 3.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TTCGCGCGCTCCGAGAATTTA	0.552			NA											19	22					0	0	0.006122	0	0
CPA3	1359	broad.mit.edu	37	3	148614351	148614351	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:148614351A>T	uc003ewm.2	+	11	1163	c.1111A>T	c.(1111-1113)ATC>TTC	p.I371F		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	371					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TGACCTGGGCATCAAACACAC	0.403			NA											24	97					0	0	0.007291	0	0
IGSF10	285313	broad.mit.edu	37	3	151156246	151156246	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:151156246G>A	uc011bod.1	-	6	6103	c.6103C>T	c.(6103-6105)CTG>TTG	p.L2035L	IGSF10_uc011bob.1_Silent_p.L62L|IGSF10_uc011boc.1_Silent_p.L14L	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2035					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGGTTTCAGTCTTAGGCTA	0.433			NA											30	133					0	0	0.008361	0	0
IGSF10	285313	broad.mit.edu	37	3	151162958	151162958	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:151162958G>T	uc011bod.1	-	4	4811	c.4811C>A	c.(4810-4812)ACC>AAC	p.T1604N		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1604					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AACAAGAGTGGTGGCCTCGGA	0.428			NA											31	148					7.11191e-15	1.14283e-14	0.002836	1	0
IGSF10	285313	broad.mit.edu	37	3	151162966	151162966	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:151162966G>T	uc011bod.1	-	4	4803	c.4803C>A	c.(4801-4803)TCC>TCA	p.S1601S		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1601					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGGTGGCCTCGGACAGGCCTG	0.443			NA											31	139					2.61193e-14	4.15147e-14	0.009535	1	0
MME	4311	broad.mit.edu	37	3	154802043	154802044	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:154802043_154802044CA>AG	uc010hvr.1	+	2	298_299	c.87_88CA>AG	c.(85-90)ATCAGC>ATAGGC	p.S30G	MME_uc003fab.1_Missense_Mutation_p.S30G|MME_uc003fac.1_Missense_Mutation_p.S30G|MME_uc003fad.1_Missense_Mutation_p.S30G|MME_uc003fae.1_Missense_Mutation_p.S30G	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	30	Helical; Signal-anchor for type II membrane protein; (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CACTGGAGATCAGCCTCTCGGT	0.48			NA											43	115					0	0	0.004672	0	0
MFSD1	64747	broad.mit.edu	37	3	158522150	158522150	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:158522150A>T	uc003fcl.1	+	2	236	c.206A>T	c.(205-207)CAA>CTA	p.Q69L	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Nonsense_Mutation_p.K10*|MFSD1_uc011bow.1_Nonsense_Mutation_p.K68*|MFSD1_uc011box.1_5'UTR	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	69					transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTTCAGACTCAAGTTAAACGA	0.368	Pancreas(62;1186 1654 36636 37908)		NA											16	34					0	0	0.008871	0	0
SI	6476	broad.mit.edu	37	3	164737500	164737500	+	Missense_Mutation	SNP	G	G	A	rs138397431	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:164737500G>A	uc003fei.2	-	28	3375	c.3313C>T	c.(3313-3315)CGC>TGC	p.R1105C		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1105	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GATGGCAGGCGAGTCGATATT	0.383			NA								HNSCC(35;0.089)			5	60					0	0	0.000602	0	0
FNDC3B	64778	broad.mit.edu	37	3	172065095	172065095	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:172065095A>C	uc003fhy.2	+	21	2630	c.2458A>C	c.(2458-2460)ACC>CCC	p.T820P	FNDC3B_uc003fhz.3_Missense_Mutation_p.T820P	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	820	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TGGGACAGACACCCGTTTTGA	0.443			NA											32	78					0	0	0.002445	0	0
FNDC3B	64778	broad.mit.edu	37	3	172065099	172065099	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:172065099G>T	uc003fhy.2	+	21	2634	c.2462G>T	c.(2461-2463)CGT>CTT	p.R821L	FNDC3B_uc003fhz.3_Missense_Mutation_p.R821L	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	821	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ACAGACACCCGTTTTGAAATA	0.448			NA											32	77					2.80507e-11	4.07793e-11	0.002445	1	0
EIF4G1	1981	broad.mit.edu	37	3	184049277	184049277	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:184049277G>C	uc003fnp.2	+	30	4476	c.4278G>C	c.(4276-4278)CTG>CTC	p.L1426L	EIF4G1_uc003fnt.2_Silent_p.L1137L|EIF4G1_uc003fnq.2_Silent_p.L1339L|EIF4G1_uc003fnr.2_Silent_p.L1262L|EIF4G1_uc010hxx.2_Silent_p.L1433L|EIF4G1_uc003fns.2_Silent_p.L1386L|EIF4G1_uc010hxy.2_Silent_p.L1433L|EIF4G1_uc003fnv.3_Silent_p.L1427L|EIF4G1_uc003fnu.3_Silent_p.L1426L|EIF4G1_uc003fnw.2_Silent_p.L1433L|EIF4G1_uc003fnx.2_Silent_p.L1231L|EIF4G1_uc003fny.3_Silent_p.L1230L|EIF4G1_uc003foa.2_Silent_p.L98L	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1426					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGTATACCCTGGGAGAGGAGT	0.577			NA											6	236					0	0	0.001168	0	0
ZNF595	152687	broad.mit.edu	37	4	59439	59439	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:59439G>T	uc003fzv.1	+	2	276	c.120G>T	c.(118-120)CTG>CTT	p.L40L	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Silent_p.L40L|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	40					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		ACAGGAACCTGGTCTCCCTGG	0.443			NA											30	404					3.1745e-13	4.90822e-13	0.008361	1	0
SH3BP2	6452	broad.mit.edu	37	4	2826407	2826407	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:2826407A>C	uc003gfi.3	+	4	427	c.307A>C	c.(307-309)AAG>CAG	p.K103Q	SH3BP2_uc010icn.2_Missense_Mutation_p.K103Q|SH3BP2_uc011bvp.1_Missense_Mutation_p.K131Q|SH3BP2_uc003gfj.3_Missense_Mutation_p.K160Q|SH3BP2_uc003gfk.3_Missense_Mutation_p.K103Q|SH3BP2_uc003gfl.3_Missense_Mutation_p.K36Q|SH3BP2_uc003gfm.3_5'Flank	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	103	PH.				signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CCATATCAGCAAGAAGCACCG	0.637			NA							Cherubism				34	55					0	0	0.00623	0	0
C4orf23	152992	broad.mit.edu	37	4	8467229	8467229	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:8467229G>T	uc003glg.1	+	8	936	c.748G>T	c.(748-750)GGC>TGC	p.G250C	C4orf23_uc003glf.1_Missense_Mutation_p.G238C|C4orf23_uc003glh.1_Missense_Mutation_p.G87C	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	479					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						TAAAGAAGTGGGCTTCACCTG	0.488			NA											38	57					3.66854e-30	6.80445e-30	0.007835	1	0
GBA3	57733	broad.mit.edu	37	4	22749027	22749027	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:22749027G>T	uc003gqp.3	+	3	486	c.395G>T	c.(394-396)GGT>GTT	p.G132V	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.G133V	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	132					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						GACCAAGGAGGTTGGTTGTCA	0.403			NA											64	107					1.22119e-34	2.30269e-34	0.00361	1	0
SLC34A2	10568	broad.mit.edu	37	4	25675965	25675965	+	Missense_Mutation	SNP	G	G	T	rs116219115	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:25675965G>T	uc003grr.2	+	11	1345	c.1264G>T	c.(1264-1266)GTC>TTC	p.V422F	SLC34A2_uc003grs.2_Missense_Mutation_p.V421F|SLC34A2_uc010iev.2_Missense_Mutation_p.V421F	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	422	Helical; Name=M5; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GGCCATCCTCGTCGGGGCAGG	0.577			NA											29	58					8.88839e-20	1.53705e-19	0.002096	1	0
CCKAR	886	broad.mit.edu	37	4	26483736	26483736	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:26483736G>T	uc003gse.1	-	5	964	c.811C>A	c.(811-813)CTG>ATG	p.L271M		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	271	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	GTCTTTTGCAGGTAACACCCA	0.602			NA											30	106					7.11191e-15	1.14283e-14	0.002836	1	0
GRXCR1	389207	broad.mit.edu	37	4	42895638	42895638	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:42895638C>T	uc003gwt.2	+	1	355	c.355C>T	c.(355-357)CTA>TTA	p.L119L		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	119					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						TGGCCAGGCTCTATTTAACAA	0.433			NA											73	90					0	0	0.00361	0	0
GABRA2	2555	broad.mit.edu	37	4	46252334	46252334	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:46252334G>T	uc003gxc.3	-	9	2020	c.1347C>A	c.(1345-1347)GTC>GTA	p.V449V	GABRA2_uc010igc.2_Silent_p.V449V|GABRA2_uc011bzc.1_Silent_p.V454V	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	449					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCAAGGACTGACCCCTAATA	0.338			NA											8	60					0.00448238	0.00478183	0.004482	1	0
ATP10D	57205	broad.mit.edu	37	4	47556860	47556860	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:47556860A>G	uc003gxk.1	+	11	1917	c.1753A>G	c.(1753-1755)ATC>GTC	p.I585V	ATP10D_uc003gxl.1_Intron	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	585	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TTTGTACATTATCGACTTTTT	0.413			NA											6	131					0	0	0.001984	0	0
ATP10D	57205	broad.mit.edu	37	4	47559954	47559954	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:47559954G>C	uc003gxk.1	+	12	2262	c.2098G>C	c.(2098-2100)GGT>CGT	p.G700R	ATP10D_uc003gxl.1_Intron	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	700	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GAAACAACACGGTGATGCAGG	0.582			NA											29	33					0	0	0.00632	0	0
LNX1	84708	broad.mit.edu	37	4	54439849	54439849	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:54439849G>C	uc003hag.3	-	2	577	c.321C>G	c.(319-321)TTC>TTG	p.F107L	PDGFRA_uc003haa.2_Intron|LNX1_uc003hah.3_RNA	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	107						cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AGTGCTCCCTGAATGGGCAGG	0.577			NA											4	7					0	0	0.001168	0	0
KDR	3791	broad.mit.edu	37	4	55981512	55981512	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:55981512T>C	uc003has.2	-	4	727	c.425A>G	c.(424-426)AAA>AGA	p.K142R	KDR_uc003hat.1_Missense_Mutation_p.K142R|KDR_uc011bzx.1_Missense_Mutation_p.K142R	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	142	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGTTTTGTTTTTGTTCTCAGT	0.358			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			18	27					0	0	0.008871	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68964603	68964603	+	Splice_Site	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:68964603A>G	uc003hdt.1	-	2	212	c.163_splice	c.e2+1	p.D55_splice		NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F						proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						CTGGATACTTACCCTCAACAA	0.353			NA											34	50					0	0	0.003755	0	0
UGT2B10	7365	broad.mit.edu	37	4	69885521	69885521	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:69885521T>A	uc011cao.1	-	4	604	c.468A>T	c.(466-468)GTA>GTT	p.V156V	UGT2B10_uc011can.1_Intron			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	193					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TAACAACAGGTACGTAGGAAG	0.383	Melanoma(133;755 1763 25578 26334 46021)		NA											24	42					0	0	0.005443	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156417	70156418	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:70156417_70156418CC>AA	uc003hej.2	+	5	1200_1201	c.1198_1199CC>AA	c.(1198-1200)CCT>AAT	p.P400N	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	400					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	TTGGGATCAACCTGATAACATT	0.45			NA											45	140					0	0	0.004672	0	0
C4orf35	85438	broad.mit.edu	37	4	71200971	71200971	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:71200971A>T	uc003hff.2	+	1	301	c.215A>T	c.(214-216)AAG>ATG	p.K72M		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	72						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				ACAGCTAAAAAGGAAAAACTC	0.373			NA											53	69					0	0	0.00361	0	0
ANKRD56	345079	broad.mit.edu	37	4	77817998	77817998	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:77817998G>T	uc003hki.2	-	1	1005	c.1005C>A	c.(1003-1005)TTC>TTA	p.F335L		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	335											0						GCAGCTGGAGGAAGTTGTCTG	0.642			NA											14	41					4.93089e-13	7.56662e-13	0.00245	1	0
FRAS1	80144	broad.mit.edu	37	4	79399131	79399131	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:79399131G>C	uc003hlb.2	+	55	8454	c.8014G>C	c.(8014-8016)GAT>CAT	p.D2672H		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2667	Extracellular (Potential).|Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CGATACCGAGGATGAACCCAC	0.453			NA											5	6					0	0	0.000602	0	0
ANXA3	306	broad.mit.edu	37	4	79503387	79503387	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:79503387G>T	uc003hld.2	+	5	565	c.255G>T	c.(253-255)GTG>GTT	p.V85V	ANXA3_uc003hle.2_Silent_p.V46V|ANXA3_uc010ijk.2_Silent_p.V46V	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	85	Annexin 1.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						ATCTCATGGTGGCCCTAGTGA	0.448	GBM(2;126 157 27790 28920 42492)		NA											9	54					1.12685e-05	1.32678e-05	0.004482	1	0
GK2	2712	broad.mit.edu	37	4	80328582	80328582	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:80328582C>T	uc003hlu.2	-	1	791	c.773G>A	c.(772-774)GGG>GAG	p.G258E		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	258					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						ACATTGGTCCCCCAAACACCC	0.458			NA											17	95					0	0	0.00499	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86844845	86844845	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:86844845C>T	uc003hpk.2	+	4	762	c.313C>T	c.(313-315)CTC>TTC	p.L105F	ARHGAP24_uc003hpj.2_Missense_Mutation_p.L105F|ARHGAP24_uc003hpl.2_Missense_Mutation_p.L10F|ARHGAP24_uc010ikf.2_Missense_Mutation_p.L20F	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	105	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		AAGCTACCTCCTCATGGCAAG	0.473			NA											7	49					0	0	0.00308	0	0
MAPK10	5602	broad.mit.edu	37	4	87028474	87028474	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:87028474C>A	uc003hpq.2	-	4	335	c.268G>T	c.(268-270)GTG>TTG	p.V90L	MAPK10_uc010ikg.2_Missense_Mutation_p.V52L|MAPK10_uc003hpr.2_Missense_Mutation_p.V52L|MAPK10_uc003hps.2_Missense_Mutation_p.V90L|MAPK10_uc003hpt.2_Missense_Mutation_p.V90L|MAPK10_uc003hpu.2_Missense_Mutation_p.V90L|MAPK10_uc003hpv.2_5'UTR|MAPK10_uc010ikh.1_RNA|MAPK10_uc003hpo.2_5'UTR|MAPK10_uc011ccw.1_5'UTR|MAPK10_uc003hpp.2_5'UTR	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	90	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		TTAATGGCCACATTTCTGTCA	0.448			NA											8	57					0.000274275	0.00030271	0.004482	1	0
DSPP	1834	broad.mit.edu	37	4	88533716	88533716	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:88533716G>T	uc003hqu.2	+	4	498	c.378G>T	c.(376-378)GGG>GGT	p.G126G		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	126					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		GAATACATGGGAAAGAAGAAA	0.413			NA											8	39					1.12685e-05	1.32678e-05	0.004482	1	0
MEPE	56955	broad.mit.edu	37	4	88766498	88766498	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:88766498G>T	uc003hqy.2	+	4	517	c.478G>T	c.(478-480)GCG>TCG	p.A160S	MEPE_uc010ikn.2_Missense_Mutation_p.A47S	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	160					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		GCCAGTGACTGCGATTAAACT	0.418			NA											8	61					0.000442599	0.000486383	0.006214	1	0
COL25A1	84570	broad.mit.edu	37	4	109895542	109895542	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:109895542T>A	uc003hze.1	-	7	1004	c.473A>T	c.(472-474)CAA>CTA	p.Q158L	COL25A1_uc003hzg.2_Missense_Mutation_p.Q158L|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_5'UTR	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	158	Extracellular (Potential).|Collagen-like 1.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTGATCACCTTGTTCTCCCTG	0.373			NA											27	59					0	0	0.002096	0	0
SEC24B	10427	broad.mit.edu	37	4	110452656	110452656	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:110452656G>T	uc003hzk.2	+	20	3423	c.3368G>T	c.(3367-3369)AGG>ATG	p.R1123M	SEC24B_uc003hzl.2_Missense_Mutation_p.R1088M|SEC24B_uc011cfp.1_Missense_Mutation_p.R1153M|SEC24B_uc011cfq.1_Missense_Mutation_p.R1122M|SEC24B_uc011cfr.1_Missense_Mutation_p.R1087M	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	1123					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		AACTTATACAGGATAGACAGA	0.348			NA											15	73					1.15088e-07	1.44674e-07	0.004007	1	0
ALPK1	80216	broad.mit.edu	37	4	113332985	113332985	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:113332985G>C	uc003iap.3	+	5	558	c.279G>C	c.(277-279)GCG>GCC	p.A93A	ALPK1_uc011cfw.1_RNA|ALPK1_uc003ian.3_Silent_p.A93A|ALPK1_uc011cfx.1_Silent_p.A15A|ALPK1_uc003iao.3_RNA|ALPK1_uc003iaq.2_Silent_p.A37A|ALPK1_uc010imo.2_5'UTR|ALPK1_uc003iar.2_Silent_p.A63A	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	93							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TCCTCCAGGCGTCCCTGAGGG	0.592			NA											3	12					0	0	0.004672	0	0
PRDM5	11107	broad.mit.edu	37	4	121774658	121774658	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:121774658T>A	uc003idn.2	-	3	465	c.215A>T	c.(214-216)GAT>GTT	p.D72V	PRDM5_uc003ido.2_Missense_Mutation_p.D72V|PRDM5_uc010ine.2_Missense_Mutation_p.D72V|PRDM5_uc010inf.2_Missense_Mutation_p.D72V|PRDM5_uc003idp.1_Missense_Mutation_p.D72V	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	72	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						GTTGGTAGCATCCAAAATGTA	0.448			NA											16	279					0	0	0.004007	0	0
FAT4	79633	broad.mit.edu	37	4	126336650	126336650	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:126336650G>C	uc003ifj.3	+	5	6532	c.6532G>C	c.(6532-6534)GCA>CCA	p.A2178P	FAT4_uc011cgp.1_Missense_Mutation_p.A476P	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2178	Cadherin 21.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACAAGTGTTCGCAGCAGATGG	0.398			NA											14	82					0	0	0.003163	0	0
FAT4	79633	broad.mit.edu	37	4	126370085	126370085	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:126370085G>T	uc003ifj.3	+	9	7914	c.7914G>T	c.(7912-7914)TGG>TGT	p.W2638C	FAT4_uc011cgp.1_Missense_Mutation_p.W936C|FAT4_uc003ifi.1_Missense_Mutation_p.W116C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2638	Extracellular (Potential).|Cadherin 25.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						atgttgtatggatagaggcca	0.129			NA											16	22					6.72482e-11	9.59884e-11	0.003163	1	0
FAT4	79633	broad.mit.edu	37	4	126373104	126373104	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:126373104G>A	uc003ifj.3	+	9	10933	c.10933G>A	c.(10933-10935)GAC>AAC	p.D3645N	FAT4_uc011cgp.1_Missense_Mutation_p.D1943N|FAT4_uc003ifi.1_Missense_Mutation_p.D1123N	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3645	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGATGTGTTAGACAGCTTCCA	0.478			NA											32	47					0	0	0.003271	0	0
USP38	84640	broad.mit.edu	37	4	144135716	144135716	+	Missense_Mutation	SNP	A	A	T	rs140701873		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:144135716A>T	uc003ijb.2	+	9	3121	c.2587A>T	c.(2587-2589)AGG>TGG	p.R863W	USP38_uc003ija.3_Missense_Mutation_p.R863W|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	863					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					TTCTTATGCCAGGAATATCAC	0.438			NA											14	31					0	0	0.00245	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160264211	160264211	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:160264211A>T	uc003iqg.3	+	15	2826	c.2516A>T	c.(2515-2517)GAT>GTT	p.D839V		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	839	Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CTATTTCAAGATCTCCAAGAC	0.418			NA											5	37					0	0	0.000602	0	0
NPY5R	4889	broad.mit.edu	37	4	164271759	164271759	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:164271759G>T	uc003iqn.2	+	4	516	c.334G>T	c.(334-336)GTC>TTC	p.V112F		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	112	Extracellular (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GTTTGGCAAAGTCATGTGCCA	0.383	Melanoma(139;1287 1774 9781 19750 25599)		NA											25	198					4.4004e-07	5.45116e-07	0.00333	1	0
GALNT7	51809	broad.mit.edu	37	4	174169425	174169425	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:174169425G>C	uc003isz.3	+	2	504	c.421G>C	c.(421-423)GAG>CAG	p.E141Q		NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	141	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		CAAAGAACCTGAGCCTCCTGG	0.493			NA											25	46					0	0	0.003954	0	0
ADAM29	11086	broad.mit.edu	37	4	175898483	175898483	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:175898483G>T	uc003iuc.2	+	5	2477	c.1807G>T	c.(1807-1809)GAG>TAG	p.E603*	ADAM29_uc003iud.2_Nonsense_Mutation_p.E603*|ADAM29_uc010irr.2_Nonsense_Mutation_p.E603*|ADAM29_uc011cki.1_Nonsense_Mutation_p.E603*	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	603	Cys-rich.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AGATGGAACAGAGTGTGGGAT	0.433	Ovarian(140;1727 1835 21805 25838 41440)		NA											26	134					4.43304e-23	7.96232e-23	0.00632	1	0
ODZ3	55714	broad.mit.edu	37	4	183601430	183601430	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:183601430C>A	uc003ivd.1	+	8	1604	c.1567C>A	c.(1567-1569)CAT>AAT	p.H523N	ODZ3_uc003ive.1_5'UTR	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	523	Extracellular (Potential).|EGF-like 1.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CCGAAATTGCCATGGAAATGG	0.423			NA											16	20					3.51602e-12	5.25346e-12	0.008871	1	0
CASP3	836	broad.mit.edu	37	4	185552920	185552920	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:185552920T>A	uc003iwh.2	-	6	745	c.482A>T	c.(481-483)CAG>CTG	p.Q161L	CASP3_uc003iwg.2_Missense_Mutation_p.Q161L|CASP3_uc003iwi.2_Missense_Mutation_p.Q161L	NM_004346	NP_004337	P42574	CASP3_HUMAN	caspase 3 preproprotein	161					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			kidney(1)	1		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	AGACATTACCTGAATAATGAA	0.338			NA											5	45					0	0	0.000602	0	0
SORBS2	8470	broad.mit.edu	37	4	186541230	186541230	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:186541230G>A	uc003iyl.2	-	14	3437	c.2579C>T	c.(2578-2580)ACT>ATT	p.T860I	SORBS2_uc003iyh.2_Missense_Mutation_p.T584I|SORBS2_uc011ckw.1_Missense_Mutation_p.T421I|SORBS2_uc003iyi.2_Missense_Mutation_p.T491I|SORBS2_uc011ckx.1_Missense_Mutation_p.T426I|SORBS2_uc003iyk.2_Missense_Mutation_p.T404I|SORBS2_uc003iym.2_Missense_Mutation_p.T960I|SORBS2_uc003iyn.1_Missense_Mutation_p.T451I|SORBS2_uc011cku.1_Missense_Mutation_p.T252I|SORBS2_uc011ckv.1_Missense_Mutation_p.T764I|SORBS2_uc003iyd.2_Missense_Mutation_p.T559I|SORBS2_uc003iye.2_Missense_Mutation_p.T433I|SORBS2_uc003iya.2_Missense_Mutation_p.T380I|SORBS2_uc003iyb.2_Missense_Mutation_p.T333I|SORBS2_uc003iyc.2_Missense_Mutation_p.T313I|SORBS2_uc003iyg.2_Missense_Mutation_p.T974I|SORBS2_uc003iyf.2_Missense_Mutation_p.T396I|SORBS2_uc003iyo.1_Missense_Mutation_p.T309I	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	860						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TTTTTCTGGAGTTCCTCTTCT	0.438	Esophageal Squamous(153;41 2433 9491 36028)		NA											7	324					0	0	0.00308	0	0
TRIML1	339976	broad.mit.edu	37	4	189068508	189068508	+	Silent	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr4:189068508A>C	uc003izm.1	+	6	1504	c.1389A>C	c.(1387-1389)TCA>TCC	p.S463S	TRIML1_uc003izn.1_Silent_p.S187S	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	463	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCATCTGCTCACTGAACAGCC	0.557	Melanoma(31;213 1036 16579 23968 32372)		NA											21	39					0	0	0.010504	0	0
EXOC3	11336	broad.mit.edu	37	5	457103	457103	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:457103G>T	uc003jba.2	+	5	1274	c.1146G>T	c.(1144-1146)ACG>ACT	p.T382T		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	393					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TGCTTGACACGTACATGTCCA	0.587			NA											21	22					5.26018e-13	8.05982e-13	0.001882	1	0
KIAA0947	23379	broad.mit.edu	37	5	5461256	5461256	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:5461256T>C	uc003jdm.3	+	13	2031	c.1809T>C	c.(1807-1809)ACT>ACC	p.T603T		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	603										ovary(1)|central_nervous_system(1)	2						AAGGGTTCACTTTAGGAGAAT	0.408			NA											44	92					0	0	0.002522	0	0
FAM173B	134145	broad.mit.edu	37	5	10227695	10227695	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:10227695C>G	uc003jeo.2	-	5	589	c.560G>C	c.(559-561)CGG>CCG	p.R187P	FAM173B_uc003jep.2_RNA|FAM173B_uc010itr.2_Missense_Mutation_p.R170P	NM_199133	NP_954584	Q6P4H8	F173B_HUMAN	hypothetical protein LOC134145	187						integral to membrane				kidney(1)|central_nervous_system(1)	2						GAAAGGGAACCGGCAAGCAAT	0.488			NA											11	40					0	0	0.001368	0	0
CTNND2	1501	broad.mit.edu	37	5	11384964	11384964	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:11384964G>T	uc003jfa.1	-	7	1135	c.990C>A	c.(988-990)CGC>CGA	p.R330R	CTNND2_uc010itt.2_Silent_p.R239R|CTNND2_uc011cmy.1_Intron|CTNND2_uc011cmz.1_Intron|CTNND2_uc010itu.1_Intron|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	330					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GCGAGGTCACGCGGATCGGGG	0.647			NA											7	8					5.18039e-06	6.17778e-06	0.00308	1	0
FBXL7	23194	broad.mit.edu	37	5	15616169	15616169	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:15616169G>C	uc003jfn.1	+	2	596	c.115G>C	c.(115-117)GCT>CCT	p.A39P		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	39					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						GAAGAATGTGGCTACCAGCGA	0.473			NA											10	25					0	0	0.008291	0	0
CDH18	1016	broad.mit.edu	37	5	19473591	19473591	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:19473591G>T	uc003jgc.2	-	12	2494	c.2117C>A	c.(2116-2118)ACC>AAC	p.T706N	CDH18_uc003jgd.2_Missense_Mutation_p.T706N|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GCTTTCCAGGGTGGATGATGT	0.493			NA											19	49					1.56452e-12	2.3653e-12	0.007413	1	0
GUSBP1	728411	broad.mit.edu	37	5	21459682	21459682	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:21459682G>T	uc010iub.2	+	1	94	c.14G>T	c.(13-15)GGG>GTG	p.G5V	GUSBP1_uc011cnn.1_Intron|GUSBP1_uc003jgh.3_RNA|GUSBP1_uc003jgf.3_Missense_Mutation_p.G5V|GUSBP1_uc003jgg.3_RNA	NR_027028				SubName: Full=Putative uncharacterized protein GUSBL2;												0						GAGCGCTCTGGGCCCAGCGAA	0.637			NA									OREG0016459	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	123					4.36969e-10	6.07595e-10	0.001855	1	0
EGFLAM	133584	broad.mit.edu	37	5	38338879	38338879	+	Missense_Mutation	SNP	C	C	A	rs74624102	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:38338879C>A	uc003jlc.1	+	3	611	c.287C>A	c.(286-288)ACC>AAC	p.T96N	EGFLAM_uc003jlb.1_Missense_Mutation_p.T96N	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	96	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GACATCCCGACCACGGTGAGT	0.522	Colon(62;485 1295 3347 17454)		NA											10	21					3.86212e-05	4.42498e-05	0.008291	1	0
LIFR	3977	broad.mit.edu	37	5	38493779	38493779	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:38493779G>T	uc010ive.1	-	14	2326	c.1994C>A	c.(1993-1995)TCT>TAT	p.S665Y	LIFR_uc003jli.2_Missense_Mutation_p.S665Y	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	665	Fibronectin type-III 5.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					TTCCGACCGAGACGAGTTACA	0.438	Melanoma(13;4 730 6426 9861 34751)		NA	T	PLAG1	salivary adenoma								36	169					3.6622e-26	6.68351e-26	0.003755	1	0
C7	730	broad.mit.edu	37	5	40950059	40950059	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:40950059G>T	uc003jmh.2	+	9	1150	c.1036G>T	c.(1036-1038)GTT>TTT	p.V346F	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	346	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GCATTTTGTCGTTAAATTTTC	0.348			NA											6	7					2.0095e-06	2.43619e-06	0.001984	1	0
PARP8	79668	broad.mit.edu	37	5	50111265	50111265	+	Splice_Site	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:50111265G>T	uc003jon.3	+	16	1758	c.1576_splice	c.e16-1	p.P526_splice	PARP8_uc011cpz.1_Splice_Site_p.P418_splice|PARP8_uc003joo.2_Splice_Site_p.P526_splice|PARP8_uc003jop.2_Splice_Site_p.P526_splice	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				TTCTTTTGTAGCCTACCGTAT	0.353			NA											12	21					4.14922e-12	6.17249e-12	0.004007	1	0
FST	10468	broad.mit.edu	37	5	52781807	52781807	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:52781807G>T	uc003jpd.2	+	6	1006	c.979G>T	c.(979-981)GAG>TAG	p.E327*	FST_uc003jpc.2_3'UTR	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	327	Asp/Glu-rich (highly acidic).				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				CGAGGAAGAGGAGGAAGATGA	0.438			NA											36	64					3.61848e-18	6.17376e-18	0.007835	1	0
DHX29	54505	broad.mit.edu	37	5	54567931	54567931	+	Nonsense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:54567931T>A	uc003jpx.2	-	18	2968	c.2848A>T	c.(2848-2850)AGA>TGA	p.R950*	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	950	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TCTTTTGTTCTTCCAGTATCA	0.308			NA											8	5					0	0	0.00308	0	0
PDE4D	5144	broad.mit.edu	37	5	58273027	58273027	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:58273027G>T	uc003jsa.2	-	12	1870	c.1698C>A	c.(1696-1698)GTC>GTA	p.V566V	PDE4D_uc003jrx.2_Silent_p.V430V|PDE4D_uc003jry.2_Silent_p.V264V|PDE4D_uc003jrz.2_Silent_p.V502V|PDE4D_uc003jsb.2_Silent_p.V505V|PDE4D_uc003jrt.2_Silent_p.V264V|PDE4D_uc003jru.2_Silent_p.V342V|PDE4D_uc003jrv.2_Silent_p.V436V|PDE4D_uc003jrw.2_Silent_p.V444V|PDE4D_uc003jrs.2_Silent_p.V275V	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	566					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	CGATGTCAATGACCATTTTCC	0.338			NA											22	44					1.55469e-16	2.58778e-16	0.00333	1	0
PAM	5066	broad.mit.edu	37	5	102260668	102260668	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:102260668G>T	uc003knw.2	+	5	737	c.364G>T	c.(364-366)GAT>TAT	p.D122Y	PAM_uc003kns.2_Missense_Mutation_p.D122Y|PAM_uc003knt.2_Missense_Mutation_p.D122Y|PAM_uc003knu.2_Missense_Mutation_p.D122Y|PAM_uc003knv.2_Missense_Mutation_p.D122Y|PAM_uc011cuz.1_Missense_Mutation_p.D25Y	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	122	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	CAGGTTTTGTGATGAAGGAAC	0.438			NA											31	33					1.61788e-16	2.68421e-16	0.002445	1	0
TSLP	85480	broad.mit.edu	37	5	110407739	110407739	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:110407739C>A	uc003kpb.2	+	1	350	c.151C>A	c.(151-153)CTG>ATG	p.L51M	TSLP_uc003kpa.2_RNA|TSLP_uc010jbt.1_5'Flank	NM_033035	NP_149024	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin isoform 1	51						extracellular space	cytokine activity				0		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		TTCTAAAGACCTGATTACATA	0.358			NA											28	37					1.80694e-10	2.55069e-10	0.009535	1	0
APC	324	broad.mit.edu	37	5	112178228	112178228	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:112178228G>T	uc010jby.2	+	16	7317	c.6937G>T	c.(6937-6939)GCC>TCC	p.A2313S	APC_uc011cvt.1_Missense_Mutation_p.A2295S|APC_uc003kpz.3_Missense_Mutation_p.A2313S|APC_uc003kpy.3_Missense_Mutation_p.A2313S|APC_uc010jbz.2_Missense_Mutation_p.A2030S|APC_uc010jca.2_Missense_Mutation_p.A1613S	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2313	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTCAAGACCTGCCCAGCAACC	0.453	NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			17	23					1.01871e-10	1.44802e-10	0.008871	1	0
SEMA6A	57556	broad.mit.edu	37	5	115838024	115838024	+	Splice_Site	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:115838024C>A	uc010jck.2	-	3	810	c.101_splice	c.e3-1	p.Y34_splice	SEMA6A_uc003krx.3_Splice_Site_p.Y34_splice	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and						apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGTTTTGTATCTGTGAAAAGA	0.498			NA											35	45					6.84511e-11	9.75691e-11	0.003271	1	0
MEGF10	84466	broad.mit.edu	37	5	126734443	126734443	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:126734443G>T	uc003kuh.3	+	8	1097	c.735G>T	c.(733-735)GTG>GTT	p.V245V	MEGF10_uc010jdc.1_Silent_p.V245V|MEGF10_uc010jdd.1_Silent_p.V245V|MEGF10_uc003kui.3_Silent_p.V245V	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	245	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 4.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ATGGAGGAGTGTGTCATCACG	0.522			NA											22	37					5.35356e-11	7.68446e-11	0.00278	1	0
MEGF10	84466	broad.mit.edu	37	5	126771052	126771052	+	Splice_Site	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:126771052G>A	uc003kuh.3	+	17	2338	c.1976_splice	c.e17-1	p.V659_splice	MEGF10_uc003kui.3_Splice_Site_p.V659_splice	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor						cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CTTATTCACAGTGTGTCCCAG	0.343			NA											13	19					0	0	0.001855	0	0
FBN2	2201	broad.mit.edu	37	5	127648464	127648464	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:127648464G>T	uc003kuu.2	-	37	5180	c.4741C>A	c.(4741-4743)CTG>ATG	p.L1581M		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1581	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCAAACTTCAGGTAGCAGTTG	0.522			NA											80	93					6.71967e-41	1.28125e-40	0.00361	1	0
FBN2	2201	broad.mit.edu	37	5	127712525	127712525	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:127712525G>C	uc003kuu.2	-	14	2310	c.1871C>G	c.(1870-1872)ACC>AGC	p.T624S	FBN2_uc003kuv.2_Missense_Mutation_p.T591S	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	624	EGF-like 9; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACACATGTTGGTAGTTGTACA	0.438			NA											41	53					0	0	0.002522	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128844829	128844829	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:128844829G>T	uc003kvb.1	+	3	789	c.789G>T	c.(787-789)ATG>ATT	p.M263I	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	263					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ATGATACAATGGCCATAACAG	0.383			NA											21	23					1.36565e-18	2.33784e-18	0.00278	1	0
CHSY3	337876	broad.mit.edu	37	5	129520233	129520233	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:129520233G>C	uc003kvd.2	+	3	1398	c.1398G>C	c.(1396-1398)TGG>TGC	p.W466C		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	466	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		TGATAGAATGGGAGTTCCTGA	0.502			NA											14	19					0	0	0.001855	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181958	140181958	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:140181958C>T	uc003lhf.2	+	1	1176	c.1176C>T	c.(1174-1176)CAC>CAT	p.H392H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.H392H	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	392	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACGCCCCACGTCCCCTTCA	0.567			NA											54	63					0	0	0.00361	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745167	140745167	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:140745167G>C	uc003lju.1	+	1	1270	c.1270G>C	c.(1270-1272)GTC>CTC	p.V424L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.V424L	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	424	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTTTAACCGTCATGGACCA	0.438			NA											36	38					0	0	0.002836	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140746231	140746231	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:140746231G>T	uc003lju.1	+	1	2334	c.2334G>T	c.(2332-2334)ACG>ACT	p.T778T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.T778T	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	778	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCAGACACGCTCCTTAGTG	0.522			NA											16	107					4.14922e-12	6.17249e-12	0.004007	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140754620	140754620	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:140754620G>T	uc003ljy.1	+	1	970	c.970G>T	c.(970-972)GGG>TGG	p.G324W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.G324W	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	324	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCCGGGATGGGCCAGGTCT	0.408			NA											56	77					3.63617e-18	6.19361e-18	0.00361	1	0
SPINK13	153218	broad.mit.edu	37	5	147661755	147661755	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:147661755A>C	uc003lpc.2	+	4	259	c.197A>C	c.(196-198)CAC>CCC	p.H66P	uc003lpb.1_Intron|SPINK13_uc010jgt.2_RNA	NM_001040129	NP_001035218	Q1W4C9	ISK13_HUMAN	serine PI Kazal type 5-like 3 precursor	66	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity				0						TCAAATGGCCACACTTTCCAG	0.279			NA											3	77					0	0	0.004672	0	0
CYFIP2	26999	broad.mit.edu	37	5	156751011	156751011	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:156751011G>T	uc003lwq.2	+	18	1892	c.1754G>T	c.(1753-1755)GGA>GTA	p.G585V	CYFIP2_uc011ddn.1_Missense_Mutation_p.G559V|CYFIP2_uc011ddo.1_Missense_Mutation_p.G389V|CYFIP2_uc003lwr.2_Missense_Mutation_p.G585V|CYFIP2_uc003lws.2_Missense_Mutation_p.G585V|CYFIP2_uc003lwt.2_Missense_Mutation_p.G488V|CYFIP2_uc011ddp.1_Missense_Mutation_p.G319V	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	610					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGCCTGGATGGACCCATTGTC	0.502			NA											9	11					3.86212e-05	4.42498e-05	0.008291	1	0
WWC1	23286	broad.mit.edu	37	5	167850650	167850650	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:167850650A>G	uc003lzu.2	+	11	1480	c.1387A>G	c.(1387-1389)ACT>GCT	p.T463A	WWC1_uc003lzv.2_Missense_Mutation_p.T463A|WWC1_uc011den.1_Missense_Mutation_p.T463A|WWC1_uc003lzw.2_Missense_Mutation_p.T262A	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	463					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		AGCCAGCTTCACTGACCTCTA	0.642			NA											35	38					0	0	0.004878	0	0
GABRP	2568	broad.mit.edu	37	5	170235647	170235647	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:170235647T>C	uc003mau.2	+	8	921	c.723T>C	c.(721-723)AAT>AAC	p.N241N	GABRP_uc011dev.1_Silent_p.N241N	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	241	Extracellular (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTCGGAGGAATGTTCTGTATT	0.418			NA											6	39					0	0	0.001168	0	0
RNF44	22838	broad.mit.edu	37	5	175959138	175959138	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:175959138G>A	uc003mek.1	-	3	689	c.164C>T	c.(163-165)TCC>TTC	p.S55F	RNF44_uc011dfo.1_Intron|RNF44_uc003mel.1_5'Flank	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	55	Pro-rich.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGCTGCTGGGAGGGTAAGCG	0.741			NA											12	8					0	0	0.001368	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179290820	179290820	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:179290820C>G	uc003mlh.2	-	22	3418	c.3381G>C	c.(3379-3381)GTG>GTC	p.V1127V	TBC1D9B_uc003mli.2_Silent_p.V1110V|TBC1D9B_uc003mlj.2_Silent_p.V1109V|TBC1D9B_uc003mlf.2_Silent_p.V201V|TBC1D9B_uc003mlg.2_Silent_p.V286V|TBC1D9B_uc011dgv.1_Silent_p.V286V	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	1127						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCCTCCACCACCACCTGGC	0.637			NA											37	50					0	0	0.009718	0	0
BTNL8	79908	broad.mit.edu	37	5	180338529	180338529	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:180338529C>A	uc003mmp.2	+	3	822	c.588C>A	c.(586-588)ACC>ACA	p.T196T	BTNL8_uc003mmq.2_Silent_p.T196T|BTNL8_uc011dhg.1_Silent_p.T71T|BTNL8_uc010jll.2_Silent_p.T196T|BTNL8_uc010jlm.2_Silent_p.T80T|BTNL8_uc011dhh.1_Silent_p.T12T	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	196	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCTCTGACCGTCCAAGAGA	0.547			NA											33	34					1.99505e-19	3.43835e-19	0.002445	1	0
RREB1	6239	broad.mit.edu	37	6	7230553	7230553	+	Missense_Mutation	SNP	G	G	C	rs142616407	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:7230553G>C	uc003mxc.2	+	10	2611	c.2221G>C	c.(2221-2223)GCG>CCG	p.A741P	RREB1_uc003mxb.2_Missense_Mutation_p.A741P|RREB1_uc010jnx.2_Missense_Mutation_p.A741P	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	741					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GAGTAGCAGCGCGGCCGAGCT	0.627			NA											13	30					0	0	0.004007	0	0
NUP153	9972	broad.mit.edu	37	6	17688816	17688816	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:17688816T>C	uc003ncd.1	-	2	345	c.145A>G	c.(145-147)AAT>GAT	p.N49D	NUP153_uc011dje.1_Missense_Mutation_p.N49D|NUP153_uc010jpl.1_Missense_Mutation_p.N49D	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	49					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GGCACAATATTCTTAACAGAT	0.368			NA											12	117					0	0	0.00245	0	0
OR2W1	26692	broad.mit.edu	37	6	29012594	29012594	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:29012594T>A	uc003nlw.2	-	1	359	c.359A>T	c.(358-360)TAT>TTT	p.Y120F		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AAAACGATCATAGGACATAAC	0.403			NA											17	24					0	0	0.004007	0	0
C6orf27	80737	broad.mit.edu	37	6	31735274	31735274	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:31735274C>G	uc011dog.1	-	12	1892	c.1654G>C	c.(1654-1656)GAG>CAG	p.E552Q	C6orf27_uc003nxd.2_Missense_Mutation_p.E227Q	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	552						extracellular region				ovary(3)	3						CCGCCTTCCTCCTGGCCCTGG	0.592			NA											53	151					0	0	0.00361	0	0
PBX2	5089	broad.mit.edu	37	6	32155933	32155934	+	Splice_Site	DNP	CC	CC	AA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:32155933_32155934CC>AA	uc003oav.1	-	4	815	c.544_splice	c.e4-1	p.A182_splice	PBX2_uc003oaw.2_Splice_Site_p.A182_splice	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2								transcription factor binding			ovary(1)	1						TCATTACATGCCTGTAGTGGGG	0.604			NA											11	21					0	0	0.004672	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188606	32188606	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:32188606G>T	uc003obb.2	-	5	988	c.849C>A	c.(847-849)CAC>CAA	p.H283Q	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.H283Q	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	283	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TCTGACACTGGTGGCTGACAC	0.557			NA											52	114					1.13205e-32	2.12675e-32	0.00361	1	0
FKBP5	2289	broad.mit.edu	37	6	35588009	35588009	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:35588009T>C	uc011dte.1	-	4	496	c.293A>G	c.(292-294)AAG>AGG	p.K98R	FKBP5_uc003okx.2_Missense_Mutation_p.K98R|FKBP5_uc011dtf.1_Intron|FKBP5_uc003oky.2_Missense_Mutation_p.K98R|FKBP5_uc003okz.2_Missense_Mutation_p.K98R	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	98	PPIase FKBP-type 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						CTCTCCTTTCTTCATGGTAGC	0.423			NA											38	38					0	0	0.004878	0	0
DNAH8	1769	broad.mit.edu	37	6	38835952	38835952	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:38835952G>A	uc003ooe.1	+	46	6757	c.6157G>A	c.(6157-6159)GAT>AAT	p.D2053N		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGGACTAAGAGATATGAACCT	0.363			NA											35	21					0	0	0.00623	0	0
KIAA0240	23506	broad.mit.edu	37	6	42832695	42832695	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:42832695G>T	uc003osn.1	+	13	2902	c.2751G>T	c.(2749-2751)ACG>ACT	p.T917T	KIAA0240_uc011duw.1_Silent_p.T917T|KIAA0240_uc003osp.1_Silent_p.T917T	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	917										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			ACCAGAGCACGTCTGAAGAGA	0.522			NA											25	13					3.28513e-13	5.05632e-13	0.003954	1	0
PKHD1	5314	broad.mit.edu	37	6	51890625	51890625	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:51890625A>T	uc003pah.1	-	32	4259	c.3983T>A	c.(3982-3984)GTC>GAC	p.V1328D	PKHD1_uc003pai.2_Missense_Mutation_p.V1328D	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1328	IPT/TIG 8; atypical.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAGAAGGATGACTGAGTTGGA	0.527			NA											18	28					0	0	0.00499	0	0
PKHD1	5314	broad.mit.edu	37	6	51944753	51944753	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:51944753C>A	uc003pah.1	-	5	611	c.335G>T	c.(334-336)GGG>GTG	p.G112V	PKHD1_uc003pai.2_Missense_Mutation_p.G112V	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	112	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAGCTGTCCCCCGAAGTATGC	0.463			NA											78	82					2.22156e-40	4.22799e-40	0.00361	1	0
EYS	346007	broad.mit.edu	37	6	66063473	66063473	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:66063473C>A	uc011dxu.1	-	9	1875	c.1337G>T	c.(1336-1338)TGG>TTG	p.W446L	EYS_uc003peq.2_Missense_Mutation_p.W446L|EYS_uc003per.1_Missense_Mutation_p.W446L	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	446					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CTTCAAAAACCAACATGGATT	0.333			NA											7	30					0.00198382	0.00213417	0.001984	1	0
BAI3	577	broad.mit.edu	37	6	70065732	70065732	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:70065732T>C	uc003pev.3	+	28	4023	c.3575T>C	c.(3574-3576)GTA>GCA	p.V1192A	BAI3_uc010kak.2_Missense_Mutation_p.V1192A|BAI3_uc011dxx.1_Missense_Mutation_p.V398A	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1192	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GAAAAGGATGTAGACATTGCC	0.289			NA											38	45					0	0	0.002852	0	0
SNAP91	9892	broad.mit.edu	37	6	84350818	84350818	+	Silent	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:84350818T>G	uc011dze.1	-	8	1079	c.762A>C	c.(760-762)GCA>GCC	p.A254A	SNAP91_uc003pkb.2_Silent_p.A219A|SNAP91_uc003pkc.2_Silent_p.A254A|SNAP91_uc003pkd.2_Silent_p.A254A|SNAP91_uc003pka.2_Silent_p.A254A|SNAP91_uc011dzf.1_Silent_p.A135A	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	254					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TACTTACCTCTGCAACCTTGA	0.299			NA											2	1					0	0	0.004672	0	0
MCHR2	84539	broad.mit.edu	37	6	100395640	100395640	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:100395640G>A	uc003pqh.1	-	3	705	c.390C>T	c.(388-390)GAC>GAT	p.D130D	MCHR2_uc003pqi.1_Silent_p.D130D	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	130	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		TCACTTACCTGTCCACACTCA	0.443			NA											60	94					0	0	0.00361	0	0
REV3L	5980	broad.mit.edu	37	6	111695587	111695587	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:111695587C>G	uc003puy.3	-	13	4294	c.3971G>C	c.(3970-3972)TGT>TCT	p.C1324S	REV3L_uc003pux.3_Missense_Mutation_p.C1246S|REV3L_uc003puz.3_Missense_Mutation_p.C1246S	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1324					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TATAGAATTACAAACAACTGA	0.348			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					12	123					0	0	0.000978	0	0
LAMA4	3910	broad.mit.edu	37	6	112439054	112439054	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:112439054G>T	uc003pvu.2	-	35	5178	c.4869C>A	c.(4867-4869)CTC>CTA	p.L1623L	LAMA4_uc003pvv.2_Silent_p.L1616L|LAMA4_uc003pvt.2_Silent_p.L1616L	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1623	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		AGGCCCCATTGAGCTGGAGAT	0.433			NA											13	94					7.03913e-09	9.30658e-09	0.001368	1	0
GJA1	2697	broad.mit.edu	37	6	121769099	121769099	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:121769099G>A	uc003pyr.2	+	2	1356	c.1106G>A	c.(1105-1107)AGT>AAT	p.S369N	GJA1_uc011ebo.1_Missense_Mutation_p.S270N|GJA1_uc011ebp.1_Missense_Mutation_p.S157N	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	369	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	AGAGCCAGCAGTCGTGCCAGC	0.483			NA											16	45					0	0	0.006122	0	0
TRMT11	60487	broad.mit.edu	37	6	126319418	126319418	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:126319418T>C	uc003qam.2	+	5	465	c.344T>C	c.(343-345)TTT>TCT	p.F115S	TRMT11_uc003qan.2_RNA|TRMT11_uc010kev.2_Missense_Mutation_p.F115S	NM_001031712	NP_001026882	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11	115					tRNA processing		methyltransferase activity|nucleic acid binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0356)		ATTCACACTTTTAATAAGACA	0.294			NA											3	19					0	0	0.004672	0	0
EPB41L2	2037	broad.mit.edu	37	6	131247753	131247753	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:131247753C>A	uc003qch.2	-	4	984	c.802G>T	c.(802-804)GAG>TAG	p.E268*	EPB41L2_uc003qcg.1_Nonsense_Mutation_p.E268*|EPB41L2_uc011eby.1_Nonsense_Mutation_p.E268*|EPB41L2_uc003qci.2_Nonsense_Mutation_p.E268*|EPB41L2_uc010kfk.2_Nonsense_Mutation_p.E268*|EPB41L2_uc010kfl.1_Nonsense_Mutation_p.E268*	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	268	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		ACTTTCTGCTCAGGGCTTTCC	0.313			NA											15	85					3.45872e-05	4.03057e-05	0.004007	1	0
VNN1	8876	broad.mit.edu	37	6	133004338	133004338	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:133004338G>T	uc003qdo.2	-	7	1503	c.1483C>A	c.(1483-1485)CAA>AAA	p.Q495K	VNN1_uc003qdn.2_RNA	NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	495					acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		ATTCTTGCTTGTGCTGTGAGG	0.368			NA											16	58					6.49762e-13	9.94097e-13	0.006122	1	0
ALDH8A1	64577	broad.mit.edu	37	6	135250221	135250221	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:135250221C>A	uc003qew.2	-	6	1035	c.982G>T	c.(982-984)GCT>TCT	p.A328S	ALDH8A1_uc003qex.2_Intron|ALDH8A1_uc010kgh.2_Intron|ALDH8A1_uc011ecx.1_Missense_Mutation_p.A278S	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	328					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		CTTATCAGAGCACCTATGCTC	0.388			NA											11	54					6.40141e-05	7.26916e-05	0.000978	1	0
KIAA1244	57221	broad.mit.edu	37	6	138584671	138584671	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:138584671T>A	uc003qhu.2	+	12	2051	c.2051T>A	c.(2050-2052)CTC>CAC	p.L684H		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	684	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GAAGGCCTCCTCCCTCGGCTC	0.557			NA											7	53					0	0	0.00308	0	0
TXLNB	167838	broad.mit.edu	37	6	139569031	139569031	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:139569031C>A	uc011eds.1	-	8	1258	c.1093G>T	c.(1093-1095)GGA>TGA	p.G365*		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	365						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TCAAACCTTCCTGAGTAGAGA	0.378			NA											29	52					1.88708e-17	3.19305e-17	0.008361	1	0
AIG1	51390	broad.mit.edu	37	6	143605319	143605319	+	Nonsense_Mutation	SNP	G	G	T	rs115165047	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:143605319G>T	uc003qjh.2	+	4	512	c.472G>T	c.(472-474)GGA>TGA	p.G158*	AIG1_uc003qjf.2_Nonsense_Mutation_p.G148*|AIG1_uc003qji.2_Nonsense_Mutation_p.G96*	NM_016108	NP_057192	Q9NVV5	AIG1_HUMAN	androgen-induced 1	158						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)		CAGGAGCAGCGGACTTACCGC	0.443			NA											10	27					3.07112e-06	3.68823e-06	0.000978	1	0
SF3B5	83443	broad.mit.edu	37	6	144416564	144416564	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:144416564G>A	uc003qkr.1	-	1	191	c.71C>T	c.(70-72)GCC>GTC	p.A24V		NM_031287	NP_112577	Q9BWJ5	SF3B5_HUMAN	SF3b10	24					nuclear mRNA splicing, via spliceosome	nucleoplasm|U12-type spliceosomal complex					0				OV - Ovarian serous cystadenocarcinoma(155;1.68e-06)|GBM - Glioblastoma multiforme(68;0.0638)		GGTGGTGTCGGCGTGGCCCGT	0.597			NA											3	30					0	0	0.004672	0	0
OPRM1	4988	broad.mit.edu	37	6	154410984	154410984	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:154410984C>A	uc003qpr.2	+	2	551	c.314C>A	c.(313-315)ACC>AAC	p.T105N	OPRM1_uc011efb.1_Missense_Mutation_p.T153N|OPRM1_uc011efc.1_Missense_Mutation_p.T24N|OPRM1_uc011efd.1_Missense_Mutation_p.T5N|OPRM1_uc011efe.1_Missense_Mutation_p.T198N|OPRM1_uc003qpn.2_Missense_Mutation_p.T105N|OPRM1_uc003qpo.1_Missense_Mutation_p.T105N|OPRM1_uc011eff.1_Missense_Mutation_p.T105N|OPRM1_uc011efg.1_Missense_Mutation_p.T105N|OPRM1_uc011efh.1_Missense_Mutation_p.T105N|OPRM1_uc003qpq.1_Missense_Mutation_p.T105N|OPRM1_uc003qpt.1_Missense_Mutation_p.T105N|OPRM1_uc011efi.1_Missense_Mutation_p.T105N|OPRM1_uc003qpp.2_RNA|OPRM1_uc003qps.2_RNA|OPRM1_uc010kjg.2_Missense_Mutation_p.T5N|OPRM1_uc003qpu.2_Missense_Mutation_p.T5N	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	105	Cytoplasmic (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	AAGACTGCCACCAACATCTAC	0.413			NA											27	43					2.79863e-10	3.91809e-10	0.004656	1	0
ARID1B	57492	broad.mit.edu	37	6	157222534	157222534	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:157222534G>T	uc003qqn.2	+	3	1740	c.1588G>T	c.(1588-1590)GGT>TGT	p.G530C	ARID1B_uc003qqo.2_Missense_Mutation_p.G543C|ARID1B_uc003qqp.2_Missense_Mutation_p.G530C	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	588	Gln-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TGGACAGCAAGGTGTGAGTGG	0.498			NA											3	32					2.56e-06	3.08893e-06	0.009096	1	0
FAM120B	84498	broad.mit.edu	37	6	170627610	170627610	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr6:170627610C>A	uc003qxp.2	+	2	1240	c.1132C>A	c.(1132-1134)CCC>ACC	p.P378T	FAM120B_uc003qxo.1_Missense_Mutation_p.P378T|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	378					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		GCAAGAAGTTCCCATGTGTTC	0.527			NA											69	129					1.26778e-28	2.33876e-28	0.00361	1	0
SUN1	23353	broad.mit.edu	37	7	883154	883154	+	Nonsense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:883154A>T	uc011jvp.1	+	6	734	c.655A>T	c.(655-657)AAA>TAA	p.K219*	SUN1_uc010ksa.1_Nonsense_Mutation_p.K240*|SUN1_uc003sje.1_Nonsense_Mutation_p.K219*|SUN1_uc003sjf.2_Nonsense_Mutation_p.K169*|SUN1_uc011jvq.1_Intron|SUN1_uc003sjg.2_Nonsense_Mutation_p.K30*	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	219	SYNE2-binding.|Nuclear.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						CAGGAATCAAAAATGTAAGTC	0.488			NA											19	321					0	0	0.003954	0	0
C7orf27	221927	broad.mit.edu	37	7	2593983	2593983	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:2593983C>A	uc003smi.2	-	2	125	c.83G>T	c.(82-84)TGT>TTT	p.C28F	C7orf27_uc003smj.1_Missense_Mutation_p.C28F	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	28					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		CTTCTCCAAACAGGTGTCATC	0.592			NA											26	87					3.65163e-15	5.90501e-15	0.00632	1	0
MMD2	221938	broad.mit.edu	37	7	4947150	4947150	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:4947150C>A	uc003sno.3	-	7	886	c.690G>T	c.(688-690)GGG>GGT	p.G230G	MMD2_uc003snl.1_RNA|MMD2_uc003snn.3_Silent_p.G206G|MMD2_uc010ksq.2_3'UTR	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	230	Cytoplasmic (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		AGGGGATCCTCCCGTCACTCT	0.582			NA											44	43					9.39024e-22	1.65462e-21	0.009718	1	0
THSD7A	221981	broad.mit.edu	37	7	11871417	11871417	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:11871417C>A	uc003ssf.3	-	1	408	c.156G>T	c.(154-156)GAG>GAT	p.E52D		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	52	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GCGCCTCCGCCTCGCCCTGCG	0.458			NA								HNSCC(18;0.044)			8	9					0.00307968	0.00329919	0.00308	1	0
MGC87042	256227	broad.mit.edu	37	7	22534440	22534440	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:22534440T>C	uc003svh.2	-	2	132	c.35A>G	c.(34-36)GAA>GGA	p.E12G	MGC87042_uc010kum.1_Missense_Mutation_p.E12G			Q6NZ63	STEAL_HUMAN	SubName: Full=cDNA FLJ60218, highly similar to Six transmembrane epithelial antigen ofprostate 1;	12						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0						TTTCCAAATTTCTTCTTGGTT	0.239			NA											22	30					0	0	0.003954	0	0
FAM126A	84668	broad.mit.edu	37	7	22999980	22999980	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:22999980C>T	uc003svm.3	-	10	1141	c.886G>A	c.(886-888)GAA>AAA	p.E296K	FAM126A_uc003svn.3_Missense_Mutation_p.E152K	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	296						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						CTTGTACCTTCCTTATTAGAT	0.383			NA											41	130					0	0	0.007835	0	0
C7orf46	340277	broad.mit.edu	37	7	23729051	23729051	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:23729051G>A	uc003swo.3	+	3	492	c.403G>A	c.(403-405)GCT>ACT	p.A135T	C7orf46_uc003swq.3_Missense_Mutation_p.A135T|C7orf46_uc003swr.3_Missense_Mutation_p.A77T|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	135											0						TCAGCACAGTGCTGCGCCTGG	0.428			NA											4	54					0	0	0.009096	0	0
INMT	11185	broad.mit.edu	37	7	30795407	30795407	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:30795407C>A	uc003tbs.1	+	3	748	c.732C>A	c.(730-732)GTC>GTA	p.V244V	FAM188B_uc010kwe.2_Intron|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Silent_p.V243V	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	244						cytoplasm	amine N-methyltransferase activity				0						GCTACTCTGTCACCAATGCTG	0.592			NA											33	96					8.4185e-14	1.32161e-13	0.002445	1	0
HERPUD2	64224	broad.mit.edu	37	7	35733802	35733802	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:35733802T>C	uc003tet.2	-	1	944	c.139A>G	c.(139-141)AGC>GGC	p.S47G	HERPUD2_uc003tes.3_Missense_Mutation_p.S47G|uc003teu.3_5'Flank	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	47	Ubiquitin-like.				response to unfolded protein	integral to membrane				ovary(3)	3						ACTGGTTTGCTAGGGTAAACG	0.478			NA											28	136					0	0	0.003271	0	0
PKD1L1	168507	broad.mit.edu	37	7	47852796	47852796	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:47852796C>T	uc003tny.1	-	49	7269	c.7269G>A	c.(7267-7269)GAG>GAA	p.E2423E	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_Silent_p.E150E	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2423	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CGTTTTGGTTCTCTGGGTCTA	0.562			NA											54	65					0	0	0.00361	0	0
ABCA13	154664	broad.mit.edu	37	7	48237881	48237881	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:48237881G>T	uc003toq.2	+	3	236	c.211G>T	c.(211-213)GTT>TTT	p.V71F	ABCA13_uc003top.2_Missense_Mutation_p.V71F|ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	71					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TATCCCCTTTGTTCAAAGCCT	0.423			NA											16	32					2.4624e-09	3.3288e-09	0.008871	1	0
ABCA13	154664	broad.mit.edu	37	7	48314899	48314899	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:48314899G>T	uc003toq.2	+	17	5661	c.5636G>T	c.(5635-5637)CGA>CTA	p.R1879L	ABCA13_uc010kyr.2_Missense_Mutation_p.R1382L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1879					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAAAGCTCCCGAATGGAAATA	0.403			NA											41	34					4.92203e-23	8.82511e-23	0.00623	1	0
POM121L12	285877	broad.mit.edu	37	7	53104043	53104043	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:53104043G>T	uc003tpz.2	+	1	695	c.679G>T	c.(679-681)GCT>TCT	p.A227S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	227											0						TGGAGCGGTTGCTTCCTTCGT	0.647			NA											21	63					1.55795e-14	2.48396e-14	0.001882	1	0
CALN1	83698	broad.mit.edu	37	7	71275385	71275385	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:71275385G>T	uc003twa.3	-	5	995	c.468C>A	c.(466-468)ATC>ATA	p.I156I	CALN1_uc003twb.3_Silent_p.I198I|CALN1_uc003twc.3_Silent_p.I156I	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	156	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CATTGATAATGATGTTCTCAA	0.507			NA											34	64					9.78485e-24	1.77307e-23	0.002836	1	0
PCLO	27445	broad.mit.edu	37	7	82544891	82544891	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:82544891C>A	uc003uhx.2	-	7	12700	c.12411G>T	c.(12409-12411)GAG>GAT	p.E4137D	PCLO_uc003uhv.2_Missense_Mutation_p.E4137D|PCLO_uc010lec.2_Missense_Mutation_p.E1102D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4068					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GATCTAAGCTCTCTGTCCCTC	0.413			NA											13	81					9.31168e-06	1.10145e-05	0.001855	1	0
COL1A2	1278	broad.mit.edu	37	7	94024365	94024365	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:94024365C>A	uc003ung.1	+	1	493	c.22C>A	c.(22-24)CGG>AGG	p.R8R	COL1A2_uc011kib.1_Silent_p.R8R	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	8					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGTGGATACGCGGACTTTGTT	0.552			NA								HNSCC(75;0.22)	OREG0018169	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	72					6.29468e-14	9.92773e-14	0.004878	1	0
TRRAP	8295	broad.mit.edu	37	7	98508005	98508005	+	Silent	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:98508005A>C	uc003upp.2	+	15	1886	c.1677A>C	c.(1675-1677)ACA>ACC	p.T559T	TRRAP_uc011kis.1_Silent_p.T559T|TRRAP_uc003upr.2_Silent_p.T251T	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	559					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GTGTCAAGACAATCACGTGGG	0.418			NA											7	333					0	0	0.004482	0	0
GATS	352954	broad.mit.edu	37	7	99821629	99821629	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:99821629C>A	uc003uua.3	-	3	536	c.287G>T	c.(286-288)GGT>GTT	p.G96V	GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc010lgt.2_RNA|GATS_uc011kjl.1_5'Flank|GATS_uc010lgu.2_RNA	NM_178831	NP_849153	Q8NAP1	GATS_HUMAN	GATS, stromal antigen 3 opposite strand	96											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAAGCTGCCACCGCCGGACAC	0.617			NA											151	46					1.73214e-63	3.3338e-63	0.00361	1	0
MUC17	140453	broad.mit.edu	37	7	100684607	100684607	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:100684607A>C	uc003uxp.1	+	3	9963	c.9910A>C	c.(9910-9912)ACT>CCT	p.T3304P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3304	Extracellular (Potential).|Ser-rich.|53.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTTTCAACAACTCCTGCTGA	0.493			NA											10	496					0	0	0.003163	0	0
LHFPL3	375612	broad.mit.edu	37	7	104377165	104377165	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:104377165G>A	uc003vce.2	+	2	613	c.489G>A	c.(487-489)TGG>TGA	p.W163*	LHFPL3_uc003vcf.2_Nonsense_Mutation_p.W163*	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	149						integral to membrane					0						CTGATGGCTGGGACTCAGATG	0.423			NA											18	19					0	0	0.007413	0	0
CDHR3	222256	broad.mit.edu	37	7	105662892	105662892	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:105662892A>T	uc003vdl.3	+	14	2182	c.2074A>T	c.(2074-2076)AGG>TGG	p.R692W	CDHR3_uc003vdk.2_Intron|CDHR3_uc003vdm.3_Missense_Mutation_p.R679W|CDHR3_uc011klt.1_Missense_Mutation_p.R604W|CDHR3_uc003vdn.2_Intron	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	692	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CACGACCCCCAGGGTAAGGGC	0.522			NA											310	108					0	0	0.00361	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117431569	117431569	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:117431569G>T	uc003vjf.2	-	4	1773	c.1681C>A	c.(1681-1683)CCC>ACC	p.P561T		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	561	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TTGAGTTGGGGGTGTGGTGGA	0.502			NA											158	411					2.01345e-68	3.88988e-68	0.00361	1	0
KCND2	3751	broad.mit.edu	37	7	119915119	119915119	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:119915119G>T	uc003vjj.1	+	1	1398	c.433G>T	c.(433-435)GCC>TCC	p.A145S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	145	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCGAGAGAACGCCGAGCGCCT	0.602			NA											364	95					2.86298e-183	5.55212e-183	0.00361	1	0
C7orf58	79974	broad.mit.edu	37	7	120704314	120704314	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:120704314A>C	uc003vjq.3	+	5	1010	c.563A>C	c.(562-564)CAG>CCG	p.Q188P	C7orf58_uc003vjr.1_Missense_Mutation_p.Q188P|C7orf58_uc003vjs.3_Missense_Mutation_p.Q188P|C7orf58_uc003vjt.3_5'UTR	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	188						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CCAGAAATACAGCAGCCACTT	0.388			NA											7	43					0	0	0.001984	0	0
AASS	10157	broad.mit.edu	37	7	121755132	121755132	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:121755132G>T	uc003vka.2	-	8	1135	c.1039C>A	c.(1039-1041)CAC>AAC	p.H347N	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.H347N|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	347	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCTTACTTGTGTGGTAATGCA	0.468			NA											16	50					3.41278e-10	4.76484e-10	0.00499	1	0
PAX4	5078	broad.mit.edu	37	7	127253908	127253908	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:127253908G>A	uc010lld.1	-	4	646	c.440C>T	c.(439-441)CCC>CTC	p.P147L	PAX4_uc003vmf.2_Missense_Mutation_p.P145L|PAX4_uc003vmg.1_Missense_Mutation_p.P147L|PAX4_uc003vmh.2_Missense_Mutation_p.P145L	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	155					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCACTATGGGGAGTGAGGAC	0.562	Ovarian(113;737 1605 7858 27720 34092)		NA											7	63					0	0	0.001984	0	0
METTL2B	55798	broad.mit.edu	37	7	128116825	128116825	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:128116825C>T	uc003vnf.2	+	1	43	c.6C>T	c.(4-6)GCC>GCT	p.A2A	METTL2B_uc003vng.2_5'UTR|METTL2B_uc011kop.1_5'Flank	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	2							methyltransferase activity			skin(1)	1						GTGTCATGGCCGGCTCCTACC	0.602			NA									OREG0018295	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	10					0	0	0.00278	0	0
CPA1	1357	broad.mit.edu	37	7	130025175	130025175	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:130025175C>A	uc003vpx.2	+	8	1048	c.976C>A	c.(976-978)CAG>AAG	p.Q326K	CPA1_uc003vpw.2_Missense_Mutation_p.Q160K	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	326					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AGTCCCTGACCAGGATGAGCT	0.572			NA											54	36					8.52529e-16	1.39406e-15	0.00361	1	0
PLXNA4	91584	broad.mit.edu	37	7	131830040	131830040	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:131830040A>C	uc003vra.3	-	29	5292	c.5063T>G	c.(5062-5064)CTG>CGG	p.L1688R	PLXNA4_uc003vqz.3_5'UTR	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1688	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AAACTTCTGCAGTGTGCCCTG	0.547			NA											7	33					0	0	0.00308	0	0
PLXNA4	91584	broad.mit.edu	37	7	131913111	131913111	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:131913111G>T	uc003vra.3	-	6	1951	c.1722C>A	c.(1720-1722)AAC>AAA	p.N574K		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	574	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TTACCAGCACGTTGTACTGAG	0.592			NA											11	40					0.000978159	0.00106576	0.000978	1	0
NUP205	23165	broad.mit.edu	37	7	135310997	135310997	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:135310997A>T	uc003vsw.2	+	33	4712	c.4681A>T	c.(4681-4683)ACA>TCA	p.T1561S	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1561					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GGCATTTCTCACAAGAGTGGC	0.448			NA											5	111					0	0	0.001168	0	0
CHRM2	1129	broad.mit.edu	37	7	136700192	136700192	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:136700192G>T	uc003vtf.1	+	4	1203	c.580G>T	c.(580-582)GCC>TCC	p.A194S	CHRM2_uc003vtg.1_Missense_Mutation_p.A194S|CHRM2_uc003vtj.1_Missense_Mutation_p.A194S|CHRM2_uc003vtk.1_Missense_Mutation_p.A194S|CHRM2_uc003vtl.1_Missense_Mutation_p.A194S|CHRM2_uc003vtm.1_Missense_Mutation_p.A194S|CHRM2_uc003vti.1_Missense_Mutation_p.A194S|CHRM2_uc003vto.1_Missense_Mutation_p.A194S|CHRM2_uc003vtn.1_Missense_Mutation_p.A194S|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	194	Helical; Name=5; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GGCTATTGCAGCCTTCTATTT	0.478			NA											27	38					2.08973e-25	3.80018e-25	0.005443	1	0
DGKI	9162	broad.mit.edu	37	7	137363342	137363342	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:137363342G>T	uc003vtt.2	-	3	568	c.567C>A	c.(565-567)CTC>CTA	p.L189L	DGKI_uc003vtu.2_Translation_Start_Site	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	189	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CAAGGTAGCAGAGGTCTCCCG	0.522			NA											47	164					6.81593e-30	1.26194e-29	0.00361	1	0
CREB3L2	64764	broad.mit.edu	37	7	137612987	137612987	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:137612987G>A	uc003vtw.2	-	2	623	c.228C>T	c.(226-228)CTC>CTT	p.L76L	CREB3L2_uc003vtx.1_Silent_p.L76L|CREB3L2_uc003vty.3_Silent_p.L76L|CREB3L2_uc003vtv.2_Silent_p.L13L	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	76	Cytoplasmic (Potential).				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						CAGCCTGGATGAGAGGCGCCG	0.572			NA	T	FUS	fibromyxoid sarcoma								5	12					0	0	0.000602	0	0
PRSS37	136242	broad.mit.edu	37	7	141536247	141536247	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:141536247G>T	uc003vws.1	-	5	1028	c.656C>A	c.(655-657)ACC>AAC	p.T219N	PRSS37_uc011krk.1_Missense_Mutation_p.T206N|PRSS37_uc011krl.1_Missense_Mutation_p.T218N|PRSS37_uc003vwt.1_Missense_Mutation_p.T206N	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	219	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			skin(1)	1						GTAAACATTGGTGTAGATGCC	0.517			NA											21	43					2.21704e-12	3.33698e-12	0.00278	1	0
MGAM	8972	broad.mit.edu	37	7	141750516	141750516	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:141750516T>C	uc003vwy.2	+	24	2711	c.2657T>C	c.(2656-2658)ATT>ACT	p.I886T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	886	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAGGTGAATATTTCACAATCA	0.363			NA											19	30					0	0	0.010504	0	0
OR2A12	346525	broad.mit.edu	37	7	143793025	143793025	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:143793025G>T	uc011kty.1	+	1	825	c.825G>T	c.(823-825)CTG>CTT	p.L275L		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TCCTTTCCCTGTTTTACAGCC	0.512			NA											10	352					1.58986e-06	1.93433e-06	0.008291	1	0
ARHGEF5	7984	broad.mit.edu	37	7	144070359	144070359	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:144070359G>C	uc003wel.2	+	10	4240	c.4122G>C	c.(4120-4122)AAG>AAC	p.K1374N	ARHGEF5_uc003wek.2_Missense_Mutation_p.K1374N|ARHGEF5_uc003wem.2_Missense_Mutation_p.K229N	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1374					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					TGAGCCAGAAGATTGAGTTTG	0.532			NA											24	60					0	0	0.009535	0	0
TPK1	27010	broad.mit.edu	37	7	144320281	144320281	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:144320281T>A	uc003weq.2	-	6	435	c.332A>T	c.(331-333)AAG>ATG	p.K111M	TPK1_uc003weo.2_Missense_Mutation_p.K106M|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Missense_Mutation_p.K111M|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	111					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	TTCTTCTATCTTCTTTTGGAG	0.323	Ovarian(45;88 1034 2073 5829 28455)		NA											31	115					0	0	0.008361	0	0
EZH2	2146	broad.mit.edu	37	7	148508784	148508784	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:148508784G>T	uc003wfd.1	-	16	2031	c.1865C>A	c.(1864-1866)GCA>GAA	p.A622E	EZH2_uc011kug.1_Missense_Mutation_p.A571E|EZH2_uc003wfb.1_Missense_Mutation_p.A627E|EZH2_uc003wfc.1_Missense_Mutation_p.A583E|EZH2_uc011kuh.1_Missense_Mutation_p.A613E	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	622	SET.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			CCCCCAGCCTGCCACGTCAGA	0.428			NA	Mis		DLBCL								10	38					0.00621372	0.00657393	0.006214	1	0
ZNF398	57541	broad.mit.edu	37	7	148851299	148851299	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:148851299G>T	uc003wfl.2	+	2	562	c.287G>T	c.(286-288)TGG>TTG	p.W96L	ZNF398_uc011kul.1_5'UTR|ZNF398_uc011kum.1_Missense_Mutation_p.W101L	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	96					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			GAGGGCAAGTGGGCCGTGCTG	0.597			NA											24	52					1.66031e-10	2.34693e-10	0.003954	1	0
ABP1	26	broad.mit.edu	37	7	150553925	150553925	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:150553925T>G	uc003why.1	+	3	4585	c.367T>G	c.(367-369)TGC>GGC	p.C123G	ABP1_uc003whz.1_Missense_Mutation_p.C123G|ABP1_uc003wia.1_Missense_Mutation_p.C123G	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	123					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	GCCAGGGCCCTGCTACATGCG	0.622	Pancreas(195;1227 3054 24912 28503)		NA											4	84					0	0	0.000602	0	0
RHEB	6009	broad.mit.edu	37	7	151174501	151174502	+	Splice_Site	DNP	CC	CC	GA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:151174501_151174502CC>GA	uc003wkh.1	-	4	606	c.193_splice	c.e4-1	p.D65_splice		NM_005614	NP_005605	Q15382	RHEB_HUMAN	Ras homolog enriched in brain precursor						cell cycle arrest|insulin receptor signaling pathway|positive regulation of TOR signaling cascade|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|metal ion binding|protein binding			large_intestine(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00306)	UCEC - Uterine corpus endometrioid carcinoma (81;0.174)		GAATATTCATCCTGTGGGGAAA	0.332	Pancreas(98;671 892 8111 15140 36556 39178 39939 44184)		NA											29	89					0	0	0.004672	0	0
DPP6	1804	broad.mit.edu	37	7	154143394	154143394	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:154143394G>T	uc003wlk.2	+	2	468	c.339G>T	c.(337-339)TCG>TCT	p.S113S	DPP6_uc003wli.2_Silent_p.S49S|DPP6_uc003wlj.2_Silent_p.S113S|DPP6_uc010lqh.1_Silent_p.S51S|DPP6_uc003wlm.2_Silent_p.S51S|DPP6_uc011kvq.1_Silent_p.S51S	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	113	Helical; Signal-anchor for type II membrane protein; (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TCGTCACCTCGGTCATACTTC	0.433	NSCLC(125;1384 1783 2490 7422 34254)		NA											23	57					1.64293e-13	2.55567e-13	0.00333	1	0
DPP6	1804	broad.mit.edu	37	7	154684101	154684101	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:154684101C>A	uc003wlk.2	+	26	2638	c.2509C>A	c.(2509-2511)CGG>AGG	p.R837R	DPP6_uc003wli.2_Silent_p.R773R|DPP6_uc003wlm.2_Silent_p.R775R|DPP6_uc011kvq.1_Silent_p.R730R	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	837	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GCATCTGTACCGGTCCATCAT	0.512	NSCLC(125;1384 1783 2490 7422 34254)		NA											18	53					5.03518e-11	7.25805e-11	0.007413	1	0
RBM33	155435	broad.mit.edu	37	7	155504087	155504087	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:155504087A>G	uc010lqk.1	+	8	1507	c.1139A>G	c.(1138-1140)CAG>CGG	p.Q380R	RBM33_uc011kvv.1_Missense_Mutation_p.Q189R	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	380	Pro-rich.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		GTGACTCCACAGCAGCCCAAG	0.542			NA											13	23					0	0	0.001368	0	0
CSMD1	64478	broad.mit.edu	37	8	3443692	3443692	+	Silent	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:3443692G>C	uc011kwk.1	-	9	1581	c.1191C>G	c.(1189-1191)CTC>CTG	p.L397L		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	397	Extracellular (Potential).|Sushi 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCAAGCAGCGAGCGTCTCTG	0.478			NA											6	8					0	0	0.001984	0	0
CSMD1	64478	broad.mit.edu	37	8	3565937	3565937	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:3565937G>T	uc011kwk.1	-	7	1398	c.1008C>A	c.(1006-1008)GTC>GTA	p.V336V		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	336	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGGACTCACAGACAGAGTTTT	0.478			NA											7	36					1.26484e-09	1.72127e-09	0.00308	1	0
RP1L1	94137	broad.mit.edu	37	8	10465982	10465982	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:10465982C>A	uc003wtc.2	-	4	5855	c.5626G>T	c.(5626-5628)GCC>TCC	p.A1876S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1876					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCTGGGGCCTCTACATCT	0.622			NA											57	163					1.3268e-25	2.4171e-25	0.00361	1	0
RP1L1	94137	broad.mit.edu	37	8	10467184	10467184	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:10467184G>A	uc003wtc.2	-	4	4653	c.4424C>T	c.(4423-4425)CCT>CTT	p.P1475L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1475					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TTCCAAACCAGGCTCAAGCTG	0.657			NA											10	63					0	0	0.001368	0	0
RP1L1	94137	broad.mit.edu	37	8	10468596	10468597	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:10468596_10468597CC>AA	uc003wtc.2	-	4	3240_3241	c.3011_3012GG>TT	c.(3010-3012)GGG>GTT	p.G1004V		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1004					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GAGCTGGCTCCCCCAGGCCTTC	0.658			NA											21	38					0	0	0.004672	0	0
DEFB136	613210	broad.mit.edu	37	8	11832107	11832107	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:11832107A>T	uc011kxm.1	-	1	2	c.2T>A	c.(1-3)ATG>AAG	p.M1K		NM_001033018	NP_001028190	Q30KP8	DB136_HUMAN	beta-defensin 136 precursor	1					defense response to bacterium	extracellular region					0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.163)		ACAGAGGTTCATGGCCGAAGA	0.542			NA											37	97					0	0	0.003271	0	0
MTMR7	9108	broad.mit.edu	37	8	17157479	17157479	+	Silent	SNP	G	G	C	rs146319076	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:17157479G>C	uc003wxm.2	-	14	2114	c.1875C>G	c.(1873-1875)TCC>TCG	p.S625S	MTMR7_uc011kya.1_Silent_p.S259S|MTMR7_uc011kyb.1_Silent_p.S216S	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	625							protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		CCTCCACCCCGGACTCTTGGT	0.512			NA											9	29					0	0	0.008291	0	0
SH2D4A	63898	broad.mit.edu	37	8	19221651	19221651	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:19221651A>T	uc003wzb.2	+	7	1111	c.775A>T	c.(775-777)AGG>TGG	p.R259W	SH2D4A_uc011kym.1_Missense_Mutation_p.R214W|SH2D4A_uc003wzc.2_Missense_Mutation_p.R259W	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	259						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		AGACTACAAGAGGTTATCCCT	0.547			NA											10	35					0	0	0.006214	0	0
WRN	7486	broad.mit.edu	37	8	30921859	30921859	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:30921859A>T	uc003xio.3	+	4	1052	c.264A>T	c.(262-264)TTA>TTT	p.L88F		NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	88	Interaction with WRNIP1 (By similarity).|3'-5' exonuclease.			L->A: No effect on exonuclease activity.	base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GGCCACCATTATACAATAGAG	0.353	Ovarian(18;161 598 2706 14834 27543)		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				37	112					0	0	0.00874	0	0
ADAM2	2515	broad.mit.edu	37	8	39607214	39607214	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:39607214C>A	uc003xnj.2	-	17	1922	c.1847G>T	c.(1846-1848)TGT>TTT	p.C616F	ADAM2_uc003xnk.2_Missense_Mutation_p.C597F|ADAM2_uc011lck.1_Missense_Mutation_p.C553F|ADAM2_uc003xnl.2_Missense_Mutation_p.C460F	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	616	Extracellular (Potential).|EGF-like.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		GTCAGTAGTACAATCATAACC	0.348			NA											11	33					2.68362e-12	4.01561e-12	0.001368	1	0
AP3M2	10947	broad.mit.edu	37	8	42012412	42012412	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:42012412G>T	uc003xop.2	+	3	498	c.207G>T	c.(205-207)GTG>GTT	p.V69V	AP3M2_uc003xoo.2_Silent_p.V69V|AP3M2_uc010lxe.2_RNA|AP3M2_uc003xoq.1_5'UTR|AP3M2_uc003xor.1_Silent_p.V69V	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	69					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			TTGTGGCCGTGATCCAGACGG	0.473			NA											9	46					0.000274275	0.00030271	0.004482	1	0
MCM4	4173	broad.mit.edu	37	8	48878870	48878870	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:48878870G>T	uc003xqk.1	+	9	1051	c.956G>T	c.(955-957)CGC>CTC	p.R319L	MCM4_uc003xql.1_Missense_Mutation_p.R319L|MCM4_uc011ldi.1_Missense_Mutation_p.R306L	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	319					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GAGATGGACCGCGGCCGCATT	0.622			NA											7	28					1.6384e-10	2.32239e-10	0.001984	1	0
SNAI2	6591	broad.mit.edu	37	8	49832627	49832627	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:49832627G>C	uc003xqp.2	-	2	617	c.453C>G	c.(451-453)TGC>TGG	p.C151W		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	151					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				ACTGGGCATCGCAGTGCAGCT	0.453			NA											11	90					0	0	0.001368	0	0
PXDNL	137902	broad.mit.edu	37	8	52370125	52370125	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:52370125G>T	uc003xqu.3	-	9	1016	c.915C>A	c.(913-915)TGC>TGA	p.C305*		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	305	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTCTGGCCATGCACTGATAGA	0.428			NA											19	86					8.28177e-16	1.35641e-15	0.007413	1	0
RP1	6101	broad.mit.edu	37	8	55534687	55534687	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:55534687T>G	uc003xsd.1	+	3	774	c.626T>G	c.(625-627)CTC>CGC	p.L209R	RP1_uc011ldy.1_Missense_Mutation_p.L209R	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	209	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTTCCCAGCCTCCAGGCAGTG	0.428	Colon(91;1014 1389 7634 14542 40420)		NA											8	31					0	0	0.006214	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66963823	66963823	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:66963823C>A	uc003xvs.1	+	3	332	c.41C>A	c.(40-42)TCA>TAA	p.S14*	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	14					protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CGGACTCTGTCAACAACAGGA	0.403			NA											31	101					6.38683e-12	9.45992e-12	0.008361	1	0
CSPP1	79848	broad.mit.edu	37	8	68024301	68024301	+	Splice_Site	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:68024301G>T	uc003xxi.2	+	11	1350	c.1319_splice	c.e11+1	p.R440_splice	CSPP1_uc003xxg.1_Splice_Site_p.R432_splice|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Splice_Site_p.R405_splice|CSPP1_uc003xxk.2_Splice_Site_p.R111_splice	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1							centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			ACAAGAGACGGTAATGAAAGG	0.353			NA											19	45					7.45023e-12	1.10031e-11	0.010504	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768313	77768313	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:77768313G>T	uc003yav.2	+	10	9408	c.9021G>T	c.(9019-9021)CCG>CCT	p.P3007P	ZFHX4_uc003yau.1_Silent_p.P3052P|ZFHX4_uc003yaw.1_Silent_p.P3007P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3007						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTGGCTCCGACCACGGTTC	0.507			NA								HNSCC(33;0.089)			17	83					1.00905e-13	1.58167e-13	0.008871	1	0
ZFAND1	79752	broad.mit.edu	37	8	82627319	82627319	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:82627319C>A	uc003ycj.1	-	4	183	c.169G>T	c.(169-171)GAT>TAT	p.D57Y	ZFAND1_uc010lzx.1_Missense_Mutation_p.D57Y|ZFAND1_uc003yck.1_5'UTR	NM_024699	NP_078975	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	57	AN1-type 1.						zinc ion binding			ovary(1)	1						GTATGTTGATCTGTCTTCAGT	0.368			NA											10	40					6.40141e-05	7.26916e-05	0.000978	1	0
CA3	761	broad.mit.edu	37	8	86356318	86356318	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:86356318A>C	uc003ydj.2	+	4	490	c.407A>C	c.(406-408)CAG>CCG	p.Q136P	CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	136					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						GCCCTGAAGCAGCGCGATGGG	0.378			NA											8	45					0	0	0.00308	0	0
NECAB1	64168	broad.mit.edu	37	8	91963412	91963412	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:91963412C>T	uc011lgg.1	+	12	1204	c.1010C>T	c.(1009-1011)ACA>ATA	p.T337I	NECAB1_uc003yer.2_Missense_Mutation_p.T86I	NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	337					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			CCAGAACTCACATCTACAATG	0.343			NA											6	29					0	0	0.00308	0	0
CDH17	1015	broad.mit.edu	37	8	95158253	95158253	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:95158253A>G	uc003ygh.2	-	15	2195	c.2070T>C	c.(2068-2070)GCT>GCC	p.A690A	CDH17_uc011lgo.1_Silent_p.A476A|CDH17_uc011lgp.1_Silent_p.A690A	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	690	Cadherin 7.|Extracellular (Potential).					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CATCATCAGTAGCCTCGAAAA	0.483			NA											12	53					0	0	0.001368	0	0
C8orf37	157657	broad.mit.edu	37	8	96259924	96259924	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:96259924T>A	uc003yho.1	-	6	565	c.545A>T	c.(544-546)CAG>CTG	p.Q182L		NM_177965	NP_808880	Q96NL8	CH037_HUMAN	hypothetical protein LOC157657	182											0	Breast(36;3.41e-05)					CCAGCTACACTGGCAGGCATA	0.403			NA											9	49					0	0	0.004482	0	0
GDF6	392255	broad.mit.edu	37	8	97156857	97156857	+	Missense_Mutation	SNP	G	G	T	rs138730867	by1000genomes	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:97156857G>T	uc003yhp.2	-	2	1402	c.1302C>A	c.(1300-1302)GAC>GAA	p.D434E		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	434					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					TATTGCCCGCGTCGATGTATA	0.602			NA											9	23					1.58986e-06	1.93433e-06	0.008291	1	0
UBR5	51366	broad.mit.edu	37	8	103359295	103359295	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:103359295C>A	uc003ykr.1	-	6	445	c.412G>T	c.(412-414)GGA>TGA	p.G138*	UBR5_uc003yks.1_Nonsense_Mutation_p.G138*	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	138					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CCACCACTTCCACCCACTCCA	0.453	Ovarian(131;96 1741 5634 7352 27489)		NA											60	87					4.49795e-14	7.12698e-14	0.00361	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110408305	110408305	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:110408305G>T	uc003yne.2	+	11	965	c.861G>T	c.(859-861)ACG>ACT	p.T287T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	287	Extracellular (Potential).|IPT/TIG 3.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGGCACCACGCTGACAATAA	0.393			NA								HNSCC(38;0.096)			4	17					5.9392e-07	7.33962e-07	0.001168	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110453508	110453508	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:110453508C>A	uc003yne.2	+	34	4208	c.4104C>A	c.(4102-4104)TCC>TCA	p.S1368S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1368	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCTAGGGTCCATCCCTTGCA	0.303			NA								HNSCC(38;0.096)			3	11					0.00024832	0.000275552	0.009096	1	0
CSMD3	114788	broad.mit.edu	37	8	113326281	113326281	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:113326281C>A	uc003ynu.2	-	49	7709	c.7550G>T	c.(7549-7551)GGA>GTA	p.G2517V	CSMD3_uc003yns.2_Missense_Mutation_p.G1719V|CSMD3_uc003ynt.2_Missense_Mutation_p.G2477V|CSMD3_uc011lhx.1_Missense_Mutation_p.G2413V|CSMD3_uc003ynw.1_Missense_Mutation_p.G228V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2517	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATATTTGGTCCTTTGGGAAG	0.284			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	15					0.000673444	0.000736895	0.008291	1	0
CSMD3	114788	broad.mit.edu	37	8	113516078	113516078	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:113516078T>A	uc003ynu.2	-	30	5183	c.5024A>T	c.(5023-5025)CAT>CTT	p.H1675L	CSMD3_uc003yns.2_Missense_Mutation_p.H947L|CSMD3_uc003ynt.2_Missense_Mutation_p.H1635L|CSMD3_uc011lhx.1_Missense_Mutation_p.H1571L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1675	Extracellular (Potential).|CUB 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAAAGCCAAATGCATTGTATT	0.353			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	74					0	0	0.008291	0	0
CSMD3	114788	broad.mit.edu	37	8	113563004	113563004	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:113563004C>A	uc003ynu.2	-	27	4619	c.4460G>T	c.(4459-4461)GGA>GTA	p.G1487V	CSMD3_uc003yns.2_Missense_Mutation_p.G759V|CSMD3_uc003ynt.2_Missense_Mutation_p.G1447V|CSMD3_uc011lhx.1_Missense_Mutation_p.G1383V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1487	Extracellular (Potential).|CUB 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATAAGAGATCCACTAATTTC	0.378			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	35					1.74807e-11	2.54854e-11	0.002096	1	0
TRPS1	7227	broad.mit.edu	37	8	116599310	116599310	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:116599310C>A	uc003ynz.2	-	4	3038	c.2579G>T	c.(2578-2580)GGA>GTA	p.G860V	TRPS1_uc011lhy.1_Missense_Mutation_p.G864V|TRPS1_uc003yny.2_Missense_Mutation_p.G873V|TRPS1_uc010mcy.2_Missense_Mutation_p.G860V	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	860					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGACTTCTCTCCGCCAGCTGG	0.567			NA							Langer-Giedion_syndrome				10	64					2.17888e-05	2.54784e-05	0.006214	1	0
COLEC10	10584	broad.mit.edu	37	8	120118127	120118127	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:120118127G>A	uc003yoo.2	+	6	628	c.531G>A	c.(529-531)AGG>AGA	p.R177R		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	177	C-type lectin.					collagen|cytoplasm	mannose binding			ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			CCCACTGCAGGATTCGGGGTG	0.507			NA											28	31					0	0	0.003271	0	0
ZNF572	137209	broad.mit.edu	37	8	125989981	125989981	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:125989981G>T	uc003yrr.2	+	3	1626	c.1471G>T	c.(1471-1473)GTA>TTA	p.V491L		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GAAAATTCACGTAGAAAAGCC	0.468			NA								HNSCC(60;0.17)			72	74					1.2647e-45	2.42046e-45	0.00361	1	0
COL22A1	169044	broad.mit.edu	37	8	139606332	139606332	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:139606332C>A	uc003yvd.2	-	63	4990	c.4543G>T	c.(4543-4545)GGC>TGC	p.G1515C	COL22A1_uc011ljo.1_Missense_Mutation_p.G795C	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1515	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCATGGGGCCGGCCCGGCCT	0.652			NA								HNSCC(7;0.00092)			11	66					3.86212e-05	4.42498e-05	0.008291	1	0
COL22A1	169044	broad.mit.edu	37	8	139833475	139833475	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:139833475C>A	uc003yvd.2	-	7	1596	c.1149G>T	c.(1147-1149)GCG>GCT	p.A383A		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	383	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCTGCACCAGCGCACAGTCAA	0.567			NA								HNSCC(7;0.00092)			9	51					7.48243e-07	9.20222e-07	0.006214	1	0
DENND3	22898	broad.mit.edu	37	8	142176321	142176321	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:142176321C>T	uc003yvy.2	+	12	1624	c.1346C>T	c.(1345-1347)CCG>CTG	p.P449L	DENND3_uc010mep.2_Missense_Mutation_p.P410L|DENND3_uc003yvz.1_Missense_Mutation_p.P133L	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	449										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAAGGAGACCGACCGTTGAG	0.483			NA											37	232					0	0	0.005524	0	0
PLEC	5339	broad.mit.edu	37	8	144997654	144997654	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:144997654C>T	uc003zaf.1	-	31	7024	c.6854G>A	c.(6853-6855)CGG>CAG	p.R2285Q	PLEC_uc003zab.1_Missense_Mutation_p.R2148Q|PLEC_uc003zac.1_Missense_Mutation_p.R2152Q|PLEC_uc003zad.2_Missense_Mutation_p.R2148Q|PLEC_uc003zae.1_Missense_Mutation_p.R2116Q|PLEC_uc003zag.1_Missense_Mutation_p.R2126Q|PLEC_uc003zah.2_Missense_Mutation_p.R2134Q|PLEC_uc003zaj.2_Missense_Mutation_p.R2175Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2285	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTGTGCCCGCCGCGCCGCCTC	0.687			NA											6	6					0	0	0.004482	0	0
OPLAH	26873	broad.mit.edu	37	8	145113227	145113227	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr8:145113227C>G	uc003zar.3	-	7	946	c.864G>C	c.(862-864)TCG>TCC	p.S288S	OPLAH_uc003zat.1_Silent_p.S66S	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	288							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CGGCCGGGCCCGAGAGCACAG	0.682			NA											7	6					0	0	0.00308	0	0
DMRT3	58524	broad.mit.edu	37	9	977258	977258	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:977258T>G	uc003zgw.1	+	1	295	c.257T>G	c.(256-258)CTC>CGC	p.L86R		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	86					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		TTGGAGAGCCTCATCCCCGAC	0.443			NA											7	13					0	0	0.00308	0	0
SMARCA2	6595	broad.mit.edu	37	9	2054677	2054677	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:2054677C>T	uc003zhc.2	+	6	1226	c.1127C>T	c.(1126-1128)GCA>GTA	p.A376V	SMARCA2_uc003zhd.2_Missense_Mutation_p.A376V|SMARCA2_uc010mha.2_Missense_Mutation_p.A367V	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	376					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AGAACCAAAGCAACCGTGGAA	0.408			NA											25	48					0	0	0.005443	0	0
SH3GL2	6456	broad.mit.edu	37	9	17789527	17789527	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:17789527G>T	uc003zna.2	+	6	891	c.603G>T	c.(601-603)ATG>ATT	p.M201I	SH3GL2_uc011lmx.1_Missense_Mutation_p.M166I|SH3GL2_uc011lmy.1_Missense_Mutation_p.M154I	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	201	BAR.|Potential.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AGTCAAGCATGTTCAATCTCT	0.373			NA											27	31					1.77063e-15	2.88151e-15	0.005443	1	0
TAF1L	138474	broad.mit.edu	37	9	32634278	32634278	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:32634278T>C	uc003zrg.1	-	1	1390	c.1300A>G	c.(1300-1302)ATC>GTC	p.I434V	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	434					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCATCCCAGATGATAGAATCC	0.468			NA											40	153					0	0	0.006999	0	0
SMU1	55234	broad.mit.edu	37	9	33071822	33071822	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:33071822G>A	uc003zsf.1	-	3	414	c.306C>T	c.(304-306)CCC>CCT	p.P102P	SMU1_uc010mjo.1_Silent_p.P102P|SMU1_uc010mjp.1_Silent_p.P102P|SMU1_uc011lnu.1_Intron	NM_018225	NP_060695	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog	102						cytoplasm|nucleus				ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		ACATGATCATGGGATCAGTCT	0.418			NA											50	42					0	0	0.00361	0	0
NPR2	4882	broad.mit.edu	37	9	35792526	35792526	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:35792526G>A	uc003zyd.2	+	1	121	c.121G>A	c.(121-123)GCC>ACC	p.A41T	NPR2_uc010mlb.2_Missense_Mutation_p.A41T	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	41	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CTATGCCTGGGCCTGGCCACG	0.697			NA											10	9					0	0	0.000978	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627176	43627176	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:43627176G>T	uc011lrb.1	-	4	1540	c.1511C>A	c.(1510-1512)CCA>CAA	p.P504Q		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	504						integral to membrane					0						AGATAGGACTGGGAAAGAAGA	0.532			NA											136	217					1.2273e-65	2.36661e-65	0.00361	1	0
RORB	6096	broad.mit.edu	37	9	77282816	77282816	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:77282816A>G	uc004aji.2	+	8	1192	c.1143A>G	c.(1141-1143)CCA>CCG	p.P381P	RORB_uc004ajh.2_Silent_p.P370P	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	381	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TGATATCTCCAGGTAGGGCAG	0.403			NA											5	80					0	0	0.001984	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609573	84609573	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:84609573T>A	uc004amn.2	+	4	4235	c.4188T>A	c.(4186-4188)TTT>TTA	p.F1396L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1396						integral to membrane					0						GAGCTGCCTTTACTGGGACTA	0.453			NA											7	8					0	0	0.00308	0	0
ECM2	1842	broad.mit.edu	37	9	95263280	95263280	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:95263280G>T	uc004ash.2	-	9	1725	c.1660C>A	c.(1660-1662)CTA>ATA	p.L554I	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.L532I|ECM2_uc011lty.1_Missense_Mutation_p.L554I|ECM2_uc004asg.2_Missense_Mutation_p.L532I|ECM2_uc010mqz.1_5'UTR	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	554	LRR 8.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						GACTTGGGTAGATAGGACGGG	0.473			NA											33	37					4.74835e-14	7.5121e-14	0.002096	1	0
COL15A1	1306	broad.mit.edu	37	9	101788185	101788185	+	Splice_Site	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:101788185G>A	uc004azb.1	+	16	2187	c.1981_splice	c.e16-1	p.G661_splice		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor						angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				ATGTTCCCCAGGGCCCTGAGG	0.577			NA											6	8					0	0	0.001984	0	0
SMC2	10592	broad.mit.edu	37	9	106901507	106901507	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:106901507G>T	uc004bbv.2	+	25	3793	c.3505G>T	c.(3505-3507)GCC>TCC	p.A1169S	SMC2_uc004bbw.2_Missense_Mutation_p.A1169S|SMC2_uc011lvl.1_Missense_Mutation_p.A1169S|SMC2_uc004bbx.2_Missense_Mutation_p.A1169S|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1169					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						TTCTACAGTAGCCAGATTTAC	0.358			NA											20	25					5.03518e-11	7.25805e-11	0.007413	1	0
OR13F1	138805	broad.mit.edu	37	9	107267268	107267269	+	Missense_Mutation	DNP	CA	CA	TG			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:107267268_107267269CA>TG	uc011lvm.1	+	1	725_726	c.725_726CA>TG	c.(724-726)ACA>ATG	p.T242M		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						TCAACGTGCACAGCCCACCTGA	0.46			NA											39	58					0	0	0.004672	0	0
OR13C8	138802	broad.mit.edu	37	9	107331656	107331656	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:107331656G>T	uc011lvo.1	+	1	208	c.208G>T	c.(208-210)GAC>TAC	p.D70Y		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCCTTCCTCGACGTTTGCTA	0.428			NA											48	140					4.18559e-23	7.53111e-23	0.00361	1	0
OR13C8	138802	broad.mit.edu	37	9	107331807	107331807	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:107331807T>A	uc011lvo.1	+	1	359	c.359T>A	c.(358-360)CTG>CAG	p.L120Q		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACGATGGCACTGGACCGCTAT	0.527			NA											20	25					0	0	0.008871	0	0
RGS3	5998	broad.mit.edu	37	9	116279846	116279846	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:116279846G>A	uc004bhq.2	+	17	1909	c.1700G>A	c.(1699-1701)CGG>CAG	p.R567Q	RGS3_uc004bhr.2_Missense_Mutation_p.R455Q|RGS3_uc004bhs.2_Missense_Mutation_p.R457Q|RGS3_uc004bht.2_Missense_Mutation_p.R286Q|RGS3_uc010muy.2_Missense_Mutation_p.R286Q|RGS3_uc004bhu.2_Missense_Mutation_p.R193Q	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	567					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						AATCCTGCCCGGACCCTCCTG	0.557			NA											3	47					0	0	0.009096	0	0
ASTN2	23245	broad.mit.edu	37	9	119488128	119488128	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:119488128A>G	uc004bjs.1	-	16	2829	c.2728T>C	c.(2728-2730)TAT>CAT	p.Y910H	ASTN2_uc004bjr.1_Missense_Mutation_p.Y906H|ASTN2_uc004bjt.1_Missense_Mutation_p.Y859H	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	910	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TCTGAGCCATAGAGGGCCTCT	0.547			NA											16	109					0	0	0.004007	0	0
ASTN2	23245	broad.mit.edu	37	9	119625959	119625959	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:119625959G>C	uc004bjs.1	-	11	2044	c.1943C>G	c.(1942-1944)TCC>TGC	p.S648C	ASTN2_uc004bjr.1_Missense_Mutation_p.S644C|ASTN2_uc004bjt.1_Missense_Mutation_p.S597C	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	648	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TGGCCCGAAGGAAGACAGCAG	0.522			NA											17	15					0	0	0.00499	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377093	125377093	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:125377093C>T	uc011lyy.1	+	1	77	c.77C>T	c.(76-78)CCA>CTA	p.P26L		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGCAAATCCCACTCTTCCTT	0.468			NA											45	59					0	0	0.00361	0	0
FPGS	2356	broad.mit.edu	37	9	130569352	130569352	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:130569352C>A	uc004bsg.1	+	5	537	c.487C>A	c.(487-489)CTG>ATG	p.L163M	FPGS_uc004bsh.1_Translation_Start_Site|FPGS_uc011mal.1_Missense_Mutation_p.L163M|FPGS_uc004bsi.1_Missense_Mutation_p.L113M	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	163					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	CTACCACCGGCTGGAGGAGAC	0.637			NA											8	56					0.00307968	0.00329919	0.00308	1	0
NAIF1	203245	broad.mit.edu	37	9	130825873	130825873	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:130825873T>A	uc004bta.2	-	2	1037	c.818A>T	c.(817-819)CAG>CTG	p.Q273L	NAIF1_uc004bsz.2_RNA	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	273					apoptosis|induction of apoptosis	nucleus					0						CTCCATGGCCTGGGCCTGGCG	0.617			NA											22	30					0	0	0.00278	0	0
WDR34	89891	broad.mit.edu	37	9	131398630	131398630	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:131398630C>T	uc004bvq.1	-	4	757	c.633G>A	c.(631-633)TCG>TCA	p.S211S	WDR34_uc004bvs.1_Silent_p.S202S|WDR34_uc004bvr.1_Silent_p.S211S|WDR34_uc011mbi.1_Silent_p.S94S	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	211						cytoplasm				central_nervous_system(2)|skin(1)	3						CCACCACGGCCGACGGCTGCT	0.677			NA											4	9					0	0	0.009096	0	0
TSC1	7248	broad.mit.edu	37	9	135797337	135797337	+	Missense_Mutation	SNP	C	C	G	rs118203395		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:135797337C>G	uc004cca.2	-	7	766	c.532G>C	c.(532-534)GTC>CTC	p.V178L	TSC1_uc004ccb.3_Missense_Mutation_p.V178L|TSC1_uc011mcq.1_Missense_Mutation_p.V127L|TSC1_uc011mcr.1_Missense_Mutation_p.V57L|TSC1_uc011mcs.1_Missense_Mutation_p.V57L|TSC1_uc004ccc.1_Missense_Mutation_p.V178L|TSC1_uc004ccd.2_Missense_Mutation_p.V178L|TSC1_uc004cce.1_Missense_Mutation_p.V178L	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	178					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TGGAGATGGACGAGATAGACT	0.463			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				32	34					0	0	0.002096	0	0
GFI1B	8328	broad.mit.edu	37	9	135864468	135864468	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:135864468G>T	uc004ccg.2	+	5	682	c.531G>T	c.(529-531)GGG>GGT	p.G177G	GFI1B_uc010mzy.2_Intron	NM_004188	NP_004179	Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription	177	C2H2-type 1.|Mediates interaction with GATA1.|Interaction with ARIH2.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CCCCTCACGGGCTCGAAGTGC	0.652			NA											7	17					8.12818e-05	9.14868e-05	0.001984	1	0
ABO	28	broad.mit.edu	37	9	136131636	136131636	+	Missense_Mutation	SNP	C	C	T	rs8176738		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:136131636C>T	uc004cda.1	-	8	507	c.482G>A	c.(481-483)CGC>CAC	p.R161H	ABO_uc010naf.1_Missense_Mutation_p.R20H|ABO_uc011mcz.1_Missense_Mutation_p.R20H|ABO_uc010nag.1_Missense_Mutation_p.R20H	NM_020469	NP_065202	P16442	BGAT_HUMAN	ABO blood group (alpha	161	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		CAGCGTCACGCGGGGCACCGC	0.647			NA											5	16					0	0	0.000602	0	0
SLC34A3	142680	broad.mit.edu	37	9	140126579	140126579	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr9:140126579C>A	uc004cmf.1	+	3	327	c.141C>A	c.(139-141)CTC>CTA	p.L47L	SLC34A3_uc004cmc.1_5'UTR|SLC34A3_uc004cmd.1_Silent_p.L47L|SLC34A3_uc011met.1_Silent_p.L47L	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	47	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CCTGGACCCTCCCTCAGCTGA	0.627			NA											40	54					4.67007e-22	8.24319e-22	0.00874	1	0
PPP2R3B	28227	broad.mit.edu	37	X	347161	347161	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:347161G>C	uc004cpg.2	-	1	467	c.266C>G	c.(265-267)TCC>TGC	p.S89C	PPP2R3B_uc011mha.1_5'UTR	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	89					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTGGGGCTGGAGGCGGCGCC	0.731			NA											8	12					0	0	0.006214	0	0
ASMT	438	broad.mit.edu	37	X	1743279	1743279	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:1743279C>T	uc004cqd.2	+	4	507	c.362C>T	c.(361-363)GCA>GTA	p.A121V	ASMT_uc010ncy.2_Missense_Mutation_p.A121V|ASMT_uc004cqe.2_Missense_Mutation_p.A121V	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	121					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCCACCTGGCAGACGCCGTG	0.672			NA											4	70					0	0	0.009096	0	0
MXRA5	25878	broad.mit.edu	37	X	3228004	3228004	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:3228004G>T	uc004crg.3	-	7	8397	c.8240C>A	c.(8239-8241)CCC>CAC	p.P2747H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2747	Ig-like C2-type 12.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGTGTTCCCGGGCCGGGTGTA	0.597			NA											24	47					7.92952e-12	1.16772e-11	0.003954	1	0
MXRA5	25878	broad.mit.edu	37	X	3240048	3240048	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:3240048G>T	uc004crg.3	-	5	3835	c.3678C>A	c.(3676-3678)TCC>TCA	p.S1226S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1226						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTGTTCCCTTGGATGTGGGTT	0.498			NA											32	98					1.08312e-15	1.76829e-15	0.009535	1	0
MXRA5	25878	broad.mit.edu	37	X	3240386	3240386	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:3240386C>A	uc004crg.3	-	5	3497	c.3340G>T	c.(3340-3342)GAA>TAA	p.E1114*		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1114						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACTGTGGTTTCCGCAGGCTTC	0.493			NA											26	40					2.41591e-17	4.06096e-17	0.004656	1	0
NLGN4X	57502	broad.mit.edu	37	X	5821809	5821809	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:5821809C>T	uc010ndh.2	-	5	1411	c.910G>A	c.(910-912)GTC>ATC	p.V304I	NLGN4X_uc004crp.2_Missense_Mutation_p.V324I|NLGN4X_uc004crq.2_Missense_Mutation_p.V304I|NLGN4X_uc010ndi.2_Missense_Mutation_p.V341I|NLGN4X_uc004crr.2_Missense_Mutation_p.V304I|NLGN4X_uc010ndj.2_Missense_Mutation_p.V304I	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	304	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TTGCAGCCGACCTTGTCTGCC	0.577			NA											16	63					0	0	0.007413	0	0
TLR8	51311	broad.mit.edu	37	X	12937852	12937852	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:12937852C>G	uc004cve.2	+	2	761	c.693C>G	c.(691-693)AAC>AAG	p.N231K	TLR8_uc004cvd.2_Missense_Mutation_p.N249K	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	231	LRR 5.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TTCTGAGCAACACCCAGATCA	0.408			NA											19	103					0	0	0.008871	0	0
BMX	660	broad.mit.edu	37	X	15554498	15554498	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:15554498C>A	uc004cww.2	+	13	1358	c.1170C>A	c.(1168-1170)CAC>CAA	p.H390Q	BMX_uc004cwx.3_Missense_Mutation_p.H390Q|BMX_uc004cwy.3_Missense_Mutation_p.H390Q	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	390	SH2.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					GGCTCCGCCACCCTGTGTCAA	0.328			NA											27	111					2.08457e-15	3.38163e-15	0.002096	1	0
GPR64	10149	broad.mit.edu	37	X	19031889	19031889	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:19031889T>A	uc004cyx.2	-	16	1178	c.1014A>T	c.(1012-1014)CCA>CCT	p.P338P	GPR64_uc004cyy.2_Silent_p.P335P|GPR64_uc004cyz.2_Silent_p.P324P|GPR64_uc004czb.2_Silent_p.P338P|GPR64_uc004czc.2_Silent_p.P322P|GPR64_uc004czd.2_Silent_p.P314P|GPR64_uc004cze.2_Silent_p.P308P|GPR64_uc004czf.2_Silent_p.P300P|GPR64_uc004cza.2_Silent_p.P316P|GPR64_uc004cyw.2_Silent_p.P322P|GPR64_uc010nfj.2_Silent_p.P308P	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	338	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TCACAGGAGGTGGGGTGCCGG	0.562			NA											24	117					0	0	0.004656	0	0
CNKSR2	22866	broad.mit.edu	37	X	21534736	21534736	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:21534736C>A	uc004czx.1	+	9	980	c.944C>A	c.(943-945)CCC>CAC	p.P315H	CNKSR2_uc004czw.2_Missense_Mutation_p.P315H|CNKSR2_uc011mjn.1_Intron|CNKSR2_uc011mjo.1_Missense_Mutation_p.P315H	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	315					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AGATGGAAGCCCCTTGCTCTG	0.418			NA											16	57					5.3912e-06	6.41421e-06	0.006122	1	0
CNKSR2	22866	broad.mit.edu	37	X	21667055	21667055	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:21667055G>T	uc004czx.1	+	21	2835	c.2799G>T	c.(2797-2799)ATG>ATT	p.M933I	CNKSR2_uc011mjo.1_Missense_Mutation_p.M903I	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	933					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						CAACCAAGATGGAATACAAGC	0.388			NA											24	121					2.24059e-21	3.94129e-21	0.00632	1	0
PTCHD1	139411	broad.mit.edu	37	X	23412273	23412273	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:23412273C>A	uc004dal.3	+	3	2646	c.2638C>A	c.(2638-2640)CGT>AGT	p.R880S		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	880					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CGATAGTACCCGTGTGGTTGA	0.378			NA											27	70					1.17739e-12	1.79062e-12	0.005443	1	0
MAGEB4	4115	broad.mit.edu	37	X	30260998	30260998	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:30260998T>A	uc004dcb.2	+	1	830	c.746T>A	c.(745-747)CTG>CAG	p.L249Q	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	249	MAGE.									ovary(1)	1						ACCCAAGATCTGGTACAGGAA	0.493			NA											9	41					0	0	0.006214	0	0
DMD	1756	broad.mit.edu	37	X	32591656	32591656	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:32591656T>C	uc004dda.1	-	15	2047	c.1803A>G	c.(1801-1803)CAA>CAG	p.Q601Q	DMD_uc004dcz.2_Silent_p.Q478Q|DMD_uc004dcy.1_Silent_p.Q597Q|DMD_uc004ddb.1_Silent_p.Q593Q|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Silent_p.Q593Q|DMD_uc010ngp.1_3'UTR|DMD_uc010ngq.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	601	Spectrin 3.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CGGCCAGTTTTTGAAGACTTG	0.323			NA											26	45					0	0	0.004656	0	0
DMD	1756	broad.mit.edu	37	X	32591898	32591898	+	Silent	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:32591898G>A	uc004dda.1	-	14	1912	c.1668C>T	c.(1666-1668)GAC>GAT	p.D556D	DMD_uc004dcz.2_Silent_p.D433D|DMD_uc004dcy.1_Silent_p.D552D|DMD_uc004ddb.1_Silent_p.D548D|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Silent_p.D548D|DMD_uc010ngp.1_Missense_Mutation_p.T76I|DMD_uc010ngq.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	556	Spectrin 2.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGAGAAGGATGTCTTGTAAAA	0.433			NA											5	28					0	0	0.000602	0	0
FAM47A	158724	broad.mit.edu	37	X	34150342	34150342	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:34150342C>T	uc004ddg.2	-	1	87	c.54G>A	c.(52-54)AAG>AAA	p.K18K		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	18										ovary(4)|central_nervous_system(1)	5						AGTACCAGGGCTTGGAGTCCA	0.612			NA											19	39					0	0	0.007413	0	0
FAM47B	170062	broad.mit.edu	37	X	34961712	34961712	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:34961712G>T	uc004ddi.1	+	1	782	c.764G>T	c.(763-765)GGA>GTA	p.G255V		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	255	Pro-rich.									ovary(3)|breast(1)	4						CCCGAGACTGGAGTGTCCCAT	0.637			NA											14	41					9.05144e-12	1.33102e-11	0.001855	1	0
FAM47C	442444	broad.mit.edu	37	X	37028757	37028757	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:37028757C>G	uc004ddl.1	+	1	2288	c.2274C>G	c.(2272-2274)CGC>CGG	p.R758R		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	758										ovary(3)	3						TTGAGACTCGCGTATCTCATC	0.632			NA											19	27					0	0	0.001882	0	0
CYBB	1536	broad.mit.edu	37	X	37653016	37653016	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:37653016G>T	uc004ddr.2	+	5	497	c.436G>T	c.(436-438)GAC>TAC	p.D146Y	CYBB_uc011mke.1_Intron|CYBB_uc011mkf.1_Missense_Mutation_p.D114Y|CYBB_uc011mkg.1_Intron	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	146	Extracellular (Potential).|Ferric oxidoreductase.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						TGAACTTGGAGACAGGCAAAA	0.383			NA											21	94					6.33239e-15	1.02077e-14	0.010504	1	0
ATP6AP2	10159	broad.mit.edu	37	X	40464916	40464916	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:40464916T>G	uc004det.2	+	9	1064	c.962T>G	c.(961-963)GTG>GGG	p.V321G	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.V245G|ATP6AP2_uc011mkm.1_Missense_Mutation_p.V289G|ATP6AP2_uc011mkn.1_Missense_Mutation_p.V243G|ATP6AP2_uc004deu.1_Missense_Mutation_p.V185G	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	321	Helical; (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						GCCTTGGCTGTGATTATCACC	0.373			NA											9	80					0	0	0.004482	0	0
NYX	60506	broad.mit.edu	37	X	41333566	41333566	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:41333566G>C	uc004dfh.2	+	2	1290	c.860G>C	c.(859-861)CGC>CCC	p.R287P	NYX_uc011mku.1_Missense_Mutation_p.R282P	NM_022567	NP_072089	Q9GZU5	NYX_HUMAN	nyctalopin precursor	287	LRR 10.				response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				lung(2)	2						TACCTGGACCGCAACAGCATC	0.701			NA											9	33					0	0	0.006214	0	0
CASK	8573	broad.mit.edu	37	X	41495914	41495914	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:41495914C>A	uc004dfl.3	-	9	878	c.832G>T	c.(832-834)GAG>TAG	p.E278*	CASK_uc004dfk.3_Nonsense_Mutation_p.E93*|CASK_uc004dfm.3_Nonsense_Mutation_p.E278*|CASK_uc004dfn.3_Nonsense_Mutation_p.E278*	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	278					cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						CGATCCCGCTCCTATGTAAGA	0.313	NSCLC(42;104 1086 3090 27189 35040)		NA											16	57					1.99824e-07	2.50269e-07	0.00499	1	0
USP11	8237	broad.mit.edu	37	X	47106710	47106710	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:47106710G>T	uc004dhp.2	+	19	2557	c.2557G>T	c.(2557-2559)GAC>TAC	p.D853Y	USP11_uc004dhq.2_Missense_Mutation_p.D579Y	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	853					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CAGGGACCTGGACTTCTCTGA	0.557			NA											26	30					2.41591e-17	4.06096e-17	0.004656	1	0
HDAC6	10013	broad.mit.edu	37	X	48663850	48663850	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:48663850C>G	uc011mmi.1	+	5	412	c.317C>G	c.(316-318)CCG>CGG	p.P106R	HDAC6_uc004dkr.1_Missense_Mutation_p.P106R|HDAC6_uc004dks.1_Missense_Mutation_p.P106R|HDAC6_uc010nig.1_5'UTR|HDAC6_uc004dkt.1_Missense_Mutation_p.P106R|HDAC6_uc004dku.3_Missense_Mutation_p.P106R|HDAC6_uc011mmj.1_Missense_Mutation_p.P51R|HDAC6_uc011mmk.1_Missense_Mutation_p.P87R	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	106	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	CCCAGCTTCCCGGAAGGCCCT	0.592	Pancreas(112;205 1675 2305 8976 15959)		NA											6	9					0	0	0.004482	0	0
CACNA1F	778	broad.mit.edu	37	X	49063081	49063081	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:49063081C>A	uc004dnb.2	-	46	5458	c.5396G>T	c.(5395-5397)CGG>CTG	p.R1799L	CACNA1F_uc010nip.2_Missense_Mutation_p.R1788L	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1799	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GGAGGGCTTCCGACCTGGGGG	0.612			NA											7	33					0.000274275	0.00030271	0.004482	1	0
CACNA1F	778	broad.mit.edu	37	X	49063213	49063213	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:49063213G>A	uc004dnb.2	-	45	5430	c.5368C>T	c.(5368-5370)CGT>TGT	p.R1790C	CACNA1F_uc010nip.2_Missense_Mutation_p.R1779C	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1790	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GGCAGCAGACGGCGGCGTGGT	0.612			NA											22	30					0	0	0.00632	0	0
CCNB3	85417	broad.mit.edu	37	X	50089805	50089805	+	Missense_Mutation	SNP	G	G	T	rs61751434	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:50089805G>T	uc004dox.3	+	10	4107	c.3809G>T	c.(3808-3810)AGG>ATG	p.R1270M	CCNB3_uc004doy.2_Missense_Mutation_p.R1270M|CCNB3_uc004doz.2_Missense_Mutation_p.R166M|CCNB3_uc010njq.2_Missense_Mutation_p.R162M|CCNB3_uc004dpa.2_Missense_Mutation_p.R109M	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1270					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					AGATATGCTAGGGTAAGAGAG	0.468			NA											9	18					7.48243e-07	9.20222e-07	0.006214	1	0
KLF8	11279	broad.mit.edu	37	X	56310868	56310868	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:56310868C>A	uc004dur.2	+	6	1967	c.1021C>A	c.(1021-1023)CGC>AGC	p.R341S	KLF8_uc011mop.1_3'UTR|KLF8_uc010nkh.2_RNA	NM_007250	NP_009181	O95600	KLF8_HUMAN	Kruppel-like factor 8 isoform 1	341	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGACTGCAACCGCAGCTTTTC	0.562			NA											3	24					0.004672	0.00495824	0.004672	1	0
HEPH	9843	broad.mit.edu	37	X	65413471	65413471	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:65413471G>T	uc011moz.1	+	8	1429	c.1369G>T	c.(1369-1371)GGA>TGA	p.G457*	HEPH_uc004dwn.2_Nonsense_Mutation_p.G457*|HEPH_uc004dwo.2_Nonsense_Mutation_p.G187*|HEPH_uc010nkr.2_Nonsense_Mutation_p.G457*|HEPH_uc011mpa.1_Nonsense_Mutation_p.G457*	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	454	Extracellular (Potential).|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TAGGCATCTTGGAATCCTGGG	0.428			NA											14	32					1.15088e-07	1.44674e-07	0.004007	1	0
HEPH	9843	broad.mit.edu	37	X	65428009	65428009	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:65428009T>C	uc011moz.1	+	15	2553	c.2493T>C	c.(2491-2493)AAT>AAC	p.N831N	HEPH_uc004dwn.2_Silent_p.N831N|HEPH_uc004dwo.2_Silent_p.N561N|HEPH_uc010nkr.2_Silent_p.N639N|HEPH_uc011mpa.1_Silent_p.N831N|HEPH_uc010nks.2_Silent_p.N120N	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	828	Extracellular (Potential).|Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TATTCAAGAATAATGCCAGCC	0.428			NA											8	9					0	0	0.004482	0	0
EDA	1896	broad.mit.edu	37	X	68836384	68836384	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:68836384C>T	uc004dxs.2	+	1	474	c.232C>T	c.(232-234)CTT>TTT	p.L78F	EDA_uc004dxr.2_Missense_Mutation_p.L78F|EDA_uc011mpj.1_Missense_Mutation_p.L78F|EDA_uc004dxn.1_Missense_Mutation_p.L78F|EDA_uc004dxm.1_Missense_Mutation_p.L78F|EDA_uc004dxp.1_Missense_Mutation_p.L78F|EDA_uc004dxq.1_Missense_Mutation_p.L78F|EDA_uc004dxl.1_Missense_Mutation_p.L78F	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	78	Extracellular (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						CGAGTCCCGCCTTGGCGGCTC	0.672			NA											7	31					0	0	0.001984	0	0
ACRC	93953	broad.mit.edu	37	X	70811981	70811981	+	Silent	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:70811981T>A	uc004eae.2	+	3	570	c.69T>A	c.(67-69)CTT>CTA	p.L23L	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	23						nucleus				ovary(3)	3	Renal(35;0.156)					GTTACATCCTTAATGTTCAGT	0.373			NA											15	73					0	0	0.00245	0	0
ATRX	546	broad.mit.edu	37	X	76953071	76953071	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:76953071C>A	uc004ecp.3	-	4	474	c.242G>T	c.(241-243)AGG>ATG	p.R81M	ATRX_uc004ecq.3_Missense_Mutation_p.R81M|ATRX_uc004eco.3_Translation_Start_Site|ATRX_uc004ecr.2_Missense_Mutation_p.R81M|ATRX_uc010nlx.1_Missense_Mutation_p.R81M|ATRX_uc010nly.1_Missense_Mutation_p.R26M	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	81					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATCAACCAACCTCTTTGATCG	0.343			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						13	82					1.62849e-17	2.76006e-17	0.004007	1	0
SATL1	340562	broad.mit.edu	37	X	84362769	84362769	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:84362769G>T	uc011mqx.1	-	1	1206	c.1206C>A	c.(1204-1206)AGC>AGA	p.S402R	SATL1_uc004een.2_Missense_Mutation_p.S402R	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	215	Gln-rich.						N-acetyltransferase activity			breast(2)	2						TGCCTGATTGGCTGGTGCCTA	0.537			NA											11	61					0.00010058	0.000112959	0.001368	1	0
TGIF2LX	90316	broad.mit.edu	37	X	89177645	89177645	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:89177645C>A	uc004efe.2	+	2	610	c.561C>A	c.(559-561)GCC>GCA	p.A187A		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	187						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCGGAATAGCCCAGCCGAAGA	0.567			NA											4	21					0.000602214	0.000660368	0.000602	1	0
PABPC5	140886	broad.mit.edu	37	X	90691663	90691663	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:90691663G>T	uc004efg.2	+	2	1527	c.1087G>T	c.(1087-1089)GGC>TGC	p.G363C	PABPC5_uc004eff.1_Missense_Mutation_p.G199C	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	363	RRM 4.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TGAGATGAATGGCCGCATAGT	0.532			NA											16	67					1.15088e-07	1.44674e-07	0.004007	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873299	91873299	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:91873299C>A	uc004efk.1	+	7	4249	c.3404C>A	c.(3403-3405)GCC>GAC	p.A1135D	PCDH11X_uc004efl.1_Missense_Mutation_p.A1125D|PCDH11X_uc004efo.1_Missense_Mutation_p.A1098D|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.A1127D|PCDH11X_uc004efn.1_Missense_Mutation_p.A1117D	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1135	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GTGGAAGAGGCCTCTGACAAC	0.433	NSCLC(38;925 1092 2571 38200 45895)		NA											31	11					7.01153e-11	9.98021e-11	0.007291	1	0
TNMD	64102	broad.mit.edu	37	X	99854595	99854595	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:99854595G>A	uc004efy.3	+	7	1061	c.835G>A	c.(835-837)GTC>ATC	p.V279I	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	279	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						TTGCCGCCGCGTCTGTGAACC	0.488			NA											4	31					0	0	0.009096	0	0
ARMCX2	9823	broad.mit.edu	37	X	100912509	100912509	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:100912509G>T	uc004eid.2	-	3	421	c.66C>A	c.(64-66)TAC>TAA	p.Y22*	ARMCX2_uc004eie.3_Nonsense_Mutation_p.Y22*|ARMCX2_uc004eif.3_Nonsense_Mutation_p.Y22*|ARMCX2_uc004eig.3_Nonsense_Mutation_p.Y22*|ARMCX2_uc010nnt.2_Nonsense_Mutation_p.Y22*	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	22	Helical; (Potential).					integral to membrane	binding			ovary(6)	6						TGTAGACACAGTACCAGGCAC	0.473			NA											16	62					0.000422831	0.000465661	0.004007	1	0
IL1RAPL2	26280	broad.mit.edu	37	X	105011394	105011394	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:105011394G>A	uc004elz.1	+	11	2557	c.1801G>A	c.(1801-1803)GCT>ACT	p.A601T		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	601	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GTCATCTCAGGCTGATCTCCC	0.488			NA											14	91					0	0	0.00245	0	0
PSMD10	5716	broad.mit.edu	37	X	107331000	107331000	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:107331000G>T	uc004enp.1	-	4	541	c.443C>A	c.(442-444)GCC>GAC	p.A148D	PSMD10_uc004enq.1_Missense_Mutation_p.A148D|PSMD10_uc010nph.1_Missense_Mutation_p.A99D	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	148	ANK 5.|Interaction with RELA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						GTTACCCTTGGCTGCTGCCCG	0.473			NA											39	119					4.67007e-22	8.24319e-22	0.00874	1	0
COL4A6	1288	broad.mit.edu	37	X	107402931	107402931	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:107402931A>T	uc004enw.3	-	44	4679	c.4576T>A	c.(4576-4578)TAC>AAC	p.Y1526N	COL4A6_uc004env.3_Missense_Mutation_p.Y1525N|COL4A6_uc011msn.1_Missense_Mutation_p.Y1501N|COL4A6_uc010npk.2_Missense_Mutation_p.Y1468N|COL4A6_uc011msm.1_Missense_Mutation_p.Y60N|COL4A6_uc010npj.2_Missense_Mutation_p.Y5N	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1526	Collagen IV NC1.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						ATGTTGCAGTAGATGAAGGGC	0.582	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				4	216					0	0	0.000602	0	0
COL4A6	1288	broad.mit.edu	37	X	107417735	107417735	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:107417735G>T	uc004enw.3	-	31	3179	c.3076C>A	c.(3076-3078)CGG>AGG	p.R1026R	COL4A6_uc004env.3_Silent_p.R1025R|COL4A6_uc011msn.1_Silent_p.R1025R|COL4A6_uc010npk.2_Silent_p.R1025R	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1026	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						GGTAAGCCCCGGATTCCCATG	0.557	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				13	69					2.27111e-07	2.83058e-07	0.001368	1	0
GUCY2F	2986	broad.mit.edu	37	X	108625421	108625421	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:108625421G>T	uc004eod.3	-	17	3352	c.3076C>A	c.(3076-3078)CTC>ATC	p.L1026I	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1026	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						ACAGTGCTGAGACTGACATGA	0.388			NA											36	188					1.90571e-15	3.0964e-15	0.004289	1	0
GUCY2F	2986	broad.mit.edu	37	X	108684682	108684682	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:108684682C>A	uc004eod.3	-	7	1875	c.1599G>T	c.(1597-1599)CAG>CAT	p.Q533H	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	533	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CTGAGGTAATCTGGAAGCTTA	0.428			NA											95	235					7.70235e-37	1.46045e-36	0.00361	1	0
KCNE1L	23630	broad.mit.edu	37	X	108867952	108867952	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:108867952C>T	uc004eoh.2	-	1	442	c.298G>A	c.(298-300)GAG>AAG	p.E100K		NM_012282	NP_036414	Q9UJ90	KCE1L_HUMAN	potassium voltage-gated channel, Isk-related	100	Cytoplasmic (Potential).				regulation of heart contraction	voltage-gated potassium channel complex					0						CATTCGTGCTCGGCGCAAGCC	0.731			NA											3	11					0	0	0.004672	0	0
GLUD2	2747	broad.mit.edu	37	X	120181573	120181573	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:120181573C>A	uc004eto.2	+	1	112	c.35C>A	c.(34-36)TCC>TAC	p.S12Y		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	12					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	CTGCTGCCGTCCCGGGCCGGG	0.766			NA											9	21					5.50884e-06	6.53894e-06	0.001368	1	0
GRIA3	2892	broad.mit.edu	37	X	122318470	122318470	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:122318470G>A	uc004etq.3	+	2	376	c.83G>A	c.(82-84)GGA>GAA	p.G28E	GRIA3_uc004etr.3_Missense_Mutation_p.G28E|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_5'Flank|GRIA3_uc010nqs.1_Missense_Mutation_p.G28E	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	28					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CATTCTCACGGAGGATTCCCC	0.587			NA											19	88					0	0	0.008871	0	0
STAG2	10735	broad.mit.edu	37	X	123220443	123220443	+	Nonsense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:123220443A>T	uc004etz.3	+	29	3439	c.3100A>T	c.(3100-3102)AGA>TGA	p.R1034*	STAG2_uc004eua.2_Nonsense_Mutation_p.R1034*|STAG2_uc004eub.2_Nonsense_Mutation_p.R1034*|STAG2_uc004euc.2_Nonsense_Mutation_p.R1034*|STAG2_uc004eud.2_Nonsense_Mutation_p.R1034*|STAG2_uc004eue.2_Nonsense_Mutation_p.R1034*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1034					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GTCACTCCGAAGAGAGGATGT	0.423			NA											26	90					0	0	0.008361	0	0
SMARCA1	6594	broad.mit.edu	37	X	128650469	128650469	+	Silent	SNP	G	G	T	rs145557250	byFrequency	TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:128650469G>T	uc004eun.3	-	3	380	c.267C>A	c.(265-267)GCC>GCA	p.A89A	SMARCA1_uc004eup.3_Silent_p.A89A|SMARCA1_uc011muk.1_Silent_p.A89A|SMARCA1_uc011mul.1_Silent_p.A89A	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	89					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TTGCTCGGTCGGCTTTCTAAT	0.294			NA											16	83					2.32078e-09	3.14151e-09	0.003163	1	0
BCORL1	63035	broad.mit.edu	37	X	129147051	129147051	+	Silent	SNP	C	C	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:129147051C>T	uc004evb.1	+	4	417	c.303C>T	c.(301-303)TAC>TAT	p.Y101Y	BCORL1_uc010nrd.1_Silent_p.Y3Y	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	101					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						AAATGGACTACGCTGGGAACG	0.607			NA											15	47					0	0	0.003163	0	0
BCORL1	63035	broad.mit.edu	37	X	129148882	129148882	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:129148882A>T	uc004evb.1	+	4	2248	c.2134A>T	c.(2134-2136)ACC>TCC	p.T712S	BCORL1_uc010nrd.1_Missense_Mutation_p.T614S	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	712					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						ACTGATCAGCACCATTCCTGG	0.602			NA											9	47					0	0	0.006214	0	0
AIFM1	9131	broad.mit.edu	37	X	129272583	129272583	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:129272583C>A	uc004evg.2	-	9	1130	c.952G>T	c.(952-954)GCT>TCT	p.A318S	AIFM1_uc011mur.1_5'Flank|AIFM1_uc011mus.1_Missense_Mutation_p.A318S|AIFM1_uc004evh.2_Missense_Mutation_p.A314S|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	318	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						CTGCCAAGAGCACAGGCCAGT	0.453			NA											20	97					7.45023e-12	1.10031e-11	0.010504	1	0
ENOX2	10495	broad.mit.edu	37	X	129837135	129837135	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:129837135C>G	uc004evw.2	-	5	561	c.143G>C	c.(142-144)GGA>GCA	p.G48A	ENOX2_uc004evx.2_Missense_Mutation_p.G19A|ENOX2_uc004evy.2_Missense_Mutation_p.G19A	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	48					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						CGGTGCCATTCCAAGATTATT	0.413	Ovarian(101;828 1506 2951 9500 35258)		NA											22	81					0	0	0.00278	0	0
IGSF1	3547	broad.mit.edu	37	X	130409602	130409602	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:130409602G>A	uc004ewd.2	-	16	3272	c.3034C>T	c.(3034-3036)CAG>TAG	p.Q1012*	IGSF1_uc004ewe.3_Nonsense_Mutation_p.Q1006*|IGSF1_uc004ewf.2_Nonsense_Mutation_p.Q992*	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1012	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CCCCAGAGCTGCATTGAAGTG	0.537			NA											18	71					0	0	0.006122	0	0
GPC4	2239	broad.mit.edu	37	X	132473343	132473343	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:132473343C>A	uc004exc.1	-	2	399	c.187G>T	c.(187-189)GGT>TGT	p.G63C	GPC4_uc011mvg.1_5'UTR	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	63					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CAGGTAGAACCCTGGGGACAG	0.423			NA											41	28					9.88483e-10	1.35601e-09	0.007835	1	0
GPC4	2239	broad.mit.edu	37	X	132548911	132548911	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:132548911T>C	uc004exc.1	-	1	295	c.83A>G	c.(82-84)AAA>AGA	p.K28R	GPC4_uc011mvg.1_5'Flank	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	28					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CGAGCAACTTTTCGACTTGAG	0.642			NA											13	82					0	0	0.001855	0	0
SLC9A6	10479	broad.mit.edu	37	X	135106567	135106567	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:135106567C>A	uc004ezj.2	+	12	1521	c.1445C>A	c.(1444-1446)ACG>AAG	p.T482K	SLC9A6_uc004ezk.2_Missense_Mutation_p.T514K	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	482					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TTCAGCACCACGCTTCTGATT	0.473			NA											16	106					0.000958276	0.00104744	0.007413	1	0
GPR112	139378	broad.mit.edu	37	X	135443691	135443691	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:135443691G>C	uc004ezu.1	+	12	7513	c.7222G>C	c.(7222-7224)GAG>CAG	p.E2408Q	GPR112_uc010nsb.1_Missense_Mutation_p.E2203Q|GPR112_uc010nsc.1_Missense_Mutation_p.E2036Q	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2408	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CAACCCTACGGAGACAGCCCA	0.403			NA											16	73					0	0	0.00499	0	0
BRS3	680	broad.mit.edu	37	X	135570363	135570363	+	Silent	SNP	T	T	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:135570363T>C	uc004ezv.1	+	1	239	c.90T>C	c.(88-90)GAT>GAC	p.D30D		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	30	Extracellular (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TTTCTAACGATAACACAAATA	0.413			NA											43	42					0	0	0.00874	0	0
ATP11C	286410	broad.mit.edu	37	X	138850587	138850587	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:138850587C>A	uc004faz.2	-	20	2331	c.2232G>T	c.(2230-2232)TGG>TGT	p.W744C	ATP11C_uc004fax.2_5'UTR|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.W744C	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	744	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					GATGTTCTGTCCATGCTCTGA	0.338			NA											29	31					6.38683e-12	9.45992e-12	0.008361	1	0
MAGEC3	139081	broad.mit.edu	37	X	140985492	140985492	+	Silent	SNP	C	C	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:140985492C>G	uc011mwp.1	+	8	1806	c.1806C>G	c.(1804-1806)TCC>TCG	p.S602S	MAGEC3_uc004fbs.2_3'UTR|MAGEC3_uc010nsj.2_3'UTR	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	602	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTTCCATCCTGGTACATGG	0.478			NA											28	108					0	0	0.007291	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994985	140994985	+	Missense_Mutation	SNP	C	C	A	rs150321883		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:140994985C>A	uc004fbt.2	+	4	2081	c.1795C>A	c.(1795-1797)CCT>ACT	p.P599T	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	599							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGG	0.582			NA								HNSCC(15;0.026)			89	477					1.50328e-30	2.79336e-30	0.00361	1	0
MAGEC1	9947	broad.mit.edu	37	X	140996472	140996472	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:140996472C>A	uc004fbt.2	+	4	3568	c.3282C>A	c.(3280-3282)ACC>ACA	p.T1094T	MAGEC1_uc010nsl.1_Silent_p.T161T	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1094	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TAAAGAATACCGTCCCTATTA	0.453			NA								HNSCC(15;0.026)			28	209					8.16721e-17	1.36387e-16	0.002096	1	0
FMR1	2332	broad.mit.edu	37	X	147011477	147011477	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:147011477G>T	uc010nst.2	+	6	619	c.430G>T	c.(430-432)GAG>TAG	p.E144*	FMR1_uc011mwz.1_Nonsense_Mutation_p.E144*|FMR1_uc004fcj.2_Nonsense_Mutation_p.E144*|FMR1_uc004fck.3_Nonsense_Mutation_p.E144*|FMR1_uc004fcl.3_Nonsense_Mutation_p.E5*|FMR1_uc011mxa.1_5'Flank	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	144					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GTGTGCCAAAGAGGCGGCACA	0.328			NA							Fragile_X_syndrome				6	39					0.00198382	0.00213417	0.001984	1	0
MAGEA11	4110	broad.mit.edu	37	X	148798268	148798268	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:148798268G>T	uc004fdq.2	+	5	1224	c.1122G>T	c.(1120-1122)GTG>GTT	p.V374V	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Silent_p.V345V	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	374	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					ACCGGCAGGTGCCCGGCACTG	0.552			NA											139	118					4.74804e-72	9.19034e-72	0.00361	1	0
PASD1	139135	broad.mit.edu	37	X	150832785	150832785	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:150832785T>A	uc004fev.3	+	11	1368	c.1036T>A	c.(1036-1038)TCA>ACA	p.S346T		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	346						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGAGGACTCAGTGGACCT	0.587			NA											7	63					0	0	0.004482	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092781	151092781	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:151092781C>A	uc004fez.2	+	3	801	c.645C>A	c.(643-645)GAC>GAA	p.D215E	MAGEA4_uc004ffa.2_Missense_Mutation_p.D215E|MAGEA4_uc004ffb.2_Missense_Mutation_p.D215E|MAGEA4_uc004ffc.2_Missense_Mutation_p.D215E|MAGEA4_uc004ffd.2_Missense_Mutation_p.D215E	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	215	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGGAGGGCGACAGCGCCTCTG	0.562			NA											13	121					7.93312e-07	9.7214e-07	0.00245	1	0
ATP2B3	492	broad.mit.edu	37	X	152818574	152818574	+	Silent	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:152818574C>A	uc004fht.1	+	11	2031	c.1905C>A	c.(1903-1905)ATC>ATA	p.I635I	ATP2B3_uc004fhs.1_Silent_p.I635I	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	635	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGAAGATCATCGAGCCGATGG	0.627			NA											8	37					5.18039e-06	6.17778e-06	0.00308	1	0
L1CAM	3897	broad.mit.edu	37	X	153137773	153137773	+	Silent	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:153137773G>T	uc004fjb.2	-	4	342	c.234C>A	c.(232-234)CCC>CCA	p.P78P	L1CAM_uc004fjc.2_Silent_p.P78P|L1CAM_uc010nuo.2_Silent_p.P73P|L1CAM_uc004fjd.1_5'Flank|L1CAM_uc004fje.1_Silent_p.P73P	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	78	Extracellular (Potential).|Ig-like C2-type 1.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTCTTCCTTGGGTTTGAAGT	0.607			NA											32	20					2.48696e-23	4.49058e-23	0.003271	1	0
HCFC1	3054	broad.mit.edu	37	X	153220719	153220719	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:153220719G>T	uc004fjp.2	-	17	3659	c.3131C>A	c.(3130-3132)ACC>AAC	p.T1044N		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1044					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGCACTTGGGTGGGCTGGGG	0.597			NA											15	135					4.7546e-09	6.3519e-09	0.004007	1	0
TKTL1	8277	broad.mit.edu	37	X	153539266	153539266	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:153539266T>G	uc004fkg.2	+	4	616	c.430T>G	c.(430-432)TAC>GAC	p.Y144D	TKTL1_uc011mzl.1_Missense_Mutation_p.Y138D|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Missense_Mutation_p.Y88D	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	144					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCTTCCTACTACAGTCTGGA	0.542			NA											3	106					0	0	0.004672	0	0
MTCP1	4515	broad.mit.edu	37	X	154293943	154293943	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:154293943C>A	uc004fmz.2	-	3	853	c.227G>T	c.(226-228)CGC>CTC	p.R76L	MTCP1NB_uc004fmy.2_Intron	NM_001018025	NP_001018025	P56278	MTCP1_HUMAN	mature T-cell proliferation 1	76					cell proliferation					lung(1)	1	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATCCATGTAGCGCTCCTCCGG	0.478			NA	T	TRA@	T cell prolymphocytic leukemia								18	161					8.10497e-08	1.03412e-07	0.010504	1	0
CLIC2	1193	broad.mit.edu	37	X	154507270	154507270	+	Silent	SNP	A	A	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:154507270A>G	uc004fnf.2	-	6	916	c.666T>C	c.(664-666)CGT>CGC	p.R222R		NM_001289	NP_001280	O15247	CLIC2_HUMAN	chloride intracellular channel 2	222	GST C-terminal.|C-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	voltage-gated chloride channel activity	p.R222H(1)		large_intestine(1)|ovary(1)|skin(1)	3	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TAAATTCTTCACGGGCATAGG	0.413	Melanoma(108;581 1592 2289 21669 28822)		NA											15	136					0	0	0.00499	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186862291	186862291	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:186862291delG	uc001gsc.2	+	4	469	c.264delG	c.(262-264)GAGfs	p.E88fs	PLA2G4A_uc010pos.1_Frame_Shift_Del_p.E88fs	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	88	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ATGTTTTGGAGGTAAGTGAAC	0.373			NA											46	241	---	---	---	---	NA	NA	NA	NA	NA
KIF26B	55083	broad.mit.edu	37	1	245851437	245851437	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:245851437delC	uc001ibf.1	+	12	5592	c.5152delC	c.(5152-5154)CCCfs	p.P1718fs	KIF26B_uc001ibg.1_Frame_Shift_Del_p.P1336fs|KIF26B_uc001ibh.1_Frame_Shift_Del_p.P960fs	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1718	Ser-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CGGGACCTCGCCCCCCAGCTC	0.771			NA											4	7	---	---	---	---	NA	NA	NA	NA	NA
OR2T6	254879	broad.mit.edu	37	1	248551620	248551621	+	Frame_Shift_Ins	INS	-	-	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr1:248551620_248551621insT	uc001iei.1	+	1	711_712	c.711_712insT	c.(709-714)GCCTTTfs	p.A237fs		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	237_238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGAAGAAGGCCTTTGCCACCTG	0.505			NA											19	110	---	---	---	---	NA	NA	NA	NA	NA
OR56B1	387748	broad.mit.edu	37	11	5757967	5757967	+	Frame_Shift_Del	DEL	T	T	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:5757967delT	uc001mbt.1	+	1	221	c.221delT	c.(220-222)ATCfs	p.I74fs	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|OR56B1_uc001mbs.1_Frame_Shift_Del_p.I74fs|OR56B1_uc009yev.1_Frame_Shift_Del_p.I74fs	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		TTCCTTGGCATCCTCTGTATG	0.478			NA											15	52	---	---	---	---	NA	NA	NA	NA	NA
CHST1	8534	broad.mit.edu	37	11	45672154	45672154	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr11:45672154delC	uc001mys.1	-	4	991	c.320delG	c.(319-321)GGCfs	p.G107fs		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	107	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		CGGGCTCTTGCCCTGGGTGAA	0.627			NA											20	163	---	---	---	---	NA	NA	NA	NA	NA
KIAA0748	9840	broad.mit.edu	37	12	55357547	55357547	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr12:55357547delC	uc001sgn.3	-	8	744	c.634delG	c.(634-636)GACfs	p.D212fs	KIAA0748_uc001sgl.3_Frame_Shift_Del_p.D74fs|KIAA0748_uc001sgm.3_5'UTR|KIAA0748_uc010spb.1_Intron|KIAA0748_uc010spc.1_Frame_Shift_Del_p.D74fs|KIAA0748_uc010spd.1_Frame_Shift_Del_p.D212fs|KIAA0748_uc001sgo.3_Intron	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	212										ovary(1)|central_nervous_system(1)	2						AGGCAGGGGTCTTCCATTTCA	0.547			NA											17	16	---	---	---	---	NA	NA	NA	NA	NA
KL	9365	broad.mit.edu	37	13	33591005	33591005	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr13:33591005delG	uc001uus.2	+	1	435	c.427delG	c.(427-429)GGGfs	p.G143fs	KL_uc001uur.1_Intron	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	143	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GCGCGAGCTCGGGGTCACTCA	0.716			NA											25	32	---	---	---	---	NA	NA	NA	NA	NA
NOVA1	4857	broad.mit.edu	37	14	26918152	26918152	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:26918152delG	uc001wpy.2	-	5	855	c.537delC	c.(535-537)CCCfs	p.P179fs	NOVA1_uc001wpz.2_Frame_Shift_Del_p.P155fs|NOVA1_uc001wqa.2_Frame_Shift_Del_p.P57fs	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	182	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CTGTGCTGTTGGGAACTATAA	0.383			NA											15	126	---	---	---	---	NA	NA	NA	NA	NA
RPL10L	140801	broad.mit.edu	37	14	47120870	47120870	+	Frame_Shift_Del	DEL	G	G	-	rs141953926		TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr14:47120870delG	uc001wwg.2	-	1	159	c.70delC	c.(70-72)CGAfs	p.R24fs		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	24					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						GGAACCCCTCGGCAGAAACGA	0.542			NA											18	83	---	---	---	---	NA	NA	NA	NA	NA
TMEM62	80021	broad.mit.edu	37	15	43430790	43430790	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:43430790delG	uc001zqr.2	+	4	728	c.449delG	c.(448-450)AGTfs	p.S150fs	TMEM62_uc010bda.2_Frame_Shift_Del_p.S20fs	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	150						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		AATATTCCAAGTCTGGACAGC	0.308			NA											21	33	---	---	---	---	NA	NA	NA	NA	NA
SH3GL3	6457	broad.mit.edu	37	15	84237419	84237419	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:84237419delC	uc002bjw.2	+	4	521	c.326delC	c.(325-327)ACCfs	p.T109fs	SH3GL3_uc010uot.1_Frame_Shift_Del_p.T109fs|SH3GL3_uc002bjx.2_Frame_Shift_Del_p.T40fs|SH3GL3_uc002bju.2_Frame_Shift_Del_p.T117fs|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	109	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						GAAGACTCCACCTTTGGTGAG	0.502			NA											25	43	---	---	---	---	NA	NA	NA	NA	NA
AGBL1	123624	broad.mit.edu	37	15	86801251	86801251	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr15:86801251delG	uc002blz.1	+	8	900	c.820delG	c.(820-822)GGGfs	p.G274fs		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	274	Asp-rich.				C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TACTGAAGATGGGAAAGTGGA	0.433			NA											35	134	---	---	---	---	NA	NA	NA	NA	NA
IL21R	50615	broad.mit.edu	37	16	27455957	27455957	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:27455957delG	uc002doq.1	+	6	835	c.602delG	c.(601-603)CGGfs	p.R201fs	IL21R_uc002dor.1_Frame_Shift_Del_p.R201fs|IL21R_uc002dos.1_Frame_Shift_Del_p.R201fs	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	201	Extracellular (Potential).|Fibronectin type-III.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CTGCAGGTGCGGGCAGGGCCC	0.597			NA	T	BCL6	NHL								38	89	---	---	---	---	NA	NA	NA	NA	NA
NKD1	85407	broad.mit.edu	37	16	50667134	50667135	+	Frame_Shift_Ins	INS	-	-	C			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr16:50667134_50667135insC	uc002egg.1	+	10	1079_1080	c.855_856insC	c.(853-858)CTGCCCfs	p.L285fs		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	285_286					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		AGTCAGAACTGCCCCCCCGCAC	0.485			NA											7	68	---	---	---	---	NA	NA	NA	NA	NA
COG1	9382	broad.mit.edu	37	17	71204463	71204464	+	Frame_Shift_Ins	INS	-	-	G			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr17:71204463_71204464insG	uc002jjg.2	+	14	2852_2853	c.2816_2817insG	c.(2815-2817)CCGfs	p.P939fs	COG1_uc002jjh.2_3'UTR|COG1_uc002jjf.1_3'UTR|FAM104A_uc002jjj.3_3'UTR|FAM104A_uc002jji.3_3'UTR	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	939					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			GTTGTCCCCCCGGCACGCTCCA	0.574			NA											34	47	---	---	---	---	NA	NA	NA	NA	NA
GRIN2D	2906	broad.mit.edu	37	19	48919404	48919404	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr19:48919404delC	uc002pjc.3	+	7	1815	c.1727delC	c.(1726-1728)GCCfs	p.A576fs		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	576	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	TCCCCCTCGGCCTTCCTCGGT	0.547			NA											12	41	---	---	---	---	NA	NA	NA	NA	NA
GALM	130589	broad.mit.edu	37	2	38908485	38908487	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	GAA	GAA	-	-	GAA	GAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:38908485_38908487delGAA	uc002rqy.2	+	3	661_663	c.409_411delGAA	c.(409-411)GAAdel	p.E138del		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	138					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				TCCAGATGGTGAAGAAGGCTACC	0.532			NA											8	199	---	---	---	---	NA	NA	NA	NA	NA
LRRTM4	80059	broad.mit.edu	37	2	77745528	77745528	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:77745528delC	uc002snr.2	-	3	1882	c.1467delG	c.(1465-1467)AAGfs	p.K489fs	LRRTM4_uc002snq.2_Frame_Shift_Del_p.K489fs|LRRTM4_uc002sns.2_Frame_Shift_Del_p.K489fs|LRRTM4_uc002snt.2_Frame_Shift_Del_p.K490fs	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	489	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		AGTTTGTAGGCTTGTAGTCCA	0.463			NA											17	26	---	---	---	---	NA	NA	NA	NA	NA
THSD7B	80731	broad.mit.edu	37	2	138169367	138169367	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:138169367delG	uc002tva.1	+	13	2791	c.2791delG	c.(2791-2793)GGCfs	p.G931fs	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Frame_Shift_Del_p.G821fs	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATGTGGAGAAGGCCTGCGCTT	0.512			NA											17	51	---	---	---	---	NA	NA	NA	NA	NA
HJURP	55355	broad.mit.edu	37	2	234746241	234746242	+	Frame_Shift_Ins	INS	-	-	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr2:234746241_234746242insA	uc002vvg.2	-	9	2294_2295	c.2228_2229insT	c.(2227-2229)TTGfs	p.L743fs	HJURP_uc010znd.1_Frame_Shift_Ins_p.L682fs|HJURP_uc010zne.1_Frame_Shift_Ins_p.L651fs	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	743					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		TTTTAGTTTCCAATTTTTCTAG	0.332			NA											11	64	---	---	---	---	NA	NA	NA	NA	NA
MN1	4330	broad.mit.edu	37	22	28192956	28192956	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr22:28192956delC	uc003adj.2	-	1	4531	c.3576delG	c.(3574-3576)GCGfs	p.A1192fs		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1192							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CGCCATTCTGCGCCCCTGAGG	0.647			NA	T	ETV6	AML|meningioma								10	13	---	---	---	---	NA	NA	NA	NA	NA
OR5H1	26341	broad.mit.edu	37	3	97852271	97852272	+	Frame_Shift_Ins	INS	-	-	A			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:97852271_97852272insA	uc011bgt.1	+	1	730_731	c.730_731insA	c.(730-732)CATfs	p.H244fs		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CTGTGGAGCCCATCTCTTCTCT	0.411			NA											26	42	---	---	---	---	NA	NA	NA	NA	NA
ABI3BP	25890	broad.mit.edu	37	3	100645145	100645145	+	Splice_Site	DEL	C	C	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr3:100645145delC	uc003dun.2	-	2	365	c.280_splice	c.e2+1	p.D94_splice	ABI3BP_uc003duo.2_Splice_Site_p.D87_splice|ABI3BP_uc003dup.3_Splice_Site_p.D87_splice	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein							extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						AAACACCTTACCAACTATAGC	0.453			NA											20	37	---	---	---	---	NA	NA	NA	NA	NA
MEGF10	84466	broad.mit.edu	37	5	126732373	126732373	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr5:126732373delG	uc003kuh.3	+	7	924	c.562delG	c.(562-564)GGTfs	p.G188fs	MEGF10_uc010jdc.1_Frame_Shift_Del_p.G188fs|MEGF10_uc010jdd.1_Frame_Shift_Del_p.G188fs|MEGF10_uc003kui.3_Frame_Shift_Del_p.G188fs	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	188	Extracellular (Potential).|EGF-like 3.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		GGGCACCTATGGTAACGACTG	0.632			NA											28	35	---	---	---	---	NA	NA	NA	NA	NA
SEMA3E	9723	broad.mit.edu	37	7	83029344	83029345	+	Frame_Shift_Ins	INS	-	-	T			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chr7:83029344_83029345insT	uc003uhy.1	-	11	1831_1832	c.1365_1366insA	c.(1363-1368)ACAGATfs	p.T455fs		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	455_456	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				GTCTCTTTACCTGTCCCAATAA	0.337			NA											48	119	---	---	---	---	NA	NA	NA	NA	NA
RBBP7	5931	broad.mit.edu	37	X	16870709	16870709	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:16870709delG	uc004cxt.2	-	8	1286	c.928delC	c.(928-930)CATfs	p.H310fs	RBBP7_uc004cxs.1_Frame_Shift_Del_p.H354fs|RBBP7_uc004cxu.2_Frame_Shift_Del_p.H301fs|RBBP7_uc010nez.2_3'UTR	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	310	WD 5.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					TCGAAGGTATGGAGTTTTAAT	0.328			NA											21	111	---	---	---	---	NA	NA	NA	NA	NA
FAM48B1	100130302	broad.mit.edu	37	X	24381860	24381860	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4631-01A-01D-1753-08	TCGA-38-4631-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3ffc36d-b0b8-4ada-a00a-b48890c0162c	84b00131-cbbe-461f-a006-5277e14b05f9	g.chrX:24381860delG	uc011mjx.1	+	1	983	c.983delG	c.(982-984)TGGfs	p.W328fs		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						CTCCCAGTCTGGCCAGCCCAG	0.552			NA											47	141	---	---	---	---	NA	NA	NA	NA	NA