Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNFRSF4	7293	broad.mit.edu	37	1	1147438	1147438	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:1147438G>C	uc001ade.2	-	5	523	c.518C>G	c.(517-519)GCC>GGC	p.A173G	TNFRSF4_uc001adf.2_Missense_Mutation_p.A177G	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	173	Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGGCTGCGTGGCTGGGGGGTC	0.687			NA											5	16					0	0	0.001168	0	0
KIF1B	23095	broad.mit.edu	37	1	10423341	10423341	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:10423341G>T	uc001aqx.3	+	41	4507	c.4305G>T	c.(4303-4305)TCG>TCT	p.S1435S	KIF1B_uc001aqw.3_Silent_p.S1389S|KIF1B_uc001aqy.2_Silent_p.S1409S|KIF1B_uc001aqz.2_Silent_p.S1435S|KIF1B_uc001ara.2_Silent_p.S1395S|KIF1B_uc001arb.2_Silent_p.S1421S	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1435					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CTTCAAATAGGAATCGAGTCA	0.363			NA											7	29					0.000442599	0.000490831	0.006214	1	0
LOC440563	440563	broad.mit.edu	37	1	13183522	13183522	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:13183522C>A	uc010obg.1	-	1	446	c.351G>T	c.(349-351)CGG>CGT	p.R117R		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	117						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CATAATAATCCCGTTGAAAGC	0.522			NA											17	75					3.45872e-05	4.04296e-05	0.004007	1	0
TAS1R2	80834	broad.mit.edu	37	1	19186125	19186125	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:19186125G>A	uc001bba.1	-	1	31	c.30C>T	c.(28-30)TCC>TCT	p.S10S		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	10					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GGAAGAACAGGGAGGAGATGG	0.587			NA											6	48					0	0	0.001984	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19199453	19199453	+	Splice_Site	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:19199453T>A	uc001bbb.2	-	15	1856	c.1580_splice	c.e15-1	p.G527_splice	ALDH4A1_uc010ocu.1_Intron|ALDH4A1_uc001bbc.2_Intron	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor						proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	CATTGGTTCCTGCGGAAAAGA	0.567			NA											8	46					0	0	0.00308	0	0
SERINC2	347735	broad.mit.edu	37	1	31898638	31898638	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:31898638G>C	uc010ogh.1	+	5	701	c.500G>C	c.(499-501)GGC>GCC	p.G167A	SERINC2_uc010ogg.1_Missense_Mutation_p.G164A|SERINC2_uc009vtw.1_Silent_p.R136R|SERINC2_uc001bst.2_Missense_Mutation_p.G163A|SERINC2_uc001bsu.2_Missense_Mutation_p.G108A|SERINC2_uc001bsv.2_Missense_Mutation_p.G108A	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	163	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		TTCTACTTCGGCGTCGTGGGC	0.507			NA											34	115					0	0	0.003271	0	0
LRRC42	115353	broad.mit.edu	37	1	54427706	54427706	+	Splice_Site	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:54427706G>T	uc001cwj.1	+	5	925	c.725_splice	c.e5-1	p.C242_splice	LRRC42_uc001cwl.1_Splice_Site_p.C242_splice|LRRC42_uc001cwk.1_Splice_Site_p.C242_splice|LRRC42_uc009vzm.1_Splice_Site_p.C242_splice	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42												0						TTGACATCTAGGTAACCCTGA	0.378			NA											9	24					2.17888e-05	2.56426e-05	0.006214	1	0
LHX8	431707	broad.mit.edu	37	1	75596413	75596413	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:75596413G>C	uc001dgo.2	+	2	678	c.14G>C	c.(13-15)AGC>ACC	p.S5T	uc001dgp.1_RNA	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	5						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CAGATTCTGAGCAGGGTAAGT	0.448			NA											14	67					0	0	0.004007	0	0
AK5	26289	broad.mit.edu	37	1	77806129	77806129	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:77806129A>G	uc001dhn.2	+	6	1024	c.767A>G	c.(766-768)AAG>AGG	p.K256R	AK5_uc001dho.2_Missense_Mutation_p.K230R	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	256					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						AGATTACTGAAGCGTGCAGAA	0.453			NA											17	60					0	0	0.007413	0	0
PTGFR	5737	broad.mit.edu	37	1	79002247	79002247	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:79002247G>T	uc001din.2	+	3	1221	c.955G>T	c.(955-957)GCC>TCC	p.A319S	PTGFR_uc001dim.2_3'UTR	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	319	Cytoplasmic (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CTATAAGCTTGCCAGTCAATG	0.393			NA											9	40					2.17888e-05	2.56426e-05	0.006214	1	0
GBP3	2635	broad.mit.edu	37	1	89477519	89477519	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:89477519G>T	uc001dmt.2	-	7	1265	c.1060C>A	c.(1060-1062)CTG>ATG	p.L354M	GBP3_uc010oss.1_Missense_Mutation_p.L275M|GBP3_uc001dmu.2_Missense_Mutation_p.L220M|GBP3_uc001dmv.2_Intron	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	354						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		ACCCTGTGCAGGTCCAGCAGC	0.502			NA											24	54					5.35356e-11	7.5298e-11	0.00278	1	0
GFI1	2672	broad.mit.edu	37	1	92948583	92948583	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:92948583C>A	uc001dou.3	-	3	300	c.136G>T	c.(136-138)GGG>TGG	p.G46W	GFI1_uc001dov.3_Missense_Mutation_p.G46W|GFI1_uc001dow.3_Missense_Mutation_p.G46W	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	46					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		GCCTTCGCCCCGCCTGCATTT	0.657			NA											3	45					1.23904e-05	1.47322e-05	0.000602	1	0
C1orf88	128344	broad.mit.edu	37	1	111892810	111892810	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:111892810G>C	uc001eaw.2	+	5	552	c.472G>C	c.(472-474)GTT>CTT	p.V158L	C1orf88_uc001eax.2_Missense_Mutation_p.V125L|C1orf88_uc009wge.1_Missense_Mutation_p.G81A|C1orf88_uc001eay.2_Missense_Mutation_p.V71L	NM_181643	NP_857594	Q8TCI5	CA088_HUMAN	hypothetical protein LOC128344	158										ovary(1)|skin(1)	2		all_cancers(81;3.21e-05)|all_epithelial(167;1.19e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|Colorectal(144;0.0301)|all cancers(265;0.0677)|Epithelial(280;0.0897)|COAD - Colon adenocarcinoma(174;0.116)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGGGCTCAGGTTCCATGTCT	0.398			NA											24	101					0	0	0.00278	0	0
TBX15	6913	broad.mit.edu	37	1	119427921	119427921	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:119427921C>A	uc001ehl.1	-	8	1240	c.925G>T	c.(925-927)GGG>TGG	p.G309W	TBX15_uc009whj.1_Missense_Mutation_p.G133W	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	415						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TCACTCAGCCCTGGGTAGCTC	0.537			NA											19	32					1.56452e-12	2.30351e-12	0.007413	1	0
LCE1B	353132	broad.mit.edu	37	1	152785055	152785055	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:152785055A>G	uc001faq.2	+	1	609	c.133A>G	c.(133-135)AGT>GGT	p.S45G		NM_178349	NP_848126	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	45					keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCCTGCTGCAGTGTCAGCTC	0.522			NA											29	198					0	0	0.008361	0	0
S100A8	6279	broad.mit.edu	37	1	153362715	153362715	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:153362715T>C	uc001fbs.2	-	3	201	c.146A>G	c.(145-147)AAG>AGG	p.K49R		NM_002964	NP_002955	P05109	S10A8_HUMAN	S100 calcium-binding protein A8	49	EF-hand 2.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTGCACCCTTTTTCTGTCA	0.507			NA											4	169					0	0	0.000602	0	0
SHC1	6464	broad.mit.edu	37	1	154942963	154942963	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:154942963G>A	uc001ffv.2	-	1	261	c.40C>T	c.(40-42)CGG>TGG	p.R14W	SHC1_uc001ffz.1_5'Flank|SHC1_uc001ffw.2_Missense_Mutation_p.R14W|SHC1_uc001ffx.2_Intron|SHC1_uc001ffy.2_Intron	NM_183001	NP_892113	P29353	SHC1_HUMAN	SHC-transforming protein 1 isoform 1	14					activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(1)|skin(1)	2	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GACTCATTCCGGAGTGGATTG	0.642	NSCLC(4;32 234 1864 2492 3259 13747 17376)		NA											10	144					0	0	0.008291	0	0
C1orf129	80133	broad.mit.edu	37	1	170931105	170931105	+	Silent	SNP	A	A	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:170931105A>C	uc001ghg.2	+	6	493	c.363A>C	c.(361-363)CTA>CTC	p.L121L	C1orf129_uc009wvy.2_5'UTR|C1orf129_uc010plz.1_Silent_p.L121L	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	121							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCTACAAACTACAGATCTTAA	0.308			NA											4	16					0	0	0.000602	0	0
CRB1	23418	broad.mit.edu	37	1	197396748	197396748	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:197396748G>T	uc001gtz.2	+	7	2428	c.2293G>T	c.(2293-2295)GTC>TTC	p.V765F	CRB1_uc010poz.1_Missense_Mutation_p.V696F|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.V653F|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.V246F|CRB1_uc001gub.1_Missense_Mutation_p.V414F	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	765	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ATATATCCGTGTCTGGCTAGA	0.428			NA											10	25					9.70103e-10	1.33727e-09	0.008291	1	0
PKP1	5317	broad.mit.edu	37	1	201291167	201291167	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:201291167C>A	uc001gwd.2	+	9	1723	c.1472C>A	c.(1471-1473)CCC>CAC	p.P491H	PKP1_uc001gwe.2_Missense_Mutation_p.P470H|PKP1_uc009wzm.2_Missense_Mutation_p.P78H	NM_000299	NP_000290	Q13835	PKP1_HUMAN	plakophilin 1 isoform 1b	491					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			ovary(2)	2						GCCGAGGTGCCCACCCGCTAC	0.607			NA											16	39					0.00316338	0.00340975	0.003163	1	0
OPTC	26254	broad.mit.edu	37	1	203472092	203472092	+	Silent	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:203472092T>C	uc001gzu.1	+	6	899	c.783T>C	c.(781-783)TCT>TCC	p.S261S		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	261	LRR 4.					proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			TGCTGGATTCTATCCCGGGGC	0.557			NA											12	47					0	0	0.000978	0	0
NFASC	23114	broad.mit.edu	37	1	204948500	204948500	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:204948500C>T	uc001hbj.2	+	19	2317	c.1989C>T	c.(1987-1989)GTC>GTT	p.V663V	NFASC_uc010pra.1_Silent_p.V659V|NFASC_uc001hbi.2_Silent_p.V659V|NFASC_uc010prb.1_Silent_p.V674V|NFASC_uc010prc.1_Silent_p.V230V|NFASC_uc001hbk.1_Silent_p.V469V|NFASC_uc001hbl.1_5'Flank	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	663	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACTACGTCGTCCAGTTTGAAG	0.458			NA											40	68					0	0	0.006999	0	0
KCNH1	3756	broad.mit.edu	37	1	210857201	210857201	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:210857201C>T	uc001hib.2	-	11	2562	c.2392G>A	c.(2392-2394)GTA>ATA	p.V798I	KCNH1_uc001hic.2_Missense_Mutation_p.V771I	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	798	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TGGAAGGATACGGGCGTGGCA	0.662			NA											12	123					0	0	0.001368	0	0
KCNK2	3776	broad.mit.edu	37	1	215342574	215342574	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:215342574G>A	uc001hkq.2	+	4	677	c.508G>A	c.(508-510)GGC>AGC	p.G170S	KCNK2_uc001hko.2_Missense_Mutation_p.G166S|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.G155S	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	170							outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CACAGAAGGCGGCAAAATATT	0.269			NA											6	44					0	0	0.001168	0	0
USH2A	7399	broad.mit.edu	37	1	215813954	215813954	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:215813954G>T	uc001hku.1	-	68	15301	c.14914C>A	c.(14914-14916)CGC>AGC	p.R4972S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4972	Fibronectin type-III 35.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGTACACGCGTCGCCCTCCG	0.542			NA								HNSCC(13;0.011)			13	38					7.03913e-09	9.40362e-09	0.001368	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227268619	227268619	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:227268619C>A	uc001hqr.2	-	17	3398	c.2455G>T	c.(2455-2457)GCC>TCC	p.A819S	CDC42BPA_uc001hqq.2_Missense_Mutation_p.A83S|CDC42BPA_uc001hqs.2_Missense_Mutation_p.A738S|CDC42BPA_uc009xes.2_Missense_Mutation_p.A819S|CDC42BPA_uc010pvs.1_Missense_Mutation_p.A819S|CDC42BPA_uc001hqp.2_5'UTR|CDC42BPA_uc001hqu.1_5'UTR	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	819	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				GTGATTTGGGCTTCCCAATGT	0.388			NA											14	139					4.36969e-10	6.07194e-10	0.001855	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227348297	227348297	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:227348297G>C	uc001hqr.2	-	6	1583	c.640C>G	c.(640-642)CAT>GAT	p.H214D	CDC42BPA_uc001hqs.2_Missense_Mutation_p.H214D|CDC42BPA_uc009xes.2_Missense_Mutation_p.H214D|CDC42BPA_uc010pvs.1_Missense_Mutation_p.H214D	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	214	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				AACCGAATATGTCCATTCATA	0.299			NA											71	56					0	0	0.00361	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232534943	232534943	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:232534943G>T	uc001hvg.2	-	21	5257	c.5099C>A	c.(5098-5100)TCC>TAC	p.S1700Y	SIPA1L2_uc001hvf.2_Missense_Mutation_p.S756Y	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1700	Potential.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CGCGGTCTGGGACTCCTCCTG	0.502			NA											4	44					0.000602214	0.000665707	0.000602	1	0
RYR2	6262	broad.mit.edu	37	1	237995907	237995907	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:237995907G>T	uc001hyl.1	+	105	14984	c.14864G>T	c.(14863-14865)GGG>GTG	p.G4955V	RYR2_uc010pyb.1_3'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4955					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCCCAGCAGGGGATTGCTTC	0.413			NA											6	16					0.00116845	0.00127534	0.001168	1	0
WDR64	128025	broad.mit.edu	37	1	241901781	241901781	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:241901781G>C	uc001hze.1	+	10	1488	c.1281G>C	c.(1279-1281)ATG>ATC	p.M427I	WDR64_uc001hzf.1_Missense_Mutation_p.M147I			B1ANS9	WDR64_HUMAN	RecName: Full=WD repeat-containing protein 64;	427	WD 5.									skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			ATCATGGCATGCTTATTACGG	0.368			NA											7	22					0	0	0.001984	0	0
WDR64	128025	broad.mit.edu	37	1	241904880	241904880	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:241904880C>A	uc001hze.1	+	11	1561	c.1354C>A	c.(1354-1356)CAC>AAC	p.H452N	WDR64_uc001hzf.1_Missense_Mutation_p.H172N			B1ANS9	WDR64_HUMAN	RecName: Full=WD repeat-containing protein 64;	452										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			ACAGGTTCCTCACACTCATGA	0.343			NA											11	20					0.00829132	0.00879999	0.008291	1	0
WDR64	128025	broad.mit.edu	37	1	241907716	241907716	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:241907716C>A	uc001hze.1	+	12	1669	c.1462C>A	c.(1462-1464)CTC>ATC	p.L488I	WDR64_uc001hzf.1_Missense_Mutation_p.L208I			B1ANS9	WDR64_HUMAN	RecName: Full=WD repeat-containing protein 64;	488	WD 6.									skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CGAGACTGGGCTCCAAGTATA	0.398			NA											12	41					5.50884e-06	6.64132e-06	0.001368	1	0
OR2C3	81472	broad.mit.edu	37	1	247695565	247695565	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr1:247695565C>A	uc009xgy.2	-	2	611	c.249G>T	c.(247-249)CTG>CTT	p.L83L	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			AGAGGTTAGCCAGGAGCTGTG	0.542			NA											15	39					2.32078e-09	3.16138e-09	0.003163	1	0
ITIH5	80760	broad.mit.edu	37	10	7621754	7621754	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:7621754A>T	uc001ijq.2	-	9	1461	c.1382T>A	c.(1381-1383)GTG>GAG	p.V461E	ITIH5_uc001ijp.2_Missense_Mutation_p.V247E|ITIH5_uc001ijr.1_Missense_Mutation_p.V461E	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	461	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CTCCTCGTGCACGCGCCGTGT	0.622			NA											13	95					0	0	0.001855	0	0
SLC39A12	221074	broad.mit.edu	37	10	18250582	18250582	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:18250582C>G	uc001ipo.2	+	3	607	c.334C>G	c.(334-336)CAG>GAG	p.Q112E	SLC39A12_uc001ipn.2_Missense_Mutation_p.Q112E|SLC39A12_uc001ipp.2_Missense_Mutation_p.Q112E|SLC39A12_uc010qck.1_5'UTR	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	112	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AGAAGTGGTCCAGAGAGTTTC	0.348			NA											25	51					0	0	0.003954	0	0
ARMC3	219681	broad.mit.edu	37	10	23321943	23321943	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:23321943G>T	uc001irm.3	+	18	2483	c.2400G>T	c.(2398-2400)TTG>TTT	p.L800F	ARMC3_uc010qcv.1_Missense_Mutation_p.L793F|ARMC3_uc010qcw.1_Missense_Mutation_p.L537F	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	800							binding				0						ATCGAGCTTTGCTTTTCAAGG	0.363			NA											5	53					0.00198382	0.002145	0.001984	1	0
LOC387646	387646	broad.mit.edu	37	10	27538184	27538184	+	Silent	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:27538184A>T	uc001its.2	-	1	3052	c.1209T>A	c.(1207-1209)TCT>TCA	p.S403S		NR_003525				SubName: Full=cDNA FLJ44924 fis, clone BRAMY3014555;												0						CCGTGGTTGGAGACGGTTTAA	0.532			NA											51	193					0	0	0.00361	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702213	27702213	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:27702213G>T	uc001itu.2	-	1	1085	c.967C>A	c.(967-969)CGG>AGG	p.R323R		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	323					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TACAGCAGCCGCATGGCTTTG	0.562			NA											59	116					1.93748e-29	3.1771e-29	0.00361	1	0
ITGB1	3688	broad.mit.edu	37	10	33217116	33217116	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:33217116C>A	uc001iws.3	-	5	589	c.453G>T	c.(451-453)CTG>CTT	p.L151L	ITGB1_uc001iwp.3_Silent_p.L151L|ITGB1_uc001iwq.3_Silent_p.L151L|ITGB1_uc001iwr.3_Silent_p.L151L|ITGB1_uc001iwt.3_Silent_p.L151L|ITGB1_uc001iwu.1_Silent_p.L151L	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	151	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTGAGTAAGACAGGTCCATAA	0.378			NA											15	102					0.000308642	0.000344484	0.003163	1	0
GDF2	2658	broad.mit.edu	37	10	48413613	48413613	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:48413613C>T	uc001jfa.1	-	2	1418	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	419					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						CTCATGCCCTCGTAATGGTAC	0.617			NA											9	12					0	0	0.006214	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332454	71332454	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:71332454C>A	uc001jpp.2	-	2	504	c.346G>T	c.(346-348)GAC>TAC	p.D116Y		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	116	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						AGCTTCGCGTCGTCTGGGAAG	0.622			NA											7	43					8.12818e-05	9.22083e-05	0.001984	1	0
NEUROG3	50674	broad.mit.edu	37	10	71332668	71332668	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:71332668C>T	uc001jpp.2	-	2	290	c.132G>A	c.(130-132)GGG>GGA	p.G44G		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	44					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						CTGCGCAGTTCCCCCGTGTGC	0.711			NA											14	22					0	0	0.00245	0	0
DYDC1	143241	broad.mit.edu	37	10	82102070	82102070	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:82102070C>T	uc001kbx.2	-	5	462	c.297G>A	c.(295-297)AGG>AGA	p.R99R	DYDC1_uc001kby.1_Silent_p.R99R|DYDC1_uc009xsr.1_Silent_p.R99R|DYDC2_uc001kbz.1_5'Flank|DYDC2_uc001kca.1_5'Flank	NM_138812	NP_620167	Q8WWB3	DYDC1_HUMAN	DPY30 domain containing 1	99											0			Colorectal(32;0.229)			GTATTCTCTGCCTCTCCTTTT	0.323			NA											12	53					0	0	0.000978	0	0
MYOF	26509	broad.mit.edu	37	10	95129512	95129512	+	Missense_Mutation	SNP	C	C	T	rs149848851	by1000genomes	TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:95129512C>T	uc001kin.2	-	25	2602	c.2479G>A	c.(2479-2481)GGG>AGG	p.G827R	MYOF_uc001kio.2_Missense_Mutation_p.G814R|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	827	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						ACCTTTGGCCCGTTGTTTTTC	0.443			NA											6	27					0	0	0.001168	0	0
TACC2	10579	broad.mit.edu	37	10	123976300	123976300	+	Silent	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:123976300G>C	uc001lfv.2	+	11	7863	c.7503G>C	c.(7501-7503)CTG>CTC	p.L2501L	TACC2_uc001lfw.2_Silent_p.L647L|TACC2_uc009xzx.2_Silent_p.L2456L|TACC2_uc010qtv.1_Silent_p.L2505L|TACC2_uc001lfx.2_Silent_p.L205L|TACC2_uc001lfy.2_Silent_p.L201L|TACC2_uc001lfz.2_Silent_p.L579L|TACC2_uc001lga.2_Silent_p.L579L|TACC2_uc009xzy.2_Silent_p.L591L|TACC2_uc001lgb.2_Silent_p.L536L|TACC2_uc010qtw.1_Silent_p.L596L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2501						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCTCGGACCTGTCCACCTTTG	0.562			NA											25	80					0	0	0.00333	0	0
MKI67	4288	broad.mit.edu	37	10	129900995	129900995	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:129900995C>T	uc001lke.2	-	13	9304	c.9109G>A	c.(9109-9111)GCA>ACA	p.A3037T	MKI67_uc001lkf.2_Missense_Mutation_p.A2677T|MKI67_uc009yav.1_Missense_Mutation_p.A2612T|MKI67_uc009yaw.1_Missense_Mutation_p.A2187T	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	3037	ATP (Potential).				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTGCCTCTTGCCCTGGGAGCA	0.537			NA											4	90					0	0	0.009096	0	0
TCERG1L	256536	broad.mit.edu	37	10	132965122	132965122	+	Missense_Mutation	SNP	C	C	T	rs145806750	by1000genomes	TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:132965122C>T	uc001lkp.2	-	5	969	c.883G>A	c.(883-885)GCC>ACC	p.A295T	TCERG1L_uc009yax.1_RNA	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	295										large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		GGAGGGCGGGCCACTCGGCCC	0.512			NA											10	29					0	0	0.008291	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629050	1629050	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:1629050C>A	uc001ltw.1	-	1	644	c.566G>T	c.(565-567)TGC>TTC	p.C189F		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	189	11 X 4 AA repeats of C-C-X-P.|8.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		gggtttgcagcagctggactg	0.1			NA											110	226					3.35719e-51	5.72211e-51	0.00361	1	0
OR51A4	401666	broad.mit.edu	37	11	4967817	4967817	+	Nonsense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:4967817T>A	uc010qys.1	-	1	514	c.514A>T	c.(514-516)AAG>TAG	p.K172*		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGTTTTTCTTGCAATATCTC	0.413			NA											24	223					0	0	0.00278	0	0
OR51A2	401667	broad.mit.edu	37	11	4976042	4976042	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:4976042C>A	uc010qyt.1	-	1	902	c.902G>T	c.(901-903)AGA>ATA	p.R301I		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AACTCTCACTCTAATCTGTTT	0.353			NA											50	28					8.99859e-20	1.4348e-19	0.00361	1	0
OR52N4	390072	broad.mit.edu	37	11	5776344	5776344	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:5776344A>G	uc001mbu.2	+	1	422	c.374A>G	c.(373-375)TAT>TGT	p.Y125C	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CTGGATCGCTATGTGGCCATC	0.488			NA											42	84					0	0	0.002522	0	0
OR52E6	390078	broad.mit.edu	37	11	5862466	5862466	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:5862466C>A	uc010qzq.1	-	1	662	c.662G>T	c.(661-663)AGG>ATG	p.R221M	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATAGAGGATCCTGATATGGGA	0.463			NA											10	31					0.00621372	0.00663563	0.006214	1	0
PRKCDBP	112464	broad.mit.edu	37	11	6341340	6341340	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:6341340G>A	uc001mcu.1	-	1	401	c.367C>T	c.(367-369)CAC>TAC	p.H123Y		NM_145040	NP_659477	Q969G5	PRDBP_HUMAN	protein kinase C, delta binding protein	123											0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCAGAACGTGGAGCTTCCCG	0.706			NA											3	18					0	0	0.009096	0	0
DCHS1	8642	broad.mit.edu	37	11	6648071	6648071	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:6648071G>A	uc001mem.1	-	14	6609	c.6199C>T	c.(6199-6201)CGC>TGC	p.R2067C		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2067	Cadherin 19.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGGGGAAAGCGGGGTCCACGC	0.597			NA											9	25					0	0	0.006214	0	0
NLRP14	338323	broad.mit.edu	37	11	7065050	7065050	+	Missense_Mutation	SNP	C	C	A	rs148807230		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:7065050C>A	uc001mfb.1	+	4	2116	c.1793C>A	c.(1792-1794)GCA>GAA	p.A598E		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	598					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATAAGCCAGGCAATGAGATGT	0.408			NA											28	55					6.38683e-12	9.24621e-12	0.008361	1	0
PTPN5	84867	broad.mit.edu	37	11	18764013	18764013	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:18764013G>T	uc001mpd.2	-	7	952	c.521C>A	c.(520-522)ACC>AAC	p.T174N	PTPN5_uc001mpb.2_Missense_Mutation_p.T142N|PTPN5_uc001mpc.2_Missense_Mutation_p.T174N|PTPN5_uc001mpe.2_Missense_Mutation_p.T142N|PTPN5_uc010rdj.1_Missense_Mutation_p.T118N|PTPN5_uc001mpf.2_Missense_Mutation_p.T150N|PTPN5_uc010rdk.1_Missense_Mutation_p.T119N	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	174						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						GGGCAGTGGGGTGGGTGGCTC	0.632			NA											19	52					1.10923e-09	1.52299e-09	0.00278	1	0
E2F8	79733	broad.mit.edu	37	11	19252381	19252381	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:19252381C>A	uc001mpm.2	-	8	1589	c.1067G>T	c.(1066-1068)GGC>GTC	p.G356V	E2F8_uc009yhv.2_Intron|E2F8_uc001mpn.3_Missense_Mutation_p.G356V	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	356					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TGGGCTGGAGCCTGAAACAGA	0.403			NA											11	24					4.68919e-08	6.12249e-08	0.008291	1	0
BDNF	627	broad.mit.edu	37	11	27680088	27680088	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:27680088C>T	uc010rdu.1	-	2	875	c.24G>A	c.(22-24)ATG>ATA	p.M8I	BDNFOS_uc001mrm.2_Intron|BDNFOS_uc009yij.2_RNA|BDNFOS_uc009yik.2_Intron|BDNFOS_uc009yil.2_RNA|BDNFOS_uc001mrp.2_Intron|BDNFOS_uc009yim.2_RNA|BDNFOS_uc009yin.2_Intron|BDNFOS_uc009yio.2_RNA|BDNFOS_uc009yip.2_RNA|BDNFOS_uc001mrn.2_Intron|BDNFOS_uc009yiq.2_RNA|BDNFOS_uc001mro.2_Intron|BDNFOS_uc009yir.2_RNA|BDNFOS_uc009yis.2_Intron|BDNFOS_uc009yit.2_Intron|BDNFOS_uc009yiu.2_RNA|BDNFOS_uc009yiv.2_Intron|BDNFOS_uc009yiw.2_RNA|BDNFOS_uc009yix.2_Intron|BDNFOS_uc009yiy.2_RNA|BDNFOS_uc009yiz.2_RNA|BDNFOS_uc001mrq.3_Intron|BDNFOS_uc001mrr.3_Intron|BDNFOS_uc009yja.2_Intron|BDNFOS_uc009yjb.2_RNA|BDNF_uc010rdv.1_Missense_Mutation_p.M8I|BDNF_uc001mrt.2_Missense_Mutation_p.M23I|BDNF_uc010rdw.1_Missense_Mutation_p.M8I|BDNF_uc009yjd.2_Missense_Mutation_p.M8I|BDNF_uc001mru.2_Missense_Mutation_p.M8I|BDNF_uc010rdx.1_Missense_Mutation_p.M8I|BDNF_uc010rdy.1_Missense_Mutation_p.M8I|BDNF_uc009yjg.2_Missense_Mutation_p.M8I|BDNF_uc009yje.2_Missense_Mutation_p.M90I|BDNF_uc009yjf.2_Missense_Mutation_p.M37I|BDNF_uc001mrv.2_Missense_Mutation_p.M8I|BDNF_uc001mrw.3_Missense_Mutation_p.M8I|BDNF_uc001mrx.2_Missense_Mutation_p.M8I|BDNF_uc001mry.3_Missense_Mutation_p.M8I|BDNF_uc001mrz.3_Missense_Mutation_p.M8I|BDNF_uc001msa.2_Missense_Mutation_p.M16I	NM_001143816	NP_001137288	P23560	BDNF_HUMAN	brain-derived neurotrophic factor isoform a	8						extracellular region	growth factor activity				0						ATGAAATAACCATAGTAAGGA	0.493			NA											31	84					0	0	0.002445	0	0
OR5D16	390144	broad.mit.edu	37	11	55607071	55607071	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:55607071G>T	uc010rio.1	+	1	844	c.844G>T	c.(844-846)GTG>TTG	p.V282L		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V282M(1)		ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GTTTTACACCGTGGTGATCCC	0.413			NA											13	52					0.000151284	0.00017106	0.001855	1	0
OR8K1	390157	broad.mit.edu	37	11	56113889	56113889	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:56113889C>A	uc010rjg.1	+	1	375	c.375C>A	c.(373-375)GCC>GCA	p.A125A		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	125	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CAGCAATGGCCTATGATCGCT	0.403			NA								HNSCC(65;0.19)			46	116					5.2432e-18	8.32178e-18	0.00361	1	0
OR9G9	504191	broad.mit.edu	37	11	56468517	56468517	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:56468517C>T	uc010rjn.1	+	1	654	c.654C>T	c.(652-654)CTC>CTT	p.L218L		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTCCTACCTCTTTATCATCA	0.527			NA											9	178					0	0	0.004007	0	0
SYT7	9066	broad.mit.edu	37	11	61300564	61300564	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:61300564G>C	uc001nrv.2	-	4	254	c.248C>G	c.(247-249)GCC>GGC	p.A83G	SYT7_uc009ynr.2_Missense_Mutation_p.A158G	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	83	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						TGGCACGGGGGCTGTGTTCAC	0.662			NA											12	51					0	0	0.00245	0	0
SCGB1D4	404552	broad.mit.edu	37	11	62065047	62065047	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:62065047C>T	uc001ntd.1	-	2	193	c.139G>A	c.(139-141)GCC>ACC	p.A47T		NM_206998	NP_996881	Q6XE38	SG1D4_HUMAN	secretoglobin family 1D member 4 precursor	47						extracellular region	binding				0						TTAAGTTTGGCAACTTGGAGG	0.448			NA											29	147					0	0	0.005443	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65721153	65721153	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:65721153G>A	uc001ogk.1	+	7	1299	c.1267G>A	c.(1267-1269)GCA>ACA	p.A423T	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_RNA	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	423	Potential.										0						GGCAGCCTACGCACCCAGAGG	0.741			NA											21	28					0	0	0.008871	0	0
NUDT8	254552	broad.mit.edu	37	11	67396390	67396390	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:67396390C>T	uc001omo.1	-	2	346	c.327G>A	c.(325-327)CCG>CCA	p.P109P	NUDT8_uc001omn.2_Silent_p.P109P	NM_181843	NP_862826	Q8WV74	NUDT8_HUMAN	nudix-type motif 8	109	Nudix hydrolase.					mitochondrion	hydrolase activity|metal ion binding				0						AGTGGCTTACCGGATCATACA	0.662			NA											18	54					0	0	0.007413	0	0
LRRC32	2615	broad.mit.edu	37	11	76371795	76371795	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:76371795G>T	uc001oxq.3	-	3	1085	c.842C>A	c.(841-843)ACA>AAA	p.T281K	LRRC32_uc001oxr.3_Missense_Mutation_p.T281K|LRRC32_uc010rsf.1_Missense_Mutation_p.T281K	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	281	LRR 10.|Extracellular (Potential).					integral to plasma membrane					0						GGGTGGCCCTGTGGGGAGCCG	0.657			NA											27	25					4.72057e-08	6.14029e-08	0.003954	1	0
ME3	10873	broad.mit.edu	37	11	86209034	86209034	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:86209034C>T	uc001pbz.2	-	5	930	c.676G>A	c.(676-678)GTG>ATG	p.V226M	ME3_uc001pca.2_Missense_Mutation_p.V226M|ME3_uc009yvk.2_Missense_Mutation_p.V226M|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	226					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	TCCAGCAGCACAGGGAGGCAC	0.647			NA											60	48					0	0	0.00361	0	0
ZBTB16	7704	broad.mit.edu	37	11	113935030	113935030	+	Silent	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:113935030G>C	uc001pop.2	+	2	1272	c.1008G>C	c.(1006-1008)GTG>GTC	p.V336V	ZBTB16_uc001poo.1_Silent_p.V336V|ZBTB16_uc001poq.2_Silent_p.V336V	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	336					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		TCTACTCCGTGTTGCCCAACC	0.652			NA											34	35					0	0	0.002836	0	0
FAM55A	120400	broad.mit.edu	37	11	114393211	114393211	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:114393211C>G	uc001ppa.2	-	6	1114	c.697G>C	c.(697-699)GAT>CAT	p.D233H	FAM55A_uc010rxd.1_Missense_Mutation_p.D82H	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	375						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		TCATGAAGATCAAAAAACTTC	0.303			NA											23	9					0	0	0.001882	0	0
MCAM	4162	broad.mit.edu	37	11	119181596	119181596	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:119181596G>A	uc001pwf.2	-	14	1692	c.1663C>T	c.(1663-1665)CCG>TCG	p.P555S	MCAM_uc001pwg.1_RNA	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	555	Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CGGCTCTCCGGCTCCGGCAGC	0.622			NA											14	112					0	0	0.004007	0	0
MCAM	4162	broad.mit.edu	37	11	119185575	119185575	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:119185575G>T	uc001pwf.2	-	3	397	c.368C>A	c.(367-369)TCC>TAC	p.S123Y		NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	123	Extracellular (Potential).|Ig-like V-type 1.				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		GTACTCCTGGGACCGAGGGCG	0.642			NA											34	37					4.31634e-10	6.02199e-10	0.002445	1	0
OR8D2	283160	broad.mit.edu	37	11	124189266	124189266	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:124189266C>T	uc010sah.1	-	1	828	c.828G>A	c.(826-828)GTG>GTA	p.V276V		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TGATGTAGAACACAGAAGACA	0.433			NA											18	101					0	0	0.006122	0	0
NTM	50863	broad.mit.edu	37	11	132016251	132016251	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr11:132016251G>A	uc001qgp.2	+	2	907	c.243G>A	c.(241-243)AAG>AAA	p.K81K	NTM_uc001qgm.2_Silent_p.K81K|NTM_uc010sch.1_Silent_p.K72K|NTM_uc010sci.1_Silent_p.K81K|NTM_uc010scj.1_Silent_p.K40K|NTM_uc001qgo.2_Silent_p.K81K|NTM_uc001qgq.2_Silent_p.K81K	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	81	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GGAATGACAAGTGGTGCCTGG	0.567			NA											42	39					0	0	0.00874	0	0
IQSEC3	440073	broad.mit.edu	37	12	283807	283807	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:283807G>T	uc001qhw.1	+	11	2254	c.2248G>T	c.(2248-2250)GGG>TGG	p.G750W		NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1053					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GCACAACTCCGGGCTGGGGGC	0.617			NA											14	12					4.14922e-12	6.03206e-12	0.004007	1	0
NOP2	4839	broad.mit.edu	37	12	6672656	6672656	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:6672656C>T	uc001qph.1	-	8	881	c.701G>A	c.(700-702)CGA>CAA	p.R234Q	NOP2_uc009zeq.1_5'UTR|NOP2_uc001qpi.1_Missense_Mutation_p.R234Q|NOP2_uc001qpj.1_Intron	NM_001033714	NP_001028886	P46087	NOP2_HUMAN	nucleolar protein 1, 120kDa	238					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						CTTGTGAACTCGTTGCAGGTC	0.547			NA									OREG0021630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	17					0	0	0.009096	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374735	8374735	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:8374735C>T	uc001qui.2	-	7	1637	c.1078G>A	c.(1078-1080)GAC>AAC	p.D360N	FAM90A1_uc001quh.2_Missense_Mutation_p.D360N	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	360							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		GGCTGCCGGTCGCCGCTAAGC	0.677			NA											5	57					0	0	0.001168	0	0
IPO8	10526	broad.mit.edu	37	12	30792602	30792602	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:30792602C>A	uc001rjd.2	-	21	2506	c.2336G>T	c.(2335-2337)CGT>CTT	p.R779L	IPO8_uc001rje.1_Missense_Mutation_p.R268L|IPO8_uc010sjt.1_Missense_Mutation_p.R574L	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	779					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					ACACATAGTACGAAGCTCACT	0.433			NA											7	54					5.18039e-06	6.28918e-06	0.00308	1	0
GLIPR1L1	256710	broad.mit.edu	37	12	75763886	75763886	+	Missense_Mutation	SNP	C	C	T	rs144682920		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:75763886C>T	uc001sxo.2	+	6	705	c.659C>T	c.(658-660)ACG>ATG	p.T220M	CAPS2_uc001sxm.3_Intron|CAPS2_uc009zsa.2_Intron|GLIPR1L1_uc001sxn.2_Missense_Mutation_p.T211M	NM_152779	NP_689992	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	220						extracellular region					0						CTGAAGCCAACGGGGAGAGCA	0.318			NA											4	33					0	0	0.000602	0	0
NAV3	89795	broad.mit.edu	37	12	78562599	78562599	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:78562599A>G	uc001syp.2	+	24	5107	c.4934A>G	c.(4933-4935)CAG>CGG	p.Q1645R	NAV3_uc001syo.2_Missense_Mutation_p.Q1645R|NAV3_uc010sub.1_Missense_Mutation_p.Q1131R|NAV3_uc009zsf.2_Missense_Mutation_p.Q476R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1645	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCTGCTGCCCAGGCGGCTATT	0.398			NA								HNSCC(70;0.22)			36	55					0	0	0.007835	0	0
RASSF9	9182	broad.mit.edu	37	12	86199250	86199250	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:86199250G>C	uc001taf.1	-	2	877	c.538C>G	c.(538-540)CGA>GGA	p.R180G		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	180					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						ATATTATCTCGATCATGAGAA	0.363			NA											46	84					0	0	0.00361	0	0
WSCD2	9671	broad.mit.edu	37	12	108589931	108589931	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:108589931G>T	uc001tms.2	+	2	1066	c.322G>T	c.(322-324)GGT>TGT	p.G108C	WSCD2_uc001tmt.2_Missense_Mutation_p.G108C	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	108						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						TGGCGACTACGGTGGAGCCTG	0.607			NA											15	59					2.61681e-11	3.726e-11	0.00245	1	0
WSCD2	9671	broad.mit.edu	37	12	108604067	108604067	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:108604067G>T	uc001tms.2	+	4	1411	c.667G>T	c.(667-669)GAG>TAG	p.E223*	WSCD2_uc001tmt.2_Nonsense_Mutation_p.E223*	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	223						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GCTGGCCCAGGAGTCGGCCCG	0.677			NA											4	6					0.00024832	0.000278054	0.009096	1	0
WSCD2	9671	broad.mit.edu	37	12	108634285	108634285	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:108634285A>G	uc001tms.2	+	8	2053	c.1309A>G	c.(1309-1311)ATA>GTA	p.I437V	WSCD2_uc001tmt.2_Missense_Mutation_p.I437V|WSCD2_uc001tmu.2_Missense_Mutation_p.I185V	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	437						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						CGGCGGCCACATAGGCTTTGC	0.542			NA											17	73					0	0	0.006122	0	0
TRPV4	59341	broad.mit.edu	37	12	110222182	110222182	+	Silent	SNP	C	C	A	rs141301107		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:110222182C>A	uc001tpj.1	-	14	2492	c.2397G>T	c.(2395-2397)CCG>CCT	p.P799P	TRPV4_uc001tpg.1_Silent_p.P765P|TRPV4_uc001tph.1_Silent_p.P752P|TRPV4_uc001tpi.1_Silent_p.P692P|TRPV4_uc001tpk.1_Silent_p.P799P|TRPV4_uc001tpl.1_Silent_p.P739P	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	799	Cytoplasmic (Potential).		P -> R (in MTD).|P -> S (in MTD).|P -> L (in MTD; also found in a patient with spondyloepiphyseal dysplasia Maroteaux type).|P -> A (in MTD).		actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CATTCTTGCCCGGGTCCTCGT	0.627			NA											39	81					9.62906e-15	1.48074e-14	0.00623	1	0
HVCN1	84329	broad.mit.edu	37	12	111099086	111099086	+	Silent	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:111099086T>C	uc001trs.1	-	4	354	c.189A>G	c.(187-189)TCA>TCG	p.S63S	HVCN1_uc001trq.1_Silent_p.S63S|HVCN1_uc001trt.1_Silent_p.S63S|HVCN1_uc010syd.1_Silent_p.S43S	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	63	Cytoplasmic (Potential).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						CTTCCTCGCCTGAGACTGGTG	0.517			NA											3	60					0	0	0.004672	0	0
MED13L	23389	broad.mit.edu	37	12	116452946	116452947	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:116452946_116452947CC>AG	uc001tvw.2	-	8	1197_1198	c.1142_1143GG>CT	c.(1141-1143)TGG>TCT	p.W381S		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	381					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TGCATTCCTTCCAGACTCGATG	0.441			NA											8	61					0	0	0.004672	0	0
FLT1	2321	broad.mit.edu	37	13	29008234	29008234	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr13:29008234C>A	uc001usb.3	-	5	922	c.637G>T	c.(637-639)GGG>TGG	p.G213W	FLT1_uc010aar.1_Missense_Mutation_p.G213W|FLT1_uc001usc.3_Missense_Mutation_p.G213W|FLT1_uc010tdp.1_Missense_Mutation_p.G213W	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	213	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TACAAATGCCCATTGACTGTT	0.393			NA											16	20					4.7546e-09	6.37633e-09	0.004007	1	0
TRPC4	7223	broad.mit.edu	37	13	38237769	38237769	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr13:38237769C>T	uc001uws.2	-	6	1707	c.1472G>A	c.(1471-1473)CGT>CAT	p.R491H	TRPC4_uc010abv.2_Missense_Mutation_p.R71H|TRPC4_uc001uwt.2_Missense_Mutation_p.R491H|TRPC4_uc010tey.1_Missense_Mutation_p.R491H|TRPC4_uc010abw.2_Missense_Mutation_p.R318H|TRPC4_uc010abx.2_Missense_Mutation_p.R491H|TRPC4_uc010aby.2_Missense_Mutation_p.R491H	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	491	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TGAGATCAGACGCAGAGAACT	0.448			NA											7	13					0	0	0.001984	0	0
SLITRK5	26050	broad.mit.edu	37	13	88327901	88327901	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr13:88327901C>T	uc001vln.2	+	2	477	c.258C>T	c.(256-258)CTC>CTT	p.L86L	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	86	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TCTACCACCTCTTGTTGTCCG	0.458			NA											32	79					0	0	0.009535	0	0
PABPN1	8106	broad.mit.edu	37	14	23792633	23792633	+	Silent	SNP	C	C	G	rs150035782		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr14:23792633C>G	uc001wjk.2	+	4	1864	c.582C>G	c.(580-582)GGC>GGG	p.G194G	PABPN1_uc001wjh.3_Silent_p.G221G|PABPN1_uc001wjj.2_Silent_p.G194G	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	194	Necessary for homooligomerization.|RRM.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ACTTTCATGGCTGTGGTTCAG	0.433			NA											10	86					0	0	0.001855	0	0
NOVA1	4857	broad.mit.edu	37	14	26917552	26917552	+	Silent	SNP	C	C	A	rs144344947		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr14:26917552C>A	uc001wpy.2	-	5	1455	c.1137G>T	c.(1135-1137)ACG>ACT	p.T379T	NOVA1_uc001wpz.2_Silent_p.T355T|NOVA1_uc001wqa.2_Silent_p.T257T	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	382	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		ATGTCCCCGCCGTACCACCAG	0.433			NA											11	30					0.00136819	0.00148866	0.001368	1	0
NOVA1	4857	broad.mit.edu	37	14	26917570	26917570	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr14:26917570G>A	uc001wpy.2	-	5	1437	c.1119C>T	c.(1117-1119)GGC>GGT	p.G373G	NOVA1_uc001wpz.2_Silent_p.G349G|NOVA1_uc001wqa.2_Silent_p.G251G	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	376	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CAGCTGTGCTGCCACTGGCTG	0.388			NA											7	27					0	0	0.00308	0	0
ASB2	51676	broad.mit.edu	37	14	94413696	94413696	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr14:94413696T>C	uc001ycc.1	-	5	1396	c.907A>G	c.(907-909)AGG>GGG	p.R303G	ASB2_uc001ycd.2_Missense_Mutation_p.R351G|ASB2_uc001yce.1_Missense_Mutation_p.R249G	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	303	ANK 8.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		TGGGCTGACCTGTAGTTGCCC	0.642			NA											20	51					0	0	0.002299	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103601623	103601623	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr14:103601623C>T	uc001ymm.1	+	11	2022	c.1891C>T	c.(1891-1893)CGG>TGG	p.R631W	TNFAIP2_uc010awo.1_Missense_Mutation_p.R291W|TNFAIP2_uc010txz.1_Missense_Mutation_p.R300W|TNFAIP2_uc010tya.1_Missense_Mutation_p.R114W	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	631					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)	Epithelial(46;0.191)			CAAGCGCATCCGGAGCATCTT	0.582			NA											20	286					0	0	0.008871	0	0
Unknown	0	broad.mit.edu	37	15	22440691	22440691	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:22440691G>C	uc001yug.2	-	1	175	c.156C>G	c.(154-156)AAC>AAG	p.N52K						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).												NA						AGTATTTCTTGTTACCTCCCC	0.532			NA											3	16					0	0	0.004672	0	0
C15orf2	23742	broad.mit.edu	37	15	24923001	24923001	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:24923001A>T	uc001ywo.2	+	1	2461	c.1987A>T	c.(1987-1989)AGT>TGT	p.S663C		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	663					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTCTCTCCCCAGTGCCTGTGT	0.507			NA											18	91					0	0	0.001882	0	0
GABRG3	2567	broad.mit.edu	37	15	27573971	27573971	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:27573971G>C	uc001zbg.1	+	5	676	c.510G>C	c.(508-510)GAG>GAC	p.E170D	GABRG3_uc001zbf.2_Missense_Mutation_p.E170D	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	170	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TCAATGCTGAGTGCCAGCTGC	0.597	NSCLC(114;800 1656 7410 37729 45293)		NA											8	30					0	0	0.00308	0	0
MTMR15	22909	broad.mit.edu	37	15	31197996	31197997	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:31197996_31197997GG>TT	uc001zff.2	+	2	1421_1422	c.1130_1131GG>TT	c.(1129-1131)CGG>CTT	p.R377L	MTMR15_uc001zfc.3_Missense_Mutation_p.R377L|MTMR15_uc010azw.2_Missense_Mutation_p.R377L|MTMR15_uc001zfd.3_Missense_Mutation_p.R377L|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	377					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		TACTACCTTCGGAGTTTCCTTG	0.426			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					23	90					0	0	0.004672	0	0
RYR3	6263	broad.mit.edu	37	15	34016317	34016317	+	Silent	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:34016317A>T	uc001zhi.2	+	45	6922	c.6852A>T	c.(6850-6852)GCA>GCT	p.A2284A	RYR3_uc010bar.2_Silent_p.A2284A	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2284	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGGCAATGCAATTATGTCAT	0.498			NA											10	11					0	0	0.008291	0	0
LPCAT4	254531	broad.mit.edu	37	15	34651440	34651440	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:34651440C>A	uc001zig.2	-	14	1557	c.1463G>T	c.(1462-1464)CGC>CTC	p.R488L		NM_153613	NP_705841	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	488					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding				0						GTGTGGGGGGCGCAGGTAGGT	0.552			NA											2	3					0.0016	0.00173542	0.004672	1	0
TCF12	6938	broad.mit.edu	37	15	57524917	57524917	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:57524917C>T	uc002aec.2	+	11	1117	c.833C>T	c.(832-834)CCT>CTT	p.P278L	TCF12_uc010ugm.1_Missense_Mutation_p.P330L|TCF12_uc010ugn.1_Missense_Mutation_p.P274L|TCF12_uc002aea.2_Missense_Mutation_p.P278L|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Missense_Mutation_p.P278L|TCF12_uc002aed.2_Missense_Mutation_p.P278L|TCF12_uc002aee.2_Missense_Mutation_p.P108L|TCF12_uc010bft.2_Missense_Mutation_p.P108L|TCF12_uc010ugo.1_Missense_Mutation_p.P42L	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	278					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		TAGAGTTATCCTCCACACTCA	0.383			NA	T	TEC	extraskeletal myxoid chondrosarcoma								4	23					0	0	0.009096	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65219162	65219162	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:65219162C>T	uc002aoa.2	+	6	563	c.534C>T	c.(532-534)CTC>CTT	p.L178L	ANKDD1A_uc002anx.1_Silent_p.L174L|ANKDD1A_uc002any.2_Silent_p.L87L|ANKDD1A_uc002anz.2_Silent_p.L87L|ANKDD1A_uc002aob.2_Intron|ANKDD1A_uc002aoc.2_RNA|ANKDD1A_uc010bha.2_Silent_p.L87L	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	178	ANK 5.				signal transduction					ovary(1)	1						TGGACTTCCTCGTGGGCTCTG	0.612			NA											11	45					0	0	0.001368	0	0
KIAA1024	23251	broad.mit.edu	37	15	79760677	79760677	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:79760677G>T	uc002bew.1	+	4	2777	c.2702G>T	c.(2701-2703)TGC>TTC	p.C901F	KIAA1024_uc010unk.1_3'UTR	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	901	Helical; (Potential).					integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						GCTGCGGCATGCACCGTCATC	0.458			NA											4	19					0.00909568	0.00962418	0.009096	1	0
ZNF598	90850	broad.mit.edu	37	16	2050050	2050050	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:2050050G>A	uc002cof.1	-	11	1515	c.1500C>T	c.(1498-1500)CCC>CCT	p.P500P	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	500						intracellular	zinc ion binding			lung(1)|breast(1)	2						CAAGGCTGGTGGGGGCGGTGC	0.682			NA											5	16					0	0	0.001168	0	0
MYLK3	91807	broad.mit.edu	37	16	46766575	46766575	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:46766575G>T	uc002eei.3	-	4	1123	c.1007C>A	c.(1006-1008)TCC>TAC	p.S336Y	MYLK3_uc010vge.1_5'UTR|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	336					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TATGTGGATGGAGATCCTGGG	0.343			NA											6	10					3.59834e-05	4.16396e-05	0.001168	1	0
NFATC3	4775	broad.mit.edu	37	16	68156767	68156767	+	Silent	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:68156767A>T	uc002evo.1	+	2	1191	c.981A>T	c.(979-981)CCA>CCT	p.P327P	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Silent_p.P327P|NFATC3_uc002evm.1_Silent_p.P327P|NFATC3_uc002evn.1_Silent_p.P327P|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	327					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CAGTTTTTCCATTTCAGTACT	0.483			NA											19	94					0	0	0.006122	0	0
HYDIN	54768	broad.mit.edu	37	16	70913523	70913523	+	Missense_Mutation	SNP	A	A	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:70913523A>C	uc002ezr.2	-	61	10477	c.10349T>G	c.(10348-10350)TTG>TGG	p.L3450W		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3451										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CAAGCCATCCAAGGTAGCCTC	0.577			NA											6	51					0	0	0.001984	0	0
PLCG2	5336	broad.mit.edu	37	16	81965179	81965179	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:81965179G>T	uc002fgt.2	+	25	2811	c.2659G>T	c.(2659-2661)GAG>TAG	p.E887*		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	887					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TCCTCCGGTGGAGTTTGCCAC	0.532			NA											16	59					2.32078e-09	3.16138e-09	0.003163	1	0
OSGIN1	29948	broad.mit.edu	37	16	83999018	83999018	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:83999018G>T	uc002fha.2	+	7	1472	c.1089G>T	c.(1087-1089)GCG>GCT	p.A363A	OSGIN1_uc002fhb.2_Silent_p.A280A|OSGIN1_uc002fhc.2_Silent_p.A280A	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	363					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						GGGTGGGTGCGGTGACCCCGG	0.697			NA											8	47					7.48243e-07	9.34628e-07	0.006214	1	0
ZCCHC14	23174	broad.mit.edu	37	16	87525384	87525384	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:87525384C>A	uc002fjz.1	-	1	77	c.50G>T	c.(49-51)CGC>CTC	p.R17L	ZCCHC14_uc002fka.1_RNA|uc002fkc.1_5'Flank	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	17					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GAGCTCCTGGCGCAGCACCTG	0.478			NA											6	25					3.59834e-05	4.16396e-05	0.001168	1	0
BANP	54971	broad.mit.edu	37	16	88061220	88061220	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr16:88061220C>T	uc002fkr.2	+	8	1224	c.1000C>T	c.(1000-1002)CGG>TGG	p.R334W	BANP_uc002fkp.2_Missense_Mutation_p.R304W|BANP_uc002fkq.2_Missense_Mutation_p.R304W|BANP_uc010vow.1_Missense_Mutation_p.R342W|BANP_uc002fks.3_Missense_Mutation_p.R303W|BANP_uc002fko.1_Missense_Mutation_p.R240W|BANP_uc010vov.1_Missense_Mutation_p.R309W	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	335	Necessary and sufficient for TP53 activation (By similarity).|Interaction with CUX1 and HDAC1 (By similarity).				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		GAGCTTCTCGCGGAGAACGCC	0.682			NA											13	54					0	0	0.001368	0	0
KDM6B	23135	broad.mit.edu	37	17	7754426	7754426	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:7754426A>G	uc002giw.1	+	14	4137	c.3761A>G	c.(3760-3762)GAT>GGT	p.D1254G	KDM6B_uc002gix.2_Missense_Mutation_p.D556G	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1254					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CAGCCCTCAGATGAGAACTGG	0.602			NA											8	48					0	0	0.00308	0	0
WDR16	146845	broad.mit.edu	37	17	9489141	9489141	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:9489141A>T	uc002gly.2	+	2	191	c.122A>T	c.(121-123)TAT>TTT	p.Y41F	WDR16_uc002glz.2_Intron|WDR16_uc010coc.2_Missense_Mutation_p.Y51F	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	41						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CATATGATTTATCCTCTTGGT	0.463			NA											22	83					0	0	0.001882	0	0
WDR16	146845	broad.mit.edu	37	17	9489143	9489143	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:9489143C>T	uc002gly.2	+	2	193	c.124C>T	c.(124-126)CCT>TCT	p.P42S	WDR16_uc002glz.2_Intron|WDR16_uc010coc.2_Missense_Mutation_p.P52S	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	42						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TATGATTTATCCTCTTGGTTG	0.463			NA											21	82					0	0	0.010504	0	0
MYH13	8735	broad.mit.edu	37	17	10265755	10265755	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:10265755G>A	uc002gmk.1	-	4	360	c.270C>T	c.(268-270)GAC>GAT	p.D90D		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	90	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCATGGCCATGTCCTCGATCT	0.468			NA											34	104					0	0	0.003271	0	0
MYH4	4622	broad.mit.edu	37	17	10346844	10346844	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:10346844C>A	uc002gmn.2	-	40	5779	c.5668G>T	c.(5668-5670)GAG>TAG	p.E1890*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1890	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GATTGTTCCTCCTGAGAACAG	0.443			NA											12	43					9.05144e-12	1.2995e-11	0.001855	1	0
VTN	7448	broad.mit.edu	37	17	26695911	26695911	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:26695911G>T	uc002hbc.2	-	5	957	c.808C>A	c.(808-810)CGG>AGG	p.R270R	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	270	Hemopexin-like 3.				cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	AAGTAGACCCGCTCCCGGCCA	0.587			NA											56	62					4.46115e-38	7.52955e-38	0.00361	1	0
SSH2	85464	broad.mit.edu	37	17	27958980	27958980	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:27958980T>A	uc002heo.1	-	15	3151	c.3151A>T	c.(3151-3153)ACT>TCT	p.T1051S	SSH2_uc010wbh.1_Missense_Mutation_p.T1078S	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1051					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CAGAGCACAGTGACAGATTTT	0.517			NA											53	48					0	0	0.00361	0	0
UTP6	55813	broad.mit.edu	37	17	30202318	30202318	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:30202318T>C	uc002hgr.2	-	14	1323	c.1240A>G	c.(1240-1242)ATC>GTC	p.I414V	UTP6_uc002hgq.2_Missense_Mutation_p.I230V|UTP6_uc010cst.2_Missense_Mutation_p.I263V	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	hepatocellular carcinoma-associated antigen 66	414					rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				TTTGACTCGATCAGCACCTGC	0.463			NA											35	65					0	0	0.004289	0	0
TMEM98	26022	broad.mit.edu	37	17	31258565	31258565	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:31258565G>T	uc002hhq.2	+	3	477	c.19G>T	c.(19-21)GTT>TTT	p.V7F	TMEM98_uc002hhr.2_Missense_Mutation_p.V7F	NM_015544	NP_056359	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	7	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			TGTGGTGATTGTTGCCATAGG	0.572			NA											6	5					1.58986e-06	1.95763e-06	0.008291	1	0
TMEM98	26022	broad.mit.edu	37	17	31258574	31258575	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:31258574_31258575GG>TT	uc002hhq.2	+	3	486_487	c.28_29GG>TT	c.(28-30)GGT>TTT	p.G10F	TMEM98_uc002hhr.2_Missense_Mutation_p.G10F	NM_015544	NP_056359	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	10	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			TGTTGCCATAGGTGTGCTGGCC	0.564			NA											7	7					0	0	0.004672	0	0
C17orf37	84299	broad.mit.edu	37	17	37886456	37886456	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:37886456C>T	uc002hsq.2	-	2	218	c.178G>A	c.(178-180)GGG>AGG	p.G60R		NM_032339	NP_115715	Q9BRT3	CQ037_HUMAN	hypothetical protein LOC84299	60					cell redox homeostasis	cytosol|membrane	selenium binding				0	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;3.72e-63)|all cancers(3;1.87e-56)|BRCA - Breast invasive adenocarcinoma(8;6.8e-45)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCTGTGCCCCCGAGGCGCGAC	0.582			NA											4	20					0	0	0.000602	0	0
STAT5B	6777	broad.mit.edu	37	17	40384145	40384145	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:40384145T>C	uc002hzh.2	-	2	170	c.1A>G	c.(1-3)ATG>GTG	p.M1V	STAT5B_uc002hzi.3_Missense_Mutation_p.M1V	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	1					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	CACACAGCCATGGTTTACAAT	0.423			NA											10	38					0	0	0.008291	0	0
SLC4A1	6521	broad.mit.edu	37	17	42336641	42336641	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:42336641C>A	uc002igf.3	-	9	915	c.766G>T	c.(766-768)GTG>TTG	p.V256L	SLC4A1_uc002igg.3_Missense_Mutation_p.V256L	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	256	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GGCAGCTCCACCGCCTCCAGC	0.652			NA											16	29					0.000422831	0.000470417	0.004007	1	0
SAMD14	201191	broad.mit.edu	37	17	48190269	48190269	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:48190269G>T	uc002iqg.2	-	10	1541	c.1242C>A	c.(1240-1242)GCC>GCA	p.A414A	SAMD14_uc002iqd.2_Silent_p.A197A|SAMD14_uc002iqe.2_Silent_p.A197A|SAMD14_uc002iqf.2_Silent_p.A442A	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	414	Potential.										0						AGCTCTTCTTGGCCTCCTGCT	0.701			NA											21	48					1.96292e-10	2.74968e-10	0.010504	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48917105	48917105	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:48917105C>A	uc002isv.3	+	2	1150	c.456C>A	c.(454-456)ACC>ACA	p.T152T	WFIKKN2_uc010dbu.2_Silent_p.T59T	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	152	Kazal-like.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			ACGGCCTCACCTACTATAACC	0.592			NA											24	41					5.35356e-11	7.5298e-11	0.00278	1	0
BPTF	2186	broad.mit.edu	37	17	65944403	65944403	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:65944403A>T	uc002jgf.2	+	23	7968	c.7907A>T	c.(7906-7908)GAT>GTT	p.D2636V	BPTF_uc002jge.2_Missense_Mutation_p.D2619V|BPTF_uc002jgg.2_Missense_Mutation_p.D293V|BPTF_uc002jgh.2_Missense_Mutation_p.D95V	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2762					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CTGGACAAGGATCTGCAAATT	0.463			NA											10	28					0	0	0.000978	0	0
RNF157	114804	broad.mit.edu	37	17	74163145	74163145	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:74163145T>A	uc002jqz.2	-	5	575	c.506A>T	c.(505-507)CAG>CTG	p.Q169L	RNF157_uc002jra.2_Missense_Mutation_p.Q169L	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	169							zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			GCAGAACTGCTGACACACTCC	0.562	GBM(186;507 2120 27388 27773 52994)		NA											14	117					0	0	0.00245	0	0
USP36	57602	broad.mit.edu	37	17	76831489	76831489	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:76831489C>A	uc002jvz.1	-	4	673	c.348G>T	c.(346-348)CGG>CGT	p.R116R	USP36_uc002jwa.1_Silent_p.R116R|USP36_uc002jwd.1_Silent_p.R116R	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	116					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CGCGGAAGACCCGCTCCCACC	0.597			NA											11	34					3.86212e-05	4.41021e-05	0.008291	1	0
CBX2	84733	broad.mit.edu	37	17	77757821	77757821	+	Silent	SNP	G	G	T	rs144185230		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:77757821G>T	uc002jxc.2	+	5	621	c.579G>T	c.(577-579)CTG>CTT	p.L193L		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	193					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGAAGGATCTGGGGGCCCCGG	0.697			NA											25	40					3.28513e-13	4.89937e-13	0.003954	1	0
LAMA1	284217	broad.mit.edu	37	18	6978269	6978269	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:6978269G>C	uc002knm.2	-	43	6210	c.6116C>G	c.(6115-6117)ACA>AGA	p.T2039R	LAMA1_uc010wzj.1_Missense_Mutation_p.T1515R	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2039	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTGGCAGATGTGTTCAGCAG	0.607			NA											22	110					0	0	0.001882	0	0
LRRC30	339291	broad.mit.edu	37	18	7231236	7231236	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:7231236C>G	uc010wzk.1	+	1	100	c.100C>G	c.(100-102)CTG>GTG	p.L34V		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	34										ovary(1)|liver(1)	2						GGACGATGCCCTGCTCTCGGG	0.612			NA											29	90					0	0	0.00632	0	0
RAB31	11031	broad.mit.edu	37	18	9792205	9792205	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:9792205C>A	uc002kog.2	+	3	349	c.174C>A	c.(172-174)CTC>CTA	p.L58L		NM_006868	NP_006859	Q13636	RAB31_HUMAN	RAB31, member RAS oncogene family	57					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						ACAAGTTCCTCATCTGGGACA	0.398			NA											9	16					5.16669e-11	7.32653e-11	0.000978	1	0
MC5R	4161	broad.mit.edu	37	18	13825772	13825772	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:13825772C>A	uc010xaf.1	+	1	8	c.8C>A	c.(7-9)TCC>TAC	p.S3Y		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	3	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						GCAATGAATTCCTCATTTCAC	0.408			NA											18	61					1.67942e-08	2.23491e-08	0.006122	1	0
POTEC	388468	broad.mit.edu	37	18	14542825	14542825	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:14542825G>A	uc010dln.2	-	1	775	c.321C>T	c.(319-321)CCC>CCT	p.P107P	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	107										skin(3)	3						CCCTGCAGCAGGGGAAGCAGT	0.607			NA											12	343					0	0	0.004007	0	0
ZNF521	25925	broad.mit.edu	37	18	22806904	22806904	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:22806904G>T	uc002kvk.2	-	4	1225	c.978C>A	c.(976-978)TAC>TAA	p.Y326*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.Y326*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.Y106*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	326	C2H2-type 8.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CCATGTGGCTGTACAGTTCCT	0.537			NA	T	PAX5	ALL								11	53					4.68919e-08	6.12249e-08	0.008291	1	0
ACAA2	10449	broad.mit.edu	37	18	47317871	47317871	+	Silent	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:47317871T>A	uc002ldw.3	-	7	1249	c.852A>T	c.(850-852)GTA>GTT	p.V284V	ACAA2_uc002ldx.3_Silent_p.V281V	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2	284					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						CACATCCAGATACAAAGTAGC	0.398			NA											19	41					0	0	0.006122	0	0
SOCS6	9306	broad.mit.edu	37	18	67992499	67992499	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr18:67992499G>T	uc002lkr.1	+	2	911	c.595G>T	c.(595-597)GGA>TGA	p.G199*	SOCS6_uc010dqq.2_Nonsense_Mutation_p.G199*	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	199					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TTCTCATAATGGAGACCTGCA	0.507	Melanoma(84;1024 1361 24382 36583 42651)		NA											15	92					4.7546e-09	6.37633e-09	0.004007	1	0
STK11	6794	broad.mit.edu	37	19	1220486	1220487	+	Missense_Mutation	DNP	CG	CG	AT	rs121913315		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:1220486_1220487CG>AT	uc002lrl.1	+	4	1694_1695	c.579_580CG>AT	c.(577-582)TCCGAC>TCATAC	p.D194Y		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	194	Protein kinase.		D -> V (in lung cancer; somatic mutation).|D -> Y (in melanoma; sporadic malignant; somatic mutation).|D -> N (in PJS).	D->A: Loss of kinase activity.	anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.D194Y(6)|p.Y156fs*87(4)|p.?(3)|p.D194N(3)|p.D194fs*93(1)|p.D194V(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAAAATCTCCGACCTGGGCGT	0.673		D194N(ALEXANDERCELLS_LIVER)|D194N(PLCPRF5_LIVER)	14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			7	6					0	0	0.004672	0	0
MUM1	84939	broad.mit.edu	37	19	1360189	1360189	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:1360189C>T	uc010xgm.1	+	4	338	c.269C>T	c.(268-270)TCG>TTG	p.S90L	MUM1_uc010dsi.2_Missense_Mutation_p.S22L|MUM1_uc002lrz.2_Missense_Mutation_p.S91L|MUM1_uc002lsb.2_Missense_Mutation_p.S22L|MUM1_uc002lsc.1_Missense_Mutation_p.S22L			Q2TAK8	MUM1_HUMAN	SubName: Full=MUM1 protein;	90					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACAGACGGTCGCTTCGCGTG	0.587			NA									OREG0025088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	52					0	0	0.003163	0	0
FCER2	2208	broad.mit.edu	37	19	7764626	7764626	+	Silent	SNP	T	T	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:7764626T>G	uc002mhn.2	-	2	205	c.21A>C	c.(19-21)TCA>TCC	p.S7S	FCER2_uc010xjs.1_5'UTR|FCER2_uc010xjt.1_5'UTR|FCER2_uc002mhm.2_Silent_p.S7S|FCER2_uc010dvo.2_Silent_p.S7S	NM_002002	NP_001993	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor	7	Cytoplasmic (Potential).				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding				0						TCCTCCTACCTGAATATTGAC	0.408			NA											16	20					0	0	0.007413	0	0
CCL25	6370	broad.mit.edu	37	19	8121118	8121118	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:8121118G>A	uc002mjd.2	+	2	156	c.156G>A	c.(154-156)CAG>CAA	p.Q52Q	CCL25_uc002mjc.3_Silent_p.Q52Q|CCL25_uc010dvy.1_Silent_p.Q52Q	NM_005624	NP_005615	O15444	CCL25_HUMAN	small inducible cytokine A25 precursor	52					chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|hormone activity				0						ACCGGATCCAGGAGGTGAGCG	0.667			NA											30	18					0	0	0.002096	0	0
MUC16	94025	broad.mit.edu	37	19	9024194	9024194	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:9024194C>A	uc002mkp.2	-	18	37282	c.37078G>T	c.(37078-37080)GGG>TGG	p.G12360W		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12362	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGAGGTCCCAGGAGCTGAG	0.488			NA											10	15					2.80697e-09	3.80868e-09	0.000978	1	0
MAP4K1	11184	broad.mit.edu	37	19	39104688	39104688	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:39104688C>T	uc002oix.1	-	7	563	c.455G>A	c.(454-456)AGA>AAA	p.R152K	MAP4K1_uc002oiy.1_Missense_Mutation_p.R152K|MAP4K1_uc010xug.1_5'Flank	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	152	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCACCCAATCTGACCTCCCC	0.607			NA											5	101					0	0	0.000602	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915411	39915411	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:39915411C>G	uc010xuz.1	+	19	3963	c.3638C>G	c.(3637-3639)CCT>CGT	p.P1213R	PLEKHG2_uc010xuy.1_Missense_Mutation_p.P1154R|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.P991R	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1213					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCTGCCACACCTTTACCTGAG	0.537			NA											15	252					0	0	0.00499	0	0
CEACAM5	1048	broad.mit.edu	37	19	42219069	42219069	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:42219069C>A	uc002ork.2	+	3	725	c.604C>A	c.(604-606)CTA>ATA	p.L202I	CEACAM5_uc010ehz.1_Missense_Mutation_p.L202I|CEACAM5_uc002orj.1_Missense_Mutation_p.L202I|CEACAM5_uc002orl.2_Missense_Mutation_p.L202I	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	202	Ig-like 2.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GACCCTCACTCTATTCAATGT	0.522			NA											89	77					4.78148e-37	7.99224e-37	0.00361	1	0
CCDC155	147872	broad.mit.edu	37	19	49920437	49920437	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:49920437G>C	uc002pnm.1	+	19	1635	c.1461G>C	c.(1459-1461)CAG>CAC	p.Q487H	CCDC155_uc010emx.1_Missense_Mutation_p.Q458H	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	487						integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						GGGAACTCCAGCAAGCCCTGG	0.647			NA											14	8					0	0	0.00245	0	0
LILRA2	11027	broad.mit.edu	37	19	55086759	55086759	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:55086759G>T	uc002qgg.3	+	5	781	c.692G>T	c.(691-693)GGT>GTT	p.G231V	LILRA2_uc010ern.2_Missense_Mutation_p.G231V|LILRA2_uc002qgf.2_Missense_Mutation_p.G231V|LILRA2_uc010yfe.1_Missense_Mutation_p.G231V|LILRA2_uc010yff.1_Missense_Mutation_p.G219V|LILRA2_uc010ero.2_Missense_Mutation_p.G219V|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	231	Ig-like C2-type 3.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GTGCAGCCAGGTCCTATGGTG	0.557			NA											15	86					3.99206e-14	6.03167e-14	0.007413	1	0
LILRB1	10859	broad.mit.edu	37	19	55146111	55146111	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:55146111G>T	uc002qgj.2	+	11	1720	c.1380G>T	c.(1378-1380)GGG>GGT	p.G460G	LILRB1_uc010erp.1_Silent_p.G75G|LILRB1_uc002qgl.2_Silent_p.G460G|LILRB1_uc002qgk.2_Silent_p.G461G|LILRB1_uc002qgm.2_Silent_p.G461G|LILRB1_uc010erq.2_Silent_p.G444G|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	460	Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GGCACCTGGGGGTTGTGATCG	0.333			NA								HNSCC(37;0.09)			24	17					1.10513e-12	1.63409e-12	0.002299	1	0
NLRP4	147945	broad.mit.edu	37	19	56369436	56369436	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr19:56369436T>C	uc002qmd.3	+	3	1099	c.677T>C	c.(676-678)CTC>CCC	p.L226P	NLRP4_uc002qmf.2_Missense_Mutation_p.L151P|NLRP4_uc010etf.2_Missense_Mutation_p.L57P	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	226	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCGGAGAGACTCTTGTTCGTC	0.562			NA											24	71					0	0	0.00278	0	0
NBAS	51594	broad.mit.edu	37	2	15651350	15651350	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:15651350C>A	uc002rcc.1	-	10	897	c.871G>T	c.(871-873)GAC>TAC	p.D291Y	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	291										ovary(2)|liver(1)|skin(1)	4						GTAACCCCGTCTCCACCATTA	0.413			NA											32	137					1.62565e-12	2.38336e-12	0.002445	1	0
TMEM214	54867	broad.mit.edu	37	2	27260556	27260556	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:27260556G>C	uc002ria.3	+	9	1248	c.1138G>C	c.(1138-1140)GAG>CAG	p.E380Q	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.E335Q	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	380						integral to membrane	protein binding				0						CTGTCCCCCTGAGATGAAGAA	0.557			NA											19	58					0	0	0.010504	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37349800	37349801	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:37349800_37349801CC>AA	uc010ynh.1	-	12	1472_1473	c.915_916GG>TT	c.(913-918)GCGGAG>GCTTAG	p.E306*	EIF2AK2_uc010fab.1_Nonsense_Mutation_p.E265*|EIF2AK2_uc010yng.1_Nonsense_Mutation_p.E306*|EIF2AK2_uc010fac.2_Nonsense_Mutation_p.E306*|EIF2AK2_uc010fad.2_Intron	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	306	Protein kinase.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				ACTTCACGCTCCGCCTTCCTAG	0.411			NA											9	44					0	0	0.004672	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655869	40655869	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:40655869G>A	uc002rrx.2	-	1	1576	c.1552C>T	c.(1552-1554)CTT>TTT	p.L518F	SLC8A1_uc002rry.2_Missense_Mutation_p.L518F|SLC8A1_uc002rrz.2_Missense_Mutation_p.L518F|SLC8A1_uc002rsa.2_Missense_Mutation_p.L518F|SLC8A1_uc002rsd.3_Missense_Mutation_p.L518F|SLC8A1_uc002rsb.1_Missense_Mutation_p.L518F|SLC8A1_uc010fan.1_Missense_Mutation_p.L518F|SLC8A1_uc002rsc.1_Missense_Mutation_p.L518F	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	518	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AGGCAAGCAAGTGTAGAAACA	0.433			NA											12	37					0	0	0.000978	0	0
GFPT1	2673	broad.mit.edu	37	2	69575396	69575396	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:69575396G>A	uc002sfh.2	-	10	1041	c.862C>T	c.(862-864)CGT>TGT	p.R288C		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	306					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						ATAGAAAGACGTCCATCCACT	0.448			NA											20	60					0	0	0.007413	0	0
CTNNA2	1496	broad.mit.edu	37	2	80773180	80773180	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:80773180C>G	uc010ysh.1	+	10	1537	c.1532C>G	c.(1531-1533)TCT>TGT	p.S511C	CTNNA2_uc010yse.1_Missense_Mutation_p.S511C|CTNNA2_uc010ysf.1_Missense_Mutation_p.S511C|CTNNA2_uc010ysg.1_Missense_Mutation_p.S511C|CTNNA2_uc010ysi.1_Missense_Mutation_p.S143C	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	511					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GACTTCCTCTCTGTCTCAGGT	0.498			NA											5	12					0	0	0.000602	0	0
IWS1	55677	broad.mit.edu	37	2	128262314	128262314	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:128262314C>A	uc002ton.2	-	3	1468	c.1165G>T	c.(1165-1167)GTA>TTA	p.V389L	IWS1_uc010yzl.1_RNA|uc002too.1_5'Flank|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	389	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		CTCTTCGCTACTTTCTCCTCC	0.398			NA											66	114					3.12118e-38	5.29377e-38	0.00361	1	0
NCKAP5	344148	broad.mit.edu	37	2	133543054	133543054	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:133543054T>C	uc002ttp.2	-	14	1704	c.1330A>G	c.(1330-1332)AGC>GGC	p.S444G	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	444							protein binding				0						TTGAGGCTGCTACTTTTAATT	0.448			NA											8	38					0	0	0.00308	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135892886	135892886	+	Silent	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:135892886A>T	uc002tuj.2	+	16	1576	c.1551A>T	c.(1549-1551)CTA>CTT	p.L517L	RAB3GAP1_uc010fnf.2_Silent_p.L517L|RAB3GAP1_uc010fng.2_Silent_p.L342L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	517						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		ATCAGAAACTACAGGTAAAGA	0.333			NA											4	17					0	0	0.009096	0	0
LCT	3938	broad.mit.edu	37	2	136570242	136570242	+	Silent	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:136570242G>C	uc002tuu.1	-	7	2003	c.1992C>G	c.(1990-1992)CCC>CCG	p.P664P		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	664	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTGTGAACTCGGGGAGTTGAG	0.557			NA											30	58					0	0	0.002445	0	0
LRP1B	53353	broad.mit.edu	37	2	141457912	141457912	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:141457912T>C	uc002tvj.1	-	41	7678	c.6706A>G	c.(6706-6708)AAA>GAA	p.K2236E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2236	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGTACCTTTTCTTCTTTGA	0.343	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			14	72					0	0	0.001855	0	0
SLC4A10	57282	broad.mit.edu	37	2	162719564	162719564	+	Missense_Mutation	SNP	A	A	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:162719564A>C	uc002ubx.3	+	6	942	c.758A>C	c.(757-759)GAC>GCC	p.D253A	SLC4A10_uc010fpa.1_Missense_Mutation_p.D265A|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.D253A|SLC4A10_uc010zcs.1_Missense_Mutation_p.D264A	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	253	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						AATTCCATGGACAAAAATGGT	0.338			NA											5	35					0	0	0.001168	0	0
SCN3A	6328	broad.mit.edu	37	2	166003311	166003311	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:166003311A>T	uc002ucx.2	-	12	2101	c.1609T>A	c.(1609-1611)TTC>ATC	p.F537I	SCN3A_uc002ucy.2_Missense_Mutation_p.F537I|SCN3A_uc002ucz.2_Missense_Mutation_p.F537I|SCN3A_uc002uda.1_Missense_Mutation_p.F406I|SCN3A_uc002udb.1_Missense_Mutation_p.F406I	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	537						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GAGAAAAGGAAGCTGCTTCTT	0.428			NA											19	91					0	0	0.006122	0	0
SCN2A	6326	broad.mit.edu	37	2	166172258	166172258	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:166172258C>T	uc002udc.2	+	11	1951	c.1661C>T	c.(1660-1662)TCT>TTT	p.S554F	SCN2A_uc002udd.2_Missense_Mutation_p.S554F|SCN2A_uc002ude.2_Missense_Mutation_p.S554F	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	554					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGATTTTCTTCTCCACACCAG	0.348			NA											18	55					0	0	0.001882	0	0
GALNT3	2591	broad.mit.edu	37	2	166626801	166626801	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:166626801T>A	uc010fph.1	-	2	797	c.410A>T	c.(409-411)GAG>GTG	p.E137V	GALNT3_uc010fpi.1_Missense_Mutation_p.E137V|GALNT3_uc002udi.2_Missense_Mutation_p.E137V	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	137	Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						TTCCTTTTGCTCTTCAACACT	0.463			NA											14	66					0	0	0.001855	0	0
XIRP2	129446	broad.mit.edu	37	2	168101680	168101680	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:168101680T>A	uc002udx.2	+	8	3796	c.3778T>A	c.(3778-3780)TGT>AGT	p.C1260S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.C1085S|XIRP2_uc010fpq.2_Missense_Mutation_p.C1038S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1085					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGTGATGAATGTGTTAAGAC	0.338			NA											10	52					0	0	0.000978	0	0
XIRP2	129446	broad.mit.edu	37	2	168102400	168102400	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:168102400G>A	uc002udx.2	+	8	4516	c.4498G>A	c.(4498-4500)GAT>AAT	p.D1500N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D1325N|XIRP2_uc010fpq.2_Missense_Mutation_p.D1278N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1325	Xin 27.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCGAACTTTCGATTCTATTAT	0.388			NA											18	27					0	0	0.006122	0	0
MYO3B	140469	broad.mit.edu	37	2	171262076	171262076	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:171262076G>A	uc002ufy.2	+	21	2596	c.2453G>A	c.(2452-2454)CGA>CAA	p.R818Q	MYO3B_uc002ufv.2_Missense_Mutation_p.R805Q|MYO3B_uc010fqb.1_Missense_Mutation_p.R805Q|MYO3B_uc002ufz.2_Missense_Mutation_p.R818Q|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	818	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GATAATCTACGATGCAAATAC	0.388			NA											17	33					0	0	0.004007	0	0
TTN	7273	broad.mit.edu	37	2	179604234	179604234	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:179604234T>C	uc010zfh.1	-	46	13437	c.13213A>G	c.(13213-13215)AAA>GAA	p.K4405E	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.K4338E|TTN_uc010zfj.1_Missense_Mutation_p.K4213E|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	4332							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTCCTCTTTTTCCTCTGAT	0.448			NA											15	68					0	0	0.00499	0	0
SATB2	23314	broad.mit.edu	37	2	200193550	200193550	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:200193550C>A	uc002uuy.1	-	8	2074	c.1257G>T	c.(1255-1257)CAG>CAT	p.Q419H	SATB2_uc010fsq.1_Missense_Mutation_p.Q301H|SATB2_uc002uuz.1_Missense_Mutation_p.Q419H|SATB2_uc002uva.1_Missense_Mutation_p.Q419H	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	419	CUT 1.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGAGGAAATTCTGCATGGCCC	0.517	Colon(30;262 767 11040 24421 36230)		NA											8	34					1.12685e-05	1.35379e-05	0.004482	1	0
MAP2	4133	broad.mit.edu	37	2	210560620	210560620	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:210560620G>C	uc002vde.1	+	7	3974	c.3726G>C	c.(3724-3726)CAG>CAC	p.Q1242H	MAP2_uc002vdc.1_Missense_Mutation_p.Q1242H|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.Q1238H	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1242					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TAGAAGCCCAGGGAGAATATG	0.488	Pancreas(27;423 979 28787 29963)		NA											6	54					0	0	0.001168	0	0
CPS1	1373	broad.mit.edu	37	2	211504723	211504723	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:211504723C>A	uc002vee.3	+	24	3031	c.2899C>A	c.(2899-2901)CAT>AAT	p.H967N	CPS1_uc010fur.2_Missense_Mutation_p.H973N|CPS1_uc010fus.2_Missense_Mutation_p.H516N	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	967					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TCCTCAGGAGCATGATGTCAA	0.279			NA											7	40					1.76689e-08	2.34232e-08	0.006214	1	0
IGFBP5	3488	broad.mit.edu	37	2	217543575	217543575	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:217543575G>T	uc002vgj.3	-	2	1339	c.565C>A	c.(565-567)CAG>AAG	p.Q189K		NM_000599	NP_000590	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5	189	Thyroglobulin type-1.				negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding				0		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGATGCACCTGCTCAGACTCC	0.562			NA											9	17					2.17888e-05	2.56426e-05	0.006214	1	0
CCDC108	255101	broad.mit.edu	37	2	219892675	219892675	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:219892675G>T	uc002vjl.1	-	13	1992	c.1908C>A	c.(1906-1908)TTC>TTA	p.F636L	CCDC108_uc010fwa.1_Missense_Mutation_p.F79L|CCDC108_uc010zkp.1_Missense_Mutation_p.F625L|CCDC108_uc010zkq.1_Missense_Mutation_p.F571L	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	636						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGTCGAAGAAGAACTCGGTCA	0.607			NA											21	83					3.10358e-05	3.64013e-05	0.002299	1	0
CHPF	79586	broad.mit.edu	37	2	220408109	220408109	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:220408109G>A	uc002vmc.3	-	1	379	c.152C>T	c.(151-153)CCG>CTG	p.P51L	CHPF_uc010zlh.1_5'Flank|CHPF_uc002vmd.3_Missense_Mutation_p.P51L|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	51	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCCGCGCGGCGGCAGCTCAGA	0.741			NA											3	13					0	0	0.009096	0	0
NDUFA10	4705	broad.mit.edu	37	2	240944656	240944656	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:240944656G>C	uc002vyn.2	-	8	941	c.861C>G	c.(859-861)GAC>GAG	p.D287E	NDUFA10_uc010fzc.1_Missense_Mutation_p.D317E	NM_004544	NP_004535	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	287					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)	1		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AAGTGCGATTGTCCTGCTTGA	0.458			NA											20	92					0	0	0.001882	0	0
ZNF133	7692	broad.mit.edu	37	20	18296354	18296354	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:18296354A>G	uc010gcq.2	+	5	1164	c.859A>G	c.(859-861)ATA>GTA	p.I287V	ZNF133_uc010zrv.1_Missense_Mutation_p.I290V|ZNF133_uc010zrw.1_Missense_Mutation_p.I224V|ZNF133_uc010gcr.2_Missense_Mutation_p.I287V|ZNF133_uc010zrx.1_Missense_Mutation_p.I192V|ZNF133_uc002wql.3_Missense_Mutation_p.I286V|ZNF133_uc010gcs.2_Missense_Mutation_p.I286V|ZNF133_uc010zry.1_Missense_Mutation_p.I192V|ZNF133_uc002wqm.2_Missense_Mutation_p.I287V	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	287	C2H2-type 3.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						AACGCTAATCATACACGAACG	0.532			NA											10	55					0	0	0.006214	0	0
PLAGL2	5326	broad.mit.edu	37	20	30785287	30785287	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:30785287G>A	uc002wxn.2	-	3	676	c.459C>T	c.(457-459)AGC>AGT	p.S153S		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	153						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGAGGTCACCGCTGCTGGCAG	0.602	Colon(163;15 1893 11280 16306 47518)		NA											4	31					0	0	0.009096	0	0
KIAA1755	85449	broad.mit.edu	37	20	36874455	36874455	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:36874455G>T	uc002xhy.1	-	2	349	c.77C>A	c.(76-78)CCC>CAC	p.P26H	KIAA1755_uc002xhz.1_Missense_Mutation_p.P26H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	26										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CAGGACGGTGGGTGCTGTGGC	0.632			NA											14	27					6.31663e-08	8.12473e-08	0.003163	1	0
PTPRT	11122	broad.mit.edu	37	20	40877433	40877433	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:40877433C>T	uc002xkg.2	-	14	2390	c.2206G>A	c.(2206-2208)GAG>AAG	p.E736K	PTPRT_uc010ggj.2_Missense_Mutation_p.E755K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	736	Extracellular (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTCTCTGGCTCCACAGTGTTA	0.502			NA											10	34					0	0	0.006214	0	0
ZSWIM1	90204	broad.mit.edu	37	20	44511423	44511423	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:44511423G>T	uc010ghi.2	+	2	305	c.192G>T	c.(190-192)CAG>CAT	p.Q64H	ZSWIM1_uc010zxh.1_Intron	NM_080603	NP_542170	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	64							zinc ion binding			skin(1)	1		Myeloproliferative disorder(115;0.028)				TCAACTACCAGAGCTGCTTTA	0.473			NA											16	26					3.52763e-06	4.29775e-06	0.00499	1	0
SLC13A3	64849	broad.mit.edu	37	20	45195002	45195002	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:45195002C>A	uc002xsf.1	-	11	1398	c.1360G>T	c.(1360-1362)GGG>TGG	p.G454W	SLC13A3_uc010ghn.1_Missense_Mutation_p.G423W|SLC13A3_uc010zxw.1_Missense_Mutation_p.G404W|SLC13A3_uc002xsg.1_Missense_Mutation_p.G407W|SLC13A3_uc010gho.1_Missense_Mutation_p.G372W|SLC13A3_uc010zxx.1_Missense_Mutation_p.G356W|SLC13A3_uc002xse.1_5'Flank|SLC13A3_uc010ghm.1_Missense_Mutation_p.G41W|SLC13A3_uc010zxv.1_Missense_Mutation_p.G39W	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	454	Cytoplasmic (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	TGCAGCTGCCCACCAATCCAT	0.617			NA											25	97					3.01185e-09	4.0707e-09	0.003954	1	0
EYA2	2139	broad.mit.edu	37	20	45801492	45801492	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:45801492A>T	uc002xsm.2	+	12	1549	c.1175A>T	c.(1174-1176)AAT>ATT	p.N392I	EYA2_uc010ghp.2_Missense_Mutation_p.N392I|EYA2_uc002xsn.2_Missense_Mutation_p.N397I|EYA2_uc002xso.2_Missense_Mutation_p.N392I|EYA2_uc002xsp.2_Missense_Mutation_p.N392I|EYA2_uc002xsq.2_Missense_Mutation_p.N362I	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	392					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				GAGATGTACAATACCTACAAG	0.582	Pancreas(120;56 1725 18501 25218 43520)		NA											15	52					0	0	0.00245	0	0
SPO11	23626	broad.mit.edu	37	20	55906984	55906984	+	Nonsense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:55906984C>G	uc002xye.2	+	2	320	c.227C>G	c.(226-228)TCA>TGA	p.S76*	SPO11_uc002xyf.2_Intron	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	76					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			GACAACAGATCAAGCTGGGAA	0.313			NA						Editing_and_processing_nucleases					26	132					0	0	0.004656	0	0
COL9A3	1299	broad.mit.edu	37	20	61452879	61452879	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr20:61452879C>A	uc002ydm.2	+	7	369	c.366C>A	c.(364-366)CCC>CCA	p.P122P		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	122	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					TCCCTGGACCCCCCGTGAGTA	0.647			NA											9	43					0.00829132	0.00879999	0.008291	1	0
TPTE	7179	broad.mit.edu	37	21	10920121	10920121	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr21:10920121T>A	uc002yip.1	-	19	1501	c.1133A>T	c.(1132-1134)CAC>CTC	p.H378L	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.H360L|TPTE_uc002yir.1_Missense_Mutation_p.H340L|TPTE_uc010gkv.1_Missense_Mutation_p.H240L	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	378	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTTTCGCTGTGGGTTTTATC	0.383			NA											6	46					0	0	0.001168	0	0
LIPI	149998	broad.mit.edu	37	21	15538703	15538703	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr21:15538703C>G	uc002yjm.2	-	5	786	c.776G>C	c.(775-777)TGT>TCT	p.C259S	LIPI_uc010gkw.1_Intron	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	238					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TGATTTAGGACAGCCAGGTTG	0.348			NA											9	61					0	0	0.006214	0	0
HSPA13	6782	broad.mit.edu	37	21	15753847	15753847	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr21:15753847G>A	uc002yjt.2	-	2	112	c.43C>T	c.(43-45)CTC>TTC	p.L15F	HSPA13_uc011abx.1_5'UTR	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	15						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						GCCAACAGGAGAGTCAAAACA	0.373			NA											8	18					0	0	0.006214	0	0
TRPM2	7226	broad.mit.edu	37	21	45825814	45825814	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr21:45825814G>T	uc002zet.1	+	19	2897	c.2684G>T	c.(2683-2685)GGG>GTG	p.G895V	TRPM2_uc002zeu.1_Missense_Mutation_p.G895V|TRPM2_uc002zew.1_Missense_Mutation_p.G895V|TRPM2_uc010gpt.1_Missense_Mutation_p.G895V|TRPM2_uc002zex.1_Missense_Mutation_p.G681V|TRPM2_uc002zey.1_Missense_Mutation_p.G408V	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	895	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTGTACCCCGGGCGCGTCATC	0.617			NA											26	79					1.1804e-14	1.80716e-14	0.003954	1	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021441	46021441	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr21:46021441G>T	uc002zfn.3	+	2	930	c.905G>T	c.(904-906)TGC>TTC	p.C302F	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198689	NP_941962	P60409	KR107_HUMAN	keratin associated protein 10-7	307	27.|30 X 5 AA repeats of C-C-X(3).					keratin filament					0						ACCACCTCCTGCTGCAGACCC	0.672			NA											26	99					7.38237e-10	1.02172e-09	0.00632	1	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047942	46047942	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr21:46047942C>T	uc002zfp.3	+	1	903	c.854C>T	c.(853-855)TCC>TTC	p.S285F	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	285						keratin filament					0						TACAGCTTCTCCTCAGGCCAG	0.701			NA											23	63					0	0	0.007291	0	0
CACNA1I	8911	broad.mit.edu	37	22	39966877	39966877	+	Silent	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr22:39966877G>A	uc003ayc.2	+	1	120	c.120G>A	c.(118-120)GAG>GAA	p.E40E	CACNA1I_uc003ayd.2_Silent_p.E40E	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	40	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GCCTGGAGGAGCCTCTGGATG	0.677			NA											17	64					0	0	0.004007	0	0
GRM7	2917	broad.mit.edu	37	3	6903146	6903146	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:6903146T>A	uc003bqm.2	+	1	345	c.71T>A	c.(70-72)CTC>CAC	p.L24H	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.L24H|GRM7_uc003bql.2_Missense_Mutation_p.L24H	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	24					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CTGGAGGTGCTCCTGTGCGCG	0.706			NA											4	8					0	0	0.009096	0	0
ITGA9	3680	broad.mit.edu	37	3	37512507	37512507	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:37512507G>T	uc003chd.2	+	2	248	c.195G>T	c.(193-195)GTG>GTT	p.V65V	ITGA9_uc003chc.2_Silent_p.V65V	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	65	Extracellular (Potential).|FG-GAP 1.				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GGGTCCTTGTGGGCGCACCAA	0.527			NA											6	50					0.000157383	0.000177377	0.00308	1	0
GPX1	2876	broad.mit.edu	37	3	49394909	49394909	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:49394909G>A	uc011bcl.1	-	3	604	c.524C>T	c.(523-525)CCC>CTC	p.P175L	GPX1_uc011bcm.1_3'UTR	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	175					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CCTGCGTAGGGGCACACCGTC	0.617			NA											10	33					0	0	0.001368	0	0
ROBO1	6091	broad.mit.edu	37	3	78666888	78666888	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:78666888C>T	uc003dqe.2	-	27	4387	c.4179G>A	c.(4177-4179)TCG>TCA	p.S1393S	ROBO1_uc003dqb.2_Silent_p.S1354S|ROBO1_uc003dqc.2_Silent_p.S1293S|ROBO1_uc003dqd.2_Silent_p.S1348S|ROBO1_uc010hoh.2_Silent_p.S585S|ROBO1_uc011bgl.1_Silent_p.S965S	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1393	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGGAGCCGTCCGAAGAACTAA	0.577			NA											4	42					0	0	0.000602	0	0
ARL13B	200894	broad.mit.edu	37	3	93761947	93761947	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:93761947A>T	uc003drc.2	+	7	1173	c.887A>T	c.(886-888)GAG>GTG	p.E296V	ARL13B_uc010hop.2_Missense_Mutation_p.E147V|ARL13B_uc003drd.2_Missense_Mutation_p.E189V|ARL13B_uc003dre.2_Missense_Mutation_p.E281V|ARL13B_uc003drf.2_Missense_Mutation_p.E296V|ARL13B_uc003drg.2_Missense_Mutation_p.E193V	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	296							GTP binding				0						ATGGAGCATGAGCAAATAGAG	0.343			NA											3	20					0	0	0.009096	0	0
POLQ	10721	broad.mit.edu	37	3	121209076	121209076	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:121209076C>A	uc003eee.3	-	16	2831	c.2702G>T	c.(2701-2703)TGT>TTT	p.C901F	POLQ_uc003eed.2_Missense_Mutation_p.C73F	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	901					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TAACAGGGCACATGGATTCCA	0.393	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					33	42					1.36615e-20	2.18836e-20	0.002836	1	0
HEG1	57493	broad.mit.edu	37	3	124746163	124746163	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:124746163C>A	uc003ehs.3	-	3	867	c.799G>T	c.(799-801)GAG>TAG	p.E267*	HEG1_uc011bke.1_Nonsense_Mutation_p.E267*	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	267	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						TCTCCCATCTCCAAAGCAGGA	0.552			NA											13	20					0.000219431	0.000246504	0.00245	1	0
PLXND1	23129	broad.mit.edu	37	3	129305058	129305058	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:129305058C>A	uc003emx.2	-	4	1778	c.1678G>T	c.(1678-1680)GGT>TGT	p.G560C		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	560	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TCCGCCGCACCCACGCAGTCC	0.697	Ovarian(97;366 1484 3738 22084 39045)		NA											6	12					0.00448238	0.00481647	0.004482	1	0
COL6A6	131873	broad.mit.edu	37	3	130289965	130289965	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:130289965C>A	uc010htl.2	+	6	2736	c.2705C>A	c.(2704-2706)GCC>GAC	p.A902D		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	902	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TTCACTGAAGCCCGGGGCAGC	0.542			NA											5	23					1.23904e-05	1.47322e-05	0.000602	1	0
COPB2	9276	broad.mit.edu	37	3	139093397	139093397	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:139093397C>T	uc003etf.3	-	7	815	c.685G>A	c.(685-687)GCC>ACC	p.A229T	COPB2_uc011bmv.1_Missense_Mutation_p.A200T|COPB2_uc010hui.2_Missense_Mutation_p.A200T|COPB2_uc011bmw.1_Missense_Mutation_p.A229T	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	229	WD 6.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						ACATTTTGGGCATGTCCTTCC	0.378			NA											7	57					0	0	0.001984	0	0
TRIM42	287015	broad.mit.edu	37	3	140401880	140401880	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:140401880C>T	uc003eto.1	+	2	1109	c.918C>T	c.(916-918)AAC>AAT	p.N306N		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	306	B box-type 2.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						GCAATGACAACAAATTGCTCT	0.562			NA											24	42					0	0	0.002299	0	0
VEPH1	79674	broad.mit.edu	37	3	157031456	157031456	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:157031456T>A	uc003fbj.1	-	11	2281	c.1964A>T	c.(1963-1965)CAC>CTC	p.H655L	VEPH1_uc003fbk.1_Missense_Mutation_p.H655L|VEPH1_uc010hvu.1_Intron	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	655						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TTCAAAGCTGTGAGCACCCCC	0.488			NA											5	45					0	0	0.000602	0	0
UBXN7	26043	broad.mit.edu	37	3	196134252	196134252	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr3:196134252C>T	uc003fwm.3	-	2	161	c.86G>A	c.(85-87)AGT>AAT	p.S29N	UBXN7_uc003fwn.3_Intron|UBXN7_uc010iae.2_Intron|UBXN7_uc010iaf.2_Missense_Mutation_p.S29N	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	29							protein binding			ovary(2)|pancreas(1)	3						TTTTCCTACACTTTCACTTGC	0.378			NA											9	61					0	0	0.004482	0	0
CCKAR	886	broad.mit.edu	37	4	26490886	26490886	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:26490886G>T	uc003gse.1	-	2	486	c.333C>A	c.(331-333)AGC>AGA	p.S111R		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	111	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	TGCAAACGGCGCTCCCGAAGA	0.557			NA											47	591					1.06522e-23	1.72227e-23	0.003214	1	0
KLB	152831	broad.mit.edu	37	4	39408945	39408945	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:39408945G>T	uc003gua.2	+	1	473	c.376G>T	c.(376-378)GGT>TGT	p.G126C	KLB_uc011byj.1_Missense_Mutation_p.G126C	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	126	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						CAGCACGAATGGTTCCAGTGA	0.388			NA											47	102					1.0331e-37	1.7352e-37	0.00361	1	0
FRYL	285527	broad.mit.edu	37	4	48563563	48563563	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:48563563G>A	uc003gyh.1	-	33	4392	c.3787C>T	c.(3787-3789)CTC>TTC	p.L1263F	FRYL_uc003gyk.2_Missense_Mutation_p.L1263F|FRYL_uc003gyi.1_Missense_Mutation_p.L152F	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1263					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						ACAGAATAGAGATGTGGTAGA	0.438			NA											3	32					0	0	0.004672	0	0
CEP135	9662	broad.mit.edu	37	4	56851486	56851486	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:56851486G>T	uc003hbi.2	+	14	2053	c.1819G>T	c.(1819-1821)GAG>TAG	p.E607*	CEP135_uc003hbj.2_Nonsense_Mutation_p.E313*	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	607	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					ATCAGAATTAGAGAAAACTAT	0.289			NA											7	63					8.12818e-05	9.22083e-05	0.001984	1	0
DKK2	27123	broad.mit.edu	37	4	107845182	107845182	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:107845182G>T	uc003hyi.2	-	4	1414	c.709C>A	c.(709-711)CTG>ATG	p.L237M	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	237	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		TTGCAAGACAGGCCCTTCGCA	0.488			NA											18	69					2.35188e-11	3.36261e-11	0.006122	1	0
NDST4	64579	broad.mit.edu	37	4	115856477	115856477	+	Missense_Mutation	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:115856477T>C	uc003ibu.2	-	6	2100	c.1421A>G	c.(1420-1422)CAG>CGG	p.Q474R	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	474	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CCCACAAGTCTGTCGAGGGAG	0.403			NA											5	27					0	0	0.000602	0	0
POU4F2	5458	broad.mit.edu	37	4	147561134	147561134	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:147561134C>T	uc003ikv.2	+	2	652	c.404C>T	c.(403-405)CCC>CTC	p.P135L		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	135					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					CACCACAGCCCCTTCAAACCG	0.647			NA											7	26					0	0	0.00308	0	0
DCHS2	54798	broad.mit.edu	37	4	155219858	155219858	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:155219858C>A	uc003inw.2	-	18	4243	c.4243G>T	c.(4243-4245)GGA>TGA	p.G1415*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1415	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCAGTATTTCCATCTATTAAA	0.323			NA											8	39					3.86212e-05	4.41021e-05	0.008291	1	0
MORF4	10934	broad.mit.edu	37	4	174537370	174537370	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:174537370C>A	uc011cke.1	-	1	425	c.425G>T	c.(424-426)GGC>GTC	p.G142V		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TAGCTGGGTGCCCAACATTAG	0.423			NA											43	132					2.00842e-17	3.1444e-17	0.002522	1	0
AGA	175	broad.mit.edu	37	4	178355600	178355600	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr4:178355600C>A	uc003iuu.1	-	7	804	c.742G>T	c.(742-744)GAC>TAC	p.D248Y	AGA_uc010irt.1_RNA|AGA_uc003iuv.1_3'UTR|AGA_uc003iuw.2_Missense_Mutation_p.D142Y	NM_000027	NP_000018	P20933	ASPG_HUMAN	aspartylglucosaminidase precursor	248					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		GCAGTATCGTCAGCATAGGCT	0.463			NA											9	77					7.48243e-07	9.34628e-07	0.006214	1	0
PRDM9	56979	broad.mit.edu	37	5	23524524	23524524	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:23524524C>T	uc003jgo.2	+	10	1214	c.1032C>T	c.(1030-1032)TGC>TGT	p.C344C		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	344	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATAGAACCTGCCGAGTCATTA	0.547			NA								HNSCC(3;0.000094)			53	63					0	0	0.00361	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33549399	33549399	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:33549399G>T	uc003jia.1	-	21	4378	c.4215C>A	c.(4213-4215)TGC>TGA	p.C1405*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.C1320*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1405	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCAGGAACTGGCAGTGAAATG	0.612			NA								HNSCC(64;0.19)			69	96					1.55545e-33	2.57505e-33	0.00361	1	0
SLC45A2	51151	broad.mit.edu	37	5	33964012	33964012	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:33964012C>A	uc003jid.2	-	3	764	c.672G>T	c.(670-672)TTG>TTT	p.L224F	SLC45A2_uc003jie.2_Missense_Mutation_p.L224F|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	224	Helical; Name=6; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AAGTGAGCACCAATGCAGAGA	0.512	Ovarian(31;380 859 8490 22203 49048)		NA											38	56					3.76114e-14	5.70769e-14	0.004289	1	0
PLCXD3	345557	broad.mit.edu	37	5	41381978	41381978	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:41381978G>T	uc003jmm.1	-	2	864	c.762C>A	c.(760-762)AGC>AGA	p.S254R		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	254					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						TGACCACAGTGCTAGCTTTGG	0.393			NA											22	96					7.92952e-12	1.14317e-11	0.003954	1	0
ERBB2IP	55914	broad.mit.edu	37	5	65349306	65349306	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:65349306C>G	uc003juk.1	+	21	2468	c.2160C>G	c.(2158-2160)TTC>TTG	p.F720L	ERBB2IP_uc003jui.1_Missense_Mutation_p.F720L|ERBB2IP_uc003juj.1_Missense_Mutation_p.F720L|ERBB2IP_uc011cqx.1_Missense_Mutation_p.F720L|ERBB2IP_uc011cqy.1_Missense_Mutation_p.F720L|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.F716L|ERBB2IP_uc003jul.1_Missense_Mutation_p.F716L	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	720					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGGAAAAGTTCAAAGCTCATG	0.289			NA											12	75					0	0	0.001368	0	0
CARTPT	9607	broad.mit.edu	37	5	71015107	71015107	+	Translation_Start_Site	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:71015107C>T	uc003kbv.1	+	1	114	c.-13C>T	c.(-15--11)GACGA>GATGA			NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript						activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	CCAGCAACGACGAGTTTCAGA	0.652			NA											13	66					0	0	0.001855	0	0
ZNF366	167465	broad.mit.edu	37	5	71756824	71756824	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:71756824G>T	uc003kce.1	-	2	686	c.500C>A	c.(499-501)ACT>AAT	p.T167N		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CAGGAATGGAGTGGGCGTTGG	0.642			NA											25	86					6.36457e-07	8.03702e-07	0.003954	1	0
PAM	5066	broad.mit.edu	37	5	102326096	102326097	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:102326096_102326097GG>TT	uc003knw.2	+	15	1977_1978	c.1604_1605GG>TT	c.(1603-1605)TGG>TTT	p.W535F	PAM_uc003kns.2_Missense_Mutation_p.W428F|PAM_uc003knt.2_Missense_Mutation_p.W535F|PAM_uc003knu.2_Missense_Mutation_p.W535F|PAM_uc003knv.2_Missense_Mutation_p.W535F|PAM_uc011cuz.1_Missense_Mutation_p.W438F|PAM_uc003knx.1_Missense_Mutation_p.W138F	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	535	Peptidyl-alpha-hydroxyglycine alpha- amidating lyase (By similarity).|NHL 1.|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	GACCATGTCTGGGATGGAAAGT	0.371			NA											3	17					0	0	0.004672	0	0
PRR16	51334	broad.mit.edu	37	5	120021716	120021716	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:120021716A>T	uc003ksq.2	+	2	390	c.227A>T	c.(226-228)AAA>ATA	p.K76I	PRR16_uc003ksp.2_Missense_Mutation_p.K53I|PRR16_uc003ksr.2_Missense_Mutation_p.K6I	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	76										pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		GACAGCTCCAAAACGGACACG	0.493			NA											10	42					0	0	0.008291	0	0
SLC22A4	6583	broad.mit.edu	37	5	131630391	131630391	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:131630391A>G	uc003kwq.2	+	1	247	c.82A>G	c.(82-84)AGC>GGC	p.S28G	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	28	Helical; Name=1; (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GCTCAGCGCCAGCATCATCCC	0.657			NA											10	41					0	0	0.000978	0	0
TIFAB	497189	broad.mit.edu	37	5	134785609	134785609	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:134785609G>T	uc003law.3	-	2	222	c.21C>A	c.(19-21)GTC>GTA	p.V7V	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	7											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCACTCGCAGGACGGTGAGGG	0.602			NA											16	58					5.3912e-06	6.52223e-06	0.006122	1	0
CDC25C	995	broad.mit.edu	37	5	137627777	137627777	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:137627777G>T	uc003lcp.1	-	8	915	c.644C>A	c.(643-645)CCG>CAG	p.P215Q	CDC25C_uc003lcq.1_Missense_Mutation_p.P142Q|CDC25C_uc003lcr.1_Missense_Mutation_p.P215Q|CDC25C_uc011cyp.1_Missense_Mutation_p.P232Q|CDC25C_uc003lcs.1_Missense_Mutation_p.P293Q	NM_001790	NP_001781	P30307	MPIP3_HUMAN	cell division cycle 25C isoform a	215					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			lung(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TGGCATCGACGGGGAGCGATA	0.333			NA											22	87					2.70639e-06	3.32061e-06	0.002299	1	0
ITK	3702	broad.mit.edu	37	5	156671307	156671307	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:156671307G>T	uc003lwo.1	+	13	1350	c.1268G>T	c.(1267-1269)GGG>GTG	p.G423V		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	423	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAGCTGTATGGGGTGTGCCTG	0.522	Esophageal Squamous(70;1378 1469 8785 19883)		NA	T	SYK	peripheral T-cell lymphoma								9	42					3.07112e-06	3.75479e-06	0.000978	1	0
ATP10B	23120	broad.mit.edu	37	5	160025868	160025868	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:160025868G>T	uc003lym.1	-	22	4320	c.3473C>A	c.(3472-3474)CCT>CAT	p.P1158H	ATP10B_uc010jit.1_Intron	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1158	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GACAAGAGGAGGCAAGGAGGT	0.458			NA											43	107					6.5261e-18	1.03106e-17	0.00874	1	0
GABRA1	2554	broad.mit.edu	37	5	161300189	161300189	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:161300189A>G	uc010jiw.2	+	6	790	c.322A>G	c.(322-324)ATG>GTG	p.M108V	GABRA1_uc010jix.2_Missense_Mutation_p.M108V|GABRA1_uc010jiy.2_Missense_Mutation_p.M108V|GABRA1_uc003lyx.3_Missense_Mutation_p.M108V|GABRA1_uc010jiz.2_Missense_Mutation_p.M108V|GABRA1_uc010jja.2_Missense_Mutation_p.M108V|GABRA1_uc010jjb.2_Missense_Mutation_p.M108V	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	108	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TAAAGGACCTATGACAGTCCT	0.383			NA											11	67					0	0	0.000978	0	0
ODZ2	57451	broad.mit.edu	37	5	167674702	167674702	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:167674702G>T	uc010jjd.2	+	27	6731	c.6731G>T	c.(6730-6732)CGG>CTG	p.R2244L	ODZ2_uc003lzr.3_Missense_Mutation_p.R2014L|ODZ2_uc003lzt.3_Missense_Mutation_p.R1617L|ODZ2_uc010jje.2_Missense_Mutation_p.R1508L	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CTCCGGGATCGGATAACCAGA	0.532			NA											17	40					4.75885e-15	7.41694e-15	0.00499	1	0
ZNF454	285676	broad.mit.edu	37	5	178392679	178392679	+	Nonsense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:178392679C>G	uc003mjo.1	+	5	1545	c.1274C>G	c.(1273-1275)TCA>TGA	p.S425*	ZNF454_uc010jkz.1_Nonsense_Mutation_p.S425*	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	425	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		CGGGACCAATCAGCACTAGCC	0.433			NA											9	26					0	0	0.004482	0	0
OR2V2	285659	broad.mit.edu	37	5	180582665	180582665	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr5:180582665C>T	uc011dhj.1	+	1	723	c.723C>T	c.(721-723)ACC>ACT	p.T241T		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCTGGCCACCTGCTCCTCCC	0.577			NA											14	76					0	0	0.00245	0	0
RREB1	6239	broad.mit.edu	37	6	7229815	7229815	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:7229815G>T	uc003mxc.2	+	10	1873	c.1483G>T	c.(1483-1485)GCC>TCC	p.A495S	RREB1_uc003mxb.2_Missense_Mutation_p.A495S|RREB1_uc010jnx.2_Missense_Mutation_p.A495S	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	495	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GGCCCCTGCCGCCCCACTGCA	0.642			NA											27	502					6.07407e-21	9.77502e-21	0.007291	1	0
ATXN1	6310	broad.mit.edu	37	6	16327906	16327906	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:16327906C>A	uc003nbt.2	-	8	1607	c.636G>T	c.(634-636)CAG>CAT	p.Q212H	ATXN1_uc010jpi.2_Missense_Mutation_p.Q212H|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	212	Poly-Gln.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				gctgctgctgctgatgctgat	0.383			NA											3	19					0.004672	0.00500468	0.004672	1	0
HIST1H3C	8352	broad.mit.edu	37	6	26045648	26045648	+	Missense_Mutation	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:26045648A>G	uc003nfv.2	+	1	10	c.10A>G	c.(10-12)ACG>GCG	p.T4A	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	4					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						AATGGCTCGTACGAAGCAAAC	0.502			NA											12	67					0	0	0.001855	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26107828	26107828	+	Missense_Mutation	SNP	C	C	T	rs143795730		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:26107828C>T	uc003ngj.2	-	1	537	c.494G>A	c.(493-495)AGG>AAG	p.R165K		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	165					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TCTCCCGCTCCTAACAGTTTT	0.478			NA											16	146					0	0	0.00499	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833185	27833185	+	Missense_Mutation	SNP	G	G	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:27833185G>C	uc003njw.2	+	1	79	c.53G>C	c.(52-54)CGC>CCC	p.R18P		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	18					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GCCAAGACCCGCTCTTCTCGT	0.632			NA											24	128					0	0	0.004656	0	0
OR2B2	81697	broad.mit.edu	37	6	27879515	27879515	+	Missense_Mutation	SNP	T	T	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:27879515T>G	uc011dkw.1	-	1	583	c.583A>C	c.(583-585)AAT>CAT	p.N195H		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCAGCCTCATTTGCTGTTGTG	0.433			NA											15	84					0	0	0.00245	0	0
C6orf138	442213	broad.mit.edu	37	6	47846204	47846204	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:47846204C>A	uc011dwm.1	-	3	2410	c.2325G>T	c.(2323-2325)GGG>GGT	p.G775G	C6orf138_uc011dwn.1_Silent_p.G539G	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	792	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GTGTGCAACCCCCAGTGAGCA	0.428			NA											5	61					1.23904e-05	1.47322e-05	0.000602	1	0
GFRAL	389400	broad.mit.edu	37	6	55214912	55214912	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:55214912C>G	uc003pcm.1	+	4	425	c.339C>G	c.(337-339)TTC>TTG	p.F113L		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	113	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGGATAAATTCAAATGGAATC	0.303			NA											11	47					0	0	0.000978	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55364050	55364050	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:55364050G>T	uc003pcn.2	-	7	839	c.680C>A	c.(679-681)CCG>CAG	p.P227Q	HMGCLL1_uc003pco.2_Missense_Mutation_p.P197Q|HMGCLL1_uc010jzx.2_Missense_Mutation_p.P98Q|HMGCLL1_uc011dxc.1_Missense_Mutation_p.P165Q|HMGCLL1_uc011dxd.1_Intron|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	227							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CACTTTTTGCGGTGTAATACT	0.318	Ovarian(35;840 893 7837 15538 42887)		NA											7	68					3.86212e-05	4.41021e-05	0.008291	1	0
DST	667	broad.mit.edu	37	6	56457018	56457018	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:56457018C>T	uc003pdf.2	-	43	6536	c.6508G>A	c.(6508-6510)GAC>AAC	p.D2170N	DST_uc003pcz.3_Missense_Mutation_p.D1992N|DST_uc011dxj.1_Missense_Mutation_p.D2021N|DST_uc011dxk.1_Missense_Mutation_p.D2032N|DST_uc003pcy.3_Missense_Mutation_p.D1666N|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4078	Spectrin 3.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTTTGGGGTCCACCGCAATA	0.433			NA											11	10					0	0	0.001855	0	0
COL12A1	1303	broad.mit.edu	37	6	75848603	75848603	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:75848603C>T	uc003phs.2	-	28	5198	c.5032G>A	c.(5032-5034)GGA>AGA	p.G1678R	COL12A1_uc003pht.2_Missense_Mutation_p.G514R	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1678	Fibronectin type-III 12.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TCTGAAGCTCCATGATCCCAA	0.438			NA											10	20					0	0	0.006214	0	0
TBX18	9096	broad.mit.edu	37	6	85453977	85453977	+	Splice_Site	SNP	A	A	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr6:85453977A>C	uc003pkl.1	-	6	1004	c.1004_splice	c.e6+1	p.R335_splice	TBX18_uc010kbq.1_Splice_Site_p.R177_splice	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18						multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		ACTAAGGCCCACCTGTTGCGC	0.338			NA											13	4					0	0	0.00245	0	0
AMZ1	155185	broad.mit.edu	37	7	2740255	2740255	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:2740255C>T	uc003smr.1	+	2	531	c.170C>T	c.(169-171)ACC>ATC	p.T57I	AMZ1_uc003sms.1_Missense_Mutation_p.T57I|AMZ1_uc011jwa.1_5'Flank	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	57							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CTCTTCTGCACCCTGCTCATC	0.677			NA											40	122					0	0	0.005524	0	0
ZNF12	7559	broad.mit.edu	37	7	6731811	6731811	+	Silent	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:6731811C>T	uc003sqt.1	-	5	1316	c.762G>A	c.(760-762)TCG>TCA	p.S254S	ZNF12_uc011jxa.1_Silent_p.S92S|ZNF12_uc003sqs.1_Silent_p.S216S	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	254					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CAGTGAGGTCCGACATCTGGA	0.383			NA											13	20					0	0	0.001368	0	0
HDAC9	9734	broad.mit.edu	37	7	18788664	18788664	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:18788664G>T	uc003suh.2	+	13	1978	c.1937G>T	c.(1936-1938)TGC>TTC	p.C646F	HDAC9_uc003sue.2_Missense_Mutation_p.C646F|HDAC9_uc011jyd.1_Missense_Mutation_p.C646F|HDAC9_uc003sui.2_Missense_Mutation_p.C649F|HDAC9_uc003suj.2_Missense_Mutation_p.C605F|HDAC9_uc003sua.1_Missense_Mutation_p.C624F|HDAC9_uc010kue.1_Missense_Mutation_p.C301F	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	646	Histone deacetylase.			HQCV -> KPNS (in Ref. 8; AAF04254).	B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	AAACACCAGTGCGTTTGTGGC	0.448			NA											6	26					2.7689e-08	3.65663e-08	0.001984	1	0
HECW1	23072	broad.mit.edu	37	7	43484944	43484944	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:43484944G>A	uc003tid.1	+	11	2778	c.2173G>A	c.(2173-2175)GCC>ACC	p.A725T	HECW1_uc011kbi.1_Missense_Mutation_p.A725T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	725					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CGTGGACAGCGCCAAGATCTC	0.627			NA											18	92					0	0	0.007413	0	0
COBL	23242	broad.mit.edu	37	7	51261079	51261079	+	Silent	SNP	A	A	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:51261079A>G	uc003tpr.3	-	3	638	c.453T>C	c.(451-453)CCT>CCC	p.P151P	COBL_uc003tps.2_Silent_p.P151P|COBL_uc011kcl.1_Silent_p.P151P|COBL_uc010kzc.2_Silent_p.P151P|COBL_uc003tpt.2_Silent_p.P151P|COBL_uc003tpp.3_5'Flank|COBL_uc003tpq.3_Silent_p.P67P	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	151										skin(3)|ovary(2)	5	Glioma(55;0.08)					TACTAACCTCAGGCACCTTAG	0.463	NSCLC(189;2119 2138 12223 30818 34679)		NA											6	22					0	0	0.001168	0	0
CACNA2D1	781	broad.mit.edu	37	7	81579728	81579728	+	Missense_Mutation	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:81579728T>A	uc003uhr.1	-	39	3512	c.3256A>T	c.(3256-3258)AGC>TGC	p.S1086C	uc003uhq.1_5'Flank|CACNA2D1_uc011kgy.1_Missense_Mutation_p.S298C	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	1098	Cytoplasmic (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CGGTGTGTGCTGCCAGATACC	0.448			NA											14	60					0	0	0.004007	0	0
TMEM130	222865	broad.mit.edu	37	7	98460868	98460868	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:98460868G>A	uc003upo.2	-	2	430	c.241C>T	c.(241-243)CTT>TTT	p.L81F	TMEM130_uc011kiq.1_Missense_Mutation_p.L62F|TMEM130_uc011kir.1_Missense_Mutation_p.L81F|TMEM130_uc003upn.2_Intron	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	81	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTGCCAGTAAGCACCAGCGGG	0.657			NA											15	24					0	0	0.003163	0	0
C7orf51	222950	broad.mit.edu	37	7	100084640	100084640	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:100084640G>A	uc003uvd.1	+	3	424	c.265G>A	c.(265-267)GGC>AGC	p.G89S	C7orf51_uc003uve.1_5'Flank	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	89										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCACTCGGTGGGCAGCATGGA	0.711			NA											8	18					0	0	0.006214	0	0
LAMB4	22798	broad.mit.edu	37	7	107756519	107756519	+	Missense_Mutation	SNP	G	G	T	rs140462508	byFrequency	TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:107756519G>T	uc010ljo.1	-	3	206	c.122C>A	c.(121-123)ACG>AAG	p.T41K	LAMB4_uc003vey.2_Missense_Mutation_p.T41K	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	41	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CATAAGCTGCGTGTTCCTGCC	0.522			NA											15	99					1.3612e-06	1.69416e-06	0.003163	1	0
EIF3IP1	442720	broad.mit.edu	37	7	109599884	109599884	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:109599884C>A	uc003vfp.1	-	1	387	c.214G>T	c.(214-216)GTG>TTG	p.V72L		NR_003024				Homo sapiens eukaryotic translation initiation factor 3, subunit I pseudogene 1 (EIF3IP1), non-coding RNA.												0						AAGAAGCTCACAAAGCACTGA	0.463			NA											11	12					3.86212e-05	4.41021e-05	0.008291	1	0
FAM131B	9715	broad.mit.edu	37	7	143053838	143053838	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:143053838C>A	uc003wct.2	-	6	2510	c.804G>T	c.(802-804)CTG>CTT	p.L268L	FAM131B_uc010loz.2_Silent_p.L236L|FAM131B_uc003wcu.3_Silent_p.L268L|FAM131B_uc010lpa.2_Silent_p.L296L	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	268											0	Melanoma(164;0.205)					GGCCCCTTGCCAGGTCCACTG	0.632			NA											24	172					5.45024e-15	8.45643e-15	0.00333	1	0
OR2A25	392138	broad.mit.edu	37	7	143771460	143771460	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:143771460C>A	uc011ktx.1	+	1	148	c.148C>A	c.(148-150)CTG>ATG	p.L50M		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GCTCATCTCACTGGACTCCAG	0.562			NA											10	93					4.68919e-08	6.12249e-08	0.008291	1	0
ZNF467	168544	broad.mit.edu	37	7	149462585	149462585	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr7:149462585C>A	uc003wgd.2	-	5	1147	c.1006G>T	c.(1006-1008)GCT>TCT	p.A336S	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGAGGAGAAGCGGACGAGTCG	0.657			NA											5	9					0.00116845	0.00127534	0.001168	1	0
CSMD1	64478	broad.mit.edu	37	8	2824155	2824155	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:2824155C>G	uc011kwk.1	-	58	9430	c.9040G>C	c.(9040-9042)GGG>CGG	p.G3014R	CSMD1_uc011kwj.1_Missense_Mutation_p.G2343R|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3014	Extracellular (Potential).|Sushi 23.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTCATGAGCCCTGAGGTCTTG	0.537			NA											9	14					0	0	0.004482	0	0
EFHA2	286097	broad.mit.edu	37	8	16942779	16942779	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:16942779G>T	uc003wxd.2	+	6	771	c.729G>T	c.(727-729)ATG>ATT	p.M243I		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	243	EF-hand 1.					integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		CTTTCAACATGTTTGACACTG	0.328	Pancreas(177;1461 2846 10523 14242)|Colon(184;2703 2719 18484 23400)		NA											8	50					1.58986e-06	1.95763e-06	0.008291	1	0
ADAM7	8756	broad.mit.edu	37	8	24342843	24342843	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:24342843G>T	uc003xeb.2	+	10	1042	c.929G>T	c.(928-930)TGC>TTC	p.C310F	ADAM7_uc003xec.2_Missense_Mutation_p.C82F	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	310	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GGGGGTATGTGCCTGCCCTAT	0.358			NA											35	43					4.00102e-26	6.52996e-26	0.00623	1	0
WRN	7486	broad.mit.edu	37	8	30924680	30924680	+	Silent	SNP	T	T	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:30924680T>C	uc003xio.3	+	6	1424	c.636T>C	c.(634-636)TAT>TAC	p.Y212Y		NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	212	Interaction with WRNIP1 (By similarity).|3'-5' exonuclease.			Y->F: Strongly reduces exonuclease activity.	base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AGAAACTGTATGCAGCCACTG	0.343	Ovarian(18;161 598 2706 14834 27543)		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				5	44					0	0	0.001168	0	0
LOC728024	728024	broad.mit.edu	37	8	37605155	37605155	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:37605155C>T	uc010lvx.1	-	1	367	c.221G>A	c.(220-222)GGC>GAC	p.G74D	ERLIN2_uc003xke.3_Intron	NR_003671				SubName: Full=cDNA FLJ38978 fis, clone NT2RI2004209; SubName: Full=Chromosome X open reading frame 56, isoform CRA_b; SubName: Full=Putative uncharacterized protein CXorf56;												0						AAAGCCCTGGCCAAACTTGAC	0.468			NA											58	45					0	0	0.00361	0	0
CYP7A1	1581	broad.mit.edu	37	8	59407086	59407086	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:59407086G>T	uc003xtm.3	-	4	1081	c.1018C>A	c.(1018-1020)CTG>ATG	p.L340M		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	340					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AGGTCATTCAGTTCTGCTTGA	0.328			NA							Neonatal_Giant_Cell_Hepatitis				6	53					0.00116845	0.00127534	0.001168	1	0
CPA6	57094	broad.mit.edu	37	8	68423860	68423860	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:68423860C>A	uc003xxq.3	-	4	604	c.348G>T	c.(346-348)CTG>CTT	p.L116L	CPA6_uc003xxr.3_5'UTR|CPA6_uc003xxs.2_Silent_p.L116L	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	116					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			TTCCCTTCTCCAGTGTTTTCT	0.383			NA											27	236					9.39395e-14	1.41318e-13	0.00632	1	0
ZFHX4	79776	broad.mit.edu	37	8	77618376	77618376	+	Missense_Mutation	SNP	A	A	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:77618376A>T	uc003yav.2	+	2	2440	c.2053A>T	c.(2053-2055)AGG>TGG	p.R685W	ZFHX4_uc003yat.1_Missense_Mutation_p.R685W|ZFHX4_uc003yau.1_Missense_Mutation_p.R685W|ZFHX4_uc003yaw.1_Missense_Mutation_p.R685W	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	685						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTCACCCCAGGCTTGCCCG	0.502			NA								HNSCC(33;0.089)			6	77					0	0	0.001168	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026891	93026891	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:93026891C>A	uc003yfd.2	-	3	468	c.384G>T	c.(382-384)AGG>AGT	p.R128S	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R101S|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R91S|RUNX1T1_uc010mao.2_Missense_Mutation_p.R101S|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R139S|RUNX1T1_uc003yfh.1_Missense_Mutation_p.R91S|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R91S|RUNX1T1_uc003yff.1_Missense_Mutation_p.R91S|RUNX1T1_uc003yfg.1_Missense_Mutation_p.R91S	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	128	TAFH.			R->D: Loss of interaction with TCF12.	generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TAGTAAGGAACCTTTTCAGCT	0.522			NA											29	106					7.26314e-15	1.1219e-14	0.007291	1	0
GRHL2	79977	broad.mit.edu	37	8	102570830	102570830	+	Silent	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:102570830G>T	uc010mbu.2	+	4	798	c.468G>T	c.(466-468)ACG>ACT	p.T156T	GRHL2_uc011lhi.1_Silent_p.T156T	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	156						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			CGGGAATCACGGTGGTGAAAG	0.522			NA											79	76					1.63007e-36	2.71156e-36	0.00361	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110451174	110451174	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:110451174C>G	uc003yne.2	+	32	3913	c.3809C>G	c.(3808-3810)ACA>AGA	p.T1270R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1270	Extracellular (Potential).|IPT/TIG 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AATGAACTCACACAAAACATG	0.343			NA								HNSCC(38;0.096)			50	30					0	0	0.00361	0	0
CSMD3	114788	broad.mit.edu	37	8	113275890	113275890	+	Missense_Mutation	SNP	A	A	C			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:113275890A>C	uc003ynu.2	-	61	9999	c.9840T>G	c.(9838-9840)AGT>AGG	p.S3280R	CSMD3_uc003yns.2_Missense_Mutation_p.S2482R|CSMD3_uc003ynt.2_Missense_Mutation_p.S3240R|CSMD3_uc011lhx.1_Missense_Mutation_p.S3111R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3280	Sushi 25.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTACTTCACCACTCCAGGTAC	0.393			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	41					0	0	0.001984	0	0
COL14A1	7373	broad.mit.edu	37	8	121259915	121259915	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:121259915C>T	uc003yox.2	+	21	2808	c.2543C>T	c.(2542-2544)ACG>ATG	p.T848M	COL14A1_uc003yoy.2_Missense_Mutation_p.T526M	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	848	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TTGCGCATTACGTGGGACCCC	0.468			NA											38	84					0	0	0.007835	0	0
TBC1D2	55357	broad.mit.edu	37	9	100971119	100971119	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr9:100971119C>T	uc011lvb.1	-	9	2161	c.1981G>A	c.(1981-1983)GCC>ACC	p.A661T	TBC1D2_uc004ayp.2_Missense_Mutation_p.A201T|TBC1D2_uc004ayq.2_Missense_Mutation_p.A661T|TBC1D2_uc004ayr.2_Missense_Mutation_p.A443T|TBC1D2_uc004ayo.3_Missense_Mutation_p.A661T	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	661	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		TGCTCGCGGGCCTGGCCCCGG	0.652			NA											9	37					0	0	0.006214	0	0
ABCA1	19	broad.mit.edu	37	9	107602707	107602707	+	Missense_Mutation	SNP	C	C	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr9:107602707C>T	uc004bcl.2	-	9	1220	c.907G>A	c.(907-909)GCT>ACT	p.A303T		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	303	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CGAGACACAGCCTGGTAGATT	0.537			NA											10	34					0	0	0.008291	0	0
KIAA0368	23392	broad.mit.edu	37	9	114134778	114134778	+	Missense_Mutation	SNP	C	C	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr9:114134778C>G	uc004bfe.1	-	43	4993	c.4993G>C	c.(4993-4995)GCT>CCT	p.A1665P		NM_001080398	NP_001073867			KIAA0368 protein												0						TCCTCATCAGCAATTTCATGC	0.413			NA											12	47					0	0	0.000978	0	0
DNAJC25	548645	broad.mit.edu	37	9	114411817	114411817	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr9:114411817G>A	uc004bfl.2	+	3	630	c.574G>A	c.(574-576)GCC>ACC	p.A192T	DNAJC25-GNG10_uc004bfn.2_Intron|DNAJC25_uc004bfm.2_Missense_Mutation_p.A70T	NM_001015882	NP_001015882	Q9H1X3	DJC25_HUMAN	DnaJ (Hsp40) homolog, subfamily C , member 25	192					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding				0						TACAGAGATTGCCAAGCAGCA	0.413			NA											5	12					0	0	0.000602	0	0
OR1N2	138882	broad.mit.edu	37	9	125316283	125316284	+	Missense_Mutation	DNP	CC	CC	AA	rs142706201		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr9:125316283_125316284CC>AA	uc011lyx.1	+	1	835_836	c.835_836CC>AA	c.(835-837)CCT>AAT	p.P279N		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	279	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						GTATTTACTTCCTCCATCAACT	0.46			NA											17	51					0	0	0.004672	0	0
OR1K1	392392	broad.mit.edu	37	9	125562914	125562914	+	Silent	SNP	T	T	G			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr9:125562914T>G	uc011lze.1	+	1	513	c.513T>G	c.(511-513)GCT>GCG	p.A171A		NM_080859	NP_543135	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTTCTGTGCTTCCCACCAAG	0.607			NA											28	63					0	0	0.008361	0	0
CRB2	286204	broad.mit.edu	37	9	126125320	126125320	+	Missense_Mutation	SNP	G	G	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr9:126125320G>A	uc004bnx.1	+	2	363	c.271G>A	c.(271-273)GGC>AGC	p.G91S	CRB2_uc004bnw.1_Missense_Mutation_p.G91S	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	91	Extracellular (Potential).|EGF-like 1.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						AGATCCCACCGGCTTCCGCTG	0.692			NA											8	40					0	0	0.004482	0	0
MAGEB4	4115	broad.mit.edu	37	X	30260330	30260330	+	Missense_Mutation	SNP	G	G	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chrX:30260330G>T	uc004dcb.2	+	1	162	c.78G>T	c.(76-78)AAG>AAT	p.K26N	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	26										ovary(1)	1						AGGATCTCAAGGTTGGTCAGC	0.562			NA											16	4					6.31663e-08	8.12473e-08	0.003163	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873753	91873753	+	Silent	SNP	T	T	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chrX:91873753T>A	uc004efk.1	+	7	4703	c.3858T>A	c.(3856-3858)GCT>GCA	p.A1286A	PCDH11X_uc004efl.1_Silent_p.A1276A|PCDH11X_uc004efo.1_Silent_p.A1249A|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Silent_p.A1278A|PCDH11X_uc004efn.1_Silent_p.A1268A	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1286	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TGCAAGGTGCTGATGGGCTAT	0.488	NSCLC(38;925 1092 2571 38200 45895)		NA											59	123					0	0	0.00361	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249424	119249424	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chrX:119249424C>A	uc004esk.1	-	1	424	c.349G>T	c.(349-351)GAG>TAG	p.E117*	uc004esi.1_Intron	NM_139282	NP_644811	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	117	Homeobox.				gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTTTCCAGCTCCTCCACCTGC	0.617			NA											50	25					1.46156e-29	2.40809e-29	0.00361	1	0
GPR112	139378	broad.mit.edu	37	X	135430302	135430302	+	Silent	SNP	A	A	C	rs149471297		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chrX:135430302A>C	uc004ezu.1	+	6	4728	c.4437A>C	c.(4435-4437)ACA>ACC	p.T1479T	GPR112_uc010nsb.1_Silent_p.T1274T|GPR112_uc010nsc.1_Silent_p.T1246T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1479	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACGGTTTTACAGTTCTCTCCG	0.443			NA											63	41					0	0	0.00361	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904123	144904123	+	Silent	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chrX:144904123C>A	uc004fcd.2	+	5	1170	c.180C>A	c.(178-180)CCC>CCA	p.P60P	SLITRK2_uc010nsp.2_Silent_p.P60P|SLITRK2_uc010nso.2_Silent_p.P60P|SLITRK2_uc011mwq.1_Silent_p.P60P|SLITRK2_uc011mwr.1_Silent_p.P60P|SLITRK2_uc011mws.1_Silent_p.P60P|SLITRK2_uc004fcg.2_Silent_p.P60P|SLITRK2_uc011mwt.1_Silent_p.P60P	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	60	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGCCCCCCCAGTATCGAA	0.433			NA											24	8					1.10513e-12	1.63409e-12	0.002299	1	0
SLITRK2	84631	broad.mit.edu	37	X	144906140	144906140	+	Missense_Mutation	SNP	C	C	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chrX:144906140C>A	uc004fcd.2	+	5	3187	c.2197C>A	c.(2197-2199)CCT>ACT	p.P733T	SLITRK2_uc010nsp.2_Missense_Mutation_p.P733T|SLITRK2_uc010nso.2_Missense_Mutation_p.P733T|SLITRK2_uc011mwq.1_Missense_Mutation_p.P733T|SLITRK2_uc011mwr.1_Missense_Mutation_p.P733T|SLITRK2_uc011mws.1_Missense_Mutation_p.P733T|SLITRK2_uc004fcg.2_Missense_Mutation_p.P733T|SLITRK2_uc011mwt.1_Missense_Mutation_p.P733T|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	733	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GCCAGCCACACCTGCTTACAC	0.483			NA											55	39					1.57914e-17	2.48356e-17	0.00361	1	0
SEC24C	9632	broad.mit.edu	37	10	75506613	75506614	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:75506613_75506614insA	uc001juw.2	+	3	202_203	c.23_24insA	c.(22-24)CCAfs	p.P8fs	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_5'UTR|SEC24C_uc001jux.2_Frame_Shift_Ins_p.P8fs|SEC24C_uc010qko.1_5'UTR|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	8					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					CAGTCAGTTCCACCTGTGCCAC	0.495			NA											18	72	---	---	---	---	NA	NA	NA	NA	NA
ZNF511	118472	broad.mit.edu	37	10	135125341	135125342	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr10:135125341_135125342insAT	uc001lml.1	+	5	701_702	c.676_677insAT	c.(676-678)CATfs	p.H226fs	TUBGCP2_uc001lmg.1_5'Flank|TUBGCP2_uc010qvc.1_5'Flank|TUBGCP2_uc009ybk.1_5'Flank|TUBGCP2_uc010qvd.1_5'Flank|TUBGCP2_uc001lmh.1_RNA|ZNF511_uc001lmj.1_Frame_Shift_Ins_p.H226fs|ZNF511_uc001lmk.1_3'UTR|ZNF511_uc001lmm.1_RNA			Q8NB15	ZN511_HUMAN	SubName: Full=cDNA FLJ78327; SubName: Full=Zinc finger protein 511, isoform CRA_d;	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		GATCTACAGACATAGGTCAGTG	0.574			NA											26	111	---	---	---	---	NA	NA	NA	NA	NA
PRB3	5544	broad.mit.edu	37	12	11420746	11420746	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:11420746delG	uc001qzs.2	-	3	475	c.437delC	c.(436-438)CCAfs	p.P146fs	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	146	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|5.|Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TCCTCCTTGTGGGGGTGGTCC	0.652			NA											8	150	---	---	---	---	NA	NA	NA	NA	NA
PRB3	5544	broad.mit.edu	37	12	11420809	11420809	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:11420809delG	uc001qzs.2	-	3	412	c.374delC	c.(373-375)CCAfs	p.P125fs	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	125	4.|10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TCCTCCTTGTGGGGGTGGTCC	0.647			NA											32	243	---	---	---	---	NA	NA	NA	NA	NA
SNW1	22938	broad.mit.edu	37	14	78205113	78205127	+	Splice_Site	DEL	ATTCATACCGGATAT	ATTCATACCGGATAT	-			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	ATTCATACCGGATAT	ATTCATACCGGATAT	-	-	ATTCATACCGGATAT	ATTCATACCGGATAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr14:78205113_78205127delATTCATACCGGATAT	uc001xuf.2	-	5	560	c.533_splice	c.e5+1	p.R178_splice	SNW1_uc010tvm.1_Splice_Site_p.R103_splice|SNW1_uc010asu.2_Splice_Site_p.R16_splice|SNW1_uc010tvn.1_Splice_Site_p.R178_splice	NM_012245	NP_036377	Q13573	SNW1_HUMAN	SKI-interacting protein						negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		TCTAGGCATGATTCATACCGGATATACTGAGCAGG	0.423			NA											10	34	---	---	---	---	NA	NA	NA	NA	NA
RHCG	51458	broad.mit.edu	37	15	90023607	90023608	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr15:90023607_90023608insT	uc002bnz.2	-	4	578_579	c.554_555insA	c.(553-555)CACfs	p.H185fs	RHCG_uc002bny.2_5'Flank|RHCG_uc002boa.2_RNA|RHCG_uc010bnq.1_Frame_Shift_Ins_p.H69fs	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	185	Helical; (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					CGCCAAATGTGTGGATGGTCAT	0.579			NA											21	100	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	17	78291021	78291021	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr17:78291021delG	uc002jyf.2	+	16	2988	c.2845delG	c.(2845-2847)GCGfs	p.A949fs	uc002jyg.1_Frame_Shift_Del_p.A680fs	NM_020954	NP_066005			hypothetical protein LOC57714												NA						CCAATTCCCCGCGGAGCATGG	0.562			NA											15	61	---	---	---	---	NA	NA	NA	NA	NA
XIRP2	129446	broad.mit.edu	37	2	168106663	168106664	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:168106663_168106664delAC	uc002udx.2	+	8	8779_8780	c.8761_8762delAC	c.(8761-8763)ACAfs	p.T2921fs	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Frame_Shift_Del_p.T2746fs|XIRP2_uc010fpq.2_Frame_Shift_Del_p.T2699fs|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Frame_Shift_Del_p.T267fs	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2746					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCAAGAGATTACACAGAACAAA	0.381			NA											9	53	---	---	---	---	NA	NA	NA	NA	NA
ZSWIM2	151112	broad.mit.edu	37	2	187692746	187692746	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr2:187692746delC	uc002upu.1	-	9	1907	c.1867delG	c.(1867-1869)GAGfs	p.E623fs		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	623					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			AAAGATAGCTCAGTACTTTTT	0.279			NA											8	24	---	---	---	---	NA	NA	NA	NA	NA
FER1L6	654463	broad.mit.edu	37	8	124975538	124975538	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr8:124975538delG	uc003yqw.2	+	3	303	c.97delG	c.(97-99)GCAfs	p.A33fs		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	33	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGACACTGAAGCACTGCAGGA	0.493			NA											17	110	---	---	---	---	NA	NA	NA	NA	NA
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-50-7109-01A-11D-2036-08	TCGA-50-7109-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5efb21c5-9c0b-4442-b0cb-3c30b0869dba	49a93a1d-94d7-47f8-8e42-1585bde5d3ac	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	14	NA	NA	NA	NA	0.0381472	0.0393998	0.00308	1	1