Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1751	85452	broad.mit.edu	37	1	1920356	1920356	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:1920356C>T	uc001aim.1	-	3	280	c.124G>A	c.(124-126)GAG>AAG	p.E42K	KIAA1751_uc009vkz.1_Missense_Mutation_p.E42K|KIAA1751_uc001ain.1_Missense_Mutation_p.E42K	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	42										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		ACGTCATCCTCAGCTTCCTGT	0.303			NA											12	55					0	0	0.00499	0	0
ID3	3399	broad.mit.edu	37	1	23885762	23885762	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:23885762C>T	uc001bhh.3	-	1	561	c.156G>A	c.(154-156)CGG>CGA	p.R52R	ID3_uc001bhg.1_Silent_p.R52R	NM_002167	NP_002158	Q02535	ID3_HUMAN	inhibitor of DNA binding 3	52	Helix-loop-helix motif.				negative regulation of sequence-specific DNA binding transcription factor activity		transcription corepressor activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00314)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;8.83e-25)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;6.5e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		GTACCAGTTCCCGCAGGCGGG	0.642			NA											32	145					0	0	0.004289	0	0
TSSK3	81629	broad.mit.edu	37	1	32829545	32829545	+	Silent	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:32829545G>C	uc001bvf.2	+	2	936	c.495G>C	c.(493-495)CTG>CTC	p.L165L	uc001bve.1_5'Flank	NM_052841	NP_443073	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	165	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				ACCGGGAGCTGAGCCAGACCT	0.572			NA											54	102					0	0	0.01441	0	0
PIK3R3	8503	broad.mit.edu	37	1	46511639	46511639	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:46511639A>G	uc001cpb.3	-	9	1894	c.1138T>C	c.(1138-1140)TTC>CTC	p.F380L	PIK3R3_uc009vyb.2_Missense_Mutation_p.F321L|PIK3R3_uc009vyc.2_Missense_Mutation_p.F397L|PIK3R3_uc001cpc.3_Missense_Mutation_p.F380L|PIK3R3_uc010olw.1_Missense_Mutation_p.F426L|PIK3R3_uc010olv.1_Missense_Mutation_p.F170L	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	380	SH2 2.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					CGAATTAAGAATGCACCATCA	0.398			NA											30	132					0	0	0.013726	0	0
C1orf175	374977	broad.mit.edu	37	1	55175634	55175634	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:55175634G>A	uc010ooe.1	+	24	4070	c.3746G>A	c.(3745-3747)AGA>AAA	p.R1249K	C1orf175_uc001cxq.2_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.R767K|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.R450K	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1249						integral to membrane	binding				0						GATAACTTGAGACATGACCCA	0.517			NA											25	116					0	0	0.00632	0	0
SFRS11	9295	broad.mit.edu	37	1	70687463	70687463	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:70687463G>C	uc001des.2	+	2	268	c.144G>C	c.(142-144)CAG>CAC	p.Q48H	SFRS11_uc009wbi.2_Missense_Mutation_p.Q48H|SFRS11_uc009wbj.1_Missense_Mutation_p.Q48H|SFRS11_uc010oqo.1_Missense_Mutation_p.Q48H|SFRS11_uc001det.2_Missense_Mutation_p.Q48H|SFRS11_uc001deu.2_Missense_Mutation_p.Q48H	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	48	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						GCTCTGAGCAGATGCGGACTC	0.493			NA											100	109					0	0	0.01441	0	0
TNNI3K	51086	broad.mit.edu	37	1	74957833	74957833	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:74957833C>A	uc001dgf.1	+	23	2285	c.2234C>A	c.(2233-2235)TCT>TAT	p.S745Y	TNNI3K_uc001dge.1_Missense_Mutation_p.S846Y	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	745	Poly-Ser.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						CCTTCTTCTTCTTCTGATTGC	0.478			NA											63	281					1.31171e-36	1.65485e-36	0.01441	1	0
LHX8	431707	broad.mit.edu	37	1	75608822	75608822	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:75608822T>G	uc001dgo.2	+	6	1073	c.409T>G	c.(409-411)TCT>GCT	p.S137A	LHX8_uc001dgq.2_Missense_Mutation_p.S76A	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	137	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S137F(1)		ovary(3)	3						AACTCGCTGCTCTCGATGTGG	0.443			NA											17	61					0	0	0.010504	0	0
CLCA2	9635	broad.mit.edu	37	1	86900422	86900422	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:86900422G>T	uc001dlr.3	+	6	1128	c.966G>T	c.(964-966)ATG>ATT	p.M322I		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	322	VWFA.|Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CCAGCAAGATGGCAGAGGTAA	0.343	Melanoma(157;1000 1898 5363 5664 48018)|Ovarian(88;135 1366 2838 28875 34642)		NA											5	131					0.000602214	0.000620904	0.000602	1	0
CLCA4	22802	broad.mit.edu	37	1	87045236	87045236	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:87045236G>C	uc009wcs.2	+	13	2366	c.2322G>C	c.(2320-2322)TGG>TGC	p.W774C	CLCA4_uc009wct.2_Missense_Mutation_p.W537C|CLCA4_uc009wcu.2_Missense_Mutation_p.W594C	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	774						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTCTTACATGGACAGCACCAG	0.408			NA											47	74					0	0	0.01441	0	0
S1PR1	1901	broad.mit.edu	37	1	101705580	101705580	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:101705580G>T	uc001dud.2	+	2	1554	c.1040G>T	c.(1039-1041)GGC>GTC	p.G347V	S1PR1_uc009weg.2_Missense_Mutation_p.G347V	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	347	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						ATCATCGCCGGCATGGAATTC	0.552			NA											61	242					1.82294e-38	2.30957e-38	0.01441	1	0
COL11A1	1301	broad.mit.edu	37	1	103364245	103364245	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:103364245G>A	uc001dul.2	-	56	4543	c.4225C>T	c.(4225-4227)CTT>TTT	p.L1409F	COL11A1_uc001duk.2_Missense_Mutation_p.L605F|COL11A1_uc001dum.2_Missense_Mutation_p.L1421F|COL11A1_uc001dun.2_Missense_Mutation_p.L1370F|COL11A1_uc009weh.2_Missense_Mutation_p.L1293F	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1409	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATGCCCCGAAGACCTTCTGGA	0.448			NA											43	69					0	0	0.01441	0	0
RBM15	64783	broad.mit.edu	37	1	110882847	110882847	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:110882847G>A	uc001dzl.1	+	1	903	c.820G>A	c.(820-822)GGG>AGG	p.G274R	RBM15_uc001dzm.1_Missense_Mutation_p.G274R|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	274					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAGTGTGGTCGGGGCCTCTGT	0.597			NA	T	MKL1	acute megakaryocytic leukemia								54	178					0	0	0.01441	0	0
MAN1A2	10905	broad.mit.edu	37	1	117944871	117944871	+	Silent	SNP	A	A	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:117944871A>C	uc001ehd.1	+	2	1087	c.366A>C	c.(364-366)GCA>GCC	p.A122A	MAN1A2_uc009whg.1_Intron	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	122	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		TGGAAGAAGCAAAAGAAAAAT	0.373	Ovarian(33;199 881 8228 13687 31538)		NA											10	34					0	0	0.006214	0	0
FLG	2312	broad.mit.edu	37	1	152284211	152284211	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:152284211G>A	uc001ezu.1	-	3	3187	c.3151C>T	c.(3151-3153)CGC>TGC	p.R1051C	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1051	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTTGTCTGCGCGGAATGCCT	0.562			NA							Ichthyosis				338	489					0	0	0.01441	0	0
KPRP	448834	broad.mit.edu	37	1	152733114	152733114	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:152733114C>G	uc001fal.1	+	2	1108	c.1050C>G	c.(1048-1050)ATC>ATG	p.I350M		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	350	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCCCATCAGACGCCGCT	0.652			NA											35	100					0	0	0.004878	0	0
DCST1	149095	broad.mit.edu	37	1	155015885	155015885	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:155015885G>A	uc001fgn.1	+	10	1168	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	DCST1_uc010per.1_Missense_Mutation_p.E383K|DCST1_uc010pes.1_Missense_Mutation_p.E333K	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	358	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CGTGAGCACCGAGGTGCGGGA	0.667			NA											27	109					0	0	0.00632	0	0
PIGM	93183	broad.mit.edu	37	1	160001137	160001137	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:160001137C>G	uc001fuv.1	-	1	647	c.393G>C	c.(391-393)TGG>TGC	p.W131C		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	131	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGTTAAGAAGCCAAAAGACAC	0.562			NA											12	22					0	0	0.004007	0	0
FMO3	2328	broad.mit.edu	37	1	171083381	171083381	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:171083381A>C	uc001ghi.2	+	7	1173	c.1062A>C	c.(1060-1062)AAA>AAC	p.K354N	FMO3_uc001ghh.2_Missense_Mutation_p.K354N|FMO3_uc010pmb.1_Missense_Mutation_p.K334N|FMO3_uc010pmc.1_Missense_Mutation_p.K291N	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	354					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTTTATTTAAAGGAGTATTTC	0.443			NA											26	81					0	0	0.003954	0	0
TNN	63923	broad.mit.edu	37	1	175049473	175049473	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:175049473G>T	uc001gkl.1	+	4	1072	c.959G>T	c.(958-960)GGT>GTT	p.G320V	TNN_uc010pmx.1_Missense_Mutation_p.G320V	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	320	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GAGATTCTTGGTTTGCTGCCT	0.537			NA											39	136					2.40579e-17	2.79896e-17	0.00623	1	0
NFASC	23114	broad.mit.edu	37	1	204948557	204948557	+	Silent	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:204948557C>A	uc001hbj.2	+	19	2374	c.2046C>A	c.(2044-2046)CCC>CCA	p.P682P	NFASC_uc010pra.1_Silent_p.P678P|NFASC_uc001hbi.2_Silent_p.P678P|NFASC_uc010prb.1_Silent_p.P693P|NFASC_uc010prc.1_Silent_p.P249P|NFASC_uc001hbk.1_Silent_p.P488P|NFASC_uc001hbl.1_5'Flank	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	682	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCAAGTACCCCGGCAGCGTTA	0.572			NA											44	216					5.78141e-17	6.70017e-17	0.013114	1	0
EPRS	2058	broad.mit.edu	37	1	220156531	220156531	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:220156531C>T	uc001hly.1	-	22	3570	c.3300G>A	c.(3298-3300)GAG>GAA	p.E1100E		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1100	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	GCTCACTTACCTCTGGGGCAA	0.343			NA											46	54					0	0	0.013114	0	0
EPRS	2058	broad.mit.edu	37	1	220170591	220170591	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:220170591C>A	uc001hly.1	-	18	2545	c.2275G>T	c.(2275-2277)GTT>TTT	p.V759F	EPRS_uc010puf.1_Missense_Mutation_p.V510F|EPRS_uc001hlz.1_Missense_Mutation_p.V766F	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	759	WHEP-TRS 1.|Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TCTCCTTGAACAGCCACTCTA	0.388			NA											34	36					3.90053e-15	4.45136e-15	0.012213	1	0
TP53BP2	7159	broad.mit.edu	37	1	223971971	223971971	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:223971971G>C	uc010pvb.1	-	17	3501	c.3209C>G	c.(3208-3210)GCG>GGG	p.A1070G	TP53BP2_uc001hod.2_Missense_Mutation_p.A941G|TP53BP2_uc010puz.1_Missense_Mutation_p.A303G|TP53BP2_uc010pva.1_Missense_Mutation_p.A709G	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	1064	Mediates interaction with APC2.|SH3.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		ATCCCAAAGCGCATAAATGAC	0.403			NA											3	120					0	0	0.004672	0	0
URB2	9816	broad.mit.edu	37	1	229794951	229794952	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:229794951_229794952GC>AT	uc001hts.1	+	10	4618_4619	c.4482_4483GC>AT	c.(4480-4485)CAGCCG>CAATCG	p.P1495S	URB2_uc009xfd.1_Missense_Mutation_p.P1495S	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1495						nucleolus				central_nervous_system(2)|ovary(1)	3						CCTCGCTGCAGCCGGGAATGAG	0.505			NA											6	331					0	0	0.004672	0	0
PCNXL2	80003	broad.mit.edu	37	1	233134066	233134066	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:233134066T>C	uc001hvl.2	-	32	5957	c.5722A>G	c.(5722-5724)AGC>GGC	p.S1908G	PCNXL2_uc001hvk.1_Missense_Mutation_p.S560G|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1908						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TGTTCTGCGCTGCTCTCCTGG	0.632			NA											12	56					0	0	0.010729	0	0
NID1	4811	broad.mit.edu	37	1	236205495	236205495	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:236205495C>A	uc001hxo.2	-	4	952	c.850G>T	c.(850-852)GAA>TAA	p.E284*	NID1_uc009xgd.2_Nonsense_Mutation_p.E284*	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	284					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCCCCATCTTCAGTTCCGAGG	0.567			NA											101	381					1.09905e-38	1.39836e-38	0.01441	1	0
RYR2	6262	broad.mit.edu	37	1	237995884	237995884	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:237995884G>T	uc001hyl.1	+	105	14961	c.14841G>T	c.(14839-14841)AGG>AGT	p.R4947S	RYR2_uc010pyb.1_3'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4947					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCAAGAAAGGTGTTGGGAAT	0.388			NA											17	21					8.34094e-07	8.75067e-07	0.008871	1	0
CUBN	8029	broad.mit.edu	37	10	16982170	16982170	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:16982170G>A	uc001ioo.2	-	37	5461	c.5409C>T	c.(5407-5409)GCC>GCT	p.A1803A		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1803	CUB 12.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGTGACCCGTGGCATTTCCTT	0.438			NA											79	304					0	0	0.01441	0	0
NSUN6	221078	broad.mit.edu	37	10	18937479	18937479	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:18937479C>T	uc010qcp.1	-	2	589	c.171G>A	c.(169-171)GTG>GTA	p.V57V		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	57							methyltransferase activity|RNA binding			ovary(2)	2						AATGTGTATTCACTCTGACAG	0.338			NA											11	51					0	0	0.010729	0	0
MAPK8	5599	broad.mit.edu	37	10	49642948	49642948	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:49642948C>G	uc009xnz.2	+	12	1384	c.1160C>G	c.(1159-1161)TCT>TGT	p.S387C	MAPK8_uc001jgl.2_3'UTR|MAPK8_uc001jgm.2_Missense_Mutation_p.S387C|MAPK8_uc001jgo.2_3'UTR|MAPK8_uc009xoa.2_3'UTR|MAPK8_uc001jgn.2_Missense_Mutation_p.S387C|MAPK8_uc010qgk.1_3'UTR|MAPK8_uc001jgp.2_Missense_Mutation_p.S387C|MAPK8_uc001jgq.2_3'UTR	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	387					activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		ATCAATGGCTCTCAGCATCCA	0.483			NA											47	131					0	0	0.011902	0	0
HHEX	3087	broad.mit.edu	37	10	94452138	94452138	+	Silent	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:94452138C>G	uc001kid.2	+	2	438	c.375C>G	c.(373-375)CTC>CTG	p.L125L		NM_002729	NP_002720	Q03014	HHEX_HUMAN	hematopoietically expressed homeobox	125	Pro-rich.				anterior/posterior pattern formation|B cell differentiation|cell cycle|DNA conformation change|negative regulation of angiogenesis|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of vascular endothelial growth factor receptor signaling pathway|poly(A)+ mRNA export from nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|Wnt receptor signaling pathway	cytoplasm|nucleus|protein-DNA complex	DNA bending activity|eukaryotic initiation factor 4E binding|protein homodimerization activity|repressing transcription factor binding|sequence-specific DNA binding|TBP-class protein binding|transcription regulatory region DNA binding			ovary(1)	1						AACCTCTACTCTGGAGCCCCT	0.617			NA											64	84					0	0	0.01441	0	0
HHEX	3087	broad.mit.edu	37	10	94452163	94452163	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:94452163C>G	uc001kid.2	+	2	463	c.400C>G	c.(400-402)CTG>GTG	p.L134V		NM_002729	NP_002720	Q03014	HHEX_HUMAN	hematopoietically expressed homeobox	134					anterior/posterior pattern formation|B cell differentiation|cell cycle|DNA conformation change|negative regulation of angiogenesis|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of vascular endothelial growth factor receptor signaling pathway|poly(A)+ mRNA export from nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|Wnt receptor signaling pathway	cytoplasm|nucleus|protein-DNA complex	DNA bending activity|eukaryotic initiation factor 4E binding|protein homodimerization activity|repressing transcription factor binding|sequence-specific DNA binding|TBP-class protein binding|transcription regulatory region DNA binding			ovary(1)	1						GCAGAGGCCTCTGCATAAAAG	0.602			NA											65	80					0	0	0.01441	0	0
LGI1	9211	broad.mit.edu	37	10	95549856	95549856	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:95549856G>T	uc001kjc.3	+	5	768	c.432G>T	c.(430-432)TTG>TTT	p.L144F	LGI1_uc010qnv.1_Missense_Mutation_p.L96F|LGI1_uc001kjd.3_Missense_Mutation_p.L144F|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_RNA	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	144	LRR 3.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)				TTTTTTCCAGGAGCCTTGCAA	0.338			NA											9	33					2.17888e-05	2.26998e-05	0.006214	1	0
SORCS1	114815	broad.mit.edu	37	10	108434855	108434855	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:108434855A>C	uc001kym.2	-	14	1900	c.1892T>G	c.(1891-1893)TTT>TGT	p.F631C	SORCS1_uc001kyl.2_Missense_Mutation_p.F631C|SORCS1_uc009xxs.2_Missense_Mutation_p.F631C|SORCS1_uc001kyn.1_Missense_Mutation_p.F631C|SORCS1_uc001kyo.2_Missense_Mutation_p.F631C	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	631	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCCATCCACAAAAAGTGGAAT	0.398			NA											49	78					0	0	0.01441	0	0
KCNK18	338567	broad.mit.edu	37	10	118969302	118969302	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:118969302C>A	uc010qsr.1	+	3	647	c.647C>A	c.(646-648)ACA>AAA	p.T216K		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	216	Cytoplasmic (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		AAACTTGGCACATGTCCTTCA	0.527			NA											48	130					3.16986e-14	3.57656e-14	0.01441	1	0
PDZD8	118987	broad.mit.edu	37	10	119043731	119043731	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:119043731T>G	uc001lde.1	-	5	2712	c.2513A>C	c.(2512-2514)GAA>GCA	p.E838A		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	838					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		GTGTTTGTTTTCTGTTAAACC	0.383			NA											38	77					0	0	0.004289	0	0
CTBP2	1488	broad.mit.edu	37	10	126683170	126683170	+	Silent	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:126683170C>A	uc009yak.2	-	7	935	c.648G>T	c.(646-648)GGG>GGT	p.G216G	CTBP2_uc009yal.2_Silent_p.G216G|CTBP2_uc001lif.3_Silent_p.G216G|CTBP2_uc001lih.3_Silent_p.G216G|CTBP2_uc001lid.3_Silent_p.G284G|CTBP2_uc001lie.3_Silent_p.G756G	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	216					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		ACCGCTCGATCCCATCCTGCA	0.557			NA											21	136					3.01185e-09	3.25106e-09	0.003954	1	0
EBF3	253738	broad.mit.edu	37	10	131646712	131646712	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:131646712G>A	uc001lki.1	-	11	1104	c.1045C>T	c.(1045-1047)CAG>TAG	p.Q349*		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	358					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TGCAACCTCTGAAAGCCGTAA	0.468			NA											53	191					0	0	0.01441	0	0
GPR123	84435	broad.mit.edu	37	10	134896297	134896297	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr10:134896297G>A	uc001llw.2	+	7	1309	c.1309G>A	c.(1309-1311)GTG>ATG	p.V437M				Q86SQ6	GP123_HUMAN	RecName: Full=Probable G-protein coupled receptor 123;	Error:Variant_position_missing_in_Q86SQ6_after_alignment						integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GCCTGGATGCGTGTGCCAGGG	0.672			NA											8	28					0	0	0.004482	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444131	5444131	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:5444131C>A	uc010qzd.1	+	1	701	c.701C>A	c.(700-702)GCT>GAT	p.A234D	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCACCTGGGCTGAGCGACTC	0.483			NA											96	131					1.69331e-39	2.16368e-39	0.01441	1	0
OR56A3	390083	broad.mit.edu	37	11	5969183	5969183	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:5969183C>A	uc010qzt.1	+	1	607	c.607C>A	c.(607-609)CAA>AAA	p.Q203K		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCACCTTTACCAATTTGCTGG	0.478			NA											31	210					4.74835e-14	5.33744e-14	0.010818	1	0
USP47	55031	broad.mit.edu	37	11	11941942	11941942	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:11941942C>T	uc001mjq.1	+	11	1942	c.1179C>T	c.(1177-1179)TTC>TTT	p.F393F	USP47_uc001mjr.2_Silent_p.F305F|USP47_uc001mjs.2_Silent_p.F373F	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	393					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TGAAAAGATTCGATTTTGATT	0.358			NA											16	59					0	0	0.00499	0	0
LDHC	3948	broad.mit.edu	37	11	18456297	18456297	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:18456297G>C	uc001mon.3	+	5	541	c.429G>C	c.(427-429)TTG>TTC	p.L143F	LDHC_uc001mom.3_Missense_Mutation_p.L143F|LDHC_uc009yhp.2_Missense_Mutation_p.L143F|LDHC_uc001moo.3_Missense_Mutation_p.L27F|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_Missense_Mutation_p.L27F	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	143					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	TGGATATTTTGACATATATAG	0.308			NA											29	152					0	0	0.012213	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077532	19077532	+	Missense_Mutation	SNP	G	G	A	rs60756581	byFrequency	TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:19077532G>A	uc001mph.2	-	2	506	c.418C>T	c.(418-420)CGC>TGC	p.R140C		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	140	Cytoplasmic (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						CTGGGGCGGCGGCAGCGATAC	0.607	GBM(198;1966 2199 4849 37227 49954)		NA											22	91					0	0	0.00333	0	0
LUZP2	338645	broad.mit.edu	37	11	25004819	25004819	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:25004819G>T	uc001mqs.2	+	9	979	c.745G>T	c.(745-747)GAT>TAT	p.D249Y	LUZP2_uc009yif.2_Missense_Mutation_p.D163Y|LUZP2_uc009yig.2_Missense_Mutation_p.D207Y	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	249						extracellular region				ovary(1)|skin(1)	2						TAAGCTTCCAGATGCAGCGGC	0.428			NA											14	77					8.60227e-14	9.59731e-14	0.004007	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136580	40136580	+	Silent	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:40136580T>A	uc001mxa.1	-	2	3227	c.1263A>T	c.(1261-1263)ACA>ACT	p.T421T	LRRC4C_uc001mxc.1_Silent_p.T417T|LRRC4C_uc001mxd.1_Silent_p.T417T|LRRC4C_uc001mxb.1_Silent_p.T417T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	421	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGTACATGCCTGTATCTTGCA	0.438			NA											91	224					0	0	0.01441	0	0
OR4C3	256144	broad.mit.edu	37	11	48346987	48346987	+	Silent	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:48346987C>G	uc010rhv.1	+	1	495	c.495C>G	c.(493-495)CTC>CTG	p.L165L		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	138	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCAGGCATCTCTGTGCCATGC	0.537			NA											81	152					0	0	0.01441	0	0
OR4C11	219429	broad.mit.edu	37	11	55371624	55371624	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:55371624C>A	uc010rii.1	-	1	226	c.226G>T	c.(226-228)GCC>TCC	p.A76S		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AATCTAGGGGCTGTGGAAGTT	0.398			NA											36	20					6.90743e-12	7.53767e-12	0.003755	1	0
OR5L2	26338	broad.mit.edu	37	11	55595383	55595383	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:55595383C>A	uc001nhy.1	+	1	689	c.689C>A	c.(688-690)TCT>TAT	p.S230Y		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				AAGATACACTCTGCAGAGAGC	0.493			NA								HNSCC(27;0.073)			59	126					1.67886e-27	2.06576e-27	0.01441	1	0
TNKS1BP1	85456	broad.mit.edu	37	11	57080108	57080108	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:57080108A>G	uc001njr.2	-	4	2366	c.2054T>C	c.(2053-2055)CTG>CCG	p.L685P	TNKS1BP1_uc001njs.2_Missense_Mutation_p.L685P|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.L136P	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	685	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GAGGTCGTCCAGCCAGCGGGA	0.647			NA											47	78					0	0	0.01441	0	0
MS4A15	219995	broad.mit.edu	37	11	60543133	60543133	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:60543133C>T	uc009ynf.1	+	7	888	c.668C>T	c.(667-669)GCA>GTA	p.A223V	MS4A15_uc001npx.2_Missense_Mutation_p.A130V|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Missense_Mutation_p.A182V	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	223						integral to membrane	receptor activity			lung(1)	1						CCCAGCCCGGCAGCCTCTGCG	0.587			NA									OREG0020991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	204					0	0	0.01441	0	0
PLCB3	5331	broad.mit.edu	37	11	64029532	64029532	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:64029532C>T	uc001nzb.2	+	17	2022	c.2022C>T	c.(2020-2022)CTC>CTT	p.L674L	PLCB3_uc009ypg.1_Silent_p.L674L|PLCB3_uc009yph.1_Silent_p.L607L|PLCB3_uc009ypi.2_Silent_p.L674L	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	674	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						TTGTTGCGCTCAACTTCCAGA	0.607			NA											37	88					0	0	0.006999	0	0
C11orf2	738	broad.mit.edu	37	11	64875899	64875899	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:64875899C>T	uc001ocr.1	+	5	996	c.956C>T	c.(955-957)GCG>GTG	p.A319V	C11orf2_uc001ocs.1_Missense_Mutation_p.A195V	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	319					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						TGCCAGGTGGCGGCGGCCTAC	0.697			NA											3	47					0	0	0.009096	0	0
SPDYC	387778	broad.mit.edu	37	11	64940248	64940248	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:64940248C>T	uc010rnz.1	+	6	610	c.610C>T	c.(610-612)CGC>TGC	p.R204C		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	204					cell cycle	nucleus	protein kinase binding				0						GGTCCCTGTTCGCCTTCCCCG	0.652			NA											54	87					0	0	0.01441	0	0
LTBP3	4054	broad.mit.edu	37	11	65318931	65318931	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:65318931C>G	uc001oej.2	-	10	1832	c.1563G>C	c.(1561-1563)GAG>GAC	p.E521D	LTBP3_uc001oeh.2_5'Flank|LTBP3_uc010roi.1_Missense_Mutation_p.E404D|LTBP3_uc001oei.2_Missense_Mutation_p.E521D|LTBP3_uc010roj.1_Missense_Mutation_p.E222D|LTBP3_uc010rok.1_Missense_Mutation_p.E432D	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	521						extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						GCACTGACCTCTCCTCACTCA	0.637			NA											25	79					0	0	0.005443	0	0
GPR152	390212	broad.mit.edu	37	11	67219321	67219321	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:67219321G>T	uc001olm.2	-	1	880	c.875C>A	c.(874-876)CCC>CAC	p.P292H	uc009yrw.1_5'Flank|CABP4_uc001oln.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	292	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GCAGAGGAAGGGGCTGAGGCA	0.652	Pancreas(102;800 1581 2723 7382 33622)		NA											27	88					9.58827e-17	1.10691e-16	0.01441	1	0
LRP5	4041	broad.mit.edu	37	11	68115636	68115636	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:68115636A>G	uc001ont.2	+	2	488	c.413A>G	c.(412-414)AAT>AGT	p.N138S	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	138	Beta-propeller 1.|LDL-receptor class B 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GCCAACCTCAATGGCACATCC	0.647			NA											112	190					0	0	0.01441	0	0
C11orf30	56946	broad.mit.edu	37	11	76227233	76227233	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:76227233C>T	uc001oxl.2	+	11	1704	c.1561C>T	c.(1561-1563)CGG>TGG	p.R521W	C11orf30_uc001oxm.2_Missense_Mutation_p.R437W|C11orf30_uc010rsb.1_Missense_Mutation_p.R536W|C11orf30_uc010rsc.1_Missense_Mutation_p.R536W|C11orf30_uc001oxn.2_Missense_Mutation_p.R522W|C11orf30_uc010rsd.1_Missense_Mutation_p.R535W	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	521	Thr-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						ATCCATTGGTCGGATGGCTGC	0.473			NA											37	128					0	0	0.004878	0	0
MYO7A	4647	broad.mit.edu	37	11	76871264	76871264	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:76871264G>C	uc001oyb.2	+	11	1408	c.1136G>C	c.(1135-1137)GGG>GCG	p.G379A	MYO7A_uc010rsl.1_Missense_Mutation_p.G379A|MYO7A_uc010rsm.1_Missense_Mutation_p.G368A|MYO7A_uc001oyc.2_Missense_Mutation_p.G379A	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	379	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						ATCACCCGCGGGGAGACGGTG	0.667			NA											5	4					0	0	0.000602	0	0
ODZ4	26011	broad.mit.edu	37	11	78399268	78399268	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:78399268G>A	uc001ozl.3	-	29	5554	c.5091C>T	c.(5089-5091)TAC>TAT	p.Y1697Y	ODZ4_uc009yvb.1_Silent_p.Y281Y	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1697	YD 4.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CAAAGCTGTCGTACCTGGAAA	0.502			NA											108	225					0	0	0.01441	0	0
CEP57	9702	broad.mit.edu	37	11	95546154	95546154	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:95546154G>C	uc001pfp.1	+	3	482	c.261G>C	c.(259-261)AGG>AGC	p.R87S	CEP57_uc001pfo.1_Missense_Mutation_p.R87S|CEP57_uc010ruh.1_Missense_Mutation_p.R78S|CEP57_uc010rui.1_Missense_Mutation_p.R87S|CEP57_uc009ywn.1_5'UTR|CEP57_uc001pfq.1_Missense_Mutation_p.R87S|CEP57_uc001pfr.1_5'UTR	NM_014679	NP_055494	Q86XR8	CEP57_HUMAN	translokin	87	Potential.|centrosome localization domain (CLD) (By similarity).				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AACTTGAGAGGATTCAGGCAG	0.368			NA							Mosaic_Variegated_Aneuploidy_Syndrome				26	124					0	0	0.00333	0	0
EXPH5	23086	broad.mit.edu	37	11	108380461	108380461	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:108380461C>T	uc001pkk.2	-	6	5884	c.5773G>A	c.(5773-5775)GAT>AAT	p.D1925N	EXPH5_uc010rvy.1_Missense_Mutation_p.D1737N|EXPH5_uc010rvz.1_Missense_Mutation_p.D1769N|EXPH5_uc010rwa.1_Missense_Mutation_p.D1849N	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1925					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTCCTCAAATCATCTTTTAGG	0.408			NA											47	64					0	0	0.010771	0	0
DRD2	1813	broad.mit.edu	37	11	113286252	113286252	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:113286252G>T	uc001pnz.2	-	4	935	c.614C>A	c.(613-615)ACC>AAC	p.T205N	DRD2_uc010rwv.1_Missense_Mutation_p.T204N|DRD2_uc001poa.3_Missense_Mutation_p.T205N|DRD2_uc001pob.3_Missense_Mutation_p.T205N|DRD2_uc009yyr.1_Missense_Mutation_p.T205N	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	205	Helical; Name=5; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GACCAGCAGGGTGACAATGAA	0.592			NA											72	125					1.79293e-35	2.24304e-35	0.01441	1	0
DDX6	1656	broad.mit.edu	37	11	118635968	118635968	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr11:118635968T>A	uc001pub.2	-	6	956	c.595A>T	c.(595-597)ACC>TCC	p.T199S	DDX6_uc001puc.2_Missense_Mutation_p.T199S	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	199	Helicase ATP-binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		CCTCCTGTGGTTGCCATCACT	0.423			NA	T	IGH@	B-NHL								189	359					0	0	0.01441	0	0
FOXM1	2305	broad.mit.edu	37	12	2977850	2977850	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:2977850A>T	uc001qlf.2	-	4	990	c.725T>A	c.(724-726)ATG>AAG	p.M242K	FOXM1_uc001qle.2_Missense_Mutation_p.M242K|FOXM1_uc001qlg.2_Missense_Mutation_p.M242K|FOXM1_uc009zea.2_Missense_Mutation_p.M241K|FOXM1_uc009zeb.2_Missense_Mutation_p.M241K	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	242	Fork-head.				cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TATCATGGCCATGTAAGAGTA	0.498			NA											95	250					0	0	0.01441	0	0
PARP11	57097	broad.mit.edu	37	12	3938098	3938098	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:3938098G>A	uc001qmk.1	-	2	280	c.225C>T	c.(223-225)TTC>TTT	p.F75F	PARP11_uc001qml.2_Silent_p.F82F|PARP11_uc009zef.2_RNA|PARP11_uc001qmm.2_Intron|PARP11_uc001qmn.2_Intron	NM_020367	NP_065100	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	75	WWE.						NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			TCTTGTAGCTGAATTTGGAAG	0.358			NA											11	80					0	0	0.008291	0	0
ABCD2	225	broad.mit.edu	37	12	40013068	40013068	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:40013068C>G	uc001rmb.2	-	1	776	c.350G>C	c.(349-351)AGA>ACA	p.R117T		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	117	ABC transmembrane type-1.|Interaction with PEX19.|Helical; (Potential).				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						AAGAAAGGTTCTTGAGATTAG	0.413			NA											69	79					0	0	0.01441	0	0
KRT74	121391	broad.mit.edu	37	12	52967174	52967174	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:52967174C>T	uc001sap.1	-	1	436	c.388G>A	c.(388-390)GAC>AAC	p.D130N		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	130	Head.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		ATCTCAGGGTCCAGCTCCACG	0.602			NA											38	231					0	0	0.00874	0	0
OR6C70	390327	broad.mit.edu	37	12	55863582	55863582	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:55863582G>T	uc010spn.1	-	1	341	c.341C>A	c.(340-342)GCT>GAT	p.A114D		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGACAGAGCAGCTAGAAGGAA	0.393			NA											30	45					2.4375e-19	2.89211e-19	0.007291	1	0
BAZ2A	11176	broad.mit.edu	37	12	56999683	56999683	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:56999683C>T	uc001slq.1	-	13	2624	c.2430G>A	c.(2428-2430)CGG>CGA	p.R810R	BAZ2A_uc001slp.1_Silent_p.R808R|BAZ2A_uc009zov.1_5'Flank|BAZ2A_uc009zow.1_Silent_p.R778R	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	810					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						GCTGCCTCTGCCGTTCCTCCA	0.443			NA											8	15					0	0	0.006214	0	0
SRGAP1	57522	broad.mit.edu	37	12	64521497	64521497	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:64521497T>A	uc010ssp.1	+	20	2589	c.2533T>A	c.(2533-2535)TTA>ATA	p.L845I	SRGAP1_uc001srv.2_Missense_Mutation_p.L782I	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	845					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		TGACGGCTATTTAGCCAGGTA	0.597			NA											21	117					0	0	0.010504	0	0
SLC6A15	55117	broad.mit.edu	37	12	85266387	85266387	+	Silent	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:85266387T>A	uc001szv.2	-	8	1789	c.1296A>T	c.(1294-1296)CTA>CTT	p.L432L	SLC6A15_uc010sul.1_Silent_p.L325L|SLC6A15_uc001szw.1_Silent_p.L140L	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	432	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						TAACTTTATTTAGCTCTTCTT	0.328			NA											9	60					0	0	0.004482	0	0
EID3	493861	broad.mit.edu	37	12	104698247	104698247	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:104698247C>A	uc001tkw.2	+	1	699	c.535C>A	c.(535-537)CGT>AGT	p.R179S	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						CAAGCTAGAACGTTCTGCACC	0.428			NA											39	239					1.67305e-13	1.85963e-13	0.00623	1	0
RASAL1	8437	broad.mit.edu	37	12	113559391	113559391	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:113559391C>G	uc001tum.1	-	6	644	c.351G>C	c.(349-351)CAG>CAC	p.Q117H	RASAL1_uc010syp.1_Missense_Mutation_p.Q117H|RASAL1_uc001tul.2_Missense_Mutation_p.Q117H|RASAL1_uc001tun.1_Missense_Mutation_p.Q117H|RASAL1_uc010syq.1_Missense_Mutation_p.Q117H|RASAL1_uc001tuo.3_Missense_Mutation_p.Q117H|RASAL1_uc010syr.1_Missense_Mutation_p.Q117H	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	117					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						AGATCTCACCCTGCACTTCTG	0.493			NA											99	105					0	0	0.01441	0	0
FBXW8	26259	broad.mit.edu	37	12	117426577	117426577	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:117426577T>G	uc001twg.1	+	7	1224	c.1142T>G	c.(1141-1143)CTT>CGT	p.L381R	FBXW8_uc001twf.1_Missense_Mutation_p.L315R|FBXW8_uc009zwp.1_RNA	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8 isoform	381							protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		AGAACCCTCCTTTACGCCCAC	0.547			NA											8	403					0	0	0.00308	0	0
VPS33A	65082	broad.mit.edu	37	12	122748723	122748723	+	Silent	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:122748723T>A	uc001ucd.2	-	2	239	c.126A>T	c.(124-126)CTA>CTT	p.L42L	VPS33A_uc001ucc.2_RNA|VPS33A_uc001uce.2_Silent_p.L42L	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	42					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AGGGTCCAGTTAGGTATTCAT	0.343			NA											49	208					0	0	0.01441	0	0
POLE	5426	broad.mit.edu	37	12	133219516	133219516	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:133219516T>G	uc001uks.1	-	36	4662	c.4618A>C	c.(4618-4620)AAG>CAG	p.K1540Q	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.K344Q|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1540					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGGCCCACCTTCTCCAGGAGG	0.627			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					68	69					0	0	0.01441	0	0
ZMYM2	7750	broad.mit.edu	37	13	20608525	20608525	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr13:20608525G>C	uc001umr.2	+	12	2398	c.2100G>C	c.(2098-2100)AAG>AAC	p.K700N	ZMYM2_uc001ums.2_Missense_Mutation_p.K700N|ZMYM2_uc001umt.2_Missense_Mutation_p.K700N|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_Missense_Mutation_p.K80N|ZMYM2_uc001umw.2_Missense_Mutation_p.K153N	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	700					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CTGGCGTTAAGAGACCTTTCT	0.343			NA											35	84					0	0	0.004878	0	0
LATS2	26524	broad.mit.edu	37	13	21557918	21557918	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr13:21557918G>C	uc009zzs.2	-	5	2292	c.1927C>G	c.(1927-1929)CAG>GAG	p.Q643E	LATS2_uc001unr.3_Missense_Mutation_p.Q643E	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	643					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		TTCCGCATCTGCTCCTGCTCA	0.458			NA											17	64					0	0	0.007413	0	0
FGF9	2254	broad.mit.edu	37	13	22255205	22255205	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr13:22255205C>A	uc001uog.2	+	2	1139	c.302C>A	c.(301-303)GCA>GAA	p.A101E		NM_002010	NP_002001	P31371	FGF9_HUMAN	fibroblast growth factor 9 precursor	101					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|male gonad development|positive regulation of cell division	extracellular space	growth factor activity|heparin binding				0		all_cancers(29;1.23e-20)|all_epithelial(30;9.83e-19)|all_lung(29;9.64e-17)|Lung SC(185;0.0262)|Breast(139;0.106)		all cancers(112;3.92e-05)|Epithelial(112;0.000166)|OV - Ovarian serous cystadenocarcinoma(117;0.00314)|Lung(94;0.163)		ATCAGTATAGCAGTGGGCCTG	0.517	Melanoma(195;1939 2127 12623 13963 52730)		NA											27	22					2.61193e-14	2.95821e-14	0.009535	1	0
PCDH17	27253	broad.mit.edu	37	13	58208543	58208543	+	Silent	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr13:58208543G>T	uc001vhq.1	+	1	2755	c.1863G>T	c.(1861-1863)GGG>GGT	p.G621G	PCDH17_uc010aec.1_Silent_p.G621G	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	621	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCGAGAGCGGGCGTCTCACCT	0.657	Melanoma(72;952 1291 1619 12849 33676)		NA											10	162					4.3838e-07	4.64807e-07	0.001855	1	0
MYCBP2	23077	broad.mit.edu	37	13	77847609	77847609	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr13:77847609G>C	uc001vkf.2	-	6	920	c.829C>G	c.(829-831)CAG>GAG	p.Q277E	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGAAATACCTGAATAGTTTGG	0.398			NA											14	45					0	0	0.00499	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328774	88328774	+	Silent	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr13:88328774G>T	uc001vln.2	+	2	1350	c.1131G>T	c.(1129-1131)GCG>GCT	p.A377A	SLITRK5_uc010tic.1_Silent_p.A136A	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	377	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTCCCACCGCGTGCTCTTGCA	0.577			NA											61	84					3.74213e-36	4.70124e-36	0.01441	1	0
GPC5	2262	broad.mit.edu	37	13	93518680	93518680	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr13:93518680C>T	uc010tif.1	+	8	2073	c.1707C>T	c.(1705-1707)CCC>CCT	p.P569P		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	569						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGTTACTTCCCGGGATTTGGT	0.433			NA											24	88					0	0	0.00278	0	0
TEP1	7011	broad.mit.edu	37	14	20846397	20846397	+	Splice_Site	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr14:20846397T>A	uc001vxe.2	-	39	5549	c.5509_splice	c.e39-1	p.D1837_splice	TEP1_uc010ahk.2_Splice_Site_p.D1180_splice|TEP1_uc010tlf.1_Splice_Site|TEP1_uc010tlg.1_Splice_Site_p.D1729_splice|TEP1_uc010tlh.1_Splice_Site_p.D175_splice	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1						telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCCCAGGTCCTACACAGGGAG	0.582			NA											60	34					0	0	0.01441	0	0
HNRNPC	3183	broad.mit.edu	37	14	21699132	21699132	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr14:21699132G>A	uc001vzy.2	-	4	585	c.341C>T	c.(340-342)CCG>CTG	p.P114L	HNRNPC_uc001vzw.2_Intron|HNRNPC_uc001wad.2_Intron|HNRNPC_uc001vzx.2_Intron|HNRNPC_uc001vzz.2_Intron|HNRNPC_uc001waa.2_Missense_Mutation_p.P114L|HNRNPC_uc010ail.2_Missense_Mutation_p.P114L|HNRNPC_uc010tlq.1_RNA|HNRNPC_uc001wab.2_Intron|HNRNPC_uc001wac.2_Intron|HNRNPC_uc010tlr.1_5'Flank|HNRNPC_uc001waf.2_Intron|HNRNPC_uc001wae.2_Intron	NM_031314	NP_112604	P07910	HNRPC_HUMAN	heterogeneous nuclear ribonucleoprotein C	114						catalytic step 2 spliceosome|nucleoplasm	identical protein binding|nucleotide binding|RNA binding				0	all_cancers(95;0.00176)		Epithelial(56;1.08e-06)|all cancers(55;8.95e-06)	GBM - Glioblastoma multiforme(265;0.00783)		TAGAGGGGACGGAGAAGGGTG	0.478	NSCLC(108;607 2244 12726 38757)		NA											19	168					0	0	0.007413	0	0
MDGA2	161357	broad.mit.edu	37	14	47566113	47566113	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr14:47566113A>T	uc001wwj.3	-	6	1128	c.932T>A	c.(931-933)ATT>AAT	p.I311N	MDGA2_uc001wwi.3_Missense_Mutation_p.I82N|MDGA2_uc010ani.2_Translation_Start_Site	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	311	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						ATTATTGGCAATGCAGCTGTA	0.433			NA											14	404					0	0	0.00245	0	0
SAV1	60485	broad.mit.edu	37	14	51132088	51132088	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr14:51132088G>C	uc001wyg.1	-	3	505	c.344C>G	c.(343-345)TCA>TGA	p.S115*	SAV1_uc001wyh.1_Nonsense_Mutation_p.S115*	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	115					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					CGTTACAAATGACTGAGAAGA	0.393			NA											3	84					0	0	0.000602	0	0
C14orf101	54916	broad.mit.edu	37	14	57099793	57099793	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr14:57099793C>T	uc001xcm.2	+	13	1750	c.1628C>T	c.(1627-1629)TCT>TTT	p.S543F	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Missense_Mutation_p.S76F|C14orf101_uc001xco.2_Missense_Mutation_p.S76F	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	543						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		CCATGGGGGTCTTGTGACAAA	0.368			NA											19	47					0	0	0.010504	0	0
C14orf159	80017	broad.mit.edu	37	14	91691111	91691111	+	Silent	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr14:91691111G>T	uc001xzb.2	+	16	2553	c.1785G>T	c.(1783-1785)CTG>CTT	p.L595L	C14orf159_uc001xyx.2_Silent_p.L543L|C14orf159_uc001xyw.2_Silent_p.L600L|C14orf159_uc001xzc.2_Silent_p.L595L|C14orf159_uc001xza.2_Silent_p.L600L|C14orf159_uc001xyv.2_Silent_p.L560L|C14orf159_uc001xyz.2_Silent_p.L471L|C14orf159_uc001xze.2_Silent_p.L595L	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	595						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		TGGATGGGCTGCCCTTCCACA	0.572			NA											39	18					8.16277e-20	9.72378e-20	0.006999	1	0
RIN3	79890	broad.mit.edu	37	14	93118640	93118640	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr14:93118640C>T	uc001yap.2	+	6	1398	c.1246C>T	c.(1246-1248)CAA>TAA	p.Q416*	RIN3_uc010auk.2_Nonsense_Mutation_p.Q78*|RIN3_uc001yaq.2_Nonsense_Mutation_p.Q341*|RIN3_uc001yar.1_Nonsense_Mutation_p.Q78*|RIN3_uc001yas.1_Nonsense_Mutation_p.Q78*	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	416	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CCTGCCTCCCCAAGGGACCTC	0.657			NA											23	68					0	0	0.003954	0	0
OCA2	4948	broad.mit.edu	37	15	28202874	28202874	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:28202874C>A	uc001zbh.3	-	16	1754	c.1644G>T	c.(1642-1644)AAG>AAT	p.K548N	OCA2_uc010ayv.2_Missense_Mutation_p.K524N	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	548	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GAATCTCGTGCTTCAGTTCTG	0.612			NA							Oculocutaneous_Albinism				34	56					1.414e-09	1.53183e-09	0.003755	1	0
OCA2	4948	broad.mit.edu	37	15	28211923	28211923	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:28211923A>T	uc001zbh.3	-	15	1659	c.1549T>A	c.(1549-1551)TGC>AGC	p.C517S	OCA2_uc010ayv.2_Missense_Mutation_p.C493S	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	517	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGAACAAGGCAAATCCCAATG	0.418			NA							Oculocutaneous_Albinism				20	47					0	0	0.012319	0	0
RYR3	6263	broad.mit.edu	37	15	33991970	33991970	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:33991970G>A	uc001zhi.2	+	41	6385	c.6315G>A	c.(6313-6315)CGG>CGA	p.R2105R	RYR3_uc010bar.2_Silent_p.R2105R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2105	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAATTAGCCGGCAAAATCAGA	0.433			NA											3	58					0	0	0.004672	0	0
SLC12A6	9990	broad.mit.edu	37	15	34551102	34551102	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:34551102C>T	uc001zhw.2	-	4	619	c.455G>A	c.(454-456)CGC>CAC	p.R152H	SLC12A6_uc001zhv.2_Missense_Mutation_p.R101H|SLC12A6_uc001zhx.2_Missense_Mutation_p.R137H|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.R93H|SLC12A6_uc001zib.2_Missense_Mutation_p.R143H|SLC12A6_uc001zic.2_Missense_Mutation_p.R152H|SLC12A6_uc010bau.2_Missense_Mutation_p.R152H|SLC12A6_uc001zid.2_Missense_Mutation_p.R93H|SLC12A6_uc001zhu.2_Missense_Mutation_p.R13H	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	152	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	ATTGGCCATGCGGTTGAGGAG	0.458			NA											4	220					0	0	0.009096	0	0
DLL4	54567	broad.mit.edu	37	15	41222861	41222861	+	Silent	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:41222861A>T	uc001zng.1	+	3	695	c.375A>T	c.(373-375)CCA>CCT	p.P125P		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	125	Extracellular (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGCACGCGCCAGGAGACGACC	0.652			NA									OREG0023070	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	25					0	0	0.013537	0	0
CAPN3	825	broad.mit.edu	37	15	42702827	42702827	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:42702827C>G	uc001zpn.1	+	21	2532	c.2226C>G	c.(2224-2226)ATC>ATG	p.I742M	CAPN3_uc001zpk.1_Missense_Mutation_p.I509M|CAPN3_uc001zpl.1_Missense_Mutation_p.I649M|CAPN3_uc010udf.1_Missense_Mutation_p.I655M|CAPN3_uc010udg.1_Missense_Mutation_p.I607M|CAPN3_uc001zpo.1_Missense_Mutation_p.I736M|CAPN3_uc001zpp.1_Missense_Mutation_p.I650M|CAPN3_uc001zpq.1_Missense_Mutation_p.I230M|CAPN3_uc010bcv.1_Missense_Mutation_p.I77M|CAPN3_uc001zpr.1_Missense_Mutation_p.I77M|CAPN3_uc001zps.1_Missense_Mutation_p.I77M|CAPN3_uc001zpt.1_Missense_Mutation_p.I77M	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	742	EF-hand 3.|2 (Probable).|Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CCGGCACCATCAACAGCTACG	0.512			NA											15	30					0	0	0.00245	0	0
CEP152	22995	broad.mit.edu	37	15	49048414	49048414	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:49048414G>A	uc001zwy.2	-	20	3065	c.3031C>T	c.(3031-3033)CAG>TAG	p.Q1011*	CEP152_uc001zwz.2_Nonsense_Mutation_p.Q1011*|CEP152_uc001zxa.1_Nonsense_Mutation_p.Q918*	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1011					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		GTCTCCTTCTGAAGAAGTAGT	0.393			NA											35	62					0	0	0.003271	0	0
UNC13C	440279	broad.mit.edu	37	15	54305729	54305729	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:54305729G>A	uc002ack.2	+	1	629	c.629G>A	c.(628-630)AGA>AAA	p.R210K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	210					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGGGGAATAAGAAGTAAGTCT	0.438			NA											39	150					0	0	0.006999	0	0
PRTG	283659	broad.mit.edu	37	15	55965800	55965800	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:55965800G>T	uc002adg.2	-	10	1669	c.1621C>A	c.(1621-1623)CCA>ACA	p.P541T	PRTG_uc002adh.2_Missense_Mutation_p.P43T	NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	541	Fibronectin type-III 2.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TATTTGGCTGGGATTGGCAGC	0.498			NA											60	130					6.0678e-26	7.43554e-26	0.01441	1	0
VPS13C	54832	broad.mit.edu	37	15	62254661	62254661	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:62254661T>A	uc002agz.2	-	34	3586	c.3512A>T	c.(3511-3513)TAT>TTT	p.Y1171F	VPS13C_uc002aha.2_Missense_Mutation_p.Y1128F|VPS13C_uc002ahb.1_Missense_Mutation_p.Y1171F|VPS13C_uc002ahc.1_Missense_Mutation_p.Y1128F	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1171					protein localization					ovary(2)	2						CATGTCAGTATACAAATCCCC	0.368			NA											85	169					0	0	0.01441	0	0
HERC1	8925	broad.mit.edu	37	15	64045267	64045267	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:64045267C>A	uc002amp.2	-	8	1940	c.1792G>T	c.(1792-1794)GAT>TAT	p.D598Y	HERC1_uc010uil.1_Intron|HERC1_uc010bgt.1_Missense_Mutation_p.D598Y	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	598	RCC1 5.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CTGTTGGTATCACCATGACCA	0.343			NA											10	53					7.48243e-07	7.90546e-07	0.006214	1	0
CILP	8483	broad.mit.edu	37	15	65489559	65489559	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:65489559C>T	uc002aon.2	-	9	3246	c.3065G>A	c.(3064-3066)CGC>CAC	p.R1022H		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	1022					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CACCAGGGTGCGGTCCACACG	0.592			NA											5	168					0	0	0.000602	0	0
LBXCOR1	390598	broad.mit.edu	37	15	68119495	68119495	+	Silent	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:68119495C>G	uc002aqy.1	+	3	1197	c.1197C>G	c.(1195-1197)GCC>GCG	p.A399A		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	443					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						gcccgggagccagccacttgc	0.358			NA											2	1					0	0	0.004672	0	0
RPP25	54913	broad.mit.edu	37	15	75248342	75248342	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:75248342C>T	uc002azj.1	-	1	1434	c.583G>A	c.(583-585)GAG>AAG	p.E195K		NM_017793	NP_060263	Q9BUL9	RPP25_HUMAN	ribonuclease P 25kDa subunit	195					tRNA processing	nucleus	protein binding|ribonuclease P activity|RNA binding				0						GTCTGATCCTCGTCCGCAACC	0.662			NA											9	50					0	0	0.006214	0	0
TSPAN3	10099	broad.mit.edu	37	15	77348204	77348204	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:77348204A>T	uc002bcj.2	-	3	474	c.257T>A	c.(256-258)TTT>TAT	p.F86Y	TSPAN3_uc002bck.2_Intron|TSPAN3_uc010ump.1_Missense_Mutation_p.F22Y|TSPAN3_uc010bkx.2_Intron	NM_005724	NP_005715	O60637	TSN3_HUMAN	transmembrane 4 superfamily member 8 isoform 1	86	Helical; (Potential).					integral to membrane					0				all cancers(203;1.14e-19)		GATGATGACAAACTGTAAGAA	0.289			NA											41	86					0	0	0.007835	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79066595	79066595	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:79066595C>T	uc002bej.3	-	13	2135	c.1924G>A	c.(1924-1926)GAG>AAG	p.E642K	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Missense_Mutation_p.E642K	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	642	Cys-rich.			E -> K (in Ref. 1; AAD56358).	proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CGCAGCTTCTCGGCAAAGTAC	0.627			NA											3	20					0	0	0.009096	0	0
KLHL25	64410	broad.mit.edu	37	15	86311732	86311732	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr15:86311732G>T	uc002bly.2	-	2	1513	c.1310C>A	c.(1309-1311)GCC>GAC	p.A437D		NM_022480	NP_071925	Q9H0H3	ENC2_HUMAN	BTB/POZ KELCH domain protein	437	Kelch 3.					cytoplasm				ovary(2)	2						CACCACTGCGGCATTGCTGAC	0.587			NA											32	130					5.60225e-13	6.20397e-13	0.009535	1	0
KIAA0430	9665	broad.mit.edu	37	16	15705448	15705448	+	Splice_Site	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:15705448C>A	uc002ddr.2	-	18	3810	c.3617_splice	c.e18+1	p.W1206_splice	KIAA0430_uc002ddq.2_Splice_Site_p.W1040_splice|KIAA0430_uc010uzv.1_Splice_Site_p.W1202_splice|KIAA0430_uc010uzw.1_Splice_Site_p.W1205_splice	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1							peroxisome	nucleotide binding|RNA binding				0						CATCAACTCACCAGTGATAAG	0.368			NA											31	52					7.16026e-08	7.64613e-08	0.012213	1	0
ITPRIPL2	162073	broad.mit.edu	37	16	19126881	19126881	+	Silent	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:19126881A>T	uc002dfu.3	+	1	1628	c.1098A>T	c.(1096-1098)GCA>GCT	p.A366A	ITPRIPL2_uc002dft.2_Silent_p.A62A	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	366	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						AGGAACGGGCAGCTCCAGGTG	0.667			NA											30	112					0	0	0.009535	0	0
SH2B1	25970	broad.mit.edu	37	16	28878061	28878061	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:28878061G>C	uc002dri.2	+	4	1085	c.646G>C	c.(646-648)GAT>CAT	p.D216H	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.D216H|SH2B1_uc002drk.2_Missense_Mutation_p.D216H|SH2B1_uc002drl.2_Missense_Mutation_p.D216H|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.D216H|SH2B1_uc002drm.2_Missense_Mutation_p.D216H	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	216	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Required for NGF signaling (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						ACTGGTCAGTGATGGAACGTC	0.622			NA											37	49					0	0	0.004878	0	0
CES4	51716	broad.mit.edu	37	16	55806422	55806422	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:55806422T>A	uc002eik.2	+	5	724	c.273T>A	c.(271-273)AGT>AGA	p.S91R	CES4_uc010cce.2_Missense_Mutation_p.S91R	NR_003276				RecName: Full=Inactive carboxylesterase 4; AltName: Full=Placental carboxylesterase 3;          Short=PCE-3; Flags: Precursor;												0						GAGGAGAAAGTGTCTCTGTTC	0.557			NA											6	25					0	0	0.001168	0	0
CES1	1066	broad.mit.edu	37	16	55866969	55866969	+	Translation_Start_Site	SNP	G	G	A	rs28515828	byFrequency	TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:55866969G>A	uc002eim.2	-	1	107	c.-1C>T	c.(-3-1)CACGA>CATGA		CES1_uc002eil.2_Translation_Start_Site|CES1_uc002ein.2_Translation_Start_Site	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor						response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	GAGCCACATCGTGGAAGGGCG	0.602	NSCLC(162;1801 2756 42904 52896)		NA											20	83					0	0	0.00632	0	0
TEPP	374739	broad.mit.edu	37	16	58011792	58011792	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:58011792G>A	uc002emw.3	+	2	274	c.237G>A	c.(235-237)CTG>CTA	p.L79L	TEPP_uc002emv.3_Silent_p.L79L	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	79						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						CGGCCATCCTGCTTCCCATGG	0.657			NA											132	208					0	0	0.01441	0	0
KCTD19	146212	broad.mit.edu	37	16	67338379	67338379	+	Silent	SNP	T	T	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:67338379T>C	uc002esu.2	-	3	447	c.396A>G	c.(394-396)ACA>ACG	p.T132T	KCTD19_uc002est.2_5'UTR|KCTD19_uc010vjj.1_5'UTR	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	132						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TACACTTCCATGTACGCCAGT	0.478			NA											91	143					0	0	0.01441	0	0
CENPN	55839	broad.mit.edu	37	16	81050942	81050942	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:81050942C>G	uc002ffx.2	+	4	1019	c.229C>G	c.(229-231)CAT>GAT	p.H77D	CENPN_uc002ffw.3_Missense_Mutation_p.H77D|CENPN_uc010vnl.1_Missense_Mutation_p.H77D|CENPN_uc010vnm.1_Intron|CENPN_uc002ffy.3_Missense_Mutation_p.H77D	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	77					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						TATGCAATTTCATCAGCACCA	0.294			NA											65	102					0	0	0.01441	0	0
ATMIN	23300	broad.mit.edu	37	16	81069732	81069732	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:81069732G>T	uc002ffz.1	+	1	275	c.257G>T	c.(256-258)TGC>TTC	p.C86F	ATMIN_uc002fga.2_5'Flank|ATMIN_uc010vnn.1_5'Flank	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	86	C2H2-type 1.				response to DNA damage stimulus	nucleus	zinc ion binding				0						AACATCCTGTGCACCGTGCGC	0.493			NA											8	32					0.000157383	0.000162829	0.00308	1	0
TP53	7157	broad.mit.edu	37	17	7578433	7578433	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:7578433G>C	uc002gim.2	-	5	691	c.497C>G	c.(496-498)TCA>TGA	p.S166*	TP53_uc002gig.1_Nonsense_Mutation_p.S166*|TP53_uc002gih.2_Nonsense_Mutation_p.S166*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.S34*|TP53_uc010cng.1_Nonsense_Mutation_p.S34*|TP53_uc002gii.1_Nonsense_Mutation_p.S34*|TP53_uc010cnh.1_Nonsense_Mutation_p.S166*|TP53_uc010cni.1_Nonsense_Mutation_p.S166*|TP53_uc002gij.2_Nonsense_Mutation_p.S166*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.S73*|TP53_uc002gio.2_Nonsense_Mutation_p.S34*|TP53_uc010vug.1_Nonsense_Mutation_p.S127*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	166	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> T (in sporadic cancers; somatic mutation).|S -> L (in sporadic cancers; somatic mutation).|S -> A (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S166*(19)|p.0?(7)|p.S166P(5)|p.S166L(4)|p.Q167fs*14(4)|p.S166A(2)|p.S166fs*15(2)|p.S166S(2)|p.K164fs*3(2)|p.V157_C176del20(1)|p.Y163fs*1(1)|p.P151_V173del23(1)|p.K164_P219del(1)|p.S166T(1)|p.Q165_S166insYKQ(1)|p.Q165_M169delQSQHM(1)|p.Y163fs*14(1)|p.S149fs*72(1)|p.A159_Q167delAMAIYKQSQ(1)|p.S166G(1)|p.Q165_S166insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGTGCTGTGACTGCTTGTA	0.632	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			66	47					0	0	0.01441	0	0
LIG3	3980	broad.mit.edu	37	17	33329065	33329065	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:33329065G>A	uc002hik.1	+	18	2724	c.2616G>A	c.(2614-2616)AAG>AAA	p.K872K	LIG3_uc002hij.2_Silent_p.K872K	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	872					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	CCCCCAGCAAGCCCTCAGCCA	0.572			NA						Other_BER_factors					9	103					0	0	0.004482	0	0
HOXB3	3213	broad.mit.edu	37	17	46628504	46628504	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:46628504C>T	uc002inn.2	-	2	888	c.488G>A	c.(487-489)GGA>GAA	p.G163E	HOXB3_uc010wlm.1_Missense_Mutation_p.G90E|HOXB3_uc010dbf.2_Missense_Mutation_p.G163E|HOXB3_uc010dbg.2_Missense_Mutation_p.G163E|HOXB3_uc002ino.2_Missense_Mutation_p.G163E|HOXB3_uc010wlk.1_Missense_Mutation_p.G31E|HOXB3_uc010wll.1_Missense_Mutation_p.G90E	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	163	Gly-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						accactgcctccgccgccgcc	0.413			NA											5	9					0	0	0.001168	0	0
INTS2	57508	broad.mit.edu	37	17	59988888	59988888	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:59988888C>G	uc002izn.2	-	7	1047	c.971G>C	c.(970-972)GGA>GCA	p.G324A	INTS2_uc002izm.2_Missense_Mutation_p.G316A	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	324					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						CACCTGCTGTCCATTTCGGAT	0.388			NA											26	30					0	0	0.004656	0	0
DDX42	11325	broad.mit.edu	37	17	61869884	61869884	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:61869884G>A	uc002jbu.2	+	4	591	c.334G>A	c.(334-336)GAT>AAT	p.D112N	DDX42_uc002jbv.2_Missense_Mutation_p.D112N|DDX42_uc002jbw.1_5'UTR	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	112					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						TTCTGACAGCGATGATGATCC	0.398			NA											15	101					0	0	0.012319	0	0
ABCA8	10351	broad.mit.edu	37	17	66933233	66933233	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:66933233C>G	uc002jhp.2	-	4	504	c.325G>C	c.(325-327)GAT>CAT	p.D109H	ABCA8_uc002jhq.2_Missense_Mutation_p.D109H|ABCA8_uc010wqq.1_Missense_Mutation_p.D109H|ABCA8_uc010wqr.1_Missense_Mutation_p.D48H|ABCA8_uc002jhr.2_Missense_Mutation_p.D109H|ABCA8_uc002jhs.2_Missense_Mutation_p.D109H|ABCA8_uc002jht.2_Missense_Mutation_p.D109H	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	109						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CTTTCCTCATCTGGCAGTCCC	0.338			NA											21	29					0	0	0.008871	0	0
DNAI2	64446	broad.mit.edu	37	17	72295931	72295931	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:72295931T>G	uc002jkf.2	+	7	898	c.799T>G	c.(799-801)TAT>GAT	p.Y267D	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	267	WD 3.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AGACCCTGTGTATGGCACCAT	0.607			NA							Kartagener_syndrome				38	50					0	0	0.006999	0	0
SAP30BP	29115	broad.mit.edu	37	17	73689542	73689542	+	Missense_Mutation	SNP	G	G	C	rs150596591	byFrequency	TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:73689542G>C	uc002jpe.2	+	4	341	c.287G>C	c.(286-288)CGA>CCA	p.R96P	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Missense_Mutation_p.R80P	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	96					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCAGAAAAGCGAGACCCCCAG	0.552			NA											17	73					0	0	0.008871	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622174	74622174	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr17:74622174G>A	uc002jsh.2	-	7	1593	c.1419C>T	c.(1417-1419)CAC>CAT	p.H473H	ST6GALNAC1_uc002jsi.2_Silent_p.H341H|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	473	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						CCTGGGGTCTGTGCCTGTGGT	0.547			NA											61	227					0	0	0.01441	0	0
PCSK4	54760	broad.mit.edu	37	19	1483662	1483662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:1483662G>A	uc002ltb.1	-	11	1440	c.1378C>T	c.(1378-1380)CAG>TAG	p.Q460*	PCSK4_uc002lsz.2_5'UTR|PCSK4_uc002lta.2_Nonsense_Mutation_p.Q272*	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	460					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCGGCTCTGGACCCGGACG	0.617			NA											9	7					0	0	0.004007	0	0
KEAP1	9817	broad.mit.edu	37	19	10600446	10600446	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:10600446C>T	uc002moq.1	-	4	1565	c.1409G>A	c.(1408-1410)CGT>CAT	p.R470H	KEAP1_uc002mop.1_Missense_Mutation_p.R188H|KEAP1_uc002mor.1_Missense_Mutation_p.R470H	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	470	Kelch 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATAAAGGAGACGATTGAGGAC	0.562			NA											25	21					0	0	0.00278	0	0
RTBDN	83546	broad.mit.edu	37	19	12939476	12939476	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:12939476C>T	uc002mvi.2	-	4	490	c.360G>A	c.(358-360)CAG>CAA	p.Q120Q	RTBDN_uc002mvh.1_Silent_p.Q152Q|RTBDN_uc002mvj.2_Silent_p.Q152Q	NM_001080997	NP_001074466	Q9BSG5	RTBDN_HUMAN	retbindin isoform 1	120						extracellular region					0						CCTACCAGGCCTGGCAGAGCT	0.647			NA											20	55					0	0	0.003954	0	0
SLC27A1	376497	broad.mit.edu	37	19	17612097	17612097	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:17612097C>A	uc002ngu.1	+	11	1702	c.1652C>A	c.(1651-1653)GCA>GAA	p.A551E	SLC27A1_uc010xpp.1_Missense_Mutation_p.A372E|SLC27A1_uc002ngv.1_Missense_Mutation_p.A153E	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	551	Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						GAGGGTAAGGCAGGGATGGCG	0.642			NA											40	18					2.47872e-24	3.02506e-24	0.010771	1	0
ZNF208	7757	broad.mit.edu	37	19	22154332	22154332	+	Silent	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:22154332G>T	uc002nqp.2	-	6	3269	c.3120C>A	c.(3118-3120)CCC>CCA	p.P1040P	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CACATTTGTAGGGTTTCTCTA	0.363			NA											20	16					3.51602e-12	3.85088e-12	0.008871	1	0
ZNF566	84924	broad.mit.edu	37	19	36967453	36967453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:36967453G>A	uc002oea.3	-	2	89	c.7C>T	c.(7-9)CAG>TAG	p.Q3*	ZNF566_uc010xte.1_Nonsense_Mutation_p.Q3*|ZNF566_uc010xtf.1_Nonsense_Mutation_p.Q3*|ZNF566_uc002oeb.3_Nonsense_Mutation_p.Q3*|ZNF566_uc002oec.3_5'UTR|ZNF566_uc010xtg.1_5'UTR	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TATCTCACCTGAGCCATGGCT	0.398			NA											13	66					0	0	0.001855	0	0
IL28B	282617	broad.mit.edu	37	19	39734751	39734751	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:39734751A>G	uc010xut.1	-	3	309	c.305T>C	c.(304-306)CTG>CCG	p.L102P	IL28B_uc010xuu.1_Missense_Mutation_p.L102P	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	102					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CAGAACCTTCAGCGTCAGGGC	0.498			NA											29	79					0	0	0.012213	0	0
SHKBP1	92799	broad.mit.edu	37	19	41086690	41086690	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:41086690G>T	uc002oob.2	+	9	741	c.692G>T	c.(691-693)AGC>ATC	p.S231I	SHKBP1_uc002ooc.2_Missense_Mutation_p.S231I|SHKBP1_uc002ood.2_Missense_Mutation_p.S231I|SHKBP1_uc010xvl.1_Missense_Mutation_p.S154I|SHKBP1_uc002ooe.2_Missense_Mutation_p.S68I|SHKBP1_uc002oof.2_Missense_Mutation_p.S68I|SHKBP1_uc010xvm.1_Missense_Mutation_p.S68I|SHKBP1_uc010xvn.1_Missense_Mutation_p.S109I	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	231						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GTGTTTTCCAGCCCCCGCCTG	0.632			NA											73	143					2.43199e-30	3.02985e-30	0.01441	1	0
ZNF283	284349	broad.mit.edu	37	19	44351558	44351558	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:44351558G>C	uc002oxr.3	+	7	1073	c.805G>C	c.(805-807)GGG>CGG	p.G269R	ZNF283_uc002oxp.3_Missense_Mutation_p.G130R	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	269	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TAAGGAATGTGGGAAGACCTT	0.403			NA											8	65					0	0	0.00308	0	0
FBXO46	23403	broad.mit.edu	37	19	46216187	46216187	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:46216187G>C	uc002pcy.2	-	2	692	c.567C>G	c.(565-567)AGC>AGG	p.S189R	FBXO46_uc002pcz.2_Missense_Mutation_p.S189R	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	189							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GTCGTGGGTAGCTCTGCAGGG	0.697			NA											5	16					0	0	0.000602	0	0
RSPH6A	81492	broad.mit.edu	37	19	46305469	46305469	+	Silent	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:46305469C>A	uc002pdm.2	-	4	1850	c.1707G>T	c.(1705-1707)CTG>CTT	p.L569L	RSPH6A_uc002pdl.2_Silent_p.L305L	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	569	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						cctcctcccccaggtcctcct	0.398			NA											13	10					2.68362e-12	2.95001e-12	0.013537	1	0
SLC6A16	28968	broad.mit.edu	37	19	49812634	49812634	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:49812634A>C	uc002pmz.2	-	6	1145	c.911T>G	c.(910-912)ATC>AGC	p.I304S	SLC6A16_uc002pna.2_Missense_Mutation_p.I304S|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	304	Helical; Name=5; (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		ACCGACAATGATGAAACAGGG	0.493			NA											11	81					0	0	0.00245	0	0
KLK14	43847	broad.mit.edu	37	19	51581323	51581323	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:51581323C>T	uc002pvs.1	-	7	964	c.745G>A	c.(745-747)GTC>ATC	p.V249I		NM_022046	NP_071329	Q9P0G3	KLK14_HUMAN	kallikrein 14 preproprotein	249	Peptidase S1.				epidermis morphogenesis|fertilization|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis|seminal clot liquefaction	extracellular space	serine-type endopeptidase activity			skin(1)	1		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00422)		TTGGTGTAGACACCGGGGTAG	0.587	GBM(117;2161 2172 2448 22911)		NA											21	156					0	0	0.00333	0	0
ZNF611	81856	broad.mit.edu	37	19	53208732	53208732	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:53208732C>G	uc002pzz.2	-	7	1893	c.1576G>C	c.(1576-1578)GAG>CAG	p.E526Q	ZNF611_uc010eqc.2_Missense_Mutation_p.E456Q|ZNF611_uc010ydo.1_Missense_Mutation_p.E456Q|ZNF611_uc010ydr.1_Missense_Mutation_p.E457Q|ZNF611_uc010ydp.1_Missense_Mutation_p.E526Q|ZNF611_uc010ydq.1_Missense_Mutation_p.E526Q|ZNF611_uc002qaa.3_Missense_Mutation_p.E456Q	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	526	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TTATGTGTCTCAAGGCTTGAT	0.358			NA											109	196					0	0	0.01441	0	0
ZNF160	90338	broad.mit.edu	37	19	53589517	53589517	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:53589517G>T	uc010eqk.2	-	4	429	c.13C>A	c.(13-15)CAG>AAG	p.Q5K	ZNF160_uc002qaq.3_Missense_Mutation_p.Q5K|ZNF160_uc002qar.3_Missense_Mutation_p.Q5K|ZNF160_uc002qas.3_Missense_Mutation_p.Q5K	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	5					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		CACTTTACCTGAGTAAGGGCC	0.428			NA											38	84					2.87052e-16	3.3011e-16	0.005524	1	0
VSTM1	284415	broad.mit.edu	37	19	54545619	54545619	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr19:54545619G>A	uc002qcw.3	-	5	575	c.399C>T	c.(397-399)ACC>ACT	p.T133T	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Intron	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	133						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		AGATGGTTCTGGTGTCTGGAG	0.502			NA											16	47					0	0	0.00499	0	0
MSH2	4436	broad.mit.edu	37	2	47709956	47709956	+	Silent	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:47709956G>C	uc002rvy.1	+	16	2741	c.2673G>C	c.(2671-2673)GTG>GTC	p.V891V	MSH2_uc010yoh.1_Silent_p.V825V|MSH2_uc002rvz.2_Intron|MSH2_uc010fbg.2_Silent_p.V701V	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	891					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(2)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TGTCCAAGGTGAAACAAATGC	0.313			NA	D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				11	42					0	0	0.010729	0	0
ZNF638	27332	broad.mit.edu	37	2	71631126	71631126	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:71631126G>A	uc002shx.2	+	17	3275	c.2956G>A	c.(2956-2958)GAG>AAG	p.E986K	ZNF638_uc010yqw.1_Missense_Mutation_p.E565K|ZNF638_uc002shy.2_Missense_Mutation_p.E986K|ZNF638_uc002shz.2_Missense_Mutation_p.E986K|ZNF638_uc002sia.2_Missense_Mutation_p.E986K|ZNF638_uc002sib.1_Missense_Mutation_p.E986K|ZNF638_uc010fed.2_RNA|ZNF638_uc002sic.2_Missense_Mutation_p.E83K	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	986					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TATAAAAGATGAGGTAAATCA	0.328			NA											37	198					0	0	0.00623	0	0
RETSAT	54884	broad.mit.edu	37	2	85577259	85577260	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:85577259_85577260GG>AA	uc002spd.2	-	4	893_894	c.702_703CC>TT	c.(700-705)TTCCTT>TTTTTT	p.L235F	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Missense_Mutation_p.L174F|RETSAT_uc010fgf.2_Intron	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	235					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	GATGCTTGAAGGAATGGAGAGA	0.584			NA											35	211					0	0	0.004672	0	0
POLR1A	25885	broad.mit.edu	37	2	86305044	86305044	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:86305044C>T	uc002sqs.2	-	11	1697	c.1318G>A	c.(1318-1320)GCT>ACT	p.A440T		NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	440				YA -> ST (in Ref. 1; AAC99959).	termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GAGCGCGCAGCGTAGTCCACT	0.358			NA											48	216					0	0	0.01441	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626979	108626979	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:108626979G>A	uc002tdv.2	+	9	1681	c.1405G>A	c.(1405-1407)GAT>AAT	p.D469N	SLC5A7_uc010ywm.1_Missense_Mutation_p.D222N|SLC5A7_uc010fjj.2_Missense_Mutation_p.D469N|SLC5A7_uc010ywn.1_Missense_Mutation_p.D356N	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	469	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TTACCCTGATGATAATGGTAT	0.398			NA											16	113					0	0	0.004007	0	0
MARCO	8685	broad.mit.edu	37	2	119735488	119735488	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:119735488A>T	uc002tln.1	+	8	875	c.743A>T	c.(742-744)GAG>GTG	p.E248V	MARCO_uc010yyf.1_Missense_Mutation_p.E170V	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	248	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ACTAAGGGAGAGAAAGGAGAC	0.602	GBM(8;18 374 7467 11269 32796)		NA											5	20					0	0	0.000602	0	0
MYO7B	4648	broad.mit.edu	37	2	128366435	128366435	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:128366435G>A	uc002top.2	+	22	2849	c.2796G>A	c.(2794-2796)CAG>CAA	p.Q932Q		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	932						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGAGGGCCAGGCCTCGCCGC	0.622			NA											15	20					0	0	0.014323	0	0
GPR39	2863	broad.mit.edu	37	2	133174758	133174758	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:133174758A>G	uc002ttl.2	+	1	612	c.143A>G	c.(142-144)AAC>AGC	p.N48S		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	48	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						CTTCTGGGGAACAGCGCCACC	0.522			NA											92	91					0	0	0.01441	0	0
TANK	10010	broad.mit.edu	37	2	162036261	162036261	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:162036261T>A	uc002ubr.1	+	2	246	c.88T>A	c.(88-90)TTA>ATA	p.L30I	TANK_uc002ubq.1_Missense_Mutation_p.L30I|TANK_uc002ubs.2_Missense_Mutation_p.L30I	NM_004180	NP_004171	Q92844	TANK_HUMAN	TRAF interacting protein TANK isoform a	30						cytosol	metal ion binding|protein binding			ovary(1)	1						AGTAAAAGAATTACAGCAAAA	0.378			NA											4	36					0	0	0.000602	0	0
KCNH7	90134	broad.mit.edu	37	2	163253285	163253285	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:163253285C>G	uc002uch.1	-	11	2790	c.2578G>C	c.(2578-2580)GAG>CAG	p.E860Q		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	860	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	AAAGTCAACTCTAGGTTTGTT	0.363	GBM(196;1492 2208 17507 24132 45496)		NA											16	22					0	0	0.004007	0	0
LRP2	4036	broad.mit.edu	37	2	170148767	170148767	+	Silent	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:170148767T>A	uc002ues.2	-	7	978	c.765A>T	c.(763-765)GGA>GGT	p.G255G	LRP2_uc010zdf.1_Silent_p.G255G	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	255	LDL-receptor class A 6.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCTTACCACATCCATCTTCAT	0.418			NA											20	126					0	0	0.00278	0	0
DLX1	1745	broad.mit.edu	37	2	172952956	172952956	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:172952956G>C	uc002uhl.2	+	3	937	c.739G>C	c.(739-741)GAA>CAA	p.E247Q	DLX1_uc002uhm.2_3'UTR	NM_178120	NP_835221	P56177	DLX1_HUMAN	distal-less homeobox 1 isoform 1	247						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AGCGCACCAAGAAGCTATGCA	0.617			NA											7	340					0	0	0.004482	0	0
AOX1	316	broad.mit.edu	37	2	201469469	201469469	+	Silent	SNP	A	A	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:201469469A>G	uc002uvx.2	+	9	821	c.720A>G	c.(718-720)AGA>AGG	p.R240R		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	240	FAD-binding PCMH-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GCAGTGAGAGAATGATGTGGT	0.463			NA											30	117					0	0	0.009535	0	0
CLK1	1195	broad.mit.edu	37	2	201719419	201719419	+	Splice_Site	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:201719419C>A	uc002uwe.2	-	11	1322	c.1141_splice	c.e11-1	p.T381_splice	CLK1_uc002uwd.2_Splice_Site_p.T204_splice|CLK1_uc010zhi.1_Splice_Site_p.T423_splice|CLK1_uc002uwf.2_Splice_Site_p.T155_splice|CLK1_uc002uwg.2_Splice_Site_p.T230_splice|CLK1_uc010fsv.2_Splice_Site	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1						cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						TATCGTGTGTCTAGAAATAAA	0.368			NA											27	158					4.87955e-14	5.46437e-14	0.005443	1	0
AQP12B	653437	broad.mit.edu	37	2	241621963	241621963	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:241621963G>T	uc010fzj.2	-	1	355	c.292C>A	c.(292-294)CTG>ATG	p.L98M	AQP12B_uc002vzt.2_Intron	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B	86						integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		AACTCCTGCAGGGACACGGTG	0.687			NA											13	74					7.03913e-09	7.54372e-09	0.013537	1	0
RPN2	6185	broad.mit.edu	37	20	35827457	35827457	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:35827457C>G	uc002xgp.2	+	4	612	c.308C>G	c.(307-309)TCT>TGT	p.S103C	RPN2_uc002xgo.3_Missense_Mutation_p.S103C|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Missense_Mutation_p.S71C	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	103	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TCTTAGATCTCTATTTCAAAT	0.468			NA											70	164					0	0	0.01441	0	0
RPN2	6185	broad.mit.edu	37	20	35827584	35827584	+	Silent	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:35827584C>G	uc002xgp.2	+	4	739	c.435C>G	c.(433-435)CTC>CTG	p.L145L	RPN2_uc002xgo.3_Silent_p.L145L|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Silent_p.L113L	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	145	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AAGAAGCACTCAGTGCCCTTA	0.527			NA											47	140					0	0	0.011902	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356290	37356290	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:37356290C>A	uc002xjc.2	+	2	849	c.586C>A	c.(586-588)CCG>ACG	p.P196T		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	196	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CTGCTGCGCCCCGCGCTTCCC	0.632			NA											27	67					5.45727e-16	6.25181e-16	0.008361	1	0
PTPRT	11122	broad.mit.edu	37	20	40730910	40730910	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:40730910G>A	uc002xkg.2	-	26	3752	c.3568C>T	c.(3568-3570)CGG>TGG	p.R1190W	PTPRT_uc010ggj.2_Missense_Mutation_p.R1209W|PTPRT_uc010ggi.2_Missense_Mutation_p.R393W	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1190	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.		R -> W (in a colorectal cancer; reduced phosphatase activity).		homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCCTCGGGCCGCACACGGGGT	0.562			NA											5	202					0	0	0.001168	0	0
C20orf111	51526	broad.mit.edu	37	20	42831602	42831602	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:42831602C>A	uc002xlk.2	-	3	327	c.190G>T	c.(190-192)GGG>TGG	p.G64W		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	64											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			AGCTCTTACCCGTGCCAACTG	0.383			NA											19	71					1.45105e-14	1.64967e-14	0.006122	1	0
PMEPA1	56937	broad.mit.edu	37	20	56227472	56227472	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:56227472G>A	uc002xyq.2	-	4	894	c.501C>T	c.(499-501)CTC>CTT	p.L167L	PMEPA1_uc002xyr.2_Silent_p.L117L|PMEPA1_uc002xys.2_Silent_p.L132L|PMEPA1_uc002xyt.2_Silent_p.L117L	NM_020182	NP_064567	Q969W9	PMEPA_HUMAN	transmembrane prostate androgen-induced protein	167	Cytoplasmic (Potential).				androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			pancreas(1)	1						CCCGAAGCTGGAGGGTGCAGG	0.642			NA											14	68					0	0	0.001855	0	0
CABLES2	81928	broad.mit.edu	37	20	60971600	60971600	+	Silent	SNP	G	G	C	rs148559612		TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:60971600G>C	uc002ycv.2	-	2	418	c.411C>G	c.(409-411)GCC>GCG	p.A137A		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	137					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			CGCATCCCACGGCATCTTCCA	0.667			NA											9	65					0	0	0.010729	0	0
DIDO1	11083	broad.mit.edu	37	20	61511439	61511439	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:61511439G>A	uc002ydr.1	-	16	6133	c.5869C>T	c.(5869-5871)CCA>TCA	p.P1957S	DIDO1_uc002yds.1_Missense_Mutation_p.P1957S	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1957	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTGGGACCTGGCATAAAGTTA	0.587	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											7	691					0	0	0.00308	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981432	61981432	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr20:61981432G>T	uc002yes.2	-	5	1509	c.1331C>A	c.(1330-1332)CCC>CAC	p.P444H	CHRNA4_uc002yet.1_Missense_Mutation_p.P268H|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.P373H|CHRNA4_uc002yev.1_Missense_Mutation_p.P268H|CHRNA4_uc010gkf.1_Missense_Mutation_p.P268H	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	444	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCCAGGCGAGGGGTGGGGGCT	0.706			NA											17	7					3.10358e-05	3.22212e-05	0.014323	1	0
ADARB1	104	broad.mit.edu	37	21	46641940	46641940	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr21:46641940C>T	uc002zgy.2	+	12	2489	c.2054C>T	c.(2053-2055)TCC>TTC	p.S685F	ADARB1_uc002zgr.2_Missense_Mutation_p.S685F|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Missense_Mutation_p.S645F|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Missense_Mutation_p.S645F|ADARB1_uc010gpx.2_RNA|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	685	A to I editase.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		CAGGTTCCCTCCCACTTACTA	0.488			NA											33	29					0	0	0.012213	0	0
PCNT	5116	broad.mit.edu	37	21	47783764	47783764	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr21:47783764G>C	uc002zji.3	+	14	2631	c.2524G>C	c.(2524-2526)GAG>CAG	p.E842Q	PCNT_uc002zjj.2_Missense_Mutation_p.E724Q	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	842					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTGTGGGCGGGAGCCGCCCAC	0.662			NA											107	88					0	0	0.01441	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072821	17072821	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr22:17072821G>T	uc002zlp.1	-	1	880	c.620C>A	c.(619-621)GCG>GAG	p.A207E		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	207					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.A207V(1)		ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCCGGGCAGCGCGCACACCCC	0.617			NA											35	149					1.836e-18	2.16128e-18	0.003755	1	0
ZNF70	7621	broad.mit.edu	37	22	24087099	24087099	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr22:24087099G>A	uc002zxs.2	-	2	690	c.229C>T	c.(229-231)CAA>TAA	p.Q77*	ZNF70_uc002zxr.1_5'Flank	NM_021916	NP_068735	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	77						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						GGGATACTTTGATGCTGAACA	0.488			NA											55	202					0	0	0.01441	0	0
SEZ6L	23544	broad.mit.edu	37	22	26747039	26747039	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr22:26747039G>T	uc003acb.2	+	12	2585	c.2429G>T	c.(2428-2430)GGA>GTA	p.G810V	SEZ6L_uc003acc.2_Missense_Mutation_p.G810V|SEZ6L_uc011akc.1_Missense_Mutation_p.G810V|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Missense_Mutation_p.G810V|SEZ6L_uc003ace.2_Missense_Mutation_p.G810V|SEZ6L_uc003acf.1_Missense_Mutation_p.G583V|SEZ6L_uc010gvc.1_Missense_Mutation_p.G583V|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	810	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						ACCGACCCCGGAGAGGTGGAT	0.527			NA											31	214					9.8876e-21	1.18731e-20	0.004878	1	0
MN1	4330	broad.mit.edu	37	22	28193194	28193194	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr22:28193194G>A	uc003adj.2	-	1	4293	c.3338C>T	c.(3337-3339)TCG>TTG	p.S1113L		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1113							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GTCAGGGGTCGAGGTAGAGTT	0.751			NA	T	ETV6	AML|meningioma								6	10					0	0	0.001168	0	0
GAS2L1	10634	broad.mit.edu	37	22	29704500	29704500	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr22:29704500C>T	uc003afa.1	+	2	604	c.405C>T	c.(403-405)AGC>AGT	p.S135S	GAS2L1_uc010gvm.1_Silent_p.S135S|GAS2L1_uc003afb.1_Silent_p.S135S|GAS2L1_uc003afc.1_Silent_p.S135S|GAS2L1_uc003afd.1_Silent_p.S135S|GAS2L1_uc003afe.1_Silent_p.S135S	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	135	CH.				cell cycle arrest	cytoplasm|cytoskeleton					0						ACGAGAAGAGCGTGGTGCTGT	0.667			NA											5	30					0	0	0.000602	0	0
C22orf33	339669	broad.mit.edu	37	22	37387544	37387544	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr22:37387544A>T	uc003aqf.2	-	5	869	c.723T>A	c.(721-723)CAT>CAA	p.H241Q	C22orf33_uc003aqe.2_Missense_Mutation_p.H156Q	NM_001163857	NP_001157329	O43247	EAN57_HUMAN	hypothetical protein LOC339669 isoform 1	241											0						TCTTCCTGCCATGCCAGTGTT	0.542			NA											120	209					0	0	0.01441	0	0
GADL1	339896	broad.mit.edu	37	3	30769763	30769763	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:30769763C>T	uc003cep.2	-	15	1584	c.1537G>A	c.(1537-1539)GAG>AAG	p.E513K		NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	513					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	AAGTCTATCTCATCCAGGAGG	0.537			NA											58	152					0	0	0.01441	0	0
CCR8	1237	broad.mit.edu	37	3	39374435	39374435	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:39374435T>G	uc010hhr.2	+	2	751	c.613T>G	c.(613-615)TTA>GTA	p.L205V	CCR8_uc003cjm.2_Missense_Mutation_p.L122V	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	205	Helical; Name=5; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		AATGAACATTTTAGGCTTGTT	0.398			NA											56	53					0	0	0.01441	0	0
COL7A1	1294	broad.mit.edu	37	3	48626185	48626185	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:48626185G>C	uc003ctz.2	-	19	2478	c.2477C>G	c.(2476-2478)ACA>AGA	p.T826R		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	826	Nonhelical region (NC1).|Fibronectin type-III 7.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGCAGAGTCTGTGTTTCCTGG	0.607			NA											52	55					0	0	0.01441	0	0
MANF	7873	broad.mit.edu	37	3	51425216	51425216	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:51425216G>A	uc003dbc.2	+	3	342	c.280G>A	c.(280-282)GAG>AAG	p.E94K		NM_006010	NP_006001	P55145	MANF_HUMAN	mesencephalic astrocyte-derived neurotrophic	91					response to unfolded protein	extracellular region	growth factor activity				0						AATCATCAATGAGGTATCAAA	0.483			NA											11	22					0	0	0.008291	0	0
VPRBP	9730	broad.mit.edu	37	3	51440599	51440599	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:51440599C>A	uc003dbe.1	-	23	4611	c.4443G>T	c.(4441-4443)GAG>GAT	p.E1481D	VPRBP_uc003dbf.1_Missense_Mutation_p.E757D	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	1481	Asp/Glu-rich (acidic).|Interaction with NF2.				interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TCAGTTCCACCTCCTCATCTG	0.527			NA											33	26					1.49673e-21	1.80453e-21	0.00623	1	0
MINA	84864	broad.mit.edu	37	3	97669652	97669652	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:97669652C>T	uc003drz.1	-	6	1372	c.866G>A	c.(865-867)GGC>GAC	p.G289D	MINA_uc003dry.1_5'Flank|MINA_uc003dsa.1_Missense_Mutation_p.G289D|MINA_uc003dsb.1_Missense_Mutation_p.G289D|MINA_uc003dsc.1_Missense_Mutation_p.G289D|MINA_uc010hpa.1_RNA	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	289					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						CCGGGGTATGCCGGTCCGTAA	0.532			NA											5	188					0	0	0.000602	0	0
OR5H14	403273	broad.mit.edu	37	3	97868579	97868579	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:97868579C>A	uc003dsg.1	+	1	350	c.350C>A	c.(349-351)ACA>AAA	p.T117K		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTCTTGGCAACAATGGCATAT	0.388			NA											49	101					1.07234e-20	1.28252e-20	0.01441	1	0
TOMM70A	9868	broad.mit.edu	37	3	100100548	100100548	+	Silent	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:100100548C>A	uc003dtw.2	-	5	1227	c.795G>T	c.(793-795)ACG>ACT	p.T265T		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	265	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						TGATATCATCCGTGAAAGAAC	0.378			NA											42	59					6.45866e-13	7.12597e-13	0.00874	1	0
MORC1	27136	broad.mit.edu	37	3	108776234	108776234	+	Silent	SNP	G	G	A	rs144305402		TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:108776234G>A	uc003dxl.2	-	13	1218	c.1131C>T	c.(1129-1131)ATC>ATT	p.I377I	MORC1_uc011bhn.1_Silent_p.I377I	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	377					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CATGCATTTTGATCAAACGGT	0.388			NA											41	69					0	0	0.00874	0	0
ATP6V1A	523	broad.mit.edu	37	3	113505180	113505180	+	Silent	SNP	A	A	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:113505180A>C	uc003eao.2	+	6	732	c.666A>C	c.(664-666)CCA>CCC	p.P222P	ATP6V1A_uc011bik.1_Silent_p.P189P	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	222					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						AGAAGCTGCCAGCCAATCATC	0.463			NA											41	223					0	0	0.009718	0	0
CHCHD6	84303	broad.mit.edu	37	3	126676372	126676372	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:126676372G>A	uc003ejf.1	+	7	718	c.680G>A	c.(679-681)CGC>CAC	p.R227H	CHCHD6_uc010hsj.1_Missense_Mutation_p.R228H	NM_032343	NP_115719	Q9BRQ6	CHCH6_HUMAN	coiled-coil-helix-coiled-coil-helix domain	227	CHCH.										0						GCATACCAGCGCTGCGTGAGC	0.617			NA											16	22					0	0	0.004007	0	0
PLXND1	23129	broad.mit.edu	37	3	129308193	129308193	+	Splice_Site	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:129308193C>T	uc003emx.2	-	2	1588	c.1488_splice	c.e2+1	p.K496_splice		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor						axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						ACCATACCTACCTTGAGAAGC	0.667	Ovarian(97;366 1484 3738 22084 39045)		NA											10	27					0	0	0.013537	0	0
CLSTN2	64084	broad.mit.edu	37	3	139894884	139894884	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:139894884C>T	uc003etn.2	+	2	391	c.201C>T	c.(199-201)GCC>GCT	p.A67A	CLSTN2_uc003etm.2_Silent_p.A67A	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	67	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CACTGGTAGCCCTGGATAAAG	0.468	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			8	108					0	0	0.004482	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142539807	142539807	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:142539807C>T	uc003evd.2	-	8	1226	c.1030G>A	c.(1030-1032)GAG>AAG	p.E344K		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	344	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						AAATTTCCCTCTTTGTAGATG	0.507			NA											30	76					0	0	0.007291	0	0
FAM43A	131583	broad.mit.edu	37	3	194407563	194407563	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:194407563C>T	uc003fuj.2	+	1	942	c.8C>T	c.(7-9)CCG>CTG	p.P3L		NM_153690	NP_710157	Q8N2R8	FA43A_HUMAN	hypothetical protein LOC131583	3										central_nervous_system(1)	1	all_cancers(143;2.04e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.147)	OV - Ovarian serous cystadenocarcinoma(49;8.37e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.78e-05)		GAGATGCTGCCGTGGAAGAAG	0.552			NA											10	29					0	0	0.010729	0	0
TM4SF19	116211	broad.mit.edu	37	3	196050777	196050777	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr3:196050777G>T	uc003fwl.1	-	5	666	c.541C>A	c.(541-543)CTG>ATG	p.L181M	TM4SF19_uc003fwj.2_RNA|uc003fwk.1_Missense_Mutation_p.Q14H|TM4SF19_uc010iad.1_Missense_Mutation_p.F179L|TM4SF19_uc011btv.1_Missense_Mutation_p.L155M	NM_138461	NP_612470	Q96DZ7	T4S19_HUMAN	transmembrane 4 L six family member 19	181	Helical; (Potential).					integral to membrane					0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;4.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		CTGATGCACAGAAGGGCGGAG	0.567			NA											19	116					3.57192e-18	4.18826e-18	0.006122	1	0
ZNF141	7700	broad.mit.edu	37	4	367007	367007	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:367007G>A	uc003gaa.2	+	5	959	c.781G>A	c.(781-783)GGC>AGC	p.G261S	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	261	C2H2-type 4.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						TGAAGAATGTGGCAAAGCCTT	0.368			NA											91	81					0	0	0.01441	0	0
PIGG	54872	broad.mit.edu	37	4	515659	515659	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:515659G>C	uc003gak.3	+	8	1679	c.1543G>C	c.(1543-1545)GCC>CCC	p.A515P	PIGG_uc003gaj.3_Missense_Mutation_p.A507P|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.A382P|PIGG_uc003gal.3_Missense_Mutation_p.A426P|PIGG_uc003gai.2_Intron|PIGG_uc011buw.1_3'UTR|PIGG_uc003gam.2_3'UTR|PIGG_uc003gan.2_Missense_Mutation_p.A426P	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	515	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GATGGTGCTGGCCTCGGCGCT	0.587			NA											31	81					0	0	0.009535	0	0
NFXL1	152518	broad.mit.edu	37	4	47892633	47892633	+	Silent	SNP	T	T	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:47892633T>G	uc010igh.2	-	12	1717	c.1540A>C	c.(1540-1542)AGA>CGA	p.R514R	NFXL1_uc003gxp.2_Silent_p.R514R|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Silent_p.R514R	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	514	NF-X1-type 7.					integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						AGTTTACCTCTGTGACAGACA	0.333			NA											11	40					0	0	0.010729	0	0
GRSF1	2926	broad.mit.edu	37	4	71701932	71701932	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:71701932G>C	uc010iia.1	-	2	540	c.457C>G	c.(457-459)CGA>GGA	p.R153G	GRSF1_uc011caz.1_Missense_Mutation_p.R35G|GRSF1_uc003hfs.2_5'UTR	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	153	RRM 1.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			CCTTGAGCTCGAATGAGAAAG	0.388			NA											17	137					0	0	0.004007	0	0
CCDC158	339965	broad.mit.edu	37	4	77247123	77247123	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:77247123G>C	uc003hkb.3	-	22	3197	c.3044C>G	c.(3043-3045)TCT>TGT	p.S1015C		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	1015	Ser-rich.									skin(3)|ovary(2)|pancreas(1)	6						CTTCTTAGGAGAAGAATTGAA	0.358			NA											65	214					0	0	0.01441	0	0
TRPC3	7222	broad.mit.edu	37	4	122828657	122828657	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:122828657C>A	uc003ieg.2	-	7	1932	c.1858G>T	c.(1858-1860)GTG>TTG	p.V620L	TRPC3_uc010inr.2_Missense_Mutation_p.V492L|TRPC3_uc003ief.2_Missense_Mutation_p.V547L|TRPC3_uc011cgl.1_Missense_Mutation_p.V284L	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	535	Helical; (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AAGCTGAGCACAACAGCTATG	0.443			NA											39	42					3.61848e-18	4.22627e-18	0.007835	1	0
PHF17	79960	broad.mit.edu	37	4	129789088	129789088	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:129789088C>G	uc003igk.2	+	10	1861	c.1581C>G	c.(1579-1581)TTC>TTG	p.F527L	PHF17_uc003igl.2_Missense_Mutation_p.F515L|PHF17_uc011cgy.1_Missense_Mutation_p.F527L	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	527					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						AACAGATATTCAATCTTTACA	0.418			NA											19	32					0	0	0.010504	0	0
FAT1	2195	broad.mit.edu	37	4	187628476	187628476	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr4:187628476C>A	uc003izf.2	-	2	2694	c.2506G>T	c.(2506-2508)GAG>TAG	p.E836*	FAT1_uc010iso.1_Nonsense_Mutation_p.E836*	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	836	Extracellular (Potential).|Cadherin 7.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CTATGTACCTCCTTGTCTTCA	0.473	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			95	84					2.1089e-46	2.70627e-46	0.01441	1	0
TRIO	7204	broad.mit.edu	37	5	14291189	14291189	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:14291189C>T	uc003jff.2	+	5	911	c.905C>T	c.(904-906)GCG>GTG	p.A302V	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.A253V|TRIO_uc003jfh.1_5'Flank	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	302					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCAGGCAATGCGGACCTGCAG	0.562			NA											5	222					0	0	0.000602	0	0
CDH9	1007	broad.mit.edu	37	5	26881693	26881693	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:26881693T>C	uc003jgs.1	-	12	2091	c.1922A>G	c.(1921-1923)AAA>AGA	p.K641R	CDH9_uc011cnv.1_Missense_Mutation_p.K234R	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	641	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AGGTTCCTTTTTTCTTTGCCT	0.388	Melanoma(8;187 585 15745 40864 52829)		NA											16	61					0	0	0.00499	0	0
PDZD2	23037	broad.mit.edu	37	5	31799826	31799826	+	Silent	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:31799826G>C	uc003jhl.2	+	2	859	c.471G>C	c.(469-471)GGG>GGC	p.G157G	PDZD2_uc003jhm.2_Silent_p.G157G	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	157	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						ATGTCAGTGGGGCCAGGTAAG	0.572			NA											7	222					0	0	0.001984	0	0
WDR70	55100	broad.mit.edu	37	5	37727024	37727024	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:37727024C>G	uc003jkv.2	+	17	1812	c.1754C>G	c.(1753-1755)TCT>TGT	p.S585C		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	585										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGCACTCTCTCTTCCTATATT	0.448			NA											79	183					0	0	0.01441	0	0
EGFLAM	133584	broad.mit.edu	37	5	38406296	38406296	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:38406296G>A	uc003jlc.1	+	7	1105	c.781G>A	c.(781-783)GAT>AAT	p.D261N	EGFLAM_uc003jlb.1_Missense_Mutation_p.D261N|EGFLAM_uc003jle.1_Missense_Mutation_p.D27N|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	261						cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TGGTGAGGATGATGAAGGATT	0.473	Colon(62;485 1295 3347 17454)		NA											36	54					0	0	0.003271	0	0
CMYA5	202333	broad.mit.edu	37	5	79054629	79054629	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:79054629A>G	uc003kgc.2	+	7	11236	c.11164A>G	c.(11164-11166)ACA>GCA	p.T3722A		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3722	Fibronectin type-III 1.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CACCAGCACAACAATTGCAGT	0.378			NA											38	30					0	0	0.005524	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101631628	101631628	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:101631628G>A	uc003knm.2	-	1	626	c.339C>T	c.(337-339)CTC>CTT	p.L113L		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	113	Helical; Name=1; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TGACGGCCAAGAGGCAGTAGT	0.632			NA											39	34					0	0	0.00874	0	0
FBN2	2201	broad.mit.edu	37	5	127599169	127599169	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:127599169C>A	uc003kuu.2	-	63	8579	c.8140G>T	c.(8140-8142)GAG>TAG	p.E2714*		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2714	EGF-like 47; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TAGCCCCCCTCCGTGTTAGAG	0.587			NA											50	59					1.42676e-28	1.76282e-28	0.01441	1	0
SLC22A4	6583	broad.mit.edu	37	5	131630701	131630701	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:131630701A>T	uc003kwq.2	+	1	557	c.392A>T	c.(391-393)GAG>GTG	p.E131V	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	131	Extracellular (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GTCGTGACCGAGGTGGGTGCC	0.701			NA											10	6					0	0	0.010729	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431299	140431299	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:140431299G>C	uc003lik.1	+	1	321	c.244G>C	c.(244-246)GGA>CGA	p.G82R		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	82	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGCAAGACGGGAGATTTGTT	0.572			NA											22	61					0	0	0.014323	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503320	140503320	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:140503320G>A	uc003lip.1	+	1	1740	c.1740G>A	c.(1738-1740)GAG>GAA	p.E580E		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	580	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCGGCCGAGCCGGGCTACC	0.697			NA											38	29					0	0	0.01441	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553584	140553584	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:140553584C>T	uc003lit.2	+	1	1342	c.1168C>T	c.(1168-1170)CCC>TCC	p.P390S		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	390	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACGATGTCCCCTTCATCCT	0.473			NA											43	34					0	0	0.007835	0	0
HRH2	3274	broad.mit.edu	37	5	175111158	175111158	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:175111158G>A	uc003mdd.2	+	1	2695	c.922G>A	c.(922-924)GCC>ACC	p.A308T	HRH2_uc003mdc.3_Missense_Mutation_p.A308T	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	308	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CTGCAGGCTGGCCAACCGCAA	0.582			NA											4	117					0	0	0.009096	0	0
RMND5B	64777	broad.mit.edu	37	5	177570722	177570722	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr5:177570722C>T	uc003mim.2	+	6	701	c.521C>T	c.(520-522)GCG>GTG	p.A174V	RMND5B_uc003min.2_Missense_Mutation_p.A174V|RMND5B_uc003mio.2_Missense_Mutation_p.A161V|RMND5B_uc003mip.2_Missense_Mutation_p.A174V|RMND5B_uc011dgf.1_Missense_Mutation_p.A215V|RMND5B_uc003miq.2_Missense_Mutation_p.A114V	NM_022762	NP_073599	Q96G75	RMD5B_HUMAN	required for meiotic nuclear division 5 homolog	174	CTLH.									ovary(1)|skin(1)	2	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGGTCCTGCGTTGGAGTAA	0.527			NA											19	40					0	0	0.007413	0	0
RPP40	10799	broad.mit.edu	37	6	4996626	4996626	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:4996626A>T	uc003mwl.2	-	6	623	c.588T>A	c.(586-588)TAT>TAA	p.Y196*	RPP40_uc003mwm.2_Nonsense_Mutation_p.Y173*	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	196					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				ACTTGGAAAAATATGACATCA	0.453			NA											17	161					0	0	0.00499	0	0
SLC44A4	80736	broad.mit.edu	37	6	31833121	31833121	+	Silent	SNP	C	C	T	rs142009471		TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:31833121C>T	uc010jti.2	-	17	1797	c.1731G>A	c.(1729-1731)GCG>GCA	p.A577A	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	577	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	GTAGCATGAACGCATTTTTGG	0.562			NA											52	270					0	0	0.01441	0	0
ITPR3	3710	broad.mit.edu	37	6	33632679	33632679	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:33632679C>A	uc011drk.1	+	12	1400	c.1181C>A	c.(1180-1182)ACC>AAC	p.T394N		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	394	Cytoplasmic (Potential).|MIR 5.				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CACCTCTGCACCAACACGTGG	0.567			NA											24	48					2.48779e-11	2.70491e-11	0.005443	1	0
TTBK1	84630	broad.mit.edu	37	6	43225669	43225669	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:43225669C>T	uc003ouq.1	+	10	1260	c.981C>T	c.(979-981)CCC>CCT	p.P327P		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	327						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CTACCCCGCCCCAGCAGAACA	0.627			NA											44	31					0	0	0.01441	0	0
SLC35A1	10559	broad.mit.edu	37	6	88218187	88218187	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:88218187G>A	uc011dzj.1	+	6	703	c.624G>A	c.(622-624)GTG>GTA	p.V208V	SLC35A1_uc003plx.2_RNA|SLC35A1_uc010kbw.2_Silent_p.V56V|SLC35A1_uc003plz.2_Intron|SLC35A1_uc011dzi.1_Silent_p.V74V|SLC35A1_uc003ply.2_Intron|SLC35A1_uc010kbx.2_Intron|SLC35A1_uc010kby.2_Intron|SLC35A1_uc011dzk.1_5'Flank	NM_006416	NP_006407	P78382	S35A1_HUMAN	solute carrier family 35 (CMP-sialic acid	208	Cytoplasmic (Potential).				carbohydrate metabolic process|protein modification process	Golgi membrane|integral to plasma membrane	CMP-N-acetylneuraminate transmembrane transporter activity|sugar:hydrogen symporter activity				0		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTCTTTGGGTGAGAAACATTC	0.294	NSCLC(183;214 2117 17033 22638 44782)|Ovarian(87;1008 1343 9644 42916 50932)		NA											16	14					0	0	0.010504	0	0
SPACA1	81833	broad.mit.edu	37	6	88773828	88773828	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:88773828A>T	uc003pmn.2	+	6	739	c.622A>T	c.(622-624)AGA>TGA	p.R208*		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	208	Extracellular (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		ATTGCAGATGAGAAGATCAAG	0.323			NA											5	54					0	0	0.000602	0	0
UBE2J1	51465	broad.mit.edu	37	6	90062268	90062268	+	Silent	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:90062268C>A	uc010kcb.2	-	2	194	c.21G>T	c.(19-21)CTG>CTT	p.L7L	UBE2J1_uc003pnc.2_Silent_p.L7L	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	7	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		CCGGACTCTTCAGGTTGTAGC	0.756			NA											15	7					4.7546e-09	5.11376e-09	0.004007	1	0
AKD1	221264	broad.mit.edu	37	6	109814589	109814589	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:109814589C>T	uc003ptn.2	-	41	5796	c.5719G>A	c.(5719-5721)GAC>AAC	p.D1907N	AKD1_uc011eas.1_Missense_Mutation_p.D292N	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1907					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTAATTGGGTCTATATTTCTG	0.383			NA											81	58					0	0	0.01441	0	0
FAM184A	79632	broad.mit.edu	37	6	119345909	119345909	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:119345909C>T	uc003pyj.2	-	2	577	c.229G>A	c.(229-231)GAA>AAA	p.E77K	FAM184A_uc003pyk.3_5'UTR|FAM184A_uc003pyl.3_5'UTR	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	77	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						ATTTCTTCTTCATGAGCATCT	0.338			NA											33	21					0	0	0.010818	0	0
FAM120B	84498	broad.mit.edu	37	6	170627094	170627094	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr6:170627094C>G	uc003qxp.2	+	2	724	c.616C>G	c.(616-618)CTC>GTC	p.L206V	FAM120B_uc003qxo.1_Missense_Mutation_p.L206V|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	206					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		CACCGTCATGCTCTGCAGAGA	0.527			NA											33	132					0	0	0.012213	0	0
USP42	84132	broad.mit.edu	37	7	6189291	6189291	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr7:6189291C>T	uc011jwo.1	+	13	1587	c.1464C>T	c.(1462-1464)TCC>TCT	p.S488S	USP42_uc010kth.1_Silent_p.S421S|USP42_uc011jwp.1_Silent_p.S488S|USP42_uc011jwq.1_Silent_p.S295S|USP42_uc011jwr.1_Silent_p.S333S	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	488					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		ACGGGAATTCCAGTGTCAACA	0.463			NA											66	108					0	0	0.01441	0	0
ZNF655	79027	broad.mit.edu	37	7	99171066	99171066	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr7:99171066C>T	uc003urh.2	+	3	1728	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	ZNF655_uc010lga.2_Silent_p.F480F|ZNF655_uc010lgc.2_Silent_p.F480F|ZNF655_uc003urj.2_Silent_p.F445F|ZNF655_uc003urk.2_Silent_p.F282F|ZNF655_uc010lgd.2_Silent_p.F282F	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	445					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AGGGCAGTTTCAGTCATAGCT	0.408			NA											40	81					0	0	0.00874	0	0
LRCH4	4034	broad.mit.edu	37	7	100179736	100179736	+	Silent	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr7:100179736G>T	uc003uvj.2	-	3	473	c.420C>A	c.(418-420)GTC>GTA	p.V140V	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	140	LRR 5.				nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGACGATGAGGACCCTCAGGG	0.637			NA											27	61					5.77227e-19	6.82177e-19	0.008361	1	0
SPAM1	6677	broad.mit.edu	37	7	123599915	123599915	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr7:123599915G>A	uc003vld.2	+	6	1824	c.1422G>A	c.(1420-1422)GAG>GAA	p.E474E	SPAM1_uc003vle.2_Silent_p.E474E|SPAM1_uc011koa.1_Silent_p.E130E|SPAM1_uc003vlf.3_Silent_p.E474E|SPAM1_uc010lku.2_Silent_p.E474E	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	474					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	CTCCCATGGAGACAGAAGAAC	0.383			NA											16	46					0	0	0.004007	0	0
GALNT11	63917	broad.mit.edu	37	7	151818708	151818708	+	Silent	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr7:151818708C>T	uc010lqg.1	+	12	2003	c.1773C>T	c.(1771-1773)GTC>GTT	p.V591V	GALNT11_uc011kvm.1_Silent_p.V510V|GALNT11_uc003wku.2_Silent_p.V591V	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	591	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		AGGGCTCTGTCGCCATGGCGA	0.532			NA											27	72					0	0	0.007291	0	0
MLL3	58508	broad.mit.edu	37	7	151945303	151945303	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr7:151945303G>C	uc003wla.2	-	14	2435	c.2216C>G	c.(2215-2217)TCT>TGT	p.S739C		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	739					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGTCATTTCAGAGTCCATCAA	0.363	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								3	78					0	0	0.009096	0	0
C8orf79	57604	broad.mit.edu	37	8	12878691	12878692	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:12878691_12878692TC>AA	uc010lsq.2	+	5	995_996	c.503_504TC>AA	c.(502-504)CTC>CAA	p.L168Q	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Missense_Mutation_p.L81Q|C8orf79_uc010lsr.2_Missense_Mutation_p.L42Q	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	168							methyltransferase activity				0						TGTTCCCAGCTCTTCTCAGAGT	0.51			NA											9	52					0	0	0.004672	0	0
LZTS1	11178	broad.mit.edu	37	8	20112537	20112537	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:20112537G>A	uc003wzr.2	-	1	267	c.156C>T	c.(154-156)CAC>CAT	p.H52H	LZTS1_uc010ltg.1_Silent_p.H52H	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	52					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TGGACTTGCCGTGACCGGAGT	0.577			NA											71	69					0	0	0.01441	0	0
GPR124	25960	broad.mit.edu	37	8	37692771	37692771	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:37692771G>A	uc003xkj.2	+	12	2051	c.1688G>A	c.(1687-1689)AGG>AAG	p.R563K	GPR124_uc010lvy.2_Intron	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	563	Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCCTTCCAGAGGAGGGAGGGA	0.672			NA											23	52					0	0	0.003954	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38205058	38205058	+	Missense_Mutation	SNP	C	C	T	rs142206759		TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:38205058C>T	uc003xli.2	-	2	1150	c.632G>A	c.(631-633)CGC>CAC	p.R211H	WHSC1L1_uc011lbm.1_Missense_Mutation_p.R211H|WHSC1L1_uc010lwe.2_Missense_Mutation_p.R211H|WHSC1L1_uc003xlj.2_Missense_Mutation_p.R211H	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	211					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GTGTGACTTGCGCTCTTCAGA	0.353			NA	T	NUP98	AML								47	160					0	0	0.01441	0	0
MSC	9242	broad.mit.edu	37	8	72754901	72754901	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:72754901C>T	uc003xyx.1	-	2	934	c.616G>A	c.(616-618)GCT>ACT	p.A206T	uc011lff.1_5'Flank|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	206					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			CCGATTTAAGCGGTGGTTCCA	0.493			NA											182	605					0	0	0.01441	0	0
PI15	51050	broad.mit.edu	37	8	75756265	75756266	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:75756265_75756266GC>AT	uc003yal.2	+	3	502_503	c.323_324GC>AT	c.(322-324)TGC>TAT	p.C108Y	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.C108Y	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	108						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GCGGCTACTTGCATTTGGGACC	0.431			NA											29	128					0	0	0.004672	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617598	77617598	+	Silent	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:77617598C>A	uc003yav.2	+	2	1662	c.1275C>A	c.(1273-1275)CTC>CTA	p.L425L	ZFHX4_uc003yat.1_Silent_p.L425L|ZFHX4_uc003yau.1_Silent_p.L425L|ZFHX4_uc003yaw.1_Silent_p.L425L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	425						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTGTCTCCCTCAGCCACTCAT	0.502			NA								HNSCC(33;0.089)			20	33					8.34094e-07	8.75067e-07	0.008871	1	0
ZFHX4	79776	broad.mit.edu	37	8	77617600	77617600	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:77617600G>A	uc003yav.2	+	2	1664	c.1277G>A	c.(1276-1278)AGC>AAC	p.S426N	ZFHX4_uc003yat.1_Missense_Mutation_p.S426N|ZFHX4_uc003yau.1_Missense_Mutation_p.S426N|ZFHX4_uc003yaw.1_Missense_Mutation_p.S426N	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	426						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTCTCCCTCAGCCACTCATCG	0.502			NA								HNSCC(33;0.089)			21	33					0	0	0.008871	0	0
EBAG9	9166	broad.mit.edu	37	8	110576697	110576697	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr8:110576697G>C	uc003ynf.2	+	7	786	c.551G>C	c.(550-552)AGA>ACA	p.R184T	EBAG9_uc003yng.2_Missense_Mutation_p.R184T	NM_198120	NP_936056	O00559	RCAS1_HUMAN	estrogen receptor binding site associated	184	Cytoplasmic (Potential).|Potential.				apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity				0			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)			AGAGAAAAGAGAGCAGCCGAA	0.343			NA											17	39					0	0	0.007413	0	0
C9orf131	138724	broad.mit.edu	37	9	35042966	35042966	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:35042966C>A	uc003zvw.2	+	2	369	c.340C>A	c.(340-342)CTG>ATG	p.L114M	C9orf131_uc003zvu.2_Missense_Mutation_p.L66M|C9orf131_uc003zvv.2_Missense_Mutation_p.L41M|C9orf131_uc003zvx.2_Missense_Mutation_p.L79M	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	114											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			cgaggCATCTCTGGATCCACT	0.428			NA											54	43					2.01872e-29	2.50455e-29	0.01441	1	0
VCP	7415	broad.mit.edu	37	9	35059557	35059557	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:35059557G>T	uc003zvy.2	-	14	2326	c.1937C>A	c.(1936-1938)CCA>CAA	p.P646Q	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.P315Q|VCP_uc010mki.1_Missense_Mutation_p.P601Q	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	646					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ATCAGGAAGTGGGATGTAGAT	0.522			NA											39	46					1.49673e-21	1.80453e-21	0.00623	1	0
RECK	8434	broad.mit.edu	37	9	36112407	36112407	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:36112407A>T	uc003zyv.2	+	16	2080	c.1994A>T	c.(1993-1995)CAG>CTG	p.Q665L	RECK_uc003zyw.2_Missense_Mutation_p.Q537L|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	665	Kazal-like 1.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CAAGACCATCAGTTTGAGTTT	0.448			NA											43	68					0	0	0.01441	0	0
GOLM1	51280	broad.mit.edu	37	9	88661457	88661457	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:88661457C>G	uc004aol.2	-	5	593	c.395G>C	c.(394-396)GGC>GCC	p.G132A	GOLM1_uc010mqd.1_RNA|GOLM1_uc004aom.2_Missense_Mutation_p.G132A	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	132	Potential.|Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						CTGCAGCCTGCCGTAATTCCT	0.532			NA											13	10					0	0	0.001855	0	0
HSDL2	84263	broad.mit.edu	37	9	115171264	115171264	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:115171264C>G	uc004bga.1	+	4	451	c.358C>G	c.(358-360)CTG>GTG	p.L120V	HSDL2_uc011lwv.1_Translation_Start_Site|HSDL2_uc004bgb.1_Intron|HSDL2_uc004bgc.1_Intron|HSDL2_uc011lww.1_Translation_Start_Site	NM_032303	NP_115679	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	120						peroxisome	oxidoreductase activity|sterol binding				0						GAGATTGGATCTGATGATGAA	0.408			NA											28	67					0	0	0.013726	0	0
GOLGA1	2800	broad.mit.edu	37	9	127693657	127693657	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:127693657T>C	uc004bpc.2	-	4	506	c.164A>G	c.(163-165)GAT>GGT	p.D55G	GOLGA1_uc010mwt.1_Missense_Mutation_p.D55G	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	55	Potential.					Golgi cisterna membrane				ovary(1)	1						GGATGAAAGATCTTCTCTGGA	0.433			NA											39	22					0	0	0.007835	0	0
TTC16	158248	broad.mit.edu	37	9	130479208	130479208	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:130479208T>A	uc004brq.1	+	2	171	c.104T>A	c.(103-105)ATC>AAC	p.I35N	PTRH1_uc004brm.2_5'Flank|PTRH1_uc004bro.2_5'Flank|PTRH1_uc010mxm.2_5'UTR|PTRH1_uc011mah.1_5'UTR|TTC16_uc011mai.1_Missense_Mutation_p.I35N|TTC16_uc004brr.1_5'Flank	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	35							binding				0						CTGCAGCACATCTTTGGGACC	0.542			NA											47	36					0	0	0.01441	0	0
NOXA1	10811	broad.mit.edu	37	9	140327948	140327948	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:140327948T>C	uc004cmv.2	+	11	1088	c.953T>C	c.(952-954)GTG>GCG	p.V318A	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Missense_Mutation_p.V318A|NOXA1_uc010nch.2_Missense_Mutation_p.V262A	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	318	OPR.		Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).		regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		ACTGTCACCGTGCAGTGCGCC	0.711			NA											5	7					0	0	0.000602	0	0
NLGN4X	57502	broad.mit.edu	37	X	5827175	5827176	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chrX:5827175_5827176TC>AA	uc010ndh.2	-	4	1231_1232	c.730_731GA>TT	c.(730-732)GAC>TTC	p.D244F	NLGN4X_uc004crp.2_Missense_Mutation_p.D264F|NLGN4X_uc004crq.2_Missense_Mutation_p.D244F|NLGN4X_uc010ndi.2_Missense_Mutation_p.D281F|NLGN4X_uc004crr.2_Missense_Mutation_p.D244F|NLGN4X_uc010ndj.2_Missense_Mutation_p.D244F	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	244	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TCTCTTGGGGTCCCCGCCAAAG	0.569			NA											18	47					0	0	0.004672	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766598	27766598	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chrX:27766598C>T	uc011mjy.1	+	1	1673	c.1586C>T	c.(1585-1587)GCG>GTG	p.A529V		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						CCTGTGTTGGCGTGCAGTGGC	0.473			NA											17	4					0	0	0.004007	0	0
FAM47B	170062	broad.mit.edu	37	X	34962140	34962140	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chrX:34962140C>T	uc004ddi.1	+	1	1210	c.1192C>T	c.(1192-1194)CGC>TGC	p.R398C		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	398										ovary(3)|breast(1)	4						GCCCCATCTCCGCCTGGTGCT	0.582			NA											47	18					0	0	0.01441	0	0
PHF16	9767	broad.mit.edu	37	X	46913983	46913983	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chrX:46913983C>T	uc004dgx.2	+	9	1447	c.1396C>T	c.(1396-1398)CAC>TAC	p.H466Y	PHF16_uc004dgy.2_Missense_Mutation_p.H466Y	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	466					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						GGAAAGCATTCACACTCGAAT	0.453			NA											18	16					0	0	0.00499	0	0
TNMD	64102	broad.mit.edu	37	X	99854065	99854065	+	Silent	SNP	C	C	G			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chrX:99854065C>G	uc004efy.3	+	6	856	c.630C>G	c.(628-630)GCC>GCG	p.A210A	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	210	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						ACTTTCCTGCCAACGAAAAAA	0.423			NA											16	5					0	0	0.004007	0	0
FLNA	2316	broad.mit.edu	37	X	153593044	153593044	+	Silent	SNP	G	G	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chrX:153593044G>A	uc004fkk.2	-	13	2121	c.1872C>T	c.(1870-1872)GAC>GAT	p.D624D	FLNA_uc010nuu.1_Silent_p.D624D	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	624	Filamin 4.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGCCCTTGTCGTCACATTCGA	0.632			NA											44	64					0	0	0.01441	0	0
C1orf168	199920	broad.mit.edu	37	1	57219538	57219538	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr1:57219538delC	uc001cym.3	-	8	1607	c.1201delG	c.(1201-1203)GAAfs	p.E401fs	C1orf168_uc009vzu.1_Intron|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	401										ovary(3)|skin(2)	5						GAATATGGTTCCTTTTCTGTG	0.353			NA											14	60	---	---	---	---	NA	NA	NA	NA	NA
TAS2R31	259290	broad.mit.edu	37	12	11183906	11183907	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr12:11183906_11183907insA	uc001qzo.1	-	1	100_101	c.28_29insT	c.(28-30)TCCfs	p.S10fs	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	10	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						TACCACACTGGAAAAAATGATG	0.282			NA											7	69	---	---	---	---	NA	NA	NA	NA	NA
ABCC1	4363	broad.mit.edu	37	16	16177395	16177397	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	AGA	AGA	-	-	AGA	AGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr16:16177395_16177397delAGA	uc010bvi.2	+	17	2463_2465	c.2288_2290delAGA	c.(2287-2292)GAGAAG>GAG	p.K764del	ABCC1_uc010bvj.2_Intron|ABCC1_uc010bvk.2_In_Frame_Del_p.K764del|ABCC1_uc010bvl.2_In_Frame_Del_p.K764del|ABCC1_uc010bvm.2_Intron|ABCC1_uc002del.3_In_Frame_Del_p.K648del	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	764	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GAGATTGGCGAGAAGGTCAGTAT	0.542			NA											27	221	---	---	---	---	NA	NA	NA	NA	NA
FSHR	2492	broad.mit.edu	37	2	49217718	49217718	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:49217718delG	uc002rww.2	-	5	507	c.433delC	c.(433-435)CAAfs	p.Q145fs	FSHR_uc002rwx.2_Frame_Shift_Del_p.Q145fs|FSHR_uc010fbn.2_Frame_Shift_Del_p.Q145fs|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	145	LRR 5.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	AAAACTTTTTGGAGAGAATGA	0.383			NA							Gonadal_Dysgenesis_46_XX				23	107	---	---	---	---	NA	NA	NA	NA	NA
EIF5B	9669	broad.mit.edu	37	2	99993096	99993102	+	Splice_Site	DEL	TGAGGTA	TGAGGTA	-			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	TGAGGTA	TGAGGTA	-	-	TGAGGTA	TGAGGTA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr2:99993096_99993102delTGAGGTA	uc002tab.2	+	10	2026	c.1842_splice	c.e10+1	p.E614_splice		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						AACGGAGGATTGAGGTATTTATTTTAC	0.362	Colon(162;2388 2567 2705 3444)		NA											12	130	---	---	---	---	NA	NA	NA	NA	NA
CDKN2A	1029	broad.mit.edu	37	9	21971057	21971058	+	Frame_Shift_Ins	INS	-	-	A	rs104894094		TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:21971057_21971058insA	uc003zpk.2	-	2	512_513	c.300_301insT	c.(298-303)GCCGGGfs	p.A100fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Ins_p.R156fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	100_101	ANK 3.		G -> W (in CMM2 and FAMMMPC; impairs the function).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.A100S(3)|p.A100P(2)|p.H83fs*2(2)|p.A102fs*18(1)|p.A100V(1)|p.G101fs*17(1)|p.T93_D105del(1)|p.A68fs*3(1)|p.G101W(1)|p.A102fs*42(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		AGCCGCGCCCCGGCCCGGTGCA	0.752			17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			14	24	---	---	---	---	NA	NA	NA	NA	NA
FAM75A2	642265	broad.mit.edu	37	9	39361117	39361117	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1594-01A-01D-1040-01	TCGA-55-1594-11A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	88620207-646f-49ec-bb4f-7e8fd22e77ae	087484e8-dc3e-461a-be5f-4217b7c39732	g.chr9:39361117delG	uc004abm.2	+	4	3384	c.3355delG	c.(3355-3357)GAAfs	p.E1119fs		NM_001040065	NP_001035154	Q5RGS2	F75A2_HUMAN	hypothetical protein LOC642265	1119						integral to membrane					0				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GCCCAACTTAGAAAAACATGA	0.488			NA											62	203	---	---	---	---	NA	NA	NA	NA	NA