Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUL1	79594	broad.mit.edu	37	1	20827839	20827839	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr1:20827839C>T	uc001bdi.3	-	4	560	c.403G>A	c.(403-405)GTG>ATG	p.V135M		NM_024544	NP_078820	Q969V5	MUL1_HUMAN	mitochondrial ubiquitin ligase activator of NFKB	135	Mitochondrial intermembrane (Potential).				activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GCCACATCCACGCCATCCTCG	0.507			NA											15	101					0	0	0.00499	0	0
BCL10	8915	broad.mit.edu	37	1	85733383	85733383	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr1:85733383T>G	uc001dkz.2	-	4	1334	c.629A>C	c.(628-630)GAA>GCA	p.E210A		NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	210			Missing (in follicular lymphoma).		apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		TCCTTCTTCTTCTAACTGTAG	0.423	NSCLC(34;993 1034 12176 32621 50182)		NA	T	IGH@	MALT 								4	66					0	0	0.000248	0	0
NTM	50863	broad.mit.edu	37	11	132082022	132082022	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr11:132082022G>C	uc001qgp.2	+	3	1171	c.507G>C	c.(505-507)TGG>TGC	p.W169C	NTM_uc001qgm.2_Missense_Mutation_p.W169C|NTM_uc010sch.1_Missense_Mutation_p.W160C|NTM_uc010sci.1_Missense_Mutation_p.W169C|NTM_uc010scj.1_Missense_Mutation_p.W128C|NTM_uc001qgo.2_Missense_Mutation_p.W169C|NTM_uc001qgq.2_Missense_Mutation_p.W169C|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	169	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						CGGTTACTTGGAGACACATCT	0.433			NA											3	102					0	0	0.004672	0	0
WNK1	65125	broad.mit.edu	37	12	993965	993965	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr12:993965C>T	uc001qio.3	+	19	4502	c.3995C>T	c.(3994-3996)ACA>ATA	p.T1332I	WNK1_uc001qip.3_Missense_Mutation_p.T1085I|WNK1_uc001qir.3_Missense_Mutation_p.T505I	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1332					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACAGGACCAACATTTCCAGTA	0.493	Colon(19;451 567 6672 12618 28860)		NA											7	63					0	0	0.001984	0	0
ITGA5	3678	broad.mit.edu	37	12	54799449	54799449	+	Missense_Mutation	SNP	C	C	T	rs141341610	byFrequency	TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr12:54799449C>T	uc001sga.2	-	11	1083	c.1015G>A	c.(1015-1017)GGG>AGG	p.G339R	ITGA5_uc010sow.1_RNA|ITGA5_uc009znp.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	339	Potential.|Extracellular (Potential).|FG-GAP 5.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						ACCACTCACCCATCCCCATTG	0.552			NA											9	62					0	0	0.001855	0	0
SYNE2	23224	broad.mit.edu	37	14	64519395	64519395	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr14:64519395A>G	uc001xgm.2	+	48	8994	c.8764A>G	c.(8764-8766)ATT>GTT	p.I2922V	SYNE2_uc001xgl.2_Missense_Mutation_p.I2922V	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2922	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAATCTTAAGATTAGGACCAA	0.348			NA											6	18					0	0	0.001168	0	0
YBX2	51087	broad.mit.edu	37	17	7192945	7192945	+	Silent	SNP	G	G	A			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr17:7192945G>A	uc002gfq.2	-	7	1005	c.948C>T	c.(946-948)CCC>CCT	p.P316P		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	316	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GTGGGCGCTGGGGCTCAGGCC	0.721			NA											9	27					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	17	43625427	43625427	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr17:43625427G>C	uc002ijh.2	-	1	698	c.577C>G	c.(577-579)CCC>GCC	p.P193A	uc010wjv.1_Intron					Homo sapiens cDNA FLJ45049 fis, clone BRAWH3022347.												NA						TCTGTAGTGGGTTCTGGAATG	0.507			NA											27	186					0	0	0.00632	0	0
POTEC	388468	broad.mit.edu	37	18	14524916	14524916	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr18:14524916G>C	uc010dln.2	-	7	1647	c.1193C>G	c.(1192-1194)CCA>CGA	p.P398R	POTEC_uc010xaj.1_Intron	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	398										skin(3)	3						CCATGCCTCTGGCTGGCTATT	0.308			NA											4	61					0	0	0.000248	0	0
DOK6	220164	broad.mit.edu	37	18	67365760	67365760	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr18:67365760T>A	uc002lkl.2	+	5	720	c.530T>A	c.(529-531)GTG>GAG	p.V177E		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	177	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GTCAAACTGGTGATGTGGCCT	0.473			NA											4	44					0	0	0.000248	0	0
ZNF780A	284323	broad.mit.edu	37	19	40587729	40587729	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr19:40587729G>C	uc002omy.2	-	5	454	c.229C>G	c.(229-231)CCA>GCA	p.P77A	ZNF780A_uc002omw.3_Missense_Mutation_p.P93A|ZNF780A_uc002omz.2_Missense_Mutation_p.P77A|ZNF780A_uc010xvh.1_Missense_Mutation_p.P78A	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CACTTACCTGGATACCGTCTG	0.448			NA											10	87					0	0	0.008291	0	0
CD8B	926	broad.mit.edu	37	2	87085348	87085348	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr2:87085348T>G	uc002srz.2	-	2	285	c.235A>C	c.(235-237)ACT>CCT	p.T79P	RMND5A_uc002srs.3_Intron|CD8B_uc002srw.2_Missense_Mutation_p.T79P|CD8B_uc002srx.2_Missense_Mutation_p.T79P|CD8B_uc002sry.2_Missense_Mutation_p.T79P|CD8B_uc010fgt.2_Missense_Mutation_p.T79P|CD8B_uc002ssa.2_Missense_Mutation_p.T79P|CD8B_uc010yto.1_Missense_Mutation_p.T79P	NM_004931	NP_004922	P10966	CD8B_HUMAN	CD8b antigen isoform 5 precursor	79	Ig-like V-type.|Extracellular (Potential).				immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			upper_aerodigestive_tract(1)|skin(1)	2						CCGTGGATAGTCCCTTTTGCG	0.557			NA											17	65					0	0	0.00499	0	0
THNSL2	55258	broad.mit.edu	37	2	88472698	88472698	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr2:88472698C>T	uc002ssz.3	+	2	182	c.29C>T	c.(28-30)GCC>GTC	p.A10V	THNSL2_uc002ssv.2_Intron|THNSL2_uc002ssw.3_Missense_Mutation_p.A10V|THNSL2_uc002ssx.3_Intron|THNSL2_uc002sta.3_Intron|THNSL2_uc002ssy.3_Missense_Mutation_p.A10V	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	10					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						AGGGGCGTAGCCCCACGGGTC	0.617			NA											8	88					0	0	0.004482	0	0
PLA2R1	22925	broad.mit.edu	37	2	160862239	160862239	+	Silent	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr2:160862239C>T	uc002ube.1	-	11	1965	c.1758G>A	c.(1756-1758)ACG>ACA	p.T586T	PLA2R1_uc010zcp.1_Silent_p.T586T|PLA2R1_uc002ubf.2_Silent_p.T586T	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	586	Extracellular (Potential).|C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TGTATTCTCCCGTATCATTTT	0.458			NA											9	83					0	0	0.004482	0	0
CYYR1	116159	broad.mit.edu	37	21	27840918	27840918	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr21:27840918C>T	uc002ymd.2	-	4	689	c.367G>A	c.(367-369)GAA>AAA	p.E123K	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Missense_Mutation_p.E124K	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	123	Cytoplasmic (Potential).					integral to membrane					0						GCACAGTATTCCATCTCGTGG	0.507			NA											22	55					0	0	0.00278	0	0
PLXNB2	23654	broad.mit.edu	37	22	50721832	50721832	+	Silent	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr22:50721832C>T	uc003bkv.3	-	16	2719	c.2613G>A	c.(2611-2613)GGG>GGA	p.G871G	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	871	Extracellular (Potential).|IPT/TIG 1.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCGACACCCCCCGTGAAAG	0.662			NA											4	27					0	0	0.000248	0	0
CRHBP	1393	broad.mit.edu	37	5	76249905	76249905	+	Missense_Mutation	SNP	G	G	A	rs147365557		TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr5:76249905G>A	uc003ker.2	+	3	507	c.227G>A	c.(226-228)CGG>CAG	p.R76Q	CRHBP_uc010izx.2_Missense_Mutation_p.R76Q	NM_001882	NP_001873	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	76					female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		ACCGCCGACCGGCCGCAGCTG	0.652			NA											4	96					0	0	0.001984	0	0
GFPT2	9945	broad.mit.edu	37	5	179757728	179757728	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr5:179757728G>A	uc003mlw.1	-	6	604	c.506C>T	c.(505-507)ACG>ATG	p.T169M		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	169	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CTCGACCAACGTTGAAAACGT	0.388			NA											8	69					0	0	0.00308	0	0
ZAN	7455	broad.mit.edu	37	7	100391747	100391747	+	Silent	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr7:100391747C>T	uc003uwj.2	+	45	8157	c.7992C>T	c.(7990-7992)GGC>GGT	p.G2664G	ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.G612G	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2664	VWFC 5.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TCTAGCTGGGCAGCAGCTTTC	0.642			NA											5	36					0	0	0.000602	0	0
KIAA0427	9811	broad.mit.edu	37	18	46284770	46284771	+	Frame_Shift_Ins	INS	-	-	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr18:46284770_46284771insC	uc002ldc.2	+	8	1350_1351	c.1065_1066insC	c.(1063-1068)AAGGAAfs	p.K355fs	KIAA0427_uc002ldd.2_Frame_Shift_Ins_p.K355fs|KIAA0427_uc002lde.3_5'Flank	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	355_356					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						GAAGGCTAAAGGAAAAGGTACC	0.515			NA											25	247	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55241679	55241681	+	In_Frame_Del	DEL	AAC	AAC	-			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08	AAC	AAC	-	-	AAC	AAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr7:55241679_55241681delAAC	uc003tqk.2	+	18	2373_2375	c.2127_2129delAAC	c.(2125-2130)GAAACT>GAT	p.709_710ET>D	EGFR_uc010kzg.1_In_Frame_Del_p.664_665ET>D|EGFR_uc011kco.1_In_Frame_Del_p.656_657ET>D	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	709_710	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E709K(17)|p.E709A(11)|p.E709G(7)|p.E709V(5)|p.E709_T710>D(5)|p.E709H(2)|p.E709_T710>G(1)|p.E709_T710>A(1)|p.E709fs*1(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCTTGAAGGAAACTGAATTCAAA	0.567			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			18	58	---	---	---	---	NA	NA	NA	NA	NA