Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTCHD2	57540	broad.mit.edu	37	1	11576212	11576212	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:11576212C>G	uc001ash.3	+	6	1881	c.1743C>G	c.(1741-1743)TTC>TTG	p.F581L	PTCHD2_uc001asi.1_Missense_Mutation_p.F581L	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	581	Helical; (Potential).|SSD.				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CTAACGTCTTCTCCCAGGTGC	0.622			NA											8	57					0	0	0.006214	0	0
USP48	84196	broad.mit.edu	37	1	22032648	22032648	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:22032648G>C	uc001bfb.2	-	18	2482	c.2244C>G	c.(2242-2244)TTC>TTG	p.F748L	USP48_uc001bfa.2_Missense_Mutation_p.F286L|USP48_uc010odq.1_Missense_Mutation_p.F760L|USP48_uc009vqc.2_Missense_Mutation_p.F682L|USP48_uc001bfc.2_Missense_Mutation_p.F748L|USP48_uc001bfd.1_5'Flank	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	748	DUSP 3.				ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		CTTCTACAAAGAACTGAGACA	0.343			NA											3	49					0	0	0.000248	0	0
ZDHHC18	84243	broad.mit.edu	37	1	27159094	27159094	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:27159094G>A	uc001bnb.2	+	2	587	c.492G>A	c.(490-492)CAG>CAA	p.Q164Q	ZDHHC18_uc010ofh.1_Silent_p.Q29Q	NM_032283	NP_115659	Q9NUE0	ZDH18_HUMAN	zinc finger, DHHC-type containing 18	164						integral to membrane	zinc ion binding				0		all_cancers(24;5.82e-22)|all_epithelial(13;9.91e-20)|Colorectal(325;0.000147)|Breast(348;0.000706)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;5.71e-53)|Epithelial(14;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(117;1.53e-29)|Colorectal(126;1.9e-09)|COAD - Colon adenocarcinoma(152;4.2e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000548)|STAD - Stomach adenocarcinoma(196;0.00065)|KIRC - Kidney renal clear cell carcinoma(1967;0.000779)|GBM - Glioblastoma multiforme(114;0.0265)|READ - Rectum adenocarcinoma(331;0.0455)|Lung(427;0.163)|LUSC - Lung squamous cell carcinoma(448;0.237)		TGGAGAAACAGATCGGTGAGG	0.537			NA											7	54					0	0	0.001984	0	0
PTPRU	10076	broad.mit.edu	37	1	29618506	29618506	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:29618506C>T	uc001bru.2	+	16	2584	c.2474C>T	c.(2473-2475)TCC>TTC	p.S825F	PTPRU_uc001brv.2_Missense_Mutation_p.S815F|PTPRU_uc001brw.2_Missense_Mutation_p.S815F|PTPRU_uc009vtq.2_Missense_Mutation_p.S815F|PTPRU_uc009vtr.2_Missense_Mutation_p.S815F	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	825	Mediates interaction with CTNNB1 (By similarity).|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CTGGGCCTGTCCTTCATGGAC	0.632			NA											7	72					0	0	0.006214	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32497185	32497185	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:32497185G>C	uc001bub.2	+	3	674	c.568G>C	c.(568-570)GAG>CAG	p.E190Q	KHDRBS1_uc001bua.1_Intron|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	190	KH.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACTGCAGGAAGAGACTGGTGC	0.393	Ovarian(173;401 1982 12359 31110 42403)		NA											8	97					0	0	0.00308	0	0
MEAF6	64769	broad.mit.edu	37	1	37974889	37974889	+	Silent	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:37974889G>T	uc001cbg.1	-	4	347	c.330C>A	c.(328-330)CTC>CTA	p.L110L	MEAF6_uc001cbd.1_Silent_p.L88L|MEAF6_uc001cbe.1_Silent_p.L110L|MEAF6_uc009vvd.1_RNA|MEAF6_uc001cbf.1_RNA|MEAF6_uc001cbh.1_Silent_p.L110L	NM_022756	NP_073593	Q9HAF1	EAF6_HUMAN	MYST/Esa1-associated factor 6	110					histone H2A acetylation|histone H3-K14 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|NuA4 histone acetyltransferase complex|nucleolus	protein binding				0						TCTTTTCAATGAGCTGGTCCT	0.403			NA											16	101					2.32078e-09	3.49707e-09	0.003163	1	0
GJA9	81025	broad.mit.edu	37	1	39340485	39340485	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:39340485G>C	uc001cct.1	-	2	1567	c.1286C>G	c.(1285-1287)TCT>TGT	p.S429C	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	429	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			ATGTTCTGTAGAGGAACCCCA	0.512			NA											3	63					0	0	0.004672	0	0
MACF1	23499	broad.mit.edu	37	1	39889739	39889739	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:39889739G>A	uc010oiu.1	+	25	11640	c.11509G>A	c.(11509-11511)GAC>AAC	p.D3837N	MACF1_uc010ois.1_Missense_Mutation_p.D3335N|MACF1_uc001cda.1_Missense_Mutation_p.D3222N|MACF1_uc001cdc.1_Missense_Mutation_p.D2401N	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5402	Spectrin 7.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGCCACAGTAGACATGCTTCA	0.448			NA											5	64					0	0	0.001168	0	0
PIK3R3	8503	broad.mit.edu	37	1	46532698	46532698	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:46532698G>A	uc001cpb.3	-	4	1136	c.380C>T	c.(379-381)CCT>CTT	p.P127L	PIK3R3_uc009vyb.2_Missense_Mutation_p.P127L|PIK3R3_uc009vyc.2_Missense_Mutation_p.P144L|PIK3R3_uc001cpc.3_Missense_Mutation_p.P127L|PIK3R3_uc010olw.1_Missense_Mutation_p.P173L	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	127	SH2 1.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					AAATGTCAGAGGATCAGAAAA	0.398			NA											14	123					0	0	0.001855	0	0
CMPK1	51727	broad.mit.edu	37	1	47838678	47838678	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:47838678G>C	uc001cri.2	+	3	519	c.370G>C	c.(370-372)GAT>CAT	p.D124H	CMPK1_uc010omp.1_Missense_Mutation_p.D75H|CMPK1_uc010omq.1_RNA	NM_016308	NP_057392	P30085	KCY_HUMAN	UMP-CMP kinase 1 isoform a	92					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			ovary(1)	1					Gemcitabine(DB00441)	ATTCTTGATTGATGGGTTTCC	0.353			NA											3	42					0	0	0.004672	0	0
LRRC7	57554	broad.mit.edu	37	1	70555443	70555443	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:70555443G>C	uc001dep.2	+	23	4402	c.4372G>C	c.(4372-4374)GGA>CGA	p.G1458R	LRRC7_uc009wbg.2_Missense_Mutation_p.G742R|LRRC7_uc001deq.2_Missense_Mutation_p.G652R	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1458	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCCTGGCCTTGGATTTAGTAT	0.289			NA											5	33					0	0	0.001168	0	0
TNNI3K	51086	broad.mit.edu	37	1	74834796	74834796	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:74834796C>G	uc001dgf.1	+	14	1463	c.1412C>G	c.(1411-1413)TCA>TGA	p.S471*	TNNI3K_uc001dgc.1_Nonsense_Mutation_p.S572*|TNNI3K_uc001dgd.2_Nonsense_Mutation_p.S572*|TNNI3K_uc001dge.1_Nonsense_Mutation_p.S572*	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	471	ATP (By similarity).|Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						ATTATTGGCTCAGGTAACCta	0.333			NA											3	23					0	0	0.004672	0	0
AGL	178	broad.mit.edu	37	1	100358154	100358154	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:100358154C>G	uc001dsi.1	+	24	3650	c.3250C>G	c.(3250-3252)CTA>GTA	p.L1084V	AGL_uc001dsj.1_Missense_Mutation_p.L1084V|AGL_uc001dsk.1_Missense_Mutation_p.L1084V|AGL_uc001dsl.1_Missense_Mutation_p.L1084V|AGL_uc001dsm.1_Missense_Mutation_p.L1068V|AGL_uc001dsn.1_Missense_Mutation_p.L1067V	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1084	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTGTGTTTCTCTAGCTGCAGG	0.343			NA											4	23					0	0	0.000602	0	0
VAV3	10451	broad.mit.edu	37	1	108319902	108319902	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:108319902C>G	uc001dvk.1	-	4	451	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	VAV3_uc010ouw.1_Missense_Mutation_p.E133Q|VAV3_uc001dvl.1_5'UTR|VAV3_uc010oux.1_Missense_Mutation_p.E133Q	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	133					angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTAATGCTTTCTTCTGTTGGG	0.388			NA											7	51					0	0	0.004482	0	0
NBPF10	100132406	broad.mit.edu	37	1	145368669	145368669	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:145368669C>T	uc001end.3	+	86	10907	c.10872C>T	c.(10870-10872)GTC>GTT	p.V3624V	NBPF9_uc010oye.1_Silent_p.V908V|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Silent_p.V477V|NBPF10_uc010oyk.1_Silent_p.V265V|NBPF10_uc010oyl.1_Silent_p.V265V	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3549											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGATGGGAGTCATATTCCCAC	0.448			NA											22	466					0	0	0.008361	0	0
HIST2H2AB	317772	broad.mit.edu	37	1	149859277	149859277	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:149859277G>A	uc001ete.2	-	1	190	c.190C>T	c.(190-192)CTG>TTG	p.L64L	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	64					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GCCAGCTCCAGAATTTCCGCG	0.632			NA											5	67					0	0	0.001168	0	0
PRPF3	9129	broad.mit.edu	37	1	150316917	150316917	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:150316917G>A	uc001eum.3	+	12	1696	c.1534G>A	c.(1534-1536)GAA>AAA	p.E512K	PRPF3_uc009wlp.2_RNA|PRPF3_uc010pca.1_Missense_Mutation_p.E471K|PRPF3_uc010pcb.1_Missense_Mutation_p.E463K|PRPF3_uc009wlq.1_RNA	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	512					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		CAGAGCGCATGAAGAGGCCAA	0.483	Ovarian(168;1070 2670 5178 20729)		NA											8	107					0	0	0.006214	0	0
TCHH	7062	broad.mit.edu	37	1	152081957	152081957	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:152081957C>G	uc001ezp.2	-	2	3736	c.3736G>C	c.(3736-3738)GAG>CAG	p.E1246Q	TCHH_uc009wne.1_Missense_Mutation_p.E1246Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1246					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTTCATTCTCTCTGCCTTTG	0.512			NA											7	87					0	0	0.001984	0	0
CD1E	913	broad.mit.edu	37	1	158324255	158324255	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:158324255C>A	uc001fse.2	+	2	386	c.147C>A	c.(145-147)AGC>AGA	p.S49R	CD1E_uc010pid.1_Missense_Mutation_p.S47R|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.S49R|CD1E_uc001fsk.2_Missense_Mutation_p.S49R|CD1E_uc001fsj.2_Missense_Mutation_p.S49R|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.S49R|CD1E_uc001fry.2_Missense_Mutation_p.S49R|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.S49R|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.S49R|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	49					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					CCAACCACAGCTGGGCACACA	0.582			NA											10	106					9.70103e-10	1.47188e-09	0.008291	1	0
IFI16	3428	broad.mit.edu	37	1	158988382	158988382	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:158988382G>A	uc001ftf.1	+	6	1520	c.913G>A	c.(913-915)GAT>AAT	p.D305N	IFI16_uc001ftg.2_Missense_Mutation_p.D305N|IFI16_uc010pis.1_Missense_Mutation_p.D249N	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	305	HIN-200 1.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TCTGAAGATTGATATTCTTCA	0.353			NA											11	72					0	0	0.001368	0	0
APCS	325	broad.mit.edu	37	1	159558241	159558241	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:159558241C>T	uc001ftv.2	+	2	511	c.415C>T	c.(415-417)CGA>TGA	p.R139*		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	139	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					AAAGGGTCTGCGACAGGGTTA	0.507			NA											6	56					0	0	0.001984	0	0
BLZF1	8548	broad.mit.edu	37	1	169347731	169347731	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:169347731A>C	uc001gfx.1	+	4	1069	c.632A>C	c.(631-633)CAG>CCG	p.Q211P	BLZF1_uc001gfy.2_Missense_Mutation_p.Q211P|BLZF1_uc009wvp.1_Missense_Mutation_p.Q188P	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	211	Potential.				cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					ATGTCAATACAGTGTGATGTA	0.383			NA											24	81					0	0	0.00333	0	0
DNM3	26052	broad.mit.edu	37	1	172011224	172011224	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:172011224C>G	uc001gie.2	+	8	1244	c.1068C>G	c.(1066-1068)CTC>CTG	p.L356L	DNM3_uc001gid.3_Silent_p.L356L|DNM3_uc009wwb.2_Silent_p.L356L|DNM3_uc001gif.2_Silent_p.L356L	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	356					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CCCTGGAACTCTCAGGTGGTG	0.368			NA											9	82					0	0	0.006214	0	0
C1orf9	51430	broad.mit.edu	37	1	172579328	172579328	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:172579328G>C	uc001giq.3	+	24	4010	c.3694G>C	c.(3694-3696)GAC>CAC	p.D1232H	C1orf9_uc009wwd.2_Missense_Mutation_p.D1188H|C1orf9_uc010pmn.1_Missense_Mutation_p.D861H|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	1232					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		GAGCCTGCATGACATAATCAA	0.388	Colon(43;174 953 11768 38880 47057)		NA											9	35					0	0	0.008291	0	0
FASLG	356	broad.mit.edu	37	1	172629280	172629280	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:172629280G>C	uc001gis.2	+	2	551	c.394G>C	c.(394-396)GGC>CGC	p.G132R	FASLG_uc001git.2_Intron	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	132	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						GAAGCAAATAGGTGAGTCTTT	0.358	Ovarian(28;486 876 30334 44033)		NA											3	66					0	0	0.000602	0	0
FAM5B	57795	broad.mit.edu	37	1	177245507	177245507	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:177245507G>C	uc001glf.2	+	6	1261	c.949G>C	c.(949-951)GAG>CAG	p.E317Q	FAM5B_uc010pna.1_Missense_Mutation_p.E67Q|FAM5B_uc001glg.2_Missense_Mutation_p.E212Q	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	317						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CCAGGCCATGGAGGACAGCCT	0.557			NA											3	40					0	0	0.000248	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179820418	179820418	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:179820418C>T	uc001gnk.2	-	4	503	c.115G>A	c.(115-117)GAA>AAA	p.E39K	TOR1AIP2_uc001gnl.2_Missense_Mutation_p.E39K	NM_145034	NP_659471	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	39						endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1						ATCTCAGCTTCTTCAGCATTA	0.413			NA											8	85					0	0	0.00308	0	0
HMCN1	83872	broad.mit.edu	37	1	186086243	186086243	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:186086243C>G	uc001grq.1	+	76	11908	c.11679C>G	c.(11677-11679)GTC>GTG	p.V3893V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3893					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATCTCACTGTCCAAGGTAGAA	0.373			NA											7	70					0	0	0.00308	0	0
ELF3	1999	broad.mit.edu	37	1	201980376	201980376	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:201980376G>C	uc001gxg.3	+	1	3304	c.112G>C	c.(112-114)GAT>CAT	p.D38H	ELF3_uc001gxi.3_Missense_Mutation_p.D38H|ELF3_uc001gxh.3_Missense_Mutation_p.D38H	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	38					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CTTTGGGGCCGATGACTTGGT	0.572			NA											8	90					0	0	0.00308	0	0
MFSD4	148808	broad.mit.edu	37	1	205553109	205553109	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:205553109G>A	uc001hcv.3	+	4	803	c.717G>A	c.(715-717)ATG>ATA	p.M239I	MFSD4_uc010prk.1_Missense_Mutation_p.M152I|MFSD4_uc010prl.1_RNA|MFSD4_uc010prm.1_Missense_Mutation_p.M184I	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	239	Helical; (Potential).				transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CTGTGCTGATGCTGCTGTCCA	0.642			NA											8	61					0	0	0.006214	0	0
FAM71A	149647	broad.mit.edu	37	1	212799595	212799595	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:212799595C>T	uc001hjk.2	+	1	1780	c.1376C>T	c.(1375-1377)TCC>TTC	p.S459F	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	459										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CAAAAGTCCTCCAGCAGGTCC	0.552			NA											6	53					0	0	0.001168	0	0
RYR2	6262	broad.mit.edu	37	1	237777351	237777351	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:237777351C>T	uc001hyl.1	+	37	5043	c.4923C>T	c.(4921-4923)ATC>ATT	p.I1641I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1641	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGTTGACATCTTAGAGTTGA	0.438			NA											5	49					0	0	0.000602	0	0
ZP4	57829	broad.mit.edu	37	1	238046082	238046082	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:238046082C>T	uc001hym.2	-	11	1455	c.1455G>A	c.(1453-1455)ATG>ATA	p.M485I	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	485	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGAGTAGAATCATGGGGCCTT	0.393	NSCLC(166;160 2029 11600 18754 19936)		NA											13	65					0	0	0.003163	0	0
OR2T34	127068	broad.mit.edu	37	1	248737462	248737462	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:248737462G>A	uc001iep.1	-	1	597	c.597C>T	c.(595-597)CTC>CTT	p.L199L		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCATCTTATAGAGGGAGACGT	0.512			NA											22	275					0	0	0.004656	0	0
TMEM26	219623	broad.mit.edu	37	10	63212759	63212759	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr10:63212759C>G	uc001jlo.2	-	1	450	c.81G>C	c.(79-81)GTG>GTC	p.V27V	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlq.2_RNA|uc001jlr.2_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	27						integral to membrane					0	Prostate(12;0.0112)					TCACCTCGGTCACTCGCCAGA	0.632			NA											18	114					0	0	0.008871	0	0
SORCS1	114815	broad.mit.edu	37	10	108466321	108466321	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr10:108466321C>G	uc001kym.2	-	8	1223	c.1215G>C	c.(1213-1215)CCG>CCC	p.P405P	SORCS1_uc001kyl.2_Silent_p.P405P|SORCS1_uc009xxs.2_Silent_p.P405P|SORCS1_uc001kyn.1_Silent_p.P405P|SORCS1_uc001kyo.2_Silent_p.P405P	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	405	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAGCATATTTCGGAAGCTTCA	0.458			NA											5	55					0	0	0.001168	0	0
C10orf120	399814	broad.mit.edu	37	10	124457724	124457724	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr10:124457724C>A	uc001lgn.2	-	3	565	c.533G>T	c.(532-534)GGA>GTA	p.G178V		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	178										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				CTGATGATTTCCCAGAGCCCG	0.507			NA											17	104					1.96292e-10	2.98853e-10	0.001523	1	0
MUC5B	727897	broad.mit.edu	37	11	1275512	1275512	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:1275512C>G	uc009ycr.1	+	56	16545	c.16419C>G	c.(16417-16419)CTC>CTG	p.L5473L	MUC5B_uc001ltb.2_Silent_p.L5139L	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5136	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCGCGCCCTCAGCATCCACT	0.622			NA											4	47					0	0	0.000248	0	0
TRIM68	55128	broad.mit.edu	37	11	4621894	4621894	+	Missense_Mutation	SNP	C	C	T	rs139399398		TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:4621894C>T	uc001lzf.1	-	7	1308	c.1070G>A	c.(1069-1071)CGG>CAG	p.R357Q	TRIM68_uc001lzg.1_Missense_Mutation_p.R134Q|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	357	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCAGTAGTGCCGGCCTGAGGA	0.542			NA											9	49					0	0	0.004482	0	0
OR51S1	119692	broad.mit.edu	37	11	4869844	4869844	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:4869844C>T	uc010qyo.1	-	1	595	c.595G>A	c.(595-597)GAA>AAA	p.E199K		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCCAAGCTTCTGGGCAGGCC	0.542			NA											10	99					0	0	0.008291	0	0
OR51M1	390059	broad.mit.edu	37	11	5411219	5411219	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:5411219A>G	uc010qzc.1	+	1	591	c.591A>G	c.(589-591)ATA>ATG	p.I197M	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	197						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGAAGTGATACAGCTGGCCT	0.507			NA											11	136					0	0	0.000978	0	0
OR52L1	338751	broad.mit.edu	37	11	6007326	6007326	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:6007326T>A	uc001mcd.2	-	1	890	c.835A>T	c.(835-837)ACT>TCT	p.T279S		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	279	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGCGGTGAGTGAGGAAGGAG	0.502	Melanoma(121;653 1666 10547 22796 51255)		NA											10	59					0	0	0.008291	0	0
USP47	55031	broad.mit.edu	37	11	11972026	11972026	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:11972026G>C	uc001mjs.2	+	24	4343	c.3580G>C	c.(3580-3582)GAT>CAT	p.D1194H	USP47_uc001mjr.2_Missense_Mutation_p.D1126H|USP47_uc009ygi.2_5'UTR	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1214					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TGAAGTTCTTGATGGTATTTT	0.318			NA											7	73					0	0	0.004482	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956268	18956268	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:18956268G>C	uc001mpg.2	-	1	282	c.64C>G	c.(64-66)CTT>GTT	p.L22V		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	22	Extracellular (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						TTGTAGCAAAGAGTCTCCTCA	0.542			NA											21	572					0	0	0.00278	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136376	40136376	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:40136376C>T	uc001mxa.1	-	2	3431	c.1467G>A	c.(1465-1467)GTG>GTA	p.V489V	LRRC4C_uc001mxc.1_Silent_p.V485V|LRRC4C_uc001mxd.1_Silent_p.V485V|LRRC4C_uc001mxb.1_Silent_p.V485V	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	489					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GAGAGGTGGTCACATTGGTGG	0.522			NA											11	38					0	0	0.008291	0	0
CKAP5	9793	broad.mit.edu	37	11	46819519	46819519	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:46819519T>C	uc001ndi.1	-	11	1284	c.1174A>G	c.(1174-1176)ACC>GCC	p.T392A	CKAP5_uc009ylg.1_Missense_Mutation_p.T278A|CKAP5_uc001ndj.1_Missense_Mutation_p.T392A	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	392	HEAT 2.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TGTAGTGTGGTCTTTAGAAAG	0.303	Ovarian(4;85 273 2202 4844 13323)		NA											11	63					0	0	0.001368	0	0
FOLH1	2346	broad.mit.edu	37	11	49207299	49207299	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:49207299C>A	uc001ngy.2	-	6	1009	c.748G>T	c.(748-750)GGA>TGA	p.G250*	FOLH1_uc001ngz.2_Nonsense_Mutation_p.G250*|FOLH1_uc009yly.2_Nonsense_Mutation_p.G235*|FOLH1_uc009ylz.2_Nonsense_Mutation_p.G235*|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	250	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ACACCACCTCCAGGAAGATTC	0.512			NA											10	53					1.76689e-08	2.65336e-08	0.006214	1	0
OR4C15	81309	broad.mit.edu	37	11	55322305	55322305	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:55322305C>A	uc010rig.1	+	1	523	c.523C>A	c.(523-525)CGT>AGT	p.R175S		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGCCTATGATCGTTATGTGGC	0.507			NA								HNSCC(20;0.049)			21	94					1.50039e-11	2.30829e-11	0.001882	1	0
OR4D6	219983	broad.mit.edu	37	11	59224838	59224838	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:59224838G>A	uc010rku.1	+	1	405	c.405G>A	c.(403-405)ATG>ATA	p.M135I		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGTGACCATGATGAGGAAAG	0.488			NA											19	181					0	0	0.008871	0	0
OR4D11	219986	broad.mit.edu	37	11	59271749	59271749	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:59271749G>T	uc001noa.1	+	1	701	c.701G>T	c.(700-702)AGG>ATG	p.R234M		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGGGGCAGGAGGAAAGCCATC	0.557			NA											25	173					1.36565e-18	2.13838e-18	0.00278	1	0
AHNAK	79026	broad.mit.edu	37	11	62289822	62289822	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:62289822G>C	uc001ntl.2	-	5	12367	c.12067C>G	c.(12067-12069)CTG>GTG	p.L4023V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4023					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATCTTAGGCAGAGAAACATCC	0.493			NA											35	238					0	0	0.002836	0	0
UBXN1	51035	broad.mit.edu	37	11	62445299	62445299	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:62445299C>G	uc001nul.1	-	6	620	c.488G>C	c.(487-489)AGA>ACA	p.R163T	UBXN1_uc001nuj.2_Missense_Mutation_p.R163T|UBXN1_uc001num.1_Missense_Mutation_p.R159T|UBXN1_uc001nuk.2_Missense_Mutation_p.R128T|UBXN1_uc010rme.1_Missense_Mutation_p.R163T	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	163	Potential.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						TTCTCTAACTCTTTGTCTGAA	0.438			NA											10	75					0	0	0.006214	0	0
UBXN1	51035	broad.mit.edu	37	11	62445457	62445457	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:62445457C>T	uc001nul.1	-	5	556	c.424G>A	c.(424-426)GAG>AAG	p.E142K	UBXN1_uc001nuj.2_Missense_Mutation_p.E142K|UBXN1_uc001num.1_Missense_Mutation_p.E142K|UBXN1_uc001nuk.2_Missense_Mutation_p.E107K|UBXN1_uc010rme.1_Missense_Mutation_p.E142K|UBXN1_uc010rmf.1_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	142	Potential.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						CGGCGCATCTCATCTTCCTGT	0.577			NA											7	33					0	0	0.001984	0	0
TMEM179B	374395	broad.mit.edu	37	11	62556550	62556550	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:62556550C>T	uc001nvd.3	+	2	182	c.152C>T	c.(151-153)TCC>TTC	p.S51F		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	51						integral to membrane					0						AATGGCTCCTCCCTGGCCTTA	0.567			NA											13	116					0	0	0.001368	0	0
STIP1	10963	broad.mit.edu	37	11	63971032	63971032	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:63971032G>C	uc001nyk.1	+	13	1644	c.1497G>C	c.(1495-1497)ATG>ATC	p.M499I	STIP1_uc010rnb.1_Missense_Mutation_p.M475I	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	499	STI1 2.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						AGCAGATCATGAGTGACCCAG	0.597			NA											5	42					0	0	0.000602	0	0
RBM4	5936	broad.mit.edu	37	11	66407528	66407528	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:66407528G>C	uc009yrj.2	+	2	834	c.346G>C	c.(346-348)GTA>CTA	p.V116L	RBM4_uc009yrk.2_Intron|RBM4_uc001oiv.2_Missense_Mutation_p.V116L|RBM4_uc001oiw.1_Missense_Mutation_p.V116L|RBM4_uc001oix.1_Missense_Mutation_p.V116L|RBM4_uc010rpj.1_Missense_Mutation_p.V116L|RBM4_uc001oiy.1_Missense_Mutation_p.V116L|RBM4_uc001oiz.1_Missense_Mutation_p.V116L	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	116	RRM 2.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		TTATGCCTTCGTACACATGGA	0.527			NA											12	109					0	0	0.00245	0	0
NUMA1	4926	broad.mit.edu	37	11	71717294	71717294	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:71717294C>G	uc001orl.1	-	22	5651	c.5479G>C	c.(5479-5481)GAG>CAG	p.E1827Q	NUMA1_uc001orj.2_Missense_Mutation_p.E9Q|NUMA1_uc009ysw.1_Missense_Mutation_p.E1394Q|NUMA1_uc001ork.1_Missense_Mutation_p.E691Q|NUMA1_uc001orm.1_Missense_Mutation_p.E1813Q	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1827					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTGTCTGGCTCTTCCACATCT	0.562			NA	T	RARA	APL								5	45					0	0	0.000602	0	0
GRM5	2915	broad.mit.edu	37	11	88780521	88780521	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:88780521C>T	uc001pcq.2	-	1	720	c.520G>A	c.(520-522)GCA>ACA	p.A174T	GRM5_uc009yvm.2_Missense_Mutation_p.A174T|GRM5_uc009yvn.1_Missense_Mutation_p.A174T	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	174	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ATGCTGGTTGCTGAGTAAGCA	0.488			NA											7	63					0	0	0.001984	0	0
TMEM133	83935	broad.mit.edu	37	11	100863119	100863119	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:100863119G>T	uc001pgf.2	+	1	309	c.80G>T	c.(79-81)TGT>TTT	p.C27F		NM_032021	NP_114410	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	27						integral to membrane					0		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		CTTGACTATTGTCCAGAAGTT	0.438			NA											23	77					3.5997e-14	5.59671e-14	0.002299	1	0
APOA4	337	broad.mit.edu	37	11	116693391	116693391	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:116693391G>A	uc001pps.1	-	2	264	c.160C>T	c.(160-162)CTC>TTC	p.L54F		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		TGCTGGGTGAGTTCAGATTTC	0.428			NA											28	287					0	0	0.008361	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120291464	120291464	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:120291464C>G	uc001pxl.1	+	5	209	c.202C>G	c.(202-204)CTT>GTT	p.L68V	ARHGEF12_uc009zat.2_Missense_Mutation_p.L49V|ARHGEF12_uc010rzn.1_5'UTR|ARHGEF12_uc009zau.1_5'UTR	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	68					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TTGTGCAGGTCTTGTTCAGCG	0.403			NA	T	MLL	AML								4	34					0	0	0.000248	0	0
HEPN1	641654	broad.mit.edu	37	11	124789818	124789818	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:124789818G>C	uc001qbj.1	+	1	673	c.172G>C	c.(172-174)GAT>CAT	p.D58H	HEPACAM_uc009zbj.2_3'UTR|HEPACAM_uc001qbk.2_3'UTR	NM_001037558	NP_001032647	Q6WQI6	HEPN1_HUMAN	HEPACAM opposite strand 1	58						cytoplasm					0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		TCACACAGTAGATTACTGCCA	0.493			NA											7	82					0	0	0.001984	0	0
KIRREL3	84623	broad.mit.edu	37	11	126306811	126306811	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:126306811G>C	uc001qea.2	-	12	1808	c.1447C>G	c.(1447-1449)CTG>GTG	p.L483V	KIRREL3_uc001qeb.2_Missense_Mutation_p.L483V|KIRREL3_uc001qec.1_Missense_Mutation_p.L483V|ST3GAL4_uc001qdx.1_Intron	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	483	Extracellular (Potential).|Ig-like C2-type 5.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CTGATGGTCAGGGTGGAGATG	0.617			NA											4	33					0	0	0.000248	0	0
ERC1	23085	broad.mit.edu	37	12	1221420	1221420	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:1221420C>G	uc001qjb.2	+	6	1598	c.1357C>G	c.(1357-1359)CAA>GAA	p.Q453E	ERC1_uc001qiz.2_Intron|ERC1_uc001qjc.2_Intron|ERC1_uc001qja.2_Intron|ERC1_uc001qjd.2_Intron|ERC1_uc001qjf.2_Missense_Mutation_p.Q453E|ERC1_uc010sdv.1_Intron|ERC1_uc009zdp.2_Missense_Mutation_p.Q90E	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	453	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GAAAGAGGCTCAATGGGAGGA	0.458			NA											12	124					0	0	0.00245	0	0
GSG1	83445	broad.mit.edu	37	12	13240941	13240941	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:13240941G>A	uc001rbn.2	-	5	707	c.534C>T	c.(532-534)TTC>TTT	p.F178F	GSG1_uc001rbj.2_Silent_p.F142F|GSG1_uc001rbk.2_Missense_Mutation_p.H184Y|GSG1_uc001rbl.2_Intron|GSG1_uc001rbm.2_Intron|GSG1_uc001rbo.2_Missense_Mutation_p.H220Y|GSG1_uc001rbp.2_Silent_p.F155F|GSG1_uc001rbq.1_Missense_Mutation_p.H220Y	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	165	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GGAAGCTGATGAATTGAAGTC	0.512			NA											16	113					0	0	0.006122	0	0
CASC1	55259	broad.mit.edu	37	12	25272230	25272230	+	Silent	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:25272230G>C	uc001rgl.2	-	11	1309	c.1227C>G	c.(1225-1227)CTC>CTG	p.L409L	CASC1_uc001rgk.2_Silent_p.L415L|CASC1_uc001rgm.3_Silent_p.L473L|CASC1_uc001rgj.2_Silent_p.L369L|CASC1_uc010sje.1_Silent_p.L350L|CASC1_uc010sjf.1_Silent_p.L297L|CASC1_uc010sjg.1_Silent_p.L409L	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	409										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			ATCCTTCTTTGAGTATCTTTT	0.323			NA											5	71					0	0	0.000602	0	0
AAAS	8086	broad.mit.edu	37	12	53709147	53709147	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:53709147A>G	uc001scr.3	-	4	534	c.371T>C	c.(370-372)CTC>CCC	p.L124P	AAAS_uc001scs.3_Missense_Mutation_p.L124P	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	124					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						GGACCCATGGAGGGAAGAGGC	0.562			NA											4	25					0	0	0.001168	0	0
OR6C6	283365	broad.mit.edu	37	12	55688558	55688558	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:55688558G>A	uc010sph.1	-	1	459	c.459C>T	c.(457-459)ATC>ATT	p.I153I		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						GGGGAAATATGATTAAGAATC	0.418			NA											6	46					0	0	0.001168	0	0
ATP5B	506	broad.mit.edu	37	12	57032983	57032983	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:57032983G>C	uc001slr.2	-	9	1501	c.1396C>G	c.(1396-1398)CAG>GAG	p.Q466E	BAZ2A_uc001slq.1_5'Flank|BAZ2A_uc010sqr.1_5'Flank	NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	466					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						TGGAATGGCTGAGACAAGAAA	0.498			NA											15	156					0	0	0.003163	0	0
ATP5B	506	broad.mit.edu	37	12	57036523	57036523	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:57036523G>A	uc001slr.2	-	6	990	c.885C>T	c.(883-885)GAC>GAT	p.D295D		NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	295					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						GACCTTCTTGGTCTCTGAAGT	0.498			NA											11	84					0	0	0.008291	0	0
BEST3	144453	broad.mit.edu	37	12	70049076	70049076	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:70049076C>T	uc001svg.2	-	10	1845	c.1618G>A	c.(1618-1620)GAG>AAG	p.E540K	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.E327K|BEST3_uc010stm.1_Missense_Mutation_p.E434K	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	540	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TGCTGCTGCTCAGTCTTGCTT	0.597			NA											11	424					0	0	0.001855	0	0
BEST3	144453	broad.mit.edu	37	12	70065208	70065208	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:70065208C>T	uc001svg.2	-	9	1327	c.1100G>A	c.(1099-1101)GGG>GAG	p.G367E	BEST3_uc001svd.1_Missense_Mutation_p.G367E|BEST3_uc001sve.1_RNA|BEST3_uc001svf.2_Missense_Mutation_p.G154E|BEST3_uc010stm.1_Missense_Mutation_p.G261E|BEST3_uc001svh.2_Missense_Mutation_p.G154E	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	367	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			ATGCACTTACCCCATCTGGAC	0.294			NA											10	150					0	0	0.001368	0	0
PTPRB	5787	broad.mit.edu	37	12	71002895	71002895	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:71002895G>A	uc001swb.3	-	2	309	c.279C>T	c.(277-279)TTC>TTT	p.F93F	PTPRB_uc010sto.1_Silent_p.F93F|PTPRB_uc010stp.1_Silent_p.F93F|PTPRB_uc001swc.3_Silent_p.F311F|PTPRB_uc001swa.3_Silent_p.F311F|PTPRB_uc001swd.3_Silent_p.F310F|PTPRB_uc009zrr.1_Silent_p.F190F|PTPRB_uc001swe.2_Silent_p.F311F	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	93	Fibronectin type-III 1.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AAATAATCCTGAAGTTATAGA	0.502			NA											7	255					0	0	0.00308	0	0
PTPRR	5801	broad.mit.edu	37	12	71139815	71139815	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:71139815C>G	uc001swi.1	-	6	1206	c.790G>C	c.(790-792)GAG>CAG	p.E264Q	PTPRR_uc001swh.1_Missense_Mutation_p.E19Q|PTPRR_uc009zrs.2_Missense_Mutation_p.E113Q|PTPRR_uc010stq.1_Missense_Mutation_p.E152Q|PTPRR_uc010str.1_Missense_Mutation_p.E113Q	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	264	Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TGGTTTTTCTCTTTGTCTTGT	0.423			NA											5	115					0	0	0.001168	0	0
TRHDE	29953	broad.mit.edu	37	12	73046174	73046174	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:73046174C>G	uc001sxa.2	+	16	2643	c.2613C>G	c.(2611-2613)TTC>TTG	p.F871L		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	871	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TCTGGGAATTCATATGGATGA	0.388			NA											6	83					0	0	0.001168	0	0
NAV3	89795	broad.mit.edu	37	12	78444604	78444604	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:78444604C>T	uc001syp.2	+	11	2366	c.2193C>T	c.(2191-2193)CCC>CCT	p.P731P	NAV3_uc001syo.2_Silent_p.P731P|NAV3_uc010sub.1_Silent_p.P231P	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	731						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GGACCATACCCAACTTGACAA	0.522			NA								HNSCC(70;0.22)			6	72					0	0	0.001984	0	0
TRPV4	59341	broad.mit.edu	37	12	110232288	110232288	+	Missense_Mutation	SNP	C	C	A	rs143502097	byFrequency	TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:110232288C>A	uc001tpj.1	-	7	1432	c.1337G>T	c.(1336-1338)CGC>CTC	p.R446L	TRPV4_uc001tpg.1_Missense_Mutation_p.R412L|TRPV4_uc001tph.1_Missense_Mutation_p.R399L|TRPV4_uc001tpi.1_Missense_Mutation_p.R339L|TRPV4_uc001tpk.1_Missense_Mutation_p.R446L|TRPV4_uc001tpl.1_Missense_Mutation_p.R386L	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	446	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CATCTCGTGGCGGTTCTAAGA	0.647			NA											11	93					1.61879e-10	2.47315e-10	0.001368	1	0
MAPKAPK5	8550	broad.mit.edu	37	12	112323825	112323825	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:112323825G>T	uc001tta.2	+	10	1213	c.954G>T	c.(952-954)CAG>CAT	p.Q318H	MAPKAPK5_uc001tsz.2_Missense_Mutation_p.Q318H|MAPKAPK5_uc001ttb.2_Missense_Mutation_p.Q251H	NM_139078	NP_620777	Q8IW41	MAPK5_HUMAN	MAP kinase-activated protein kinase 5 isoform 2	318					signal transduction	cytoplasm|nucleus	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)	3						CTTCTGCTCAGCTGATGATGG	0.527			NA											11	93					1.58986e-06	2.36331e-06	0.008291	1	0
KDM2B	84678	broad.mit.edu	37	12	121890993	121890993	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:121890993C>T	uc001uat.2	-	13	1993	c.1889G>A	c.(1888-1890)TGC>TAC	p.C630Y	KDM2B_uc001uaq.2_Missense_Mutation_p.C70Y|KDM2B_uc010szy.1_Missense_Mutation_p.C70Y|KDM2B_uc001uar.2_Missense_Mutation_p.C221Y|KDM2B_uc001uas.2_Missense_Mutation_p.C599Y|KDM2B_uc001uau.2_Missense_Mutation_p.C513Y	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	630	CXXC-type.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CATGTCCTTGCAGAAGTGGCA	0.697			NA											4	40					0	0	0.000248	0	0
VPS33A	65082	broad.mit.edu	37	12	122729173	122729173	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:122729173G>T	uc001ucd.2	-	7	1025	c.912C>A	c.(910-912)TTC>TTA	p.F304L	VPS33A_uc001ucc.2_RNA	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	304					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CAACTGCGTTGAAGTTCTTAT	0.507			NA											16	64					1.3612e-06	2.03027e-06	0.003163	1	0
FLT1	2321	broad.mit.edu	37	13	28885795	28885795	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr13:28885795G>A	uc001usb.3	-	27	3852	c.3567C>T	c.(3565-3567)TTC>TTT	p.F1189F	FLT1_uc010aap.2_Silent_p.F194F|FLT1_uc010aaq.2_Silent_p.F314F|FLT1_uc001usa.3_Silent_p.F407F	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1189	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGTCCTCAGAGAAGGCAGGAG	0.398			NA											6	28					0	0	0.001168	0	0
STARD13	90627	broad.mit.edu	37	13	33700248	33700248	+	Silent	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr13:33700248C>A	uc001uuw.2	-	7	2178	c.2052G>T	c.(2050-2052)CTG>CTT	p.L684L	STARD13_uc001uuu.2_Silent_p.L676L|STARD13_uc001uuv.2_Silent_p.L566L|STARD13_uc001uux.2_Silent_p.L649L|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	684	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GTAGATATCTCAGTGCTTGCT	0.552			NA											12	84					0.000151284	0.000218246	0.001855	1	0
TRPC4	7223	broad.mit.edu	37	13	38237715	38237715	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr13:38237715A>G	uc001uws.2	-	6	1761	c.1526T>C	c.(1525-1527)CTG>CCG	p.L509P	TRPC4_uc010abv.2_Missense_Mutation_p.L89P|TRPC4_uc001uwt.2_Missense_Mutation_p.L509P|TRPC4_uc010tey.1_Missense_Mutation_p.L509P|TRPC4_uc010abw.2_Missense_Mutation_p.L336P|TRPC4_uc010abx.2_Missense_Mutation_p.L509P|TRPC4_uc010aby.2_Missense_Mutation_p.L509P	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	509	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CATTCTTCCCAGAGATATTTG	0.398			NA											13	31					0	0	0.001855	0	0
LMO7	4008	broad.mit.edu	37	13	76395416	76395416	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr13:76395416G>C	uc001vjv.2	+	11	2372	c.1612G>C	c.(1612-1614)GAA>CAA	p.E538Q	LMO7_uc010thv.1_Missense_Mutation_p.E489Q|LMO7_uc001vjt.1_Missense_Mutation_p.E437Q|LMO7_uc010thw.1_Missense_Mutation_p.E388Q|LMO7_uc001vjw.1_Missense_Mutation_p.E444Q	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	823						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GACTGTGTCAGAAGCAAGTTA	0.428			NA											6	50					0	0	0.001168	0	0
ACIN1	22985	broad.mit.edu	37	14	23532787	23532787	+	Splice_Site	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr14:23532787C>G	uc001wit.3	-	13	3098	c.2770_splice	c.e13-1	p.V924_splice	ACIN1_uc001wio.3_Splice_Site|ACIN1_uc001wip.3_Splice_Site_p.V166_splice|ACIN1_uc001wiq.3_Splice_Site_p.V166_splice|ACIN1_uc001wir.3_Splice_Site_p.V197_splice|ACIN1_uc001wis.3_Splice_Site_p.V605_splice|ACIN1_uc010akg.2_Splice_Site_p.V911_splice	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1						apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CAGGTACTACCTATCAAGGTG	0.502			NA											9	79					0	0	0.004482	0	0
RPAP1	26015	broad.mit.edu	37	15	41810036	41810036	+	Missense_Mutation	SNP	C	C	T	rs147536655		TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr15:41810036C>T	uc001zod.2	-	24	4116	c.3992G>A	c.(3991-3993)CGC>CAC	p.R1331H	RPAP1_uc001zoc.2_Missense_Mutation_p.R350H	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1331						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CATACTCCTGCGGGCAGCTTT	0.567			NA											39	266					0	0	0.006999	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49301449	49301449	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr15:49301449G>T	uc001zxe.1	-	14	2125	c.1991C>A	c.(1990-1992)TCA>TAA	p.S664*	SECISBP2L_uc001zxd.1_Nonsense_Mutation_p.S619*|SECISBP2L_uc010bep.1_Nonsense_Mutation_p.S426*	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	664										breast(1)|skin(1)	2						GGTTATTGTTGAAGATGCCAT	0.383			NA											10	86					3.86212e-05	5.58991e-05	0.008291	1	0
HEXA	3073	broad.mit.edu	37	15	72668262	72668262	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr15:72668262C>G	uc002aun.3	-	1	259	c.52G>C	c.(52-54)GGA>CGA	p.G18R	CELF6_uc002auk.3_RNA|HEXA_uc010ukn.1_Missense_Mutation_p.G18R|HEXA_uc002auo.3_5'UTR|HEXA_uc010bix.2_Missense_Mutation_p.G18R|HEXA_uc010biy.2_5'UTR|HEXA_uc010uko.1_5'UTR|HEXA_uc010biz.1_RNA|C15orf34_uc010ukp.1_5'Flank	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	18					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						GTCGCCCGTCCTGCGAACGCT	0.627			NA											14	115					0	0	0.001855	0	0
UBE2Q2	92912	broad.mit.edu	37	15	76165798	76165798	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr15:76165798G>A	uc002bbg.2	+	5	863	c.477G>A	c.(475-477)ATG>ATA	p.M159I	UBE2Q2_uc002bbh.2_Missense_Mutation_p.M124I|UBE2Q2_uc010umn.1_Missense_Mutation_p.M143I|UBE2Q2_uc002bbi.2_Missense_Mutation_p.M40I	NM_173469	NP_775740	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q 2 isoform 1	159	Glu-rich.				protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			ovary(2)	2						ACTATGAGATGAAGGAAGAAG	0.333			NA											4	28					0	0	0.000248	0	0
NARFL	64428	broad.mit.edu	37	16	784253	784253	+	Silent	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:784253G>C	uc002cjr.2	-	6	681	c.669C>G	c.(667-669)GTC>GTG	p.V223V	NARFL_uc002cjp.2_Silent_p.V121V|NARFL_uc002cjq.2_Silent_p.V121V|NARFL_uc002cjs.2_Silent_p.V5V|NARFL_uc010brc.1_3'UTR|NARFL_uc010uur.1_Nonsense_Mutation_p.S179*|NARFL_uc010uuq.1_5'Flank	NM_022493	NP_071938	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	223					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding				0		Hepatocellular(780;0.0218)				AGAAGTCCTTGACCAGGGAGC	0.642			NA											7	68					0	0	0.001984	0	0
C16orf62	57020	broad.mit.edu	37	16	19663357	19663357	+	Silent	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:19663357C>A	uc002dgn.1	+	26	2178	c.2166C>A	c.(2164-2166)CTC>CTA	p.L722L	C16orf62_uc002dgo.1_Silent_p.L629L|C16orf62_uc002dgp.1_Silent_p.L471L	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	722						integral to membrane				ovary(1)	1						TCACACGTCTCAATCTCTACC	0.547			NA											5	20					3.59834e-05	5.22531e-05	0.001168	1	0
DNAH3	55567	broad.mit.edu	37	16	20975656	20975656	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:20975656C>T	uc010vbe.1	-	53	9550	c.9550G>A	c.(9550-9552)GAA>AAA	p.E3184K	DNAH3_uc010vbd.1_Missense_Mutation_p.E619K	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3184	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACGGCAACTTCTGGGAGGTAA	0.478			NA											8	80					0	0	0.00308	0	0
CDR2	1039	broad.mit.edu	37	16	22358615	22358615	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:22358615G>C	uc002dkn.2	-	5	1344	c.1036C>G	c.(1036-1038)CTG>GTG	p.L346V		NM_001802	NP_001793	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2	346	Potential.					nucleus	protein binding			skin(1)	1				GBM - Glioblastoma multiforme(48;0.0188)		ACTTCGTGCAGAAGGGAGATG	0.567			NA											8	60					0	0	0.004482	0	0
CDR2	1039	broad.mit.edu	37	16	22358863	22358863	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:22358863G>C	uc002dkn.2	-	5	1096	c.788C>G	c.(787-789)TCA>TGA	p.S263*		NM_001802	NP_001793	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2	263	Potential.					nucleus	protein binding			skin(1)	1				GBM - Glioblastoma multiforme(48;0.0188)		TGGATGCTCTGACTGCAACAT	0.562			NA											5	88					0	0	0.001984	0	0
RBBP6	5930	broad.mit.edu	37	16	24573246	24573246	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:24573246G>A	uc002dmh.2	+	10	2093	c.1053G>A	c.(1051-1053)CAG>CAA	p.Q351Q	RBBP6_uc010vcb.1_Silent_p.Q218Q|RBBP6_uc002dmi.2_Silent_p.Q351Q|RBBP6_uc010bxr.2_Silent_p.Q351Q|RBBP6_uc002dmk.2_Silent_p.Q218Q	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	351					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		CACTGATTCAGAGGAACCTAC	0.428			NA											4	58					0	0	0.000248	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147138	26147138	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:26147138C>A	uc002dof.2	+	2	1332	c.940C>A	c.(940-942)CTG>ATG	p.L314M		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	314	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		CTTTGAGGTGCTGGCCTTCAA	0.527			NA											26	205					8.24728e-16	1.28681e-15	0.004656	1	0
ZNF688	146542	broad.mit.edu	37	16	30582364	30582364	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:30582364C>T	uc002dyt.2	-	2	1055	c.277G>A	c.(277-279)GAG>AAG	p.E93K	ZNF688_uc002dys.2_Missense_Mutation_p.E79K|uc002dyu.2_5'Flank	NM_145271	NP_660314	P0C7X2	ZN688_HUMAN	zinc finger protein 688 isoform a	93	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCCCCTTCTCAGGATCCTGG	0.592			NA											5	30					0	0	0.001168	0	0
ZNF688	146542	broad.mit.edu	37	16	30582410	30582410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:30582410C>T	uc002dyt.2	-	2	1009	c.231G>A	c.(229-231)TGG>TGA	p.W77*	ZNF688_uc002dys.2_Nonsense_Mutation_p.W63*|uc002dyu.2_5'Flank	NM_145271	NP_660314	P0C7X2	ZN688_HUMAN	zinc finger protein 688 isoform a	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTGTTCCATCCAAGAGATGA	0.632			NA											5	22					0	0	0.001168	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31484844	31484844	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:31484844C>T	uc002ecd.1	+	2	122	c.96C>T	c.(94-96)CTC>CTT	p.L32L	TGFB1I1_uc002ece.1_Silent_p.L15L|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	32	Transcription activation (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						CGGAGCCTCTCACCCCTCCCC	0.642			NA											9	59					0	0	0.004482	0	0
RBL2	5934	broad.mit.edu	37	16	53504409	53504409	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:53504409G>C	uc002ehi.3	+	16	2478	c.2360G>C	c.(2359-2361)GGA>GCA	p.G787A	RBL2_uc002ehj.2_Missense_Mutation_p.G497A|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	787	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GCCCTGGCTGGAAGTCTGAGC	0.552			NA											7	67					0	0	0.00308	0	0
MT1X	4501	broad.mit.edu	37	16	56716476	56716476	+	Silent	SNP	G	G	A	rs147291148		TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:56716476G>A	uc002ejy.2	+	1	95	c.24G>A	c.(22-24)TCG>TCA	p.S8S	MT1X_uc002ejz.2_RNA	NM_005952	NP_005943	P80297	MT1X_HUMAN	metallothionein 1X	8	Beta.				response to metal ion		metal ion binding				0						GCTCCTGCTCGCCTGGTAAGG	0.557			NA											20	161					0	0	0.001523	0	0
ARL2BP	23568	broad.mit.edu	37	16	57286145	57286145	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:57286145C>T	uc002elf.1	+	6	700	c.458C>T	c.(457-459)TCT>TTT	p.S153F	ARL2BP_uc010vhl.1_Intron	NM_012106	NP_036238	Q9Y2Y0	AR2BP_HUMAN	binder of Arl Two	153					maintenance of protein location in nucleus|positive regulation of tyrosine phosphorylation of Stat3 protein|signal transduction	centrosome|midbody|mitochondrial intermembrane space|nucleus|spindle	protein binding|small GTPase regulator activity|transcription coactivator activity				0						AAATCATCTTCTCTGCCAGCT	0.478			NA											4	68					0	0	0.000602	0	0
GPR56	9289	broad.mit.edu	37	16	57689439	57689439	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:57689439C>T	uc002emb.2	+	7	1189	c.897C>T	c.(895-897)TTC>TTT	p.F299F	GPR56_uc002elz.1_Silent_p.F129F|GPR56_uc002ema.1_Silent_p.F124F|GPR56_uc002emc.2_Silent_p.F299F|GPR56_uc002emf.2_Silent_p.F299F|GPR56_uc010vhs.1_Silent_p.F299F|GPR56_uc002emd.2_Silent_p.F299F|GPR56_uc002eme.2_Silent_p.F299F|GPR56_uc010vht.1_Silent_p.F304F|GPR56_uc002emg.3_Silent_p.F299F|GPR56_uc010vhu.1_Silent_p.F124F	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	299	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						AAGCCCTGTTCCAGGTATGGG	0.582			NA											5	41					0	0	0.001168	0	0
KCTD19	146212	broad.mit.edu	37	16	67338468	67338468	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:67338468C>G	uc002esu.2	-	3	358	c.307G>C	c.(307-309)GAT>CAT	p.D103H	KCTD19_uc002est.2_5'UTR|KCTD19_uc010vjj.1_5'UTR	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	103						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TTCAGGTTATCTAGAGTCTGT	0.418			NA											15	74					0	0	0.003163	0	0
ZFHX3	463	broad.mit.edu	37	16	72828079	72828079	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:72828079G>C	uc002fck.2	-	9	9175	c.8502C>G	c.(8500-8502)GAC>GAG	p.D2834E	ZFHX3_uc002fcl.2_Missense_Mutation_p.D1920E	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2834					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CAGAGGAACAGTCATCGTTGT	0.468			NA											31	122					0	0	0.002096	0	0
PCGF2	7703	broad.mit.edu	37	17	36894636	36894636	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr17:36894636G>A	uc002hqp.1	-	9	789	c.546C>T	c.(544-546)CGC>CGT	p.R182R	PCGF2_uc002hqn.1_Nonsense_Mutation_p.Q184*|PCGF2_uc002hqo.1_Nonsense_Mutation_p.Q184*|PCGF2_uc010cvo.1_Silent_p.R57R|PCGF2_uc002hqq.1_Nonsense_Mutation_p.Q184*	NM_007144	NP_009075	P35227	PCGF2_HUMAN	ring finger protein 110	182					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2	Breast(7;9.07e-22)					CCATCTTGTTGCGGAGAAACT	0.572			NA											10	42					0	0	0.008291	0	0
CNP	1267	broad.mit.edu	37	17	40125654	40125654	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr17:40125654G>A	uc002hyl.1	+	4	1122	c.978G>A	c.(976-978)GGG>GGA	p.G326G	CNP_uc010wfz.1_Silent_p.G203G|CNP_uc002hym.1_Silent_p.G306G|CNP_uc010wga.1_Silent_p.G91G|CNP_uc002hyn.1_Silent_p.G91G	NM_033133	NP_149124	P09543	CN37_HUMAN	2',3'-cyclic nucleotide 3' phosphodiesterase	326					cell killing|cyclic nucleotide catabolic process|RNA metabolic process|synaptic transmission	extracellular space|melanosome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|ATP binding|protein binding				0		all_cancers(22;2.38e-06)|all_epithelial(22;6.79e-05)|Breast(137;0.000143)		UCEC - Uterine corpus endometrioid carcinoma (308;0.171)		TGCCGCGGGGGAGCCGCGCCC	0.647			NA											9	79					0	0	0.004482	0	0
HOXB6	3216	broad.mit.edu	37	17	46674022	46674022	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr17:46674022C>A	uc002ins.1	-	4	753	c.428G>T	c.(427-429)GGG>GTG	p.G143V	HOXB5_uc002inr.2_5'Flank|HOXB6_uc010dbh.1_Missense_Mutation_p.G143V|HOXB6_uc002int.1_3'UTR	NM_018952	NP_061825	P17509	HXB6_HUMAN	homeobox B6	143					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCGCTGGGCCCAAAGGAGGA	0.652			NA											8	80					0.000157383	0.000226303	0.00308	1	0
NOL11	25926	broad.mit.edu	37	17	65734086	65734086	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr17:65734086G>C	uc002jgd.1	+	13	1530	c.1527G>C	c.(1525-1527)TTG>TTC	p.L509F	NOL11_uc010wql.1_Missense_Mutation_p.L327F|NOL11_uc010deu.1_Missense_Mutation_p.L104F|SNORA38B_uc010dev.2_5'Flank	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	509						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			AAATTTTCTTGAGGTAAGTTA	0.328			NA											5	99					0	0	0.000602	0	0
JMJD6	23210	broad.mit.edu	37	17	74721760	74721760	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr17:74721760C>T	uc002jso.2	-	2	631	c.307G>A	c.(307-309)GAG>AAG	p.E103K	JMJD6_uc002jsn.1_Missense_Mutation_p.E103K|JMJD6_uc010dgz.2_Missense_Mutation_p.E103K|C17orf95_uc002jsp.2_5'Flank|C17orf95_uc002jsq.2_5'Flank|C17orf95_uc002jsr.2_5'Flank|C17orf95_uc002jss.2_5'Flank|C17orf95_uc002jst.2_5'Flank|C17orf95_uc002jsu.2_5'Flank	NM_015167	NP_055982	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6 isoform 2	103					mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			skin(2)|ovary(1)	3						TCGTTATCCTCACCACACTTG	0.468			NA											15	139					0	0	0.003163	0	0
CCDC57	284001	broad.mit.edu	37	17	80085740	80085740	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr17:80085740C>G	uc002kdx.1	-	16	2428	c.2391G>C	c.(2389-2391)CAG>CAC	p.Q797H	CCDC57_uc002kdy.2_Missense_Mutation_p.Q104H	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	798										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TGTCTTCTTTCTGCCGAGGTG	0.572			NA											8	84					0	0	0.000978	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892402	2892402	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr18:2892402G>C	uc002kln.2	+	4	2436	c.2277G>C	c.(2275-2277)AAG>AAC	p.K759N		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	759					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CTGGCCTGAAGAATTCAGTCC	0.468			NA											10	47					0	0	0.008291	0	0
ASXL3	80816	broad.mit.edu	37	18	31319901	31319901	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr18:31319901G>A	uc010dmg.1	+	11	2588	c.2533G>A	c.(2533-2535)GAG>AAG	p.E845K	ASXL3_uc002kxq.2_Missense_Mutation_p.E552K	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	845					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TGTTGACACTGAGAAGCCCTA	0.393			NA											6	36					0	0	0.001984	0	0
SLC39A6	25800	broad.mit.edu	37	18	33692482	33692482	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr18:33692482C>T	uc010dmy.2	-	8	2196	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	SLC39A6_uc002kzj.2_Missense_Mutation_p.E361K	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	636	Cytoplasmic (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						TGAGGCAACTCATGACAGAAC	0.378			NA											6	147					0	0	0.00308	0	0
PIK3C3	5289	broad.mit.edu	37	18	39620662	39620662	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr18:39620662C>T	uc002lap.2	+	19	2118	c.2060C>T	c.(2059-2061)TCA>TTA	p.S687L	PIK3C3_uc010xcl.1_Missense_Mutation_p.S624L|PIK3C3_uc002laq.2_Missense_Mutation_p.S172L|PIK3C3_uc002lar.1_Missense_Mutation_p.S71L	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	687	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						TTTATCCAGTCAGTTCCTGTG	0.343	NSCLC(37;552 1060 2683 16430 37914)		NA								TSP Lung(28;0.18)			9	66					0	0	0.008291	0	0
CDH7	1005	broad.mit.edu	37	18	63525118	63525118	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr18:63525118C>T	uc002ljz.2	+	8	1627	c.1302C>T	c.(1300-1302)ATC>ATT	p.I434I	CDH7_uc002lka.2_Silent_p.I434I|CDH7_uc002lkb.2_Silent_p.I434I	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	434	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GTGGGGTCATCACAACTGCCA	0.388			NA											9	41					0	0	0.008291	0	0
ZNF556	80032	broad.mit.edu	37	19	2876147	2876147	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:2876147G>A	uc002lwp.1	+	3	274	c.187G>A	c.(187-189)GAA>AAA	p.E63K	ZNF556_uc002lwq.2_Missense_Mutation_p.E63K	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACTTCTGGAGAAAAATTATC	0.373			NA											12	169					0	0	0.001368	0	0
STAP2	55620	broad.mit.edu	37	19	4338667	4338667	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:4338667C>T	uc002mab.2	-	1	181	c.84G>A	c.(82-84)AAG>AAA	p.K28K	STAP2_uc002mac.2_Silent_p.K28K|STAP2_uc002mad.2_5'UTR	NM_001013841	NP_001013863	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	28	PH.					cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGCCCCTTCTTCTCTAGAA	0.652			NA											7	41					0	0	0.001984	0	0
PLIN3	10226	broad.mit.edu	37	19	4847846	4847846	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:4847846G>A	uc002mbj.2	-	6	868	c.691C>T	c.(691-693)CAG>TAG	p.Q231*	PLIN3_uc002mbk.2_Nonsense_Mutation_p.Q219*|PLIN3_uc002mbl.3_Nonsense_Mutation_p.Q231*	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	231					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	CTCTGTTCCTGCCGCTGCTGC	0.612			NA											6	25					0	0	0.004482	0	0
C19orf45	374877	broad.mit.edu	37	19	7570435	7570435	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:7570435G>C	uc002mgm.2	+	6	1069	c.928G>C	c.(928-930)GAG>CAG	p.E310Q	C19orf45_uc010xjo.1_5'UTR	NM_198534	NP_940936	Q8NA69	CS045_HUMAN	hypothetical protein LOC374877	310											0						TCAGACTCCGGAGTCGCACAT	0.557			NA											12	68					0	0	0.000978	0	0
OR7G1	125962	broad.mit.edu	37	19	9226191	9226191	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:9226191C>T	uc002mks.1	-	1	249	c.249G>A	c.(247-249)GTG>GTA	p.V83V		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						CTTGGATGTTCACTAGGATCT	0.463			NA											18	160					0	0	0.007413	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221479	10221479	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:10221479G>A	uc002mna.2	+	11	1138	c.1138G>A	c.(1138-1140)GAT>AAT	p.D380N	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.D380N|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.D380N|PPAN_uc002mnb.1_Missense_Mutation_p.D327N	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	380					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TGAGGACGATGATGAACAGGA	0.612			NA											34	160					0	0	0.004289	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221527	10221527	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:10221527G>A	uc002mna.2	+	11	1186	c.1186G>A	c.(1186-1188)GAG>AAG	p.E396K	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.E396K|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Missense_Mutation_p.E396K|PPAN_uc002mnb.1_Missense_Mutation_p.E343K	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	396					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GGCGGTGGGCGAGGCGCCCAG	0.612			NA											35	150					0	0	0.004289	0	0
C19orf57	79173	broad.mit.edu	37	19	14006310	14006310	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:14006310G>A	uc002mxl.1	-	3	140	c.81C>T	c.(79-81)GAC>GAT	p.D27D	C19orf57_uc002mxk.1_5'Flank|C19orf57_uc002mxm.1_Silent_p.D27D	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	27					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CCCCATAGAAGTCTCCTAGCC	0.552			NA											22	177					0	0	0.002299	0	0
OR7A17	26333	broad.mit.edu	37	19	14992104	14992104	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:14992104C>G	uc010xob.1	-	1	64	c.64G>C	c.(64-66)GAA>CAA	p.E22Q		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GGCTGCAATTCTGGTTCCTCA	0.408			NA											5	29					0	0	0.001168	0	0
APLP1	333	broad.mit.edu	37	19	36362525	36362525	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:36362525C>T	uc002oce.2	+	5	687	c.549C>T	c.(547-549)TCC>TCT	p.S183S	APLP1_uc010xsz.1_Silent_p.S144S|APLP1_uc002ocf.2_Silent_p.S183S|APLP1_uc002ocg.2_Silent_p.S86S|APLP1_uc010xta.1_Silent_p.S177S	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	183	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTGCAGCTCCCAGGGCCTCA	0.647			NA											13	63					0	0	0.00245	0	0
AKT2	208	broad.mit.edu	37	19	40745969	40745969	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:40745969T>C	uc002onf.2	-	7	884	c.622A>G	c.(622-624)AGG>GGG	p.R208G	AKT2_uc010egs.2_Missense_Mutation_p.R208G|AKT2_uc010egt.2_Missense_Mutation_p.R146G|AKT2_uc010xvj.1_Missense_Mutation_p.R146G|AKT2_uc010egu.1_Missense_Mutation_p.R146G|AKT2_uc010xvk.1_Missense_Mutation_p.R208G|AKT2_uc002one.2_Missense_Mutation_p.R104G	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	208	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			AACGGGTGCCTGGTGTTCTGG	0.602			NA	A		ovarian|pancreatic 								4	236					0	0	0.001168	0	0
IL4I1	259307	broad.mit.edu	37	19	50397678	50397678	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:50397678G>A	uc002pqt.1	-	5	492	c.414C>T	c.(412-414)TTC>TTT	p.F138F	IL4I1_uc002pqv.1_Silent_p.F147F|IL4I1_uc010eno.1_Silent_p.F146F|IL4I1_uc002pqw.1_Silent_p.F146F|IL4I1_uc002pqu.1_Silent_p.F160F	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	138						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CGTACTGGGTGAACTTGGTCA	0.627			NA											12	85					0	0	0.001368	0	0
ZNF845	91664	broad.mit.edu	37	19	53855272	53855272	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr19:53855272C>T	uc010ydv.1	+	4	1461	c.1344C>T	c.(1342-1344)TTC>TTT	p.F448F	ZNF845_uc010ydw.1_Silent_p.F448F	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	448	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGAAGCTTTCAGTTTCAAAT	0.403			NA											7	58					0	0	0.001984	0	0
C2orf43	60526	broad.mit.edu	37	2	20939904	20939904	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:20939904C>T	uc002rec.2	-	5	563	c.530G>A	c.(529-531)AGA>AAA	p.R177K	C2orf43_uc002rea.1_Missense_Mutation_p.R177K|C2orf43_uc002reb.1_RNA|C2orf43_uc010yka.1_Intron|C2orf43_uc010ykb.1_Missense_Mutation_p.R47K|C2orf43_uc010ykc.1_Missense_Mutation_p.R129K|C2orf43_uc010ykd.1_Intron|C2orf43_uc010yke.1_Missense_Mutation_p.R135K|C2orf43_uc010ykf.1_Missense_Mutation_p.R47K	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	177											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTGGCAATTCTGCCATTGGG	0.403			NA											9	54					0	0	0.006214	0	0
ABHD1	84696	broad.mit.edu	37	2	27351351	27351351	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:27351351G>A	uc002rit.2	+	2	317	c.157G>A	c.(157-159)GAG>AAG	p.E53K	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_Intron	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	53						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCTTCCTGGAGCCACACTG	0.572			NA											12	106					0	0	0.00245	0	0
NLRC4	58484	broad.mit.edu	37	2	32475393	32475393	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:32475393G>C	uc002roi.2	-	4	1786	c.1540C>G	c.(1540-1542)CAA>GAA	p.Q514E	NLRC4_uc002roj.1_Missense_Mutation_p.Q514E|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	514					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAGCCGTGTTGATACACTGCT	0.507			NA											8	38					0	0	0.004482	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049530	69049530	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:69049530A>G	uc002seu.2	+	10	1620	c.1256A>G	c.(1255-1257)GAG>GGG	p.E419G	ARHGAP25_uc010fdg.2_Missense_Mutation_p.E420G|ARHGAP25_uc010yql.1_Missense_Mutation_p.E380G|ARHGAP25_uc002sew.2_Missense_Mutation_p.E412G|ARHGAP25_uc002sex.2_Missense_Mutation_p.E413G|ARHGAP25_uc002sey.2_Missense_Mutation_p.E146G	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	419					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GCGTTTCCGGAGGACAGCAGC	0.502			NA											4	167					0	0	0.000248	0	0
CCDC138	165055	broad.mit.edu	37	2	109415023	109415023	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:109415023G>A	uc002ten.1	+	6	776	c.716G>A	c.(715-717)AGA>AAA	p.R239K	CCDC138_uc002teo.1_Missense_Mutation_p.R239K|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	239	Potential.										0						GTTCTTACAAGATTTCAAATT	0.303			NA											6	58					0	0	0.001984	0	0
DPP10	57628	broad.mit.edu	37	2	116538488	116538488	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:116538488C>T	uc002tla.1	+	16	1857	c.1400C>T	c.(1399-1401)TCA>TTA	p.S467L	DPP10_uc002tlb.1_Missense_Mutation_p.S417L|DPP10_uc002tlc.1_Missense_Mutation_p.S463L|DPP10_uc002tle.2_Missense_Mutation_p.S471L|DPP10_uc002tlf.1_Missense_Mutation_p.S460L	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	467	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CAATGCATTTCATGTAATTTC	0.323			NA											10	93					0	0	0.008291	0	0
PLA2R1	22925	broad.mit.edu	37	2	160798460	160798460	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:160798460C>T	uc002ube.1	-	30	4428	c.4221G>A	c.(4219-4221)CTG>CTA	p.L1407L	PLA2R1_uc010zcp.1_Silent_p.L1405L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1407	Helical; (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CAATGACTATCAGTGTCAGTA	0.408			NA											13	80					0	0	0.00245	0	0
SCN3A	6328	broad.mit.edu	37	2	166011088	166011088	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:166011088C>T	uc002ucx.2	-	11	1746	c.1254G>A	c.(1252-1254)TTG>TTA	p.L418L	SCN3A_uc002ucy.2_Silent_p.L418L|SCN3A_uc002ucz.2_Silent_p.L418L|SCN3A_uc002uda.1_Silent_p.L287L|SCN3A_uc002udb.1_Silent_p.L287L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	418	Helical; Name=S6 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CAGCCAGGATCAAATTCACCA	0.458			NA											9	70					0	0	0.006214	0	0
LRP2	4036	broad.mit.edu	37	2	170145598	170145598	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:170145598C>G	uc002ues.2	-	9	1193	c.980G>C	c.(979-981)GGA>GCA	p.G327A	LRP2_uc010zdf.1_Missense_Mutation_p.G327A	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	327	EGF-like 1.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACGCTCCTCCATACGGCGT	0.483			NA											13	105					0	0	0.001855	0	0
GORASP2	26003	broad.mit.edu	37	2	171818224	171818224	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:171818224C>G	uc002ugk.2	+	8	1015	c.875C>G	c.(874-876)TCT>TGT	p.S292C	GORASP2_uc002ugj.2_Missense_Mutation_p.S224C|GORASP2_uc010zdl.1_Missense_Mutation_p.S304C|GORASP2_uc010zdm.1_Missense_Mutation_p.S248C|GORASP2_uc002ugl.2_Missense_Mutation_p.S224C|GORASP2_uc002ugm.2_Missense_Mutation_p.S74C	NM_015530	NP_056345	Q9H8Y8	GORS2_HUMAN	golgi reassembly stacking protein 2	292	Pro-rich.					Golgi membrane				breast(1)|central_nervous_system(1)	2						TCCCTCACTTCTGTGCCACCA	0.393			NA											14	141					0	0	0.00245	0	0
NFE2L2	4780	broad.mit.edu	37	2	178095793	178095793	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:178095793T>A	uc002ulh.3	-	5	2093	c.1538A>T	c.(1537-1539)AAT>ATT	p.N513I	NFE2L2_uc002ulg.3_Missense_Mutation_p.N497I|NFE2L2_uc010zfa.1_Missense_Mutation_p.N490I|NFE2L2_uc002uli.3_Missense_Mutation_p.N497I	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	513	Basic motif.				transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTTTCTGCAATTCTGAGCAGC	0.343			NA	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			6	74					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179429007	179429007	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:179429007G>A	uc010zfg.1	-	275	74372	c.74148C>T	c.(74146-74148)GTC>GTT	p.V24716V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.V18411V|TTN_uc010zfi.1_Silent_p.V18344V|TTN_uc010zfj.1_Silent_p.V18219V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25643							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACAACGATGACATCTTTAT	0.408			NA											18	152					0	0	0.00499	0	0
TTN	7273	broad.mit.edu	37	2	179462356	179462356	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:179462356C>G	uc010zfg.1	-	243	49973	c.49749G>C	c.(49747-49749)AAG>AAC	p.K16583N	uc002umo.2_RNA|uc002ump.1_RNA|TTN_uc010zfh.1_Missense_Mutation_p.K10278N|TTN_uc010zfi.1_Missense_Mutation_p.K10211N|TTN_uc010zfj.1_Missense_Mutation_p.K10086N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17510							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGGCAGTTCTTGATGACCA	0.438			NA											7	73					0	0	0.00308	0	0
TTN	7273	broad.mit.edu	37	2	179477958	179477958	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:179477958C>G	uc010zfg.1	-	213	42098	c.41874G>C	c.(41872-41874)TTG>TTC	p.L13958F	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.L7653F|TTN_uc010zfi.1_Missense_Mutation_p.L7586F|TTN_uc010zfj.1_Missense_Mutation_p.L7461F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14885							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTTTCAGCCAACACACGGA	0.348			NA											4	26					0	0	0.001984	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802056	185802056	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:185802056G>T	uc002uph.2	+	4	2527	c.1933G>T	c.(1933-1935)GCT>TCT	p.A645S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	645						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GCAGTATTTAGCTGCAGAGCA	0.353			NA											14	127					2.32078e-09	3.49707e-09	0.003163	1	0
DNAH7	56171	broad.mit.edu	37	2	196737073	196737073	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:196737073G>A	uc002utj.3	-	40	6635	c.6534C>T	c.(6532-6534)TTC>TTT	p.F2178F		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2178	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CACGGAGGTTGAACAAGTAGT	0.403			NA											7	79					0	0	0.00308	0	0
HECW2	57520	broad.mit.edu	37	2	197189815	197189815	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:197189815C>G	uc002utm.1	-	6	813	c.630G>C	c.(628-630)AAG>AAC	p.K210N	HECW2_uc002utl.1_Intron	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	210	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GAATTGACATCTTAAGATAAG	0.383			NA											22	153					0	0	0.001882	0	0
ZDBF2	57683	broad.mit.edu	37	2	207172245	207172245	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:207172245C>G	uc002vbp.2	+	5	3243	c.2993C>G	c.(2992-2994)TCA>TGA	p.S998*		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	998							nucleic acid binding|zinc ion binding			ovary(3)	3						TTCAGTGGTTCAAAAACAAGT	0.373			NA											9	77					0	0	0.004482	0	0
CPS1	1373	broad.mit.edu	37	2	211507249	211507249	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:211507249C>T	uc002vee.3	+	25	3133	c.3001C>T	c.(3001-3003)CGC>TGC	p.R1001C	CPS1_uc010fur.2_Missense_Mutation_p.R1007C|CPS1_uc010fus.2_Missense_Mutation_p.R550C	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1001					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTCTAGTATCCGCACACTGCG	0.453			NA											9	66					0	0	0.004482	0	0
AAMP	14	broad.mit.edu	37	2	219129318	219129318	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:219129318C>A	uc002vhk.2	-	11	1327	c.1243G>T	c.(1243-1245)GTG>TTG	p.V415L	AAMP_uc002vhj.2_Missense_Mutation_p.V396L|AAMP_uc010fvo.2_3'UTR|AAMP_uc002vhl.2_Missense_Mutation_p.V416L	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	415	WD 8.				angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGTCACCACCAGGGAGGCA	0.582			NA											14	65					9.31168e-06	1.36571e-05	0.001855	1	0
COL6A3	1293	broad.mit.edu	37	2	238262013	238262013	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:238262013C>G	uc002vwl.2	-	25	6946	c.6661G>C	c.(6661-6663)GAG>CAG	p.E2221Q	COL6A3_uc002vwo.2_Missense_Mutation_p.E2015Q|COL6A3_uc010znj.1_Missense_Mutation_p.E1614Q|COL6A3_uc002vwp.1_Missense_Mutation_p.E42Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2221	Triple-helical region.|Collagen-like 3.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGCTCTCCCTCAAAGCCCGGC	0.483			NA											6	49					0	0	0.001984	0	0
COL6A3	1293	broad.mit.edu	37	2	238283578	238283578	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:238283578C>G	uc002vwl.2	-	8	3441	c.3156G>C	c.(3154-3156)CAG>CAC	p.Q1052H	COL6A3_uc002vwo.2_Missense_Mutation_p.Q846H|COL6A3_uc010znj.1_Missense_Mutation_p.Q445H|COL6A3_uc002vwq.2_Missense_Mutation_p.Q846H|COL6A3_uc002vwr.2_Missense_Mutation_p.Q645H	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1052	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCACCACTCTCTGGACAAACT	0.582			NA											6	82					0	0	0.001168	0	0
KLHL30	377007	broad.mit.edu	37	2	239054455	239054455	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:239054455G>C	uc002vxr.1	+	4	1111	c.1078G>C	c.(1078-1080)GAG>CAG	p.E360Q		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	378	Kelch 3.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCTCAATGGGGAGATCTACGT	0.662			NA											3	22					0	0	0.004672	0	0
SEPT2	4735	broad.mit.edu	37	2	242265435	242265435	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:242265435G>A	uc002wbc.2	+	4	458	c.37G>A	c.(37-39)GAA>AAA	p.E13K	SEPT2_uc002wbd.2_Missense_Mutation_p.E13K|SEPT2_uc002wbf.2_Missense_Mutation_p.E13K|SEPT2_uc002wbg.2_Missense_Mutation_p.E13K|SEPT2_uc002wbh.2_Missense_Mutation_p.E13K|SEPT2_uc010zop.1_Missense_Mutation_p.E48K	NM_001008491	NP_001008491	Q15019	SEPT2_HUMAN	septin 2	13					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(1)	1		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		TATAAATCCAGAAACACCTGG	0.348			NA											4	35					0	0	0.000602	0	0
THAP4	51078	broad.mit.edu	37	2	242572898	242572898	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr2:242572898C>T	uc002wbt.2	-	2	897	c.674G>A	c.(673-675)GGA>GAA	p.G225E		NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	225							DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		CGCCCCAGATCCTGGGGGCGT	0.557			NA											14	112					0	0	0.00245	0	0
PLCB1	23236	broad.mit.edu	37	20	8639341	8639341	+	Silent	SNP	C	C	T	rs147648227		TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:8639341C>T	uc002wnb.2	+	9	855	c.852C>T	c.(850-852)CTC>CTT	p.L284L	PLCB1_uc010zrb.1_Silent_p.L183L|PLCB1_uc002wna.2_Silent_p.L284L|PLCB1_uc002wnc.1_Silent_p.L183L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	284					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity	p.L284L(1)		ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ACAACAGCCTCGCCAGAAAAG	0.443			NA											6	61					0	0	0.00308	0	0
DSTN	11034	broad.mit.edu	37	20	17581458	17581458	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:17581458G>C	uc002wpr.2	+	2	334	c.79G>C	c.(79-81)GAA>CAA	p.E27Q	DSTN_uc002wpq.2_Missense_Mutation_p.E10Q|DSTN_uc010gck.2_Missense_Mutation_p.E10Q	NM_006870	NP_006861	P60981	DEST_HUMAN	destrin isoform a	27	ADF-H.				actin filament severing|actin polymerization or depolymerization		actin binding			large_intestine(1)|skin(1)	2						CTCCACACCAGAAGAAATCAA	0.383			NA											8	50					0	0	0.00308	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20501653	20501653	+	Missense_Mutation	SNP	T	T	G	rs75943391		TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:20501653T>G	uc002wrz.2	-	31	4135	c.3992A>C	c.(3991-3993)GAC>GCC	p.D1331A	RALGAPA2_uc010gcx.2_Missense_Mutation_p.D1035A|RALGAPA2_uc010zsg.1_Missense_Mutation_p.D779A|RALGAPA2_uc002wsa.1_Missense_Mutation_p.D103A	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1331					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CAGGAAGGGGTCATAATCCGT	0.493			NA											10	70					0	0	0.002445	0	0
NINL	22981	broad.mit.edu	37	20	25459684	25459684	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:25459684G>A	uc002wux.1	-	16	2150	c.2076C>T	c.(2074-2076)GGC>GGT	p.G692G	NINL_uc010gdn.1_Silent_p.G692G|NINL_uc010gdo.1_Silent_p.G475G	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	692	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GCTCCTGCAGGCCCCAGATGA	0.692			NA											7	64					0	0	0.004482	0	0
C20orf132	140699	broad.mit.edu	37	20	35752146	35752146	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:35752146G>A	uc010zvu.1	-	17	1963	c.1872C>T	c.(1870-1872)TTC>TTT	p.F624F	C20orf132_uc002xgk.2_Silent_p.F246F	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:Variant_position_missing_in_Q9H579_after_alignment											0		Myeloproliferative disorder(115;0.00878)				GAAAGAGTCGGAACGTAGCTG	0.498			NA											8	56					0	0	0.00308	0	0
MATN4	8785	broad.mit.edu	37	20	43926892	43926892	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:43926892G>A	uc002xnn.2	-	7	1531	c.1344C>T	c.(1342-1344)AAC>AAT	p.N448N	MATN4_uc002xno.2_Silent_p.N407N|MATN4_uc002xnp.2_Silent_p.N366N|MATN4_uc010zwr.1_Silent_p.N396N|MATN4_uc002xnr.1_Silent_p.N448N	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	489	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				CACGAGGCACGTTAAGGGCAC	0.657			NA											5	62					0	0	0.000602	0	0
CDH22	64405	broad.mit.edu	37	20	44869617	44869617	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:44869617C>T	uc002xrm.2	-	2	936	c.535G>A	c.(535-537)GAG>AAG	p.E179K	CDH22_uc010ghk.1_Missense_Mutation_p.E179K	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	179	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGTGAGAGCTCGGCCACGCTG	0.622			NA											4	37					0	0	0.000248	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19670055	19670055	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr21:19670055G>A	uc002ykw.2	-	19	2288	c.2257C>T	c.(2257-2259)CCC>TCC	p.P753S		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	753	Extracellular (Potential).|SRCR.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						ACCCACCTGGGTGTTAGTATT	0.418			NA											5	40					0	0	0.000602	0	0
CLDN17	26285	broad.mit.edu	37	21	31538736	31538736	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr21:31538736T>C	uc011acv.1	-	1	200	c.200A>G	c.(199-201)TAT>TGT	p.Y67C		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	67	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						CAAGGAGCTATAGAACTTGCA	0.542			NA											20	88					0	0	0.008871	0	0
CABIN1	23523	broad.mit.edu	37	22	24509680	24509680	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr22:24509680C>T	uc002zzi.1	+	27	4392	c.4265C>T	c.(4264-4266)ACG>ATG	p.T1422M	CABIN1_uc002zzj.1_Missense_Mutation_p.T1343M|CABIN1_uc002zzl.1_Missense_Mutation_p.T1422M	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1422					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCAGGAGCGACGGGTAAAGAT	0.517			NA											5	111					0	0	0.000602	0	0
MORC2	22880	broad.mit.edu	37	22	31328534	31328534	+	Silent	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr22:31328534G>C	uc003aje.1	-	24	3923	c.2559C>G	c.(2557-2559)CTC>CTG	p.L853L		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	915							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						ACATGTACCGGAGGATCTGGA	0.562			NA											13	61					0	0	0.001368	0	0
CBY1	25776	broad.mit.edu	37	22	39069240	39069240	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr22:39069240G>A	uc003awb.2	+	6	656	c.380G>A	c.(379-381)TGA>TAA	p.*127*	CBY1_uc003awc.2_Silent_p.*127*|uc003awd.2_Intron	NM_001002880	NP_001002880	Q9Y3M2	CBY1_HUMAN	PKD2 interactor, golgi and endoplasmic reticulum	127					cardiac muscle cell differentiation|fat cell differentiation|negative regulation of transcription, DNA-dependent|protein localization	nuclear speck|trans-Golgi network	beta-catenin binding|identical protein binding			ovary(1)	1	Melanoma(58;0.04)					AAGAGAAAATGAAGACCCCAG	0.458			NA											8	38					0	0	0.004482	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39421648	39421648	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr22:39421648C>A	uc011aoe.1	+	4	631	c.577C>A	c.(577-579)CTG>ATG	p.L193M	APOBEC3D_uc011aod.1_Missense_Mutation_p.L262M|APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Missense_Mutation_p.L193M|APOBEC3D_uc010gxu.2_Intron	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	193					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					TTATGCATCCCTGCACCGCAC	0.522			NA											6	212					0.00198382	0.00283403	0.001984	1	0
TNFRSF13C	115650	broad.mit.edu	37	22	42321382	42321382	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr22:42321382C>T	uc003bbl.2	-	3	588	c.544G>A	c.(544-546)GAG>AAG	p.E182K	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|TNFRSF13C_uc010gyp.1_Missense_Mutation_p.E183K	NM_052945	NP_443177	Q96RJ3	TR13C_HUMAN	BAFF receptor	182	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TATTGTTGCTCAGGGCCGGCC	0.637			NA											4	22					0	0	0.000248	0	0
OXTR	5021	broad.mit.edu	37	3	8809434	8809434	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:8809434G>A	uc003brc.2	-	3	1062	c.440C>T	c.(439-441)TCG>TTG	p.S147L		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	147	Cytoplasmic (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GCGGCGCAGCGAGCGCAGCGG	0.692			NA											4	24					0	0	0.000602	0	0
TTLL3	26140	broad.mit.edu	37	3	9870813	9870813	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:9870813G>A	uc003btg.2	+	10	1504	c.1288G>A	c.(1288-1290)GAT>AAT	p.D430N	ARPC4_uc003btc.1_Missense_Mutation_p.D74N|TTLL3_uc003btd.3_Missense_Mutation_p.D397N|TTLL3_uc003btf.3_Missense_Mutation_p.D162N|TTLL3_uc010hco.1_Missense_Mutation_p.D366N|TTLL3_uc003bth.3_Missense_Mutation_p.D218N|TTLL3_uc011atj.1_Missense_Mutation_p.D366N|TTLL3_uc003btj.3_Missense_Mutation_p.D218N|TTLL3_uc003bti.3_Missense_Mutation_p.D218N	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	430	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					TGGCATGAAGGATGCTGTGAT	0.587			NA											6	34					0	0	0.001168	0	0
SEC13	6396	broad.mit.edu	37	3	10346800	10346800	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:10346800C>G	uc003bvn.2	-	7	744	c.625G>C	c.(625-627)GAA>CAA	p.E209Q	SEC13_uc003bvl.2_Missense_Mutation_p.E141Q|SEC13_uc003bvm.2_Missense_Mutation_p.E195Q|SEC13_uc003bvp.2_Missense_Mutation_p.E212Q|SEC13_uc003bvo.2_Missense_Mutation_p.E255Q|SEC13_uc003bvq.1_Missense_Mutation_p.E195Q|SEC13_uc003bvr.1_Missense_Mutation_p.E195Q	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	209					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						CTGTGCGCTTCTAGCTTCTGC	0.642			NA											7	34					0	0	0.001984	0	0
LSM3	27258	broad.mit.edu	37	3	14223145	14223145	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:14223145A>T	uc003byn.2	+	2	136	c.107A>T	c.(106-108)GAC>GTC	p.D36V	XPC_uc011ave.1_5'Flank|XPC_uc011avf.1_5'Flank|XPC_uc011avg.1_5'Flank	NM_014463	NP_055278	P62310	LSM3_HUMAN	Lsm3 protein	36					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	catalytic step 2 spliceosome|cytosol	protein binding|RNA binding			ovary(1)	1						ATGAGAAATGACCGAGAGCTT	0.368			NA											17	101					0	0	0.004007	0	0
SUSD5	26032	broad.mit.edu	37	3	33194491	33194491	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:33194491C>T	uc003cfo.1	-	5	2051	c.1633G>A	c.(1633-1635)GAA>AAA	p.E545K		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	545	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						CCGGGGCCTTCCTGTCCAAAG	0.582			NA											4	16					0	0	0.000248	0	0
SLC22A14	9389	broad.mit.edu	37	3	38348012	38348012	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:38348012G>C	uc010hhc.1	+	2	537	c.495G>C	c.(493-495)AAG>AAC	p.K165N	SLC22A14_uc003cia.2_Missense_Mutation_p.K165N|SLC22A14_uc003cib.2_Missense_Mutation_p.K165N|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	165	Extracellular (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CTGACGCTAAGAAGCGATCGC	0.433			NA											16	90					0	0	0.00499	0	0
ZNF167	55888	broad.mit.edu	37	3	44611964	44611964	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:44611964C>G	uc010hin.2	+	6	1750	c.1362C>G	c.(1360-1362)CTC>CTG	p.L454L	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Silent_p.L303L|ZNF167_uc003cnj.2_Silent_p.L454L|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	454	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		GCTCCCATCTCATTCAACACC	0.473	Esophageal Squamous(121;907 1626 38429 48584 52774)		NA											9	40					0	0	0.008291	0	0
FYCO1	79443	broad.mit.edu	37	3	46008734	46008734	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:46008734T>C	uc003cpb.3	-	8	2298	c.2092A>G	c.(2092-2094)AAG>GAG	p.K698E	FYCO1_uc011bal.1_Missense_Mutation_p.K698E	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	698	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		ATGGCCTCCTTCTCTGCCATC	0.622			NA											18	150					0	0	0.001523	0	0
XCR1	2829	broad.mit.edu	37	3	46063107	46063107	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:46063107G>A	uc003cpe.2	-	3	557	c.333C>T	c.(331-333)ATC>ATT	p.I111I	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Silent_p.I111I	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	111	Helical; Name=3; (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TGTAGAGGCTGATGGAGAAGA	0.582			NA											5	12					0	0	0.000602	0	0
EPHA3	2042	broad.mit.edu	37	3	89499479	89499479	+	Silent	SNP	G	G	C	rs145084709	byFrequency	TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:89499479G>C	uc003dqy.2	+	15	2874	c.2649G>C	c.(2647-2649)CGG>CGC	p.R883R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	883	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AGCTTATCCGGAATCCCGGCA	0.468			NA								TSP Lung(6;0.00050)			11	68					0	0	0.001368	0	0
PARP9	83666	broad.mit.edu	37	3	122269548	122269548	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:122269548C>G	uc010hri.2	-	6	1459	c.1314G>C	c.(1312-1314)AAG>AAC	p.K438N	PARP9_uc003eff.3_Missense_Mutation_p.K403N|PARP9_uc011bjs.1_Missense_Mutation_p.K403N|PARP9_uc003efg.2_Intron|PARP9_uc003efi.2_Missense_Mutation_p.K403N|PARP9_uc003efh.2_Missense_Mutation_p.K438N|PARP9_uc003efj.2_Missense_Mutation_p.K403N	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	438	Macro 2.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		CTGTTTCCTTCTTTATTTCCA	0.348			NA											4	33					0	0	0.000248	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039405	184039405	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:184039405C>T	uc003fnp.2	+	10	1231	c.1033C>T	c.(1033-1035)CTC>TTC	p.L345F	EIF4G1_uc003fno.1_Missense_Mutation_p.L286F|EIF4G1_uc010hxw.1_Missense_Mutation_p.L181F|EIF4G1_uc003fnt.2_Missense_Mutation_p.L56F|EIF4G1_uc003fnq.2_Missense_Mutation_p.L258F|EIF4G1_uc003fnr.2_Missense_Mutation_p.L181F|EIF4G1_uc010hxx.2_Missense_Mutation_p.L352F|EIF4G1_uc003fns.2_Missense_Mutation_p.L305F|EIF4G1_uc010hxy.2_Missense_Mutation_p.L352F|EIF4G1_uc003fnv.3_Missense_Mutation_p.L345F|EIF4G1_uc003fnu.3_Missense_Mutation_p.L345F|EIF4G1_uc003fnw.2_Missense_Mutation_p.L352F|EIF4G1_uc003fnx.2_Missense_Mutation_p.L149F|EIF4G1_uc003fny.3_Missense_Mutation_p.L149F	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	345					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCCAGTCCTCTCCAGGCTCC	0.527			NA											14	106					0	0	0.00245	0	0
EIF4G1	1981	broad.mit.edu	37	3	184040362	184040362	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:184040362C>T	uc003fnp.2	+	12	1837	c.1639C>T	c.(1639-1641)CAG>TAG	p.Q547*	EIF4G1_uc003fno.1_Nonsense_Mutation_p.Q488*|EIF4G1_uc010hxw.1_Nonsense_Mutation_p.Q383*|EIF4G1_uc003fnt.2_Nonsense_Mutation_p.Q258*|EIF4G1_uc003fnq.2_Nonsense_Mutation_p.Q460*|EIF4G1_uc003fnr.2_Nonsense_Mutation_p.Q383*|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.Q554*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.Q507*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.Q554*|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.Q547*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.Q547*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.Q554*|EIF4G1_uc003fnx.2_Nonsense_Mutation_p.Q351*|EIF4G1_uc003fny.3_Nonsense_Mutation_p.Q351*	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	547					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGTGGAAAATCAGCCTCCTGC	0.557			NA											4	31					0	0	0.000248	0	0
CLCN2	1181	broad.mit.edu	37	3	184072029	184072029	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:184072029C>G	uc003foi.2	-	15	1705	c.1581G>C	c.(1579-1581)CAG>CAC	p.Q527H	CLCN2_uc003foh.2_Missense_Mutation_p.Q51H|CLCN2_uc010hya.1_Missense_Mutation_p.Q510H|CLCN2_uc011brl.1_Missense_Mutation_p.Q527H|CLCN2_uc011brm.1_Missense_Mutation_p.Q483H	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	527						chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	TGTGGGCAATCTGGCCTGTGA	0.602			NA									OREG0015949	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	35					0	0	0.00308	0	0
C3orf59	151963	broad.mit.edu	37	3	192516720	192516720	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr3:192516720G>A	uc011bsp.1	-	2	1252	c.931C>T	c.(931-933)CAG>TAG	p.Q311*		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557			NA											5	32					0	0	0.001168	0	0
WHSC1	7468	broad.mit.edu	37	4	1962800	1962800	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:1962800C>T	uc003gdz.3	+	18	3470	c.3294C>T	c.(3292-3294)GAC>GAT	p.D1098D	WHSC1_uc003geb.3_Silent_p.D1098D|WHSC1_uc003gec.3_Silent_p.D1098D|WHSC1_uc003ged.3_Silent_p.D1098D|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Silent_p.D317D|WHSC1_uc011bvh.1_Silent_p.D159D|WHSC1_uc010icf.2_Silent_p.D446D	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1098	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AGCTGATCGACGAGGAGGAGT	0.512			NA	T	IGH@	MM								19	111					0	0	0.008871	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446410	10446410	+	Missense_Mutation	SNP	C	C	G	rs142752312	byFrequency	TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:10446410C>G	uc003gmn.2	-	3	2030	c.1543G>C	c.(1543-1545)GAA>CAA	p.E515Q		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						CTTCCACTTTCAGCAAAACAA	0.408			NA											14	78					0	0	0.00245	0	0
TBC1D1	23216	broad.mit.edu	37	4	38016340	38016340	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:38016340G>A	uc003gtb.2	+	3	971	c.628G>A	c.(628-630)GAG>AAG	p.E210K	TBC1D1_uc011byd.1_Missense_Mutation_p.E210K|TBC1D1_uc010ifd.2_Intron|TBC1D1_uc011byf.1_Missense_Mutation_p.E81K	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	210						nucleus	Rab GTPase activator activity			ovary(1)	1						CCGGGGGTCCGAGAGCCCCCG	0.711			NA											8	47					0	0	0.00308	0	0
TLR10	81793	broad.mit.edu	37	4	38776315	38776315	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:38776315C>T	uc003gti.2	-	2	1276	c.897G>A	c.(895-897)ATG>ATA	p.M299I	TLR10_uc003gtj.2_Missense_Mutation_p.M299I|TLR10_uc003gtk.2_Missense_Mutation_p.M299I	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	299	LRR 7.|Extracellular (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						TTATAGTTCTCATTACAGTAT	0.343			NA											5	54					0	0	0.000602	0	0
PHOX2B	8929	broad.mit.edu	37	4	41747895	41747895	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:41747895C>T	uc003gwf.3	-	3	1234	c.874G>A	c.(874-876)GCC>ACC	p.A292T		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	292				A -> G (in Ref. 1; BAA11555, 2; AAD26698 and 3; BAA82670).	positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						AGGACGCTGGCGAAGGGACCC	0.562			NA	Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				8	69					0	0	0.008291	0	0
ATP10D	57205	broad.mit.edu	37	4	47538713	47538713	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:47538713C>G	uc003gxk.1	+	9	1318	c.1154C>G	c.(1153-1155)CCT>CGT	p.P385R	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Intron	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	385	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.P385S(1)		ovary(2)|pancreas(1)	3						GTCTTGATTCCTATTTCTCTC	0.313			NA											6	65					0	0	0.001168	0	0
ANKRD17	26057	broad.mit.edu	37	4	73957704	73957704	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:73957704G>A	uc003hgp.2	-	29	5758	c.5641C>T	c.(5641-5643)CTT>TTT	p.L1881F	ANKRD17_uc003hgo.2_Missense_Mutation_p.L1768F|ANKRD17_uc003hgq.2_Missense_Mutation_p.L1630F|ANKRD17_uc003hgr.2_Missense_Mutation_p.L1880F	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1881					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCTAATGGAAGAGAAACTGGA	0.483			NA											19	140					0	0	0.007413	0	0
CNOT6L	246175	broad.mit.edu	37	4	78663394	78663394	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:78663394C>A	uc011ccd.1	-	8	904	c.773G>T	c.(772-774)GGA>GTA	p.G258V	CNOT6L_uc003hks.2_Missense_Mutation_p.G258V|CNOT6L_uc003hkt.1_Missense_Mutation_p.G101V|CNOT6L_uc011cce.1_Missense_Mutation_p.W205C	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	258					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						TCCATCATATCCACGCTCCTT	0.393			NA											4	23					1.23904e-05	1.81122e-05	0.000602	1	0
ANXA3	306	broad.mit.edu	37	4	79503336	79503336	+	Silent	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:79503336G>T	uc003hld.2	+	5	514	c.204G>T	c.(202-204)CTG>CTT	p.L68L	ANXA3_uc003hle.2_Silent_p.L29L|ANXA3_uc010ijk.2_Silent_p.L29L	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	68	Annexin 1.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						TTTAGGAGCTGAAAGATGACT	0.393	GBM(2;126 157 27790 28920 42492)		NA											9	52					0.00621372	0.00881947	0.006214	1	0
PRKG2	5593	broad.mit.edu	37	4	82031655	82031655	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:82031655G>C	uc003hmh.2	-	14	1901	c.1887C>G	c.(1885-1887)TTC>TTG	p.F629L	PRKG2_uc011ccf.1_Missense_Mutation_p.F209L|PRKG2_uc011ccg.1_Missense_Mutation_p.F209L|PRKG2_uc011cch.1_Missense_Mutation_p.F600L	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	629	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						AATCCACACTGAAGTCATGTC	0.438			NA											14	54					0	0	0.001855	0	0
THAP9	79725	broad.mit.edu	37	4	83827511	83827511	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:83827511G>C	uc003hnt.2	+	3	430	c.311G>C	c.(310-312)AGA>ACA	p.R104T	THAP9_uc003hns.1_5'UTR|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_5'UTR	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	104							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				GGTAAAGCAAGACAAAAAATC	0.318			NA											7	115					0	0	0.001984	0	0
WDFY3	23001	broad.mit.edu	37	4	85722828	85722828	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:85722828G>C	uc003hpd.2	-	17	3205	c.2797C>G	c.(2797-2799)CAG>GAG	p.Q933E		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	933						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCAGAGCCTGAGAGGCTAAT	0.483			NA											10	94					0	0	0.001368	0	0
GRID2	2895	broad.mit.edu	37	4	94006245	94006245	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:94006245C>T	uc011cdt.1	+	3	602	c.344C>T	c.(343-345)CCC>CTC	p.P115L	GRID2_uc010ikx.2_Missense_Mutation_p.P115L|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	115	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATGCATATCCCCCACCTCTTC	0.562			NA											11	60					0	0	0.008291	0	0
MANBA	4126	broad.mit.edu	37	4	103644166	103644166	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:103644166C>T	uc003hwg.2	-	4	511	c.411G>A	c.(409-411)GTG>GTA	p.V137V	MANBA_uc011ces.1_Intron	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	137					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		CAATGGAGTTCACGTCCCTGA	0.473			NA											5	49					0	0	0.000602	0	0
LEF1	51176	broad.mit.edu	37	4	109084728	109084728	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:109084728C>T	uc003hyt.1	-	3	1065	c.410G>A	c.(409-411)AGA>AAA	p.R137K	LEF1_uc011cfj.1_Missense_Mutation_p.R22K|LEF1_uc011cfk.1_Missense_Mutation_p.R69K|LEF1_uc003hyu.1_Missense_Mutation_p.R137K|LEF1_uc003hyv.1_Missense_Mutation_p.R137K|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	137	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		ACTTACTGTTCTCGGGATGGG	0.383			NA											8	92					0	0	0.004482	0	0
ARSJ	79642	broad.mit.edu	37	4	114899776	114899776	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:114899776G>A	uc003ibq.1	-	1	1103	c.215C>T	c.(214-216)TCC>TTC	p.S72F	ARSJ_uc010imu.1_Missense_Mutation_p.S72F|ARSJ_uc010imv.1_5'UTR	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	72						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		CTGGGAGGTGGAAGTTGTGCT	0.502			NA											13	62					0	0	0.001855	0	0
PLK4	10733	broad.mit.edu	37	4	128802317	128802317	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:128802317G>C	uc003ifo.2	+	1	273	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	PLK4_uc011cgs.1_Missense_Mutation_p.E10Q|PLK4_uc011cgt.1_5'Flank	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	10					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GGAGAAGATCGAGGTGAAAAG	0.607	Colon(135;508 1718 19061 31832 42879)		NA											4	41					0	0	0.000248	0	0
MAB21L2	10586	broad.mit.edu	37	4	151504343	151504343	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:151504343C>T	uc003ilw.2	+	1	1267	c.162C>T	c.(160-162)AGC>AGT	p.S54S	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	54					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GCTTCATCAGCTCCTTGAGCG	0.587			NA											6	27					0	0	0.001168	0	0
LRBA	987	broad.mit.edu	37	4	151773315	151773315	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr4:151773315T>C	uc010ipj.2	-	23	4021	c.3547A>G	c.(3547-3549)ACA>GCA	p.T1183A	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Missense_Mutation_p.T1183A	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1183						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CCTGATGCTGTCATAGTCTGA	0.383			NA											14	88					0	0	0.00245	0	0
SLC12A7	10723	broad.mit.edu	37	5	1089171	1089171	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:1089171G>A	uc003jbu.2	-	4	481	c.415C>T	c.(415-417)CTG>TTG	p.L139L		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	139	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GTCAGGCGCAGGAAGAGGATG	0.647			NA											18	249					0	0	0.008871	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5182332	5182332	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:5182332G>T	uc003jdl.2	+	4	815	c.677G>T	c.(676-678)TGG>TTG	p.W226L	ADAMTS16_uc003jdk.1_Missense_Mutation_p.W226L|ADAMTS16_uc003jdj.1_Missense_Mutation_p.W226L	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	226					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCAAGGACATGGGAGCTGGCA	0.577			NA											7	147					2.0095e-06	2.96704e-06	0.001984	1	0
MTRR	4552	broad.mit.edu	37	5	7878244	7878244	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:7878244G>C	uc003jed.2	+	5	700	c.670G>C	c.(670-672)GAT>CAT	p.D224H	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.D197H|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	224	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TCTGAGATTCGATGATTCAGG	0.468			NA											13	106					0	0	0.00245	0	0
MTRR	4552	broad.mit.edu	37	5	7878333	7878333	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:7878333C>T	uc003jed.2	+	5	789	c.759C>T	c.(757-759)TCC>TCT	p.S253S	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Silent_p.S226S|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	253	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	ACTTTGAGTCCTCACTTACCC	0.443			NA											10	194					0	0	0.006214	0	0
SEMA5A	9037	broad.mit.edu	37	5	9043069	9043069	+	Silent	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:9043069G>C	uc003jek.2	-	23	3877	c.3165C>G	c.(3163-3165)CTC>CTG	p.L1055L		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	1055	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TCTTCCCAGTGAGATGTGGGT	0.338			NA											7	47					0	0	0.001984	0	0
FBXL7	23194	broad.mit.edu	37	5	15937263	15937263	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:15937263G>A	uc003jfn.1	+	4	1925	c.1444G>A	c.(1444-1446)GTC>ATC	p.V482I		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	482					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CAAGCGCTGCGTCATCGAGCA	0.542			NA											6	26					0	0	0.001168	0	0
GAPT	202309	broad.mit.edu	37	5	57790482	57790482	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:57790482G>A	uc003jro.1	+	3	513	c.119G>A	c.(118-120)CGA>CAA	p.R40Q		NM_152687	NP_689900	Q8N292	GAPT_HUMAN	GRB2-binding adaptor protein, transmembrane	40					B cell activation	integral to membrane|plasma membrane					0						GTTGCCACACGATTTACCTTA	0.433			NA											10	58					0	0	0.008291	0	0
OTP	23440	broad.mit.edu	37	5	76932692	76932692	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:76932692C>G	uc003kfg.2	-	2	549	c.401G>C	c.(400-402)CGT>CCT	p.R134P		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	134	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		CAGCTCCTCACGCATAAAGAT	0.612			NA											8	107					0	0	0.00308	0	0
OTP	23440	broad.mit.edu	37	5	76932712	76932712	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:76932712G>C	uc003kfg.2	-	2	529	c.381C>G	c.(379-381)CAC>CAG	p.H127Q		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	127	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		TGTCGGGGTAGTGAGTCTTGG	0.622			NA											15	123					0	0	0.003163	0	0
ACOT12	134526	broad.mit.edu	37	5	80626663	80626663	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:80626663G>A	uc003khl.3	-	14	1543	c.1488C>T	c.(1486-1488)CTC>CTT	p.L496L	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	496	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TAGCATGGATGAGAAATCCGG	0.433			NA											4	39					0	0	0.000248	0	0
TTC37	9652	broad.mit.edu	37	5	94857809	94857809	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:94857809G>C	uc003klb.2	-	19	2230	c.1960C>G	c.(1960-1962)CAA>GAA	p.Q654E	TTC37_uc010jbf.1_Missense_Mutation_p.Q606E	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	654	TPR 11.						binding			ovary(3)|pancreas(1)	4						ATCTGGTATTGAGCTACAGCC	0.358			NA											7	89					0	0	0.004482	0	0
MEGF10	84466	broad.mit.edu	37	5	126792896	126792896	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:126792896G>A	uc003kuh.3	+	26	3671	c.3309G>A	c.(3307-3309)AAG>AAA	p.K1103K	MEGF10_uc003kui.3_Silent_p.K1103K	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	1103	Cytoplasmic (Potential).|Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACCTCCCAAAGAACAGTCACA	0.433			NA											11	110					0	0	0.000978	0	0
KDM3B	51780	broad.mit.edu	37	5	137754766	137754766	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:137754766G>A	uc003lcy.1	+	14	3760	c.3560G>A	c.(3559-3561)AGA>AAA	p.R1187K	KDM3B_uc010jew.1_Missense_Mutation_p.R843K|KDM3B_uc011cys.1_Missense_Mutation_p.R219K	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1187					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						ACTGACATCAGATCTGAAGAG	0.537			NA											11	71					0	0	0.008291	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755330	140755330	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:140755330C>T	uc003ljy.1	+	1	1680	c.1680C>T	c.(1678-1680)CCC>CCT	p.P560P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.P560P	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	560	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAATGCGCCCGAGATCCTGT	0.657			NA											29	176					0	0	0.008361	0	0
HTR4	3360	broad.mit.edu	37	5	147830796	147830796	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:147830796C>G	uc003lpj.1	-	7	1280	c.1116G>C	c.(1114-1116)GAG>GAC	p.E372D	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_3'UTR	NM_001040169	NP_001035259	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform a	Error:Variant_position_missing_in_Q13639_after_alignment					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	TGGGCAGTTTCTCGAGTTCCT	0.473	GBM(120;370 1604 14007 17804 41573)		NA											36	322					0	0	0.007835	0	0
LCP2	3937	broad.mit.edu	37	5	169683535	169683535	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:169683535G>C	uc003man.1	-	17	1352	c.1145C>G	c.(1144-1146)TCT>TGT	p.S382C	LCP2_uc011des.1_Missense_Mutation_p.S177C|LCP2_uc011det.1_Missense_Mutation_p.S211C	NM_005565	NP_005556	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2	382					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		CAAACCTTGAGAGAAGTATGG	0.453			NA											4	63					0	0	0.000602	0	0
FGFR4	2264	broad.mit.edu	37	5	176520438	176520438	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:176520438C>T	uc003mfl.2	+	10	1450	c.1283C>T	c.(1282-1284)TCA>TTA	p.S428L	FGFR4_uc003mfm.2_Missense_Mutation_p.S428L|FGFR4_uc011dfu.1_Nonsense_Mutation_p.Q377*|FGFR4_uc003mfo.2_Missense_Mutation_p.S388L	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	428	Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	TCCGGCAAGTCAAGCTCATCC	0.622			NA								TSP Lung(9;0.080)			15	124					0	0	0.00245	0	0
OR2V2	285659	broad.mit.edu	37	5	180582116	180582116	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:180582116C>T	uc011dhj.1	+	1	174	c.174C>T	c.(172-174)ACC>ACT	p.T58T		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	58	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCTTCACACCCCCATGTACT	0.537			NA											41	167					0	0	0.00874	0	0
CDYL	9425	broad.mit.edu	37	6	4892238	4892238	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:4892238G>T	uc003mwi.2	+	4	609	c.478G>T	c.(478-480)GAA>TAA	p.E160*	CDYL_uc003mwj.2_Nonsense_Mutation_p.E106*|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_5'UTR|CDYL_uc011dhy.1_5'UTR	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	160					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		GAAAGACCACGAATCCAAAAA	0.502			NA											16	95					6.72482e-11	1.03098e-10	0.003163	1	0
ATXN1	6310	broad.mit.edu	37	6	16327156	16327156	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:16327156G>A	uc003nbt.2	-	8	2357	c.1386C>T	c.(1384-1386)ATC>ATT	p.I462I	ATXN1_uc010jpi.2_Silent_p.I462I|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	462					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TCAGGTAGCCGATGACAGGGG	0.657			NA											21	154					0	0	0.008871	0	0
PGBD1	84547	broad.mit.edu	37	6	28269471	28269471	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:28269471C>G	uc003nky.2	+	7	2210	c.1840C>G	c.(1840-1842)CTT>GTT	p.L614V	PGBD1_uc003nkz.2_Missense_Mutation_p.L614V	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	614					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CGCTGATGTTCTTTTAGAGAG	0.418			NA											15	109					0	0	0.00499	0	0
HLA-DQB1	3119	broad.mit.edu	37	6	32632765	32632765	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:32632765G>C	uc003obw.2	-	2	271	c.189C>G	c.(187-189)ATC>ATG	p.I63M	HLA-DQB1_uc010juc.1_Missense_Mutation_p.I18M|HLA-DQB1_uc003obv.2_Missense_Mutation_p.I63M|HLA-DQB1_uc011dqd.1_Missense_Mutation_p.I63M|HLA-DQB1_uc011dqe.1_Missense_Mutation_p.I63M	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	63	Extracellular (Potential).|Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCGGTTATAGATGTATCTGG	0.617	Esophageal Squamous(151;720 1825 15000 40336 43415)		NA							Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				19	61					0	0	0.007413	0	0
ITPR3	3710	broad.mit.edu	37	6	33654857	33654857	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:33654857C>G	uc011drk.1	+	44	6270	c.6051C>G	c.(6049-6051)CTC>CTG	p.L2017L	ITPR3_uc003oey.2_Silent_p.L104L	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2017	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						AGCGAATCCTCATCAGCCTGC	0.667			NA											15	68					0	0	0.003163	0	0
PTK7	5754	broad.mit.edu	37	6	43109431	43109431	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:43109431G>A	uc003oub.1	+	11	1842	c.1644G>A	c.(1642-1644)GTG>GTA	p.V548V	PTK7_uc003ouc.1_Silent_p.V548V|PTK7_uc003oud.1_Silent_p.V508V|PTK7_uc003oue.1_Silent_p.V418V|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.V556V|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	548	Ig-like C2-type 6.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CAGAGTGGGTGACAGACAACG	0.572			NA											9	135					0	0	0.006214	0	0
SMPDL3A	10924	broad.mit.edu	37	6	123118004	123118004	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:123118004C>T	uc003pzg.2	+	3	883	c.362C>T	c.(361-363)TCA>TTA	p.S121L	SMPDL3A_uc003pzh.2_5'UTR	NM_006714	NP_006705	Q92484	ASM3A_HUMAN	acid sphingomyelinase-like phosphodiesterase 3A	121					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity				0				GBM - Glioblastoma multiforme(226;0.236)		CCTGAACTCTCAACAGACACT	0.393			NA											5	50					0	0	0.001168	0	0
IL20RA	53832	broad.mit.edu	37	6	137322794	137322794	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:137322794G>A	uc003qhj.2	-	7	1996	c.1563C>T	c.(1561-1563)CTC>CTT	p.L521L	IL20RA_uc011edl.1_Silent_p.L472L|IL20RA_uc003qhk.2_Silent_p.L410L|IL20RA_uc003qhi.2_Silent_p.L253L	NM_014432	NP_055247	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha precursor	521	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(2)|skin(2)	4	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		GCTCCTCATAGAGTCTAGATA	0.527			NA											11	121					0	0	0.000978	0	0
ARID1B	57492	broad.mit.edu	37	6	157528089	157528090	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:157528089_157528090GG>TT	uc003qqn.2	+	20	5912_5913	c.5760_5761GG>TT	c.(5758-5763)CAGGAC>CATTAC	p.1920_1921QD>HY	ARID1B_uc003qqo.2_Missense_Mutation_p.1880_1881QD>HY|ARID1B_uc003qqp.2_Missense_Mutation_p.1867_1868QD>HY	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1925_1926					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CGCACTGGCAGGACTCGCTGGC	0.55			NA											16	137					0	0	0.004672	0	0
CCR6	1235	broad.mit.edu	37	6	167550322	167550322	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:167550322C>A	uc003qvl.2	+	13	3080	c.604C>A	c.(604-606)CAG>AAG	p.Q202K	CCR6_uc010kkm.2_Missense_Mutation_p.Q202K|CCR6_uc003qvn.3_Missense_Mutation_p.Q202K|CCR6_uc003qvm.3_Missense_Mutation_p.Q202K	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	202	Extracellular (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		ACCCAAGTACCAGACTGTCTC	0.468			NA											8	69					0.00448238	0.00638268	0.004482	1	0
GPR31	2853	broad.mit.edu	37	6	167570790	167570790	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:167570790C>G	uc011egq.1	-	1	530	c.530G>C	c.(529-531)TGG>TCG	p.W177S		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	177	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		TGCTTCCTGCCAGATGATGCT	0.592			NA											17	149					0	0	0.004007	0	0
CARD11	84433	broad.mit.edu	37	7	2953041	2953041	+	Missense_Mutation	SNP	G	G	A	rs149857605	byFrequency	TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:2953041G>A	uc003smv.2	-	22	3303	c.2899C>T	c.(2899-2901)CGC>TGC	p.R967C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	967					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TAGAAGGCGCGTACCAGGCTG	0.677			NA	Mis		DLBCL								6	67					0	0	0.001984	0	0
PMS2	5395	broad.mit.edu	37	7	6043687	6043687	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:6043687G>C	uc003spl.2	-	3	253	c.166C>G	c.(166-168)CTA>GTA	p.L56V	PMS2_uc003spj.2_Translation_Start_Site|PMS2_uc003spk.2_Translation_Start_Site|PMS2_uc011jwl.1_Translation_Start_Site|PMS2_uc010ktg.2_Translation_Start_Site|PMS2_uc010kte.2_Missense_Mutation_p.L56V|PMS2_uc010ktf.1_Missense_Mutation_p.L56V	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	56					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		TTAAGCTTTAGATCTAGAAAG	0.294			NA	Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				11	60					0	0	0.000978	0	0
AHR	196	broad.mit.edu	37	7	17367416	17367416	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:17367416G>A	uc011jxz.1	+	4	1007	c.394G>A	c.(394-396)GAT>AAT	p.D132N	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	132	PAS 1.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TGTCACTACAGATGCTTTGGT	0.269			NA											10	108					0	0	0.000978	0	0
CLK2P	1197	broad.mit.edu	37	7	23625387	23625387	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:23625387T>A	uc003swk.2	-	1	760	c.110A>T	c.(109-111)CAC>CTC	p.H37L		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						GTGCACTTGGTGGATGGGGTA	0.507			NA											14	61					0	0	0.001855	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31142970	31142970	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:31142970G>T	uc003tca.1	+	14	1389	c.1166G>T	c.(1165-1167)GGC>GTC	p.G389V	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.G368V|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.G417V|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.G417V|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.G416V|ADCYAP1R1_uc003tcf.1_Missense_Mutation_p.G147V	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	389	Helical; Name=7; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						CTGGGGCTGGGCTCCTTCCAG	0.547	Ovarian(44;225 1186 2158 11092)		NA											12	61					1.08611e-07	1.62547e-07	0.000978	1	0
ZNF107	51427	broad.mit.edu	37	7	64168600	64168600	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:64168600G>A	uc003ttd.2	+	7	2704	c.1918G>A	c.(1918-1920)GAA>AAA	p.E640K	ZNF107_uc003tte.2_Missense_Mutation_p.E640K	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	640	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CCAATGTGCAGAATGTGGCAA	0.373			NA											5	48					0	0	0.001168	0	0
FKBP6	8468	broad.mit.edu	37	7	72744349	72744349	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:72744349C>T	uc003tya.2	+	4	594	c.462C>T	c.(460-462)CTC>CTT	p.L154L	FKBP6_uc003twz.2_Intron|FKBP6_uc011kew.1_Silent_p.L149L|FKBP6_uc010lbe.1_RNA|TRIM50_uc003txy.1_5'Flank|TRIM50_uc003txz.1_5'Flank	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	154					protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				TTTGTGCTCTCTCAGCTGTAA	0.498			NA											10	75					0	0	0.006214	0	0
HIP1	3092	broad.mit.edu	37	7	75228554	75228554	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:75228554G>C	uc003uds.1	-	2	173	c.132C>G	c.(130-132)ATC>ATG	p.I44M		NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	44	ENTH.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TGGCCTTATTGATGCTGACAG	0.507			NA	T	PDGFRB	CMML								17	168					0	0	0.002299	0	0
HGF	3082	broad.mit.edu	37	7	81335005	81335005	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:81335005C>T	uc003uhl.2	-	16	1987	c.1822G>A	c.(1822-1824)GAA>AAA	p.E608K	HGF_uc003uhm.2_Missense_Mutation_p.E603K	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	608	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CTGGTCTTTTCAGGAATTGTG	0.358			NA											4	35					0	0	0.000602	0	0
ZNF498	221785	broad.mit.edu	37	7	99217442	99217442	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:99217442G>A	uc003url.1	+	4	540	c.213G>A	c.(211-213)CTG>CTA	p.L71L	ZNF498_uc003urm.1_5'UTR|ZNF498_uc010lge.1_5'UTR|ZNF498_uc003urn.2_RNA|ZNF498_uc010lgf.1_Silent_p.L71L|ZNF498_uc003uro.1_5'Flank	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	71	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GTCGGTGGCTGAGGCCCGAGT	0.622			NA											16	90					0	0	0.00499	0	0
PNPLA8	50640	broad.mit.edu	37	7	108155227	108155227	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:108155227C>T	uc003vff.1	-	4	1116	c.709G>A	c.(709-711)GAA>AAA	p.E237K	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.E237K|PNPLA8_uc003vfi.1_Missense_Mutation_p.E137K|PNPLA8_uc003vfj.1_Missense_Mutation_p.E237K|PNPLA8_uc003vfk.1_Missense_Mutation_p.E137K	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	237					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						TTTTTATCTTCAAGTTCTGAT	0.363			NA											5	34					0	0	0.001168	0	0
TMEM209	84928	broad.mit.edu	37	7	129843654	129843654	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:129843654A>C	uc003vpn.2	-	3	296	c.173T>G	c.(172-174)GTG>GGG	p.V58G	TMEM209_uc010lmc.1_Missense_Mutation_p.V58G|TMEM209_uc003vpo.2_Missense_Mutation_p.V58G	NM_032842	NP_116231	Q96SK2	TM209_HUMAN	transmembrane protein 209	58						integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)					CCAGTATGTCACATTGTAGTA	0.313			NA											3	11					0	0	0.000248	0	0
DENND2A	27147	broad.mit.edu	37	7	140221722	140221722	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:140221722G>A	uc010lnj.2	-	16	2989	c.2844C>T	c.(2842-2844)GTC>GTT	p.V948V	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.V948V|DENND2A_uc003vvw.2_Silent_p.V948V	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	948	dDENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TCTCCATGAAGACCTCCAGGA	0.617			NA											4	47					0	0	0.000248	0	0
CLCN1	1180	broad.mit.edu	37	7	143047716	143047716	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:143047716G>T	uc003wcr.1	+	22	2651	c.2564G>T	c.(2563-2565)GGG>GTG	p.G855V	CLCN1_uc011ktc.1_Missense_Mutation_p.G467V	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	855	CBS 2.|Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					ACCAGCATGGGGAAGCTCAGG	0.582			NA											19	173					2.37509e-13	3.66681e-13	0.001523	1	0
OR2A25	392138	broad.mit.edu	37	7	143771395	143771395	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:143771395G>A	uc011ktx.1	+	1	83	c.83G>A	c.(82-84)GGG>GAG	p.G28E		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					CTCCTCTTTGGGCTCTTCTCC	0.507			NA											11	91					0	0	0.008291	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144070344	144070344	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:144070344C>T	uc003wel.2	+	10	4225	c.4107C>T	c.(4105-4107)ATC>ATT	p.I1369I	ARHGEF5_uc003wek.2_Silent_p.I1369I|ARHGEF5_uc003wem.2_Silent_p.I224I	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1369					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					AGGAACTAATCTACCTGAGCC	0.532			NA											13	198					0	0	0.00245	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1905296	1905296	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:1905296C>A	uc003wpr.2	+	29	4080	c.3902C>A	c.(3901-3903)GCC>GAC	p.A1301D	ARHGEF10_uc003wps.2_Missense_Mutation_p.A1263D|ARHGEF10_uc010lre.2_Missense_Mutation_p.A952D	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1326					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		GCCAAGAAAGCCAAGGCCAGC	0.647			NA											5	49					0.00198382	0.00283403	0.001984	1	0
CSMD1	64478	broad.mit.edu	37	8	2965255	2965255	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:2965255C>T	uc011kwk.1	-	45	7213	c.6823G>A	c.(6823-6825)GAT>AAT	p.D2275N	CSMD1_uc011kwj.1_Missense_Mutation_p.D1667N|CSMD1_uc010lrg.2_Missense_Mutation_p.D343N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2275	Extracellular (Potential).|Sushi 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCGAAATCATCATCCTCAGTA	0.358			NA											8	89					0	0	0.001368	0	0
CSMD1	64478	broad.mit.edu	37	8	2965273	2965273	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:2965273C>G	uc011kwk.1	-	45	7195	c.6805G>C	c.(6805-6807)GAA>CAA	p.E2269Q	CSMD1_uc011kwj.1_Missense_Mutation_p.E1661Q|CSMD1_uc010lrg.2_Missense_Mutation_p.E337Q	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2269	Extracellular (Potential).|Sushi 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTAAGCATTTCTGCCTGTGGA	0.353			NA											11	100					0	0	0.007413	0	0
SOX7	83595	broad.mit.edu	37	8	10583724	10583724	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:10583724G>A	uc003wtf.2	-	2	770	c.691C>T	c.(691-693)CCC>TCC	p.P231S	SOX7_uc011kwz.1_Missense_Mutation_p.P283S	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	231					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		ATGCGGCGGGGATGGCCATGC	0.687			NA											9	41					0	0	0.000978	0	0
FGL1	2267	broad.mit.edu	37	8	17739550	17739550	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:17739550C>T	uc003wxx.2	-	4	526	c.202G>A	c.(202-204)GAG>AAG	p.E68K	FGL1_uc003wxy.2_Missense_Mutation_p.E68K|FGL1_uc003wxz.2_Missense_Mutation_p.E68K|FGL1_uc003wya.2_Missense_Mutation_p.E68K|FGL1_uc003wyb.2_Missense_Mutation_p.E68K|FGL1_uc003wyc.2_Missense_Mutation_p.E68K|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Missense_Mutation_p.E118K|FGL1_uc003wyf.2_Missense_Mutation_p.E38K	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	68					signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		ACAGTATTCTCATCTCCTTTA	0.448			NA											9	56					0	0	0.008291	0	0
TMEM67	91147	broad.mit.edu	37	8	94767363	94767363	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:94767363G>A	uc011lgk.1	+	1	292	c.221G>A	c.(220-222)CGA>CAA	p.R74Q	TMEM67_uc010mau.2_Missense_Mutation_p.R74Q|TMEM67_uc010mav.2_Missense_Mutation_p.R74Q|TMEM67_uc010mat.1_5'UTR|TMEM67_uc010maw.2_Missense_Mutation_p.R74Q|TMEM67_uc003yga.3_5'UTR	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	74					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			CAAGATGCCCGAGGTAAGACG	0.488			NA											5	121					0	0	0.001168	0	0
ABRA	137735	broad.mit.edu	37	8	107773358	107773358	+	Silent	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:107773358G>C	uc003ymm.3	-	2	1107	c.1053C>G	c.(1051-1053)CTC>CTG	p.L351L		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	351					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			TGGCACGCATGAGAATGCCCA	0.468			NA											4	184					0	0	0.000248	0	0
RSPO2	340419	broad.mit.edu	37	8	109001387	109001387	+	Missense_Mutation	SNP	G	G	C	rs149399382		TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:109001387G>C	uc003yms.2	-	3	838	c.180C>G	c.(178-180)TTC>TTG	p.F60L	RSPO2_uc003ymq.2_5'UTR|RSPO2_uc003ymr.2_Intron	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	60					Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			GAAGGAAGAAGAACAACTTCT	0.463			NA											6	54					0	0	0.001168	0	0
TRHR	7201	broad.mit.edu	37	8	110131366	110131366	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:110131366C>T	uc003ymz.3	+	2	895	c.879C>T	c.(877-879)TCC>TCT	p.S293S		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	293	Extracellular (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CATTTCTCTCCAGTCCTTTCC	0.423			NA											24	247					0	0	0.003954	0	0
ADCY8	114	broad.mit.edu	37	8	132052045	132052045	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr8:132052045G>A	uc003ytd.3	-	1	791	c.535C>T	c.(535-537)CGC>TGC	p.R179C	ADCY8_uc010mds.2_Missense_Mutation_p.R179C	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	179	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCCGATTTGCGCCTTTGGCCC	0.567			NA								HNSCC(32;0.087)			14	62					0	0	0.004007	0	0
TLN1	7094	broad.mit.edu	37	9	35706061	35706061	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:35706061C>T	uc003zxt.2	-	41	5763	c.5409G>A	c.(5407-5409)ATG>ATA	p.M1803I		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1803	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CGGCCTCGGTCATCATCTGCA	0.607			NA											16	103					0	0	0.004007	0	0
GCNT1	2650	broad.mit.edu	37	9	79118113	79118113	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:79118113C>G	uc010mpf.2	+	3	1157	c.816C>G	c.(814-816)GTC>GTG	p.V272V	GCNT1_uc010mpg.2_Silent_p.V272V|GCNT1_uc010mph.2_Silent_p.V272V|GCNT1_uc004akf.3_Silent_p.V272V|GCNT1_uc010mpi.2_Silent_p.V272V|GCNT1_uc004akh.3_Silent_p.V272V	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	272	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						CAGGGACTGTCAAAATGCTTC	0.458			NA											9	91					0	0	0.008291	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608772	84608772	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:84608772G>C	uc004amn.2	+	4	3434	c.3387G>C	c.(3385-3387)AAG>AAC	p.K1129N		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1129						integral to membrane					0						CATGGGATAAGAGAAAGAGTT	0.468			NA											7	62					0	0	0.00308	0	0
HNRNPK	3190	broad.mit.edu	37	9	86587088	86587088	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:86587088C>T	uc004ang.3	-	11	886	c.662G>A	c.(661-663)CGT>CAT	p.R221H	HNRNPK_uc011lsw.1_Translation_Start_Site|HNRNPK_uc004and.3_Translation_Start_Site|HNRNPK_uc004ank.3_Missense_Mutation_p.R221H|HNRNPK_uc004anf.3_Missense_Mutation_p.R221H|HNRNPK_uc004anh.3_Missense_Mutation_p.R197H|HNRNPK_uc011lsx.1_Missense_Mutation_p.R197H|HNRNPK_uc004ani.3_Missense_Mutation_p.R221H|HNRNPK_uc004anj.3_Missense_Mutation_p.R221H|HNRNPK_uc004ann.3_Missense_Mutation_p.R197H|HNRNPK_uc004anl.3_Missense_Mutation_p.R221H|HNRNPK_uc004anm.3_Missense_Mutation_p.R221H|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	221	5 X 4 AA repeats of G-X-G-G.|Necessary for interaction with DDX1.|2 X 22 AA approximate repeats.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						AGGCTGTGCACGTCCTTTGAT	0.418			NA											6	41					0	0	0.001984	0	0
ASPN	54829	broad.mit.edu	37	9	95222019	95222019	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:95222019G>A	uc004ase.1	-	7	1084	c.840C>T	c.(838-840)ATC>ATT	p.I280I	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_Intron	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	280	LRR 7.				bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0						TCCCATTTTCGATATCTGTGA	0.323			NA											4	20					0	0	0.000248	0	0
TDRD7	23424	broad.mit.edu	37	9	100245169	100245169	+	Silent	SNP	T	T	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:100245169T>C	uc004axj.2	+	15	2676	c.2451T>C	c.(2449-2451)GTT>GTC	p.V817V	TDRD7_uc011lux.1_Silent_p.V743V|TDRD7_uc010msp.1_Silent_p.V69V|TDRD7_uc011luy.1_Silent_p.V137V	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	817					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				TCGCACATGTTTATTTATTTA	0.368			NA											15	69					0	0	0.003163	0	0
RC3H2	54542	broad.mit.edu	37	9	125642152	125642152	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:125642152T>G	uc010mwc.1	-	8	1335	c.1094A>C	c.(1093-1095)GAC>GCC	p.D365A	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.D365A|RC3H2_uc004bne.3_Missense_Mutation_p.D365A|RC3H2_uc011lzf.1_Missense_Mutation_p.D102A|RC3H2_uc011lzg.1_Missense_Mutation_p.D365A	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	365						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						TGAAACAGCGTCTAAAATAAG	0.398			NA											4	41					0	0	0.000248	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070915	141070915	+	Silent	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:141070915C>G	uc004com.2	+	4	579	c.318C>G	c.(316-318)ACC>ACG	p.T106T	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TGTCAGACACCGTGGTGGAGC	0.522			NA											5	84					0	0	0.001168	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071097	141071097	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr9:141071097G>A	uc004com.2	+	4	761	c.500G>A	c.(499-501)TGC>TAC	p.C167Y	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						GTCACCACGTGCCTGCGCTTC	0.577			NA											6	45					0	0	0.001984	0	0
TLR7	51284	broad.mit.edu	37	X	12904782	12904782	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chrX:12904782G>C	uc004cvc.2	+	3	1294	c.1155G>C	c.(1153-1155)TTG>TTC	p.L385F		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	385	Extracellular (Potential).|LRR 13.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TTAAAGAGTTGAAAAGCTTTA	0.348			NA											9	128					0	0	0.008291	0	0
TRO	7216	broad.mit.edu	37	X	54955044	54955044	+	Silent	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chrX:54955044G>A	uc004dtq.2	+	12	1994	c.1887G>A	c.(1885-1887)AAG>AAA	p.K629K	TRO_uc004dts.2_Silent_p.K629K|TRO_uc004dtr.2_Silent_p.K629K|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Silent_p.K232K|TRO_uc011mok.1_Silent_p.K160K|TRO_uc004dtw.2_Silent_p.K232K|TRO_uc004dtx.2_Silent_p.K12K	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	629	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						AGGTGCAGAAGAAAGACCCCA	0.333			NA											9	102					0	0	0.004482	0	0
EFNB1	1947	broad.mit.edu	37	X	68060218	68060218	+	Silent	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chrX:68060218C>T	uc004dxd.3	+	5	1542	c.762C>T	c.(760-762)ATC>ATT	p.I254I	EFNB1_uc004dxe.2_Silent_p.I254I	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	254	Helical; (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						TCCTGCTCATCATCATCTTCC	0.617			NA											7	33					0	0	0.001984	0	0
ARMCX6	54470	broad.mit.edu	37	X	100871496	100871496	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chrX:100871496C>G	uc004ehx.2	-	3	460	c.115G>C	c.(115-117)GAG>CAG	p.E39Q	ARMCX6_uc004ehy.2_Missense_Mutation_p.E39Q	NM_019007	NP_061880	Q7L4S7	ARMX6_HUMAN	armadillo repeat containing, X-linked 6	39						integral to membrane					0						tccccctcctcctccagcttc	0.348			NA											6	37					0	0	0.001984	0	0
GPR112	139378	broad.mit.edu	37	X	135405147	135405147	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chrX:135405147G>A	uc004ezu.1	+	5	572	c.281G>A	c.(280-282)GGA>GAA	p.G94E	GPR112_uc010nsb.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	94	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GGACTTGCAGGAGACCATCAG	0.433			NA											20	132					0	0	0.001523	0	0
VMA21	203547	broad.mit.edu	37	X	150572114	150572114	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chrX:150572114C>T	uc004feu.2	+	2	141	c.65C>T	c.(64-66)TCA>TTA	p.S22L		NM_001017980	NP_001017980	Q3ZAQ7	VMA21_HUMAN	VMA21 vacuolar H+-ATPase homolog	22					vacuolar proton-transporting V-type ATPase complex assembly	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane|lysosome					0						AATGAAAGCTCATTAGCATCT	0.353			NA											23	179					0	0	0.00278	0	0
PAQR6	79957	broad.mit.edu	37	1	156214968	156214969	+	Frame_Shift_Ins	INS	-	-	ATAGGCT			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr1:156214968_156214969insATAGGCT	uc001fnu.1	-	6	643_644	c.573_574insAGCCTAT	c.(571-576)TATCCAfs	p.Y191fs	PAQR6_uc010phf.1_Frame_Shift_Ins_p.I58fs|PAQR6_uc001fny.1_5'UTR|PAQR6_uc001fnv.1_Frame_Shift_Ins_p.Y167fs|PAQR6_uc010phg.1_Frame_Shift_Ins_p.Y188fs|PAQR6_uc001fnx.1_Frame_Shift_Ins_p.Y85fs|PAQR6_uc001fnw.1_Frame_Shift_Ins_p.Y85fs|PAQR6_uc001fnz.1_Frame_Shift_Ins_p.Y85fs|PAQR6_uc010phh.1_Frame_Shift_Ins_p.Y191fs|PAQR6_uc001foa.1_Frame_Shift_Ins_p.Y85fs|PAQR6_uc001fob.1_RNA	NM_198406	NP_940798	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	191_192	Cytoplasmic (Potential).					integral to membrane	receptor activity				0	Hepatocellular(266;0.158)					AACAGGAATGGATAGGCGAAGG	0.604	GBM(16;219 398 12385 32425 38531)		NA											9	103	---	---	---	---	NA	NA	NA	NA	NA
KNDC1	85442	broad.mit.edu	37	10	135009286	135009286	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr10:135009286delC	uc001llz.1	+	10	1696	c.1695delC	c.(1693-1695)CGCfs	p.R565fs	KNDC1_uc001lma.1_Frame_Shift_Del_p.R500fs|KNDC1_uc001lmb.1_5'Flank	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	565	KIND 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TGGCCAGGCGCAGTGCCCCGG	0.692			NA											3	5	---	---	---	---	NA	NA	NA	NA	NA
KCNQ1	3784	broad.mit.edu	37	11	2869199	2869199	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr11:2869199delC	uc001lwn.2	+	16	2105	c.1997delC	c.(1996-1998)ACCfs	p.T666fs	KCNQ1_uc001lwo.2_Frame_Shift_Del_p.T539fs	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	666	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	GAGCAGCTGACCGTGCCCAGG	0.716			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
VPS33A	65082	broad.mit.edu	37	12	122729162	122729162	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr12:122729162delC	uc001ucd.2	-	7	1036	c.923delG	c.(922-924)GGCfs	p.G308fs	VPS33A_uc001ucc.2_RNA	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	308					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		GAGCACAGAGCCAACTGCGTT	0.507			NA											16	69	---	---	---	---	NA	NA	NA	NA	NA
GRIN2A	2903	broad.mit.edu	37	16	10274229	10274229	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr16:10274229delC	uc002czo.3	-	2	588	c.40delG	c.(40-42)GCCfs	p.A14fs	GRIN2A_uc010uym.1_Frame_Shift_Del_p.A14fs|GRIN2A_uc002czr.3_Frame_Shift_Del_p.A14fs|GRIN2A_uc010buk.2_Frame_Shift_Del_p.A14fs	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	14					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACCAGAAGGGCCGGCAGCACC	0.677			NA											7	35	---	---	---	---	NA	NA	NA	NA	NA
ANKFN1	162282	broad.mit.edu	37	17	54452001	54452002	+	In_Frame_Ins	INS	-	-	CAG			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr17:54452001_54452002insCAG	uc002iun.1	+	7	880_881	c.845_846insCAG	c.(844-846)ACC>ACCAGC	p.284_285insS		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	284_285	Fibronectin type-III.									large_intestine(1)|ovary(1)	2						CTCATGGTAACCAGCAGCACAT	0.46			NA											42	231	---	---	---	---	NA	NA	NA	NA	NA
CPXM1	56265	broad.mit.edu	37	20	2779492	2779492	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr20:2779492delC	uc002wgu.2	-	2	284	c.220delG	c.(220-222)GTCfs	p.V74fs	CPXM1_uc010gas.2_Frame_Shift_Del_p.V74fs	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	74					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						TTCATAATGACCTTTTTCTTC	0.577			NA											28	121	---	---	---	---	NA	NA	NA	NA	NA
MYH9	4627	broad.mit.edu	37	22	36696948	36696950	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	CTC	CTC	-	-	CTC	CTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr22:36696948_36696950delCTC	uc003apg.2	-	22	3016_3018	c.2785_2787delGAG	c.(2785-2787)GAGdel	p.E929del	MYH9_uc003aph.1_In_Frame_Del_p.E793del	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	929	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GCTGGCAGCGCTCCTCCTCCTCC	0.665			NA	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				7	139	---	---	---	---	NA	NA	NA	NA	NA
KIAA0947	23379	broad.mit.edu	37	5	5461386	5461388	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	TCT	TCT	-	-	TCT	TCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr5:5461386_5461388delTCT	uc003jdm.3	+	13	2161_2163	c.1939_1941delTCT	c.(1939-1941)TCTdel	p.S649del		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	649										ovary(1)|central_nervous_system(1)	2						TAATCCCCAGTCTTCTTCTGGGT	0.389			NA											9	205	---	---	---	---	NA	NA	NA	NA	NA
EXOC2	55770	broad.mit.edu	37	6	637794	637794	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr6:637794delG	uc003mtd.2	-	2	159	c.25delC	c.(25-27)CTTfs	p.L9fs	EXOC2_uc003mte.2_Frame_Shift_Del_p.L9fs|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	9	IPT/TIG.				exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		CCGGTCACAAGGGGGGGTTGT	0.483			NA											25	209	---	---	---	---	NA	NA	NA	NA	NA
INHBA	3624	broad.mit.edu	37	7	41729440	41729440	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:41729440delC	uc003thq.2	-	2	1324	c.1089delG	c.(1087-1089)GGGfs	p.G363fs	INHBA_uc003thr.2_Frame_Shift_Del_p.G363fs	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	363					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						ACAGTGAGGACCCGGACGTGC	0.567			NA								TSP Lung(11;0.080)			13	92	---	---	---	---	NA	NA	NA	NA	NA
MET	4233	broad.mit.edu	37	7	116412042	116412047	+	Splice_Site	DEL	AGGTAT	AGGTAT	-			TCGA-55-6982-01A-11D-1945-08	TCGA-55-6982-11A-01D-1945-08	AGGTAT	AGGTAT	-	-	AGGTAT	AGGTAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b7f11036-7ac4-41bc-a9a4-64162725fdfc	48a02a49-e77f-4a18-a2a2-3e28f13b25da	g.chr7:116412042_116412047delAGGTAT	uc003vij.2	+	14	3215	c.3028_splice	c.e14+1	p.D1010_splice	MET_uc010lkh.2_Splice_Site_p.D1028_splice|MET_uc011knj.1_Splice_Site_p.D580_splice	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor						axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.982_1028del47(4)|p.L982_D1028del(3)|p.?(3)|p.D981_D1028del(1)		upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CTTTTCCAGAAGGTATATTTCAGTTT	0.35			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				7	49	---	---	---	---	NA	NA	NA	NA	NA