Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CATSPER4	378807	broad.mit.edu	37	1	26520352	26520352	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:26520352G>T	uc010oez.1	+	3	432	c.432G>T	c.(430-432)TGG>TGT	p.W144C	CATSPER4_uc010oey.1_5'UTR|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	144	Helical; Name=Segment S2; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTTGGCTGGCTCAATGGCT	0.507			NA											14	95					1.3612e-06	1.65116e-06	0.003163	1	0
ARID1A	8289	broad.mit.edu	37	1	27099440	27099440	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:27099440A>G	uc001bmv.1	+	14	4050	c.3677A>G	c.(3676-3678)TAT>TGT	p.Y1226C	ARID1A_uc001bmt.1_Missense_Mutation_p.Y1225C|ARID1A_uc001bmu.1_Missense_Mutation_p.Y1226C|ARID1A_uc001bmw.1_Missense_Mutation_p.Y843C|ARID1A_uc001bmx.1_Missense_Mutation_p.Y72C|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1226					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.M1220fs*9(1)|p.M1220fs*2(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CGCATGTCCTATGAGCCAAAT	0.488			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								23	58					0	0	0.00333	0	0
RABGGTB	5876	broad.mit.edu	37	1	76253189	76253189	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:76253189C>G	uc001dgy.1	+	2	82	c.11C>G	c.(10-12)CCA>CGA	p.P4R	RABGGTB_uc009wbt.1_RNA|RABGGTB_uc001dha.1_5'UTR|SNORD45A_uc009wbu.1_5'Flank|SNORD45B_uc009wbv.1_5'Flank	NM_004582	NP_004573	P53611	PGTB2_HUMAN	RAB geranylgeranyltransferase, beta subunit	4					protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			ovary(1)	1						AAGGGCACTCCACAGAAGGAT	0.378			NA											9	50					0	0	0.006214	0	0
TTLL7	79739	broad.mit.edu	37	1	84412840	84412840	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:84412840A>G	uc001djc.2	-	6	869	c.473T>C	c.(472-474)ATA>ACA	p.I158T	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	158	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TGGTTTCACTATAAAAGTTTT	0.328			NA											11	35					0	0	0.001368	0	0
TTLL7	79739	broad.mit.edu	37	1	84415555	84415555	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:84415555T>A	uc001djc.2	-	4	668	c.272A>T	c.(271-273)AAT>ATT	p.N91I	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	91	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TACCTGATAATTTTGCAGCTC	0.338			NA											6	45					0	0	0.001168	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448933	89448933	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:89448933G>C	uc009wcx.2	-	3	1293	c.577C>G	c.(577-579)CCA>GCA	p.P193A	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.P193A	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	193							nucleotide binding|RNA binding				0						CTTCGAGGTGGACCTCCATAA	0.488			NA											4	131					0	0	0.009096	0	0
VCAM1	7412	broad.mit.edu	37	1	101186081	101186081	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:101186081G>A	uc001dti.2	+	2	234	c.114G>A	c.(112-114)CAG>CAA	p.Q38Q	VCAM1_uc001dtj.2_Silent_p.Q38Q|VCAM1_uc010ouj.1_Silent_p.Q38Q	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	38	Ig-like C2-type 1.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	ATCTTGCTCAGATTGGTGACT	0.433			NA											9	74					0	0	0.010729	0	0
GJA5	2702	broad.mit.edu	37	1	147230556	147230556	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:147230556G>T	uc001eps.1	-	2	932	c.791C>A	c.(790-792)CCC>CAC	p.P264H	GJA5_uc001ept.1_Missense_Mutation_p.P264H	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	264	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			AAAGTCGGGGGGTGGTGTGCA	0.527			NA											18	98					5.03518e-11	6.9276e-11	0.007413	1	0
FLG	2312	broad.mit.edu	37	1	152278958	152278958	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:152278958G>A	uc001ezu.1	-	3	8440	c.8404C>T	c.(8404-8406)CAC>TAC	p.H2802Y		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2802	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAATGCTCGTGGTGGTACCCC	0.607			NA							Ichthyosis				64	607					0	0	0.00361	0	0
FLG	2312	broad.mit.edu	37	1	152280504	152280504	+	Silent	SNP	G	G	A	rs141571186		TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:152280504G>A	uc001ezu.1	-	3	6894	c.6858C>T	c.(6856-6858)CAC>CAT	p.H2286H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2286	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTGTCTTCGTGATGGGACC	0.557			NA							Ichthyosis				42	659					0	0	0.00361	0	0
TRIM46	80128	broad.mit.edu	37	1	155150586	155150586	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:155150586C>A	uc001fhs.1	+	6	1101	c.1018C>A	c.(1018-1020)CAG>AAG	p.Q340K	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.Q340K|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.Q214K|TRIM46_uc001fhu.1_Missense_Mutation_p.Q317K|TRIM46_uc009wpg.1_Missense_Mutation_p.Q327K|TRIM46_uc001fhv.3_Missense_Mutation_p.Q327K|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	340	Potential.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGAATGCCAGCAGGAGCGGCT	0.637			NA											21	50					3.51602e-12	4.93687e-12	0.008871	1	0
ARHGEF11	9826	broad.mit.edu	37	1	156926306	156926306	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:156926306C>T	uc001fqo.2	-	18	2497	c.1457G>A	c.(1456-1458)CGT>CAT	p.R486H	ARHGEF11_uc001fqn.2_Missense_Mutation_p.R526H|ARHGEF11_uc001fqp.1_Missense_Mutation_p.R15H	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	486	RGSL.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTCTCGAAGACGGATCCCAGC	0.527			NA											13	172					0	0	0.001855	0	0
BLZF1	8548	broad.mit.edu	37	1	169349788	169349788	+	Silent	SNP	T	T	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:169349788T>C	uc001gfx.1	+	5	1175	c.738T>C	c.(736-738)GCT>GCC	p.A246A	BLZF1_uc001gfy.2_Silent_p.A246A|BLZF1_uc009wvp.1_Silent_p.A223A	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	246					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					CACACGGGGCTATACAAGATC	0.403			NA											4	81					0	0	0.009096	0	0
PRG4	10216	broad.mit.edu	37	1	186276429	186276429	+	Silent	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:186276429C>T	uc001gru.3	+	7	1629	c.1578C>T	c.(1576-1578)ACC>ACT	p.T526T	PRG4_uc001grt.3_Silent_p.T485T|PRG4_uc009wyl.2_Silent_p.T433T|PRG4_uc009wym.2_Silent_p.T392T|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	526	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|23.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CACCCACCACCACCAAGTCTG	0.637			NA											4	131					0	0	0.009096	0	0
CACNA1S	779	broad.mit.edu	37	1	201029913	201029913	+	Missense_Mutation	SNP	C	C	T	rs142102094	by1000genomes	TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:201029913C>T	uc001gvv.2	-	26	3514	c.3287G>A	c.(3286-3288)CGC>CAC	p.R1096H		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1096	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCTCAGTGGGCGGGCCTTCAG	0.532			NA											5	368					0	0	0.001168	0	0
RYR2	6262	broad.mit.edu	37	1	237947181	237947181	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:237947181C>G	uc001hyl.1	+	90	12289	c.12169C>G	c.(12169-12171)CAC>GAC	p.H4057D	RYR2_uc010pya.1_Missense_Mutation_p.H472D	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4057	EF-hand.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGCCATAAGCACTACACGCA	0.468			NA											5	23					0	0	0.000602	0	0
CHRM3	1131	broad.mit.edu	37	1	240071045	240071045	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:240071045G>T	uc001hyp.2	+	5	1073	c.294G>T	c.(292-294)CAG>CAT	p.Q98H		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	98	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TCAACAAGCAGCTGAAGACGG	0.468			NA											17	36					2.4624e-09	3.25672e-09	0.008871	1	0
OR6F1	343169	broad.mit.edu	37	1	247875362	247875362	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:247875362A>T	uc001idj.1	-	1	696	c.696T>A	c.(694-696)AGT>AGA	p.S232R		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGCTCCGGCCACTGGCAGAGG	0.522			NA											13	98					0	0	0.001368	0	0
OR14C36	127066	broad.mit.edu	37	1	248512610	248512610	+	Silent	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr1:248512610C>T	uc010pzl.1	+	1	534	c.534C>T	c.(532-534)GAC>GAT	p.D178D		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCTTCTGTGACATCCCCTCTC	0.512			NA											24	61					0	0	0.00632	0	0
CDH23	64072	broad.mit.edu	37	10	73544152	73544152	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:73544152G>A	uc001jrx.3	+	40	5854	c.5477G>A	c.(5476-5478)CGG>CAG	p.R1826Q		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1826	Cadherin 17.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GCCCGTGACCGGGGGATGCCC	0.617			NA											10	60					0	0	0.010729	0	0
SH2D4B	387694	broad.mit.edu	37	10	82329944	82329944	+	Silent	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:82329944G>T	uc001kck.1	+	2	649	c.219G>T	c.(217-219)GGG>GGT	p.G73G	SH2D4B_uc001kcl.1_Silent_p.G24G	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	72											0			Colorectal(32;0.229)			GGCTCCTAGGGGCAGATGGCG	0.517			NA											24	102					4.47668e-21	6.84865e-21	0.003954	1	0
RNLS	55328	broad.mit.edu	37	10	90342049	90342049	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:90342049G>C	uc001kfe.2	-	2	269	c.134C>G	c.(133-135)ACA>AGA	p.T45R	RNLS_uc010qms.1_Intron|RNLS_uc001kfd.2_Missense_Mutation_p.T45R	NM_001031709	NP_001026879	Q5VYX0	RNLS_HUMAN	renalase isoform 1	45						extracellular region	oxidoreductase activity			ovary(1)	1						ACTGCAGGCTGTAGTCATTCT	0.443			NA											7	28					0	0	0.001984	0	0
SLIT1	6585	broad.mit.edu	37	10	98807524	98807524	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:98807524A>T	uc001kmw.2	-	16	1809	c.1557T>A	c.(1555-1557)TGT>TGA	p.C519*	SLIT1_uc009xvh.1_Nonsense_Mutation_p.C529*	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	519	LRRNT 3.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CGTTGGCCTCACAGCGGCACT	0.642			NA											20	55					0	0	0.008871	0	0
WNT8B	7479	broad.mit.edu	37	10	102242322	102242322	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:102242322G>A	uc001krb.2	+	6	919	c.805G>A	c.(805-807)GGC>AGC	p.G269S		NM_003393	NP_003384	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family,	269					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(1)|breast(1)|large_intestine(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		GGGCACCGAAGGCCGAGAGTG	0.706			NA									OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	17					0	0	0.004672	0	0
SUFU	51684	broad.mit.edu	37	10	104356990	104356990	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:104356990G>T	uc001kvy.1	+	7	996	c.850G>T	c.(850-852)GAT>TAT	p.D284Y	SUFU_uc001kvw.1_Missense_Mutation_p.D284Y|SUFU_uc001kvx.2_Missense_Mutation_p.D284Y|SUFU_uc009xxe.1_RNA|SUFU_uc009xxf.1_RNA	NM_016169	NP_057253	Q9UMX1	SUFU_HUMAN	suppressor of fused	284					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			central_nervous_system(4)|skin(2)|breast(1)	7		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		GCCCCCCGAGGATGACGAGGA	0.607			NA	D|F|S		medulloblastoma	medulloblastoma			Medulloblastoma_associated_with_Germline_SUFU_Mutation		OREG0020482	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	127					5.50884e-06	6.56577e-06	0.001368	1	0
SLK	9748	broad.mit.edu	37	10	105770586	105770586	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:105770586G>A	uc001kxo.1	+	13	2831	c.2797G>A	c.(2797-2799)GTG>ATG	p.V933M	SLK_uc001kxp.1_Intron	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	933	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TATAAATGAAGTGGAGAAAGC	0.438	NSCLC(111;540 1651 1927 4474 17706)		NA											5	35					0	0	0.001168	0	0
DMBT1	1755	broad.mit.edu	37	10	124353097	124353097	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr10:124353097G>A	uc001lgk.1	+	21	2619	c.2513G>A	c.(2512-2514)CGG>CAG	p.R838Q	DMBT1_uc001lgl.1_Missense_Mutation_p.R828Q|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.R838Q|DMBT1_uc010qtx.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	838					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCCCAGTCCCGGCCGACACCC	0.522	Ovarian(182;93 2026 18125 22222 38972)		NA											53	347					0	0	0.00361	0	0
OSBPL5	114879	broad.mit.edu	37	11	3125497	3125497	+	Silent	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:3125497G>T	uc001lxk.2	-	10	1328	c.1170C>A	c.(1168-1170)CCC>CCA	p.P390P	OSBPL5_uc010qxq.1_Silent_p.P301P|OSBPL5_uc009ydw.2_Silent_p.P322P|OSBPL5_uc001lxl.2_Silent_p.P322P|OSBPL5_uc009ydx.2_Silent_p.P414P	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	390					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GTACGAACGTGGGTAGCACCA	0.627			NA											8	68					0.000157383	0.000183316	0.00308	1	0
ART5	116969	broad.mit.edu	37	11	3660985	3660985	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:3660985G>A	uc001lyb.1	-	2	1067	c.674C>T	c.(673-675)CCC>CTC	p.P225L	ART5_uc001lyc.1_Missense_Mutation_p.P225L|ART5_uc001lyd.2_Intron|ART5_uc009yea.2_Intron	NM_053017	NP_443750	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5 precursor	225						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCATGGGGGGGAATCAGCAC	0.502			NA											5	99					0	0	0.001168	0	0
OR52A1	23538	broad.mit.edu	37	11	5172979	5172979	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:5172979G>A	uc010qyy.1	-	1	621	c.621C>T	c.(619-621)TTC>TTT	p.F207F		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGCTACAGTGAAGGCCACAA	0.423			NA											16	101					0	0	0.004007	0	0
ILK	3611	broad.mit.edu	37	11	6631242	6631242	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:6631242G>C	uc001mee.2	+	11	1189	c.1054G>C	c.(1054-1056)GCA>CCA	p.A352P	ILK_uc001mef.2_Missense_Mutation_p.A352P|ILK_uc010rap.1_Missense_Mutation_p.A218P|ILK_uc010raq.1_Missense_Mutation_p.A291P|ILK_uc001meg.2_Missense_Mutation_p.A198P|ILK_uc001meh.2_Missense_Mutation_p.A352P|ILK_uc001mei.2_5'Flank	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	352	Protein kinase.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		TCGCATGTATGCACCTGCCTG	0.507			NA											3	70					0	0	0.000602	0	0
SPON1	10418	broad.mit.edu	37	11	14101549	14101549	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:14101549C>A	uc001mle.2	+	6	1196	c.658C>A	c.(658-660)CAC>AAC	p.H220N		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	220	Spondin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		CGAGAAGACACACCCAAAGGA	0.488			NA											10	52					4.68919e-08	5.97071e-08	0.008291	1	0
RAG2	5897	broad.mit.edu	37	11	36614887	36614887	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:36614887G>A	uc001mwv.3	-	2	1020	c.832C>T	c.(832-834)CAG>TAG	p.Q278*	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	278					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TTTTCAAGCTGATAGCCACCA	0.423			NA							Familial_Hemophagocytic_Lymphohistiocytosis				6	75					0	0	0.001984	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798753	55798753	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:55798753C>A	uc010riw.1	+	1	859	c.859C>A	c.(859-861)CCA>ACA	p.P287T		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					CATGTTTAATCCAATAATTTA	0.343			NA											4	30					1.024e-07	1.2958e-07	0.000602	1	0
OR8H1	219469	broad.mit.edu	37	11	56058115	56058115	+	Missense_Mutation	SNP	C	C	A	rs142532321		TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:56058115C>A	uc010rje.1	-	1	424	c.424G>T	c.(424-426)GCT>TCT	p.A142S		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GTGACAAGAGCGCAACACAGC	0.443			NA											10	47					1.76689e-08	2.27807e-08	0.006214	1	0
GPHA2	170589	broad.mit.edu	37	11	64702312	64702312	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:64702312C>T	uc001oca.2	-	4	378	c.323G>A	c.(322-324)AGG>AAG	p.R108K		NM_130769	NP_570125	Q96T91	GPHA2_HUMAN	glycoprotein hormone alpha 2 precursor	108						extracellular region	hormone activity				0						GAGCTCCTCCCTCCGGCTCCC	0.617			NA											21	68					0	0	0.012319	0	0
SHANK2	22941	broad.mit.edu	37	11	70319334	70319334	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:70319334G>A	uc001oqc.2	-	22	5268	c.5190C>T	c.(5188-5190)ACC>ACT	p.T1730T	SHANK2_uc010rqn.1_Silent_p.T1142T|SHANK2_uc001opz.2_Silent_p.T1135T|uc009ysn.1_Intron|SHANK2_uc001opy.2_Silent_p.T66T	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1351					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AAGGAGAGGCGGTGGCAGCAG	0.597			NA											16	99					0	0	0.003163	0	0
FAM168A	23201	broad.mit.edu	37	11	73141755	73141755	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:73141755T>A	uc001otz.1	-	3	410	c.131A>T	c.(130-132)AAT>ATT	p.N44I	FAM168A_uc001oty.1_Missense_Mutation_p.N44I|FAM168A_uc009ytp.1_Missense_Mutation_p.N44I	NM_015159	NP_055974	Q92567	F168A_HUMAN	hypothetical protein LOC23201	44											0						ACTGGGACTATTGGTGGGGTA	0.502			NA											53	106					0	0	0.00361	0	0
ATM	472	broad.mit.edu	37	11	108128265	108128265	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:108128265G>T	uc001pkb.1	+	15	2693	c.2308G>T	c.(2308-2310)GAA>TAA	p.E770*	ATM_uc009yxr.1_Nonsense_Mutation_p.E770*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	770					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.E770*(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GACAAATGAGGAATTCAGAAT	0.299			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			21	48					3.01185e-09	3.95788e-09	0.003954	1	0
OR8D4	338662	broad.mit.edu	37	11	123777637	123777637	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:123777637T>A	uc010saa.1	+	1	499	c.499T>A	c.(499-501)TCT>ACT	p.S167T		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		ACTCAGGTTGTCTTTCTGTGG	0.423			NA											16	184					0	0	0.004007	0	0
WNT5B	81029	broad.mit.edu	37	12	1755170	1755170	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr12:1755170C>G	uc009zdq.2	+	5	1074	c.832C>G	c.(832-834)CTG>GTG	p.L278V	WNT5B_uc001qjj.2_Missense_Mutation_p.L278V|WNT5B_uc001qjk.2_Missense_Mutation_p.L278V|WNT5B_uc001qjl.2_Missense_Mutation_p.L278V	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	278					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			CCCGGAGGACCTGGTCTATGT	0.687			NA											14	44					0	0	0.003163	0	0
WBP11	51729	broad.mit.edu	37	12	14947586	14947586	+	Silent	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr12:14947586A>G	uc001rci.2	-	7	767	c.606T>C	c.(604-606)CCT>CCC	p.P202P		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	202	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						GACCAGGGGGAGGGCCAGGAG	0.512			NA											3	192					0	0	0.009096	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18716397	18716397	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr12:18716397A>C	uc001rdt.2	+	27	3860	c.3744A>C	c.(3742-3744)CAA>CAC	p.Q1248H	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.Q1289H|PIK3C2G_uc010sic.1_Missense_Mutation_p.Q1067H	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1248	PX.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TTCACAGCCAACTTCAGAAGC	0.403			NA											4	79					0	0	0.009096	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	30					0.000442599	0.000504071	0.006214	1	0
CCNT1	904	broad.mit.edu	37	12	49087591	49087591	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr12:49087591C>T	uc001rse.1	-	9	1729	c.1406G>A	c.(1405-1407)GGA>GAA	p.G469E	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.G184E	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	469					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						AGCTTTATCTCCACCTGCCAC	0.443			NA											23	72					0	0	0.00278	0	0
NAV3	89795	broad.mit.edu	37	12	78401192	78401192	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr12:78401192C>A	uc001syp.2	+	8	2047	c.1874C>A	c.(1873-1875)CCG>CAG	p.P625Q	NAV3_uc001syo.2_Missense_Mutation_p.P625Q	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	625						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CATAGCCACCCGAATACCGCG	0.478			NA								HNSCC(70;0.22)			26	122					1.17739e-12	1.68787e-12	0.005443	1	0
GALNT4	8693	broad.mit.edu	37	12	89916917	89916917	+	Silent	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr12:89916917A>G	uc001tbd.2	-	1	1619	c.1410T>C	c.(1408-1410)GCT>GCC	p.A470A	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Silent_p.A467A|GALNT4_uc010suo.1_Silent_p.A162A	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	470	Ricin B-type lectin.|Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						GTGAAAGGTTAGCACCTGTGG	0.418			NA											18	53					0	0	0.006122	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679151	37679151	+	Silent	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr13:37679151C>T	uc001uwm.1	-	1	651	c.243G>A	c.(241-243)CAG>CAA	p.Q81Q		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	81	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		TGTCTTTTTCCTGACCATACC	0.468			NA											17	68					0	0	0.00499	0	0
OR4L1	122742	broad.mit.edu	37	14	20528750	20528750	+	Missense_Mutation	SNP	C	C	A	rs35605617		TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:20528750C>A	uc001vwn.1	+	1	547	c.547C>A	c.(547-549)CTT>ATT	p.L183I		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TGATCTTCCCCTTGTGATCAA	0.398			NA											17	200					1.33834e-09	1.78155e-09	0.007413	1	0
TMEM55B	90809	broad.mit.edu	37	14	20926775	20926775	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:20926775G>A	uc001vxl.2	-	7	930	c.777C>T	c.(775-777)GGC>GGT	p.G259G	TMEM55B_uc001vxk.2_Silent_p.G266G	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	259	Helical; (Potential).					integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		AAAGAGCCCGGCCCAAACACA	0.562			NA											3	55					0	0	0.009096	0	0
MYH7	4625	broad.mit.edu	37	14	23886428	23886429	+	Nonsense_Mutation	DNP	TG	TG	AA	rs61737803	byFrequency	TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:23886428_23886429TG>AA	uc001wjx.2	-	32	4558_4559	c.4452_4453CA>TT	c.(4450-4455)CTCAAG>CTTTAG	p.K1485*		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1485	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TAGGCGTTCTTGAGTTTGAAGA	0.589			NA											18	157					0	0	0.004672	0	0
C14orf182	283551	broad.mit.edu	37	14	50458973	50458973	+	Splice_Site	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:50458973C>A	uc001wxi.1	-	3	2093	c.372_splice	c.e3+1			NM_001012706	NP_001012724	A1A4T8	CN182_HUMAN	hypothetical protein LOC283551												0						ATTCAACTTACCTCATTCATT	0.398			NA											25	84					1.04121e-07	1.3095e-07	0.005443	1	0
PELI2	57161	broad.mit.edu	37	14	56763464	56763464	+	Silent	SNP	G	G	A	rs139388844	byFrequency	TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:56763464G>A	uc001xch.2	+	6	1129	c.843G>A	c.(841-843)CGG>CGA	p.R281R		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	281					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding	p.R281Q(1)		ovary(1)	1						ACGCCGCCCGGCCTCAGTGTC	0.582			NA											13	33					0	0	0.00245	0	0
RHOJ	57381	broad.mit.edu	37	14	63735888	63735888	+	Splice_Site	SNP	T	T	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:63735888T>C	uc001xgb.1	+	2	680	c.237_splice	c.e2+2	p.Q79_splice		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor						actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		GCGGGACAGGTACATTTTTAT	0.398			NA											5	74					0	0	0.001984	0	0
SYNE2	23224	broad.mit.edu	37	14	64457753	64457753	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:64457753G>C	uc001xgm.2	+	21	2796	c.2566G>C	c.(2566-2568)GAA>CAA	p.E856Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E856Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	856	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATCCCAGAAGGAACTTGAATC	0.433			NA											27	50					0	0	0.007291	0	0
SMOC1	64093	broad.mit.edu	37	14	70480191	70480191	+	Silent	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:70480191G>T	uc001xls.1	+	10	1282	c.1029G>T	c.(1027-1029)GCG>GCT	p.A343A	SMOC1_uc001xlt.1_Silent_p.A343A	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	343					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ACTCAGCAGCGCCCACTGGAG	0.512			NA									OREG0022771	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	88					0.00829132	0.00889906	0.008291	1	0
ADAM21P1	145241	broad.mit.edu	37	14	70712645	70712645	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:70712645A>T	uc010ttg.1	-	1	1874	c.1223T>A	c.(1222-1224)TTT>TAT	p.F408Y		NR_003951				SubName: Full=ADAM21-like protein;												0						CTGCAAAGTAAAATGATCTTG	0.393			NA											25	84					0	0	0.003755	0	0
SPATA7	55812	broad.mit.edu	37	14	88897527	88897527	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:88897527A>T	uc001xwq.2	+	9	1191	c.1040A>T	c.(1039-1041)CAG>CTG	p.Q347L	SPATA7_uc001xwr.2_Missense_Mutation_p.Q315L|SPATA7_uc001xws.2_Missense_Mutation_p.Q283L|SPATA7_uc001xwt.2_Missense_Mutation_p.Q241L|SPATA7_uc001xwu.2_Missense_Mutation_p.Q3L	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	347					response to stimulus|visual perception					ovary(1)	1						GCAATGTGTCAGTATTCCCTG	0.264			NA											76	137					0	0	0.00361	0	0
DDX24	57062	broad.mit.edu	37	14	94526457	94526457	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:94526457C>A	uc001ycj.2	-	5	1999	c.1900G>T	c.(1900-1902)GCC>TCC	p.A634S	DDX24_uc010twq.1_Missense_Mutation_p.A591S|DDX24_uc010twr.1_Missense_Mutation_p.A384S	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	634	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding	p.A634A(1)		ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TCCAGACGGGCAAACTGCTCC	0.517			NA											26	51					1.1804e-14	1.74087e-14	0.003954	1	0
AHNAK2	113146	broad.mit.edu	37	14	105404423	105404423	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:105404423C>T	uc010axc.1	-	7	17485	c.17365G>A	c.(17365-17367)GGC>AGC	p.G5789S	AHNAK2_uc001ypx.2_Missense_Mutation_p.G5689S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5789						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTCCCAGGCCTGACCCTTTG	0.498			NA											11	46					0	0	0.003163	0	0
OCA2	4948	broad.mit.edu	37	15	28235784	28235784	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr15:28235784T>A	uc001zbh.3	-	10	1164	c.1054A>T	c.(1054-1056)AGA>TGA	p.R352*	OCA2_uc010ayv.2_Intron	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	352	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GCCAGAGTTCTGTGCACGATC	0.542			NA							Oculocutaneous_Albinism				28	129					0	0	0.005443	0	0
CAPN3	825	broad.mit.edu	37	15	42684893	42684893	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr15:42684893C>G	uc001zpn.1	+	7	1308	c.1002C>G	c.(1000-1002)CAC>CAG	p.H334Q	CAPN3_uc001zpk.1_Missense_Mutation_p.H107Q|CAPN3_uc001zpl.1_Missense_Mutation_p.H247Q|CAPN3_uc010udf.1_Missense_Mutation_p.H247Q|CAPN3_uc010udg.1_Missense_Mutation_p.H199Q|CAPN3_uc001zpo.1_Missense_Mutation_p.H334Q|CAPN3_uc001zpp.1_Missense_Mutation_p.H286Q	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	334	Calpain catalytic.	By similarity.	H -> Q (in LGMD2A).		muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		TCAGAGGTCACGCCTACTCTG	0.567			NA											12	36					0	0	0.001368	0	0
CDAN1	146059	broad.mit.edu	37	15	43021262	43021262	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr15:43021262G>A	uc001zql.2	-	19	2721	c.2604C>T	c.(2602-2604)TTC>TTT	p.F868F	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Silent_p.F194F	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	868			F -> I (in CDA1).			integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		TTTCTGCCACGAACTCTACGG	0.547			NA											15	117					0	0	0.004007	0	0
TPSD1	23430	broad.mit.edu	37	16	1306688	1306688	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:1306688C>T	uc002clb.1	+	2	263	c.254C>T	c.(253-255)CCG>CTG	p.P85L	TPSD1_uc010brm.1_Missense_Mutation_p.P23L	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	85	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TGCGTGGAACCGTGAGTCTCC	0.697			NA											6	52					0	0	0.00308	0	0
UNKL	64718	broad.mit.edu	37	16	1453292	1453292	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:1453292C>G	uc010bro.1	-	3	349	c.341G>C	c.(340-342)CGT>CCT	p.R114P	UNKL_uc002clq.2_Missense_Mutation_p.R114P	NM_001037125	NP_001032202	Q9H9P5	UNKL_HUMAN	unkempt homolog (Drosophila)-like isoform 2	114						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				TTTGTAGTAACGCAGGTGGTA	0.612			NA											8	26					0	0	0.006214	0	0
TFAP4	7023	broad.mit.edu	37	16	4310225	4310225	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:4310225T>G	uc010uxg.1	-	6	942	c.688A>C	c.(688-690)ACC>CCC	p.T230P		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	230	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GGGTGGTGGGTGGGGGCCGGA	0.622			NA											4	57					0	0	0.004482	0	0
A2BP1	54715	broad.mit.edu	37	16	7637286	7637286	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:7637286A>G	uc002cys.2	+	7	1440	c.452A>G	c.(451-453)AAT>AGT	p.N151S	A2BP1_uc010buf.1_Missense_Mutation_p.N151S|A2BP1_uc002cyr.1_Missense_Mutation_p.N150S|A2BP1_uc002cyt.2_Missense_Mutation_p.N151S|A2BP1_uc010uxz.1_Missense_Mutation_p.N194S|A2BP1_uc010uya.1_Missense_Mutation_p.N139S|A2BP1_uc002cyv.1_Missense_Mutation_p.N151S|A2BP1_uc010uyb.1_Missense_Mutation_p.N151S|A2BP1_uc002cyw.2_Missense_Mutation_p.N171S|A2BP1_uc002cyy.2_Missense_Mutation_p.N171S|A2BP1_uc002cyx.2_Missense_Mutation_p.N171S|A2BP1_uc010uyc.1_Missense_Mutation_p.N171S	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	151	RRM.	Interaction with RNA.			mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		ATTATTTTTAATGAGCGAGGC	0.289			NA											7	67					0	0	0.006214	0	0
IL4R	3566	broad.mit.edu	37	16	27374684	27374684	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:27374684C>T	uc002don.2	+	11	2253	c.2011C>T	c.(2011-2013)CCA>TCA	p.P671S	IL4R_uc002dop.3_Missense_Mutation_p.P656S|IL4R_uc010bxy.2_Missense_Mutation_p.P671S|IL4R_uc002doo.2_Missense_Mutation_p.P511S	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	671	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						CTCACATCTCCCAAGCAGCTC	0.642			NA											9	47					0	0	0.010729	0	0
ZNF423	23090	broad.mit.edu	37	16	49672130	49672130	+	Silent	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:49672130G>T	uc002efs.2	-	5	1231	c.933C>A	c.(931-933)CTC>CTA	p.L311L	ZNF423_uc010vgn.1_Silent_p.L194L	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	311	C2H2-type 7.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGATATGGGCGAGCAGTGTGT	0.607			NA											19	40					1.96292e-10	2.63006e-10	0.010504	1	0
NOD2	64127	broad.mit.edu	37	16	50756544	50756544	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:50756544A>T	uc002egm.1	+	8	2831	c.2726A>T	c.(2725-2727)AAC>ATC	p.N909I	NOD2_uc010cbl.1_Missense_Mutation_p.N659I|NOD2_uc010cbm.1_Missense_Mutation_p.N659I|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_RNA|NOD2_uc010cbq.1_Missense_Mutation_p.N47I|NOD2_uc010cbr.1_RNA|NOD2_uc010vgq.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	909	LRR 5.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				TTCTGGGGCAACAGAGTGGGT	0.527			NA											100	334					0	0	0.00361	0	0
GPR97	222487	broad.mit.edu	37	16	57717908	57717908	+	Silent	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:57717908C>T	uc002emh.2	+	9	1049	c.946C>T	c.(946-948)CTG>TTG	p.L316L	GPR97_uc010vhv.1_Silent_p.L196L|GPR97_uc010cdd.2_Intron|GPR97_uc010cde.2_Intron	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	316	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GGGTGGCAGCCTGTTCCTCCT	0.602			NA											26	57					0	0	0.003954	0	0
PMFBP1	83449	broad.mit.edu	37	16	72166806	72166806	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr16:72166806C>A	uc002fcc.3	-	10	1460	c.1288G>T	c.(1288-1290)GAG>TAG	p.E430*	PMFBP1_uc002fcd.2_Nonsense_Mutation_p.E430*|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Nonsense_Mutation_p.E285*	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	430	Potential.									ovary(2)	2		Ovarian(137;0.179)				TTCTCCAGCTCCTTCTCCTTT	0.512			NA											48	89					1.22102e-19	1.85414e-19	0.00361	1	0
GUCY2D	3000	broad.mit.edu	37	17	7910764	7910764	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr17:7910764A>G	uc002gjt.2	+	6	1558	c.1484A>G	c.(1483-1485)CAA>CGA	p.Q495R		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	495	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				CTTCACATGCAAATGGTCTCC	0.597			NA											20	121					0	0	0.00278	0	0
MYH3	4621	broad.mit.edu	37	17	10541609	10541609	+	Silent	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr17:10541609C>G	uc002gmq.1	-	26	3557	c.3480G>C	c.(3478-3480)ACG>ACC	p.T1160T		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1160	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GCTCTATCTGCGTGGAGGTGA	0.667			NA											18	45					0	0	0.008871	0	0
PPM1D	8493	broad.mit.edu	37	17	58711300	58711300	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr17:58711300T>C	uc002iyt.1	+	3	1010	c.788T>C	c.(787-789)ATT>ACT	p.I263T	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	263	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			AGCACAGTTATTGACCAGATT	0.378			NA											8	85					0	0	0.006214	0	0
TNRC6C	57690	broad.mit.edu	37	17	76046101	76046101	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr17:76046101G>A	uc002jud.2	+	4	1558	c.958G>A	c.(958-960)GTT>ATT	p.V320I	TNRC6C_uc002juf.2_Missense_Mutation_p.V320I|TNRC6C_uc002jue.2_Missense_Mutation_p.V320I	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	320	Sufficient for interaction with argonaute family proteins.|Gly-rich.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CAACAATGGCGTTGGTAATAT	0.557			NA											6	73					0	0	0.001984	0	0
CBX2	84733	broad.mit.edu	37	17	77758643	77758643	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr17:77758643G>A	uc002jxc.2	+	5	1443	c.1401G>A	c.(1399-1401)TCG>TCA	p.S467S		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	467	Poly-Ser.				cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GTAGCAGCTCGGACTCCGACC	0.682			NA											8	21					0	0	0.00308	0	0
DSG4	147409	broad.mit.edu	37	18	28991245	28991245	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr18:28991245C>G	uc002kwq.2	+	15	2324	c.2189C>G	c.(2188-2190)TCG>TGG	p.S730W	DSG4_uc002kwr.2_Missense_Mutation_p.S749W	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	730	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGAGGTGTATCGGGAGTGGAG	0.468			NA											29	93					0	0	0.002836	0	0
ASXL3	80816	broad.mit.edu	37	18	31324952	31324952	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr18:31324952A>C	uc010dmg.1	+	12	5195	c.5140A>C	c.(5140-5142)AGT>CGT	p.S1714R	ASXL3_uc002kxq.2_Missense_Mutation_p.S1421R	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1714					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TTCCACCTCAAGTCCCATGGA	0.552			NA											20	68					0	0	0.008871	0	0
ALPK2	115701	broad.mit.edu	37	18	56196383	56196383	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr18:56196383T>A	uc002lhj.3	-	6	5655	c.5441A>T	c.(5440-5442)CAT>CTT	p.H1814L	ALPK2_uc002lhk.1_Missense_Mutation_p.H1145L	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1814	Ig-like 2.			H -> R (in Ref. 1; BX647796).			ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						AGAATCTTCATGAATTTCTGC	0.393			NA											18	98					0	0	0.007413	0	0
ADNP2	22850	broad.mit.edu	37	18	77895908	77895908	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr18:77895908G>T	uc002lnw.2	+	4	3067	c.2612G>T	c.(2611-2613)GGC>GTC	p.G871V		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	871					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GGGAGCACCGGCAAGCGAGTG	0.577			NA											11	56					1.08611e-07	1.34941e-07	0.010729	1	0
SHC2	25759	broad.mit.edu	37	19	436408	436408	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:436408G>A	uc002loq.3	-	6	798	c.798C>T	c.(796-798)TAC>TAT	p.Y266Y	SHC2_uc002lop.3_Silent_p.Y7Y	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	266	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTGGCGACGTAGGCCACGT	0.716			NA											7	54					0	0	0.006214	0	0
KEAP1	9817	broad.mit.edu	37	19	10610139	10610139	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:10610139C>T	uc002moq.1	-	2	727	c.571G>A	c.(571-573)GCT>ACT	p.A191T	KEAP1_uc002mor.1_Missense_Mutation_p.A191T	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	191	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATCTGCTCAGCGAAGTTGGCG	0.607			NA											6	40					0	0	0.001984	0	0
RFX1	5989	broad.mit.edu	37	19	14076266	14076266	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:14076266C>A	uc002mxv.2	-	16	2478	c.2206G>T	c.(2206-2208)GTG>TTG	p.V736L		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	736					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CTCACCTTCACCCGCAGCATC	0.617			NA											45	148					1.11015e-26	1.75062e-26	0.00361	1	0
GTPBP3	84705	broad.mit.edu	37	19	17451852	17451852	+	Splice_Site	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:17451852G>T	uc010eas.2	+	8	1040	c.975_splice	c.e8-1	p.R325_splice	GTPBP3_uc010xpo.1_Splice_Site_p.R347_splice|GTPBP3_uc002ngh.3_Intron|GTPBP3_uc002ngg.3_Splice_Site_p.R357_splice|GTPBP3_uc002ngi.3_Splice_Site	NM_032620	NP_116009	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial) isoform V						tRNA modification	mitochondrion	GTP binding|GTPase activity			skin(1)	1						TGCTCCCGCAGGCTAGAGCAG	0.612			NA											13	47					9.05144e-12	1.26228e-11	0.001855	1	0
ZNF506	440515	broad.mit.edu	37	19	19906467	19906467	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:19906467T>A	uc010eci.2	-	4	377	c.229A>T	c.(229-231)ATG>TTG	p.M77L	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.M45L	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						TGAGAATACATAACTGAAAGA	0.303			NA											9	22					0	0	0.004482	0	0
ZNF98	148198	broad.mit.edu	37	19	22574896	22574896	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:22574896C>T	uc002nqt.2	-	4	1263	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	381	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CCACATTCTTCACACTTGTAG	0.383			NA											5	30					0	0	0.010729	0	0
HAMP	57817	broad.mit.edu	37	19	35775872	35775872	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:35775872C>A	uc002nyw.2	+	3	253	c.182C>A	c.(181-183)ACC>AAC	p.T61N		NM_021175	NP_066998	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide preproprotein	61					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			central_nervous_system(1)	1	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AGGCGAGACACCCACTTCCCC	0.597			NA											18	186					1.10513e-12	1.59544e-12	0.002299	1	0
SBSN	374897	broad.mit.edu	37	19	36019165	36019165	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:36019165C>A	uc002oae.1	-	1	89	c.19G>T	c.(19-21)GTC>TTC	p.V7F	SBSN_uc002oad.1_Missense_Mutation_p.V7F	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	7						extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAGGAGCCGACCAGACGTGCA	0.592			NA											12	22					7.03913e-09	9.13304e-09	0.001368	1	0
KLK7	5650	broad.mit.edu	37	19	51483496	51483496	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:51483496C>A	uc002puo.2	-	4	571	c.469G>T	c.(469-471)GTG>TTG	p.V157L	KLK7_uc002pup.2_Missense_Mutation_p.V157L|KLK7_uc010yco.1_Missense_Mutation_p.V31L|KLK7_uc010eok.2_Missense_Mutation_p.V85L	NM_139277	NP_644806	P49862	KLK7_HUMAN	stratum corneum chymotryptic enzyme	157	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		ggCCACCTACCATCTGGGCTC	0.338			NA											9	14					0.000442599	0.000504071	0.006214	1	0
ZNF610	162963	broad.mit.edu	37	19	52869067	52869067	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:52869067T>A	uc002pyx.3	+	6	842	c.436T>A	c.(436-438)TAC>AAC	p.Y146N	ZNF610_uc002pyy.3_Missense_Mutation_p.Y146N|ZNF610_uc002pyz.3_Missense_Mutation_p.Y103N|ZNF610_uc002pza.2_Missense_Mutation_p.Y146N	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AAGGAAAATTTACAGAAGTAA	0.348			NA											16	124					0	0	0.00499	0	0
RDH13	112724	broad.mit.edu	37	19	55556498	55556498	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:55556498C>A	uc002qio.3	-	7	1125	c.940G>T	c.(940-942)GCC>TCC	p.A314S	RDH13_uc002qip.2_Missense_Mutation_p.A243S|RDH13_uc010esr.1_RNA	NM_001145971	NP_001139443	Q8NBN7	RDH13_HUMAN	retinol dehydrogenase 13 isoform 1	314							binding|oxidoreductase activity			large_intestine(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(297;0.199)	GBM - Glioblastoma multiforme(193;0.0504)	Vitamin A(DB00162)	ACCAGGCGGGCACTTTCAGCC	0.622			NA											10	23					1.33987e-11	1.8559e-11	0.008291	1	0
AGBL5	60509	broad.mit.edu	37	2	27293105	27293105	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:27293105C>A	uc002rie.2	+	15	2852	c.2635C>A	c.(2635-2637)CCA>ACA	p.P879T	AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	879					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAAATCTCCCCCACTGACTGT	0.498			NA											23	73					9.57634e-11	1.3001e-10	0.00333	1	0
BIRC6	57448	broad.mit.edu	37	2	32640261	32640261	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:32640261C>G	uc010ezu.2	+	10	2036	c.1902C>G	c.(1900-1902)AGC>AGG	p.S634R		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	634					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTCTTTATAGCATCAAGGAAT	0.363	Pancreas(94;175 1509 16028 18060 45422)		NA											7	17					0	0	0.004482	0	0
NAT8	9027	broad.mit.edu	37	2	73868535	73868535	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:73868535A>T	uc002sji.1	-	2	388	c.221T>A	c.(220-222)CTG>CAG	p.L74Q		NM_003960	NP_003951	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8	74	Helical; (Potential).|N-acetyltransferase.				gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			ovary(1)	1						AAGGAACCACAGGGCAGGGAA	0.552			NA											30	84					0	0	0.012213	0	0
IL1RL2	8808	broad.mit.edu	37	2	102835488	102835488	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:102835488A>G	uc002tbs.2	+	7	926	c.800A>G	c.(799-801)AAC>AGC	p.N267S	IL1RL2_uc002tbt.2_Missense_Mutation_p.N149S	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	267	Extracellular (Potential).|Ig-like C2-type 3.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						AGAGTCAATAACACTTTGGTG	0.378			NA											15	92					0	0	0.003163	0	0
IL18RAP	8807	broad.mit.edu	37	2	103061723	103061723	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:103061723G>C	uc002tbx.2	+	9	1479	c.995G>C	c.(994-996)CGC>CCC	p.R332P	IL18RAP_uc010fiz.2_Missense_Mutation_p.R190P	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	332	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						CGTGATCTTCGCAGGAAGTTT	0.423			NA											11	42					0	0	0.008291	0	0
MYO7B	4648	broad.mit.edu	37	2	128384580	128384580	+	Silent	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:128384580C>T	uc002top.2	+	31	4221	c.4168C>T	c.(4168-4170)CTG>TTG	p.L1390L	MYO7B_uc002toq.1_Silent_p.L243L|MYO7B_uc002tor.1_Silent_p.L243L	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1390	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGTCACACCACTGGCCGTGCG	0.612			NA											5	12					0	0	0.000602	0	0
NCKAP5	344148	broad.mit.edu	37	2	133486463	133486463	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:133486463C>T	uc002ttp.2	-	18	5880	c.5506G>A	c.(5506-5508)GGA>AGA	p.G1836R	NCKAP5_uc002ttq.2_Missense_Mutation_p.G517R	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1836							protein binding				0						TCAGCATATCCGAATGATGAG	0.537			NA											20	249					0	0	0.008871	0	0
ACVR1	90	broad.mit.edu	37	2	158637031	158637031	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:158637031C>A	uc002tzm.3	-	5	488	c.149G>T	c.(148-150)GGC>GTC	p.G50V	ACVR1_uc002tzn.3_Missense_Mutation_p.G50V|ACVR1_uc010fog.2_Missense_Mutation_p.G50V	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	50	Extracellular (Potential).				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	GCACTGCTGGCCTTCACAGTG	0.507			NA											8	70					2.17888e-05	2.5524e-05	0.006214	1	0
COL5A2	1290	broad.mit.edu	37	2	189912942	189912942	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:189912942C>A	uc002uqk.2	-	45	3469	c.3194G>T	c.(3193-3195)GGA>GTA	p.G1065V	COL5A2_uc010frx.2_Missense_Mutation_p.G641V	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1065					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TACACGTTCTCCAACAGCACC	0.343			NA											8	41					0.00448238	0.00486184	0.004482	1	0
CCDC150	284992	broad.mit.edu	37	2	197584364	197584364	+	Silent	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:197584364A>T	uc002utp.1	+	19	2274	c.2139A>T	c.(2137-2139)TCA>TCT	p.S713S	CCDC150_uc010zgs.1_Silent_p.S360S|CCDC150_uc010zgt.1_Silent_p.S130S|CCDC150_uc002utq.1_Silent_p.S28S|CCDC150_uc002utr.1_Silent_p.S28S	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	713	Potential.										0						GGAGGGATTCAGAGATTGCAG	0.438			NA											5	18					0	0	0.000602	0	0
CDK5R2	8941	broad.mit.edu	37	2	219825610	219825610	+	Silent	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:219825610C>A	uc002vjf.2	+	1	1213	c.1068C>A	c.(1066-1068)GCC>GCA	p.A356A		NM_003936	NP_003927	Q13319	CD5R2_HUMAN	cyclin-dependent kinase 5, regulatory subunit 2	356					regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase 5 holoenzyme complex	cyclin-dependent protein kinase 5 activator activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTGCGCGGCCGGAACCAAGC	0.522			NA											6	9					0.00116845	0.00129476	0.001168	1	0
ALPI	248	broad.mit.edu	37	2	233323439	233323439	+	Silent	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr2:233323439C>T	uc002vst.3	+	10	1358	c.1281C>T	c.(1279-1281)GAC>GAT	p.D427D	ALPI_uc002vsu.3_Silent_p.D338D	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	427					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TGCGACCAGACGTGAATGAGA	0.662			NA											9	53					0	0	0.006214	0	0
SEL1L2	80343	broad.mit.edu	37	20	13847462	13847462	+	Silent	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr20:13847462G>T	uc010gcf.2	-	15	1372	c.1290C>A	c.(1288-1290)GCC>GCA	p.A430A	SEL1L2_uc002woq.3_Silent_p.A291A|SEL1L2_uc010zrl.1_Silent_p.A430A|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	430	Extracellular (Potential).|Sel1-like 8.					integral to membrane	binding			ovary(2)	2						AATATTTGAAGGCAAGTTTAT	0.368			NA											13	86					5.50884e-06	6.56577e-06	0.001368	1	0
CST4	1472	broad.mit.edu	37	20	23667775	23667775	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr20:23667775G>T	uc002wto.1	-	2	348	c.292C>A	c.(292-294)CAG>AAG	p.Q98K		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	98						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					AAGTTGGGCTGGGACTTGGTA	0.582			NA											21	192					7.26314e-15	1.07894e-14	0.007291	1	0
FRG1B	284802	broad.mit.edu	37	20	29624070	29624070	+	Missense_Mutation	SNP	G	G	A	rs79198850		TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr20:29624070G>A	uc010ztl.1	+	1	36	c.4G>A	c.(4-6)GCT>ACT	p.A2T	FRG1B_uc002wvm.1_Intron|FRG1B_uc010ztj.1_Intron|FRG1B_uc010gdr.1_Intron|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GCAGTTTATGGCTGTCAAATT	0.269			NA											3	27					0	0	0.001168	0	0
FRG1B	284802	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr20:29628300G>A	uc010ztl.1	+	3	244	c.212G>A	c.(211-213)AGT>AAT	p.S71N	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.S23N					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GAAGCAAAAAGTAAAACAGCA	0.358			NA											4	91					0	0	0.009096	0	0
PHF20	51230	broad.mit.edu	37	20	34526674	34526674	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr20:34526674G>T	uc002xek.1	+	16	2467	c.2356G>T	c.(2356-2358)GGG>TGG	p.G786W		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	786					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					ACAGCACTCAGGGGAGGGGAG	0.547			NA											15	132					1.52009e-12	2.14909e-12	0.003163	1	0
PTPRT	11122	broad.mit.edu	37	20	40944458	40944458	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr20:40944458C>A	uc002xkg.2	-	12	2228	c.2044G>T	c.(2044-2046)GGT>TGT	p.G682C	PTPRT_uc010ggj.2_Missense_Mutation_p.G682C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	682	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTATTGTCACCCACTGTAAAT	0.517			NA											15	106					2.48551e-13	3.63949e-13	0.00499	1	0
EEF1A2	1917	broad.mit.edu	37	20	62122063	62122063	+	Silent	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr20:62122063C>A	uc002yfd.1	-	5	899	c.798G>T	c.(796-798)CGG>CGT	p.R266R	EEF1A2_uc002yfe.1_Silent_p.R266R|EEF1A2_uc010gkg.1_Silent_p.R266R	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	266						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CGGTCTCCACCCGGCCCACGG	0.662			NA											10	48					1.08611e-07	1.34941e-07	0.010729	1	0
BAGE2	85319	broad.mit.edu	37	21	11049593	11049593	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr21:11049593G>C	uc002yit.1	-	4	516	c.308C>G	c.(307-309)GCG>GGG	p.A103G		NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCGGGCTGTCGCACACTGCAC	0.383			NA											4	177					0	0	0.00308	0	0
PFKL	5211	broad.mit.edu	37	21	45741641	45741641	+	Silent	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr21:45741641G>T	uc002zel.2	+	13	1280	c.1221G>T	c.(1219-1221)GTG>GTT	p.V407V	PFKL_uc002zek.2_Silent_p.V454V|PFKL_uc002zem.2_5'UTR|PFKL_uc002zen.2_5'UTR	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	407					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		TCCTGAATGTGGGGGCCCCGG	0.642			NA											4	46					0.00024832	0.000285987	0.009096	1	0
PFKL	5211	broad.mit.edu	37	21	45741647	45741647	+	Silent	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr21:45741647C>G	uc002zel.2	+	13	1286	c.1227C>G	c.(1225-1227)GCC>GCG	p.A409A	PFKL_uc002zek.2_Silent_p.A456A|PFKL_uc002zem.2_5'UTR|PFKL_uc002zen.2_5'UTR	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	409					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		ATGTGGGGGCCCCGGCGGCTG	0.642			NA											5	47					0	0	0.000602	0	0
PPARG	5468	broad.mit.edu	37	3	12434185	12434185	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr3:12434185A>G	uc003bwx.2	+	4	644	c.553A>G	c.(553-555)AAA>GAA	p.K185E	PPARG_uc003bwr.2_Missense_Mutation_p.K157E|PPARG_uc003bws.2_Missense_Mutation_p.K157E|PPARG_uc003bwu.2_Missense_Mutation_p.K157E|PPARG_uc003bwv.2_Missense_Mutation_p.K157E|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Missense_Mutation_p.K157E|PPARG_uc003bwt.1_Missense_Mutation_p.K157E|PPARG_uc003bww.1_Missense_Mutation_p.K185E	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	185	NR C4-type.|Nuclear receptor.				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	GATCCACAAAAAAAGTAGAAA	0.363			NA	T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						8	55					0	0	0.004482	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307265	39307265	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr3:39307265G>A	uc003cjl.2	-	2	828	c.736C>T	c.(736-738)CCC>TCC	p.P246S		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	246	Helical; Name=6; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		ACGTTGTAGGGTGTCCAGAAG	0.468			NA											13	40					0	0	0.001368	0	0
MITF	4286	broad.mit.edu	37	3	69987131	69987132	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr3:69987131_69987132GG>TT	uc003dnz.2	+	3	629_630	c.513_514GG>TT	c.(511-516)CCGGTG>CCTTTG	p.V172L	MITF_uc011bgb.1_Missense_Mutation_p.V120L|MITF_uc003doa.2_Missense_Mutation_p.V171L|MITF_uc003dob.2_Missense_Mutation_p.V156L|MITF_uc003dod.2_Missense_Mutation_p.V147L|MITF_uc003doe.2_Missense_Mutation_p.V65L|MITF_uc003dof.2_Missense_Mutation_p.V65L	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	172					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		TCATGCCACCGGTGCCGGGGAG	0.505	Melanoma(29;269 969 31479 41502 42961)		NA	A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						11	57					0	0	0.004672	0	0
MORC1	27136	broad.mit.edu	37	3	108829596	108829596	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr3:108829596C>A	uc003dxl.2	-	3	241	c.154G>T	c.(154-156)GTG>TTG	p.V52L	MORC1_uc011bhn.1_Missense_Mutation_p.V52L	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	52					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						ATCTGCTCACCTGAAAAGACA	0.294			NA											3	18					0.00024832	0.000285987	0.009096	1	0
PARP14	54625	broad.mit.edu	37	3	122437576	122437576	+	Silent	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr3:122437576C>A	uc003efq.3	+	14	4637	c.4578C>A	c.(4576-4578)TCC>TCA	p.S1526S	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Silent_p.S1243S|PARP14_uc003efs.1_Silent_p.S1243S	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1526	WWE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		AACAGGAATCCCGGGCAGATT	0.383			NA											45	116					2.13384e-23	3.289e-23	0.00361	1	0
PLSCR5	389158	broad.mit.edu	37	3	146309535	146309535	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr3:146309535C>T	uc003ewb.2	-	5	1591	c.587G>A	c.(586-588)TGT>TAT	p.C196Y	PLSCR5_uc010hvb.2_Missense_Mutation_p.C184Y|PLSCR5_uc010hvc.2_Missense_Mutation_p.C196Y	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	196											0						AAAACAGCCACATGTCACACA	0.348			NA											4	23					0	0	0.001168	0	0
ABCF3	55324	broad.mit.edu	37	3	183906908	183906908	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr3:183906908C>G	uc003fmz.2	+	10	1143	c.1010C>G	c.(1009-1011)GCC>GGC	p.A337G	ABCF3_uc003fna.2_Missense_Mutation_p.A331G|ABCF3_uc003fnb.2_Missense_Mutation_p.A18G	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	337	ABC transporter 1.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATGAGGCTGGCCCTGGCCCGG	0.562			NA											8	20					0	0	0.006214	0	0
CTBP1	1487	broad.mit.edu	37	4	1206787	1206787	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr4:1206787G>A	uc003gcv.1	-	8	1218	c.1053C>T	c.(1051-1053)GTC>GTT	p.V351V	uc003gcs.1_Intron|CTBP1_uc003gct.1_Silent_p.V332V|CTBP1_uc003gcu.1_Silent_p.V340V|CTBP1_uc003gcw.2_Silent_p.V25V	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	351	Interaction with GLIS2 2 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		GGTCCTTGTTGACACAGTTCT	0.652			NA											8	97					0	0	0.006214	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25351193	25351193	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr4:25351193G>C	uc003grl.3	+	7	875	c.839G>C	c.(838-840)GGT>GCT	p.G280A	ZCCHC4_uc003grm.1_RNA|ZCCHC4_uc003grn.3_Missense_Mutation_p.G46A	NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	280							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				CCTCCGTTTGGTGGCTTGGTT	0.373			NA											3	158					0	0	0.004672	0	0
GUF1	60558	broad.mit.edu	37	4	44687997	44687997	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr4:44687997A>G	uc003gww.3	+	7	898	c.691A>G	c.(691-693)AAT>GAT	p.N231D	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	231					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						ACTTGGAACAAATGTTGAGAG	0.313			NA											6	68					0	0	0.004482	0	0
CWH43	80157	broad.mit.edu	37	4	49052739	49052739	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr4:49052739G>A	uc003gyv.2	+	15	2076	c.1894G>A	c.(1894-1896)GAA>AAA	p.E632K	CWH43_uc011bzl.1_Missense_Mutation_p.E605K	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	632					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						CTCCCATGCTGAACTGAGTGA	0.383			NA											7	78					0	0	0.004482	0	0
EPHA5	2044	broad.mit.edu	37	4	66467836	66467836	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr4:66467836C>T	uc003hcy.2	-	3	626	c.433G>A	c.(433-435)GGG>AGG	p.G145R	EPHA5_uc003hcx.2_Missense_Mutation_p.G76R|EPHA5_uc003hcz.2_Missense_Mutation_p.G145R|EPHA5_uc011cah.1_Missense_Mutation_p.G145R|EPHA5_uc011cai.1_Missense_Mutation_p.G145R|EPHA5_uc003hda.2_Missense_Mutation_p.G145R	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	145	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TTACAGGTCCCCAGTCCTCCA	0.423			NA								TSP Lung(17;0.13)			15	52					0	0	0.003163	0	0
MRPS18C	51023	broad.mit.edu	37	4	84377294	84377294	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr4:84377294G>A	uc003hor.3	+	1	177	c.64G>A	c.(64-66)GCT>ACT	p.A22T	HELQ_uc003hom.2_5'Flank|HELQ_uc010ikb.2_5'Flank|HELQ_uc003hol.3_5'Flank|HELQ_uc010ikc.2_5'Flank|HELQ_uc003hon.1_5'Flank|HELQ_uc003hoo.1_5'Flank|HELQ_uc003hop.1_5'Flank|HELQ_uc003hoq.1_5'Flank|MRPS18C_uc011ccu.1_Missense_Mutation_p.A22T	NM_016067	NP_057151	Q9Y3D5	RT18C_HUMAN	mitochondrial ribosomal protein S18C precursor	22					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0		Hepatocellular(203;0.114)				CTTGGTAACGGCTGCTGTCAG	0.512			NA											24	128					0	0	0.003954	0	0
PIK3R1	5295	broad.mit.edu	37	5	67590998	67590998	+	Silent	SNP	T	T	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr5:67590998T>C	uc003jva.2	+	13	2151	c.1591T>C	c.(1591-1593)TTG>CTG	p.L531L	PIK3R1_uc003jvb.2_Silent_p.L531L|PIK3R1_uc003jvc.2_Silent_p.L231L|PIK3R1_uc003jvd.2_Silent_p.L261L|PIK3R1_uc003jve.2_Silent_p.L210L|PIK3R1_uc011crb.1_Silent_p.L201L	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	531					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTATGATAAGTTGAAGTCTCG	0.363			NA	Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			6	43					0	0	0.00308	0	0
TMEM173	340061	broad.mit.edu	37	5	138857009	138857009	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr5:138857009C>A	uc003lep.2	-	7	1102	c.851G>T	c.(850-852)AGG>ATG	p.R284M		NM_198282	NP_938023	Q86WV6	TM173_HUMAN	transmembrane protein 173	284	Cytoplasmic (Potential).				activation of innate immune response|apoptosis|cellular response to exogenous dsRNA|defense response to virus|innate immune response|interferon-beta production|positive regulation of defense response to virus by host|positive regulation of protein binding|positive regulation of protein import into nucleus, translocation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane|perinuclear region of cytoplasm|plasma membrane	protein homodimerization activity|protein kinase binding|transcription factor binding			upper_aerodigestive_tract(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CTGCTCAAGCCTATCCTCCCG	0.572			NA											26	90					4.4004e-07	5.36954e-07	0.00333	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140712464	140712464	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr5:140712464C>T	uc003lji.1	+	1	2213	c.2213C>T	c.(2212-2214)TCG>TTG	p.S738L	PCDHGA1_uc011dan.1_Missense_Mutation_p.S738L	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	738	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCCGGTTCGCACTTTGTG	0.642			NA											24	80					0	0	0.00278	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140784592	140784592	+	Silent	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr5:140784592C>G	uc003lkh.1	+	1	2073	c.2073C>G	c.(2071-2073)CTC>CTG	p.L691L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.L691L	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	691	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTTACCCTCTACCTCGTTG	0.592			NA											32	103					0	0	0.002836	0	0
PDGFRB	5159	broad.mit.edu	37	5	149498364	149498364	+	Silent	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr5:149498364G>T	uc003lro.2	-	21	3319	c.2850C>A	c.(2848-2850)CCC>CCA	p.P950P	PDGFRB_uc010jhd.2_Silent_p.P789P	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	950	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GCTGGGAGAAGGGGGGCCGAA	0.577			NA	T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								20	139					5.35356e-11	7.31653e-11	0.00278	1	0
HUS1B	135458	broad.mit.edu	37	6	656374	656374	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr6:656374G>C	uc003mtg.2	-	1	591	c.571C>G	c.(571-573)CTG>GTG	p.L191V	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	191											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		TCTATACTCAGGGTCATCCTG	0.562			NA											40	164					0	0	0.007835	0	0
SLC17A4	10050	broad.mit.edu	37	6	25771165	25771165	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr6:25771165G>T	uc003nfe.2	+	6	750	c.631G>T	c.(631-633)GGG>TGG	p.G211W	SLC17A4_uc011djx.1_Intron|SLC17A4_uc003nff.1_Intron|SLC17A4_uc003nfg.2_Missense_Mutation_p.G148W|SLC17A4_uc010jqa.2_5'Flank	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	211	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						GTCAATGCTGGGGTCCTTCAT	0.458			NA											33	121					4.00102e-26	6.26113e-26	0.00623	1	0
HLA-C	3107	broad.mit.edu	37	6	31238055	31238055	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr6:31238055C>A	uc003nsy.2	-	4	834	c.827G>T	c.(826-828)GGA>GTA	p.G276V	HLA-C_uc011dnj.1_Missense_Mutation_p.G248V|HLA-C_uc003nsx.2_Missense_Mutation_p.G155V|HLA-C_uc003nsz.2_Missense_Mutation_p.G276V|HLA-C_uc010jsl.2_Missense_Mutation_p.G276V|HLA-C_uc003nta.2_Missense_Mutation_p.G276V|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_Missense_Mutation_p.G155V	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	276	Extracellular (Potential).|Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						CTGCTCTTGTCCAGAAGGCAC	0.607			NA											5	19					0.00116845	0.00129476	0.001168	1	0
LEMD2	221496	broad.mit.edu	37	6	33756865	33756865	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr6:33756865C>G	uc011drm.1	-	1	42	c.29G>C	c.(28-30)CGG>CCG	p.R10P	LEMD2_uc011drl.1_5'Flank|LEMD2_uc003ofe.2_5'UTR	NM_181336	NP_851853	Q8NC56	LEMD2_HUMAN	LEM domain containing 2 isoform 1	10	LEM.					integral to nuclear inner membrane				central_nervous_system(1)	1						CAGCTCCCGCCGCAGTTCCAG	0.632			NA											6	31					0	0	0.00308	0	0
TDRD6	221400	broad.mit.edu	37	6	46656968	46656968	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr6:46656968G>A	uc003oyj.2	+	1	1103	c.1103G>A	c.(1102-1104)CGA>CAA	p.R368Q	TDRD6_uc010jze.2_Missense_Mutation_p.R362Q	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	368	Tudor 2.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GAATATTTTCGAATGCCGGTG	0.547			NA											19	84					0	0	0.008871	0	0
REPS1	85021	broad.mit.edu	37	6	139229864	139229864	+	Silent	SNP	T	T	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr6:139229864T>C	uc003qii.2	-	18	2736	c.2157A>G	c.(2155-2157)GAA>GAG	p.E719E	REPS1_uc003qig.3_Silent_p.E692E|REPS1_uc011edr.1_Silent_p.E718E|REPS1_uc003qij.2_Silent_p.E628E|REPS1_uc003qik.2_Silent_p.E325E	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	719	Interaction with RALBP1 (By similarity).					coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TTTGTGTATGTTCATCAACTT	0.398			NA											12	88					0	0	0.001855	0	0
ACTB	60	broad.mit.edu	37	7	5567400	5567400	+	Missense_Mutation	SNP	G	G	C	rs71531321		TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:5567400G>C	uc003sos.3	-	5	1143	c.1107C>G	c.(1105-1107)ATC>ATG	p.I369M	ACTB_uc003sor.3_Missense_Mutation_p.I247M|ACTB_uc003sot.3_Missense_Mutation_p.I369M|ACTB_uc003soq.3_Missense_Mutation_p.I247M|ACTB_uc010ksy.2_Missense_Mutation_p.I247M	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	369					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGCGGTGGACGATGGAGGGGC	0.537			NA											26	241					0	0	0.009535	0	0
ETV1	2115	broad.mit.edu	37	7	13971233	13971233	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:13971233G>A	uc011jxq.1	-	9	1435	c.696C>T	c.(694-696)CAC>CAT	p.H232H	ETV1_uc011jxn.1_Silent_p.H192H|ETV1_uc011jxo.1_Silent_p.H129H|ETV1_uc011jxp.1_Silent_p.H174H|ETV1_uc003ssw.3_Silent_p.H232H|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.H214H|ETV1_uc011jxs.1_Silent_p.H214H|ETV1_uc010ktv.2_Silent_p.H101H	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	232					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						ACACTGGGTCGTGGTACTCCT	0.522			NA	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								9	37					0	0	0.008291	0	0
WIPF3	644150	broad.mit.edu	37	7	29918676	29918676	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:29918676C>T	uc003taj.1	+	3	275	c.275C>T	c.(274-276)GCG>GTG	p.A92V		NM_001080529	NP_001073998	A6NGB9	WIPF3_HUMAN	WAS/WASL interacting protein family, member 3	92										ovary(1)	1						ACACGAGGCGCGAGCACACCT	0.517			NA											3	10					0	0	0.009096	0	0
ABCA13	154664	broad.mit.edu	37	7	48559687	48559687	+	Silent	SNP	T	T	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:48559687T>C	uc003toq.2	+	53	13873	c.13848T>C	c.(13846-13848)CCT>CCC	p.P4616P	ABCA13_uc010kys.1_Silent_p.P1691P|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Silent_p.P346P	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4616	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTATTTTTCCTCAATTCTGTC	0.368			NA											2	16					0	0	0.004672	0	0
PCLO	27445	broad.mit.edu	37	7	82430833	82430833	+	Splice_Site	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:82430833C>A	uc003uhx.2	-	22	15296	c.15007_splice	c.e22+1	p.A5003_splice		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTTTACTTACCTTCAGTGTC	0.338			NA											15	37					3.27435e-08	4.19526e-08	0.00245	1	0
SAMD9L	219285	broad.mit.edu	37	7	92765094	92765094	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:92765094G>A	uc003umh.1	-	5	1407	c.191C>T	c.(190-192)CCA>CTA	p.P64L	SAMD9L_uc003umj.1_Missense_Mutation_p.P64L|SAMD9L_uc003umi.1_Missense_Mutation_p.P64L|SAMD9L_uc010lfb.1_Missense_Mutation_p.P64L|SAMD9L_uc003umk.1_Missense_Mutation_p.P64L|SAMD9L_uc010lfc.1_Missense_Mutation_p.P64L|SAMD9L_uc010lfd.1_Missense_Mutation_p.P64L|SAMD9L_uc011khx.1_Missense_Mutation_p.P55L	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	64	SAM.									ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CAAAAGTGCTGGACCCCATGG	0.413			NA											14	92					0	0	0.003163	0	0
LRRN3	54674	broad.mit.edu	37	7	110762846	110762846	+	Silent	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:110762846C>A	uc003vft.3	+	4	1064	c.18C>A	c.(16-18)CTC>CTA	p.L6L	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.L6L|LRRN3_uc003vfs.3_Silent_p.L6L	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	6						integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ACATGCCACTCCGAATTCATG	0.418			NA											17	78					5.3912e-06	6.50116e-06	0.006122	1	0
MLL3	58508	broad.mit.edu	37	7	151962266	151962266	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:151962266G>C	uc003wla.2	-	8	1260	c.1041C>G	c.(1039-1041)TGC>TGG	p.C347W		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	347	PHD-type 1.|RING-type.		C -> G (in a colorectal cancer sample; somatic mutation).		intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding	p.C347G(1)		large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCGGGCTGTCGCACACTGCAC	0.378	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								6	213					0	0	0.001168	0	0
HTR5A	3361	broad.mit.edu	37	7	154875951	154875951	+	Silent	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr7:154875951G>A	uc003wlu.1	+	2	892	c.828G>A	c.(826-828)CGG>CGA	p.R276R		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	276	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		ACACGTGGCGGGAGCAGAAGG	0.612			NA											3	47					0	0	0.004672	0	0
USP17L2	377630	broad.mit.edu	37	8	11994973	11994973	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr8:11994973T>G	uc003wvc.1	-	1	1297	c.1297A>C	c.(1297-1299)ACC>CCC	p.T433P	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	433					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						TGGTCTAAGGTGCTTTCCTGA	0.542			NA											9	32					0	0	0.004482	0	0
CLVS1	157807	broad.mit.edu	37	8	62289263	62289263	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr8:62289263C>A	uc003xuh.2	+	3	879	c.555C>A	c.(553-555)GAC>GAA	p.D185E	CLVS1_uc003xug.2_3'UTR|CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Missense_Mutation_p.D185E	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	185	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						TAATTATAGACTGGAGTAATT	0.423			NA											19	58					0.000958276	0.00107938	0.007413	1	0
ZFHX4	79776	broad.mit.edu	37	8	77616827	77616827	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr8:77616827C>A	uc003yav.2	+	2	891	c.504C>A	c.(502-504)GAC>GAA	p.D168E	ZFHX4_uc003yat.1_Missense_Mutation_p.D168E|ZFHX4_uc003yau.1_Missense_Mutation_p.D168E|ZFHX4_uc003yaw.1_Missense_Mutation_p.D168E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	168						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGTTCCTGGACTCCCTGGCAT	0.473			NA								HNSCC(33;0.089)			7	28					0.00198382	0.00218647	0.001984	1	0
SLC7A13	157724	broad.mit.edu	37	8	87242189	87242189	+	Silent	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr8:87242189C>A	uc003ydq.1	-	1	416	c.318G>T	c.(316-318)GGG>GGT	p.G106G	SLC7A13_uc003ydr.1_Silent_p.G106G	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	106	Helical; Name=3; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						CAGCAACTACCCCTGACCCCA	0.493			NA											4	29					0.00116845	0.00129476	0.001168	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88886072	88886072	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr8:88886072C>A	uc003ydz.2	-	1	225	c.128G>T	c.(127-129)TGC>TTC	p.C43F		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	43										ovary(1)	1						AGCTATACGGCAATAGTTGGC	0.507			NA											14	78					6.81908e-15	1.02037e-14	0.00245	1	0
NCALD	83988	broad.mit.edu	37	8	102731524	102731524	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr8:102731524C>T	uc003yke.2	-	2	703	c.334G>A	c.(334-336)GGA>AGA	p.G112R	NCALD_uc003ykf.2_Missense_Mutation_p.G112R|NCALD_uc003ykg.2_Missense_Mutation_p.G112R|NCALD_uc003ykh.2_Missense_Mutation_p.G112R|NCALD_uc003yki.2_Missense_Mutation_p.G112R|NCALD_uc003ykj.2_Missense_Mutation_p.G112R|NCALD_uc003ykk.2_Missense_Mutation_p.G112R|NCALD_uc003ykl.2_Missense_Mutation_p.G112R	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	112	EF-hand 3.|2 (Potential).				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			TAGCCATTTCCGTCCAGGTCG	0.463			NA											15	133					0	0	0.004007	0	0
SMARCA2	6595	broad.mit.edu	37	9	2039691	2039691	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:2039691G>T	uc003zhc.2	+	4	680	c.581G>T	c.(580-582)CGA>CTA	p.R194L	SMARCA2_uc003zhd.2_Missense_Mutation_p.R194L|SMARCA2_uc010mha.2_Missense_Mutation_p.R185L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	194					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATGCTGGCCCGAGGCCAGCCC	0.478			NA											5	29					0.000602214	0.000682066	0.000602	1	0
MPDZ	8777	broad.mit.edu	37	9	13216825	13216825	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:13216825C>A	uc010mia.1	-	9	1295	c.1238G>T	c.(1237-1239)AGC>ATC	p.S413I	MPDZ_uc010mhy.2_Missense_Mutation_p.S413I|MPDZ_uc010mhz.2_Missense_Mutation_p.S413I|MPDZ_uc011lmn.1_Missense_Mutation_p.S413I|MPDZ_uc003zlb.3_Missense_Mutation_p.S413I	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	413	PDZ 3.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		AACGGCACTGCTTTTTGTAAT	0.318			NA											7	26					3.09899e-07	3.80414e-07	0.004482	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18680333	18680333	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:18680333C>A	uc003zne.3	+	11	1287	c.1160C>A	c.(1159-1161)GCG>GAG	p.A387E	ADAMTSL1_uc003znb.2_Missense_Mutation_p.A370E|ADAMTSL1_uc003znc.3_Missense_Mutation_p.A387E	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	387	TSP type-1 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CCATGGACCGCGTGCTCCTCC	0.602			NA											9	25					1.12685e-05	1.33529e-05	0.004482	1	0
SLC28A3	64078	broad.mit.edu	37	9	86905118	86905118	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:86905118C>G	uc010mpz.2	-	11	1225	c.1100G>C	c.(1099-1101)GGG>GCG	p.G367A	SLC28A3_uc011lsy.1_Missense_Mutation_p.G298A|SLC28A3_uc004anu.1_Missense_Mutation_p.G367A	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	367	Helical; (Potential).		G -> R (reduced transport of inosine and thymidine).		nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						GGTAGAGAACCCGGCGGTCAT	0.458	Ovarian(106;425 1539 34835 42413 43572)		NA											12	63					0	0	0.003163	0	0
C9orf79	286234	broad.mit.edu	37	9	90500907	90500907	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:90500907A>T	uc004app.3	+	4	1540	c.1505A>T	c.(1504-1506)CAG>CTG	p.Q502L	C9orf79_uc004apo.1_Missense_Mutation_p.Q314L	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	502						integral to membrane				ovary(3)	3						cacatggcccagccccaacat	0.204			NA											20	46					0	0	0.007413	0	0
NOL8	55035	broad.mit.edu	37	9	95077881	95077881	+	Silent	SNP	T	T	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:95077881T>C	uc004arv.2	-	7	1363	c.1026A>G	c.(1024-1026)AAA>AAG	p.K342K	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Silent_p.K274K	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	342					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						GAACGCCTGATTTGAAATCAT	0.353			NA											4	18					0	0	0.000602	0	0
FAM120A	23196	broad.mit.edu	37	9	96233568	96233568	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:96233568G>A	uc004atw.2	+	2	645	c.620G>A	c.(619-621)CGG>CAG	p.R207Q	FAM120A_uc004atv.2_Missense_Mutation_p.R207Q|FAM120A_uc004atx.2_5'UTR|FAM120A_uc004aty.2_5'UTR	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	207						cytoplasm|plasma membrane	RNA binding				0						AAACTGAGCCGGAACGGGAAA	0.458			NA											11	75					0	0	0.010729	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377261	125377261	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:125377261T>A	uc011lyy.1	+	1	245	c.245T>A	c.(244-246)CTG>CAG	p.L82Q		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCCAAGATGCTGCAGATTATT	0.473			NA											41	180					0	0	0.006999	0	0
SLC27A4	10999	broad.mit.edu	37	9	131118034	131118034	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr9:131118034G>T	uc004but.2	+	12	2017	c.1733G>T	c.(1732-1734)CGC>CTC	p.R578L	SLC27A4_uc004buu.2_Missense_Mutation_p.R172L	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid	578					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding				0						CTGTATGCGCGCCCCATCTTC	0.637	Pancreas(107;1554 2241 10946 12953)		NA											26	82					9.65021e-13	1.40304e-12	0.010818	1	0
SHOX	6473	broad.mit.edu	37	X	591804	591804	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chrX:591804G>C	uc004cph.1	+	2	863	c.172G>C	c.(172-174)GAC>CAC	p.D58H	SHOX_uc004cpi.2_Missense_Mutation_p.D58H	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	58					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CAGCCTCCAGGACATCACGGA	0.602	Ovarian(95;18 1419 12424 14056 28266)		NA											20	83					0	0	0.012319	0	0
ASMT	438	broad.mit.edu	37	X	1746629	1746629	+	Silent	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chrX:1746629C>A	uc004cqd.2	+	5	553	c.408C>A	c.(406-408)GGC>GGA	p.G136G	ASMT_uc010ncy.2_Silent_p.G136G|ASMT_uc004cqe.2_Silent_p.G136G	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	136					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGACGTTTGGCGTTCCCGCTG	0.338			NA											22	169					4.7796e-09	6.24088e-09	0.004656	1	0
FAM47B	170062	broad.mit.edu	37	X	34961245	34961245	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chrX:34961245G>T	uc004ddi.1	+	1	315	c.297G>T	c.(295-297)AAG>AAT	p.K99N		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	99										ovary(3)|breast(1)	4						AGCTGCTCAAGAAAGCGGCCC	0.527			NA											13	29					0.00244969	0.00268549	0.00245	1	0
UBA1	7317	broad.mit.edu	37	X	47060987	47060987	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chrX:47060987G>T	uc004dhj.3	+	8	940	c.789G>T	c.(787-789)CAG>CAT	p.Q263H	UBA1_uc004dhk.3_Missense_Mutation_p.Q263H	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	263	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						ACGGAAATCAGCCCATGGAGA	0.552			NA											14	9					1.37285e-15	2.06937e-15	0.004007	1	0
HEPH	9843	broad.mit.edu	37	X	65480099	65480099	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chrX:65480099G>C	uc011moz.1	+	19	3263	c.3203G>C	c.(3202-3204)CGA>CCA	p.R1068P	HEPH_uc004dwn.2_Missense_Mutation_p.R1068P|HEPH_uc004dwo.2_Missense_Mutation_p.R798P|HEPH_uc010nkr.2_Missense_Mutation_p.R876P|HEPH_uc011mpa.1_Missense_Mutation_p.R1068P	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1065	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GTTTTTTCTCGAACAGGTAAG	0.473			NA											16	11					0	0	0.004007	0	0
AWAT1	158833	broad.mit.edu	37	X	69455988	69455988	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chrX:69455988C>A	uc004dxy.2	+	3	295	c.254C>A	c.(253-255)ACG>AAG	p.T85K		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	85					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity	p.T165M(1)		ovary(3)	3						TTCCCCATTACGGTAAGTATC	0.483			NA											17	26					1.96292e-10	2.63006e-10	0.010504	1	0
DPF2	5977	broad.mit.edu	37	11	65119159	65119173	+	In_Frame_Del	DEL	TGGAGCTGCCACCTG	TGGAGCTGCCACCTG	-			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	TGGAGCTGCCACCTG	TGGAGCTGCCACCTG	-	-	TGGAGCTGCCACCTG	TGGAGCTGCCACCTG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr11:65119159_65119173delTGGAGCTGCCACCTG	uc001odm.2	+	11	1117_1131	c.1105_1119delTGGAGCTGCCACCTG	c.(1105-1119)TGGAGCTGCCACCTGdel	p.WSCHL369del	DPF2_uc001odn.2_In_Frame_Del_p.WSCHL383del|DPF2_uc010roe.1_In_Frame_Del_p.WSCHL185del	NM_006268	NP_006259	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	369_373	PHD-type 2.				apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						TGCAGGAAGTTGGAGCTGCCACCTGTGTCTGGACC	0.521			NA											8	123	---	---	---	---	NA	NA	NA	NA	NA
ADAM6	8755	broad.mit.edu	37	14	106774086	106774087	+	Splice_Site	INS	-	-	AGTAATACACGGCA			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr14:106774086_106774087insAGTAATACACGGCA	uc010tyt.1	-	430		c.15674_splice	c.e430+1							Parts of antibodies, mostly variable regions.												0						GCCTCTTGCACGTGTCCTCAGC	0.55			NA											3	6	---	---	---	---	NA	NA	NA	NA	NA
RASAL3	64926	broad.mit.edu	37	19	15572382	15572382	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:15572382delG	uc002nbe.2	-	3	451	c.365delC	c.(364-366)CCAfs	p.P122fs		NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	122	Pro-rich.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						AGGGATCTGTGGGGTAGGGGG	0.567			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
TMC4	147798	broad.mit.edu	37	19	54675747	54675749	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	TCC	TCC	-	-	TCC	TCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr19:54675747_54675749delTCC	uc010erf.2	-	2	333_335	c.201_203delGGA	c.(199-204)GAGGAT>GAT	p.E67del	TMC4_uc002qdo.2_In_Frame_Del_p.E61del	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	67	Poly-Glu.|Extracellular (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCTTCCTCCATCCTCCTCCTCCT	0.645			NA											7	104	---	---	---	---	NA	NA	NA	NA	NA
TATDN1	83940	broad.mit.edu	37	8	125500846	125500847	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chr8:125500846_125500847insA	uc003yrd.2	-	12	924_925	c.882_883insT	c.(880-885)TTTCCTfs	p.F294fs	RNF139_uc003yrc.2_3'UTR|TATDN1_uc003yre.2_RNA|TATDN1_uc010mdm.2_Frame_Shift_Ins_p.F247fs|TATDN1_uc003yrf.2_Frame_Shift_Ins_p.F330fs	NM_032026	NP_114415	Q6P1N9	TATD1_HUMAN	TatD DNase domain containing 1 isoform a	294_295						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TATATTCCAGGAAAAAATACTT	0.292			NA											7	73	---	---	---	---	NA	NA	NA	NA	NA
RBM10	8241	broad.mit.edu	37	X	47041360	47041364	+	Frame_Shift_Del	DEL	CGTCT	CGTCT	-			TCGA-55-7815-01A-11D-2167-08	TCGA-55-7815-10A-01D-2167-08	CGTCT	CGTCT	-	-	CGTCT	CGTCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	4e4d9dd0-a990-4ec5-841b-7d443b86b059	29aa803b-8c42-444f-8c78-6349908d88e9	g.chrX:47041360_47041364delCGTCT	uc004dhf.2	+	16	2083_2087	c.1704_1708delCGTCT	c.(1702-1710)GACGTCTCTfs	p.D568fs	RBM10_uc004dhg.2_Frame_Shift_Del_p.D490fs|RBM10_uc004dhh.2_Frame_Shift_Del_p.D567fs|RBM10_uc010nhq.2_Frame_Shift_Del_p.D491fs|RBM10_uc004dhi.2_Frame_Shift_Del_p.D633fs	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	568_570	Tyr-rich.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CTGTTCCCGACGTCTCTACCTACCA	0.58	Melanoma(171;120 2705 19495 39241)		NA											15	21	---	---	---	---	NA	NA	NA	NA	NA