Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPX7	2882	broad.mit.edu	37	1	53072531	53072531	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:53072531G>A	uc001cue.2	+	2	353	c.314G>A	c.(313-315)CGC>CAC	p.R105H		NM_015696	NP_056511	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7 precursor	105					response to oxidative stress	extracellular region	glutathione peroxidase activity				0					Glutathione(DB00143)	AGCTTTGCCCGCCGCACCTAC	0.572			NA											7	102					0	0	0.001984	0	0
HSD3B1	3283	broad.mit.edu	37	1	120056843	120056843	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:120056843C>T	uc001ehv.1	+	4	842	c.697C>T	c.(697-699)CAC>TAC	p.H233Y	HSD3B1_uc001ehw.2_Missense_Mutation_p.H235Y	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	233					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	GGCCTGGGCCCACATTCTGGC	0.517			NA											32	53					0	0	0.003271	0	0
CRABP2	1382	broad.mit.edu	37	1	156670345	156670345	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:156670345C>T	uc001fpr.2	-	3	492	c.355G>A	c.(355-357)GAA>AAA	p.E119K		NM_001878	NP_001869	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	119					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			upper_aerodigestive_tract(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	AGGATCAGTTCCCCATCGTTG	0.537			NA											21	108					0	0	0.00333	0	0
DUSP27	92235	broad.mit.edu	37	1	167095768	167095768	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:167095768G>A	uc001geb.1	+	5	1400	c.1400G>A	c.(1399-1401)CGC>CAC	p.R467H		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	467					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						AGGAGGCGCCGCGCAGACTCG	0.652			NA											4	26					0	0	0.000248	0	0
ADCY10	55811	broad.mit.edu	37	1	167798655	167798655	+	Missense_Mutation	SNP	C	C	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:167798655C>G	uc001ger.2	-	26	3898	c.3600G>C	c.(3598-3600)AAG>AAC	p.K1200N	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.K1108N|ADCY10_uc010plj.1_Missense_Mutation_p.K1047N	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1200					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GTGCCAGCCTCTTCTTCCTAT	0.428			NA											13	71					0	0	0.00245	0	0
F5	2153	broad.mit.edu	37	1	169510388	169510388	+	Missense_Mutation	SNP	G	G	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:169510388G>T	uc001ggg.1	-	13	4085	c.3940C>A	c.(3940-3942)CCA>ACA	p.P1314T		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1314	B.|2-15.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCGAGGGCTGGGGAAAGGTTT	0.493			NA											125	632					2.51135e-46	6.49997e-46	0.00361	1	0
NAV1	89796	broad.mit.edu	37	1	201751334	201751334	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:201751334G>A	uc001gwu.2	+	6	2041	c.1694G>A	c.(1693-1695)GGT>GAT	p.G565D	NAV1_uc001gwv.1_Missense_Mutation_p.G73D|NAV1_uc001gww.1_Missense_Mutation_p.G174D|NAV1_uc001gwx.2_Missense_Mutation_p.G174D|NAV1_uc001gwy.1_5'UTR	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	565					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						ACAGACAAGGGTAAGCTTGCA	0.527			NA											28	159					0	0	0.001786	0	0
REN	5972	broad.mit.edu	37	1	204128652	204128652	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:204128652G>A	uc001haq.2	-	5	608	c.564C>T	c.(562-564)GCC>GCT	p.A188A		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	188					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CATCAAACTCGGCCAGCATGA	0.557			NA											10	63					0	0	0.000443	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204419113	204419113	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr1:204419113G>A	uc001haw.2	-	14	2578	c.2099C>T	c.(2098-2100)CCT>CTT	p.P700L	PIK3C2B_uc010pqv.1_Missense_Mutation_p.P700L	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	700					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TGTCTCCCGAGGCAGCCGGTT	0.617			NA											7	6					0	0	0.001984	0	0
UPF2	26019	broad.mit.edu	37	10	11985140	11985140	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr10:11985140C>T	uc001ila.2	-	16	3676	c.3202G>A	c.(3202-3204)GGA>AGA	p.G1068R	UPF2_uc001ilb.2_Missense_Mutation_p.G1068R|UPF2_uc001ilc.2_Missense_Mutation_p.G1068R	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	1068	Glu-rich.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TCTTCTTCTCCCTCATCATCA	0.328			NA											17	113					0	0	0.006122	0	0
AGAP5	729092	broad.mit.edu	37	10	75457292	75457292	+	Missense_Mutation	SNP	T	T	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr10:75457292T>A	uc009xri.2	-	1	263	c.222A>T	c.(220-222)GAA>GAT	p.E74D	AGAP5_uc001juu.3_Missense_Mutation_p.E35D	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	74					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CCTCCTTACCTTCAGGCATCT	0.582			NA											7	134					0	0	0.00245	0	0
MKI67	4288	broad.mit.edu	37	10	129905598	129905598	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr10:129905598G>A	uc001lke.2	-	13	4701	c.4506C>T	c.(4504-4506)GAC>GAT	p.D1502D	MKI67_uc001lkf.2_Silent_p.D1142D|MKI67_uc009yav.1_Silent_p.D1077D|MKI67_uc009yaw.1_Silent_p.D652D	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1502	5.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTGTTGGTGTGTCCACTGGGT	0.498			NA											105	268					0	0	0.00361	0	0
GPR123	84435	broad.mit.edu	37	10	134942303	134942303	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr10:134942303G>A	uc001llx.3	+	7	1407	c.971G>A	c.(970-972)CGC>CAC	p.R324H	GPR123_uc001llw.2_Missense_Mutation_p.R1043H	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	324	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TGCCCGCCCCGCAAGGACGCC	0.726			NA											7	27					0	0	0.001984	0	0
OR4C16	219428	broad.mit.edu	37	11	55340039	55340039	+	Missense_Mutation	SNP	G	G	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr11:55340039G>T	uc010rih.1	+	1	436	c.436G>T	c.(436-438)GCC>TCC	p.A146S		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GATGGCTGTGGCCTGGGTGGG	0.498			NA											66	200					6.2918e-36	1.60953e-35	0.00361	1	0
GANAB	23193	broad.mit.edu	37	11	62397858	62397858	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr11:62397858G>A	uc001nub.2	-	12	1539	c.1506C>T	c.(1504-1506)TGC>TGT	p.C502C	GANAB_uc001nua.2_Silent_p.C524C|GANAB_uc001nuc.2_Silent_p.C405C|GANAB_uc010rma.1_Silent_p.C410C|GANAB_uc010rmb.1_Silent_p.C388C	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	502					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						TACCTGGCCAGCACCAGCCCT	0.572	Melanoma(23;1005 1074 15747 18937)		NA											3	43					0	0	0.004672	0	0
BCL9L	283149	broad.mit.edu	37	11	118770825	118770825	+	Silent	SNP	T	T	C			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr11:118770825T>C	uc001pug.2	-	7	4172	c.3207A>G	c.(3205-3207)CTA>CTG	p.L1069L	BCL9L_uc009zal.2_Silent_p.L1064L	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1069	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		AAGTGAATGGTAGGCTGGGGT	0.642			NA											25	76					0	0	0.001061	0	0
FLT1	2321	broad.mit.edu	37	13	28964125	28964125	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr13:28964125G>A	uc001usb.3	-	13	2062	c.1777C>T	c.(1777-1779)CGG>TGG	p.R593W	FLT1_uc010aar.1_Missense_Mutation_p.R593W|FLT1_uc001usc.3_Missense_Mutation_p.R593W|FLT1_uc010aas.1_RNA|FLT1_uc010aat.1_Missense_Mutation_p.R76W	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	593	Ig-like C2-type 6.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTAACTGTCCGCAGTAAAATC	0.393			NA											5	116					0	0	0.000602	0	0
MYH6	4624	broad.mit.edu	37	14	23870001	23870001	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr14:23870001G>A	uc001wjv.2	-	13	1394	c.1327C>T	c.(1327-1329)CGC>TGC	p.R443C	MYH6_uc010akp.1_Missense_Mutation_p.R443C	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	443	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCGTTGATGCGCGTCACCATC	0.577			NA											14	101					0	0	0.004007	0	0
AKAP6	9472	broad.mit.edu	37	14	33292074	33292074	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr14:33292074G>A	uc001wrq.2	+	13	5225	c.5055G>A	c.(5053-5055)GCG>GCA	p.A1685A		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1685	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAGACTCAGCGGCATCTCTAA	0.433	Melanoma(49;821 1200 7288 13647 42351)		NA											27	92					0	0	0.001786	0	0
SOCS4	122809	broad.mit.edu	37	14	55510343	55510343	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr14:55510343C>T	uc001xbo.2	+	3	1149	c.584C>T	c.(583-585)CCC>CTC	p.P195L	SOCS4_uc001xbp.2_Missense_Mutation_p.P195L	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	195					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2						AATGTTCAGCCCTGTGTCATA	0.398			NA											24	96					0	0	0.00333	0	0
PSMA3	5684	broad.mit.edu	37	14	58727695	58727695	+	Missense_Mutation	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr14:58727695A>G	uc001xdj.1	+	6	480	c.434A>G	c.(433-435)GAC>GGC	p.D145G	C14orf37_uc010tro.1_Intron|PSMA3_uc001xdk.1_Missense_Mutation_p.D138G	NM_002788	NP_002779	P25788	PSA3_HUMAN	proteasome alpha 3 subunit isoform 1	145					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity				0						AGTGTGAATGACGGTGCGCAA	0.313			NA											3	99					0	0	0.004672	0	0
LTBP2	4053	broad.mit.edu	37	14	75017917	75017917	+	Silent	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr14:75017917C>T	uc001xqa.2	-	7	1923	c.1536G>A	c.(1534-1536)CCG>CCA	p.P512P		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	512					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GCAGCCAGGGCGGGGGTCTGG	0.701			NA											9	22					0	0	0.004482	0	0
SNRPN	6638	broad.mit.edu	37	15	25221477	25221477	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr15:25221477C>T	uc001ywp.1	+	9	1071	c.181C>T	c.(181-183)CGT>TGT	p.R61C	SNRPN_uc001ywq.1_Missense_Mutation_p.R61C|SNRPN_uc001ywr.1_Missense_Mutation_p.R61C|SNRPN_uc001yws.1_Missense_Mutation_p.R61C|SNRPN_uc001ywt.1_Missense_Mutation_p.R61C|SNRPN_uc001ywv.1_Missense_Mutation_p.R64C|SNRPN_uc001yww.1_Missense_Mutation_p.R61C|SNRPN_uc001ywx.1_Missense_Mutation_p.R61C|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_3'UTR	NM_022807	NP_073718	P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	61					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		GCAACCAGAGCGTGAAGAAAA	0.428			NA							Prader-Willsyndrome				22	91					0	0	0.003954	0	0
CAPN3	825	broad.mit.edu	37	15	42695961	42695961	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr15:42695961G>A	uc001zpn.1	+	14	2074	c.1768G>A	c.(1768-1770)GTG>ATG	p.V590M	CAPN3_uc001zpk.1_Missense_Mutation_p.V363M|CAPN3_uc001zpl.1_Missense_Mutation_p.V503M|CAPN3_uc010udf.1_Missense_Mutation_p.V503M|CAPN3_uc010udg.1_Missense_Mutation_p.V455M|CAPN3_uc001zpo.1_Missense_Mutation_p.V590M|CAPN3_uc001zpp.1_Missense_Mutation_p.V542M|CAPN3_uc001zpq.1_Missense_Mutation_p.V78M|CAPN3_uc010bcv.1_5'Flank|CAPN3_uc001zpr.1_5'Flank|CAPN3_uc001zps.1_5'Flank|CAPN3_uc001zpt.1_5'Flank	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	590	Linker.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		TACCATCTCCGTGGATCGGCC	0.557			NA											8	155					0	0	0.00308	0	0
STRC	161497	broad.mit.edu	37	15	43893702	43893702	+	Silent	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr15:43893702A>G	uc001zsf.2	-	24	4671	c.4593T>C	c.(4591-4593)CTT>CTC	p.L1531L	STRC_uc010bdl.2_Silent_p.L758L|STRC_uc001zse.2_Silent_p.L49L	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1531					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		AGAGCCTACCAAGCTGCAGGA	0.468			NA											11	82					0	0	0.001855	0	0
STRC	161497	broad.mit.edu	37	15	43893725	43893725	+	Missense_Mutation	SNP	G	G	C	rs147990592		TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr15:43893725G>C	uc001zsf.2	-	24	4648	c.4570C>G	c.(4570-4572)CGT>GGT	p.R1524G	STRC_uc010bdl.2_Missense_Mutation_p.R751G|STRC_uc001zse.2_Missense_Mutation_p.R42G	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1524					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TGCTCAGGACGAAATCCCCGG	0.398			NA											5	73					0	0	0.001984	0	0
DUOX1	53905	broad.mit.edu	37	15	45424180	45424180	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr15:45424180G>A	uc001zus.1	+	3	362	c.16G>A	c.(16-18)GCT>ACT	p.A6T	DUOXA1_uc001zup.2_5'Flank|DUOXA1_uc010bec.2_5'Flank|DUOXA1_uc001zur.1_5'Flank|DUOXA1_uc010bed.1_5'Flank|DUOX1_uc001zut.1_Missense_Mutation_p.A6T|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	6					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTTCTGCCTGGCTCTAGCATG	0.498			NA											10	254					0	0	0.000673	0	0
CA12	771	broad.mit.edu	37	15	63618490	63618490	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr15:63618490G>A	uc002amc.2	-	11	1215	c.1059C>T	c.(1057-1059)CAC>CAT	p.H353H	CA12_uc002amd.2_Silent_p.H342H|CA12_uc002ame.2_Silent_p.H282H	NM_001218	NP_001209	O43570	CAH12_HUMAN	carbonic anhydrase XII isoform 1 precursor	353	Cytoplasmic (Potential).				one-carbon metabolic process	integral to membrane	carbonate dehydratase activity|zinc ion binding			ovary(1)	1					Acetazolamide(DB00819)	GACCTCAAGCGTGGGCCTCAG	0.512			NA											24	94					0	0	0.001061	0	0
LOC595101	595101	broad.mit.edu	37	16	30292628	30292628	+	Splice_Site	SNP	A	A	C			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr16:30292628A>C	uc002dxp.1	-	15		c.2564_splice	c.e15+1			NR_002453				Homo sapiens cDNA FLJ39663 fis, clone SMINT2007187.												0						AGTAATATTCACAGAAGATTT	0.323			NA											4	26					0	0	0.000248	0	0
PITPNM3	83394	broad.mit.edu	37	17	6364731	6364731	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr17:6364731G>A	uc002gdd.3	-	18	2603	c.2452C>T	c.(2452-2454)CGG>TGG	p.R818W	PITPNM3_uc010cln.2_Missense_Mutation_p.R782W|PITPNM3_uc010clm.2_Missense_Mutation_p.R301W|PITPNM3_uc002gdc.3_Missense_Mutation_p.R409W	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	818					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GCCTTCTGCCGCAGCGGGTCA	0.637			NA											25	53					0	0	0.005443	0	0
MYH8	4626	broad.mit.edu	37	17	10322033	10322033	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr17:10322033C>T	uc002gmm.2	-	5	535	c.440G>A	c.(439-441)GGC>GAC	p.G147D	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	147	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GCGCTTTTTGCCTCTGTAGGC	0.542			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				4	141					0	0	0.000248	0	0
ZNF286A	57335	broad.mit.edu	37	17	15620341	15620341	+	Missense_Mutation	SNP	G	G	C			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr17:15620341G>C	uc010cot.2	+	6	1699	c.1303G>C	c.(1303-1305)GAG>CAG	p.E435Q	ZNF286A_uc002goz.3_Missense_Mutation_p.E323Q|ZNF286A_uc010vwa.1_Missense_Mutation_p.E435Q|ZNF286A_uc002gpa.2_Missense_Mutation_p.E435Q	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		TCACACTGGAGAGAAACCCTA	0.388			NA											13	33					0	0	0.00499	0	0
CACNA1G	8913	broad.mit.edu	37	17	48696099	48696099	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr17:48696099G>A	uc002irk.1	+	33	5883	c.5511G>A	c.(5509-5511)ACG>ACA	p.T1837T	CACNA1G_uc002irj.1_Silent_p.T1803T|CACNA1G_uc002irl.1_Silent_p.T1814T|CACNA1G_uc002irm.1_Silent_p.T1803T|CACNA1G_uc002irn.1_Silent_p.T1796T|CACNA1G_uc002iro.1_Silent_p.T1803T|CACNA1G_uc002irp.1_Silent_p.T1837T|CACNA1G_uc002irq.1_Silent_p.T1814T|CACNA1G_uc002irr.1_Silent_p.T1837T|CACNA1G_uc002irs.1_Silent_p.T1826T|CACNA1G_uc002irt.1_Silent_p.T1819T|CACNA1G_uc002irv.1_Silent_p.T1826T|CACNA1G_uc002irw.1_Silent_p.T1814T|CACNA1G_uc002iru.1_Silent_p.T1803T|CACNA1G_uc002irx.1_Silent_p.T1750T|CACNA1G_uc002iry.1_Silent_p.T1739T|CACNA1G_uc002irz.1_Silent_p.T1743T|CACNA1G_uc002isa.1_Silent_p.T1716T|CACNA1G_uc002isb.1_Silent_p.T1757T|CACNA1G_uc002isc.1_Silent_p.T1739T|CACNA1G_uc002isd.1_Silent_p.T1725T|CACNA1G_uc002ise.1_Silent_p.T1705T|CACNA1G_uc002isf.1_Silent_p.T1732T|CACNA1G_uc002isg.1_Silent_p.T1698T|CACNA1G_uc002ish.1_Silent_p.T1705T|CACNA1G_uc002isi.1_Silent_p.T1693T	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1837	IV.|Helical; Name=S6 of repeat IV; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TCGTGCTGACGGCCCAGTTCG	0.592			NA											8	46					0	0	0.004482	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625694	74625694	+	Silent	SNP	T	T	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr17:74625694T>A	uc002jsh.2	-	2	405	c.231A>T	c.(229-231)GCA>GCT	p.A77A	ST6GALNAC1_uc002jsi.2_5'UTR|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	77	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						GCACTGGCTCTGCATAGATGG	0.572			NA											7	217					0	0	0.001984	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996170	19996170	+	Silent	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr18:19996170C>T	uc002ktv.1	-	1	1709	c.1605G>A	c.(1603-1605)CCG>CCA	p.P535P		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	535						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TCTGATGGTCCGGAGGATTCC	0.552			NA											4	115					0	0	0.000248	0	0
LONP1	9361	broad.mit.edu	37	19	5699098	5699098	+	Missense_Mutation	SNP	C	C	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr19:5699098C>A	uc002mcx.2	-	10	1658	c.1625G>T	c.(1624-1626)CGA>CTA	p.R542L	LONP1_uc002mcy.2_Missense_Mutation_p.R478L|LONP1_uc010duh.2_Missense_Mutation_p.R283L|LONP1_uc010dui.2_Missense_Mutation_p.R526L|LONP1_uc002mcz.2_Missense_Mutation_p.R346L	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	542					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GAAGTACTCTCGGTTCAGGGC	0.652			NA											12	39					1.5842e-08	3.916e-08	0.001855	1	0
ZNF506	440515	broad.mit.edu	37	19	19905881	19905881	+	Missense_Mutation	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr19:19905881A>G	uc010eci.2	-	4	963	c.815T>C	c.(814-816)CTT>CCT	p.L272P	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.L240P	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	272	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						ATGTGAAAAAAGGGTTGCAGG	0.373			NA											3	56					0	0	0.000248	0	0
ZNF208	7757	broad.mit.edu	37	19	22154452	22154452	+	Silent	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr19:22154452A>G	uc002nqp.2	-	6	3149	c.3000T>C	c.(2998-3000)CTT>CTC	p.L1000L	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TATGTTTAGTAAGGATTGAGA	0.373			NA											3	107					0	0	0.004672	0	0
KLK3	354	broad.mit.edu	37	19	51361824	51361824	+	Silent	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr19:51361824C>T	uc002pts.1	+	4	644	c.603C>T	c.(601-603)CGC>CGT	p.R201R	KLK3_uc010ycj.1_Silent_p.R160R|KLK3_uc002ptr.1_Silent_p.R158R|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	201	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		GTGCTGGACGCTGGACAGGGG	0.527	Colon(185;1767 2023 13025 30120 37630)		NA											48	39					0	0	0.00361	0	0
AGBL5	60509	broad.mit.edu	37	2	27281274	27281274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr2:27281274C>T	uc002rie.2	+	10	1895	c.1678C>T	c.(1678-1680)CGA>TGA	p.R560*	AGBL5_uc002rid.2_Nonsense_Mutation_p.R560*|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	560					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGGTGGGACGAGCTATGGC	0.582			NA											16	33					0	0	0.006122	0	0
CLASP1	23332	broad.mit.edu	37	2	122139812	122139812	+	Missense_Mutation	SNP	T	T	C			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr2:122139812T>C	uc002tnc.2	-	32	3853	c.3463A>G	c.(3463-3465)AAG>GAG	p.K1155E	CLASP1_uc010yyv.1_Intron|CLASP1_uc002tmz.2_Missense_Mutation_p.K240E|CLASP1_uc002tna.2_Intron|CLASP1_uc010yyw.1_Intron|CLASP1_uc002tnb.2_Intron|CLASP1_uc010yyx.1_Intron|CLASP1_uc010yyy.1_Intron|CLASP1_uc010yyz.1_Intron|CLASP1_uc010yza.1_Intron|CLASP1_uc010yzb.1_Intron|CLASP1_uc010yzc.1_Intron|CLASP1_uc002tnf.2_Intron	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1155					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					CTGAGAGCCTTGTGGGAGGGA	0.532			NA											4	11					0	0	0.000248	0	0
FRG1B	284802	broad.mit.edu	37	20	29614328	29614328	+	Splice_Site	SNP	G	G	A	rs137860963	by1000genomes	TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr20:29614328G>A	uc010ztk.1	+	1	67	c.-6_splice	c.e1+1		FRG1B_uc002wvm.1_Splice_Site|FRG1B_uc010ztj.1_Splice_Site|FRG1B_uc010gdr.1_Splice_Site					RecName: Full=Protein FRG1B;												0						TGATACGTTGGTGAGTCAGTT	0.219			NA											5	82					0	0	0.00308	0	0
FAM83C	128876	broad.mit.edu	37	20	33876276	33876276	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr20:33876276G>A	uc010zux.1	-	3	912	c.794C>T	c.(793-795)GCG>GTG	p.A265V	FAM83C_uc002xcb.1_Intron	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	265										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GTAACTGCCCGCCACCACTTG	0.592			NA											19	41					0	0	0.001882	0	0
BLCAP	10904	broad.mit.edu	37	20	36147457	36147457	+	Silent	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr20:36147457C>T	uc002xha.2	-	2	323	c.120G>A	c.(118-120)CGG>CGA	p.R40R	BLCAP_uc002xhb.2_Silent_p.R40R|BLCAP_uc002xhc.2_Silent_p.R40R|NNAT_uc002xhd.2_5'Flank|NNAT_uc002xhe.2_5'Flank	NM_006698	NP_006689	P62952	BLCAP_HUMAN	bladder cancer associated protein	40					apoptosis|cell cycle	integral to membrane					0		Myeloproliferative disorder(115;0.00878)				TGCAAGGCTTCCGTTCCAGGA	0.567			NA											5	28					0	0	0.000602	0	0
RFPL1	5988	broad.mit.edu	37	22	29837625	29837625	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr22:29837625G>A	uc003afn.2	+	2	677	c.468G>A	c.(466-468)CGG>CGA	p.R156R	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	156	B30.2/SPRY.						zinc ion binding				0						CACAGAATCGGCAAGACCTTG	0.557			NA											4	81					0	0	0.000602	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37499438	37499438	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr22:37499438G>A	uc003aqs.1	-	2	161	c.47C>T	c.(46-48)CCC>CTC	p.P16L	TMPRSS6_uc003aqt.1_Missense_Mutation_p.P7L|TMPRSS6_uc003aqu.2_Missense_Mutation_p.P7L	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	16	Cytoplasmic (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity	p.P16fs*12(1)		breast(4)|ovary(1)|skin(1)	6						AGCCACCTGGGGGGCCTCGGC	0.657			NA											27	93					0	0	0.001271	0	0
DHX30	22907	broad.mit.edu	37	3	47859533	47859533	+	Missense_Mutation	SNP	G	G	A	rs138729543		TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr3:47859533G>A	uc003cru.2	+	4	476	c.50G>A	c.(49-51)CGT>CAT	p.R17H	DHX30_uc003crs.2_5'UTR|DHX30_uc003crt.2_5'UTR	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	17						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		cacaggcagcgtcagtgcaaa	0.164			NA											27	87					0	0	0.002445	0	0
PTPRG	5793	broad.mit.edu	37	3	62254711	62254711	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr3:62254711G>A	uc003dlb.2	+	20	3595	c.2876G>A	c.(2875-2877)CGA>CAA	p.R959Q	PTPRG_uc003dlc.2_Missense_Mutation_p.R930Q|PTPRG_uc011bfi.1_Missense_Mutation_p.R205Q|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	959	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TTTCTGCAGCGAAAATGTGAT	0.363			NA											5	50					0	0	0.001984	0	0
P2RY1	5028	broad.mit.edu	37	3	152553609	152553609	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr3:152553609C>T	uc003ezq.2	+	1	874	c.38C>T	c.(37-39)ACG>ATG	p.T13M		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	13	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			CCCAACGGGACGGACGCTGCC	0.692			NA											4	32					0	0	0.000248	0	0
SKIL	6498	broad.mit.edu	37	3	170078422	170078422	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr3:170078422G>A	uc003fgu.2	+	2	1015	c.303G>A	c.(301-303)CTG>CTA	p.L101L	SKIL_uc011bps.1_Silent_p.L81L|SKIL_uc003fgv.2_Silent_p.L101L|SKIL_uc003fgw.2_Silent_p.L101L	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	101					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			AGAGCTCGCTGGGTGGACCAG	0.463			NA											59	214					0	0	0.00361	0	0
CHRD	8646	broad.mit.edu	37	3	184103862	184103862	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr3:184103862C>T	uc003fov.2	+	15	2093	c.1847C>T	c.(1846-1848)CCG>CTG	p.P616L	CHRD_uc003fow.2_Missense_Mutation_p.P246L|CHRD_uc003fox.2_Missense_Mutation_p.P616L|CHRD_uc003foy.2_Missense_Mutation_p.P246L|CHRD_uc010hyc.2_Missense_Mutation_p.P206L|CHRD_uc011brr.1_Missense_Mutation_p.P246L	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	616	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GACCTGGAGCCGGAACTGCTG	0.502			NA											5	94					0	0	0.001168	0	0
NFKB1	4790	broad.mit.edu	37	4	103498166	103498166	+	Missense_Mutation	SNP	G	G	C			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr4:103498166G>C	uc011ceq.1	+	7	1005	c.538G>C	c.(538-540)GCA>CCA	p.A180P	NFKB1_uc011cep.1_Missense_Mutation_p.A181P|NFKB1_uc011cer.1_5'Flank	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	180	RHD.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	CTATTTGCAAGCAGAAGGTGG	0.483			NA											29	72					0	0	0.001786	0	0
GALNT7	51809	broad.mit.edu	37	4	174213396	174213396	+	Missense_Mutation	SNP	T	T	C			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr4:174213396T>C	uc003isz.3	+	3	808	c.725T>C	c.(724-726)ATT>ACT	p.I242T	GALNT7_uc011ckb.1_Missense_Mutation_p.I19T	NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	242	Catalytic subdomain A.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		TTAGCAGAAATTGTGTTAATT	0.343			NA											15	36					0	0	0.003163	0	0
SLC12A7	10723	broad.mit.edu	37	5	1083938	1083938	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr5:1083938C>T	uc003jbu.2	-	8	1117	c.1051G>A	c.(1051-1053)GCC>ACC	p.A351T		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	351					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TCGTCACAGGCGGCGCTGGGC	0.647			NA											15	42					0	0	0.00245	0	0
OSMR	9180	broad.mit.edu	37	5	38885486	38885486	+	Missense_Mutation	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr5:38885486A>G	uc003jln.1	+	6	1106	c.739A>G	c.(739-741)ACC>GCC	p.T247A	OSMR_uc003jlm.1_Missense_Mutation_p.T247A	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	247	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					TTCTTGTGAAACCGAGGACTT	0.428			NA											33	68					0	0	0.002445	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54649009	54649009	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr5:54649009C>T	uc003jpy.3	+	14	1711	c.1445C>T	c.(1444-1446)ACG>ATG	p.T482M	SKIV2L2_uc011cqi.1_Missense_Mutation_p.T381M	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	482	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTATTTGCCACGGAGACCTTT	0.318	Melanoma(2;92 134 23744 29976 33782)		NA											8	157					0	0	0.000978	0	0
ERAP2	64167	broad.mit.edu	37	5	96253168	96253168	+	Silent	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr5:96253168G>A	uc003kmq.2	+	19	3452	c.2742G>A	c.(2740-2742)GTG>GTA	p.V914V	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Silent_p.V914V|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Silent_p.V863V|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	914	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TTTTACAGGTGAAACTATTTT	0.219			NA											25	48					0	0	0.003954	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625383	140625383	+	Silent	SNP	G	G	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr5:140625383G>T	uc003lje.2	+	1	237	c.237G>T	c.(235-237)CTG>CTT	p.L79L		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	79	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCTTGATCTGCAGACCGGGC	0.537			NA											19	41					1.33834e-09	3.34584e-09	0.000958	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140798770	140798770	+	Silent	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr5:140798770C>T	uc003lkn.1	+	1	1489	c.1344C>T	c.(1342-1344)AAC>AAT	p.N448N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Silent_p.N448N|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	448	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAATGACAACGCGCCGGTTT	0.572			NA											14	28					0	0	0.001855	0	0
RBM27	54439	broad.mit.edu	37	5	145649137	145649137	+	Missense_Mutation	SNP	C	C	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr5:145649137C>A	uc003lnz.3	+	17	2847	c.2681C>A	c.(2680-2682)ACA>AAA	p.T894K	RBM27_uc003lny.2_Missense_Mutation_p.T839K	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	894					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGTGAAGACAAAAACGGAG	0.209			NA											23	14					5.45024e-15	1.37822e-14	0.00333	1	0
DNAH8	1769	broad.mit.edu	37	6	38919259	38919259	+	Silent	SNP	C	C	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr6:38919259C>A	uc003ooe.1	+	80	12363	c.11763C>A	c.(11761-11763)ACC>ACA	p.T3921T	DNAH8_uc003oog.1_Silent_p.T370T|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CTGACCCCACCAATCAAATTG	0.413			NA											18	492					2.94398e-08	7.1964e-08	0.000958	1	0
COL19A1	1310	broad.mit.edu	37	6	70637868	70637868	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr6:70637868G>A	uc003pfc.1	+	5	451	c.334G>A	c.(334-336)GCC>ACC	p.A112T	COL19A1_uc010kam.1_Missense_Mutation_p.A8T	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	112	TSP N-terminal.			FRVRRNAKKERWFL -> ETTVPFWRFFVLET (in Ref. 6; AAA36358).	cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ACGAAGAAACGCCAAAAAGGA	0.428			NA											35	63					0	0	0.002836	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599486	136599486	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr6:136599486G>A	uc003qgx.1	-	4	786	c.533C>T	c.(532-534)CCG>CTG	p.P178L	BCLAF1_uc003qgw.1_Missense_Mutation_p.P178L|BCLAF1_uc003qgy.1_Missense_Mutation_p.P176L|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.P176L	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	178					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ACTTTTCAACGGACTCTCTTC	0.418	Colon(142;1534 1789 5427 7063 28491)		NA											30	257					0	0	0.001512	0	0
GARS	2617	broad.mit.edu	37	7	30639610	30639610	+	Missense_Mutation	SNP	G	G	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr7:30639610G>A	uc003tbm.2	+	3	729	c.372G>A	c.(370-372)ATG>ATA	p.M124I		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	124					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	GAGCAAAAATGGAAGATACCC	0.408			NA											28	177					0	0	0.002445	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657788	72657788	+	Missense_Mutation	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr7:72657788A>G	uc003txs.1	-	13	2124	c.1196T>C	c.(1195-1197)CTA>CCA	p.L399P	FKBP6_uc003twz.2_Intron	NR_002164				RecName: Full=General transcription factor II-I repeat domain-containing protein 2B; AltName: Full=GTF2I repeat domain-containing protein 2B; AltName: Full=Transcription factor GTF2IRD2-beta;												0						cagttttgctaggaacacccg	0			NA											60	306					0	0	0.00361	0	0
CNOT4	4850	broad.mit.edu	37	7	135048808	135048808	+	Missense_Mutation	SNP	A	A	C			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr7:135048808A>C	uc011kpy.1	-	10	1730	c.1638T>G	c.(1636-1638)AGT>AGG	p.S546R	CNOT4_uc003vss.2_Intron|CNOT4_uc011kpz.1_Missense_Mutation_p.S543R|CNOT4_uc003vst.2_Intron	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						TCTCTACAGAACTGCTGTTGT	0.383	Ovarian(51;766 1130 5502 35047 50875)		NA											12	270					0	0	0.001855	0	0
MKRN1	23608	broad.mit.edu	37	7	140154416	140154416	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr7:140154416C>T	uc003vvt.2	-	8	1575	c.1350G>A	c.(1348-1350)ATG>ATA	p.M450I	MKRN1_uc003vvs.2_Missense_Mutation_p.M386I|MKRN1_uc011krd.1_Missense_Mutation_p.M184I	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	450							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					CAGCCAAAAGCATAAGCAACA	0.463			NA											19	77					0	0	0.001216	0	0
GTF2E2	2961	broad.mit.edu	37	8	30464636	30464636	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr8:30464636C>T	uc003xig.2	-	6	834	c.581G>A	c.(580-582)CGT>CAT	p.R194H		NM_002095	NP_002086	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2,	194					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		CTTATCGGGACGATTTACAAA	0.303			NA											23	91					0	0	0.004656	0	0
LYN	4067	broad.mit.edu	37	8	56910924	56910924	+	Missense_Mutation	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr8:56910924A>G	uc003xsk.3	+	11	1352	c.1070A>G	c.(1069-1071)TAC>TGC	p.Y357C	LYN_uc003xsl.3_Missense_Mutation_p.Y336C	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	357	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GGAATGGCATACATCGAGCGG	0.458			NA											4	64					0	0	0.000248	0	0
VPS13B	157680	broad.mit.edu	37	8	100866351	100866351	+	Silent	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr8:100866351C>T	uc003yiv.2	+	56	10920	c.10809C>T	c.(10807-10809)CTC>CTT	p.L3603L	VPS13B_uc003yiw.2_Silent_p.L3578L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3603					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ACGCTTCCCTCAAGCTGTACA	0.547	Colon(161;2205 2542 7338 31318)		NA											63	51					0	0	0.00361	0	0
KLHL9	55958	broad.mit.edu	37	9	21334730	21334730	+	Silent	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr9:21334730A>G	uc003zoy.2	-	1	700	c.129T>C	c.(127-129)CTT>CTC	p.L43L	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	43					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		CTTCTATTCTAAGCTGATCAA	0.468			NA											42	48					0	0	0.001951	0	0
LOC442421	442421	broad.mit.edu	37	9	66499680	66499680	+	Missense_Mutation	SNP	C	C	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr9:66499680C>A	uc004aee.1	+	1	490	c.490C>A	c.(490-492)CCC>ACC	p.P164T	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						TCATGTTAACCCCTTCCCAGG	0.582			NA											5	43					1.23904e-05	2.93106e-05	0.000602	1	0
LOC442421	442421	broad.mit.edu	37	9	66499794	66499794	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr9:66499794C>T	uc004aee.1	+	1	604	c.604C>T	c.(604-606)CGC>TGC	p.R202C	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						GTGCAAGTCGCGCAAGGAGCA	0.587			NA											5	83					0	0	0.001855	0	0
OTUD5	55593	broad.mit.edu	37	X	48791832	48791832	+	Missense_Mutation	SNP	C	C	A			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chrX:48791832C>A	uc004dlu.2	-	5	1040	c.979G>T	c.(979-981)GTT>TTT	p.V327F	OTUD5_uc004dlt.3_Missense_Mutation_p.V322F|OTUD5_uc004dlv.2_Missense_Mutation_p.V322F|OTUD5_uc011mmp.1_Missense_Mutation_p.V105F	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	327	OTU.				negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						TGGTAGCTAACACGAATGGGT	0.512			NA											5	85					0.000602214	0.00140944	0.000602	1	0
TAF1	6872	broad.mit.edu	37	X	70613945	70613945	+	Missense_Mutation	SNP	A	A	G			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chrX:70613945A>G	uc004dzu.3	+	22	3304	c.3253A>G	c.(3253-3255)ACT>GCT	p.T1085A	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.T1106A|TAF1_uc004dzv.3_Missense_Mutation_p.T259A	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1085					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AGTCTTATCAACTGACACAGA	0.383			NA											4	44					0	0	0.000248	0	0
POF1B	79983	broad.mit.edu	37	X	84634283	84634283	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chrX:84634283C>T	uc004eer.2	-	2	323	c.177G>A	c.(175-177)ATG>ATA	p.M59I	POF1B_uc004ees.2_Missense_Mutation_p.M59I	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	59							actin binding				0						CCACCTTGTTCATGGGCCCAC	0.532			NA											4	47					0	0	0.000248	0	0
GPC4	2239	broad.mit.edu	37	X	132439841	132439841	+	Missense_Mutation	SNP	C	C	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chrX:132439841C>T	uc004exc.1	-	6	1326	c.1114G>A	c.(1114-1116)GAA>AAA	p.E372K	GPC4_uc011mvg.1_Missense_Mutation_p.E302K	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	372					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					GTTGGGCGTTCCTCGGGGTGA	0.552			NA											29	301					0	0	0.001512	0	0
FREM2	341640	broad.mit.edu	37	13	39261568	39261570	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	GCT	GCT	-	-	GCT	GCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr13:39261568_39261570delGCT	uc001uwv.2	+	1	396_398	c.87_89delGCT	c.(85-90)CGGCTG>CGG	p.L38del		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	38					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CGCCGCCCCGgctgctgctgctg	0.626			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
CCDC88A	55704	broad.mit.edu	37	2	55555500	55555501	+	Frame_Shift_Ins	INS	-	-	T			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr2:55555500_55555501insT	uc002ryv.2	-	17	3765_3766	c.2923_2924insA	c.(2923-2925)ATTfs	p.I975fs	CCDC88A_uc010yoz.1_Frame_Shift_Ins_p.I976fs|CCDC88A_uc010ypa.1_Frame_Shift_Ins_p.I975fs|CCDC88A_uc002ryu.2_Frame_Shift_Ins_p.I258fs|CCDC88A_uc002rys.2_5'UTR|CCDC88A_uc002ryw.2_Frame_Shift_Ins_p.I259fs|CCDC88A_uc010fby.1_5'UTR	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	976	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TAAAGCAGCAATTTTTTCTTCT	0.307			NA											14	26	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	4	119434815	119434822	+	Frame_Shift_Del	DEL	AGAGCCAC	AGAGCCAC	-			TCGA-71-6725-01A-11D-1855-08	TCGA-71-6725-10A-01D-1855-08	AGAGCCAC	AGAGCCAC	-	-	AGAGCCAC	AGAGCCAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3a146eb4-7b9b-4834-b3d0-eac80f9173ec	056f3049-18f0-4c6b-8681-f4b11908fb53	g.chr4:119434815_119434822delAGAGCCAC	uc010imy.1	+	2	170_177	c.101_108delAGAGCCAC	c.(100-108)GAGAGCCACfs	p.E34fs	CEP170L_uc003icb.2_5'Flank					Homo sapiens cDNA, FLJ98257.												NA						AAGTCTCTTGAGAGCCACAGAGCAAAGG	0.452			NA											9	43	---	---	---	---	NA	NA	NA	NA	NA