Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRDM16	63976	broad.mit.edu	37	1	3328444	3328444	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:3328444C>T	uc001akf.2	+	9	1763	c.1683C>T	c.(1681-1683)GCC>GCT	p.A561A	PRDM16_uc001akc.2_Silent_p.A561A|PRDM16_uc001akd.2_Silent_p.A561A|PRDM16_uc001ake.2_Silent_p.A561A|PRDM16_uc009vlh.2_Silent_p.A262A	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	561					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGGTCTCCGCCGTCAGCAACA	0.667			NA	T	EVI1	MDS|AML								5	48					0	0	0.000602	0	0
NOL9	79707	broad.mit.edu	37	1	6585920	6585920	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:6585920C>T	uc001ans.2	-	12	2122	c.2103G>A	c.(2101-2103)ATG>ATA	p.M701I	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	701					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		AGCATCACTTCATTTTTCGAC	0.418			NA											13	190					0	0	0.00245	0	0
NOL9	79707	broad.mit.edu	37	1	6585979	6585979	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:6585979C>T	uc001ans.2	-	12	2063	c.2044G>A	c.(2044-2046)GAA>AAA	p.E682K	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	682					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTCAGGTTCTCTTGCTCCA	0.418			NA											14	170					0	0	0.001855	0	0
DFFA	1676	broad.mit.edu	37	1	10527261	10527261	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:10527261C>G	uc001arj.2	-	3	525	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	DFFA_uc001ark.2_Missense_Mutation_p.E143Q	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	143					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGGTCCTCCTCTGATAGGAGG	0.532			NA											10	92					0	0	0.006214	0	0
ACTL8	81569	broad.mit.edu	37	1	18152600	18152600	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:18152600G>A	uc001bat.2	+	3	903	c.687G>A	c.(685-687)CAG>CAA	p.Q229Q		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	229						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		AGAGGCAGCAGAGTGCCTTGG	0.607			NA									OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	59					0	0	0.001168	0	0
TIE1	7075	broad.mit.edu	37	1	43775098	43775098	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:43775098G>C	uc001ciu.2	+	9	1307	c.1228G>C	c.(1228-1230)GAG>CAG	p.E410Q	TIE1_uc010okd.1_Missense_Mutation_p.E410Q|TIE1_uc010oke.1_Missense_Mutation_p.E365Q|TIE1_uc009vwq.2_Missense_Mutation_p.E366Q|TIE1_uc010okf.1_Missense_Mutation_p.E55Q|TIE1_uc010okg.1_Missense_Mutation_p.E55Q|TIE1_uc010okc.1_Nonstop_Mutation_p.*318S	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	410	Ig-like C2-type 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GACCACAGCTGAGTTCGAGGT	0.607			NA											5	29					0	0	0.001168	0	0
GLIS1	148979	broad.mit.edu	37	1	54060157	54060157	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:54060157C>T	uc001cvr.1	-	3	986	c.419G>A	c.(418-420)CGG>CAG	p.R140Q		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	140					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						GCTCGCCTTCCGGCAGGCTTC	0.657			NA											4	38					0	0	0.009096	0	0
C8A	731	broad.mit.edu	37	1	57347292	57347292	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:57347292G>A	uc001cyo.2	+	5	771	c.639G>A	c.(637-639)CTG>CTA	p.L213L		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	213	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						ACAACTTTCTGAAGTACCACT	0.478			NA											12	84					0	0	0.001368	0	0
LPHN2	23266	broad.mit.edu	37	1	82456132	82456132	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:82456132G>T	uc001dit.3	+	21	3696	c.3515G>T	c.(3514-3516)GGT>GTT	p.G1172V	LPHN2_uc001dis.2_Missense_Mutation_p.G152V|LPHN2_uc001diu.2_Missense_Mutation_p.G1172V|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.G799V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1228	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CCGCTAAATGGTAATTTTAAC	0.433			NA											17	129					2.5808e-16	3.66335e-16	0.006122	1	0
WDR63	126820	broad.mit.edu	37	1	85559237	85559237	+	Silent	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:85559237C>G	uc001dkt.2	+	9	1145	c.954C>G	c.(952-954)ACC>ACG	p.T318T	WDR63_uc009wcl.2_Silent_p.T279T	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	318										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		GGGACAAGACCGATACCCACC	0.438			NA											11	136					0	0	0.001368	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94337653	94337653	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:94337653C>T	uc001dqf.2	-	5	2080	c.2042G>A	c.(2041-2043)AGA>AAA	p.R681K	DNTTIP2_uc010otm.1_RNA	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	681					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		GAAGCCATCTCTATCATTTTT	0.373			NA											33	315					0	0	0.002836	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94337751	94337751	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:94337751C>G	uc001dqf.2	-	5	1982	c.1944G>C	c.(1942-1944)ATG>ATC	p.M648I	DNTTIP2_uc010otm.1_RNA	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	648				M -> I (in Ref. 6; BAD96442).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		CTGGAGCTTTCATACCAAACC	0.343			NA											7	137					0	0	0.00308	0	0
CNN3	1266	broad.mit.edu	37	1	95368680	95368680	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:95368680G>A	uc010otw.1	-	4	326	c.244C>T	c.(244-246)CAG>TAG	p.Q82*	CNN3_uc010otv.1_Nonsense_Mutation_p.Q41*|CNN3_uc001dqz.3_Nonsense_Mutation_p.Q82*|CNN3_uc010otx.1_Nonsense_Mutation_p.Q82*	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	82	CH.				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		GCTGTTACCTGAGGCCAGTTC	0.383			NA											9	84					0	0	0.006214	0	0
PRPF38B	55119	broad.mit.edu	37	1	109242068	109242068	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:109242068G>C	uc001dvv.3	+	6	1349	c.1067G>C	c.(1066-1068)AGA>ACA	p.R356T	PRPF38B_uc001dvw.3_Missense_Mutation_p.R245T|PRPF38B_uc010ouz.1_Missense_Mutation_p.R159T	NM_018061	NP_060531	Q5VTL8	PR38B_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)	356	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex					0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		gatcgagaaagagagaaagaa	0.219			NA											3	18					0	0	0.004672	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144865913	144865913	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:144865913G>A	uc001elw.3	-	35	5958	c.5667C>T	c.(5665-5667)TTC>TTT	p.F1889F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.F1783F|PDE4DIP_uc001elv.3_Silent_p.F896F|PDE4DIP_uc001ema.2_Silent_p.F76F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1889	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCTGACTGTAGAAGTTAGAAG	0.458			NA	T	PDGFRB	MPD								17	397					0	0	0.007413	0	0
CGN	57530	broad.mit.edu	37	1	151509762	151509762	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:151509762C>T	uc009wmw.2	+	21	3696	c.3552C>T	c.(3550-3552)TAC>TAT	p.Y1184Y	CGN_uc010pde.1_Silent_p.Y178Y	NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	1178	Tail.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACAGTGTCTACGATCCCTCGT	0.537			NA											4	54					0	0	0.001984	0	0
SCAMP3	10067	broad.mit.edu	37	1	155228742	155228742	+	Missense_Mutation	SNP	C	C	T	rs143130366	byFrequency	TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:155228742C>T	uc001fjs.2	-	5	645	c.392G>A	c.(391-393)CGA>CAA	p.R131Q	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjr.2_5'UTR|SCAMP3_uc001fju.2_Intron|SCAMP3_uc001fjv.2_Missense_Mutation_p.R131Q|SCAMP3_uc001fjt.2_Missense_Mutation_p.R105Q	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	131	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ATTGTTCTGTCGAGCTGTAAG	0.463			NA											34	76					0	0	0.003755	0	0
PKLR	5313	broad.mit.edu	37	1	155271149	155271149	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:155271149C>A	uc001fkb.3	-	1	77	c.38G>T	c.(37-39)CGG>CTG	p.R13L	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_5'Flank|PKLR_uc010pga.1_5'Flank	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	13					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GACCCATGACCGAAGCTGCAG	0.532			NA											21	60					1.01871e-10	1.36799e-10	0.008871	1	0
ASH1L	55870	broad.mit.edu	37	1	155317620	155317620	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:155317620C>T	uc009wqq.2	-	20	8125	c.7645G>A	c.(7645-7647)GAG>AAG	p.E2549K	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.E2544K|MIR555_hsa-mir-555|MI0003561_5'Flank	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2549					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GCTGATGCCTCATGCCGGGCA	0.473			NA											13	148					0	0	0.001855	0	0
OR10K1	391109	broad.mit.edu	37	1	158435885	158435885	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:158435885C>T	uc010pij.1	+	1	534	c.534C>T	c.(532-534)TTC>TTT	p.F178F		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ATCACTTCTTCTGTGACATCT	0.532			NA											56	152					0	0	0.00361	0	0
OR10K1	391109	broad.mit.edu	37	1	158436017	158436017	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:158436017C>A	uc010pij.1	+	1	666	c.666C>A	c.(664-666)ATC>ATA	p.I222I		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCCGCATCATCTCTGCCATTC	0.478			NA											20	71					7.45023e-12	1.01333e-11	0.010504	1	0
SPTA1	6708	broad.mit.edu	37	1	158636110	158636110	+	Missense_Mutation	SNP	C	C	T	rs145972324	by1000genomes	TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:158636110C>T	uc001fst.1	-	16	2415	c.2216G>A	c.(2215-2217)CGT>CAT	p.R739H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	739	Spectrin 8.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACAAACCTGACGAGCAGCCAC	0.463			NA											4	19					0	0	0.000602	0	0
C1orf129	80133	broad.mit.edu	37	1	170952642	170952642	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:170952642G>T	uc001ghg.2	+	9	826	c.696G>T	c.(694-696)AAG>AAT	p.K232N	C1orf129_uc009wvy.2_Missense_Mutation_p.K39N|C1orf129_uc010plz.1_Missense_Mutation_p.K232N	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	232							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCTACCCAAGGAGTTTCAAC	0.363			NA											11	55					0.000151284	0.000169295	0.001855	1	0
ABL2	27	broad.mit.edu	37	1	179087822	179087822	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:179087822C>A	uc001gmj.3	-	7	1410	c.1123G>T	c.(1123-1125)GAA>TAA	p.E375*	ABL2_uc010pnf.1_Nonsense_Mutation_p.E375*|ABL2_uc010png.1_Nonsense_Mutation_p.E354*|ABL2_uc010pnh.1_Nonsense_Mutation_p.E354*|ABL2_uc009wxe.2_Nonsense_Mutation_p.E354*|ABL2_uc001gmg.3_Nonsense_Mutation_p.E360*|ABL2_uc001gmi.3_Nonsense_Mutation_p.E360*|ABL2_uc001gmh.3_Nonsense_Mutation_p.E339*|ABL2_uc010pne.1_Nonsense_Mutation_p.E339*|ABL2_uc009wxf.1_Nonsense_Mutation_p.E360*|ABL2_uc001gmk.2_Nonsense_Mutation_p.E339*	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	375	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CGGTTGCATTCTCGGAGGTAA	0.428			NA	T	ETV6	AML								65	137					3.77215e-22	5.44581e-22	0.00361	1	0
SOAT1	6646	broad.mit.edu	37	1	179318019	179318019	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:179318019C>T	uc001gml.2	+	13	1319	c.1256C>T	c.(1255-1257)ACC>ATC	p.T419I	SOAT1_uc010pni.1_Missense_Mutation_p.T354I|SOAT1_uc001gmm.2_Missense_Mutation_p.T361I|SOAT1_uc010pnj.1_Missense_Mutation_p.T155I|SOAT1_uc010pnk.1_Missense_Mutation_p.T354I	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	419					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	TATTATAGAACCTGGAATGTG	0.318			NA											11	184					0	0	0.010729	0	0
ELK4	2005	broad.mit.edu	37	1	205589516	205589516	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:205589516C>A	uc001hcy.1	-	3	1908	c.658G>T	c.(658-660)GAA>TAA	p.E220*	ELK4_uc001hcz.2_Nonsense_Mutation_p.E220*	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	220						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TGGATAGTTTCTTCTGAAGAT	0.473			NA	T	SLC45A3	prostate								19	76					7.07596e-05	8.00302e-05	0.006122	1	0
ELK4	2005	broad.mit.edu	37	1	205589655	205589655	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:205589655C>T	uc001hcy.1	-	3	1769	c.519G>A	c.(517-519)GAG>GAA	p.E173E	ELK4_uc001hcz.2_Silent_p.E173E	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	173						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CTGCCAGTTTCTCGGCTGGAT	0.423			NA	T	SLC45A3	prostate								14	59					0	0	0.00245	0	0
ELK4	2005	broad.mit.edu	37	1	205589806	205589806	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:205589806C>G	uc001hcy.1	-	3	1618	c.368G>C	c.(367-369)GGA>GCA	p.G123A	ELK4_uc001hcz.2_Missense_Mutation_p.G123A	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	123						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			ATCTTTCCCTCCATTCTCCAC	0.438			NA	T	SLC45A3	prostate								18	57					0	0	0.010504	0	0
USH2A	7399	broad.mit.edu	37	1	216595491	216595491	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:216595491C>G	uc001hku.1	-	2	575	c.188G>C	c.(187-189)CGA>CCA	p.R63P	USH2A_uc001hkv.2_Missense_Mutation_p.R63P	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	63	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAAAGTGCTTCGGTCTGGGAG	0.493			NA								HNSCC(13;0.011)			19	37					0	0	0.007413	0	0
DUSP10	11221	broad.mit.edu	37	1	221879756	221879756	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:221879756G>A	uc001hmy.1	-	3	1046	c.864C>T	c.(862-864)CTC>CTT	p.L288L	DUSP10_uc001hmx.1_5'UTR|DUSP10_uc001hmz.1_5'UTR	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	288					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		CTTGGAGCTGGAGGGAGTTGT	0.567			NA											5	91					0	0	0.000602	0	0
URB2	9816	broad.mit.edu	37	1	229773573	229773573	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:229773573C>T	uc001hts.1	+	4	3349	c.3213C>T	c.(3211-3213)CTC>CTT	p.L1071L	URB2_uc009xfd.1_Silent_p.L1071L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1071						nucleolus				central_nervous_system(2)|ovary(1)	3						GACCTTTCCTCAAAGAGCAGA	0.562			NA											22	60					0	0	0.002299	0	0
DISC1	27185	broad.mit.edu	37	1	231830502	231830502	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:231830502G>T	uc001huz.2	+	2	1051	c.998G>T	c.(997-999)TGG>TTG	p.W333L	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.W288L|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.W288L|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.W322L|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.W288L|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.W288L|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.W322L|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.W322L|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.W333L|DISC1_uc010pwp.1_Missense_Mutation_p.W333L|DISC1_uc010pwq.1_Missense_Mutation_p.W333L|DISC1_uc010pwr.1_Missense_Mutation_p.W333L|DISC1_uc010pws.1_Missense_Mutation_p.W333L|DISC1_uc010pwt.1_Missense_Mutation_p.W333L|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.W333L|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.W333L|DISC1_uc010pxb.1_Missense_Mutation_p.W333L|DISC1_uc010pxc.1_Missense_Mutation_p.W333L|DISC1_uc010pxd.1_Missense_Mutation_p.M1I|DISC1_uc010pxe.1_Missense_Mutation_p.W333L|DISC1_uc009xfr.2_Missense_Mutation_p.W288L|DISC1_uc010pxf.1_Missense_Mutation_p.W333L|DISC1_uc010pxg.1_Missense_Mutation_p.W333L|DISC1_uc010pxh.1_Missense_Mutation_p.W333L|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Missense_Mutation_p.M1I|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.W333L|DISC1_uc010pxn.1_Missense_Mutation_p.M1I|DISC1_uc001hva.2_Missense_Mutation_p.W333L|DISC1_uc010pwm.1_Missense_Mutation_p.W333L|DISC1_uc001hux.1_Missense_Mutation_p.W333L|DISC1_uc001hvc.3_Missense_Mutation_p.W333L|DISC1_uc010pwn.1_Missense_Mutation_p.W333L	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	333	Interaction with TRAF3IP1.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				CTCAGGAAATGGGAGCCAGTG	0.607			NA											13	28					1.5842e-08	2.04929e-08	0.001855	1	0
NID1	4811	broad.mit.edu	37	1	236212121	236212121	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:236212121G>A	uc001hxo.2	-	2	496	c.394C>T	c.(394-396)CAG>TAG	p.Q132*	NID1_uc009xgd.2_Nonsense_Mutation_p.Q132*	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	132	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCTGCTCGCTGAGTGATGGAG	0.577			NA											4	38					0	0	0.009096	0	0
RYR2	6262	broad.mit.edu	37	1	237886466	237886466	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:237886466C>T	uc001hyl.1	+	74	10713	c.10593C>T	c.(10591-10593)TAC>TAT	p.Y3531Y	RYR2_uc010pxz.1_Silent_p.Y486Y	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3531					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGCTCTTTACAAAGACTTAC	0.388			NA											17	171					0	0	0.006122	0	0
HNRNPU	3192	broad.mit.edu	37	1	245023749	245023749	+	Nonsense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:245023749G>C	uc001iaz.1	-	4	1123	c.905C>G	c.(904-906)TCA>TGA	p.S302*	HNRNPU_uc001iaw.1_5'Flank|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Nonsense_Mutation_p.S26*|HNRNPU_uc001iba.1_Nonsense_Mutation_p.S283*|HNRNPU_uc001ibb.1_Translation_Start_Site	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	302	B30.2/SPRY.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			ACGATCTCTTGATATTTTAAA	0.358	NSCLC(33;911 1010 3329 23631 49995)		NA											4	49					0	0	0.000602	0	0
CNST	163882	broad.mit.edu	37	1	246823523	246823523	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:246823523T>C	uc001ibp.2	+	10	2237	c.1859T>C	c.(1858-1860)GTC>GCC	p.V620A		NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	620					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						GAAGGATTGGTCTCCATATTA	0.378			NA											9	194					0	0	0.004482	0	0
OR2L13	284521	broad.mit.edu	37	1	248262905	248262905	+	Silent	SNP	C	C	A	rs139493421		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:248262905C>A	uc001ids.2	+	3	565	c.228C>A	c.(226-228)ACC>ACA	p.T76T		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TCTCCACCACCGTCCCCAAGA	0.537			NA											80	133					1.45872e-26	2.12771e-26	0.00361	1	0
OR2M7	391196	broad.mit.edu	37	1	248487558	248487558	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:248487558T>C	uc010pzk.1	-	1	313	c.313A>G	c.(313-315)ATA>GTA	p.I105V		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGCAATGATATATAGAAGAAA	0.463			NA											32	262					0	0	0.012213	0	0
OR2T27	403239	broad.mit.edu	37	1	248813843	248813843	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:248813843G>T	uc010pzo.1	-	1	343	c.343C>A	c.(343-345)CTA>ATA	p.L115I		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGAGTCCTAGGAGGAAGAAC	0.547			NA											16	25					1.96292e-10	2.61929e-10	0.010504	1	0
PGBD2	267002	broad.mit.edu	37	1	249212112	249212112	+	Silent	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:249212112G>C	uc001ifh.2	+	3	1476	c.1329G>C	c.(1327-1329)ACG>ACC	p.T443T	PGBD2_uc001ifg.2_Silent_p.T192T|PGBD2_uc009xhd.2_Silent_p.T440T	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	443										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CAGCTAAAACGCGGACTCAGG	0.542			NA											13	18					0	0	0.001368	0	0
DIP2C	22982	broad.mit.edu	37	10	323340	323340	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:323340C>G	uc001ifp.2	-	37	4686	c.4596G>C	c.(4594-4596)GAG>GAC	p.E1532D		NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1532						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TGCGCTGCTTCTCCCCACGGG	0.577			NA											4	39					0	0	0.009096	0	0
MRC1	4360	broad.mit.edu	37	10	17949583	17949583	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:17949583C>G	uc001ipk.2	+	28	4050	c.3947C>G	c.(3946-3948)TCC>TGC	p.S1316C		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	1316	Extracellular (Potential).|C-type lectin 8.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						AGTCCGGTCTCCTTTGTCAAC	0.403	GBM(115;1153 1594 28187 28781 35884)		NA											18	89					0	0	0.00874	0	0
KIAA1217	56243	broad.mit.edu	37	10	24722075	24722075	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:24722075C>T	uc001iru.3	+	4	1108	c.705C>T	c.(703-705)TAC>TAT	p.Y235Y	KIAA1217_uc001irs.2_Silent_p.Y155Y|KIAA1217_uc001irt.3_Silent_p.Y235Y|KIAA1217_uc010qcy.1_Silent_p.Y235Y|KIAA1217_uc010qcz.1_Silent_p.Y235Y|KIAA1217_uc001irv.1_Silent_p.Y85Y|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	235					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TCGCCATTTACATCAAAGATG	0.393			NA											10	89					0	0	0.006214	0	0
ERCC6	2074	broad.mit.edu	37	10	50680512	50680512	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:50680512C>A	uc001jhs.3	-	16	2988	c.2834G>T	c.(2833-2835)CGG>CTG	p.R945L	ERCC6_uc009xod.2_Missense_Mutation_p.R105L|ERCC6_uc010qgr.1_Missense_Mutation_p.R315L|ERCC6_uc001jhr.3_Missense_Mutation_p.R313L	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	945	Helicase C-terminal.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TGCTCGCTCCCGGGCCTGCAA	0.517			NA						Direct_reversal_of_damage|NER					21	106					0.00152264	0.00164305	0.010504	1	0
FAM190B	54462	broad.mit.edu	37	10	86131442	86131442	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:86131442T>C	uc001kdh.1	+	2	828	c.634T>C	c.(634-636)TCT>CCT	p.S212P	FAM190B_uc001kdg.1_Missense_Mutation_p.S212P|FAM190B_uc010qmd.1_Missense_Mutation_p.S212P	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	212										ovary(3)|skin(1)	4						CAGTAGTAAATCTATTAATTG	0.408			NA											6	70					0	0	0.001168	0	0
AGAP11	119385	broad.mit.edu	37	10	88768270	88768270	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:88768270G>T	uc001kee.2	+	12	1465	c.261G>T	c.(259-261)ATG>ATT	p.M87I	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	87					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						AGCAGTCCATGGGCTGGTCCA	0.567			NA											38	188					2.45108e-15	3.46758e-15	0.00874	1	0
PTEN	5728	broad.mit.edu	37	10	89692883	89692883	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:89692883C>T	uc001kfb.2	+	6	1398	c.367C>T	c.(367-369)CAC>TAC	p.H123Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	123	Phosphatase tensin-type.		H -> R (in CD).|H -> Y (in endometrial cancer; loss of protein phosphatase activity).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.H123Y(4)|p.R55fs*1(4)|p.I122fs*2(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.A121_F145del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGCAGCAATTCACTGTAAAGC	0.398			31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			11	104					0	0	0.008291	0	0
EXOC6	54536	broad.mit.edu	37	10	94818035	94818035	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:94818035C>T	uc001kig.2	+	22	2404	c.2338C>T	c.(2338-2340)CGA>TGA	p.R780*	EXOC6_uc010qnr.1_Nonsense_Mutation_p.R796*|EXOC6_uc001kie.2_Nonsense_Mutation_p.R775*|EXOC6_uc009xub.2_Nonsense_Mutation_p.R779*|EXOC6_uc009xuc.2_Nonsense_Mutation_p.R677*|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Nonsense_Mutation_p.R354*|CYP26C1_uc010qns.1_5'Flank|CYP26C1_uc009xud.2_5'Flank	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	780					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				GAAGAATGATCGAGACAAACA	0.383			NA											17	60					0	0	0.004007	0	0
LZTS2	84445	broad.mit.edu	37	10	102763815	102763815	+	Silent	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:102763815G>T	uc001ksj.2	+	3	1029	c.960G>T	c.(958-960)TCG>TCT	p.S320S	LZTS2_uc010qpw.1_Silent_p.S320S|LZTS2_uc001ksk.2_Silent_p.S320S|LZTS2_uc001ksl.2_Silent_p.S320S|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	320	Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		CACCTCCTTCGGATGAGGCCC	0.657	Esophageal Squamous(8;38 437 13604 19902 37640)		NA											12	51					4.3838e-07	5.42207e-07	0.001855	1	0
SORCS3	22986	broad.mit.edu	37	10	106976816	106976816	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:106976816G>T	uc001kyi.1	+	19	2897	c.2670G>T	c.(2668-2670)CAG>CAT	p.Q890H	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	890	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGATCTTCCAGGTGACAGCCT	0.527	NSCLC(116;1497 1690 7108 13108 14106)		NA											9	55					1.76689e-08	2.27172e-08	0.006214	1	0
FAM45A	404636	broad.mit.edu	37	10	120867611	120867611	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr10:120867611C>G	uc001ldw.2	+	2	231	c.187C>G	c.(187-189)CAG>GAG	p.Q63E	FAM45A_uc010qsv.1_Missense_Mutation_p.Q55E|FAM45A_uc010qsw.1_5'UTR|FAM45A_uc010qsx.1_RNA|FAM45A_uc010qsy.1_Intron	NM_207009	NP_996892	Q8TCE6	FA45A_HUMAN	hypothetical protein LOC404636	63										ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		TGTCTTTGGTCAGTACAGAAG	0.388			NA											13	178					0	0	0.003163	0	0
C11orf35	256329	broad.mit.edu	37	11	555798	555798	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:555798G>A	uc001lpx.2	-	12	1573	c.1510C>T	c.(1510-1512)CGC>TGC	p.R504C	uc001lpy.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	504	Pro-rich.									pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGAGGTGGGCGCGGCGGCTTG	0.766			NA											3	7					0	0	0.004672	0	0
PNPLA2	57104	broad.mit.edu	37	11	821651	821651	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:821651G>C	uc001lrt.2	+	3	413	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	PNPLA2_uc009ycl.2_5'Flank	NM_020376	NP_065109	Q96AD5	PLPL2_HUMAN	patatin-like phospholipase domain containing 2	71	Lumenal (Potential).|Patatin.				negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process	integral to membrane|lipid particle|plasma membrane	triglyceride lipase activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.63e-25)|Epithelial(43;1.28e-24)|OV - Ovarian serous cystadenocarcinoma(40;7.09e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAAGTTCATTGAGGTATCTAA	0.597			NA											5	24					0	0	0.000602	0	0
TSSC4	10078	broad.mit.edu	37	11	2424159	2424159	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:2424159G>C	uc001lwj.2	+	4	657	c.296G>C	c.(295-297)TGC>TCC	p.C99S	TSSC4_uc001lwi.2_Missense_Mutation_p.C35S|TSSC4_uc001lwk.2_Missense_Mutation_p.C99S|TSSC4_uc001lwl.2_Missense_Mutation_p.C99S	NM_005706	NP_005697	Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	99											0		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCTTTGACTGCCTGGAGGGG	0.662			NA											2	10					0	0	0.004672	0	0
CREB3L1	90993	broad.mit.edu	37	11	46332651	46332651	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:46332651C>G	uc001ncf.2	+	5	1099	c.664C>G	c.(664-666)CCC>GCC	p.P222A		NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	222	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		CTCCCAGAGTCCCCGCTCTCT	0.677	Pancreas(3;159 194 19597 26278 47995)		NA	T	FUS	myxofibrosarcoma								5	52					0	0	0.000602	0	0
CREB3L1	90993	broad.mit.edu	37	11	46332680	46332680	+	Silent	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:46332680C>G	uc001ncf.2	+	5	1128	c.693C>G	c.(691-693)GTC>GTG	p.V231V		NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	231	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		CCAGCCCTGTCAGGCCCATGG	0.672	Pancreas(3;159 194 19597 26278 47995)		NA	T	FUS	myxofibrosarcoma								3	23					0	0	0.009096	0	0
MTA2	9219	broad.mit.edu	37	11	62363320	62363320	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:62363320C>G	uc001ntq.1	-	13	1539	c.1158G>C	c.(1156-1158)ATG>ATC	p.M386I	MTA2_uc010rlx.1_Missense_Mutation_p.M213I	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	386	GATA-type; atypical.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGCGGCACTGCATGTTAGGTG	0.582			NA											11	48					0	0	0.010729	0	0
SNX32	254122	broad.mit.edu	37	11	65617697	65617697	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:65617697C>G	uc001ofr.2	+	4	456	c.329C>G	c.(328-330)TCT>TGT	p.S110C	SNX32_uc009yqt.2_3'UTR|SNX32_uc010rop.1_Missense_Mutation_p.L150V	NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B	110	PX.				cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		GGGGACAGCTCTGTCACTCGG	0.597			NA											6	47					0	0	0.001984	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74915502	74915502	+	Silent	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:74915502T>A	uc001owb.2	+	14	2394	c.2007T>A	c.(2005-2007)GTT>GTA	p.V669V	SLCO2B1_uc010rrr.1_Silent_p.V525V|SLCO2B1_uc010rrs.1_Silent_p.V553V|SLCO2B1_uc001owc.2_Silent_p.V442V|SLCO2B1_uc001owd.2_Silent_p.V647V	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	669	Helical; Name=12; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	TCGCCTTAGTTTTGGCTGTCC	0.547			NA											12	78					0	0	0.001368	0	0
RAB38	23682	broad.mit.edu	37	11	87847182	87847182	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:87847182T>C	uc001pcj.1	-	3	657	c.610A>G	c.(610-612)AGC>GGC	p.S204G		NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	204					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCAGAGCAGCTGGCAACCTTG	0.478			NA											20	100					0	0	0.007413	0	0
FOLH1B	219595	broad.mit.edu	37	11	89405072	89405072	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:89405072G>T	uc001pda.2	+	5	725	c.199G>T	c.(199-201)GGA>TGA	p.G67*		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	67					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TGTCATTCTGGGAGGTCACCG	0.413			NA											20	110					5.26018e-13	7.24774e-13	0.012319	1	0
FOLH1B	219595	broad.mit.edu	37	11	89405092	89405092	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:89405092G>C	uc001pda.2	+	5	745	c.219G>C	c.(217-219)TGG>TGC	p.W73C		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	73					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGGACTCATGGGTGTTTGGTG	0.413			NA											22	123					0	0	0.00278	0	0
SLC36A4	120103	broad.mit.edu	37	11	92899090	92899090	+	Silent	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:92899090T>A	uc001pdn.2	-	8	958	c.861A>T	c.(859-861)ATA>ATT	p.I287I	SLC36A4_uc001pdm.2_Silent_p.I152I	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	287	Helical; (Potential).				L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTACCACTCCTATGCCTTCAA	0.323			NA											6	24					0	0	0.001168	0	0
PIWIL4	143689	broad.mit.edu	37	11	94316682	94316682	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:94316682G>A	uc001pfa.2	+	5	793	c.582G>A	c.(580-582)GAG>GAA	p.E194E	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	194					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TGAAGAGGGAGCTGCCATCAA	0.418			NA											16	228					0	0	0.00499	0	0
GRIA4	2893	broad.mit.edu	37	11	105483079	105483079	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:105483079C>T	uc001pix.2	+	3	611	c.165C>T	c.(163-165)CCC>CCT	p.P55P	GRIA4_uc001piu.1_Silent_p.P55P|GRIA4_uc001piw.2_Silent_p.P55P|GRIA4_uc001piv.2_Silent_p.P55P|GRIA4_uc009yxk.1_Silent_p.P55P|GRIA4_uc001pit.2_Silent_p.P55P	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	55	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ACACCAGCCCCAATGCGTCGG	0.408			NA											22	101					0	0	0.003954	0	0
TTC12	54970	broad.mit.edu	37	11	113230118	113230118	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:113230118G>A	uc001pnu.2	+	17	1585	c.1480G>A	c.(1480-1482)GAG>AAG	p.E494K	TTC12_uc001pnv.2_Missense_Mutation_p.E500K|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Missense_Mutation_p.E344K	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	494							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		CCTGTTCAGAGAGGTTATCTA	0.493			NA											18	131					0	0	0.008871	0	0
BUD13	84811	broad.mit.edu	37	11	116633907	116633907	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:116633907T>A	uc001ppn.2	-	4	432	c.398A>T	c.(397-399)CAT>CTT	p.H133L	BUD13_uc001ppo.2_Missense_Mutation_p.H133L|BUD13_uc009yzc.2_Missense_Mutation_p.H133L	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	133	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		TGGGGTACCATGACGGACCCT	0.537			NA											19	109					0	0	0.008871	0	0
UBE4A	9354	broad.mit.edu	37	11	118263480	118263480	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:118263480G>T	uc001psw.2	+	19	3073	c.2944G>T	c.(2944-2946)GAG>TAG	p.E982*	UBE4A_uc001psv.2_Nonsense_Mutation_p.E989*	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	982					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		ACAACAGGAAGAGGAAACCTA	0.473			NA											24	104					5.45024e-15	7.65931e-15	0.00333	1	0
MLL	4297	broad.mit.edu	37	11	118359361	118359361	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr11:118359361C>T	uc001pta.2	+	11	4388	c.4365C>T	c.(4363-4365)TTC>TTT	p.F1455F	MLL_uc001ptb.2_Silent_p.F1455F|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1455	PHD-type 1.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GTGAGCCCTTCCACAAGTTTT	0.418			NA	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								9	90					0	0	0.008291	0	0
TAS2R30	259293	broad.mit.edu	37	12	11286483	11286483	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:11286483T>A	uc009zhs.1	-	1	361	c.361A>T	c.(361-363)ATA>TTA	p.I121L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_001097643	NP_001091112			type 2 taste receptor member 30												0						CTCCTCTTTATGCGAAGAAAA	0.413			NA											19	110					0	0	0.008871	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715803	13715803	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:13715803G>A	uc001rbt.2	-	13	4548	c.4369C>T	c.(4369-4371)CCT>TCT	p.P1457S		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1457	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGTTGTTAGGCACACAGGGG	0.522			NA											10	123					0	0	0.008291	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906490	13906490	+	Silent	SNP	G	G	A	rs142203984		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:13906490G>A	uc001rbt.2	-	3	950	c.771C>T	c.(769-771)ATC>ATT	p.I257I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	257	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.I257I(1)		central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GACTGGGCACGATCCACGTGT	0.532			NA											5	45					0	0	0.00308	0	0
RECQL	5965	broad.mit.edu	37	12	21636334	21636334	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:21636334G>A	uc001rex.2	-	7	1024	c.676C>T	c.(676-678)CAG>TAG	p.Q226*	RECQL_uc001rey.2_Nonsense_Mutation_p.Q226*	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	226	Helicase ATP-binding.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TGTCCCCACTGACTACAGCAG	0.388			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					12	101					0	0	0.001855	0	0
NELL2	4753	broad.mit.edu	37	12	45170870	45170870	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:45170870C>G	uc001rog.2	-	7	1312	c.717G>C	c.(715-717)CAG>CAC	p.Q239H	NELL2_uc001rof.3_Missense_Mutation_p.Q238H|NELL2_uc001roh.2_Missense_Mutation_p.Q239H|NELL2_uc009zkd.2_Missense_Mutation_p.Q238H|NELL2_uc010skz.1_Missense_Mutation_p.Q289H|NELL2_uc010sla.1_Missense_Mutation_p.Q262H|NELL2_uc001roi.1_Missense_Mutation_p.Q239H|NELL2_uc010slb.1_Missense_Mutation_p.Q238H|NELL2_uc001roj.2_Missense_Mutation_p.Q239H	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	239	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		CCATGATTTTCTGCACAAGTC	0.393			NA											9	84					0	0	0.004482	0	0
ARID2	196528	broad.mit.edu	37	12	46233223	46233223	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:46233223T>A	uc001ros.1	+	11	1442	c.1442T>A	c.(1441-1443)ATT>AAT	p.I481N	ARID2_uc001ror.2_Missense_Mutation_p.I481N|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Missense_Mutation_p.I108N|ARID2_uc001rot.1_Missense_Mutation_p.I127N	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	481					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTATCTGAAATTAGGCCACAA	0.423			NA											8	139					0	0	0.006214	0	0
FAM186B	84070	broad.mit.edu	37	12	49997097	49997097	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:49997097C>T	uc001ruo.2	-	3	549	c.376G>A	c.(376-378)GCT>ACT	p.A126T	FAM186B_uc010smk.1_Missense_Mutation_p.A36T	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	126						protein complex				ovary(1)	1						TCGTCCAGAGCTGCTGCTTCC	0.547			NA											7	53					0	0	0.00308	0	0
FAM186B	84070	broad.mit.edu	37	12	49997107	49997107	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:49997107C>T	uc001ruo.2	-	3	539	c.366G>A	c.(364-366)GAG>GAA	p.E122E	FAM186B_uc010smk.1_Silent_p.E32E	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	122						protein complex				ovary(1)	1						CTGCTGCTTCCTCTTCACTCT	0.552			NA											7	45					0	0	0.00308	0	0
POU6F1	5463	broad.mit.edu	37	12	51584291	51584291	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:51584291C>T	uc001rxy.2	-	5	837	c.645G>A	c.(643-645)CGG>CGA	p.R215R	POU6F1_uc001rxz.2_Silent_p.R215R|POU6F1_uc001rya.2_Silent_p.R215R	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	215					brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTCCTGGTTCCGCAGTTCAG	0.572			NA											20	215					0	0	0.012319	0	0
DAZAP2	9802	broad.mit.edu	37	12	51636127	51636127	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:51636127G>C	uc010snd.1	+	4	499	c.315G>C	c.(313-315)TGG>TGC	p.W105C	DAZAP2_uc001ryb.2_Missense_Mutation_p.G109A|DAZAP2_uc010snc.1_Missense_Mutation_p.G49A|DAZAP2_uc010sne.1_Missense_Mutation_p.G99A|DAZAP2_uc010snf.1_Intron	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	Error:Variant_position_missing_in_Q15038_after_alignment							WW domain binding				0						CCACCTCCTGGATGCCCTCCC	0.542			NA											33	462					0	0	0.002836	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54911422	54911422	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:54911422G>A	uc001sgc.3	+	12	1280	c.1201G>A	c.(1201-1203)GAC>AAC	p.D401N	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.D351N	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	401					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GGACTATGCTGACTCGTTAGT	0.493			NA											4	43					0	0	0.009096	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57868455	57868455	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:57868455G>T	uc001sod.2	-	17	2146	c.1953C>A	c.(1951-1953)AGC>AGA	p.S651R	ARHGAP9_uc001sny.2_RNA|ARHGAP9_uc001snz.2_Missense_Mutation_p.S377R|ARHGAP9_uc001soa.2_Missense_Mutation_p.S250R|ARHGAP9_uc001sob.2_Missense_Mutation_p.S561R|ARHGAP9_uc001soc.2_Missense_Mutation_p.S561R|ARHGAP9_uc001soe.1_Missense_Mutation_p.S640R	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	580	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			CCAAGTTCCCGCTCACCCGAT	0.512			NA											9	126					0.000442599	0.000486284	0.006214	1	0
IL22	50616	broad.mit.edu	37	12	68647143	68647143	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:68647143T>A	uc001sty.1	-	1	139	c.86A>T	c.(85-87)CAG>CTG	p.Q29L	IL22_uc010stb.1_Missense_Mutation_p.Q29L	NM_020525	NP_065386	Q9GZX6	IL22_HUMAN	interleukin 22 precursor	29					acute-phase response	extracellular space	cytokine activity|interleukin-22 receptor binding				0		Myeloproliferative disorder(1001;0.0255)	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)		TGCTCCTCCCTGTACCAAGAG	0.567			NA											8	51					0	0	0.004482	0	0
SSH1	54434	broad.mit.edu	37	12	109186349	109186349	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:109186349C>G	uc001tnm.2	-	14	1693	c.1606G>C	c.(1606-1608)GAG>CAG	p.E536Q	SSH1_uc001tnl.2_Missense_Mutation_p.E224Q|SSH1_uc010sxg.1_Missense_Mutation_p.E547Q|SSH1_uc001tnn.3_Missense_Mutation_p.E536Q	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	536					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						GCCTCCCTCTCCGGATCCTCC	0.627			NA											6	91					0	0	0.001984	0	0
C12orf34	84915	broad.mit.edu	37	12	110206380	110206380	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:110206380G>C	uc001tpd.1	+	3	1205	c.646G>C	c.(646-648)GCA>CCA	p.A216P	MGC14436_uc010sxs.1_Intron|MGC14436_uc001tpe.2_Intron|C12orf34_uc001tpf.1_Missense_Mutation_p.A216P	NM_032829	NP_116218	Q5U5X8	CL034_HUMAN	hypothetical protein LOC84915	216	Pro-rich.									ovary(1)	1						CCCGGGCGCCGCACCCCCTGC	0.721			NA											3	22					0	0	0.009096	0	0
CUX2	23316	broad.mit.edu	37	12	111758260	111758260	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:111758260C>G	uc001tsa.1	+	17	2600	c.2447C>G	c.(2446-2448)TCT>TGT	p.S816C		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	816						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TCTGGCTACTCTGGCCAGCCC	0.756			NA											6	24					0	0	0.001168	0	0
CUX2	23316	broad.mit.edu	37	12	111776136	111776136	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:111776136C>A	uc001tsa.1	+	20	3396	c.3243C>A	c.(3241-3243)TCC>TCA	p.S1081S		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1081	CUT 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CACAGGGCTCCGTGTCTGACC	0.622			NA											6	62					0.00198382	0.00211908	0.001984	1	0
NAA25	80018	broad.mit.edu	37	12	112528570	112528570	+	Silent	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:112528570T>A	uc001ttm.2	-	3	263	c.243A>T	c.(241-243)TCA>TCT	p.S81S	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Silent_p.S53S|NAA25_uc009zwa.1_Silent_p.S81S	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	81	TPR 3.					cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						GTGCCTGCAGTGAGTTGTCAT	0.428			NA											11	125					0	0	0.001368	0	0
RBM19	9904	broad.mit.edu	37	12	114377779	114377779	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:114377779G>C	uc009zwi.2	-	15	2068	c.1924C>G	c.(1924-1926)CTG>GTG	p.L642V	RBM19_uc001tvn.3_Missense_Mutation_p.L642V|RBM19_uc001tvm.2_Missense_Mutation_p.L642V	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	642	RRM 4.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GAATAGGCCAGATGCCTGAAG	0.612			NA											7	52					0	0	0.004482	0	0
CLIP1	6249	broad.mit.edu	37	12	122862308	122862308	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr12:122862308G>A	uc001ucg.1	-	2	391	c.285C>T	c.(283-285)CCC>CCT	p.P95P	CLIP1_uc001uch.1_Silent_p.P95P|CLIP1_uc001uci.1_Silent_p.P95P|CLIP1_uc010tae.1_Silent_p.P95P	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	95	CAP-Gly 1.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TCTTGCCTATGGGTTCATCTA	0.463			NA											10	141					0	0	0.008291	0	0
POSTN	10631	broad.mit.edu	37	13	38145512	38145512	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr13:38145512G>T	uc001uwo.3	-	18	2291	c.2173C>A	c.(2173-2175)CAT>AAT	p.H725N	POSTN_uc010tet.1_Missense_Mutation_p.H226N|POSTN_uc001uwp.3_Intron|POSTN_uc001uwr.2_Missense_Mutation_p.H698N|POSTN_uc001uwq.2_Intron|POSTN_uc010teu.1_Missense_Mutation_p.H698N|POSTN_uc010tev.1_Intron|POSTN_uc010tew.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	725					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GCACCTCCATGGATCACTTCA	0.378			NA											17	60					1.02788e-11	1.39357e-11	0.00499	1	0
LOC220429	220429	broad.mit.edu	37	13	50466975	50466975	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr13:50466975G>C	uc001vdk.2	+	1	2431	c.2249G>C	c.(2248-2250)AGA>ACA	p.R750T		NR_003268				Homo sapiens CTAGE family, member 5 pseudogene, mRNA (cDNA clone IMAGE:5270026).												0						TTTGCAATGAGAAATGTCTGT	0.517			NA											4	57					0	0	0.009096	0	0
ATP7B	540	broad.mit.edu	37	13	52539113	52539113	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr13:52539113C>A	uc001vfw.2	-	5	1921	c.1764G>T	c.(1762-1764)AGG>AGT	p.R588S	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.R588S|ATP7B_uc001vfy.2_Missense_Mutation_p.R477S|ATP7B_uc010tgt.1_Missense_Mutation_p.R588S|ATP7B_uc010tgu.1_Missense_Mutation_p.R588S|ATP7B_uc010tgv.1_Missense_Mutation_p.R588S|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	588	HMA 6.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TGCCATTTGTCCTCGTGAGTT	0.498			NA							Wilson_disease				20	69					1.33834e-09	1.7636e-09	0.007413	1	0
PCDH9	5101	broad.mit.edu	37	13	67802360	67802360	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr13:67802360C>A	uc001vik.2	-	2	905	c.213G>T	c.(211-213)GGG>GGT	p.G71G	PCDH9_uc001vil.2_Silent_p.G71G|PCDH9_uc010thl.1_Silent_p.G71G|PCDH9_uc001vin.3_Silent_p.G71G	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	71	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		AAGGGGCATCCCCAGCTTTAG	0.488			NA											11	53					4.68919e-08	5.9387e-08	0.008291	1	0
COL4A2	1284	broad.mit.edu	37	13	111118389	111118389	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr13:111118389G>A	uc001vqx.2	+	26	2307	c.2018G>A	c.(2017-2019)AGA>AAA	p.R673K		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	673	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGAGGTGACAGACAGGAGGCC	0.498			NA											7	53					0	0	0.004482	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113176788	113176788	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr13:113176788G>A	uc001vse.1	-	14	1778	c.1591C>T	c.(1591-1593)CAG>TAG	p.Q531*	TUBGCP3_uc010tjq.1_Nonsense_Mutation_p.Q521*|TUBGCP3_uc001vsf.2_Nonsense_Mutation_p.Q531*	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	531					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					ATCTTCCCCTGAAATGCATTT	0.423			NA											7	74					0	0	0.00308	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215671	20215671	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:20215671T>A	uc010tkt.1	+	1	85	c.85T>A	c.(85-87)TTA>ATA	p.L29I		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTTCTCTTCTTACTATTTTT	0.383			NA											30	275					0	0	0.012213	0	0
SLC7A7	9056	broad.mit.edu	37	14	23243287	23243287	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:23243287G>A	uc001wgr.3	-	9	1422	c.1284C>T	c.(1282-1284)ACC>ACT	p.T428T	SLC7A7_uc001wgs.3_Silent_p.T428T|SLC7A7_uc001wgt.3_Silent_p.T428T|SLC7A7_uc001wgu.3_Silent_p.T428T|SLC7A7_uc001wgv.3_Silent_p.T428T	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	428	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		CCAGGAAGATGGTGCAGAGGC	0.478			NA											11	50					0	0	0.008291	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878023	24878023	+	Silent	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:24878023G>T	uc001wpf.3	+	4	1341	c.1023G>T	c.(1021-1023)CTG>CTT	p.L341L		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	341					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TATCAGCCCTGGGTGTGTGCC	0.582			NA											6	31					2.0095e-06	2.38769e-06	0.001984	1	0
LRFN5	145581	broad.mit.edu	37	14	42360646	42360646	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:42360646G>T	uc001wvm.2	+	4	2777	c.1579G>T	c.(1579-1581)GGC>TGC	p.G527C	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	527	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTTTTTGGGAGGCACCATGAT	0.428			NA								HNSCC(30;0.082)			10	218					2.68362e-12	3.67369e-12	0.001368	1	0
FANCM	57697	broad.mit.edu	37	14	45644916	45644916	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:45644916C>T	uc001wwd.3	+	14	3058	c.2959C>T	c.(2959-2961)CTA>TTA	p.L987L	FANCM_uc010anf.2_Silent_p.L961L|FANCM_uc001wwe.3_Silent_p.L523L|FANCM_uc010ang.2_Silent_p.L201L	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	987					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						AAAAGAGGTACTAGCTAATGT	0.348			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				9	85					0	0	0.008291	0	0
KTN1	3895	broad.mit.edu	37	14	56085908	56085908	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:56085908G>A	uc001xcb.2	+	6	1143	c.841G>A	c.(841-843)GAA>AAA	p.E281K	KTN1_uc001xce.2_Missense_Mutation_p.E281K|KTN1_uc001xcc.2_Missense_Mutation_p.E281K|KTN1_uc001xcd.2_Missense_Mutation_p.E281K|KTN1_uc010trb.1_Missense_Mutation_p.E281K|KTN1_uc001xcf.1_Missense_Mutation_p.E281K	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	281	Lumenal (Potential).				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						AGAAAATGCTGAAGTGAAGTT	0.338			NA	T	RET	papillary thryoid								12	70					0	0	0.010729	0	0
PELI2	57161	broad.mit.edu	37	14	56746482	56746482	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:56746482C>T	uc001xch.2	+	3	582	c.296C>T	c.(295-297)ACG>ATG	p.T99M		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	99					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						GATAAGGATACGGATATGTTT	0.333			NA											15	126					0	0	0.004007	0	0
EXD2	55218	broad.mit.edu	37	14	69695691	69695691	+	Silent	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:69695691T>A	uc001xkt.2	+	5	776	c.117T>A	c.(115-117)GTT>GTA	p.V39V	EXD2_uc001xku.2_5'UTR|EXD2_uc001xkv.2_Silent_p.V164V|EXD2_uc001xkw.2_Silent_p.V39V|EXD2_uc001xkx.2_RNA|EXD2_uc010aqt.2_Silent_p.V164V|EXD2_uc010tte.1_Silent_p.V164V|EXD2_uc001xky.2_Silent_p.V39V	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	39	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						TTTTGAAAGTTGGAGTGGGAT	0.512			NA											10	74					0	0	0.006214	0	0
EIF2B2	8892	broad.mit.edu	37	14	75469779	75469779	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:75469779G>A	uc001xrc.1	+	1	168	c.86G>A	c.(85-87)CGC>CAC	p.R29H		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	29					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		GGTGGGCCGCGCAGCTCCGAG	0.662			NA											7	51					0	0	0.001984	0	0
EIF2B2	8892	broad.mit.edu	37	14	75474434	75474434	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:75474434G>A	uc001xrc.1	+	7	923	c.841G>A	c.(841-843)GAA>AAA	p.E281K		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	281					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		GTTCCCCAATGAAGAAGACTC	0.194			NA											6	66					0	0	0.00308	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416366	105416366	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr14:105416366C>T	uc010axc.1	-	7	5542	c.5422G>A	c.(5422-5424)GAC>AAC	p.D1808N	AHNAK2_uc001ypx.2_Missense_Mutation_p.D1708N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1808						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGGGACAGGTCACCCTCCAGC	0.627			NA											18	228					0	0	0.007413	0	0
C15orf2	23742	broad.mit.edu	37	15	24923219	24923219	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:24923219C>A	uc001ywo.2	+	1	2679	c.2205C>A	c.(2203-2205)CCC>CCA	p.P735P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	735					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		ACACACAACCCAGCGGCAACA	0.552			NA											15	109					7.93312e-07	9.58774e-07	0.00245	1	0
OCA2	4948	broad.mit.edu	37	15	28211876	28211876	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:28211876C>A	uc001zbh.3	-	15	1706	c.1596G>T	c.(1594-1596)TGG>TGT	p.W532C	OCA2_uc010ayv.2_Missense_Mutation_p.W508C	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	532	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GCTTTCTGTTCCAGTAAAGGA	0.443			NA							Oculocutaneous_Albinism				18	65					3.51602e-12	4.79766e-12	0.008871	1	0
TRPM1	4308	broad.mit.edu	37	15	31324995	31324995	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:31324995C>A	uc001zfm.2	-	21	2911	c.2783G>T	c.(2782-2784)CGG>CTG	p.R928L	TRPM1_uc010azy.2_Missense_Mutation_p.R835L|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	928	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GTAGATCACCCGGCCATAGCC	0.483			NA											13	94					0.00010058	0.000112852	0.001368	1	0
MEIS2	4212	broad.mit.edu	37	15	37242563	37242563	+	Silent	SNP	C	C	G	rs140793410		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:37242563C>G	uc001zjr.2	-	9	1976	c.939G>C	c.(937-939)GCG>GCC	p.A313A	MEIS2_uc001zjl.2_Silent_p.A300A|MEIS2_uc010ucj.1_Silent_p.A300A|MEIS2_uc001zjm.2_Silent_p.A225A|MEIS2_uc001zjn.2_Silent_p.A167A|MEIS2_uc001zjo.2_Silent_p.A313A|MEIS2_uc001zjp.2_Silent_p.A313A|MEIS2_uc001zjs.2_Silent_p.A313A|MEIS2_uc001zju.2_Silent_p.A300A|MEIS2_uc001zjt.2_Silent_p.A313A	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	313	Homeobox; TALE-type.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		CTGTGTCTTGCGCTAACTGTT	0.373			NA											11	199					0	0	0.003163	0	0
TRIM69	140691	broad.mit.edu	37	15	45028843	45028843	+	Translation_Start_Site	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:45028843C>A	uc001zuf.2	+	2	836	c.-59C>A	c.(-61--57)TCCTG>TCATG		TRIM69_uc001zui.1_Translation_Start_Site|TRIM69_uc010bdy.1_Translation_Start_Site|TRIM69_uc001zug.1_Translation_Start_Site|TRIM69_uc001zuh.1_Translation_Start_Site	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a						apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		TGCAGCCATCCTGGGCCTGCT	0.512	Pancreas(84;519 1450 1802 20427 34706)		NA											8	27					1.06961e-07	1.35059e-07	0.00308	1	0
SEMA6D	80031	broad.mit.edu	37	15	48062801	48062801	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:48062801G>T	uc010bek.2	+	19	2401	c.2041G>T	c.(2041-2043)GTG>TTG	p.V681L	SEMA6D_uc001zvw.2_Missense_Mutation_p.V619L|SEMA6D_uc001zvy.2_Missense_Mutation_p.V681L|SEMA6D_uc001zvz.2_Missense_Mutation_p.V625L|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.V619L|SEMA6D_uc001zwc.2_Missense_Mutation_p.V606L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	681	Helical; (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CATTGCAGGTGTGGCAGTATA	0.473			NA											15	83					4.75885e-15	6.70998e-15	0.00499	1	0
ATP8B4	79895	broad.mit.edu	37	15	50271905	50271905	+	Nonsense_Mutation	SNP	C	C	A	rs140655722		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:50271905C>A	uc001zxu.2	-	12	1085	c.943G>T	c.(943-945)GGA>TGA	p.G315*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.G188*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.G188*|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	315	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTCTTCTCTCCTTCATTCCAA	0.378			NA											31	144					9.78485e-24	1.41746e-23	0.002836	1	0
MNS1	55329	broad.mit.edu	37	15	56736859	56736859	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:56736859C>T	uc002adr.2	-	5	634	c.469G>A	c.(469-471)GAA>AAA	p.E157K	MNS1_uc010bfo.2_Missense_Mutation_p.E25K|TEX9_uc002adp.2_Intron|TEX9_uc010ugl.1_Intron	NM_018365	NP_060835	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	157	Potential.|Glu-rich.				meiosis					ovary(1)	1				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		TTGGCTATTTCAGCATCACGT	0.313			NA											16	170					0	0	0.007413	0	0
ZNF609	23060	broad.mit.edu	37	15	64967177	64967177	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:64967177C>A	uc002ann.2	+	4	2124	c.2124C>A	c.(2122-2124)CCC>CCA	p.P708P		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	708						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						AGCCCAAGCCCACTGTTATGG	0.517			NA											12	162					7.93312e-07	9.58774e-07	0.00245	1	0
ZNF609	23060	broad.mit.edu	37	15	64967739	64967739	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:64967739G>C	uc002ann.2	+	4	2686	c.2686G>C	c.(2686-2688)GAG>CAG	p.E896Q		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	896						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCAAGGCTTTGAGAGTTACTA	0.507			NA											9	102					0	0	0.004482	0	0
IGDCC4	57722	broad.mit.edu	37	15	65684634	65684634	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:65684634G>A	uc002aou.1	-	11	2170	c.1960C>T	c.(1960-1962)CAC>TAC	p.H654Y	IGDCC4_uc002aot.1_Missense_Mutation_p.H242Y	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	654	Extracellular (Potential).|Fibronectin type-III 3.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						TGGGTGGGGTGAGGGGGTGGC	0.637			NA											7	34					0	0	0.001984	0	0
ACAN	176	broad.mit.edu	37	15	89402294	89402294	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:89402294G>C	uc010upo.1	+	12	6852	c.6478G>C	c.(6478-6480)GAG>CAG	p.E2160Q	ACAN_uc010upp.1_Missense_Mutation_p.E2160Q|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2160					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCAAGAAGGCGAGGCGTCCGC	0.577			NA											6	58					0	0	0.001168	0	0
RGS11	8786	broad.mit.edu	37	16	321456	321456	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:321456C>T	uc002cgj.1	-	11	694	c.691G>A	c.(691-693)GAG>AAG	p.E231K	RGS11_uc002cgi.1_Missense_Mutation_p.E210K|RGS11_uc010bqs.1_Missense_Mutation_p.E220K|RGS11_uc002cgk.1_Missense_Mutation_p.E47K	NM_183337	NP_899180	O94810	RGS11_HUMAN	regulator of G-protein signalling 11 isoform 1	231	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			lung(1)|pancreas(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CTGAAGTACTCGATCTAGGAT	0.622			NA											5	34					0	0	0.000602	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270419	1270419	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:1270419G>A	uc002cks.2	+	35	6735	c.6487G>A	c.(6487-6489)GGG>AGG	p.G2163R	CACNA1H_uc002ckt.2_Missense_Mutation_p.G2157R|CACNA1H_uc002cku.2_Missense_Mutation_p.G858R|CACNA1H_uc010brj.2_Missense_Mutation_p.G874R|CACNA1H_uc002ckv.2_Missense_Mutation_p.G852R	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	2163	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCTGGGCAGCGGGGAGCCTGG	0.716			NA											5	25					0	0	0.000602	0	0
SPSB3	90864	broad.mit.edu	37	16	1828177	1828177	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:1828177G>A	uc002cmr.2	-	3	483	c.450C>T	c.(448-450)TTC>TTT	p.F150F	SPSB3_uc002cms.2_Silent_p.F22F|SPSB3_uc002cmt.2_Silent_p.F22F|SPSB3_uc002cmu.2_Silent_p.F150F|SPSB3_uc002cmv.2_Silent_p.F22F|SPSB3_uc010uvm.1_3'UTR	NM_080861	NP_543137	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box	150	B30.2/SPRY.				intracellular signal transduction						0						TGATCTCCCAGAAGTGCTGGC	0.637			NA											4	19					0	0	0.009096	0	0
PKD1	5310	broad.mit.edu	37	16	2153583	2153583	+	Silent	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:2153583G>T	uc002cos.1	-	23	8684	c.8475C>A	c.(8473-8475)CTC>CTA	p.L2825L	PKD1_uc002cot.1_Silent_p.L2825L|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2825	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCAGAAAGATGAGCTGCACCA	0.622			NA											5	82					4.096e-09	5.34756e-09	0.001168	1	0
SRRM2	23524	broad.mit.edu	37	16	2812607	2812607	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:2812607G>T	uc002crk.2	+	11	2627	c.2078G>T	c.(2077-2079)CGG>CTG	p.R693L	SRRM2_uc002crj.1_Missense_Mutation_p.R597L|SRRM2_uc002crl.1_Missense_Mutation_p.R693L|SRRM2_uc010bsu.1_Missense_Mutation_p.R597L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	693	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GGGAGGTCTCGGTCTAGGACA	0.567			NA											14	70					7.93312e-07	9.58774e-07	0.00245	1	0
ZNF213	7760	broad.mit.edu	37	16	3190770	3190770	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:3190770G>T	uc010uws.1	+	6	1249	c.802G>T	c.(802-804)GTG>TTG	p.V268L	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Missense_Mutation_p.V268L|ZNF213_uc010uwt.1_3'UTR	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	268	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGGCAGCGACGTGACTGTGTC	0.697			NA											6	48					2.0095e-06	2.38769e-06	0.001984	1	0
USP7	7874	broad.mit.edu	37	16	8998387	8998387	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:8998387G>T	uc002czl.2	-	15	1808	c.1609C>A	c.(1609-1611)CCT>ACT	p.P537T	USP7_uc010uyk.1_Missense_Mutation_p.P438T|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.P438T|USP7_uc002czk.2_Missense_Mutation_p.P521T|USP7_uc010uyl.1_Intron	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	537					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						AACTGCTGAGGAATATCATGG	0.522			NA											5	77					0.00198382	0.00211908	0.001984	1	0
GPRC5B	51704	broad.mit.edu	37	16	19873227	19873227	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:19873227G>C	uc002dgt.2	-	3	1207	c.1099C>G	c.(1099-1101)CCC>GCC	p.P367A	GPRC5B_uc010vav.1_Missense_Mutation_p.P393A	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	367	Cytoplasmic (Potential).									lung(1)|breast(1)|skin(1)	3						GGAGCGCTGGGTCTTTTCCCC	0.547			NA											5	62					0	0	0.000602	0	0
SLC5A11	115584	broad.mit.edu	37	16	24902295	24902295	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:24902295C>A	uc002dmu.2	+	9	1002	c.770C>A	c.(769-771)GCC>GAC	p.A257D	SLC5A11_uc002dms.2_Missense_Mutation_p.A193D|SLC5A11_uc010vcd.1_Missense_Mutation_p.A222D|SLC5A11_uc002dmt.2_Intron|SLC5A11_uc010vce.1_Missense_Mutation_p.A187D|SLC5A11_uc010bxt.2_Missense_Mutation_p.A193D	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	257	Extracellular (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		CGGGAAGATGCCTTCCATATT	0.587			NA											47	186					4.01344e-20	5.77444e-20	0.00361	1	0
PHKB	5257	broad.mit.edu	37	16	47623005	47623005	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:47623005G>A	uc002eev.3	+	10	1112	c.1060G>A	c.(1060-1062)GAA>AAA	p.E354K	PHKB_uc002eeu.3_Missense_Mutation_p.E347K	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	354					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				CAAGCCAGCTGAAATTAAGGT	0.219			NA											4	61					0	0	0.009096	0	0
ABCC11	85320	broad.mit.edu	37	16	48261806	48261806	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:48261806C>T	uc002eff.1	-	3	656	c.306G>A	c.(304-306)CCG>CCA	p.P102P	ABCC11_uc002efg.1_Silent_p.P102P|ABCC11_uc002efh.1_Silent_p.P102P|ABCC11_uc010vgl.1_Silent_p.P102P	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	102	Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGATCATGAGCGGGGTGAGCC	0.537			NA							Cerumen_Type				13	99					0	0	0.001368	0	0
SLC12A3	6559	broad.mit.edu	37	16	56920945	56920945	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:56920945G>T	uc010ccm.2	+	17	2147	c.2118G>T	c.(2116-2118)AAG>AAT	p.K706N	SLC12A3_uc002ekd.3_Missense_Mutation_p.K706N|SLC12A3_uc010ccn.2_Missense_Mutation_p.K705N	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	706	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GGAAGATCAAGGCCTTCTACT	0.612			NA											5	41					5.9392e-07	7.28198e-07	0.001168	1	0
CNOT1	23019	broad.mit.edu	37	16	58568128	58568128	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:58568128C>A	uc002env.2	-	40	6111	c.5818G>T	c.(5818-5820)GTT>TTT	p.V1940F	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.V1935F|CNOT1_uc002ent.2_5'Flank|CNOT1_uc010vik.1_Missense_Mutation_p.V897F	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1940					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATGAGTCGAACAAAGGCATCC	0.493			NA											14	36					7.93312e-07	9.58774e-07	0.00245	1	0
NFATC3	4775	broad.mit.edu	37	16	68225105	68225105	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:68225105G>T	uc002evo.1	+	9	2743	c.2533G>T	c.(2533-2535)GGC>TGC	p.G845C	NFATC3_uc010vkl.1_Missense_Mutation_p.G366C|NFATC3_uc010vkm.1_Missense_Mutation_p.G366C|NFATC3_uc010vkn.1_Missense_Mutation_p.G366C|NFATC3_uc010vko.1_Missense_Mutation_p.G366C|NFATC3_uc010vkp.1_Missense_Mutation_p.G366C|NFATC3_uc010vkq.1_Missense_Mutation_p.G366C|NFATC3_uc002evl.2_Missense_Mutation_p.G366C|NFATC3_uc002evk.2_Missense_Mutation_p.G845C|NFATC3_uc002evm.1_Missense_Mutation_p.G845C|NFATC3_uc002evn.1_Missense_Mutation_p.G845C|NFATC3_uc010vkr.1_Missense_Mutation_p.G366C|NFATC3_uc010vks.1_Missense_Mutation_p.G366C|NFATC3_uc010vkt.1_Missense_Mutation_p.G366C|NFATC3_uc010vku.1_Missense_Mutation_p.G366C|NFATC3_uc010vkv.1_Missense_Mutation_p.G366C|NFATC3_uc010vkw.1_Missense_Mutation_p.G366C|NFATC3_uc010vkx.1_Missense_Mutation_p.G366C|NFATC3_uc010vky.1_Missense_Mutation_p.G366C|NFATC3_uc010vkz.1_Missense_Mutation_p.G366C|NFATC3_uc010vla.1_Missense_Mutation_p.G366C|NFATC3_uc010vlb.1_Missense_Mutation_p.G366C|NFATC3_uc010vlc.1_Missense_Mutation_p.G366C	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	845					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		AGTGAATCTTGGCTGTCAACC	0.423			NA											39	178					9.62906e-15	1.34871e-14	0.00623	1	0
FTSJD1	55783	broad.mit.edu	37	16	71319478	71319478	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:71319478A>G	uc010cga.2	-	3	752	c.346T>C	c.(346-348)TGT>CGT	p.C116R	FTSJD1_uc002ezy.3_Missense_Mutation_p.C116R|FTSJD1_uc002ezz.3_Missense_Mutation_p.C116R	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	116						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						TGGAACTTACACCATGCTTGA	0.413			NA											20	75					0	0	0.007413	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76513396	76513396	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:76513396G>T	uc002feu.1	+	14	2228	c.1843G>T	c.(1843-1845)GGT>TGT	p.G615C	CNTNAP4_uc002fev.1_Missense_Mutation_p.G479C|CNTNAP4_uc010chb.1_Missense_Mutation_p.G542C|CNTNAP4_uc002fex.1_Missense_Mutation_p.G618C|CNTNAP4_uc002few.2_Missense_Mutation_p.G590C	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	615	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						AGATGGAAGTGGTCCCCTGGA	0.338			NA											25	90					4.59853e-10	6.11691e-10	0.005443	1	0
CDK10	8558	broad.mit.edu	37	16	89758876	89758876	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr16:89758876A>C	uc010cio.2	+	6	480	c.437A>C	c.(436-438)CAG>CCG	p.Q146P	CDK10_uc010cip.2_Missense_Mutation_p.Q75P|CDK10_uc010vpl.1_Missense_Mutation_p.Q140P|CDK10_uc002fob.2_Missense_Mutation_p.Q75P|CDK10_uc002fod.2_Missense_Mutation_p.Q75P|CDK10_uc002foe.2_Missense_Mutation_p.Q75P|CDK10_uc002fof.2_Missense_Mutation_p.Q75P|CDK10_uc002fog.3_Missense_Mutation_p.Q75P|CDK10_uc002foh.3_Missense_Mutation_p.Q75P|CDK10_uc002foi.2_5'Flank	NM_052988	NP_443714	Q15131	CDK10_HUMAN	cyclin-dependent kinase 10 isoform a	146	Protein kinase.				negative regulation of cell proliferation|traversing start control point of mitotic cell cycle		ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(1)	1		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0276)		ATCGTGCTGCAGGTGCTCCGG	0.597			NA											7	43					0	0	0.001984	0	0
SPNS3	201305	broad.mit.edu	37	17	4337360	4337360	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:4337360C>T	uc002fxt.2	+	1	142	c.98C>T	c.(97-99)ACG>ATG	p.T33M	SPNS3_uc002fxu.2_Translation_Start_Site	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	33					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						CCTCCCATCACGCCCACCTCC	0.657			NA											10	67					0	0	0.006214	0	0
WSCD1	23302	broad.mit.edu	37	17	6023892	6023892	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:6023892G>T	uc010cli.2	+	9	2018	c.1639G>T	c.(1639-1641)GAC>TAC	p.D547Y	WSCD1_uc002gcn.2_Missense_Mutation_p.D547Y|WSCD1_uc002gco.2_Missense_Mutation_p.D547Y|WSCD1_uc010clj.2_Missense_Mutation_p.D238Y	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	547						integral to membrane	sulfotransferase activity				0						GGAGATGAAAGACTTGATCAA	0.652			NA											10	41					2.17888e-05	2.51135e-05	0.006214	1	0
TMEM95	339168	broad.mit.edu	37	17	7258657	7258657	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:7258657G>T	uc002ggh.1	+	1	161	c.134G>T	c.(133-135)TGT>TTT	p.C45F	TMEM95_uc002ggf.1_Missense_Mutation_p.C45F|TMEM95_uc002ggg.1_Missense_Mutation_p.C45F	NM_198154	NP_937797	Q3KNT9	TMM95_HUMAN	transmembrane protein 95	45	Extracellular (Potential).					integral to membrane					0		Prostate(122;0.173)				CAGAAGGAATGTGGGGCCTCC	0.652			NA											7	33					1.26484e-09	1.67197e-09	0.00308	1	0
DNAH2	146754	broad.mit.edu	37	17	7701598	7701598	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:7701598A>T	uc002giu.1	+	53	8368	c.8354A>T	c.(8353-8355)CAG>CTG	p.Q2785L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2785	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACCACCTTCCAGATCGAGGTC	0.557			NA											4	35					0	0	0.009096	0	0
CHD3	1107	broad.mit.edu	37	17	7803213	7803213	+	Splice_Site	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:7803213G>A	uc002gje.2	+	16	2695	c.2545_splice	c.e16-1	p.R849_splice	CHD3_uc002gjd.2_Splice_Site_p.R908_splice|CHD3_uc002gjf.2_Splice_Site_p.R849_splice	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TATGTTGGCAGAGGGAGGCAC	0.537			NA											8	48					0	0	0.008291	0	0
ALOXE3	59344	broad.mit.edu	37	17	8018293	8018293	+	Silent	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:8018293A>G	uc010cnr.2	-	5	887	c.517T>C	c.(517-519)TTG>CTG	p.L173L	ALOXE3_uc002gka.2_Silent_p.L329L|ALOXE3_uc010vuo.1_Silent_p.L305L|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	173	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						GTCTTTGTCAAGGCAAATTTC	0.507			NA											19	191					0	0	0.012319	0	0
WDR16	146845	broad.mit.edu	37	17	9503470	9503470	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:9503470T>A	uc002gly.2	+	6	792	c.723T>A	c.(721-723)GAT>GAA	p.D241E	WDR16_uc002glz.2_Missense_Mutation_p.D173E|WDR16_uc010coc.2_Missense_Mutation_p.D251E	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	241						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TGCTGACAGATGTTGGGCCTG	0.448			NA											17	143					0	0	0.00499	0	0
KIAA0100	9703	broad.mit.edu	37	17	26961560	26961560	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:26961560G>A	uc002hbu.2	-	16	3144	c.3045C>T	c.(3043-3045)CTC>CTT	p.L1015L		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1015						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CATTGCACTTGAGCATTCGAC	0.498			NA											5	85					0	0	0.001168	0	0
EFCAB5	374786	broad.mit.edu	37	17	28405416	28405416	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:28405416G>T	uc002het.2	+	15	3113	c.2921G>T	c.(2920-2922)AGG>ATG	p.R974M	EFCAB5_uc010cse.2_Missense_Mutation_p.R729M|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	974							calcium ion binding			ovary(1)|skin(1)	2						GAGAGTCTGAGGAATTCTGCC	0.493			NA											23	80					1.1804e-14	1.64788e-14	0.003954	1	0
NF1	4763	broad.mit.edu	37	17	29559717	29559717	+	Splice_Site	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:29559717G>T	uc002hgg.2	+	26	3648	c.3315_splice	c.e26-1	p.K1105_splice	NF1_uc002hgh.2_Splice_Site_p.K1105_splice|NF1_uc010csn.1_Splice_Site_p.K965_splice|NF1_uc002hgi.1_Splice_Site_p.K138_splice	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTATTTCTCAGATACTTCACA	0.418			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			17	27					9.16793e-09	1.19324e-08	0.00499	1	0
IKZF3	22806	broad.mit.edu	37	17	37985700	37985700	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:37985700G>C	uc002hsu.2	-	3	165	c.103C>G	c.(103-105)CAT>GAT	p.H35D	IKZF3_uc002htd.2_Intron|IKZF3_uc010cwd.2_Missense_Mutation_p.H35D|IKZF3_uc002hsv.2_Intron|IKZF3_uc010cwe.2_Missense_Mutation_p.H35D|IKZF3_uc010cwf.2_Missense_Mutation_p.H35D|IKZF3_uc010cwg.2_Missense_Mutation_p.H35D|IKZF3_uc002hsw.2_Missense_Mutation_p.H35D|IKZF3_uc002hsx.2_Missense_Mutation_p.H35D|IKZF3_uc002hsy.2_Missense_Mutation_p.H35D|IKZF3_uc002hsz.2_Missense_Mutation_p.H35D|IKZF3_uc002hta.2_Missense_Mutation_p.H35D|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Missense_Mutation_p.H35D|IKZF3_uc002htc.2_5'UTR	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	35					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCCATTTCATGAGATTTGGTT	0.378			NA											11	124					0	0	0.001368	0	0
KIF2B	84643	broad.mit.edu	37	17	51901154	51901154	+	Missense_Mutation	SNP	G	G	T	rs142732898	byFrequency	TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:51901154G>T	uc002iua.2	+	1	916	c.760G>T	c.(760-762)GAC>TAC	p.D254Y	uc010wna.1_Intron	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	254	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GCAAAAGGTGGACCTCACTCG	0.547			NA											15	30					6.94344e-10	9.20714e-10	0.006122	1	0
RNF43	54894	broad.mit.edu	37	17	56434870	56434870	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:56434870G>A	uc002iwf.2	-	8	4223	c.2267C>T	c.(2266-2268)CCA>CTA	p.P756L	RNF43_uc010wnv.1_Missense_Mutation_p.P715L|RNF43_uc002iwh.3_Missense_Mutation_p.P756L|RNF43_uc002iwg.3_Missense_Mutation_p.P756L|RNF43_uc010dcw.2_Missense_Mutation_p.P629L	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	756	Pro-rich.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATAAGGGCATGGCCTGCCCTC	0.597			NA											7	55					0	0	0.001984	0	0
TBX4	9496	broad.mit.edu	37	17	59560581	59560581	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr17:59560581G>A	uc002izi.2	+	8	1387	c.1342G>A	c.(1342-1344)GCC>ACC	p.A448T	TBX4_uc010ddo.2_Missense_Mutation_p.A449T|TBX4_uc010woy.1_Missense_Mutation_p.A449T	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	448					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GCACTTCACCGCCACCACCAT	0.592			NA											6	62					0	0	0.00308	0	0
POTEC	388468	broad.mit.edu	37	18	14542921	14542921	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr18:14542921G>T	uc010dln.2	-	1	679	c.225C>A	c.(223-225)AGC>AGA	p.S75R	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	75										skin(3)	3						TGCTCGTGCCGCTCCCCCTGC	0.567			NA											10	218					1.58986e-06	1.91055e-06	0.008291	1	0
RIT2	6014	broad.mit.edu	37	18	40503602	40503602	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr18:40503602G>T	uc002lav.2	-	4	534	c.361C>A	c.(361-363)CGC>AGC	p.R121S	RIT2_uc010dnf.2_Missense_Mutation_p.R121S	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	121					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						TAGGTGTGGCGGACCTGAAAA	0.488			NA											27	263					2.41591e-17	3.44084e-17	0.004656	1	0
MIER2	54531	broad.mit.edu	37	19	334524	334524	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:334524C>A	uc002lok.1	-	3	128	c.119G>T	c.(118-120)GGA>GTA	p.G40V		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	40					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGATGGTCTCCAGAGCCCAT	0.607			NA											8	42					5.18039e-06	6.10392e-06	0.00308	1	0
MATK	4145	broad.mit.edu	37	19	3778291	3778291	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:3778291G>A	uc002lyt.2	-	14	1814	c.1414C>T	c.(1414-1416)CGC>TGC	p.R472C	MATK_uc002lyv.2_Missense_Mutation_p.R473C|MATK_uc002lyu.2_Missense_Mutation_p.R431C|MATK_uc010dtq.2_Missense_Mutation_p.R471C	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	472	Protein kinase.			ARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQE P -> PAGHPSANWPRSWPGSYAVQVPQPPSQGRTPTVHLA PKPGALTPPGGPWPQRTERVESAAWGH (in Ref. 1; AAA16703).	cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGTTTGCGGAAGGGTGGC	0.716			NA											9	33					0	0	0.008291	0	0
EMR1	2015	broad.mit.edu	37	19	6937293	6937293	+	Silent	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:6937293G>T	uc002mfw.2	+	19	2459	c.2421G>T	c.(2419-2421)CTG>CTT	p.L807L	EMR1_uc010dvc.2_Silent_p.L742L|EMR1_uc010dvb.2_Silent_p.L788L|EMR1_uc010xji.1_Silent_p.L666L|EMR1_uc010xjj.1_Silent_p.L630L	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	807	Helical; Name=6; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TCTTCATCCTGGGCTGCTCCT	0.552			NA											9	103					1.76689e-08	2.27172e-08	0.006214	1	0
MUC16	94025	broad.mit.edu	37	19	8976428	8976428	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:8976428C>G	uc002mkp.2	-	75	42604	c.42400G>C	c.(42400-42402)GAG>CAG	p.E14134Q	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.E934Q|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	14165	SEA 14.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCATCCTTCTCAGGCCTGGGG	0.617			NA											3	21					0	0	0.004672	0	0
OLFM2	93145	broad.mit.edu	37	19	9968409	9968409	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:9968409G>A	uc002mmp.2	-	3	370	c.342C>T	c.(340-342)CTC>CTT	p.L114L	OLFM2_uc002mmo.2_Silent_p.L36L	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	114						extracellular region				large_intestine(1)|skin(1)	2						TCTTGGCCGAGAGGGACCCAT	0.572			NA											10	35					0	0	0.010729	0	0
ZNF439	90594	broad.mit.edu	37	19	11978433	11978433	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:11978433G>C	uc002mss.2	+	3	677	c.549G>C	c.(547-549)AAG>AAC	p.K183N	ZNF439_uc002msr.2_Missense_Mutation_p.K47N	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACACTGGAAAGAAACCCTATG	0.403			NA											16	161					0	0	0.00499	0	0
CYP4F3	4051	broad.mit.edu	37	19	15769201	15769201	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:15769201C>T	uc002nbj.2	+	10	1293	c.1243C>T	c.(1243-1245)CCC>TCC	p.P415S	CYP4F3_uc010xok.1_Missense_Mutation_p.P415S|CYP4F3_uc010xol.1_Missense_Mutation_p.P415S|CYP4F3_uc010xom.1_Missense_Mutation_p.P266S|CYP4F3_uc002nbk.2_Missense_Mutation_p.P415S|CYP4F3_uc010xon.1_Missense_Mutation_p.P125S	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	415					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						CCGGGTCATCCCCAAAGGTGC	0.642			NA											5	44					0	0	0.001984	0	0
KIAA1683	80726	broad.mit.edu	37	19	18376264	18376264	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:18376264G>A	uc002nin.2	-	3	2302	c.2086C>T	c.(2086-2088)CTG>TTG	p.L696L	KIAA1683_uc010ebn.2_Silent_p.L696L|KIAA1683_uc010xqe.1_Silent_p.L650L	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	696						mitochondrion				ovary(2)	2						TCAGTGGGCAGATGTCCCTGA	0.617			NA											7	26					0	0	0.001984	0	0
ZNF493	284443	broad.mit.edu	37	19	21606273	21606273	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:21606273G>A	uc002npx.2	+	2	708	c.428G>A	c.(427-429)GGC>GAC	p.G143D	ZNF493_uc002npw.2_Missense_Mutation_p.G271D|ZNF493_uc002npy.2_Missense_Mutation_p.G143D	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	143	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAAGAATGTGGCACATCTTTC	0.343			NA											7	54					0	0	0.001984	0	0
ZNF676	163223	broad.mit.edu	37	19	22364130	22364130	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:22364130C>G	uc002nqs.1	-	3	707	c.389G>C	c.(388-390)AGA>ACA	p.R130T		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TATCTTATGTCTGTTTGAATT	0.313			NA											10	90					0	0	0.008291	0	0
ZNF91	7644	broad.mit.edu	37	19	23545212	23545212	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:23545212G>A	uc002nre.2	-	4	682	c.569C>T	c.(568-570)TCA>TTA	p.S190L	ZNF91_uc010xrj.1_Missense_Mutation_p.S158L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	190	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GATGCAAAATGACTTGACACA	0.303			NA											8	48					0	0	0.00308	0	0
PSG11	5680	broad.mit.edu	37	19	43523155	43523155	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:43523155C>A	uc002ovm.1	-	3	583	c.476G>T	c.(475-477)AGG>ATG	p.R159M	PSG11_uc002ouw.2_Missense_Mutation_p.R165M|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.R165M|PSG11_uc002ovn.1_Missense_Mutation_p.R165M|PSG11_uc002ovo.1_Missense_Mutation_p.R37M|PSG11_uc002ovp.1_Missense_Mutation_p.R37M	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	159	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CATGGCCTCCCTGGGGTTTAA	0.522			NA											35	205					6.19805e-25	9.00954e-25	0.005524	1	0
FOSB	2354	broad.mit.edu	37	19	45973886	45973886	+	Splice_Site	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:45973886G>A	uc002pbx.3	+	2	719	c.127_splice	c.e2-1	p.E43_splice	ERCC1_uc002pbu.1_Intron|FOSB_uc002pbw.2_Splice_Site_p.E43_splice|FOSB_uc010eke.2_Intron|FOSB_uc002pby.3_Splice_Site_p.E43_splice|FOSB_uc010eka.1_Intron|FOSB_uc010ekb.1_Splice_Site_p.E43_splice|FOSB_uc010ekc.1_Intron|FOSB_uc010ekf.2_Intron|FOSB_uc010ekd.1_Splice_Site_p.E43_splice|FOSB_uc010ekg.2_Intron|FOSB_uc002pca.3_5'UTR	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B						behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		tCACCCCGTAGGAGTGCGCCG	0.418			NA											23	111					0	0	0.003954	0	0
OPA3	80207	broad.mit.edu	37	19	46032614	46032614	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:46032614C>A	uc002pcj.3	-	2	343	c.243G>T	c.(241-243)GCG>GCT	p.A81A		NM_001017989	NP_001017989	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform a	81					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		CCAGCAGCTCCGCGCCCAGCT	0.622			NA											13	102					0.000219431	0.000244906	0.00245	1	0
NUCB1	4924	broad.mit.edu	37	19	49424449	49424449	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:49424449G>A	uc002plb.3	+	11	1113	c.1041G>A	c.(1039-1041)CTG>CTA	p.L347L	NUCB1_uc002pla.2_Silent_p.L347L|NUCB1_uc002plc.2_Silent_p.L347L|NUCB1_uc002pld.2_Silent_p.L10L	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	347	Potential.					ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		AGGAAGAGCTGAGGCGCTTTG	0.662			NA											3	23					0	0	0.009096	0	0
NLRP13	126204	broad.mit.edu	37	19	56413549	56413549	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:56413549C>A	uc010ygg.1	-	9	2666	c.2641G>T	c.(2641-2643)GCA>TCA	p.A881S		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	881							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAAGCGGGTGCTGCCAGCTGG	0.582			NA											9	23					1.58986e-06	1.91055e-06	0.008291	1	0
NLRP8	126205	broad.mit.edu	37	19	56482063	56482063	+	Splice_Site	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:56482063G>A	uc002qmh.2	+	6	2605	c.2534_splice	c.e6+1	p.S845_splice	NLRP8_uc010etg.2_Splice_Site_p.S845_splice	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8							cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AGAGGCTGTCGTAAGTCTCCT	0.468			NA											11	129					0	0	0.010729	0	0
USP29	57663	broad.mit.edu	37	19	57640047	57640047	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:57640047A>T	uc002qny.2	+	4	360	c.4A>T	c.(4-6)ATA>TTA	p.I2L		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	2					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGAAAGGATGATATCTCTAAA	0.333			NA											12	44					0	0	0.001368	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58849907	58849907	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:58849907A>G	uc002qsc.2	+	3	838	c.691A>G	c.(691-693)AGT>GGT	p.S231G	ZSCAN22_uc010yhz.1_Silent_p.L225L	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	231					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GAACAGTTCTAGTGCGTGGCC	0.522			NA											16	159					0	0	0.00499	0	0
LBH	81606	broad.mit.edu	37	2	30480308	30480308	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:30480308G>T	uc002rne.2	+	3	347	c.139G>T	c.(139-141)GAC>TAC	p.D47Y		NM_030915	NP_112177	Q53QV2	LBH_HUMAN	limb bud and heart development homolog	47					multicellular organismal development|transcription, DNA-dependent	cytoplasm|nucleolus					0	Acute lymphoblastic leukemia(172;0.155)					GATCTTCCCAGACCCGTCAGA	0.527			NA											7	50					1.6384e-10	2.19317e-10	0.001984	1	0
DYSF	8291	broad.mit.edu	37	2	71795348	71795348	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:71795348C>A	uc002sie.2	+	26	3066	c.2690C>A	c.(2689-2691)ACG>AAG	p.T897K	DYSF_uc010feg.2_Missense_Mutation_p.T928K|DYSF_uc010feh.2_Missense_Mutation_p.T883K|DYSF_uc002sig.3_Missense_Mutation_p.T883K|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.T897K|DYSF_uc010fef.2_Missense_Mutation_p.T914K|DYSF_uc010fei.2_Missense_Mutation_p.T914K|DYSF_uc010fek.2_Missense_Mutation_p.T915K|DYSF_uc010fej.2_Missense_Mutation_p.T884K|DYSF_uc010fel.2_Missense_Mutation_p.T884K|DYSF_uc010feo.2_Missense_Mutation_p.T929K|DYSF_uc010fem.2_Missense_Mutation_p.T898K|DYSF_uc010fen.2_Missense_Mutation_p.T915K|DYSF_uc002sif.2_Missense_Mutation_p.T898K	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	897	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TGGGGCACAACGGGCCTCACC	0.607			NA											22	199					2.27731e-05	2.61766e-05	0.012319	1	0
RANBP2	5903	broad.mit.edu	37	2	109367852	109367852	+	Nonsense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:109367852C>G	uc002tem.3	+	10	1532	c.1406C>G	c.(1405-1407)TCA>TGA	p.S469*		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	469					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CATGAAACCTCAAGGCTTGAA	0.338			NA											14	236					0	0	0.003163	0	0
ACMSD	130013	broad.mit.edu	37	2	135619539	135619539	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:135619539G>A	uc002ttz.2	+	4	267	c.200G>A	c.(199-201)GGA>GAA	p.G67E	ACMSD_uc002tua.2_Intron	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	67					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		CCATGTCTAGGAGTAACAGTG	0.512			NA											21	214					0	0	0.00278	0	0
LRP1B	53353	broad.mit.edu	37	2	141643712	141643712	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:141643712C>T	uc002tvj.1	-	24	4931	c.3959G>A	c.(3958-3960)AGT>AAT	p.S1320N	LRP1B_uc010fnl.1_Missense_Mutation_p.S502N	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1320	Extracellular (Potential).|LDL-receptor class B 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTACCTCCACTTTCAGAAAG	0.279	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			6	58					0	0	0.001168	0	0
LRP1B	53353	broad.mit.edu	37	2	141643856	141643856	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:141643856C>T	uc002tvj.1	-	24	4787	c.3815G>A	c.(3814-3816)AGG>AAG	p.R1272K	LRP1B_uc010fnl.1_Missense_Mutation_p.R454K	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1272	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGATCAATCCTTCTGATCTC	0.303	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			13	68					0	0	0.001855	0	0
LRP1B	53353	broad.mit.edu	37	2	141777540	141777540	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:141777540C>T	uc002tvj.1	-	12	2893	c.1921G>A	c.(1921-1923)GAG>AAG	p.E641K	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	641	Extracellular (Potential).|LDL-receptor class B 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTTCACCCTCTAAAAGAGTC	0.378	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			9	97					0	0	0.008291	0	0
NEB	4703	broad.mit.edu	37	2	152500637	152500637	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:152500637A>G	uc010fnx.2	-	57	7842	c.7651T>C	c.(7651-7653)TAC>CAC	p.Y2551H		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2551	Nebulin 68.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTTCCTTGTACTTGTACTAG	0.418			NA											33	178					0	0	0.004878	0	0
UPP2	151531	broad.mit.edu	37	2	158971692	158971692	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:158971692C>A	uc002tzp.2	+	3	454	c.260C>A	c.(259-261)GCT>GAT	p.A87D	UPP2_uc002tzo.2_Missense_Mutation_p.A144D	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	87					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						TTTGAGGAAGCTGAAGAAGAC	0.443			NA											11	76					1.08611e-07	1.36733e-07	0.010729	1	0
IFIH1	64135	broad.mit.edu	37	2	163134144	163134144	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:163134144C>T	uc002uce.2	-	10	2047	c.1825G>A	c.(1825-1827)GAG>AAG	p.E609K		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	609				E -> K (in Ref. 2; AAG54076).	detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						TGTAGGGCCTCATTGTACTTC	0.323			NA											5	64					0	0	0.001168	0	0
LRP2	4036	broad.mit.edu	37	2	170007439	170007439	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:170007439G>T	uc002ues.2	-	68	12772	c.12559C>A	c.(12559-12561)CCA>ACA	p.P4187T		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4187	Extracellular (Potential).|LDL-receptor class B 35.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATAGCAGCTGGTTGGTCCAGG	0.423			NA											12	79					3.07112e-06	3.63889e-06	0.010729	1	0
NFE2L2	4780	broad.mit.edu	37	2	178098846	178098846	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:178098846C>T	uc002ulh.3	-	2	754	c.199G>A	c.(199-201)GAG>AAG	p.E67K	NFE2L2_uc002ulg.3_Missense_Mutation_p.E51K|NFE2L2_uc010zfa.1_Missense_Mutation_p.E51K|NFE2L2_uc002uli.3_Missense_Mutation_p.E51K|NFE2L2_uc010fra.2_Missense_Mutation_p.E51K|NFE2L2_uc010frb.2_Missense_Mutation_p.E51K	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	67					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AAGGCTTTCTCTTGCTCCTTT	0.433			NA	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			6	71					0	0	0.001984	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187703805	187703805	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:187703805G>T	uc002upu.1	-	4	415	c.375C>A	c.(373-375)GAC>GAA	p.D125E		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	125					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GTTCATTTTCGTCATTTGTTC	0.403			NA											10	154					7.48243e-07	9.14759e-07	0.006214	1	0
C2orf47	79568	broad.mit.edu	37	2	200824549	200824549	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:200824549G>C	uc002uvm.2	+	4	917	c.595G>C	c.(595-597)GAT>CAT	p.D199H		NM_024520	NP_078796	Q8WWC4	CB047_HUMAN	hypothetical protein LOC79568 precursor	199						mitochondrion					0						TGCTAACATAGATGAAATTGT	0.358			NA											7	90					0	0	0.001984	0	0
IDH1	3417	broad.mit.edu	37	2	209113181	209113181	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:209113181C>T	uc002vcs.2	-	4	572	c.326G>A	c.(325-327)AGA>AAA	p.R109K	IDH1_uc002vct.2_Missense_Mutation_p.R109K|IDH1_uc002vcu.2_Missense_Mutation_p.R109K	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	109		Substrate.			2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		AATGGCTTCTCTGAAGACCGT	0.438	Pancreas(158;264 1958 3300 35450 36047)		NA	Mis		gliobastoma 								12	74					0	0	0.001368	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209142380	209142380	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:209142380C>T	uc002vcz.2	+	5	719	c.561C>T	c.(559-561)TTC>TTT	p.F187F	PIKFYVE_uc010fun.1_Intron|PIKFYVE_uc002vcy.1_Silent_p.F187F|PIKFYVE_uc002vcv.2_Intron|PIKFYVE_uc002vcw.2_Silent_p.F187F|PIKFYVE_uc002vcx.2_Intron	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	187	FYVE-type.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GGCAGATTTTCTGCAGTCGTT	0.388			NA											13	150					0	0	0.003163	0	0
DOCK10	55619	broad.mit.edu	37	2	225658141	225658141	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:225658141T>C	uc010fwz.1	-	46	5427	c.5188A>G	c.(5188-5190)ATT>GTT	p.I1730V	DOCK10_uc002vob.2_Missense_Mutation_p.I1724V|DOCK10_uc002voa.2_Missense_Mutation_p.I386V|DOCK10_uc002voc.2_Missense_Mutation_p.I584V	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1730	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TACTCTGCAATGAGAGCAGCA	0.373			NA											10	63					0	0	0.010729	0	0
WDR69	164781	broad.mit.edu	37	2	228786187	228786187	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:228786187C>T	uc002vpn.1	+	12	1202	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	WDR69_uc010zlw.1_Nonsense_Mutation_p.Q360*|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	375	WD 7.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CTGGGATGCTCAGACTGGCCA	0.433			NA											24	109					0	0	0.00333	0	0
TRPM8	79054	broad.mit.edu	37	2	234894470	234894470	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr2:234894470C>A	uc002vvh.2	+	21	2940	c.2900C>A	c.(2899-2901)ACC>AAC	p.T967N	TRPM8_uc010fyj.2_Missense_Mutation_p.T545N|TRPM8_uc010fyk.2_RNA	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	967	Helical; Name=6; (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ATGTTATCCACCAACATCCTG	0.567			NA											4	9					0.00909568	0.00957083	0.009096	1	0
PLCB1	23236	broad.mit.edu	37	20	8130941	8130941	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr20:8130941G>C	uc002wnb.2	+	2	103	c.100G>C	c.(100-102)GAC>CAC	p.D34H	PLCB1_uc010zrb.1_5'UTR|PLCB1_uc010gbv.1_Missense_Mutation_p.D34H|PLCB1_uc002wmz.1_Missense_Mutation_p.D34H|PLCB1_uc002wna.2_Missense_Mutation_p.D34H	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	34				MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDD -> MGS LQGIATKILIRILSDALIRKETDLKS (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ACATTTCTAGGACTCAACTAT	0.328			NA											11	57					0	0	0.008291	0	0
PLCB4	5332	broad.mit.edu	37	20	9417782	9417782	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr20:9417782G>T	uc002wnf.2	+	28	2847	c.2711G>T	c.(2710-2712)GGT>GTT	p.G904V	PLCB4_uc010gbw.1_Missense_Mutation_p.G904V|PLCB4_uc010gbx.2_Missense_Mutation_p.G916V|PLCB4_uc002wne.2_Missense_Mutation_p.G904V|PLCB4_uc002wnh.2_Missense_Mutation_p.G751V	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	904					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CTGGCCTCTGGTGTGGAAGCC	0.478			NA											3	22					0.00909568	0.00957083	0.009096	1	0
TRPC4AP	26133	broad.mit.edu	37	20	33665863	33665863	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr20:33665863G>C	uc002xbk.2	-	2	317	c.283C>G	c.(283-285)CAA>GAA	p.Q95E	TRPC4AP_uc002xbl.2_Missense_Mutation_p.Q95E|TRPC4AP_uc010zur.1_Missense_Mutation_p.Q95E|TRPC4AP_uc002xbm.1_Missense_Mutation_p.Q95E	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	95	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGGATGTTTTGACACTCAACA	0.498			NA											5	63					0	0	0.001168	0	0
SFRS6	6431	broad.mit.edu	37	20	42088452	42088452	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr20:42088452G>A	uc010zwg.1	+	3	468	c.298G>A	c.(298-300)GAC>AAC	p.D100N	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.D100N	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	100					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ATCTGGCAGAGACAAATACGG	0.398			NA											13	128					0	0	0.001368	0	0
SFRS6	6431	broad.mit.edu	37	20	42088829	42088829	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr20:42088829G>A	uc010zwg.1	+	4	708	c.538G>A	c.(538-540)GAA>AAA	p.E180K	SFRS6_uc002xki.2_Missense_Mutation_p.E51K|SFRS6_uc002xkk.2_Missense_Mutation_p.E180K	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	180	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TAGGCTTATTGAAGATAAGCC	0.423			NA											9	37					0	0	0.006214	0	0
L3MBTL	26013	broad.mit.edu	37	20	42162660	42162660	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr20:42162660C>T	uc010zwh.1	+	14	1506	c.1460C>T	c.(1459-1461)CCT>CTT	p.P487L	L3MBTL_uc002xkl.2_Missense_Mutation_p.P419L|L3MBTL_uc002xkm.2_Missense_Mutation_p.P419L|L3MBTL_uc010ggl.2_Missense_Mutation_p.P419L|L3MBTL_uc002xkn.1_Missense_Mutation_p.P178L|L3MBTL_uc002xko.2_Missense_Mutation_p.P71L	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	419					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TACCCAGACCCTGATAACTTC	0.577			NA											9	86					0	0	0.006214	0	0
EEF1A2	1917	broad.mit.edu	37	20	62126429	62126429	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr20:62126429G>T	uc002yfd.1	-	3	451	c.350C>A	c.(349-351)GCG>GAG	p.A117E	EEF1A2_uc002yfe.1_Missense_Mutation_p.A117E|EEF1A2_uc010gkg.1_Missense_Mutation_p.A117E	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	117						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CACGCCCGCCGCCACGATCAG	0.701			NA											6	57					5.18039e-06	6.10392e-06	0.00308	1	0
ITSN1	6453	broad.mit.edu	37	21	35229122	35229122	+	Silent	SNP	C	C	T	rs142988236		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr21:35229122C>T	uc002yta.1	+	30	4012	c.3744C>T	c.(3742-3744)ACC>ACT	p.T1248T	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Silent_p.T1243T|ITSN1_uc002ytj.2_Silent_p.T1243T|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yti.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1248	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						TCATTGTCACCGAGGAGAACT	0.547			NA											5	40					0	0	0.000602	0	0
COL6A1	1291	broad.mit.edu	37	21	47410956	47410956	+	Splice_Site	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr21:47410956G>A	uc002zhu.1	+	15	1221	c.1119_splice	c.e15+1	p.K373_splice		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor						axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AGGAGAAAAGGTGAGTGACTT	0.607			NA											3	25					0	0	0.004672	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30688415	30688415	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr22:30688415G>T	uc011akt.1	-	11	1500	c.1476C>A	c.(1474-1476)CAC>CAA	p.H492Q	GATSL3_uc003ahc.2_5'Flank|GATSL3_uc003ahe.2_5'Flank|GATSL3_uc003ahd.2_5'Flank|GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|GATSL3_uc010gvr.2_5'Flank|GATSL3_uc010gvs.2_5'Flank|TBC1D10A_uc003ahj.3_Missense_Mutation_p.H404Q|TBC1D10A_uc010gvu.2_Missense_Mutation_p.H499Q|TBC1D10A_uc003ahk.3_Missense_Mutation_p.H492Q	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	492						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CCTGGGAGCGGTGGTGGGCTG	0.612			NA											13	181					0.00185496	0.00199656	0.001855	1	0
LARGE	9215	broad.mit.edu	37	22	33700318	33700318	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr22:33700318C>A	uc003and.3	-	13	2206	c.1627G>T	c.(1627-1629)GTG>TTG	p.V543L	LARGE_uc011amd.1_Missense_Mutation_p.V342L|LARGE_uc003ane.3_Missense_Mutation_p.V543L|LARGE_uc010gwp.2_Missense_Mutation_p.V491L|LARGE_uc011ame.1_Missense_Mutation_p.V475L|LARGE_uc011amf.1_Missense_Mutation_p.V543L	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	543	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				AGCAGGTTCACGGGGTAGAAC	0.572	Colon(70;397 1175 4573 19089 45288)		NA											7	80					2.17888e-05	2.51135e-05	0.006214	1	0
CSNK1E	1454	broad.mit.edu	37	22	38696822	38696822	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr22:38696822C>T	uc003avj.2	-	5	733	c.472G>A	c.(472-474)GAC>AAC	p.D158N	CSNK1E_uc003avk.2_Missense_Mutation_p.D158N|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.D158N|CSNK1E_uc003avo.2_Missense_Mutation_p.D158N|CSNK1E_uc003avp.1_Missense_Mutation_p.D158N|CSNK1E_uc003avq.1_Missense_Mutation_p.D158N	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	158	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					GTGCGGGCGTCCCGGTACTTC	0.617	Esophageal Squamous(119;108 755 9651 12170 13692 17603 24932 28315 37982 41601)		NA											5	69					0	0	0.000602	0	0
GRM7	2917	broad.mit.edu	37	3	7503364	7503364	+	Silent	SNP	G	G	C	rs138702582		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:7503364G>C	uc003bqm.2	+	7	1744	c.1470G>C	c.(1468-1470)CCG>CCC	p.P490P	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.P490P|GRM7_uc003bql.2_Silent_p.P490P|GRM7_uc003bqn.1_Silent_p.P73P|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	490	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CCAGCAACCCGGGTTACCGTC	0.488			NA											7	110					0	0	0.004482	0	0
TIMP4	7079	broad.mit.edu	37	3	12200325	12200325	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:12200325G>C	uc003bwo.2	-	1	323	c.16C>G	c.(16-18)CGG>GGG	p.R6G	SYN2_uc003bwl.1_Intron|SYN2_uc003bwm.2_Intron|SYN2_uc003bwn.2_Intron	NM_003256	NP_003247	Q99727	TIMP4_HUMAN	tissue inhibitor of metalloproteinase 4	6							metal ion binding|metalloendopeptidase inhibitor activity				0						GGCGCGGGCCGAGGGCTCCCA	0.721	Melanoma(199;1446 2144 30617 38794 51714)		NA											3	12					0	0	0.004672	0	0
ZNF385D	79750	broad.mit.edu	37	3	21706452	21706452	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:21706452G>A	uc003cce.2	-	2	499	c.91C>T	c.(91-93)CTG>TTG	p.L31L	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	31						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						TTAATATCCAGCGATGGTTGC	0.517			NA											10	43					0	0	0.008291	0	0
DCLK3	85443	broad.mit.edu	37	3	36778975	36778975	+	Silent	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:36778975G>C	uc003cgi.2	-	2	1667	c.1176C>G	c.(1174-1176)CTC>CTG	p.L392L		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	392	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						CCTTGCCCTTGAGTCTGGACT	0.527			NA											7	40					0	0	0.001984	0	0
XYLB	9942	broad.mit.edu	37	3	38415993	38415993	+	Silent	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:38415993G>T	uc003cic.2	+	11	997	c.888G>T	c.(886-888)GCG>GCT	p.A296A	XYLB_uc011ayp.1_Silent_p.A159A|XYLB_uc003cid.1_Silent_p.A218A	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	296					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		GTGACATTGCGGTAAGGCGAC	0.562			NA											6	29					8.12818e-05	9.14421e-05	0.001984	1	0
SETD2	29072	broad.mit.edu	37	3	47162194	47162194	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:47162194C>T	uc003cqs.2	-	3	3985	c.3932G>A	c.(3931-3933)GGT>GAT	p.G1311D	SETD2_uc003cqv.2_Missense_Mutation_p.G1300D	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AGGAGGTCTACCTGATCTTGG	0.468			NA	N|F|S|Mis		clear cell renal carcinoma								5	67					0	0	0.000602	0	0
MST1R	4486	broad.mit.edu	37	3	49927461	49927461	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:49927461C>A	uc003cxy.3	-	19	4107	c.3843G>T	c.(3841-3843)CTG>CTT	p.L1281L	MST1R_uc011bdc.1_Silent_p.L160L	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1281	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CACCCCGTGTCAGCAGTTCCC	0.617			NA											5	35					1.23904e-05	1.43987e-05	0.000602	1	0
FAM86D	692099	broad.mit.edu	37	3	75475709	75475709	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:75475709T>C	uc003dpp.3	-	7	888	c.529A>G	c.(529-531)ATC>GTC	p.I177V	FAM86D_uc003dpo.3_RNA|FAM86D_uc003dps.3_RNA|FAM86D_uc003dpq.3_Missense_Mutation_p.I85V|FAM86D_uc003dpr.3_RNA	NR_024241				RecName: Full=Protein FAM86B1;												0						CTCCGCAGGATCCCGACCAGC	0.562			NA											3	16					0	0	0.004672	0	0
EPHA3	2042	broad.mit.edu	37	3	89521672	89521672	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:89521672G>T	uc003dqy.2	+	16	2974	c.2749G>T	c.(2749-2751)GGT>TGT	p.G917C	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	917	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCGCACAACAGGTGACTGGCT	0.463			NA								TSP Lung(6;0.00050)			11	126					2.27111e-07	2.83386e-07	0.001368	1	0
ZPLD1	131368	broad.mit.edu	37	3	102171778	102171778	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:102171778G>T	uc003dvs.1	+	10	1004	c.122G>T	c.(121-123)AGT>ATT	p.S41I	ZPLD1_uc003dvt.1_Missense_Mutation_p.S57I|ZPLD1_uc011bhg.1_Missense_Mutation_p.S41I	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	41	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						AGAGACATCAGTGTCTATTGT	0.333			NA											6	93					0.00198382	0.00211908	0.001984	1	0
CBLB	868	broad.mit.edu	37	3	105456052	105456052	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:105456052C>G	uc003dwc.2	-	8	1356	c.1034G>C	c.(1033-1035)TGT>TCT	p.C345S	CBLB_uc011bhi.1_Missense_Mutation_p.C367S|CBLB_uc003dwd.1_Missense_Mutation_p.C345S|CBLB_uc003dwe.1_Missense_Mutation_p.C345S|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	345	Linker.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TGTAGGTTCACATAATCCAGT	0.284	GBM(93;588 1337 9788 29341 43499)		NA	Mis S		AML								6	54					0	0	0.001984	0	0
KIAA1524	57650	broad.mit.edu	37	3	108278606	108278606	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:108278606C>G	uc003dxb.3	-	16	2280	c.2011G>C	c.(2011-2013)GAG>CAG	p.E671Q		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	671	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						CTACACACCTCTGTTTCAGCT	0.343			NA											3	28					0	0	0.004672	0	0
ABHD10	55347	broad.mit.edu	37	3	111710449	111710449	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:111710449G>T	uc003dyk.3	+	5	883	c.802G>T	c.(802-804)GAT>TAT	p.D268Y	ABHD10_uc011bhq.1_Missense_Mutation_p.D111Y	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	268						mitochondrion	serine-type peptidase activity				0						ACTCAGCACAGATGTGGATGT	0.428			NA											9	99					0.000442599	0.000486284	0.006214	1	0
KIAA2018	205717	broad.mit.edu	37	3	113388995	113388995	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:113388995C>T	uc003eam.2	-	5	543	c.132G>A	c.(130-132)CTG>CTA	p.L44L	KIAA2018_uc003eal.2_5'UTR	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	44	Helix-loop-helix motif.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						AACATGGGATCAGCTCTCCTA	0.383			NA											7	77					0	0	0.00308	0	0
LSAMP	4045	broad.mit.edu	37	3	115560692	115560692	+	Nonsense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:115560692T>A	uc003ebt.2	-	6	1419	c.919A>T	c.(919-921)AGA>TGA	p.R307*	LSAMP_uc011bis.1_Nonsense_Mutation_p.K307*	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	307					cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GCATACTTACTGAAAAGGACT	0.458			NA											8	45					0	0	0.004482	0	0
EPHB1	2047	broad.mit.edu	37	3	134670588	134670588	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:134670588C>G	uc003eqt.2	+	3	719	c.499C>G	c.(499-501)CCT>GCT	p.P167A	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Intron	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	167	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.P167L(1)		lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GAGCTTTGGGCCTCTTACTCG	0.473			NA											17	215					0	0	0.00499	0	0
CLDN18	51208	broad.mit.edu	37	3	137717828	137717828	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:137717828G>A	uc003ero.1	+	1	171	c.118G>A	c.(118-120)GTA>ATA	p.V40I		NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	40	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						CAACAACCCCGTAACAGCTGT	0.592			NA											10	75					0	0	0.006214	0	0
NAALADL2	254827	broad.mit.edu	37	3	175184875	175184875	+	Nonsense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:175184875C>G	uc003fit.2	+	8	1523	c.1436C>G	c.(1435-1437)TCA>TGA	p.S479*	NAALADL2_uc003fiu.1_Nonsense_Mutation_p.S472*|NAALADL2_uc010hwy.1_Nonsense_Mutation_p.S253*|NAALADL2_uc010hwz.1_Nonsense_Mutation_p.S73*	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	479	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GCCTTGATGTCAAAAGTTAAG	0.443			NA											15	124					0	0	0.003163	0	0
NDUFB5	4711	broad.mit.edu	37	3	179332786	179332786	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:179332786G>T	uc003fkc.2	+	2	181	c.152G>T	c.(151-153)GGG>GTG	p.G51V	NDUFB5_uc003fkd.2_RNA|NDUFB5_uc003fke.2_Intron	NM_002492	NP_002483	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	51					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			skin(1)	1	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	GGAGACCATGGGAAAAGACTA	0.343			NA											12	81					0.000308642	0.000340876	0.003163	1	0
UTS2D	257313	broad.mit.edu	37	3	190993092	190993092	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr3:190993092C>A	uc003fsu.2	-	8	1070	c.283G>T	c.(283-285)GAG>TAG	p.E95*		NM_198152	NP_937795	Q765I0	UTS2B_HUMAN	urotensin 2 domain containing precursor	95						extracellular region	hormone activity				0	all_cancers(143;1.77e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000214)		TAGGACGTCTCAGAATCCTTC	0.338			NA											26	115					8.58068e-18	1.22623e-17	0.007291	1	0
ZNF718	255403	broad.mit.edu	37	4	53277	53277	+	Translation_Start_Site	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:53277G>T	uc003fzt.3	+	2	28	c.-105G>T	c.(-107--103)TAGGG>TATGG		ZNF595_uc003fzu.1_RNA|ZNF595_uc010iay.1_RNA|ZNF595_uc003fzv.1_5'UTR|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_5'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		TCTCGGCTCCGGGAGGCCTCG	0.602			NA											5	77					3.59834e-05	4.11377e-05	0.001168	1	0
PPP2R2C	5522	broad.mit.edu	37	4	6473956	6473956	+	Missense_Mutation	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:6473956T>C	uc003gjc.2	-	1	371	c.1A>G	c.(1-3)ATG>GTG	p.M1V	PPP2R2C_uc011bwd.1_Intron|PPP2R2C_uc011bwe.1_Intron	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	1					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						TCCTCGCCCATTGAAGGCCGT	0.657			NA											11	70					0	0	0.010729	0	0
KIAA0232	9778	broad.mit.edu	37	4	6863504	6863504	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:6863504C>T	uc003gjr.3	+	7	1858	c.1395C>T	c.(1393-1395)TTC>TTT	p.F465F	KIAA0232_uc003gjq.3_Silent_p.F465F	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	465							ATP binding			ovary(2)	2						CAGGTACTTTCATTGATGGTC	0.398			NA											9	98					0	0	0.004482	0	0
GBA3	57733	broad.mit.edu	37	4	22748963	22748963	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:22748963G>C	uc003gqp.3	+	3	422	c.331G>C	c.(331-333)GGG>CGG	p.G111R	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.G112R	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	111					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						GTTAAAAAATGGGGTTACTCC	0.373			NA											16	177					0	0	0.004007	0	0
ARAP2	116984	broad.mit.edu	37	4	36069551	36069551	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:36069551T>A	uc003gsq.1	-	33	5431	c.5093A>T	c.(5092-5094)CAG>CTG	p.Q1698L	ARAP2_uc003gso.2_Intron	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1698					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTGCTCATCCTGTAATTCTTT	0.338			NA											14	83					0	0	0.001855	0	0
TLR10	81793	broad.mit.edu	37	4	38776982	38776983	+	Missense_Mutation	DNP	AA	AA	TT			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	AA	AA	-	-	AA	AA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:38776982_38776983AA>TT	uc003gti.2	-	2	608_609	c.229_230TT>AA	c.(229-231)TTG>AAG	p.L77K	TLR10_uc003gtj.2_Missense_Mutation_p.L77K|TLR10_uc003gtk.2_Missense_Mutation_p.L77K	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	77	LRR 3.|Extracellular (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						GCATAGAATCAAAACTCTCAGT	0.381			NA											12	62					0	0	0.004672	0	0
APBB2	323	broad.mit.edu	37	4	40827964	40827964	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:40827964C>T	uc003gvl.2	-	15	2383	c.1753G>A	c.(1753-1755)GAG>AAG	p.E585K	APBB2_uc010ifu.2_Missense_Mutation_p.E157K|APBB2_uc003gvm.2_Missense_Mutation_p.E563K|APBB2_uc003gvn.2_Missense_Mutation_p.E586K|APBB2_uc003gvk.2_Missense_Mutation_p.E37K	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	585	PID 2.				cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						TGGACCAGCTCAGTCTTTGGT	0.448	Ovarian(3;20 75 16686 49997)		NA											16	109					0	0	0.004007	0	0
WDFY3	23001	broad.mit.edu	37	4	85707201	85707201	+	Silent	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:85707201C>A	uc003hpd.2	-	24	4401	c.3993G>T	c.(3991-3993)GTG>GTT	p.V1331V		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1331						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTAGAGACGACACAGAGAGTG	0.443			NA											11	101					0.00136819	0.00148017	0.001368	1	0
WDFY3	23001	broad.mit.edu	37	4	85707203	85707203	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:85707203C>A	uc003hpd.2	-	24	4399	c.3991G>T	c.(3991-3993)GTG>TTG	p.V1331L		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1331						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGAGACGACACAGAGAGTGCA	0.433			NA											11	105					0.00136819	0.00148017	0.001368	1	0
PDHA2	5161	broad.mit.edu	37	4	96761377	96761377	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:96761377C>A	uc003htr.3	+	1	139	c.76C>A	c.(76-78)CGT>AGT	p.R26S		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	26					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GGTGGCATCCCGTAACTCCTC	0.522			NA											3	26					6.4e-05	7.25951e-05	0.004672	1	0
NHEDC2	133308	broad.mit.edu	37	4	103950041	103950041	+	Splice_Site	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:103950041C>T	uc003hwx.3	-	11	2128	c.1256_splice	c.e11-1	p.G419_splice	NHEDC2_uc010iln.1_Intron|NHEDC2_uc003hwy.2_Splice_Site_p.G419_splice|NHEDC2_uc011cew.1_Splice_Site_p.G362_splice|NHEDC2_uc011cex.1_Intron	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2						sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		ACACAAAGGCCTGTAAGAAAT	0.299			NA											4	44					0	0	0.009096	0	0
C4orf3	401152	broad.mit.edu	37	4	120221511	120221511	+	Silent	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:120221511G>C	uc003icv.3	-	1	458	c.180C>G	c.(178-180)CTC>CTG	p.L60L		NM_001001701	NP_001001701	Q8WVX3	CD003_HUMAN	hypothetical protein LOC401152	60	Helical; (Potential).					integral to membrane					0						AATACACAAAGAGAAACACCA	0.328			NA											7	132					0	0	0.00308	0	0
ADAD1	132612	broad.mit.edu	37	4	123333743	123333743	+	Missense_Mutation	SNP	A	A	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:123333743A>C	uc003ieo.2	+	10	1260	c.1028A>C	c.(1027-1029)AAT>ACT	p.N343T	ADAD1_uc003iep.2_Missense_Mutation_p.N332T|ADAD1_uc003ieq.2_Missense_Mutation_p.N325T	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	343	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						AGACGTCTTAATCCACATTCT	0.363			NA											12	142					0	0	0.001368	0	0
PHF17	79960	broad.mit.edu	37	4	129767550	129767550	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:129767550C>T	uc003igk.2	+	4	439	c.159C>T	c.(157-159)ATC>ATT	p.I53I	PHF17_uc003igj.2_Silent_p.I53I|PHF17_uc003igl.2_Silent_p.I53I|PHF17_uc011cgy.1_Silent_p.I53I|PHF17_uc003igm.2_Silent_p.I53I	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	53					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						CAGACCTGATCACTGCCATGA	0.483			NA											27	172					0	0	0.009535	0	0
PCDH10	57575	broad.mit.edu	37	4	134072378	134072378	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:134072378C>G	uc003iha.2	+	1	1909	c.1083C>G	c.(1081-1083)AGC>AGG	p.S361R	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.S361R	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	361	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TCAGCTTCAGCACCGTGAAGG	0.627			NA											6	55					0	0	0.001168	0	0
FSTL5	56884	broad.mit.edu	37	4	162680590	162680590	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:162680590C>G	uc003iqh.2	-	6	1136	c.700G>C	c.(700-702)GCT>CCT	p.A234P	FSTL5_uc003iqi.2_Missense_Mutation_p.A233P|FSTL5_uc010iqv.2_Missense_Mutation_p.A233P	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	234	2 (Potential).|EF-hand 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCTTCAAGAGCCAGGTGCTTG	0.348			NA											10	82					0	0	0.006214	0	0
SORBS2	8470	broad.mit.edu	37	4	186544288	186544288	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:186544288G>A	uc003iyl.2	-	13	3141	c.2283C>T	c.(2281-2283)ATC>ATT	p.I761I	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Silent_p.I861I|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Silent_p.I665I|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Silent_p.I875I|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	761						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GCAGCTCACTGATGAGGCGGT	0.572	Esophageal Squamous(153;41 2433 9491 36028)		NA											26	248					0	0	0.008361	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	182155	182155	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:182155C>T	uc003jak.2	+	18	3583	c.3533C>T	c.(3532-3534)TCT>TTT	p.S1178F		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1178	Ser-rich.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GTGTCCTCCTCTGACCACGCC	0.617			NA											10	57					0	0	0.008291	0	0
TRIP13	9319	broad.mit.edu	37	5	911998	911998	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:911998G>A	uc003jbr.2	+	10	1017	c.907G>A	c.(907-909)GAG>AAG	p.E303K		NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	303					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			TAACATCACCGAGAAGATCGA	0.512			NA											9	90					0	0	0.004482	0	0
TRIO	7204	broad.mit.edu	37	5	14508363	14508363	+	Silent	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:14508363G>C	uc003jff.2	+	57	9132	c.9126G>C	c.(9124-9126)GCG>GCC	p.A3042A	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	3042	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.A3042V(1)		skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CCTCGGCTGCGCTGGCCCTCC	0.617			NA											16	51					0	0	0.004007	0	0
PRDM9	56979	broad.mit.edu	37	5	23522899	23522899	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:23522899G>A	uc003jgo.2	+	8	969	c.787G>A	c.(787-789)GAG>AAG	p.E263K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	263	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGTATGGAATGAGGCATCTGA	0.577			NA								HNSCC(3;0.000094)			4	54					0	0	0.009096	0	0
CDH10	1008	broad.mit.edu	37	5	24535931	24535931	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:24535931C>A	uc003jgr.1	-	4	859	c.527G>T	c.(526-528)GGT>GTT	p.G176V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	176	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CACAGAAGTACCTGAAGTATC	0.443			NA								HNSCC(23;0.051)			18	43					5.03518e-11	6.78307e-11	0.007413	1	0
NPR3	4883	broad.mit.edu	37	5	32712263	32712263	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:32712263G>T	uc003jhv.2	+	1	599	c.381G>T	c.(379-381)AAG>AAT	p.K127N	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.K127N	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	127	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GGGGCGCCAAGCCAGACCTTA	0.687			NA											8	122					0.00621372	0.00658747	0.006214	1	0
NIPBL	25836	broad.mit.edu	37	5	36976076	36976076	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:36976076C>T	uc003jkl.3	+	9	1566	c.1067C>T	c.(1066-1068)ACT>ATT	p.T356I	NIPBL_uc003jkk.3_Missense_Mutation_p.T356I|NIPBL_uc003jkm.1_Missense_Mutation_p.T235I	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	356					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AAGGACTCTACTAAACTTACA	0.368			NA											20	64					0	0	0.010504	0	0
ITGA1	3672	broad.mit.edu	37	5	52240860	52240860	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:52240860A>G	uc003jou.2	+	27	3425	c.3373A>G	c.(3373-3375)AGA>GGA	p.R1125G	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.R656G	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	1125	Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				CAATCAAAAAAGAGAGGTAAG	0.333			NA											15	128					0	0	0.003163	0	0
MAP3K1	4214	broad.mit.edu	37	5	56189376	56189376	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:56189376G>T	uc003jqw.3	+	20	4909	c.4408G>T	c.(4408-4410)GCT>TCT	p.A1470S		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	1470	Protein kinase.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		TGCAACTACTGCTCCATCGAT	0.448			NA											4	41					2.0095e-06	2.38769e-06	0.001984	1	0
TAF9	6880	broad.mit.edu	37	5	68661433	68661433	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:68661433G>C	uc003jwc.1	-	2	464	c.132C>G	c.(130-132)TTC>TTG	p.F44L	TAF9_uc003jwa.2_Intron|TAF9_uc003jwb.2_Intron|TAF9_uc003jwd.1_Missense_Mutation_p.F44L|TAF9_uc003jwe.1_Missense_Mutation_p.F44L|TAF9_uc003jwf.1_Missense_Mutation_p.F44L	NM_003187	NP_003178	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	44					histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		TCACATATCGGAAGGCAAACT	0.418			NA											24	145					0	0	0.00278	0	0
SV2C	22987	broad.mit.edu	37	5	75490824	75490824	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:75490824C>T	uc003kei.1	+	3	795	c.661C>T	c.(661-663)CTT>TTT	p.L221F		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	221	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GAAACAGTCTCTTCTGATTTG	0.478			NA											28	258					0	0	0.007291	0	0
MCC	4163	broad.mit.edu	37	5	112418659	112418659	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:112418659C>G	uc003kqj.3	-	9	1642	c.1112G>C	c.(1111-1113)TGC>TCC	p.C371S	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.C561S|MCC_uc011cwb.1_Missense_Mutation_p.C371S|MCC_uc010jcd.1_Missense_Mutation_p.C333S	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	371					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GATATTGGAGCAGTCCTGAAG	0.448			NA											6	69					0	0	0.001168	0	0
HSPA4	3308	broad.mit.edu	37	5	132439557	132439557	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:132439557G>T	uc003kyj.2	+	18	2439	c.2158G>T	c.(2158-2160)GAG>TAG	p.E720*		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	720					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGGTTGCAGGAGGACCAGTA	0.408	Colon(114;1299 1588 6063 12302 48757)		NA											7	78					2.7689e-08	3.5385e-08	0.001984	1	0
HSPA4	3308	broad.mit.edu	37	5	132439655	132439655	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:132439655G>A	uc003kyj.2	+	18	2537	c.2256G>A	c.(2254-2256)CAG>CAA	p.Q752Q		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	752					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TAAATCTGCAGAACAAGCAGA	0.358	Colon(114;1299 1588 6063 12302 48757)		NA											7	77					0	0	0.001984	0	0
SEC24A	10802	broad.mit.edu	37	5	134023904	134023904	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:134023904C>T	uc003kzs.2	+	11	1926	c.1638C>T	c.(1636-1638)TTC>TTT	p.F546F	SEC24A_uc011cxu.1_Silent_p.F310F	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	546					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAATTGGCTTCATAACATTTG	0.323			NA											7	90					0	0	0.00308	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209494	140209494	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:140209494G>T	uc003lho.2	+	1	1845	c.1818G>T	c.(1816-1818)TGG>TGT	p.W606C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.W606C	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	606	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACGCGTGGCTTTCGTATG	0.657			NA											8	51					1.12685e-05	1.32038e-05	0.004482	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256157	140256157	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:140256157C>T	uc003lic.2	+	1	1227	c.1100C>T	c.(1099-1101)ACC>ATC	p.T367I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.T367I	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	367	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGTGGGTACCGTCATTGCC	0.532	Pancreas(113;759 1672 13322 24104 50104)		NA											8	48					0	0	0.00308	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730766	140730766	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:140730766G>C	uc003ljo.1	+	1	939	c.939G>C	c.(937-939)TTG>TTC	p.L313F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.L313F	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	313	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATATGTGTTGAGTGTGGAAG	0.418			NA											7	100					0	0	0.00308	0	0
ARAP3	64411	broad.mit.edu	37	5	141036183	141036183	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:141036183C>A	uc003llm.2	-	27	3755	c.3677G>T	c.(3676-3678)CGG>CTG	p.R1226L	ARAP3_uc003lll.2_Missense_Mutation_p.R177L|ARAP3_uc011dbe.1_Missense_Mutation_p.R888L|ARAP3_uc003lln.2_Missense_Mutation_p.R1057L	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1226	PH 3.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CAGCCCCACCCGTGGGCTCTC	0.642			NA											5	11					5.9392e-07	7.28198e-07	0.001168	1	0
PCDH1	5097	broad.mit.edu	37	5	141243094	141243094	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:141243094C>T	uc003llq.2	-	3	2919	c.2802G>A	c.(2800-2802)CAG>CAA	p.Q934Q	PCDH1_uc003llp.2_Silent_p.Q934Q|PCDH1_uc011dbf.1_Silent_p.Q912Q	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	934	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TGAGGGACTTCTGCAGCCCGG	0.622	Ovarian(132;1609 1739 4190 14731 45037)		NA											4	19					0	0	0.009096	0	0
POU4F3	5459	broad.mit.edu	37	5	145719212	145719212	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:145719212C>A	uc003loa.2	+	2	311	c.222C>A	c.(220-222)TTC>TTA	p.F74L		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	74					sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCATCCGTTCAAGCCCGACG	0.607			NA											4	50					0.00116845	0.00127057	0.001168	1	0
CYFIP2	26999	broad.mit.edu	37	5	156746826	156746826	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:156746826C>T	uc003lwq.2	+	16	1551	c.1413C>T	c.(1411-1413)TTC>TTT	p.F471F	CYFIP2_uc011ddn.1_Silent_p.F445F|CYFIP2_uc011ddo.1_Silent_p.F275F|CYFIP2_uc003lwr.2_Silent_p.F471F|CYFIP2_uc003lws.2_Silent_p.F471F|CYFIP2_uc003lwt.2_Silent_p.F349F|CYFIP2_uc011ddp.1_Silent_p.F205F	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	471					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAGCGTCTTCAACCAGGCCA	0.597			NA											7	63					0	0	0.001984	0	0
GABRA1	2554	broad.mit.edu	37	5	161277868	161277868	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:161277868C>T	uc010jiw.2	+	3	520	c.52C>T	c.(52-54)CTG>TTG	p.L18L	GABRA1_uc010jix.2_Silent_p.L18L|GABRA1_uc010jiy.2_Silent_p.L18L|GABRA1_uc003lyx.3_Silent_p.L18L|GABRA1_uc010jiz.2_Silent_p.L18L|GABRA1_uc010jja.2_Silent_p.L18L|GABRA1_uc010jjb.2_Silent_p.L18L	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	18					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GATCCTCCTTCTGAGCACACT	0.428			NA											7	82					0	0	0.006214	0	0
C5orf25	375484	broad.mit.edu	37	5	175722195	175722195	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:175722195A>T	uc003mds.3	+	5	1944	c.1537A>T	c.(1537-1539)ATC>TTC	p.I513F	C5orf25_uc003mdt.3_Missense_Mutation_p.I98F|C5orf25_uc003mdr.3_RNA|C5orf25_uc011dfk.1_Missense_Mutation_p.I532F			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	513											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		CATCCAGAAAATCTTGCTCAG	0.468			NA											8	26					0	0	0.004482	0	0
MAML1	9794	broad.mit.edu	37	5	179192648	179192648	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:179192648A>T	uc003mkm.2	+	2	900	c.637A>T	c.(637-639)AAT>TAT	p.N213Y	MAML1_uc003mkn.1_Missense_Mutation_p.N213Y	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	213					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTGAGCCTGAATAAAGAACT	0.522			NA											11	38					0	0	0.010729	0	0
OR2V2	285659	broad.mit.edu	37	5	180582569	180582569	+	Silent	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:180582569C>G	uc011dhj.1	+	1	627	c.627C>G	c.(625-627)CTC>CTG	p.L209L		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCATGCTTCTCTTCCCATTCT	0.498			NA											13	163					0	0	0.001855	0	0
GNB2L1	10399	broad.mit.edu	37	5	180668575	180668575	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr5:180668575C>T	uc003mni.1	-	3	452	c.346G>A	c.(346-348)GAC>AAC	p.D116N	GNB2L1_uc003mnh.1_Missense_Mutation_p.D75N|GNB2L1_uc003mnk.1_Missense_Mutation_p.D38N|GNB2L1_uc003mnj.1_Missense_Mutation_p.D70N|GNB2L1_uc003mnl.1_5'UTR|GNB2L1_uc011dhk.1_Missense_Mutation_p.D116N|GNB2L1_uc010jls.2_Missense_Mutation_p.D75N|GNB2L1_uc011dhl.1_Missense_Mutation_p.D116N	NM_006098	NP_006089	P63244	GBLP_HUMAN	guanine nucleotide binding protein (G protein),	116	WD 3.				apoptosis|cell cycle|gastrulation|interspecies interaction between organisms|negative regulation of cell growth|negative regulation of phagocytosis|negative regulation of translation|negative regulation of Wnt receptor signaling pathway|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of gastrulation|positive regulation of GTPase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|positive regulation of protein phosphorylation|regulation of cell cycle|regulation of cell division|regulation of establishment of cell polarity|regulation of protein localization|rhythmic process	cytoskeleton|dendrite|midbody|nucleus|perikaryon|perinuclear region of cytoplasm|phagocytic cup|small ribosomal subunit	ion channel inhibitor activity|protein kinase C binding|protein phosphatase binding|protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|SH2 domain binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.101)|all cancers(165;0.11)		TGCCGGTTGTCAGAGGAGAAG	0.512			NA											5	88					0	0	0.001168	0	0
DUSP22	56940	broad.mit.edu	37	6	345916	345916	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:345916G>T	uc003msx.2	+	5	690	c.251G>T	c.(250-252)TGC>TTC	p.C84F	DUSP22_uc011dhn.1_Missense_Mutation_p.C84F|DUSP22_uc003msy.1_Missense_Mutation_p.C41F	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	84	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GGTGAGAGCTGCCTTGTACAC	0.443			NA											6	89					0.00116845	0.00127057	0.001168	1	0
SLC17A4	10050	broad.mit.edu	37	6	25762199	25762200	+	Nonsense_Mutation	DNP	CG	CG	AT			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:25762199_25762200CG>AT	uc003nfe.2	+	2	128_129	c.9_10CG>AT	c.(7-12)ACCGGA>ACATGA	p.G4*	SLC17A4_uc011djx.1_Nonsense_Mutation_p.G4*|SLC17A4_uc003nff.1_Translation_Start_Site|SLC17A4_uc003nfg.2_Translation_Start_Site	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	4					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						AAATGTCTACCGGACCAGATGT	0.401			NA											6	37					0	0	0.004672	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273272	26273272	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:26273272G>C	uc003nhk.2	+	1	69	c.69G>C	c.(67-69)CAG>CAC	p.Q23H	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	23					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CCAAGGCACAGAAGAAGGATG	0.582			NA											15	162					0	0	0.003163	0	0
BTN3A3	10384	broad.mit.edu	37	6	26452057	26452057	+	Silent	SNP	A	A	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:26452057A>C	uc003nhz.2	+	11	1353	c.1173A>C	c.(1171-1173)ACA>ACC	p.T391T	BTN3A3_uc003nia.2_Silent_p.T349T|BTN3A3_uc011dkn.1_Silent_p.T342T	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	391	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						AAAACTTCACATCAGGGAGAC	0.502			NA											5	41					0	0	0.000602	0	0
BTN2A1	11120	broad.mit.edu	37	6	26468505	26468505	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:26468505G>A	uc003nib.1	+	8	1524	c.1312G>A	c.(1312-1314)GAT>AAT	p.D438N	BTN2A1_uc003nic.1_3'UTR|BTN2A1_uc003nid.1_Missense_Mutation_p.D286N|BTN2A1_uc011dko.1_Missense_Mutation_p.D377N|BTN2A1_uc010jqk.1_Missense_Mutation_p.D198N	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	438	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						GTCCTCCCCTGATAGGATTCT	0.537			NA											7	66					0	0	0.001984	0	0
OR10C1	442194	broad.mit.edu	37	6	29407927	29407927	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:29407927G>A	uc011dlp.1	+	1	135	c.135G>A	c.(133-135)GTG>GTA	p.V45V	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTCATTGTGGTGCTGGTCT	0.572			NA											17	98					0	0	0.004007	0	0
C6orf15	29113	broad.mit.edu	37	6	31079340	31079340	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:31079340G>A	uc003nsk.1	-	2	796	c.796C>T	c.(796-798)CGG>TGG	p.R266W		NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	266	Gly-rich.										0						CCTGGATACCGATTAATATTT	0.498			NA											5	71					0	0	0.001168	0	0
MSH5	4439	broad.mit.edu	37	6	31726640	31726640	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:31726640C>G	uc003nwv.1	+	15	1393	c.1314C>G	c.(1312-1314)ATC>ATG	p.I438M	MSH5_uc003nwt.1_Missense_Mutation_p.I455M|MSH5_uc003nwu.1_Missense_Mutation_p.I438M|MSH5_uc003nww.1_Missense_Mutation_p.I438M|MSH5_uc003nwx.1_Missense_Mutation_p.I455M|MSH5_uc011dof.1_Missense_Mutation_p.I137M|MSH5_uc003nwy.1_Missense_Mutation_p.I112M|MSH5_uc003nwz.3_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	438					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						GCAGTGTCATCTACATCCCTC	0.478			NA						Direct_reversal_of_damage|MMR					7	65					0	0	0.001984	0	0
FKBPL	63943	broad.mit.edu	37	6	32097284	32097284	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:32097284G>A	uc003nzr.2	-	2	544	c.274C>T	c.(274-276)CAA>TAA	p.Q92*	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	92					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						TCAGAAGCTTGAAGGGCCTCT	0.498			NA											6	69					0	0	0.001984	0	0
NOTCH4	4855	broad.mit.edu	37	6	32181887	32181887	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:32181887C>A	uc003obb.2	-	13	2306	c.2167G>T	c.(2167-2169)GGA>TGA	p.G723*	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	723	Extracellular (Potential).|EGF-like 18.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						AGGGTCTCACCTGTGTAGCCT	0.617			NA											29	113					2.80507e-11	3.79088e-11	0.012213	1	0
GPR116	221395	broad.mit.edu	37	6	46826549	46826549	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:46826549G>C	uc003oyo.3	-	17	3380	c.3091C>G	c.(3091-3093)CTA>GTA	p.L1031V	GPR116_uc011dwj.1_Missense_Mutation_p.L586V|GPR116_uc011dwk.1_Missense_Mutation_p.L460V|GPR116_uc003oyp.3_Missense_Mutation_p.L889V|GPR116_uc003oyq.3_Missense_Mutation_p.L1031V|GPR116_uc010jzi.1_Missense_Mutation_p.L703V	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1031	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TCCACAACTAGACAGGCTGCC	0.512	NSCLC(59;410 1274 8751 36715 50546)		NA											5	45					0	0	0.000602	0	0
PKHD1	5314	broad.mit.edu	37	6	51890718	51890718	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:51890718G>A	uc003pah.1	-	32	4166	c.3890C>T	c.(3889-3891)GCG>GTG	p.A1297V	PKHD1_uc003pai.2_Missense_Mutation_p.A1297V	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1297	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGTTGCTGCCGCTTCATACAT	0.542			NA											4	51					0	0	0.000602	0	0
SNAP91	9892	broad.mit.edu	37	6	84371233	84371233	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:84371233C>T	uc011dze.1	-	5	757	c.440G>A	c.(439-441)AGG>AAG	p.R147K	SNAP91_uc003pkb.2_Missense_Mutation_p.R112K|SNAP91_uc003pkc.2_Missense_Mutation_p.R147K|SNAP91_uc003pkd.2_Missense_Mutation_p.R147K|SNAP91_uc003pka.2_Missense_Mutation_p.R147K|SNAP91_uc011dzf.1_Missense_Mutation_p.R28K	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	147					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TTTCTTCACCCTGGCAAAATC	0.348			NA											8	33					0	0	0.006214	0	0
TAAR5	9038	broad.mit.edu	37	6	132910535	132910535	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:132910535C>G	uc003qdk.2	-	1	343	c.291G>C	c.(289-291)GAG>GAC	p.E97D		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	97	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		ACCAGCAGCTCTCCACTGAGC	0.587			NA											8	58					0	0	0.004482	0	0
IL20RA	53832	broad.mit.edu	37	6	137330561	137330561	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:137330561G>T	uc003qhj.2	-	4	905	c.472C>A	c.(472-474)CCA>ACA	p.P158T	IL20RA_uc011edl.1_Missense_Mutation_p.P109T|IL20RA_uc003qhk.2_Missense_Mutation_p.P47T|IL20RA_uc010kgy.1_RNA|IL20RA_uc003qhi.2_5'Flank	NM_014432	NP_055247	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha precursor	158	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	receptor activity			ovary(2)|skin(2)	4	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		CACTTCTCTGGAGCTGTCAGG	0.423			NA											17	68					5.01169e-05	5.71414e-05	0.00499	1	0
TAGAP	117289	broad.mit.edu	37	6	159463125	159463125	+	Silent	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:159463125G>T	uc003qrz.2	-	5	632	c.300C>A	c.(298-300)CTC>CTA	p.L100L	TAGAP_uc011eft.1_Silent_p.L37L|TAGAP_uc003qsa.2_Intron|TAGAP_uc003qsb.2_Silent_p.L100L|uc003qsc.2_5'Flank	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	100	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TGGGTCTGGGGAGTGTGTCAC	0.458			NA											12	181					6.40141e-05	7.25951e-05	0.010729	1	0
FNDC1	84624	broad.mit.edu	37	6	159654341	159654341	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr6:159654341G>T	uc010kjv.2	+	11	2997	c.2797G>T	c.(2797-2799)GGG>TGG	p.G933W	FNDC1_uc010kjw.1_Missense_Mutation_p.G818W	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	933						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAAATCCACAGGGGCAGATAC	0.607			NA											4	23					0.00909568	0.00957083	0.009096	1	0
SUN1	23353	broad.mit.edu	37	7	892283	892283	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:892283A>G	uc011jvp.1	+	9	968	c.889A>G	c.(889-891)ATC>GTC	p.I297V	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Missense_Mutation_p.I214V|SUN1_uc011jvq.1_Missense_Mutation_p.I195V|SUN1_uc003sjg.2_Missense_Mutation_p.I202V|SUN1_uc011jvr.1_Missense_Mutation_p.I106V|SUN1_uc003sji.2_Missense_Mutation_p.I135V|SUN1_uc003sjk.2_5'UTR	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	324	Helical.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						AGTCTTGCTCATCCCACTCTT	0.413			NA											11	178					0	0	0.001368	0	0
FOXK1	221937	broad.mit.edu	37	7	4798715	4798715	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:4798715G>A	uc003snc.1	+	6	1288	c.1278G>A	c.(1276-1278)CTG>CTA	p.L426L	FOXK1_uc003sna.1_Silent_p.L263L	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	426					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		ACCCCGGGCTGATGTCCCCTC	0.672			NA											6	73					0	0	0.001984	0	0
PMS2	5395	broad.mit.edu	37	7	6029467	6029467	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:6029467G>C	uc003spl.2	-	10	1195	c.1108C>G	c.(1108-1110)CTA>GTA	p.L370V	PMS2_uc003spj.2_Missense_Mutation_p.L264V|PMS2_uc003spk.2_Missense_Mutation_p.L235V|PMS2_uc011jwl.1_Missense_Mutation_p.L235V|PMS2_uc010ktg.2_Missense_Mutation_p.L59V|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Missense_Mutation_p.L370V	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	370					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTGACATTTAGCTTGTTGACA	0.353			NA	Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				19	113					0	0	0.012319	0	0
ABCB5	340273	broad.mit.edu	37	7	20698213	20698213	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:20698213C>T	uc003suw.3	+	5	832	c.286C>T	c.(286-288)CGA>TGA	p.R96*	ABCB5_uc010kuh.2_Nonsense_Mutation_p.R541*|ABCB5_uc003suv.3_Nonsense_Mutation_p.R96*|ABCB5_uc011jyi.1_Nonsense_Mutation_p.R96*	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	96	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TGCCTTAGTTCGAAACCCCAA	0.438			NA											6	49					0	0	0.001984	0	0
HOXA1	3198	broad.mit.edu	37	7	27135384	27135384	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:27135384C>G	uc003sye.2	-	1	242	c.148G>C	c.(148-150)GAC>CAC	p.D50H	HOXA1_uc003syd.2_Missense_Mutation_p.D50H|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	50						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						AAGCGGTCGTCGCCGCCGCAA	0.537			NA									OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	60					0	0	0.001984	0	0
NT5C3	51251	broad.mit.edu	37	7	33057107	33057107	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:33057107C>A	uc003tdk.2	-	7	729	c.652G>T	c.(652-654)GGT>TGT	p.G218C	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Missense_Mutation_p.G179C|NT5C3_uc003tdj.2_Missense_Mutation_p.G179C	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	218					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			TGATAAACACCAGCTTGACGA	0.333			NA											25	84					3.01185e-09	3.94431e-09	0.003954	1	0
TBX20	57057	broad.mit.edu	37	7	35242089	35242089	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:35242089T>A	uc011kas.1	-	8	1308	c.1297A>T	c.(1297-1299)ATT>TTT	p.I433F		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	433						nucleus	DNA binding			central_nervous_system(1)	1						AGTCCTTGAATGGCAGCATAG	0.502			NA											3	9					0	0	0.004672	0	0
C7orf36	57002	broad.mit.edu	37	7	39610121	39610121	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:39610121G>C	uc003thc.3	+	2	155	c.146G>C	c.(145-147)GGA>GCA	p.G49A		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	49											0						TATAGAGATGGAATAGATGCT	0.368			NA											16	135					0	0	0.00499	0	0
ADCY1	107	broad.mit.edu	37	7	45650011	45650011	+	Missense_Mutation	SNP	G	G	A	rs80190930		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:45650011G>A	uc003tne.3	+	3	841	c.823G>A	c.(823-825)GTT>ATT	p.V275I	ADCY1_uc003tnd.2_Missense_Mutation_p.V50I	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	275	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCCCGGAACGTTGCCATGGA	0.597			NA											13	133					0	0	0.004007	0	0
PTPN12	5782	broad.mit.edu	37	7	77265123	77265123	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:77265123G>C	uc003ugh.2	+	15	2190	c.2099G>C	c.(2098-2100)AGT>ACT	p.S700T	PTPN12_uc011kgp.1_Missense_Mutation_p.S581T|PTPN12_uc011kgq.1_Missense_Mutation_p.S570T|PTPN12_uc010lds.2_Missense_Mutation_p.S432T	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	700						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						TCGGAATGGAGTGAACTTCAA	0.303			NA											8	29					0	0	0.00308	0	0
STEAP4	79689	broad.mit.edu	37	7	87913242	87913242	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:87913242C>G	uc003ujs.2	-	2	448	c.343G>C	c.(343-345)GAA>CAA	p.E115Q	STEAP4_uc010lek.2_Missense_Mutation_p.E115Q|STEAP4_uc003ujt.2_Missense_Mutation_p.E115Q	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	115					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					GCATTAGATTCTGGATATTGA	0.433			NA											8	126					0	0	0.004482	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965143	88965143	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:88965143C>A	uc011khi.1	+	4	3385	c.2847C>A	c.(2845-2847)AAC>AAA	p.N949K		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	949						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TCTCTTCAAACAGTTGTAAAA	0.403			NA								HNSCC(36;0.09)			49	145					5.2432e-18	7.51822e-18	0.00361	1	0
STEAP1	26872	broad.mit.edu	37	7	89793973	89793973	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:89793973G>A	uc003ujx.2	+	5	1145	c.945G>A	c.(943-945)AAG>AAA	p.K315K	STEAP2_uc003ujy.2_5'Flank	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	315					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					GCTTGAGGAAGAAGATACTGA	0.348			NA											6	71					0	0	0.001168	0	0
GTPBP10	85865	broad.mit.edu	37	7	89984473	89984473	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:89984473C>G	uc003ukm.1	+	4	459	c.393C>G	c.(391-393)TTC>TTG	p.F131L	GTPBP10_uc003uki.1_Missense_Mutation_p.F148L|GTPBP10_uc003ukj.1_Missense_Mutation_p.F122L|GTPBP10_uc003ukk.1_Intron|GTPBP10_uc003ukl.1_RNA|GTPBP10_uc003ukn.1_Intron|GTPBP10_uc003uko.1_Intron	NM_033107	NP_149098	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 isoform 2	131					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding				0						TTACAAATTTCTTACCATTGA	0.328			NA											6	122					0	0	0.001168	0	0
PLOD3	8985	broad.mit.edu	37	7	100850884	100850885	+	Missense_Mutation	DNP	CT	CT	AC			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:100850884_100850885CT>AC	uc003uyd.2	-	17	2365_2366	c.1909_1910AG>GT	c.(1909-1911)AGC>GTC	p.S637V	PLOD3_uc010lhs.2_Missense_Mutation_p.S202V	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	637					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	GGGAAACAGGCTCTCGGTCATG	0.644			NA											6	31					0	0	0.004672	0	0
SPDYE6	729597	broad.mit.edu	37	7	101988909	101988909	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:101988909G>C	uc011kkp.1	-	6	1385	c.964C>G	c.(964-966)CCG>GCG	p.P322A	SPDYE6_uc003uzb.2_Missense_Mutation_p.P178A	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	322	Arg-rich.										0						CTGGCCCTCGGGTTCGTGGAA	0.572			NA											14	356					0	0	0.00278	0	0
NRCAM	4897	broad.mit.edu	37	7	107880462	107880462	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:107880462C>T	uc003vfb.2	-	4	518	c.47G>A	c.(46-48)AGA>AAA	p.R16K	NRCAM_uc003vfc.2_Missense_Mutation_p.R16K|NRCAM_uc011kmk.1_Missense_Mutation_p.R11K|NRCAM_uc003vfd.2_Missense_Mutation_p.R11K|NRCAM_uc003vfe.2_Missense_Mutation_p.R11K	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	16					angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						CAGGGGCACTCTGCCCGCAGA	0.433			NA											13	106					0	0	0.004007	0	0
GPR85	54329	broad.mit.edu	37	7	112723882	112723882	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:112723882C>A	uc010ljv.2	-	2	1412	c.895G>T	c.(895-897)GGC>TGC	p.G299C	GPR85_uc003vgp.1_Missense_Mutation_p.G299C|GPR85_uc003vgq.2_Missense_Mutation_p.G299C|GPR85_uc010ljw.1_Missense_Mutation_p.G299C	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	299	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						AGGTAGGGGCCCCACAAGGTT	0.458			NA											32	64					2.70662e-09	3.55559e-09	0.009535	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117432597	117432597	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:117432597C>T	uc003vjf.2	-	4	745	c.653G>A	c.(652-654)CGA>CAA	p.R218Q		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	218	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TGTGCTTCTTCGTTTCTCAGC	0.478			NA											9	47					0	0	0.004482	0	0
ANKRD7	56311	broad.mit.edu	37	7	117876107	117876107	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:117876107C>T	uc003vji.2	+	4	654	c.481C>T	c.(481-483)CCA>TCA	p.P161S		NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	161	ANK 4.				male gonad development						0						TGGGTATACTCCACTATTAGT	0.274			NA											8	83					0	0	0.00308	0	0
RNF133	168433	broad.mit.edu	37	7	122338097	122338097	+	Silent	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:122338097T>A	uc003vkj.1	-	1	1112	c.876A>T	c.(874-876)ACA>ACT	p.T292T	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	292	RING-type; atypical.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						AAATGGGGCATGTCCCATGGG	0.383	Colon(198;1778 2057 7449 19869 45985)		NA											24	80					0	0	0.00333	0	0
WASL	8976	broad.mit.edu	37	7	123332669	123332669	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:123332669G>A	uc003vkz.2	-	9	1407	c.1079C>T	c.(1078-1080)CCA>CTA	p.P360L		NM_003941	NP_003932	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome gene-like protein	360	Pro-rich.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity				0						TGGAGGTGGTGGTGGAGGCCC	0.667			NA											23	117					0	0	0.002299	0	0
CNOT4	4850	broad.mit.edu	37	7	135080502	135080502	+	Nonsense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:135080502G>C	uc003vsv.1	-	9	1320	c.1013C>G	c.(1012-1014)TCA>TGA	p.S338*	CNOT4_uc003vss.2_Nonsense_Mutation_p.S335*|CNOT4_uc011kpz.1_Nonsense_Mutation_p.S335*|CNOT4_uc003vst.2_Nonsense_Mutation_p.S338*|CNOT4_uc003vsu.1_Nonsense_Mutation_p.S335*|CNOT4_uc011kpy.1_Nonsense_Mutation_p.S338*	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	338					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						AAAATTGTCTGAGAATAACGA	0.517	Ovarian(51;766 1130 5502 35047 50875)		NA											12	66					0	0	0.001368	0	0
TRIM24	8805	broad.mit.edu	37	7	138189108	138189108	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:138189108G>T	uc003vuc.2	+	2	653	c.438G>T	c.(436-438)AAG>AAT	p.K146N	TRIM24_uc003vub.2_Missense_Mutation_p.K146N	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	146					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						TTTTTGTGAAGGACACTACTG	0.373	Pancreas(179;936 2074 16128 47811 50326)|Colon(136;168 1735 9344 12243 52014)		NA											24	133					2.21704e-12	3.04482e-12	0.00278	1	0
SVOPL	136306	broad.mit.edu	37	7	138347839	138347839	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:138347839C>T	uc011kqh.1	-	4	325	c.325G>A	c.(325-327)GAC>AAC	p.D109N	SVOPL_uc003vue.2_5'UTR	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	109						integral to membrane	transmembrane transporter activity				0						CCATATCTGTCAGCCAGGAGG	0.453			NA											6	27					0	0	0.00308	0	0
ZNF786	136051	broad.mit.edu	37	7	148769014	148769014	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:148769014G>C	uc003wfh.2	-	4	987	c.850C>G	c.(850-852)CCC>GCC	p.P284A	ZNF786_uc011kuk.1_Missense_Mutation_p.P247A|ZNF786_uc003wfi.2_Missense_Mutation_p.P198A	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGGTGGCTGGGATGGGTCAGC	0.697			NA											5	31					0	0	0.000602	0	0
SSPO	23145	broad.mit.edu	37	7	149519225	149519225	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr7:149519225C>T	uc010lpk.2	+	91	13029	c.13029C>T	c.(13027-13029)CCC>CCT	p.P4343P	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_RNA|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4343	TSP type-1 21.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGGCCGACCCCACCTGCAACA	0.672			NA											6	54					0	0	0.00308	0	0
BMP1	649	broad.mit.edu	37	8	22067158	22067158	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:22067158G>A	uc003xbg.2	+	19	3020	c.2776G>A	c.(2776-2778)GAC>AAC	p.D926N	BMP1_uc011kzc.1_Missense_Mutation_p.D675N|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	926	CUB 5.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GGAGCTCTTCGACGGCTACGA	0.667			NA											12	101					0	0	0.003163	0	0
CHRNA2	1135	broad.mit.edu	37	8	27328547	27328547	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:27328547G>T	uc010lur.2	-	2	638	c.29C>A	c.(28-30)TCC>TAC	p.S10Y	CHRNA2_uc011lal.1_Missense_Mutation_p.S10Y|CHRNA2_uc010lus.2_5'UTR	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	10						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	CTTTGTGAAGGACAGGAACAC	0.562			NA											5	23					2.0095e-06	2.38769e-06	0.001984	1	0
WRN	7486	broad.mit.edu	37	8	31024633	31024633	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:31024633G>C	uc003xio.3	+	34	4866	c.4078G>C	c.(4078-4080)GAC>CAC	p.D1360H	WRN_uc010lvk.2_Missense_Mutation_p.D827H	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1360					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ACATGGTCCTGACAGCGGACT	0.398	Ovarian(18;161 598 2706 14834 27543)		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				11	73					0	0	0.010729	0	0
PRKDC	5591	broad.mit.edu	37	8	48817449	48817449	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:48817449C>A	uc003xqi.2	-	26	3079	c.3022G>T	c.(3022-3024)GCC>TCC	p.A1008S	PRKDC_uc003xqj.2_Missense_Mutation_p.A1008S|PRKDC_uc011ldh.1_Missense_Mutation_p.A1008S	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1008	HEAT 2.			A -> S (in Ref. 2; AAC50210).	cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TCTAGTAAGGCAACAGTATCC	0.323	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					12	98					2.27111e-07	2.83386e-07	0.001368	1	0
TOX	9760	broad.mit.edu	37	8	59750834	59750834	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:59750834C>A	uc003xtw.1	-	5	951	c.730G>T	c.(730-732)GGG>TGG	p.G244W		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	244	Nuclear localization signal (Potential).					nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GGTTTTTTCCCCATATCAGAG	0.443	Pancreas(161;610 1969 17913 21374 22725)		NA											9	112					2.17888e-05	2.51135e-05	0.006214	1	0
CLVS1	157807	broad.mit.edu	37	8	62212729	62212729	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:62212729G>A	uc003xuh.2	+	2	667	c.343G>A	c.(343-345)GAT>AAT	p.D115N	CLVS1_uc003xug.2_Missense_Mutation_p.D115N|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Missense_Mutation_p.D115N	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	115					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CAAGGCAGATGATCCCGGCAT	0.507			NA											5	51					0	0	0.000602	0	0
CA3	761	broad.mit.edu	37	8	86356314	86356314	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:86356314A>G	uc003ydj.2	+	4	486	c.403A>G	c.(403-405)AAG>GAG	p.K135E	CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	135					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						AGAAGCCCTGAAGCAGCGCGA	0.378			NA											19	58					0	0	0.008871	0	0
RGS22	26166	broad.mit.edu	37	8	100994191	100994191	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:100994191C>T	uc003yjb.1	-	22	3529	c.3334G>A	c.(3334-3336)GGA>AGA	p.G1112R	RGS22_uc003yja.1_Missense_Mutation_p.G931R|RGS22_uc003yjc.1_Missense_Mutation_p.G1100R	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1112	RGS 2.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ACATATGGTCCTAACTCCTTC	0.358			NA											28	289					0	0	0.008361	0	0
RIMS2	9699	broad.mit.edu	37	8	104955058	104955058	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:104955058C>T	uc003yls.2	+	12	2180	c.1939C>T	c.(1939-1941)CAG>TAG	p.Q647*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.Q869*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.Q661*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.Q661*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.Q708*|RIMS2_uc003ylt.2_Nonsense_Mutation_p.Q254*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	931					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTACAAACTTCAGACGCATGA	0.413			NA								HNSCC(12;0.0054)			4	51					0	0	0.000602	0	0
CSMD3	114788	broad.mit.edu	37	8	113484921	113484921	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:113484921C>G	uc003ynu.2	-	32	5453	c.5294G>C	c.(5293-5295)CGT>CCT	p.R1765P	CSMD3_uc003yns.2_Missense_Mutation_p.R1037P|CSMD3_uc003ynt.2_Missense_Mutation_p.R1725P|CSMD3_uc011lhx.1_Missense_Mutation_p.R1661P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1765	Extracellular (Potential).|CUB 10.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACCTGTTGAACGACTTCCACA	0.318			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	59					0	0	0.001855	0	0
ADCY8	114	broad.mit.edu	37	8	132002737	132002737	+	Missense_Mutation	SNP	T	T	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:132002737T>A	uc003ytd.3	-	2	1268	c.1012A>T	c.(1012-1014)ATC>TTC	p.I338F	ADCY8_uc010mds.2_Missense_Mutation_p.I338F	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	338	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGGTAACTGATGAAGATTCCA	0.512			NA								HNSCC(32;0.087)			14	151					0	0	0.004007	0	0
GPAA1	8733	broad.mit.edu	37	8	145140004	145140004	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr8:145140004G>A	uc003zax.2	+	9	1333	c.1223G>A	c.(1222-1224)GGT>GAT	p.G408D		NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	408	Cytoplasmic (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAGCCCGGGGGTGCCCCTGGC	0.592			NA											4	26					0	0	0.000602	0	0
SLC24A2	25769	broad.mit.edu	37	9	19520910	19520910	+	Missense_Mutation	SNP	A	A	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr9:19520910A>G	uc003zoa.1	-	9	1780	c.1718T>C	c.(1717-1719)ATT>ACT	p.I573T	SLC24A2_uc003zob.1_Missense_Mutation_p.I556T	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	573	Helical; (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GATGTCAAAAATGTTGCTTCC	0.507			NA											10	100					0	0	0.010729	0	0
CTSL3	392360	broad.mit.edu	37	9	90387899	90387899	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr9:90387899G>A	uc004apm.1	+	1	70	c.64G>A	c.(64-66)GCC>ACC	p.A22T		NR_027917				RecName: Full=Putative cathepsin L-like protein 3;          Short=Cathepsin L-like protein; AltName: Full=HCTSL-s;											ovary(1)	1						GGCCATGAACGCCTTTGGAGA	0.453			NA											6	54					0	0	0.001984	0	0
FAM22F	54754	broad.mit.edu	37	9	97082700	97082700	+	Silent	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr9:97082700G>T	uc004aup.1	-	5	1179	c.1158C>A	c.(1156-1158)GTC>GTA	p.V386V		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	386	Pro-rich.										0		Acute lymphoblastic leukemia(62;0.136)				TCTCCTCAGGGACCTTGGTCT	0.667			NA											14	50					3.27435e-08	4.15931e-08	0.00245	1	0
KIAA1529	57653	broad.mit.edu	37	9	100092805	100092805	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr9:100092805C>T	uc011lut.1	+	30	3352	c.2579C>T	c.(2578-2580)CCA>CTA	p.P860L	KIAA1529_uc004axe.1_Missense_Mutation_p.P860L|KIAA1529_uc004axg.1_Missense_Mutation_p.P721L|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.P45L|KIAA1529_uc011lus.1_Missense_Mutation_p.P678L|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.P721L|KIAA1529_uc011luv.1_Missense_Mutation_p.P718L	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				AAAAAATCTCCACTGCATGCT	0.463			NA											5	48					0	0	0.001984	0	0
SVEP1	79987	broad.mit.edu	37	9	113198749	113198749	+	Missense_Mutation	SNP	T	T	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr9:113198749T>G	uc010mtz.2	-	28	5012	c.4675A>C	c.(4675-4677)AAA>CAA	p.K1559Q		NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1559	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TCTCCTTTTTTGTCTTGCTCT	0.483			NA											9	39					0	0	0.004482	0	0
TMEM8C	389827	broad.mit.edu	37	9	136380688	136380688	+	Missense_Mutation	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr9:136380688C>G	uc011mdk.1	-	4	441	c.441G>C	c.(439-441)AAG>AAC	p.K147N		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	147						integral to membrane					0						TGTAGACGCTCTTGTCTGGGT	0.597			NA											4	41					0	0	0.001984	0	0
CACNA1B	774	broad.mit.edu	37	9	140880937	140880937	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr9:140880937C>A	uc004cog.2	+	14	1987	c.1842C>A	c.(1840-1842)TTC>TTA	p.F614L	CACNA1B_uc011mfd.1_Missense_Mutation_p.F145L	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	614	Helical; Name=S5 of repeat II; (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GCCTGCTCTTCTTGCTCTTCC	0.622			NA											4	21					1.23904e-05	1.43987e-05	0.000602	1	0
PIR	8544	broad.mit.edu	37	X	15425673	15425673	+	Splice_Site	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:15425673C>A	uc004cwu.2	-	7	804	c.566_splice	c.e7-1	p.G189_splice	PIR_uc004cwv.2_Splice_Site_p.G189_splice	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin						transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					CTTGTCCACCCTGGAAAGGAC	0.358	Ovarian(180;1587 2015 10555 34192 51653)		NA											16	187					1.15088e-07	1.44457e-07	0.004007	1	0
ACE2	59272	broad.mit.edu	37	X	15584413	15584413	+	Missense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:15584413C>T	uc004cxa.1	-	16	2245	c.2077G>A	c.(2077-2079)GAT>AAT	p.D693N	ACE2_uc004cxb.2_Missense_Mutation_p.D693N	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	693	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	GGAATGATATCAGACACATTT	0.363			NA											27	210					0	0	0.004656	0	0
SAT1	6303	broad.mit.edu	37	X	23803931	23803931	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:23803931G>A	uc004dau.2	+	6	668	c.474G>A	c.(472-474)AAG>AAA	p.K158K	SAT1_uc004dav.2_RNA	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1	158	N-acetyltransferase.				angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	GACTGTTCAAGATCGACAAGG	0.423			NA											7	75					0	0	0.00308	0	0
SSX7	280658	broad.mit.edu	37	X	52682477	52682477	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:52682477G>C	uc004dqx.1	-	2	205	c.46C>G	c.(46-48)CAA>GAA	p.Q16E		NM_173358	NP_775494	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)					TCTGGTATTTGAGCACCAGCC	0.567			NA											17	256					0	0	0.012319	0	0
XAGE3	170626	broad.mit.edu	37	X	52893844	52893844	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:52893844C>T	uc004dre.2	-	4	333	c.273G>A	c.(271-273)AAG>AAA	p.K91K	XAGE3_uc004drf.2_Silent_p.K91K	NM_130776	NP_570132	Q8WTP9	GAGD4_HUMAN	XAGE-3 protein	91											0						TTGGCAGAATCTTCCCCTGGT	0.393			NA											7	124					0	0	0.001984	0	0
FGD1	2245	broad.mit.edu	37	X	54482954	54482954	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:54482954G>A	uc004dtg.2	-	9	2417	c.1683C>T	c.(1681-1683)GCC>GCT	p.A561A	FGD1_uc011moi.1_Silent_p.A319A	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	561	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TTTTGCGGATGGCAGCATTCG	0.597			NA											3	30					0	0	0.004672	0	0
TRO	7216	broad.mit.edu	37	X	54949608	54949608	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:54949608G>T	uc004dtq.2	+	3	750	c.643G>T	c.(643-645)GCC>TCC	p.A215S	TRO_uc011moj.1_Missense_Mutation_p.A158S|TRO_uc004dts.2_Missense_Mutation_p.A215S|TRO_uc004dtr.2_Missense_Mutation_p.A215S|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	215					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						TGCAAATAAGGCCATAGCTAG	0.507			NA											4	20					0.00024832	0.000276419	0.009096	1	0
ALAS2	212	broad.mit.edu	37	X	55043989	55043989	+	Silent	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:55043989C>T	uc004dua.3	-	7	1071	c.933G>A	c.(931-933)AAG>AAA	p.K311K	ALAS2_uc004dub.3_Silent_p.K298K|ALAS2_uc004dud.3_Silent_p.K274K	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	311					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	CTAGAAGTTTCTTTAGGTGGT	0.443			NA											9	158					0	0	0.00245	0	0
TAF1	6872	broad.mit.edu	37	X	70598761	70598761	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:70598761G>A	uc004dzu.3	+	8	1288	c.1237G>A	c.(1237-1239)GAT>AAT	p.D413N	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.D434N	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	413	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				TTGGGAGGATGATATCATCTG	0.478			NA											14	186					0	0	0.003163	0	0
ACRC	93953	broad.mit.edu	37	X	70823695	70823695	+	Missense_Mutation	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:70823695G>A	uc004eae.2	+	8	1069	c.568G>A	c.(568-570)GAC>AAC	p.D190N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	190	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GGATGTTCCCGACGACAACAG	0.498			NA											23	233					0	0	0.003954	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649049	75649049	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:75649049G>T	uc004ecm.1	+	1	933	c.726G>T	c.(724-726)GAG>GAT	p.E242D		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	242	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CCGCCACTGAGGGCCTAAGCA	0.726			NA											3	17					0.004672	0.00496547	0.004672	1	0
P2RY10	27334	broad.mit.edu	37	X	78216425	78216425	+	Silent	SNP	C	C	G			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:78216425C>G	uc004ede.2	+	4	777	c.408C>G	c.(406-408)CTC>CTG	p.L136L	P2RY10_uc004edf.2_Silent_p.L136L	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	136	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						TTTTTCTCCTCAAGCCCTTCA	0.517			NA											15	79					0	0	0.003163	0	0
DACH2	117154	broad.mit.edu	37	X	85906102	85906102	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:85906102A>T	uc004eew.2	+	4	874	c.704A>T	c.(703-705)AAC>ATC	p.N235I	DACH2_uc004eex.2_Missense_Mutation_p.N222I|DACH2_uc010nmq.2_Missense_Mutation_p.N101I|DACH2_uc011mra.1_Missense_Mutation_p.N68I|DACH2_uc010nmr.2_Missense_Mutation_p.N16I	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						ATGGCTATGAACACTCTTCAG	0.413			NA											3	30					0	0	0.004672	0	0
GPRASP1	9737	broad.mit.edu	37	X	101910606	101910606	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:101910606C>A	uc004ejj.3	+	5	2566	c.1765C>A	c.(1765-1767)CAG>AAG	p.Q589K	GPRASP1_uc004eji.3_Missense_Mutation_p.Q589K|GPRASP1_uc010nod.2_Missense_Mutation_p.Q589K	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	589	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						GGCTGAAAACCAGACCTATAT	0.507			NA											13	116					1.5842e-08	2.04929e-08	0.001855	1	0
VSIG1	340547	broad.mit.edu	37	X	107315990	107315990	+	Nonsense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:107315990G>T	uc004eno.2	+	4	657	c.496G>T	c.(496-498)GGA>TGA	p.G166*	VSIG1_uc011msk.1_Nonsense_Mutation_p.G202*	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	166	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CTCTGCGCTTGGAACACCTTC	0.473			NA											24	178					2.44723e-14	3.40519e-14	0.004656	1	0
CXorf56	63932	broad.mit.edu	37	X	118678385	118678385	+	Silent	SNP	T	T	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:118678385T>C	uc004erk.1	-	4	400	c.354A>G	c.(352-354)GCA>GCG	p.A118A	CXorf56_uc004erj.1_Silent_p.A69A|CXorf56_uc011mtu.1_Silent_p.A104A	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	118							protein binding				0						ACTTGACTACTGCTCCATCCA	0.458			NA											13	118					0	0	0.003163	0	0
ODZ1	10178	broad.mit.edu	37	X	123526198	123526198	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:123526198C>A	uc004euj.2	-	27	5435	c.5371G>T	c.(5371-5373)GCC>TCC	p.A1791S	ODZ1_uc011muj.1_Missense_Mutation_p.A1797S|ODZ1_uc010nqy.2_Missense_Mutation_p.A1798S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1791	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGTTGTGGGCCTATGAGAAA	0.388			NA											22	115					5.26018e-13	7.24774e-13	0.012319	1	0
ODZ1	10178	broad.mit.edu	37	X	124030091	124030091	+	Splice_Site	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:124030091C>T	uc004euj.2	-	2	282	c.218_splice	c.e2-1	p.E73_splice	ODZ1_uc011muj.1_Splice_Site_p.E73_splice|ODZ1_uc010nqy.2_Splice_Site_p.E73_splice	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3						immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AATTCCATCTCTGAGAAGAAA	0.443			NA											16	138					0	0	0.003163	0	0
UTP14A	10813	broad.mit.edu	37	X	129060313	129060313	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:129060313C>T	uc004euz.2	+	14	2069	c.2041C>T	c.(2041-2043)CAG>TAG	p.Q681*	UTP14A_uc011mup.1_Nonsense_Mutation_p.Q629*|UTP14A_uc011muq.1_Nonsense_Mutation_p.Q627*	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	681					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						AGCTGCTCATCAGGTGAGAGC	0.463			NA											7	94					0	0	0.00308	0	0
OR13H1	347468	broad.mit.edu	37	X	130678286	130678286	+	Missense_Mutation	SNP	A	A	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:130678286A>T	uc011muw.1	+	1	239	c.239A>T	c.(238-240)CAG>CTG	p.Q80L	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					TCCATGCCCCAGGCTTTGGTG	0.478			NA											13	109					0	0	0.001368	0	0
HPRT1	3251	broad.mit.edu	37	X	133609244	133609244	+	Missense_Mutation	SNP	G	G	T			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:133609244G>T	uc004exl.3	+	3	335	c.168G>T	c.(166-168)GAG>GAT	p.E56D	HPRT1_uc010nrs.2_RNA	NM_000194	NP_000185	P00492	HPRT_HUMAN	hypoxanthine phosphoribosyltransferase 1	56					adenine salvage|central nervous system neuron development|cerebral cortex neuron differentiation|cytolysis|dendrite morphogenesis|GMP catabolic process|GMP salvage|grooming behavior|guanine salvage|hypoxanthine salvage|IMP salvage|lymphocyte proliferation|positive regulation of dopamine metabolic process|protein homotetramerization|purine ribonucleoside salvage|response to amphetamine|striatum development	cytosol	guanine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity|magnesium ion binding|nucleotide binding|protein homodimerization activity				0	Acute lymphoblastic leukemia(192;0.000127)				Mercaptopurine(DB01033)|Thioguanine(DB00352)	TGATGAAGGAGATGGGAGGCC	0.393			NA											13	91					3.45872e-05	3.96487e-05	0.004007	1	0
SLC9A6	10479	broad.mit.edu	37	X	135098878	135098878	+	Silent	SNP	G	G	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:135098878G>A	uc004ezj.2	+	10	1291	c.1215G>A	c.(1213-1215)CAG>CAA	p.Q405Q	SLC9A6_uc004ezk.2_Silent_p.Q437Q	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	405	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TCACCTTCCAGAACCATGTCT	0.333			NA											10	86					0	0	0.008291	0	0
ZIC3	7547	broad.mit.edu	37	X	136649310	136649310	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:136649310C>A	uc004fak.2	+	1	965	c.460C>A	c.(460-462)CCC>ACC	p.P154T		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	154					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AGCTGGCATCCCCGAGCCCCC	0.716			NA											5	28					0.00116845	0.00127057	0.001168	1	0
FGF13	2258	broad.mit.edu	37	X	137793040	137793040	+	Missense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:137793040C>A	uc004fam.2	-	1	788	c.126G>T	c.(124-126)AAG>AAT	p.K42N	FGF13_uc004fan.2_Intron|FGF13_uc011mwi.1_Intron|FGF13_uc004faq.2_Intron|FGF13_uc004far.2_Intron|FGF13_uc011mwj.1_Intron|FGF13_uc011mwk.1_Intron|uc004fao.2_5'Flank	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	42					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AGACATTTAACTTGTTTTTGT	0.522			NA											14	141					3.27435e-08	4.15931e-08	0.00245	1	0
FMR1NB	158521	broad.mit.edu	37	X	147063058	147063058	+	Missense_Mutation	SNP	G	G	C	rs149919226		TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:147063058G>C	uc004fcm.2	+	1	210	c.136G>C	c.(136-138)GAG>CAG	p.E46Q		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	46	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTGGATACGAGGCCGCCAT	0.562			NA											4	46					0	0	0.009096	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935329	151935329	+	Nonsense_Mutation	SNP	C	C	A			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:151935329C>A	uc004fgp.2	-	3	1047	c.838G>T	c.(838-840)GAA>TAA	p.E280*		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	280	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TAGCTGGTTTCAACGAGGGCC	0.532			NA											24	158					1.96895e-08	2.52383e-08	0.00278	1	0
GDI1	2664	broad.mit.edu	37	X	153668831	153668831	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:153668831G>C	uc004fli.3	+	6	1039	c.697G>C	c.(697-699)GAG>CAG	p.E233Q	GDI1_uc011mzo.1_3'UTR|GDI1_uc004flj.2_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	233					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGGCTTGGGCGAGCTGCCCCA	0.562			NA											8	84					0	0	0.006214	0	0
PLXNA3	55558	broad.mit.edu	37	X	153689814	153689814	+	Missense_Mutation	SNP	G	G	C			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chrX:153689814G>C	uc004flm.2	+	3	1143	c.970G>C	c.(970-972)GGC>CGC	p.G324R		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	324	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTCTCTCAGGGCCAGAAGAA	0.657			NA											8	126					0	0	0.00308	0	0
DFFA	1676	broad.mit.edu	37	1	10527291	10527291	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:10527291delC	uc001arj.2	-	3	495	c.397delG	c.(397-399)GAAfs	p.E133fs	DFFA_uc001ark.2_Frame_Shift_Del_p.E133fs	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	133					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GACAGATCTTCTTTCAGCTGC	0.537			NA											12	185	---	---	---	---	NA	NA	NA	NA	NA
SELENBP1	8991	broad.mit.edu	37	1	151337134	151337136	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	CCT	CCT	-	-	CCT	CCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:151337134_151337136delCCT	uc001exx.2	-	12	1349_1351	c.1302_1304delAGG	c.(1300-1305)GGAGGG>GGG	p.434_435GG>G	SELENBP1_uc010pcy.1_In_Frame_Del_p.476_477GG>G|SELENBP1_uc001exy.2_In_Frame_Del_p.331_332GG>G|SELENBP1_uc001exz.2_In_Frame_Del_p.331_332GG>G|SELENBP1_uc010pcz.1_In_Frame_Del_p.372_373GG>G|SELENBP1_uc009wms.2_In_Frame_Del_p.270_271GG>G|SELENBP1_uc009wmt.2_In_Frame_Del_p.331_332GG>G|SELENBP1_uc001eya.2_In_Frame_Del_p.370_371GG>G|SELENBP1_uc009wmu.2_3'UTR	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	434_435					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAACTTCAGCCCTCCTTTTACTG	0.591			NA											13	161	---	---	---	---	NA	NA	NA	NA	NA
RYR2	6262	broad.mit.edu	37	1	237777945	237777945	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr1:237777945delG	uc001hyl.1	+	37	5637	c.5517delG	c.(5515-5517)TTGfs	p.L1839fs		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1839	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGAGGACTTGAAGCACATCT	0.507			NA											8	157	---	---	---	---	NA	NA	NA	NA	NA
CHD2	1106	broad.mit.edu	37	15	93540598	93540600	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	ATT	ATT	-	-	ATT	ATT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr15:93540598_93540600delATT	uc002bsp.2	+	30	4425_4427	c.3850_3852delATT	c.(3850-3852)ATTdel	p.I1284del	CHD2_uc002bso.1_In_Frame_Del_p.I1284del	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1284					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CTGGGAGTTAATTAAAACAGACC	0.384			NA											8	110	---	---	---	---	NA	NA	NA	NA	NA
NOTCH3	4854	broad.mit.edu	37	19	15290919	15290919	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:15290919delC	uc002nan.2	-	20	3367	c.3291delG	c.(3289-3291)GGGfs	p.G1097fs	NOTCH3_uc002nao.1_Frame_Shift_Del_p.G1045fs	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1097	Extracellular (Potential).|EGF-like 28.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CACGGCAGGTCCCCCCATGCT	0.652			NA											13	58	---	---	---	---	NA	NA	NA	NA	NA
C5AR1	728	broad.mit.edu	37	19	47823845	47823847	+	In_Frame_Del	DEL	TCG	TCG	-			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	TCG	TCG	-	-	TCG	TCG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr19:47823845_47823847delTCG	uc002pgj.1	+	2	860_862	c.811_813delTCG	c.(811-813)TCGdel	p.S272del		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	272	Extracellular (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CCTGGAGCCATCGTCACCCACCT	0.557			NA											10	83	---	---	---	---	NA	NA	NA	NA	NA
ELMOD2	255520	broad.mit.edu	37	4	141464740	141464752	+	Splice_Site	DEL	TGTGAGTATTAAA	TGTGAGTATTAAA	-			TCGA-73-4658-01A-01D-1753-08	TCGA-73-4658-11A-01D-1753-08	TGTGAGTATTAAA	TGTGAGTATTAAA	-	-	TGTGAGTATTAAA	TGTGAGTATTAAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b11151cf-6976-4812-a77e-1a12f9d1245c	063c2c69-0159-47e9-8b64-06ce8883a64c	g.chr4:141464740_141464752delTGTGAGTATTAAA	uc003iik.2	+	8	828	c.736_splice	c.e8+1	p.C246_splice		NM_153702	NP_714913	Q8IZ81	ELMD2_HUMAN	ELMO/CED-12 domain containing 2						phagocytosis|regulation of defense response to virus|response to virus	cytoskeleton	GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)					TCAGTTTTACTGTGAGTATTAAAATGAGTTAAA	0.3			NA											9	41	---	---	---	---	NA	NA	NA	NA	NA