Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTCHD2	57540	broad.mit.edu	37	1	11595166	11595166	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:11595166C>A	uc001ash.3	+	19	3772	c.3634C>A	c.(3634-3636)CTC>ATC	p.L1212I		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1212	Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GCTGCCCGTGCTCCTCAGCAT	0.687			NA											3	21					0.000602214	0.000619421	0.014758	1	0
MFN2	9927	broad.mit.edu	37	1	12069782	12069782	+	Silent	SNP	A	A	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:12069782A>C	uc001atn.3	+	18	2656	c.2203A>C	c.(2203-2205)AGG>CGG	p.R735R	MFN2_uc009vni.2_Silent_p.R735R	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	735	Cytoplasmic (Potential).|Potential.				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AAAGCTGCTCAGGTGAGGCTG	0.572			NA											4	32					0	0	0.014758	0	0
PDPN	10630	broad.mit.edu	37	1	13940881	13940881	+	Missense_Mutation	SNP	A	A	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:13940881A>G	uc001avd.2	+	5	734	c.685A>G	c.(685-687)ATG>GTG	p.M229V	PDPN_uc001avc.2_Missense_Mutation_p.M229V|PDPN_uc009vob.2_Missense_Mutation_p.M111V|PDPN_uc009voc.2_Missense_Mutation_p.M111V|PDPN_uc001ave.2_Missense_Mutation_p.M111V|PDPN_uc001avf.2_Missense_Mutation_p.M111V	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	153	Cytoplasmic (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CGTTGTGGTTATGCGAAAAAT	0.423			NA											20	96					0	0	0.01892	0	0
HSPG2	3339	broad.mit.edu	37	1	22173972	22173972	+	Missense_Mutation	SNP	T	T	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:22173972T>A	uc001bfj.2	-	62	8079	c.8039A>T	c.(8038-8040)CAC>CTC	p.H2680L	HSPG2_uc009vqd.2_Missense_Mutation_p.H2681L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2680	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CAACCGCAGGTGGGAGCCATG	0.632			NA											38	121					0	0	0.01441	0	0
CYP4A11	1579	broad.mit.edu	37	1	47406939	47406939	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:47406939G>T	uc001cqp.3	-	1	218	c.167C>A	c.(166-168)TCC>TAC	p.S56Y	CYP4A11_uc001cqq.2_Missense_Mutation_p.S56Y|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	56					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GAGCCAGTGGGAGGGAGGGCA	0.597			NA											17	76					1.99824e-07	2.07509e-07	0.00499	1	0
INSL5	10022	broad.mit.edu	37	1	67263711	67263711	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:67263711C>G	uc001dcw.2	-	2	428	c.393G>C	c.(391-393)TTG>TTC	p.L131F		NM_005478	NP_005469	Q9Y5Q6	INSL5_HUMAN	insulin-like 5 precursor	131						extracellular region	hormone activity				0						AAAGAGCACTCAAATCAGTCA	0.403			NA											9	54					0	0	0.008291	0	0
MAN1A2	10905	broad.mit.edu	37	1	117910819	117910819	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:117910819C>T	uc001ehd.1	+	1	735	c.14C>T	c.(13-15)GCC>GTC	p.A5V	MAN1A2_uc009whg.1_5'UTR	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	5	Cytoplasmic (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		ACTACCCCAGCCCTGCTGCCC	0.468	Ovarian(33;199 881 8228 13687 31538)		NA											13	82					0	0	0.020292	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783693	149783693	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:149783693G>A	uc001esr.2	-	1	236	c.186C>T	c.(184-186)ATC>ATT	p.I62I	HIST2H2BF_uc010pbj.1_Silent_p.I62I|HIST2H2BF_uc010pbk.1_Silent_p.I62I	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	62					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					AGGAGTTCATGATGCCCATGG	0.612			NA											7	320					0	0	0.001984	0	0
PRPF3	9129	broad.mit.edu	37	1	150312943	150312943	+	Silent	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:150312943C>G	uc001eum.3	+	9	1434	c.1272C>G	c.(1270-1272)CTC>CTG	p.L424L	PRPF3_uc009wlp.2_RNA|PRPF3_uc010pca.1_Silent_p.L383L|PRPF3_uc010pcb.1_Silent_p.L375L|PRPF3_uc009wlq.1_RNA	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	424					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		CAGCCCAGCTCAATCCTCCAG	0.269	Ovarian(168;1070 2670 5178 20729)		NA											4	95					0	0	0.009096	0	0
FLG	2312	broad.mit.edu	37	1	152276983	152276983	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:152276983G>A	uc001ezu.1	-	3	10415	c.10379C>T	c.(10378-10380)TCA>TTA	p.S3460L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3460	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGGACCCTGAGTGTCCAGA	0.572			NA							Ichthyosis				10	751					0	0	0.004482	0	0
SPTA1	6708	broad.mit.edu	37	1	158627401	158627401	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:158627401G>A	uc001fst.1	-	19	2870	c.2671C>T	c.(2671-2673)CGA>TGA	p.R891*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	891	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATTTTGTCGCCTAGCAGCT	0.463			NA											54	180					0	0	0.01441	0	0
C1orf116	79098	broad.mit.edu	37	1	207196808	207196808	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:207196808T>C	uc001hfd.2	-	4	560	c.301A>G	c.(301-303)ATC>GTC	p.I101V	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	101						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					TGCTGAGTGATGGTCTCCTCT	0.567			NA											14	44					0	0	0.00499	0	0
TLR5	7100	broad.mit.edu	37	1	223285659	223285659	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:223285659T>C	uc001hnv.1	-	4	1161	c.715A>G	c.(715-717)ACA>GCA	p.T239A	TLR5_uc001hnw.1_Missense_Mutation_p.T239A	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	239	Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		ATGTCCACTGTCCAGCCATTT	0.468			NA											3	92					0	0	0.009096	0	0
PCNXL2	80003	broad.mit.edu	37	1	233296064	233296064	+	Missense_Mutation	SNP	A	A	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:233296064A>T	uc001hvl.2	-	19	3717	c.3482T>A	c.(3481-3483)CTC>CAC	p.L1161H	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1161						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TTTGTTTTTGAGAATGGGGTG	0.443			NA											5	49					0	0	0.00308	0	0
RYR2	6262	broad.mit.edu	37	1	237791371	237791371	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:237791371G>A	uc001hyl.1	+	41	6551	c.6431G>A	c.(6430-6432)CGT>CAT	p.R2144H		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2144	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTCATGATTCGTGGATTAGGG	0.408			NA											21	39					0	0	0.021523	0	0
ZNF496	84838	broad.mit.edu	37	1	247464553	247464553	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:247464553C>G	uc001ico.2	-	9	1497	c.1032G>C	c.(1030-1032)GAG>GAC	p.E344D	ZNF496_uc009xgv.2_Missense_Mutation_p.E380D|ZNF496_uc001icp.2_Missense_Mutation_p.E344D	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	344					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E344Q(1)		ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CCAGGCTGTTCTCTAGAGATC	0.617			NA											3	106					0	0	0.004672	0	0
OR2G2	81470	broad.mit.edu	37	1	247752444	247752444	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:247752444G>A	uc010pyy.1	+	1	783	c.783G>A	c.(781-783)ATG>ATA	p.M261I		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	261	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			tcatcttcatgtatctgcagC	0.373			NA											35	99					0	0	0.015359	0	0
OR1C1	26188	broad.mit.edu	37	1	247921555	247921555	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:247921555C>G	uc010pza.1	-	1	154	c.154G>C	c.(154-156)GAC>CAC	p.D52H		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AGGTGAGAGTCAAAGCCAATC	0.473			NA											3	49					0	0	0.004672	0	0
NEBL	10529	broad.mit.edu	37	10	21115407	21115407	+	Missense_Mutation	SNP	C	C	T	rs151035799	byFrequency	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr10:21115407C>T	uc001iqi.2	-	18	2235	c.1838G>A	c.(1837-1839)CGA>CAA	p.R613Q	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	613	Nebulin 17.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TTTCTTCACTCGTTCGATCTC	0.323			NA											5	167					0	0	0.00308	0	0
HERC4	26091	broad.mit.edu	37	10	69684945	69684945	+	Splice_Site	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr10:69684945C>G	uc001jng.3	-	25	3174	c.2863_splice	c.e25-1	p.N955_splice	HERC4_uc009xpq.2_Splice_Site_p.N487_splice|HERC4_uc001jnf.3_Splice_Site|HERC4_uc001jnh.3_Splice_Site_p.N947_splice|HERC4_uc009xpr.2_Splice_Site_p.N877_splice|HERC4_uc001jni.3_Splice_Site_p.N691_splice	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a						cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						ATTCTGTATTCTAAAAACAAC	0.328			NA											11	22					0	0	0.008291	0	0
C10orf90	118611	broad.mit.edu	37	10	128193347	128193347	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr10:128193347G>C	uc001ljq.2	-	3	543	c.422C>G	c.(421-423)ACC>AGC	p.T141S	C10orf90_uc001ljp.2_Missense_Mutation_p.T94S|C10orf90_uc010qum.1_Missense_Mutation_p.T238S|C10orf90_uc009yao.2_Missense_Mutation_p.T238S|C10orf90_uc001ljs.1_Missense_Mutation_p.T94S	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	141										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		GGCCGTGATGGTGATGGATGC	0.677			NA									OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	52					0	0	0.006214	0	0
IGSF22	283284	broad.mit.edu	37	11	18743148	18743148	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr11:18743148G>A	uc009yht.2	-	4	502	c.312C>T	c.(310-312)AGC>AGT	p.S104S	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	104	Ig-like 1.									ovary(4)|large_intestine(2)|kidney(1)	7						TGGGGATGCCGCTCTCCCTCT	0.592			NA									OREG0020822	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	136					0	0	0.014758	0	0
ITGA5	3678	broad.mit.edu	37	12	54797513	54797513	+	Missense_Mutation	SNP	G	G	A	rs143754928	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr12:54797513G>A	uc001sga.2	-	17	1740	c.1672C>T	c.(1672-1674)CGG>TGG	p.R558W		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	558	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						AGTGCCCGCCGTACCCCTCCC	0.547			NA											10	56					0	0	0.00499	0	0
SLC26A10	65012	broad.mit.edu	37	12	58016853	58016853	+	Missense_Mutation	SNP	C	C	G	rs146951916		TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr12:58016853C>G	uc001spe.2	+	7	1297	c.986C>G	c.(985-987)TCT>TGT	p.S329C	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_5'Flank	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	329						integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					TCCCTCTTCTCTTGCTTTCCC	0.537			NA											4	284					0	0	0.014758	0	0
PPFIA2	8499	broad.mit.edu	37	12	81688716	81688716	+	Silent	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr12:81688716T>C	uc001szo.1	-	24	2984	c.2823A>G	c.(2821-2823)AGA>AGG	p.R941R	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	867										ovary(3)|lung(2)|pancreas(1)	6						TTCCAATTTCTCTCTGGATCT	0.493			NA											5	32					0	0	0.014758	0	0
DACT1	51339	broad.mit.edu	37	14	59113480	59113480	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr14:59113480C>T	uc001xdw.2	+	4	2303	c.2139C>T	c.(2137-2139)TAC>TAT	p.Y713Y	DACT1_uc010trv.1_Silent_p.Y432Y|DACT1_uc001xdx.2_Silent_p.Y676Y|DACT1_uc010trw.1_Silent_p.Y432Y	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	713					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CTCTGCCCTACGCCAGCCCCT	0.672			NA											47	40					0	0	0.01441	0	0
DMXL2	23312	broad.mit.edu	37	15	51791717	51791717	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr15:51791717G>T	uc002abf.2	-	18	3929	c.3704C>A	c.(3703-3705)TCT>TAT	p.S1235Y	DMXL2_uc010ufy.1_Missense_Mutation_p.S1235Y|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1235						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CAAGTCTATAGATCTAAGAAG	0.423			NA											7	102					5.4927e-09	5.87339e-09	0.004482	1	0
MAPK6	5597	broad.mit.edu	37	15	52356644	52356644	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr15:52356644G>C	uc002abp.2	+	6	2407	c.1613G>C	c.(1612-1614)AGT>ACT	p.S538T		NM_002748	NP_002739	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	538					cell cycle		ATP binding|MAP kinase activity			lung(3)|ovary(1)	4				all cancers(107;0.0028)		ATTCAGCTTAGTTCCCAGCAT	0.383			NA											10	12					0	0	0.010729	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74368296	74368296	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr15:74368296G>A	uc002axa.1	-	8	636	c.595C>T	c.(595-597)CGG>TGG	p.R199W		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	199	Potential.										0						TGTAACCACCGCTGGAGGACC	0.572			NA											4	97					0	0	0.014758	0	0
SLC6A2	6530	broad.mit.edu	37	16	55719074	55719074	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:55719074C>G	uc002eif.2	+	5	775	c.664C>G	c.(664-666)CAC>GAC	p.H222D	SLC6A2_uc010ccd.2_Missense_Mutation_p.H222D|SLC6A2_uc002eig.2_Missense_Mutation_p.H222D|SLC6A2_uc002eih.2_Missense_Mutation_p.H222D|SLC6A2_uc002eii.2_Missense_Mutation_p.H117D|SLC6A2_uc002eij.2_5'UTR	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	222	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CCTGCACCTTCACGAGAGCAG	0.597			NA											4	37					0	0	0.014758	0	0
NFAT5	10725	broad.mit.edu	37	16	69693761	69693761	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:69693761C>G	uc002exm.1	+	6	2482	c.1274C>G	c.(1273-1275)TCC>TGC	p.S425C	NFAT5_uc002exh.1_Missense_Mutation_p.S219C|NFAT5_uc002exi.2_Missense_Mutation_p.S349C|NFAT5_uc002exj.1_Missense_Mutation_p.S349C|NFAT5_uc002exk.1_Missense_Mutation_p.S349C|NFAT5_uc002exl.1_Missense_Mutation_p.S443C|NFAT5_uc002exn.1_Missense_Mutation_p.S443C	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	425	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AAAGATGGCTCCACTTTGACA	0.388			NA											14	102					0	0	0.007413	0	0
DHX38	9785	broad.mit.edu	37	16	72132853	72132853	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:72132853C>T	uc002fcb.2	+	6	1147	c.792C>T	c.(790-792)GAC>GAT	p.D264D	DHX38_uc010vmp.1_Intron|DHX38_uc010cgn.1_RNA	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	264					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				ACTCGGATGACACGCCTCTGC	0.587	Melanoma(97;711 1442 7855 13832 28836)		NA											5	30					0	0	0.001168	0	0
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	29					0	0	0.01892	0	0
KIAA0100	9703	broad.mit.edu	37	17	26951367	26951367	+	Missense_Mutation	SNP	A	A	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:26951367A>T	uc002hbu.2	-	25	4735	c.4636T>A	c.(4636-4638)TTT>ATT	p.F1546I	KIAA0100_uc002hbt.2_5'Flank	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1546				F -> L (in Ref. 4; CAI45940).		extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AACACTACAAACCTATCTGTC	0.458			NA											23	61					0	0	0.014323	0	0
TADA2A	6871	broad.mit.edu	37	17	35830541	35830541	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:35830541G>A	uc002hnt.2	+	13	1090	c.933G>A	c.(931-933)GAG>GAA	p.E311E	TADA2A_uc002hnv.2_Silent_p.E311E|TADA2A_uc002hnw.2_Silent_p.E210E|TADA2A_uc010cvb.2_Silent_p.E107E	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	311					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						AGACACGGGAGGAAGAGCGCC	0.517			NA											27	149					0	0	0.007291	0	0
MED1	5469	broad.mit.edu	37	17	37565808	37565808	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:37565808C>G	uc002hrv.3	-	17	2878	c.2666G>C	c.(2665-2667)AGT>ACT	p.S889T	MED1_uc010wee.1_Missense_Mutation_p.S717T|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	889	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		ATTATCCCCACTTTGGCTGCT	0.398	Pancreas(21;279 768 2492 4877 24026)		NA								HNSCC(31;0.082)			48	207					0	0	0.01441	0	0
EZH1	2145	broad.mit.edu	37	17	40855782	40855782	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:40855782C>A	uc002iaz.2	-	19	2219	c.2074G>T	c.(2074-2076)GTG>TTG	p.V692L	EZH1_uc002iba.2_Missense_Mutation_p.V683L|EZH1_uc010wgt.1_Missense_Mutation_p.V622L|EZH1_uc010wgu.1_Missense_Mutation_p.V698L|EZH1_uc010wgv.1_Missense_Mutation_p.V652L|EZH1_uc010wgw.1_Missense_Mutation_p.V553L|EZH1_uc010cyp.2_Missense_Mutation_p.V593L|EZH1_uc010cyq.2_Missense_Mutation_p.V609L|EZH1_uc010cyo.1_Missense_Mutation_p.V355L	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	692	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		TTGGGATTCACTGAATGATTT	0.423			NA											10	90					7.03913e-09	7.45319e-09	0.013537	1	0
SLC39A11	201266	broad.mit.edu	37	17	71027795	71027795	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:71027795G>A	uc002jjb.2	-	4	321	c.206C>T	c.(205-207)TCC>TTC	p.S69F	SLC39A11_uc002jja.2_Missense_Mutation_p.S69F|SLC39A11_uc002jjc.1_Missense_Mutation_p.S69F	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	69					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1						GCCCCCAGAGGACGTGGCCAT	0.532	NSCLC(95;736 1527 12296 39625 41839)		NA											25	33					0	0	0.005443	0	0
CARD14	79092	broad.mit.edu	37	17	78171948	78171948	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:78171948G>C	uc002jxw.1	+	12	1840	c.1645G>C	c.(1645-1647)GAT>CAT	p.D549H	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.D549H|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Missense_Mutation_p.D312H	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	549					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGGAAGGCTTGATGTCTCGGA	0.602			NA											3	126					0	0	0.001168	0	0
ZNF844	284391	broad.mit.edu	37	19	12187275	12187275	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:12187275G>C	uc002mtb.2	+	4	1483	c.1340G>C	c.(1339-1341)CGT>CCT	p.R447P	ZNF844_uc010dym.1_Missense_Mutation_p.R290P	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGAAACCGTATGAGTGTA	0.433			NA											3	61					0	0	0.009096	0	0
CYP4F12	66002	broad.mit.edu	37	19	15795668	15795668	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:15795668G>C	uc002nbl.2	+	8	1022	c.961G>C	c.(961-963)GAG>CAG	p.E321Q		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TATAAGAGCAGAGGCTGACAC	0.423			NA											4	73					0	0	0.014758	0	0
BCL3	602	broad.mit.edu	37	19	45262694	45262694	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:45262694C>T	uc010xxe.1	+	9	1257	c.1187C>T	c.(1186-1188)TCC>TTC	p.S396F		NM_005178	NP_005169	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	396	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			ovary(1)|lung(1)	2	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				GGTCTTCTCTCCGCATCACCA	0.388			NA	T	IGH@	CLL 								21	310					0	0	0.004656	0	0
ZNF615	284370	broad.mit.edu	37	19	52496695	52496695	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:52496695C>T	uc002pye.1	-	6	1926	c.1634G>A	c.(1633-1635)TGT>TAT	p.C545Y	ZNF615_uc002pyf.1_Missense_Mutation_p.C556Y|ZNF615_uc002pyg.1_Missense_Mutation_p.C437Y|ZNF615_uc002pyh.1_Missense_Mutation_p.C556Y|ZNF615_uc010epi.1_Missense_Mutation_p.C552Y|ZNF615_uc010ydg.1_Missense_Mutation_p.C550Y	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	545	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCCTTTTCCACACTCATTGCA	0.438			NA											11	94					0	0	0.013537	0	0
BRSK1	84446	broad.mit.edu	37	19	55814114	55814114	+	Missense_Mutation	SNP	C	C	T	rs144130246		TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:55814114C>T	uc002qkg.2	+	10	1184	c.907C>T	c.(907-909)CGG>TGG	p.R303W	BRSK1_uc002qkf.2_Missense_Mutation_p.R319W|BRSK1_uc002qkh.2_5'UTR	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	303			R -> W (in a gastric adenocarcinoma sample; somatic mutation).		establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.R303W(1)		ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCCTGGCCGCCGGGTAGCCAT	0.632			NA											4	49					0	0	0.014758	0	0
C2orf16	84226	broad.mit.edu	37	2	27804634	27804634	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:27804634G>A	uc002rkz.3	+	1	5246	c.5195G>A	c.(5194-5196)AGA>AAA	p.R1732K	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1732	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|13.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CCCTCAGAGAGAAGCCATCAC	0.562			NA											6	249					0	0	0.001168	0	0
FAM98A	25940	broad.mit.edu	37	2	33817255	33817255	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:33817255G>T	uc002rpa.1	-	3	303	c.229C>A	c.(229-231)CTT>ATT	p.L77I	FAM98A_uc010yne.1_5'UTR	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	77								p.L77H(1)		ovary(1)	1	all_hematologic(175;0.115)					CTCACCTCAAGCTGGAATTCT	0.383			NA											7	179					1.06961e-07	1.12154e-07	0.00308	1	0
ALMS1	7840	broad.mit.edu	37	2	73676583	73676583	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:73676583G>A	uc002sje.1	+	10	3043	c.2932G>A	c.(2932-2934)GAA>AAA	p.E978K	ALMS1_uc002sjf.1_Missense_Mutation_p.E934K|ALMS1_uc002sjg.2_Missense_Mutation_p.E364K|ALMS1_uc002sjh.1_Missense_Mutation_p.E364K	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	976	34 X 47 AA approximate tandem repeat.|10.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TCTACCTAGAGAATCTCTGAA	0.463			NA											14	101					0	0	0.006122	0	0
MERTK	10461	broad.mit.edu	37	2	112777075	112777075	+	Missense_Mutation	SNP	G	G	T	rs147779020	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:112777075G>T	uc002thk.1	+	16	2287	c.2165G>T	c.(2164-2166)CGA>CTA	p.R722L	MERTK_uc002thl.1_Missense_Mutation_p.R546L	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	722	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TTTCTTCATCGAGATTTAGCT	0.463			NA											38	48					1.23103e-26	1.37063e-26	0.013114	1	0
NEB	4703	broad.mit.edu	37	2	152363473	152363473	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:152363473C>T	uc010fnx.2	-	135	18594	c.18403G>A	c.(18403-18405)GAC>AAC	p.D6135N	NEB_uc002txr.2_Missense_Mutation_p.D2558N|RIF1_uc002txp.2_Intron|NEB_uc010zca.1_5'Flank|NEB_uc010zcb.1_5'UTR|NEB_uc002txt.3_Missense_Mutation_p.D640N	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6135	Nebulin 168.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTGGCGTGTCTTGAACAACT	0.323			NA											20	32					0	0	0.007291	0	0
CHD6	84181	broad.mit.edu	37	20	40049523	40049523	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr20:40049523C>G	uc002xka.1	-	31	5930	c.5752G>C	c.(5752-5754)GAG>CAG	p.E1918Q		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1918					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTTGCCACCTCTAAGCTTCCT	0.542			NA											4	89					0	0	0.014758	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887961	47887961	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr20:47887961G>C	uc002xui.2	-	3	635	c.388C>G	c.(388-390)CCC>GCC	p.P130A		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	130							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTCTGGTGGGGAGTCCGCCAC	0.527			NA											5	203					0	0	0.001168	0	0
DOPEY2	9980	broad.mit.edu	37	21	37633010	37633010	+	Silent	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr21:37633010T>C	uc002yvg.2	+	24	5374	c.5295T>C	c.(5293-5295)TTT>TTC	p.F1765F	DOPEY2_uc011aeb.1_Silent_p.F1714F|DOPEY2_uc002yvh.2_Silent_p.F616F	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1765					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TGTTGCAGTTTTGCTATGCTT	0.388			NA											63	143					0	0	0.01441	0	0
PRDM15	63977	broad.mit.edu	37	21	43239971	43239971	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr21:43239971C>T	uc002yzq.1	-	25	3436	c.3325G>A	c.(3325-3327)GTC>ATC	p.V1109I	PRDM15_uc002yzo.2_Missense_Mutation_p.V780I|PRDM15_uc002yzp.2_Missense_Mutation_p.V800I|PRDM15_uc002yzr.1_Missense_Mutation_p.V800I	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACTCGCGGACATTGTCGTGC	0.622			NA											20	36					0	0	0.021523	0	0
DMC1	11144	broad.mit.edu	37	22	38934594	38934594	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr22:38934594C>A	uc003avz.1	-	10	785	c.610G>T	c.(610-612)GAT>TAT	p.D204Y	DMC1_uc011anv.1_Missense_Mutation_p.D149Y	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	204					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					GCTACATAATCAAGTAGCTCC	0.363			NA						Homologous_recombination					4	146					0.00909568	0.0092673	0.009096	1	0
CYP2D7P1	1564	broad.mit.edu	37	22	42537252	42537252	+	Silent	SNP	G	G	A	rs2743457	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr22:42537252G>A	uc003bci.2	-	7	1194	c.813C>T	c.(811-813)CAC>CAT	p.H271H	CYP2D7P1_uc003bcg.2_Silent_p.H15H|CYP2D7P1_uc003bch.2_Silent_p.H15H|CYP2D7P1_uc010gyv.2_Silent_p.H55H|CYP2D7P1_uc010gyw.2_RNA|CYP2D7P1_uc010gyx.1_3'UTR	NR_002570				SubName: Full=Cytochrome P450 2D6;          EC=1.14.14.1;												0						GCTGCACCTCGTGAATCACGG	0.587	GBM(91;329 1845 13264 22235)		NA											4	20					0	0	0.004482	0	0
ZNF860	344787	broad.mit.edu	37	3	32032046	32032046	+	Missense_Mutation	SNP	G	G	A	rs143925165	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:32032046G>A	uc011axg.1	+	2	2024	c.1475G>A	c.(1474-1476)CGT>CAT	p.R492H		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	492	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAGACCTTCCGTCACAATTCA	0.403			NA											4	109					0	0	0.014758	0	0
SCN11A	11280	broad.mit.edu	37	3	38908865	38908865	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:38908865G>A	uc011ays.1	-	23	4097	c.3898C>T	c.(3898-3900)CTG>TTG	p.L1300L		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1300	Helical; Name=S6 of repeat III; (By similarity).|III.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAGAGATTCAGAGTGAAGAAT	0.363			NA											17	42					0	0	0.010504	0	0
MST1	4485	broad.mit.edu	37	3	49722464	49722464	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:49722464G>C	uc003cxg.2	-	14	1675	c.1603C>G	c.(1603-1605)CGG>GGG	p.R535G		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	521	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGCACTGCCGGGCAGTCAGT	0.592	GBM(110;181 1524 8005 22865 46297)		NA											3	15					0	0	0.00308	0	0
PROS1	5627	broad.mit.edu	37	3	93617331	93617331	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:93617331C>A	uc003drb.3	-	8	1151	c.810G>T	c.(808-810)AAG>AAT	p.K270N	PROS1_uc010hoo.2_Missense_Mutation_p.K139N|PROS1_uc003dqz.3_Missense_Mutation_p.K139N	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	270	EGF-like 4; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TGAATCCTTTCTTCCCATCAC	0.378			NA											28	61					6.07407e-21	6.69388e-21	0.007291	1	0
MYH15	22989	broad.mit.edu	37	3	108110646	108110646	+	Silent	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:108110646C>G	uc003dxa.1	-	38	5508	c.5451G>C	c.(5449-5451)CTG>CTC	p.L1817L		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1817	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TACTCCCCATCAGGGCCATCT	0.473			NA											5	247					0	0	0.001984	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111766638	111766638	+	Silent	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:111766638G>C	uc010hqb.2	+	5	575	c.405G>C	c.(403-405)CCG>CCC	p.P135P	TMPRSS7_uc011bhr.1_5'UTR	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	261	Extracellular (Potential).|CUB 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						TCCACTACCCGCTGGAGATTT	0.473			NA											11	81					0	0	0.003163	0	0
WDR52	55779	broad.mit.edu	37	3	113115417	113115417	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:113115417G>A	uc003eae.1	-	14	1773	c.1727C>T	c.(1726-1728)GCT>GTT	p.A576V		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	576	WD 7.									central_nervous_system(1)	1						AGTGACACAAGCAGTATGGGG	0.383			NA											6	103					0	0	0.008291	0	0
CCDC37	348807	broad.mit.edu	37	3	126138959	126138959	+	Silent	SNP	A	A	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:126138959A>G	uc003eiu.1	+	11	1068	c.969A>G	c.(967-969)ACA>ACG	p.T323T	CCDC37_uc010hsg.1_Silent_p.T324T	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	323										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		GTCAGGGTACAAAGAAGCCCT	0.647			NA											3	27					0	0	0.004672	0	0
WDR49	151790	broad.mit.edu	37	3	167277997	167277997	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:167277997C>T	uc003fev.1	-	5	812	c.506G>A	c.(505-507)GGG>GAG	p.G169E	WDR49_uc003feu.1_5'UTR|WDR49_uc011bpd.1_Missense_Mutation_p.G222E|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	169	WD 3.									large_intestine(1)|ovary(1)|skin(1)	3						AACAGTAGACCCTGTATCAGA	0.378			NA											11	43					0	0	0.020292	0	0
PLD1	5337	broad.mit.edu	37	3	171394539	171394539	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:171394539G>A	uc003fhs.2	-	18	2197	c.2081C>T	c.(2080-2082)GCA>GTA	p.A694V	PLD1_uc003fht.2_Missense_Mutation_p.A656V|PLD1_uc003fhu.3_5'Flank|PLD1_uc003fhv.1_Missense_Mutation_p.A19V	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	694	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GAAGTGACGTGCCACATCACG	0.532	NSCLC(149;2174 3517 34058)		NA											50	68					0	0	0.01441	0	0
PIK3CA	5290	broad.mit.edu	37	3	178917494	178917495	+	Missense_Mutation	DNP	GC	GC	TG			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:178917494_178917495GC>TG	uc003fjk.2	+	3	526_527	c.369_370GC>TG	c.(367-372)ATGCCA>ATTGCA	p.123_124MP>IA		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	123_124					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.P124T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CTATCGGCATGCCAGTGTGTGA	0.347	Colon(199;1504 1750 3362 26421 31210 32040)		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			34	60					0	0	0.004672	0	0
HRG	3273	broad.mit.edu	37	3	186383964	186383964	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:186383964C>T	uc003fqq.2	+	1	167	c.144C>T	c.(142-144)TTC>TTT	p.F48F		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	48	Cystatin 1.|Interaction with ATP5A1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GCTACCTTTTCCAATTGCTGC	0.532			NA											6	150					0	0	0.00308	0	0
EREG	2069	broad.mit.edu	37	4	75245174	75245174	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr4:75245174T>C	uc003hie.1	+	2	243	c.77T>C	c.(76-78)CTT>CCT	p.L26P	EREG_uc003hid.2_Missense_Mutation_p.L20P	NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	26					angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)			GGTTTCCATCTTCTACAGGCA	0.363			NA											31	146					0	0	0.007835	0	0
PRDM8	56978	broad.mit.edu	37	4	81123237	81123237	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr4:81123237C>T	uc010ijo.2	+	8	1460	c.621C>T	c.(619-621)GGC>GGT	p.G207G	PRDM8_uc003hmb.3_Silent_p.G207G|PRDM8_uc003hmc.3_Silent_p.G207G	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	207	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						gcggcggcggcggtggcaaag	0.383			NA									OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	27					0	0	0.004672	0	0
PRDM9	56979	broad.mit.edu	37	5	23527198	23527198	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:23527198G>A	uc003jgo.2	+	11	2183	c.2001G>A	c.(1999-2001)AGG>AGA	p.R667R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	667	C2H2-type 7.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATGTCTGCAGGGAGTGTGGGC	0.622			NA								HNSCC(3;0.000094)			31	83					0	0	0.01441	0	0
PTGER4	5734	broad.mit.edu	37	5	40692463	40692463	+	Missense_Mutation	SNP	T	T	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:40692463T>G	uc003jlz.2	+	3	2042	c.1450T>G	c.(1450-1452)TCA>GCA	p.S484A		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	484	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						ACTGAACTTATCAGAAAAATG	0.458			NA											35	88					0	0	0.009718	0	0
IL31RA	133396	broad.mit.edu	37	5	55164714	55164714	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:55164714C>T	uc003jql.2	+	3	315	c.250C>T	c.(250-252)CAG>TAG	p.Q84*	IL31RA_uc003jqk.2_Nonsense_Mutation_p.Q84*|IL31RA_uc011cqj.1_Intron|IL31RA_uc003jqm.2_Nonsense_Mutation_p.Q52*|IL31RA_uc003jqn.2_Nonsense_Mutation_p.Q84*|IL31RA_uc010iwa.1_Nonsense_Mutation_p.Q52*|IL31RA_uc003jqo.2_5'UTR	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	52	Extracellular (Potential).|Fibronectin type-III 1.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CAGTTATACCCAGTACACAGT	0.433			NA											13	88					0	0	0.004007	0	0
ALDH7A1	501	broad.mit.edu	37	5	125912887	125912887	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:125912887C>T	uc003ktx.2	-	6	726	c.534G>A	c.(532-534)CTG>CTA	p.L178L	ALDH7A1_uc003kty.2_RNA|ALDH7A1_uc011cxa.1_Silent_p.L205L|ALDH7A1_uc003ktz.2_Silent_p.L205L	NM_001182	NP_001173	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	178					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	ACTGCTCAATCAGTGCATGGC	0.463			NA											7	45					0	0	0.001984	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530708	140530708	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:140530708C>A	uc003lir.2	+	1	870	c.870C>A	c.(868-870)TTC>TTA	p.F290L	PCDHB6_uc011dah.1_Missense_Mutation_p.F154L	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	290	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCAACCCTTCGAAATAAACG	0.458			NA											26	46					2.61193e-14	2.82089e-14	0.009535	1	0
PCDH12	51294	broad.mit.edu	37	5	141336054	141336054	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:141336054C>T	uc003llx.2	-	1	2574	c.1363G>A	c.(1363-1365)GAC>AAC	p.D455N		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	455	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCATTGTCGTTGATGTCA	0.483			NA											6	138					0	0	0.001168	0	0
CDHR2	54825	broad.mit.edu	37	5	176022672	176022672	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:176022672G>A	uc003mem.1	+	32	3998	c.3932G>A	c.(3931-3933)TGA>TAA	p.*1311*	CDHR2_uc003men.1_Silent_p.*1311*	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	1311					homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						ACGGACCTGTGACAGGGGCCC	0.622			NA											5	146					0	0	0.00308	0	0
HK3	3101	broad.mit.edu	37	5	176317899	176317899	+	Missense_Mutation	SNP	G	G	A	rs113978418	byFrequency	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:176317899G>A	uc003mfa.2	-	5	550	c.458C>T	c.(457-459)GCG>GTG	p.A153V	HK3_uc003mez.2_5'Flank	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	153	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACAGGCTGCGCATCCAGGAA	0.597			NA											26	74					0	0	0.00632	0	0
PROP1	5626	broad.mit.edu	37	5	177419761	177419761	+	Silent	SNP	T	T	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:177419761T>G	uc003mif.1	-	3	939	c.630A>C	c.(628-630)CCA>CCC	p.P210P		NM_006261	NP_006252	O75360	PROP1_HUMAN	PROP paired-like homeobox 1	210					central nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGGAGGGGGTGGGGGGCAGG	0.637			NA											6	49					0	0	0.016723	0	0
C6orf204	387119	broad.mit.edu	37	6	118832571	118832571	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr6:118832571G>C	uc003pxz.1	-	5	1735	c.1147C>G	c.(1147-1149)CAA>GAA	p.Q383E	C6orf204_uc003pya.1_Missense_Mutation_p.Q386E|C6orf204_uc003pyb.2_Missense_Mutation_p.Q383E|C6orf204_uc011ebj.1_Missense_Mutation_p.Q281E|C6orf204_uc003pyc.2_Missense_Mutation_p.Q386E	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	383						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		GTAATTTGTTGCTTCTGCCTG	0.353			NA											13	18					0	0	0.003163	0	0
SNX13	23161	broad.mit.edu	37	7	17838335	17838335	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr7:17838335C>G	uc003stw.1	-	24	2737	c.2524G>C	c.(2524-2526)GCC>CCC	p.A842P	SNX13_uc003stv.2_Missense_Mutation_p.A831P|SNX13_uc010kuc.2_Missense_Mutation_p.A628P|SNX13_uc010kub.2_Missense_Mutation_p.A237P			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	842					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					ACTGAGTCGGCTACTTGTTCA	0.333			NA											6	13					0	0	0.004482	0	0
CAMK2B	816	broad.mit.edu	37	7	44274242	44274242	+	Missense_Mutation	SNP	A	A	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr7:44274242A>T	uc003tkq.2	-	14	1265	c.1055T>A	c.(1054-1056)GTC>GAC	p.V352D	CAMK2B_uc003tkp.2_Missense_Mutation_p.V352D|CAMK2B_uc003tkx.2_Missense_Mutation_p.V327D|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.V328D|CAMK2B_uc003tks.2_Missense_Mutation_p.V327D|CAMK2B_uc003tku.2_Missense_Mutation_p.V328D|CAMK2B_uc003tkv.2_Missense_Mutation_p.V328D|CAMK2B_uc003tkt.2_Missense_Mutation_p.V352D|CAMK2B_uc003tkw.2_Intron|CAMK2B_uc010kyc.2_Missense_Mutation_p.V352D	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	352					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CCTCACCTTGACTCCATCTGC	0.647			NA											14	28					0	0	0.00499	0	0
MUC17	140453	broad.mit.edu	37	7	100686290	100686290	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr7:100686290C>T	uc003uxp.1	+	3	11646	c.11593C>T	c.(11593-11595)CGT>TGT	p.R3865C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3865	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTACCATACGTATTTCAAT	0.493			NA											19	133					0	0	0.006122	0	0
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	A	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507			NA											5	27					0	0	0.008361	0	0
TRIM35	23087	broad.mit.edu	37	8	27145561	27145561	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:27145561G>A	uc003xfl.1	-	6	1070	c.988C>T	c.(988-990)CGC>TGC	p.R330C	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	330	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		ACCTGCACGCGGTAGCCATGG	0.657			NA											3	57					0	0	0.004672	0	0
KCNB2	9312	broad.mit.edu	37	8	73848794	73848794	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:73848794T>C	uc003xzb.2	+	3	1792	c.1204T>C	c.(1204-1206)TGT>CGT	p.C402R		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	402	Helical; Name=Segment S6; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AGGTCTGTGCTGTATTGCTGG	0.433			NA											23	96					0	0	0.010818	0	0
TTC35	9694	broad.mit.edu	37	8	109491251	109491251	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:109491251C>T	uc003ymw.1	+	10	754	c.719C>T	c.(718-720)GCT>GTT	p.A240V		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	240						endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)			AGTCATATTGCTTCTAATCCA	0.328			NA											13	56					0	0	0.020292	0	0
SCRIB	23513	broad.mit.edu	37	8	144892864	144892864	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:144892864C>G	uc003yzp.1	-	12	1403	c.1396G>C	c.(1396-1398)GAG>CAG	p.E466Q	SCRIB_uc003yzo.1_Missense_Mutation_p.E466Q	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	466	Potential.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			ACCCGCTTCTCAGCTGCAGCT	0.647	Pancreas(51;966 1133 10533 14576 29674)		NA											15	273					0	0	0.004007	0	0
UBAP2	55833	broad.mit.edu	37	9	33988994	33988994	+	Missense_Mutation	SNP	C	C	T	rs112150520	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:33988994C>T	uc003ztq.1	-	5	532	c.419G>A	c.(418-420)AGA>AAA	p.R140K	UBAP2_uc011loc.1_Missense_Mutation_p.R102K|UBAP2_uc011lod.1_5'UTR|UBAP2_uc011loe.1_Intron|UBAP2_uc011lof.1_Missense_Mutation_p.R65K|UBAP2_uc011log.1_Missense_Mutation_p.R139K|UBAP2_uc003ztr.2_Missense_Mutation_p.R65K	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	140										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		ATTGCCGCCTCTTCCTTTCCG	0.323			NA											9	139					0	0	0.016723	0	0
PAPPA	5069	broad.mit.edu	37	9	118950344	118950344	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:118950344C>A	uc004bjn.2	+	2	1708	c.1327C>A	c.(1327-1329)CTG>ATG	p.L443M	PAPPA_uc011lxp.1_Missense_Mutation_p.L236M|PAPPA_uc011lxq.1_Missense_Mutation_p.L236M	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	443	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TTGCCGCCACCTGCGCCACCC	0.587			NA											26	77					3.65163e-15	3.98359e-15	0.00632	1	0
ASTN2	23245	broad.mit.edu	37	9	119903720	119903720	+	Silent	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:119903720C>G	uc004bjs.1	-	4	1154	c.1053G>C	c.(1051-1053)CTG>CTC	p.L351L	ASTN2_uc004bjr.1_Silent_p.L351L|ASTN2_uc004bjt.1_Intron	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	351	Cytoplasmic (Potential).					integral to membrane		p.G351G(1)		skin(4)|ovary(3)|breast(1)|kidney(1)	9						ACTTCTGCATCAGGGACTCCA	0.592			NA											24	74					0	0	0.004656	0	0
OR1K1	392392	broad.mit.edu	37	9	125563288	125563288	+	Missense_Mutation	SNP	G	G	A	rs138952318		TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:125563288G>A	uc011lze.1	+	1	887	c.887G>A	c.(886-888)CGC>CAC	p.R296H		NM_080859	NP_543135	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTCTGGAATCGCGATGTACAG	0.602			NA											30	108					0	0	0.013726	0	0
GAPVD1	26130	broad.mit.edu	37	9	128088766	128088766	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:128088766G>A	uc010mwx.2	+	12	2256	c.1930G>A	c.(1930-1932)GAT>AAT	p.D644N	GAPVD1_uc011lzs.1_Missense_Mutation_p.D644N|GAPVD1_uc004bpp.2_Missense_Mutation_p.D644N|GAPVD1_uc004bpq.2_Missense_Mutation_p.D644N|GAPVD1_uc004bpr.2_Missense_Mutation_p.D623N|GAPVD1_uc004bps.2_Missense_Mutation_p.D644N|GAPVD1_uc010mwy.1_Missense_Mutation_p.D503N	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	644					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						ATTAACAGATGATAGGGACAT	0.378			NA											4	143					0	0	0.001984	0	0
PBX3	5090	broad.mit.edu	37	9	128691974	128691974	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:128691974G>T	uc004bqb.2	+	4	673	c.557G>T	c.(556-558)CGA>CTA	p.R186L	PBX3_uc004bqc.2_Missense_Mutation_p.R5L|PBX3_uc004bqd.2_Missense_Mutation_p.R5L|PBX3_uc011lzw.1_Missense_Mutation_p.R111L|PBX3_uc011lzx.1_Missense_Mutation_p.R97L|PBX3_uc004bqe.2_Missense_Mutation_p.R73L	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	186					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						AACCTTCTCCGAGAACAGAGT	0.383			NA											32	92					2.54651e-27	2.86482e-27	0.006999	1	0
RALGDS	5900	broad.mit.edu	37	9	135982592	135982592	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:135982592G>A	uc004cco.2	-	7	1313	c.1293C>T	c.(1291-1293)CGC>CGT	p.R431R	RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Silent_p.R419R|RALGDS_uc004ccr.2_Silent_p.R430R|RALGDS_uc011mcv.1_Silent_p.R402R|RALGDS_uc004ccs.2_Silent_p.R376R|RALGDS_uc011mcw.1_Silent_p.R502R|RALGDS_uc004ccv.1_Silent_p.R200R|RALGDS_uc004ccu.1_Silent_p.R200R	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	431	Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TGACAGTGGCGCGGATGGTGG	0.632	Melanoma(189;762 2088 15384 21931 52515)		NA	T	CIITA	PMBL|Hodgkin Lymphona|								4	122					0	0	0.001168	0	0
QSOX2	169714	broad.mit.edu	37	9	139100646	139100646	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:139100646G>A	uc010nbi.2	-	12	2063	c.2025C>T	c.(2023-2025)CTC>CTT	p.L675L		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	675	Helical; (Potential).				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		ACATCACCATGAGGAACAGGG	0.632			NA											4	178					0	0	0.009096	0	0
TBC1D25	4943	broad.mit.edu	37	X	48419138	48419138	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chrX:48419138G>A	uc004dka.1	+	6	1953	c.1842G>A	c.(1840-1842)GGG>GGA	p.G614G	TBC1D25_uc011mly.1_Silent_p.G556G|TBC1D25_uc004dkb.1_Silent_p.G360G|TBC1D25_uc011mlz.1_Silent_p.G360G|TBC1D25_uc011mma.1_Silent_p.G360G|TBC1D25_uc004dkc.1_Silent_p.G360G|TBC1D25_uc011mmb.1_Silent_p.G618G|TBC1D25_uc011mmc.1_Silent_p.G360G|TBC1D25_uc011mmd.1_Silent_p.G360G	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	614						intracellular	Rab GTPase activator activity			ovary(1)	1						TTGGCCGGGGGAACCCATTCA	0.602			NA											8	111					0	0	0.008291	0	0
PGAM4	441531	broad.mit.edu	37	X	77224607	77224607	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chrX:77224607C>G	uc004ecy.1	-	1	529	c.529G>C	c.(529-531)GAG>CAG	p.E177Q	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	177					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CGTTTCCCCTCCTTGATCTGG	0.517			NA											10	87					0	0	0.010729	0	0
MAGEA12	4111	broad.mit.edu	37	X	151899930	151899930	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chrX:151899930G>C	uc010ntp.2	-	3	1225	c.871C>G	c.(871-873)CTA>GTA	p.L291V	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.L291V	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	291	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTGATCTTTAGCAAATGGTGC	0.562			NA											22	313					0	0	0.00632	0	0
EXO1	9156	broad.mit.edu	37	1	242035540	242035540	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:242035540delG	uc001hzh.2	+	12	2014	c.1474delG	c.(1474-1476)GAAfs	p.E492fs	EXO1_uc001hzi.2_Frame_Shift_Del_p.E492fs|EXO1_uc001hzj.2_Frame_Shift_Del_p.E492fs|EXO1_uc009xgq.2_Frame_Shift_Del_p.E491fs	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	492					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			AAGGAAAAATGAAGAAAGTGG	0.388			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					44	182	---	---	---	---	NA	NA	NA	NA	NA
MMP2	4313	broad.mit.edu	37	16	55513411	55513411	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:55513411delG	uc002ehz.3	+	1	331	c.20delG	c.(19-21)CGGfs	p.R7fs	MMP2_uc010vhd.1_5'Flank|MMP2_uc010ccc.2_5'Flank	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	7					angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CTAATGGCCCGGGGCGCGCTC	0.751			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MARK4	57787	broad.mit.edu	37	19	45801106	45801106	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:45801106delC	uc002pbb.1	+	15	1776	c.1771delC	c.(1771-1773)CCCfs	p.P591fs	MARK4_uc002pba.1_Frame_Shift_Del_p.P591fs			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	591					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GCAGAATGGGCCCCCTGCCTC	0.602			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA