Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZMYM6	9204	broad.mit.edu	37	1	35476084	35476084	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:35476084G>A	uc001byh.2	-	10	1684	c.1456C>T	c.(1456-1458)CGA>TGA	p.R486*	ZMYM6_uc001byf.1_Nonsense_Mutation_p.R486*|ZMYM6_uc010oht.1_Nonsense_Mutation_p.R389*|ZMYM6_uc009vup.2_Nonsense_Mutation_p.R292*|ZMYM6_uc009vuq.1_Nonsense_Mutation_p.R486*|ZMYM6_uc009vur.1_Nonsense_Mutation_p.R292*	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	486					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				CCTGAGAATCGCACAGTCTCC	0.373			NA											7	126					0	0	0.038147	0	0
RLF	6018	broad.mit.edu	37	1	40703541	40703541	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:40703541C>G	uc001cfc.3	+	8	3198	c.3167C>G	c.(3166-3168)ACA>AGA	p.T1056R	RLF_uc001cfd.3_Missense_Mutation_p.T747R	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1056					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGGCCCTGTACAGAGGATACC	0.398			NA											7	70					0	0	0.038147	0	0
TNNT2	7139	broad.mit.edu	37	1	201333427	201333427	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:201333427G>C	uc001gwf.2	-	11	557	c.488C>G	c.(487-489)GCT>GGT	p.A163G	TNNT2_uc009wzn.2_5'Flank|TNNT2_uc009wzo.2_5'Flank|TNNT2_uc009wzp.2_5'Flank|TNNT2_uc001gwg.2_Missense_Mutation_p.A153G|TNNT2_uc001gwh.2_Missense_Mutation_p.A148G|TNNT2_uc001gwi.2_Missense_Mutation_p.A123G|TNNT2_uc009wzr.2_Missense_Mutation_p.A94G|TNNT2_uc001gwj.1_5'Flank|TNNT2_uc009wzs.1_Missense_Mutation_p.A128G|TNNT2_uc001gwk.1_Missense_Mutation_p.A94G|TNNT2_uc009wzt.1_Missense_Mutation_p.A153G	NM_000364	NP_000355	P45379	TNNT2_HUMAN	troponin T type 2, cardiac isoform 1	163					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding				0						GTCACTCACAGCCAGGCGGTT	0.637			NA											2	7					0	0	0.004672	0	0
ZNF678	339500	broad.mit.edu	37	1	227843479	227843479	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:227843479A>C	uc001hqw.1	+	4	1873	c.1528A>C	c.(1528-1530)ATT>CTT	p.I510L	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	565					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				GTATAAGAGAATTTATACTGG	0.323			NA											6	41					0	0	0.038147	0	0
ZNF33A	7581	broad.mit.edu	37	10	38345409	38345409	+	Missense_Mutation	SNP	A	A	G	rs71491230	byFrequency	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr10:38345409A>G	uc001izh.2	+	5	2532	c.2354A>G	c.(2353-2355)CAG>CGG	p.Q785R	ZNF33A_uc001izg.2_Missense_Mutation_p.Q786R|ZNF33A_uc010qev.1_Missense_Mutation_p.Q792R|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	785						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						AGAAATTTCCAGCCACAAGTC	0.383			NA											4	75					0	0	0.009096	0	0
SFTPA2	729238	broad.mit.edu	37	10	81319085	81319085	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr10:81319085C>T	uc001kal.3	-	3	252	c.155G>A	c.(154-156)GGA>GAA	p.G52E	SFTPA2_uc001kan.3_Missense_Mutation_p.G52E|SFTPA2_uc001kam.2_RNA	NM_006926	NP_008857	Q8IWL1	SFPA2_HUMAN	RecName: Full=Pulmonary surfactant-associated protein A2;          Short=SP-A2;          Short=SP-A;          Short=PSP-A;          Short=PSPA; AltName: Full=Alveolar proteinosis protein; AltName: Full=35 kDa pulmonary surfactant-associated protein; Flags: Precursor;	52	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GCCAGGGTCTCCTTTGACACC	0.632			NA							Pulmonary_Fibrosis_Idiopathic				5	77					0	0	0.021553	0	0
PSTK	118672	broad.mit.edu	37	10	124742438	124742438	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr10:124742438C>G	uc001lgy.1	+	2	846	c.406C>G	c.(406-408)CTC>GTC	p.L136V		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	136							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		GTCTTGCTACCTCTTAACAAA	0.403			NA											13	123					0	0	0.028581	0	0
OR51B5	282763	broad.mit.edu	37	11	5363849	5363849	+	Silent	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:5363849A>G	uc001map.1	-	1	906	c.906T>C	c.(904-906)CTT>CTC	p.L302L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAAAAAGGTGAAGAATGGCAT	0.378			NA											8	75					0	0	0.038147	0	0
KIAA0652	9776	broad.mit.edu	37	11	46686502	46686502	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:46686502C>T	uc009yld.2	+	12	1577	c.893C>T	c.(892-894)CCT>CTT	p.P298L	KIAA0652_uc001nda.2_Missense_Mutation_p.P331L|KIAA0652_uc001ndb.2_Missense_Mutation_p.P298L|KIAA0652_uc001ncz.2_Intron|KIAA0652_uc001ndc.2_Intron|KIAA0652_uc010rgv.1_Intron	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	298					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)		GCTACACACCCTCACCAGGTA	0.542			NA											8	153					0	0	0.038147	0	0
ZBTB3	79842	broad.mit.edu	37	11	62519814	62519814	+	Silent	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:62519814G>A	uc001nuz.2	-	2	1595	c.1473C>T	c.(1471-1473)GCC>GCT	p.A491A		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	491	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						TGTGCACCGTGGCATGTCGCC	0.567			NA											4	34					0	0	0.014758	0	0
DDX12	440081	broad.mit.edu	37	12	9573223	9573223	+	Missense_Mutation	SNP	C	C	A	rs4763936	by1000genomes	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:9573223C>A	uc010sgs.1	-	21	2285	c.2090G>T	c.(2089-2091)GGT>GTT	p.G697V	DDX12_uc001qvx.3_5'Flank|DDX12_uc001qvy.1_5'Flank	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						AGAAACCACACCGCACAGGTT	0.478			NA											6	22					0.00198382	0.00212969	0.02938	1	0
DENND5B	160518	broad.mit.edu	37	12	31566417	31566417	+	Silent	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:31566417G>T	uc001rki.1	-	13	2820	c.2634C>A	c.(2632-2634)CTC>CTA	p.L878L	DENND5B_uc001rkh.1_Silent_p.L913L|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	878	RUN 1.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GCTGGGACAAGAGCTTCTTTT	0.403			NA											6	67					0.00198382	0.00212969	0.02938	1	0
OR6C68	403284	broad.mit.edu	37	12	55886450	55886450	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:55886450A>G	uc010spo.1	+	1	304	c.304A>G	c.(304-306)ATT>GTT	p.I102V		NM_001005519	NP_001005519	A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C,	97	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGCATGTGTCATTCAGCTATT	0.358			NA											7	146					0	0	0.038147	0	0
RBMS2	5939	broad.mit.edu	37	12	56975221	56975221	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:56975221G>A	uc001sln.2	+	7	860	c.661G>A	c.(661-663)GGG>AGG	p.G221R	RBMS2_uc010sqp.1_Missense_Mutation_p.G76R|RBMS2_uc010sqq.1_Missense_Mutation_p.G96R|RBMS2_uc009zou.2_5'UTR	NM_002898	NP_002889	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting	221					RNA processing	nucleus	nucleotide binding|RNA binding				0						TGCTGATGGCGGGCCAAAGAA	0.537			NA											3	32					0	0	0.004672	0	0
NTN4	59277	broad.mit.edu	37	12	96059736	96059736	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:96059736A>G	uc001tei.2	-	9	2049	c.1600T>C	c.(1600-1602)TCA>CCA	p.S534P	NTN4_uc009ztf.2_Missense_Mutation_p.S511P|NTN4_uc009ztg.2_Missense_Mutation_p.S497P	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	534	NTR.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TCATGAGCTGATAAAATCTTT	0.303			NA											6	60					0	0	0.02938	0	0
C13orf26	122046	broad.mit.edu	37	13	31540436	31540436	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr13:31540436C>T	uc001uti.2	+	5	566	c.547C>T	c.(547-549)CGA>TGA	p.R183*		NM_152325	NP_689538	Q8N6G2	CM026_HUMAN	hypothetical protein LOC122046	183								p.R183*(1)		ovary(2)|skin(1)	3		Lung SC(185;0.0281)		all cancers(112;0.0176)|Epithelial(112;0.0768)|OV - Ovarian serous cystadenocarcinoma(117;0.0852)		CACTGAATTCCGAAGGAATTA	0.423			NA											7	54					0	0	0.02938	0	0
TMEM90A	646658	broad.mit.edu	37	14	74876105	74876105	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr14:74876105C>G	uc001xpx.2	-	2	591	c.343G>C	c.(343-345)GTC>CTC	p.V115L		NM_001105579	NP_001099049	A6NDD5	SYN1L_HUMAN	transmembrane protein 90A	115					response to biotic stimulus	Golgi apparatus|integral to membrane					0				BRCA - Breast invasive adenocarcinoma(234;0.00159)		TGGATGGTGACATTCTCTGCA	0.597			NA											16	114					0	0	0.024245	0	0
CASC5	57082	broad.mit.edu	37	15	40913729	40913729	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr15:40913729C>G	uc010bbs.1	+	11	1506	c.1345C>G	c.(1345-1347)CAA>GAA	p.Q449E	CASC5_uc010ucq.1_Missense_Mutation_p.Q273E|CASC5_uc001zme.2_Missense_Mutation_p.Q423E|CASC5_uc010bbt.1_Missense_Mutation_p.Q423E	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	449	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TCCATCTATTCAAGGTTGTAA	0.363			NA											10	153					0	0	0.069234	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365563	30365563	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr16:30365563C>A	uc002dxr.2	-	2	412	c.159G>T	c.(157-159)GAG>GAT	p.E53D	CD2BP2_uc002dxs.2_Missense_Mutation_p.E53D	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	53					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						CATCATCATCCTCCTCCTCAT	0.517			NA											41	205					6.2361e-21	7.34251e-21	0.09836	1	0
NGFR	4804	broad.mit.edu	37	17	47587854	47587854	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr17:47587854G>T	uc002ioz.3	+	4	774	c.649G>T	c.(649-651)GCA>TCA	p.A217S		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	217	Ser/Thr-rich.|Extracellular (Potential).				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GGAGCCTGAGGCACCTCCAGA	0.642			NA											5	43					0.00116845	0.00129237	0.021553	1	0
DLGAP1	9229	broad.mit.edu	37	18	3567562	3567562	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr18:3567562T>A	uc002kmf.2	-	6	2050	c.1983A>T	c.(1981-1983)GAA>GAT	p.E661D	DLGAP1_uc010wyz.1_Missense_Mutation_p.E661D|DLGAP1_uc002kme.1_Missense_Mutation_p.E359D|DLGAP1_uc010dkn.2_Missense_Mutation_p.E369D|DLGAP1_uc010wyw.1_Missense_Mutation_p.E367D|DLGAP1_uc010wyx.1_Missense_Mutation_p.E383D|DLGAP1_uc010wyy.1_Missense_Mutation_p.E345D|DLGAP1_uc002kmg.2_Missense_Mutation_p.E359D	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	661	Interaction with DYL2 (By similarity).				synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				TTTTGTCAGGTTCTTCAGCAT	0.403			NA											10	94					0	0	0.080935	0	0
ZNF229	7772	broad.mit.edu	37	19	44933924	44933924	+	Silent	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:44933924C>G	uc002oze.1	-	6	1466	c.1032G>C	c.(1030-1032)GTG>GTC	p.V344V	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Silent_p.V338V	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				GCATGTCTCCCACAGGGGCTC	0.498			NA											6	82					0	0	0.021553	0	0
ZNF766	90321	broad.mit.edu	37	19	52794138	52794138	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:52794138G>A	uc002pyr.1	+	4	1137	c.1094G>A	c.(1093-1095)AGG>AAG	p.R365K	ZNF766_uc002pys.1_3'UTR|ZNF766_uc002pyt.1_Missense_Mutation_p.R380K	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	365	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		AAAGCTTTTAGGCACAAGTTC	0.393			NA											5	21					0	0	0.014758	0	0
ZNF347	84671	broad.mit.edu	37	19	53644080	53644080	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:53644080G>C	uc002qbb.1	-	5	2070	c.2001C>G	c.(1999-2001)CAC>CAG	p.H667Q	ZNF347_uc010eql.1_Missense_Mutation_p.H668Q|ZNF347_uc002qbc.1_Missense_Mutation_p.H668Q	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	667	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		GTCTTGCAAGGTGTGAATTCT	0.413	Melanoma(64;205 1597 17324 45721)		NA											17	140					0	0	0.043863	0	0
ZNF544	27300	broad.mit.edu	37	19	58757682	58757682	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:58757682G>A	uc010euo.2	+	5	523	c.49G>A	c.(49-51)GAG>AAG	p.E17K	ZNF544_uc010eun.1_RNA|ZNF544_uc010yhw.1_RNA|ZNF544_uc010yhx.1_Missense_Mutation_p.E17K|ZNF544_uc010yhy.1_Missense_Mutation_p.E17K|ZNF544_uc002qrt.3_5'UTR|ZNF544_uc002qru.3_5'UTR|ZNF544_uc002qrv.2_RNA	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TGTGTGCTTCGAGGATGTGGC	0.507			NA											13	223					0	0	0.105934	0	0
ZNF8	7554	broad.mit.edu	37	19	58805974	58805974	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:58805974A>G	uc002qry.1	+	4	930	c.800A>G	c.(799-801)AAC>AGC	p.N267S	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	267	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		AAGTCGTTTAACCATAACGCA	0.488			NA											7	29					0	0	0.02938	0	0
SNTG2	54221	broad.mit.edu	37	2	1263181	1263181	+	Missense_Mutation	SNP	C	C	T	rs145354756	by1000genomes	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:1263181C>T	uc002qwq.2	+	13	1173	c.1045C>T	c.(1045-1047)CAC>TAC	p.H349Y	SNTG2_uc010ewi.2_Missense_Mutation_p.H222Y	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	349	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		AAGGACCTATCACCTCTGTGA	0.413			NA											4	72					0	0	0.009096	0	0
NLRC4	58484	broad.mit.edu	37	2	32475459	32475459	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:32475459G>A	uc002roi.2	-	4	1720	c.1474C>T	c.(1474-1476)CGG>TGG	p.R492W	NLRC4_uc002roj.1_Missense_Mutation_p.R492W|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	492					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAGGTGTACCGGAGCAGGCTG	0.517			NA											4	44					0	0	0.009096	0	0
CEBPZ	10153	broad.mit.edu	37	2	37430153	37430153	+	Splice_Site	SNP	T	T	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:37430153T>A	uc002rpz.2	-	14	2915	c.2885_splice	c.e14-1	p.G962_splice		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				TTCTTGGCCCTAAAAAAAATT	0.269			NA											3	47					0	0	0.009096	0	0
STK36	27148	broad.mit.edu	37	2	219563892	219563892	+	Missense_Mutation	SNP	C	C	T	rs142956585		TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:219563892C>T	uc002viu.2	+	26	3891	c.3625C>T	c.(3625-3627)CGG>TGG	p.R1209W	STK36_uc002viv.2_Missense_Mutation_p.R1188W|STK36_uc002viw.2_Missense_Mutation_p.R387W|STK36_uc002vix.2_Missense_Mutation_p.R254W	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1209					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding	p.R1209P(1)		ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GGCTGGTATCCGGCGCAATGT	0.592			NA											4	38					0	0	0.009096	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37546833	37546833	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr20:37546833G>A	uc002xje.2	+	11	1417	c.1228G>A	c.(1228-1230)GAA>AAA	p.E410K	PPP1R16B_uc010ggc.2_Missense_Mutation_p.E368K	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	410					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GCTACTCTCCGAATTTCCTAC	0.567			NA											12	148					0	0	0.020292	0	0
TOP1	7150	broad.mit.edu	37	20	39725971	39725971	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr20:39725971A>G	uc002xjl.2	+	10	1088	c.842A>G	c.(841-843)GAC>GGC	p.D281G	TOP1_uc010gge.1_RNA	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	281					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	TTCTTTAAAGACTGGAGAAAG	0.348			NA	T	NUP98	AML*								7	97					0	0	0.038147	0	0
IQCB1	9657	broad.mit.edu	37	3	121544968	121544968	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr3:121544968A>C	uc010hre.1	-	5	538	c.323T>G	c.(322-324)CTT>CGT	p.L108R	IQCB1_uc003eek.2_Missense_Mutation_p.L108R|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	108					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		AGCTGATGGAAGTAATTCATT	0.363			NA											14	27					0	0	0.105934	0	0
THAP6	152815	broad.mit.edu	37	4	76442122	76442122	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr4:76442122G>C	uc003him.2	+	3	318	c.221G>C	c.(220-222)AGT>ACT	p.S74T	RCHY1_uc003hij.2_5'Flank|RCHY1_uc003hik.2_5'Flank|RCHY1_uc003hil.2_5'Flank|RCHY1_uc010iip.2_5'Flank|RCHY1_uc010iiq.2_5'Flank|RCHY1_uc010iir.2_5'Flank|THAP6_uc010iis.1_Missense_Mutation_p.S33T|THAP6_uc003hin.2_Missense_Mutation_p.S74T|THAP6_uc011cbm.1_Missense_Mutation_p.S74T|THAP6_uc010iiu.1_RNA|THAP6_uc003hio.1_RNA|THAP6_uc010iiv.2_Missense_Mutation_p.S74T	NM_144721	NP_653322	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	74	THAP-type.					microtubule cytoskeleton	DNA binding|metal ion binding				0			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TTTGACAGAAGTGCTCCAAAT	0.393			NA											5	73					0	0	0.014758	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64748738	64748738	+	Silent	SNP	T	T	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:64748738T>G	uc003jtp.2	-	5	1453	c.639A>C	c.(637-639)ACA>ACC	p.T213T	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	213					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TGCCACTTCTTGTGAAATCTA	0.348			NA											6	105					0	0	0.02938	0	0
MAST4	375449	broad.mit.edu	37	5	66400349	66400349	+	Silent	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:66400349C>T	uc003jut.1	+	9	803	c.735C>T	c.(733-735)ATC>ATT	p.I245I	MAST4_uc003jus.2_Silent_p.I245I|MAST4_uc003juu.1_Silent_p.I255I|MAST4_uc011cra.1_Silent_p.I228I|MAST4_uc010ixa.2_RNA|MAST4_uc003juv.2_Silent_p.I240I|MAST4_uc003juw.2_Silent_p.I240I	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	437						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGGGCCTCATCACCTCACGAT	0.413			NA											4	36					0	0	0.014758	0	0
RIOK2	55781	broad.mit.edu	37	5	96503577	96503577	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:96503577C>T	uc003kmz.2	-	8	1101	c.991G>A	c.(991-993)GGA>AGA	p.G331R	RIOK2_uc003kna.3_Missense_Mutation_p.G331R	NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	331	Protein kinase.						ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		AATTCAGATCCCTCTTTTGTT	0.418			NA											12	250					0	0	0.105934	0	0
RELL2	285613	broad.mit.edu	37	5	141018407	141018407	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:141018407G>C	uc003lli.2	+	3	1078	c.230G>C	c.(229-231)CGC>CCC	p.R77P	HDAC3_uc003llf.2_5'Flank|HDAC3_uc010jgd.1_5'Flank|HDAC3_uc010jge.1_5'Flank|RELL2_uc003llh.2_Missense_Mutation_p.R77P|RELL2_uc003llg.2_Missense_Mutation_p.R11P|RELL2_uc010jgf.2_Missense_Mutation_p.R11P	NM_001130029	NP_001123501	Q8NC24	RELL2_HUMAN	RELT-like 2	77						integral to membrane|plasma membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGATTGTTCGCTGCATCATC	0.507			NA											4	85					0	0	0.014758	0	0
FAM71B	153745	broad.mit.edu	37	5	156589943	156589943	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:156589943G>A	uc003lwn.2	-	2	1433	c.1333C>T	c.(1333-1335)CAT>TAT	p.H445Y		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	445	Bipartite nuclear localization signal (Potential).					nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGCGGTGATGAGAACTTTTC	0.502			NA											7	153					0	0	0.047766	0	0
FILIP1	27145	broad.mit.edu	37	6	76023514	76023514	+	Silent	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr6:76023514A>G	uc003pia.2	-	5	2407	c.2034T>C	c.(2032-2034)TCT>TCC	p.S678S	FILIP1_uc003phy.1_Silent_p.S678S|FILIP1_uc003phz.2_Silent_p.S579S|FILIP1_uc010kbe.2_Silent_p.S681S|FILIP1_uc003pib.1_Silent_p.S430S	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	678	Potential.									skin(3)|ovary(1)	4						CTAGTTGTTGAGAGAGGAAGT	0.433			NA											16	248					0	0	0.024245	0	0
FGFR1OP	11116	broad.mit.edu	37	6	167417806	167417806	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr6:167417806G>A	uc003qvj.2	+	5	440	c.355G>A	c.(355-357)GCA>ACA	p.A119T	CCR6_uc003qvl.2_5'UTR|FGFR1OP_uc011egp.1_Missense_Mutation_p.A119T|FGFR1OP_uc003qvk.2_Missense_Mutation_p.A119T	NM_007045	NP_008976	O95684	FR1OP_HUMAN	FGFR1 oncogene partner isoform a	119					G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(1)	1		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)		TATAATTGAAGCAGAAGGTAC	0.413			NA	T	FGFR1	MPD|NHL								11	43					0	0	0.069234	0	0
MLLT4	4301	broad.mit.edu	37	6	168299086	168299086	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr6:168299086G>A	uc003qwd.2	+	11	1658	c.1516G>A	c.(1516-1518)GCT>ACT	p.A506T	MLLT4_uc003qwb.1_Missense_Mutation_p.A491T|MLLT4_uc003qwc.1_Missense_Mutation_p.A507T|MLLT4_uc003qwf.2_Missense_Mutation_p.A192T	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	507					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TCAGGATCATGCTCTTGCAAA	0.453			NA	T	MLL	AL								5	33					0	0	0.02938	0	0
KRIT1	889	broad.mit.edu	37	7	91870326	91870326	+	Silent	SNP	A	A	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr7:91870326A>T	uc003ulq.1	-	3	414	c.243T>A	c.(241-243)CCT>CCA	p.P81P	KRIT1_uc010lev.1_5'UTR|KRIT1_uc003ulr.1_Silent_p.P81P|KRIT1_uc003uls.1_Silent_p.P81P|KRIT1_uc003ult.1_Silent_p.P81P|KRIT1_uc003ulu.1_Silent_p.P81P|KRIT1_uc003ulv.1_Silent_p.P81P	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	81					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CCTGGTTTGCAGGAGAAATTG	0.313			NA							Familial_Cerebral_Cavernous_Angioma				22	65					0	0	0.076483	0	0
GIGYF1	64599	broad.mit.edu	37	7	100284038	100284038	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr7:100284038G>C	uc003uwg.1	-	8	1722	c.713C>G	c.(712-714)GCT>GGT	p.A238G		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	238										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CCGCCAGCCAGCAGAGCGGGG	0.637			NA											3	38					0	0	0.004672	0	0
MET	4233	broad.mit.edu	37	7	116412024	116412024	+	Nonsense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr7:116412024C>G	uc003vij.2	+	14	3196	c.3009C>G	c.(3007-3009)TAC>TAG	p.Y1003*	MET_uc010lkh.2_Nonsense_Mutation_p.Y1021*|MET_uc011knj.1_Nonsense_Mutation_p.Y573*	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1003	Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.L982_D1028del(3)|p.D981_D1028del(1)|p.982_1028del47(1)|p.?(1)		upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CTGTAGACTACCGAGCTACTT	0.383			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				6	34					0	0	0.02938	0	0
ADCY8	114	broad.mit.edu	37	8	132052081	132052081	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr8:132052081C>G	uc003ytd.3	-	1	755	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	ADCY8_uc010mds.2_Missense_Mutation_p.E167Q	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	167	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TAGAGGCGTTCCAAATCCCGA	0.527			NA								HNSCC(32;0.087)			13	91					0	0	0.024245	0	0
ZNF623	9831	broad.mit.edu	37	8	144733396	144733396	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr8:144733396A>T	uc003yzd.2	+	1	1443	c.1354A>T	c.(1354-1356)ATT>TTT	p.I452F	ZNF623_uc011lkp.1_Missense_Mutation_p.I412F|ZNF623_uc003yzc.2_Missense_Mutation_p.I412F	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	452	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCACCAGATTATTCACACTGG	0.463			NA											5	86					0	0	0.014758	0	0
TESK1	7016	broad.mit.edu	37	9	35608495	35608495	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr9:35608495C>T	uc003zxa.2	+	9	1325	c.989C>T	c.(988-990)ACA>ATA	p.T330I	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Missense_Mutation_p.T170I	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	330					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACCGCCCTGACACACAATCAG	0.572			NA											4	13					0	0	0.021553	0	0
FOXB2	442425	broad.mit.edu	37	9	79634826	79634826	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr9:79634826T>C	uc004ako.1	+	1	256	c.256T>C	c.(256-258)TTC>CTC	p.F86L		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	86	Fork-head.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CAAGGGTAGCTTCTGGGCGCT	0.632			NA											3	24					0	0	0.009096	0	0
AKAP4	8852	broad.mit.edu	37	X	49955748	49955748	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:49955748A>G	uc004dow.1	-	6	2544	c.2420T>C	c.(2419-2421)GTT>GCT	p.V807A	AKAP4_uc004dov.1_Missense_Mutation_p.V424A|AKAP4_uc010njp.1_Missense_Mutation_p.V629A|AKAP4_uc004dou.1_Missense_Mutation_p.V798A	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	807					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					TTTAGCTGAAACCTGAGGAAG	0.507			NA											7	130					0	0	0.038147	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722914	64722914	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:64722914T>C	uc010nko.2	+	5	2312	c.2303T>C	c.(2302-2304)ATG>ACG	p.M768T		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	768							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						TGGGTTGGAATGTGCAATGAT	0.478			NA											13	76					0	0	0.09319	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004327	75004327	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:75004327A>C	uc004ecj.1	-	1	745	c.560T>G	c.(559-561)ATC>AGC	p.I187S		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	187	MAGE 1.									ovary(1)|skin(1)	2						ATTCAAGAGGATGTGGCCTAG	0.502			NA											5	41					0	0	0.014758	0	0
TRMT2B	79979	broad.mit.edu	37	X	100274014	100274014	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:100274014G>A	uc004egq.2	-	12	1633	c.1334C>T	c.(1333-1335)ACG>ATG	p.T445M	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Missense_Mutation_p.T445M|TRMT2B_uc004egs.2_Missense_Mutation_p.T445M|TRMT2B_uc004egt.2_Missense_Mutation_p.T445M|TRMT2B_uc004egu.2_Missense_Mutation_p.T326M|TRMT2B_uc004egv.2_Missense_Mutation_p.T400M	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	445							tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						AAAAACTAGCGTGTGGATGGC	0.348			NA											7	136					0	0	0.047766	0	0
AMOT	154796	broad.mit.edu	37	X	112024327	112024327	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:112024327G>T	uc004epr.2	-	9	2260	c.2260C>A	c.(2260-2262)CAG>AAG	p.Q754K	AMOT_uc004eps.2_Missense_Mutation_p.Q345K|AMOT_uc011mtc.1_5'UTR|hsa-mir-4329|MI0015901_5'Flank	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	754					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TCAATAATCTGGGCATGGAGG	0.413			NA											13	162					4.36969e-10	5.06329e-10	0.105934	1	0
VBP1	7411	broad.mit.edu	37	X	154456758	154456758	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:154456758G>T	uc004fnc.2	+	4	437	c.378G>T	c.(376-378)TGG>TGT	p.W126C	VBP1_uc004fnd.2_Missense_Mutation_p.W89C	NM_003372	NP_003363	P61758	PFD3_HUMAN	von Hippel-Lindau binding protein 1	126					'de novo' posttranslational protein folding	nucleus|prefoldin complex	unfolded protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGTGTCTGTGGTTGGGGGTAA	0.398			NA											11	155					6.40141e-05	7.30161e-05	0.080935	1	0
PHLDA2	7262	broad.mit.edu	37	11	2950237	2950238	+	Frame_Shift_Ins	INS	-	-	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:2950237_2950238insG	uc001lxa.1	-	1	413_414	c.357_358insC	c.(355-360)CCCGCCfs	p.P119fs		NM_003311	NP_003302	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain family A member	119_120					apoptosis	cytoplasm|membrane					0		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCGGGTGCGGCGGGTGCGGTGC	0.743			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA