Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRAMEF12	390999	broad.mit.edu	37	1	12837248	12837248	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:12837248C>A	uc001aui.2	+	3	985	c.958C>A	c.(958-960)CAG>AAG	p.Q320K		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	320	LRR 1.									ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCATCCGTCAGCTAAAAGA	0.582			NA											33	130					8.4185e-14	1.07738e-13	0.012213	1	0
PRDM2	7799	broad.mit.edu	37	1	14109132	14109132	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:14109132G>C	uc001avi.2	+	8	5698	c.4842G>C	c.(4840-4842)AGG>AGC	p.R1614S	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.R1614S|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.R1413S|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1614						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TGCACGTGAGGGTACAGAAAA	0.458			NA											12	60					0	0	0.013537	0	0
CROCC	9696	broad.mit.edu	37	1	17250965	17250965	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:17250965C>T	uc001azt.2	+	3	411	c.342C>T	c.(340-342)GTC>GTT	p.V114V	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_Intron	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	114	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		ACAATGCGGTCAGCGAGAGGG	0.632			NA											12	22					0	0	0.010729	0	0
EPHA8	2046	broad.mit.edu	37	1	22927868	22927868	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:22927868G>T	uc001bfx.1	+	16	2930	c.2805G>T	c.(2803-2805)GTG>GTT	p.V935V		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	935	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GCCTCACCGTGGGGGACTGGC	0.677			NA											28	59					9.39395e-14	1.19231e-13	0.00632	1	0
FUCA1	2517	broad.mit.edu	37	1	24172269	24172269	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:24172269T>A	uc001bie.2	-	8	1382	c.1337A>T	c.(1336-1338)CAG>CTG	p.Q446L		NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor	446					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		GGGTGGCAACTGGGGTAGAGA	0.463			NA											4	87					0	0	0.009096	0	0
EXTL1	2134	broad.mit.edu	37	1	26357001	26357001	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:26357001G>T	uc001blf.2	+	4	1883	c.1016G>T	c.(1015-1017)CGG>CTG	p.R339L		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	339	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCCTGCACGGGTCCTCGCC	0.507			NA											19	65					8.04996e-18	1.09385e-17	0.012319	1	0
DLGAP3	58512	broad.mit.edu	37	1	35351192	35351192	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:35351192G>C	uc001byc.2	-	5	1801	c.1801C>G	c.(1801-1803)CCG>GCG	p.P601A		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	601					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				GCCCGGGGCGGCACCGGCGCC	0.761			NA											7	10					0	0	0.001984	0	0
HIVEP3	59269	broad.mit.edu	37	1	41978898	41978898	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:41978898G>A	uc001cgz.3	-	8	7207	c.5994C>T	c.(5992-5994)TCC>TCT	p.S1998S	HIVEP3_uc001cha.3_Silent_p.S1998S|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1998	4.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTCGGGCCGGGGAGCATCGCT	0.627			NA											27	52					0	0	0.003954	0	0
HIVEP3	59269	broad.mit.edu	37	1	41978901	41978901	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:41978901G>A	uc001cgz.3	-	8	7204	c.5991C>T	c.(5989-5991)TGC>TGT	p.C1997C	HIVEP3_uc001cha.3_Silent_p.C1997C|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1997					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGCCGGGGAGCATCGCTGGG	0.637			NA											29	54					0	0	0.005443	0	0
TIE1	7075	broad.mit.edu	37	1	43775150	43775150	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:43775150G>A	uc001ciu.2	+	9	1359	c.1280G>A	c.(1279-1281)CGT>CAT	p.R427H	TIE1_uc010okd.1_Missense_Mutation_p.R427H|TIE1_uc010oke.1_Missense_Mutation_p.R382H|TIE1_uc009vwq.2_Missense_Mutation_p.R383H|TIE1_uc010okf.1_Missense_Mutation_p.R72H|TIE1_uc010okg.1_Missense_Mutation_p.R72H|TIE1_uc010okc.1_3'UTR	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	427	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGGAGTGCCGTGTGTCCACA	0.572			NA											8	37					0	0	0.004482	0	0
KLF17	128209	broad.mit.edu	37	1	44596220	44596220	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:44596220C>T	uc001clp.2	+	3	1020	c.962C>T	c.(961-963)TCA>TTA	p.S321L		NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	321	C2H2-type 2.				regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GAAAGTTGTTCATGGTCTTTC	0.463			NA											44	62					0	0	0.009718	0	0
USP24	23358	broad.mit.edu	37	1	55590228	55590228	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:55590228C>T	uc001cyg.3	-	32	3554	c.3554G>A	c.(3553-3555)CGG>CAG	p.R1185Q		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1345					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						AAGATCAAGCCGTCCTGCAGC	0.428			NA											7	31					0	0	0.001984	0	0
DOCK7	85440	broad.mit.edu	37	1	62961329	62961329	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:62961329G>A	uc001daq.2	-	39	4954	c.4920C>T	c.(4918-4920)CTC>CTT	p.L1640L	DOCK7_uc001dan.2_Silent_p.L1501L|DOCK7_uc001dao.2_Silent_p.L1501L|DOCK7_uc001dap.2_Silent_p.L1618L|DOCK7_uc001dam.2_Silent_p.L820L|DOCK7_uc010oov.1_Silent_p.L379L	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1649	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GAATCATATGGAGATTGAAAA	0.333			NA											3	20					0	0	0.004672	0	0
LRRC7	57554	broad.mit.edu	37	1	70489004	70489004	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:70489004C>T	uc001dep.2	+	15	1657	c.1627C>T	c.(1627-1629)CCA>TCA	p.P543S	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	543						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CATGTGTACTCCATTGCCAGT	0.542			NA											21	75					0	0	0.014323	0	0
LMO4	8543	broad.mit.edu	37	1	87805833	87805833	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:87805833T>C	uc001dmi.2	+	4	1217	c.437T>C	c.(436-438)ATC>ACC	p.I146T	LMO4_uc001dmj.2_Missense_Mutation_p.I146T	NM_006769	NP_006760	P61968	LMO4_HUMAN	LIM domain only 4	146	LIM zinc-binding 2.				neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding				0		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		ACAGCTCTCATCAATGGCCAT	0.438			NA											18	58					0	0	0.008871	0	0
PRMT6	55170	broad.mit.edu	37	1	107600045	107600045	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:107600045C>G	uc010ous.1	+	1	779	c.708C>G	c.(706-708)ATC>ATG	p.I236M		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	236					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		ACTCGGAGATCGTTGTGCAGG	0.672			NA											10	70					0	0	0.010729	0	0
SLC6A17	388662	broad.mit.edu	37	1	110714814	110714814	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:110714814G>T	uc009wfq.2	+	3	880	c.419G>T	c.(418-420)GGG>GTG	p.G140V		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	140	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CCCCGCCTGGGGGGCATCGGC	0.632			NA											6	10					3.59834e-05	3.96762e-05	0.001168	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367750	145367750	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:145367750G>T	uc001end.3	+	85	10606	c.10571G>T	c.(10570-10572)GGA>GTA	p.G3524V	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3449											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		aaaagaaggggaagaagatca	0.249			NA											10	47					1.76689e-08	2.06659e-08	0.006214	1	0
LOC200030	200030	broad.mit.edu	37	1	148017573	148017573	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:148017573G>A	uc001eqf.2	-	12	1765	c.1730C>T	c.(1729-1731)TCG>TTG	p.S577L	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc009wkf.1_RNA|NBPF14_uc001eqq.2_Missense_Mutation_p.S237L|NBPF14_uc001eqs.1_Missense_Mutation_p.S116L	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	577	NBPF 3.					cytoplasm					0						AGACTTGTACGAGGCCAACAT	0.478			NA											25	459					0	0	0.01441	0	0
FLG	2312	broad.mit.edu	37	1	152280700	152280700	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:152280700C>A	uc001ezu.1	-	3	6698	c.6662G>T	c.(6661-6663)AGA>ATA	p.R2221I		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2221	Ser-rich.|Filaggrin 13.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGTGAGTGTCTAGAGCTGTC	0.547			NA							Ichthyosis				138	203					2.30743e-64	3.37353e-64	0.01441	1	0
UBAP2L	9898	broad.mit.edu	37	1	154207096	154207096	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:154207096G>T	uc001fep.3	+	5	476	c.309G>T	c.(307-309)AAG>AAT	p.K103N	UBAP2L_uc009wot.2_Missense_Mutation_p.K103N|UBAP2L_uc010pek.1_Missense_Mutation_p.K102N|UBAP2L_uc010pel.1_Missense_Mutation_p.K102N|UBAP2L_uc001fen.1_Missense_Mutation_p.K102N|UBAP2L_uc010pem.1_Missense_Mutation_p.K102N|UBAP2L_uc010pen.1_Missense_Mutation_p.K6N	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	103					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGAAGAAGAAGGGAGTCTCAG	0.507			NA											14	29					4.93089e-13	6.17364e-13	0.00245	1	0
NES	10763	broad.mit.edu	37	1	156639370	156639370	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:156639370C>T	uc001fpq.2	-	4	4743	c.4610G>A	c.(4609-4611)GGC>GAC	p.G1537D		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1537	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGACCCTGGCCATTAACACC	0.582			NA											26	69					0	0	0.003954	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156910211	156910211	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:156910211C>T	uc001fqo.2	-	35	4441	c.3401G>A	c.(3400-3402)GGG>GAG	p.G1134E	ARHGEF11_uc010phu.1_Missense_Mutation_p.G550E|ARHGEF11_uc001fqn.2_Missense_Mutation_p.G1174E	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1134					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGCTGGGACCCAGTGCCTGT	0.602			NA											8	53					0	0	0.004482	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576407	158576407	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:158576407A>T	uc010pio.1	+	1	179	c.179A>T	c.(178-180)TAC>TTC	p.Y60F		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					ACCCCCATGTACCTCTTCCTT	0.517			NA											45	195					0	0	0.01441	0	0
SPTA1	6708	broad.mit.edu	37	1	158613152	158613152	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:158613152T>A	uc001fst.1	-	31	4601	c.4402A>T	c.(4402-4404)AAA>TAA	p.K1468*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1468	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATCTCTTCTTTGGCATAGTGT	0.443			NA											20	36					0	0	0.012319	0	0
SPTA1	6708	broad.mit.edu	37	1	158646039	158646039	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:158646039G>T	uc001fst.1	-	8	1203	c.1004C>A	c.(1003-1005)CCT>CAT	p.P335H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	335	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGCATCTGAAGGATGGGAAAG	0.483			NA											42	82					3.4345e-17	4.59924e-17	0.011902	1	0
OR6K6	128371	broad.mit.edu	37	1	158725561	158725561	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:158725561T>A	uc001fsw.1	+	1	956	c.956T>A	c.(955-957)CTG>CAG	p.L319Q		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	319	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					ATCTATAGCCTGAAAAACAAG	0.433			NA											17	65					0	0	0.006122	0	0
PYHIN1	149628	broad.mit.edu	37	1	158911901	158911901	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:158911901G>A	uc001ftb.2	+	5	959	c.714G>A	c.(712-714)ATG>ATA	p.M238I	PYHIN1_uc001ftc.2_Missense_Mutation_p.M229I|PYHIN1_uc001ftd.2_Missense_Mutation_p.M238I|PYHIN1_uc001fte.2_Missense_Mutation_p.M229I	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	238	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					AAAGAAGAATGTTTCATGCTA	0.328			NA											14	21					0	0	0.003163	0	0
IFI16	3428	broad.mit.edu	37	1	158986358	158986358	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:158986358C>A	uc001ftf.1	+	5	1024	c.417C>A	c.(415-417)CCC>CCA	p.P139P	IFI16_uc001ftg.2_Silent_p.P139P|IFI16_uc010pis.1_Intron	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	139	Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					AGGCTGGACCCAAAGGGAGTA	0.478			NA											18	27					6.94344e-10	8.35383e-10	0.006122	1	0
LAMC1	3915	broad.mit.edu	37	1	183090875	183090875	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:183090875G>C	uc001gpy.3	+	12	2265	c.2008G>C	c.(2008-2010)GAT>CAT	p.D670H		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	670	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATATTTGGATGATGTCACCCT	0.473			NA											3	29					0	0	0.009096	0	0
TPR	7175	broad.mit.edu	37	1	186344044	186344044	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:186344044C>T	uc001grv.2	-	1	414	c.117G>A	c.(115-117)CTG>CTA	p.L39L	C1orf27_uc001grw.2_5'Flank|C1orf27_uc010poq.1_5'Flank|C1orf27_uc010por.1_5'Flank|TPR_uc010pop.1_Silent_p.L115L	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	39	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GCCGCCCCTTCAGGCCATCGA	0.537			NA	T	NTRK1	papillary thyroid								34	39					0	0	0.003755	0	0
CFH	3075	broad.mit.edu	37	1	196712628	196712628	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:196712628G>T	uc001gtj.3	+	20	3420	c.3180G>T	c.(3178-3180)GTG>GTT	p.V1060V		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1060	Sushi 18.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CTTATATAGTGTCGAGACAGA	0.388			NA											29	28					3.99451e-17	5.33371e-17	0.009535	1	0
F13B	2165	broad.mit.edu	37	1	197021789	197021789	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:197021789C>T	uc001gtt.1	-	9	1574	c.1530G>A	c.(1528-1530)GTG>GTA	p.V510V		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	510	Sushi 8.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AAGGATATTTCACTTCTCCTC	0.323			NA											5	44					0	0	0.000602	0	0
ASPM	259266	broad.mit.edu	37	1	197074087	197074087	+	Silent	SNP	T	T	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:197074087T>G	uc001gtu.2	-	18	4551	c.4294A>C	c.(4294-4296)AGA>CGA	p.R1432R	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1432					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTCCATTTTCTGAACATAGAT	0.313			NA											9	48					0	0	0.004482	0	0
IPO9	55705	broad.mit.edu	37	1	201839778	201839778	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:201839778A>G	uc001gwz.2	+	18	2251	c.2201A>G	c.(2200-2202)GAG>GGG	p.E734G		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	734					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						TGGCATGATGAGCAGGGCCAC	0.582			NA											15	51					0	0	0.00245	0	0
LGR6	59352	broad.mit.edu	37	1	202287145	202287145	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:202287145G>A	uc001gxu.2	+	18	1714	c.1714G>A	c.(1714-1716)GTG>ATG	p.V572M	LGR6_uc001gxv.2_Missense_Mutation_p.V520M|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.V433M	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	572	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GTGGGCCATCGTGTTGCTCTC	0.612			NA											18	73					0	0	0.00499	0	0
CENPF	1063	broad.mit.edu	37	1	214818194	214818194	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:214818194G>C	uc001hkm.2	+	13	5455	c.5281G>C	c.(5281-5283)GAT>CAT	p.D1761H		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1857					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GGTACCTATGGATTTCCTGGG	0.408	Colon(80;575 1284 11000 14801 43496)		NA											13	39					0	0	0.00245	0	0
ZNF678	339500	broad.mit.edu	37	1	227843036	227843036	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:227843036C>G	uc001hqw.1	+	4	1430	c.1085C>G	c.(1084-1086)TCA>TGA	p.S362*	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	417					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				ACTCAATTCTCAAACCTCACT	0.383			NA											5	37					0	0	0.000602	0	0
WNT9A	7483	broad.mit.edu	37	1	228112026	228112026	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:228112026G>T	uc001hri.2	-	3	516	c.428C>A	c.(427-429)GCG>GAG	p.A143E		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	143					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				CATGCGGCCCGCGCTGCACGC	0.652			NA											30	67					7.38237e-10	8.85884e-10	0.00632	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232601073	232601074	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:232601073_232601074TC>AA	uc001hvg.2	-	7	2490_2491	c.2332_2333GA>TT	c.(2332-2334)GAC>TTC	p.D778F	SIPA1L2_uc001hvf.2_5'Flank	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	778	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TAAAAGGAAGTCCCGGAACACG	0.45			NA											16	94					0	0	0.004672	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394715	233394715	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:233394715C>T	uc001hvl.2	-	5	1128	c.893G>A	c.(892-894)CGG>CAG	p.R298Q	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	298						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GCTTTGTACCCGTTCCCTTAT	0.552			NA											7	83					0	0	0.001984	0	0
ARID4B	51742	broad.mit.edu	37	1	235359370	235359370	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:235359370C>A	uc001hwq.2	-	18	2400	c.1902G>T	c.(1900-1902)AAG>AAT	p.K634N	ARID4B_uc001hwr.2_Missense_Mutation_p.K548N|ARID4B_uc001hws.3_Missense_Mutation_p.K548N|ARID4B_uc001hwp.2_5'Flank|ARID4B_uc001hwt.3_Missense_Mutation_p.K315N	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	634					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GATGTTTTATCTTTGGCACAT	0.269			NA											4	18					0.00909568	0.00942198	0.009096	1	0
RYR2	6262	broad.mit.edu	37	1	237756921	237756921	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:237756921G>T	uc001hyl.1	+	33	4541	c.4421G>T	c.(4420-4422)GGA>GTA	p.G1474V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1474	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATGAAAAAGGAAAAGTGCAT	0.383			NA											11	38					3.07112e-06	3.47759e-06	0.010729	1	0
RYR2	6262	broad.mit.edu	37	1	237774159	237774159	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:237774159T>G	uc001hyl.1	+	36	4901	c.4781T>G	c.(4780-4782)GTC>GGC	p.V1594G		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1594	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGTCACACGTCCTGTGGAGC	0.547			NA											4	19					0	0	0.000602	0	0
ZP4	57829	broad.mit.edu	37	1	238050811	238050811	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:238050811T>C	uc001hym.2	-	5	604	c.604A>G	c.(604-606)AAC>GAC	p.N202D	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	202	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GAGGTCACGTTCCGAGACACA	0.527	NSCLC(166;160 2029 11600 18754 19936)		NA											43	74					0	0	0.01441	0	0
ZP4	57829	broad.mit.edu	37	1	238051760	238051760	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:238051760T>C	uc001hym.2	-	4	451	c.451A>G	c.(451-453)AGA>GGA	p.R151G	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	151	P-type.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CATGGCAGTCTGTCCCGTGCT	0.478	NSCLC(166;160 2029 11600 18754 19936)		NA											22	60					0	0	0.00278	0	0
OR6F1	343169	broad.mit.edu	37	1	247875228	247875228	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:247875228A>T	uc001idj.1	-	1	830	c.830T>A	c.(829-831)CTG>CAG	p.L277Q		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CACAGTGTTCAGGACGTGGAC	0.453			NA											31	63					0	0	0.008361	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129095	248129095	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:248129095G>T	uc010pzd.1	+	1	462	c.462G>T	c.(460-462)AAG>AAT	p.K154N	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	154	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGAGCAAGAAGATCTGCTGCC	0.443	Melanoma(45;390 1181 23848 28461 41504)		NA											67	121					2.18419e-29	3.12414e-29	0.01441	1	0
OR2T2	401992	broad.mit.edu	37	1	248616271	248616271	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:248616271C>A	uc001iek.1	+	1	173	c.173C>A	c.(172-174)ACA>AAA	p.T58K		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	58	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGCCTCCACACACCCATGTAC	0.512			NA											26	128					1.22674e-20	1.72266e-20	0.00874	1	0
SLC39A12	221074	broad.mit.edu	37	10	18331726	18331726	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr10:18331726G>T	uc001ipo.2	+	13	2313	c.2040G>T	c.(2038-2040)CTG>CTT	p.L680L	SLC39A12_uc001ipn.2_Silent_p.L643L|SLC39A12_uc001ipp.2_Silent_p.L679L|SLC39A12_uc010qck.1_Silent_p.L546L	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	680	Poly-Leu.|Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TTTCTCTCCTGCTCTTGGCTA	0.343			NA											6	27					4.096e-09	4.8898e-09	0.001168	1	0
PTCHD3	374308	broad.mit.edu	37	10	27687694	27687694	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr10:27687694C>G	uc001itu.2	-	4	1951	c.1833G>C	c.(1831-1833)TTG>TTC	p.L611F		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	611	Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TTATGATGTACAAAACATATA	0.368			NA											5	26					0	0	0.000602	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37454056	37454056	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr10:37454056C>A	uc001iza.1	+	18	1968	c.1869C>A	c.(1867-1869)GAC>GAA	p.D623E		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	679						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AACAAAAGGACTATGAAGAAA	0.294			NA											12	25					7.03913e-09	8.36009e-09	0.013537	1	0
NRG3	10718	broad.mit.edu	37	10	84711230	84711230	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr10:84711230G>A	uc001kco.2	+	5	1087	c.1060G>A	c.(1060-1062)GAA>AAA	p.E354K	NRG3_uc010qlz.1_Missense_Mutation_p.E353K|NRG3_uc001kcp.2_Missense_Mutation_p.E133K|NRG3_uc001kcq.2_Missense_Mutation_p.E4K|NRG3_uc001kcr.2_Missense_Mutation_p.E4K	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	354	Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CACAGAGAGTGAAGAAGTTTA	0.403			NA											9	23					0	0	0.006214	0	0
PSD	5662	broad.mit.edu	37	10	104174961	104174961	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr10:104174961G>A	uc001kvg.1	-	4	1310	c.783C>T	c.(781-783)CCC>CCT	p.P261P	PSD_uc001kvh.1_5'UTR|PSD_uc009xxd.1_Silent_p.P261P	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	261					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GTGGAGATGGGGGGGCCTGCT	0.622			NA											27	13					0	0	0.00632	0	0
LRDD	55367	broad.mit.edu	37	11	799896	799896	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:799896C>A	uc001lro.1	-	15	2535	c.2393G>T	c.(2392-2394)CGT>CTT	p.R798L	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.R781L|LRDD_uc001lrl.1_Missense_Mutation_p.R641L|LRDD_uc001lrm.1_Missense_Mutation_p.R485L|LRDD_uc001lrn.1_Missense_Mutation_p.R641L|LRDD_uc001lrp.1_3'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	798	Death.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGACCCAGACGCCCAGCCAC	0.692			NA											3	28					6.4e-05	7.00664e-05	0.004672	1	0
OR51V1	283111	broad.mit.edu	37	11	5221760	5221760	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:5221760C>A	uc010qyz.1	-	1	171	c.171G>T	c.(169-171)GTG>GTT	p.V57V		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	57	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTCCATATCACATGGAGAA	0.527			NA											22	21					5.35356e-11	6.54324e-11	0.00278	1	0
OR52B2	255725	broad.mit.edu	37	11	6190980	6190980	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:6190980C>T	uc010qzy.1	-	1	577	c.577G>A	c.(577-579)GAC>AAC	p.D193N		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAGTGATGTCAGCACAGGCT	0.488	NSCLC(5;186 261 1778 7098 14207)		NA											11	5					0	0	0.008291	0	0
HPX	3263	broad.mit.edu	37	11	6462124	6462124	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:6462124T>A	uc001mdg.2	-	1	131	c.70A>T	c.(70-72)ACC>TCC	p.T24S	HPX_uc009yfc.2_RNA|HPX_uc010rai.1_Missense_Mutation_p.T24S	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	24	O-glycosylated at one, two and three sites.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GGAAGAGGGGTGGCAATGGCC	0.572			NA											9	10					0	0	0.010729	0	0
BTBD10	84280	broad.mit.edu	37	11	13443224	13443224	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:13443224C>T	uc001mkz.2	-	3	520	c.263G>A	c.(262-264)AGA>AAA	p.R88K	BTBD10_uc010rcl.1_Missense_Mutation_p.R96K|BTBD10_uc001mla.2_Missense_Mutation_p.R72K|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.R40K|BTBD10_uc010rcn.1_Missense_Mutation_p.R57K|BTBD10_uc009ygo.2_Missense_Mutation_p.R40K	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	88						nucleus					0				Epithelial(150;0.0214)		AGTCACATTTCTAATACAAGG	0.398			NA											6	24					0	0	0.001984	0	0
INSC	387755	broad.mit.edu	37	11	15260566	15260566	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:15260566C>A	uc001mly.2	+	11	1526	c.1480C>A	c.(1480-1482)CTG>ATG	p.L494M	INSC_uc001mlz.2_Missense_Mutation_p.L447M|INSC_uc001mma.2_Missense_Mutation_p.L447M|INSC_uc010rcs.1_Missense_Mutation_p.L482M|INSC_uc001mmb.2_Missense_Mutation_p.L447M|INSC_uc001mmc.2_Missense_Mutation_p.L405M	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	494					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TGCAGTGACCCTGGCTCGTCT	0.602			NA											23	7					1.90627e-21	2.68505e-21	0.012319	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16863110	16863110	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:16863110G>A	uc001mmo.2	-	9	871	c.856C>T	c.(856-858)CGA>TGA	p.R286*	PLEKHA7_uc010rcu.1_Nonsense_Mutation_p.R286*	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	286					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						AGTGACGATCGAGACAGCACC	0.567			NA											6	55					0	0	0.004482	0	0
FANCF	2188	broad.mit.edu	37	11	22646799	22646799	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:22646799G>A	uc001mql.1	-	1	589	c.558C>T	c.(556-558)GCC>GCT	p.A186A		NM_022725	NP_073562	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	186					DNA repair	nucleoplasm	protein binding			skin(1)	1						TGAGAAACCTGGCGGGACGCT	0.622			NA	N|F			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia		OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	42					0	0	0.01441	0	0
PHF21A	51317	broad.mit.edu	37	11	45967443	45967443	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:45967443G>A	uc001ncc.3	-	14	2021	c.1397C>T	c.(1396-1398)ACT>ATT	p.T466I	PHF21A_uc001ncb.3_Intron|PHF21A_uc009ykx.2_Intron|PHF21A_uc001nce.2_Missense_Mutation_p.T467I|PHF21A_uc001nca.1_Missense_Mutation_p.T202I	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	466					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						TGCAGGGAAAGTGAATGTGGT	0.507			NA											7	64					0	0	0.001984	0	0
OR4A47	403253	broad.mit.edu	37	11	48510625	48510625	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:48510625C>G	uc010rhx.1	+	1	281	c.281C>G	c.(280-282)TCT>TGT	p.S94C		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCCTTCCAATCTTGCATGGCC	0.438			NA											17	120					0	0	0.007413	0	0
OR4A47	403253	broad.mit.edu	37	11	48510902	48510902	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:48510902C>T	uc010rhx.1	+	1	558	c.558C>T	c.(556-558)GTC>GTT	p.V186V		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGAAACTGGTCTGCACTGACA	0.433			NA											22	125					0	0	0.00278	0	0
OR4A16	81327	broad.mit.edu	37	11	55111023	55111023	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:55111023T>A	uc010rie.1	+	1	347	c.347T>A	c.(346-348)ATG>AAG	p.M116K		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TTGGTGGTGATGGCCTATGAT	0.458			NA											29	124					0	0	0.008361	0	0
OR4C6	219432	broad.mit.edu	37	11	55433179	55433179	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:55433179G>T	uc001nht.3	+	3	802	c.537G>T	c.(535-537)TTG>TTT	p.L179F	OR4C6_uc010rik.1_Missense_Mutation_p.L179F	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TATGTGATTTGTTTCAGTTGT	0.433			NA											35	60					9.04072e-19	1.2431e-18	0.003271	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735495	55735495	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:55735495C>G	uc010rit.1	-	1	445	c.445G>C	c.(445-447)GGG>CGG	p.G149R		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					CATGTTTCCCCAATTACTACA	0.408			NA											13	34					0	0	0.013537	0	0
OR8K3	219473	broad.mit.edu	37	11	56085854	56085854	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:56085854G>T	uc010rjf.1	+	1	72	c.72G>T	c.(70-72)CAG>CAT	p.Q24H		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CTGAGCTGCAGGCACCATTAT	0.433			NA											32	62					1.88708e-17	2.54922e-17	0.008361	1	0
CLP1	10978	broad.mit.edu	37	11	57428602	57428602	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:57428602G>A	uc001nkw.2	+	3	1111	c.972G>A	c.(970-972)GTG>GTA	p.V324V	CLP1_uc010rjw.1_Silent_p.V260V|CLP1_uc009yml.2_Silent_p.V324V	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	324					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						TTTCAGATGTGAAAATCTACA	0.468			NA											32	152					0	0	0.003271	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799084	57799084	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:57799084G>T	uc010rjz.1	+	1	660	c.660G>T	c.(658-660)GTG>GTT	p.V220V	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	220	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TCATTGCTGTGTCCTATGGCA	0.562			NA											26	80					7.92952e-12	9.76917e-12	0.003954	1	0
OR10W1	81341	broad.mit.edu	37	11	58034596	58034596	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:58034596G>T	uc001nmq.1	-	1	1137	c.735C>A	c.(733-735)TGC>TGA	p.C245*		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C245*(1)		ovary(1)	1		Breast(21;0.0589)				TGAAGGCACAGCAGCCATACT	0.592			NA											17	64					4.14922e-12	5.1255e-12	0.004007	1	0
OR5A1	219982	broad.mit.edu	37	11	59211268	59211268	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:59211268C>T	uc001nnx.1	+	1	627	c.627C>T	c.(625-627)GTC>GTT	p.V209V		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						TGGTCACTGTCGGAGGAACAT	0.527			NA											39	146					0	0	0.004289	0	0
PRPF19	27339	broad.mit.edu	37	11	60658701	60658701	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:60658701C>G	uc001nqf.2	-	16	1659	c.1452G>C	c.(1450-1452)GGG>GGC	p.G484G		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	484	WD 7.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						TGGCGTGATGCCCGAAGGCCA	0.542			NA											15	22					0	0	0.004007	0	0
PRPF19	27339	broad.mit.edu	37	11	60666723	60666723	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:60666723G>A	uc001nqf.2	-	11	1089	c.882C>T	c.(880-882)CCC>CCT	p.P294P		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	294	WD 2.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						AAGAGGCATTGGGGACCGACC	0.517			NA									OREG0020994	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	47					0	0	0.008291	0	0
DAK	26007	broad.mit.edu	37	11	61110123	61110123	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:61110123G>A	uc001nre.2	+	9	1025	c.768G>A	c.(766-768)GTG>GTA	p.V256V	DDB1_uc010rlf.1_5'Flank|DAK_uc009ynm.1_Silent_p.V186V	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	256	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						ATGTGCCTGTGCAGCCCGGTG	0.607			NA											21	51					0	0	0.010504	0	0
NRXN2	9379	broad.mit.edu	37	11	64418777	64418777	+	Silent	SNP	C	C	A	rs116802246	by1000genomes	TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:64418777C>A	uc001oar.2	-	15	3307	c.2868G>T	c.(2866-2868)CTG>CTT	p.L956L	NRXN2_uc001oas.2_Silent_p.L916L|NRXN2_uc001oaq.2_Silent_p.L623L	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCGAGTTGAACAGAAGAAGCC	0.592			NA									OREG0004037|OREG0021057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)|type=REGULATORY REGION|Gene=AL137356|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	40					6.49762e-13	8.06962e-13	0.006122	1	0
C11orf30	56946	broad.mit.edu	37	11	76227220	76227220	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:76227220C>G	uc001oxl.2	+	11	1691	c.1548C>G	c.(1546-1548)AGC>AGG	p.S516R	C11orf30_uc001oxm.2_Missense_Mutation_p.S432R|C11orf30_uc010rsb.1_Missense_Mutation_p.S531R|C11orf30_uc010rsc.1_Missense_Mutation_p.S531R|C11orf30_uc001oxn.2_Missense_Mutation_p.S517R|C11orf30_uc010rsd.1_Missense_Mutation_p.S530R	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	516	Thr-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						CAACAGTGAGCCCATCCATTG	0.443			NA											15	89					0	0	0.00499	0	0
ODZ4	26011	broad.mit.edu	37	11	78431415	78431415	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:78431415C>T	uc001ozl.3	-	25	4284	c.3821G>A	c.(3820-3822)AGT>AAT	p.S1274N		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1274	NHL 2.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GTTGGCTTACCTATGTCTGAA	0.443			NA											21	58					0	0	0.014323	0	0
HEPHL1	341208	broad.mit.edu	37	11	93834393	93834393	+	Missense_Mutation	SNP	G	G	A	rs142611571	by1000genomes	TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:93834393G>A	uc001pep.2	+	14	2624	c.2467G>A	c.(2467-2469)GTC>ATC	p.V823I	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	823	Plastocyanin-like 5.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GGGCAACACCGTCCTGATCAT	0.448			NA											20	86					0	0	0.010504	0	0
DSCAML1	57453	broad.mit.edu	37	11	117376278	117376278	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:117376278C>A	uc001prh.1	-	9	2135	c.2133G>T	c.(2131-2133)ATG>ATT	p.M711I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	651	Extracellular (Potential).|Ig-like C2-type 7.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GCAGGGAGCTCATGAATTCCT	0.602			NA											13	42					5.50884e-06	6.17739e-06	0.013537	1	0
IL10RA	3587	broad.mit.edu	37	11	117869812	117869812	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:117869812A>T	uc001prv.2	+	7	1270	c.1193A>T	c.(1192-1194)CAG>CTG	p.Q398L	IL10RA_uc010rxl.1_Missense_Mutation_p.Q378L|IL10RA_uc010rxm.1_Missense_Mutation_p.Q378L|IL10RA_uc010rxn.1_Missense_Mutation_p.Q249L|IL10RA_uc001prw.2_Missense_Mutation_p.Q249L	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	398	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		AGCAGGGGCCAGGATGACAGT	0.647			NA											19	23					0	0	0.010504	0	0
BSX	390259	broad.mit.edu	37	11	122848574	122848574	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:122848574C>T	uc010rzs.1	-	3	485	c.485G>A	c.(484-486)CGG>CAG	p.R162Q		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	162	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		ATGCTTCATCCGCCGGTTCTG	0.532			NA											15	64					0	0	0.00245	0	0
HSPA8	3312	broad.mit.edu	37	11	122930391	122930391	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:122930391C>T	uc001pyo.2	-	5	988	c.910G>A	c.(910-912)GAA>AAA	p.E304K	HSPA8_uc009zbc.2_Missense_Mutation_p.E68K|HSPA8_uc001pyp.2_Missense_Mutation_p.E304K|HSPA8_uc010rzu.1_Missense_Mutation_p.E227K|HSPA8_uc009zbd.1_Missense_Mutation_p.E304K	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	304	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GCATTCAGTTCTTCAAATCGG	0.488	Colon(21;486 594 5900 6733 14272)		NA											13	51					0	0	0.013537	0	0
OR8B8	26493	broad.mit.edu	37	11	124310805	124310805	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:124310805C>A	uc010sal.1	-	1	177	c.177G>T	c.(175-177)ATG>ATT	p.M59I		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GGAAGAAGTACATAGGGGTGT	0.448			NA											7	57					0.000157383	0.000170683	0.00308	1	0
NFRKB	4798	broad.mit.edu	37	11	129746708	129746708	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr11:129746708C>T	uc001qfi.2	-	17	1856	c.1655G>A	c.(1654-1656)GGC>GAC	p.G552D	NFRKB_uc001qfg.2_Missense_Mutation_p.G577D|NFRKB_uc001qfh.2_Missense_Mutation_p.G575D|NFRKB_uc010sbw.1_Missense_Mutation_p.G562D|NFRKB_uc009zcr.2_5'Flank	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	552					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GTCAAACACGCCCTTCACTGG	0.582			NA											30	40					0	0	0.008361	0	0
KCNA6	3742	broad.mit.edu	37	12	4920657	4920657	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:4920657C>T	uc001qng.2	+	1	2316	c.1450C>T	c.(1450-1452)CAG>TAG	p.Q484*		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	484						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CACTTGTGGGCAGCCTGCGCC	0.607			NA								HNSCC(72;0.22)			14	33					0	0	0.00245	0	0
A2ML1	144568	broad.mit.edu	37	12	8995922	8995922	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:8995922G>A	uc001quz.3	+	12	1539	c.1441G>A	c.(1441-1443)GCA>ACA	p.A481T	A2ML1_uc001qva.1_Missense_Mutation_p.A61T|A2ML1_uc010sgm.1_5'Flank	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	325						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						CCCGGCCGATGCAAGCCCTGA	0.562			NA											12	24					0	0	0.010729	0	0
FAM60A	58516	broad.mit.edu	37	12	31440662	31440662	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:31440662T>C	uc010sjz.1	-	5	651	c.412A>G	c.(412-414)AGT>GGT	p.S138G	FAM60A_uc001rkd.2_Missense_Mutation_p.S138G|FAM60A_uc010ska.1_Missense_Mutation_p.S138G|FAM60A_uc001rke.2_Missense_Mutation_p.S138G|FAM60A_uc010skb.1_RNA|FAM60A_uc001rkc.2_Missense_Mutation_p.S163G	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	138											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					GACTGGTTACTGTAACAAGGA	0.378			NA											10	8					0	0	0.008291	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43896082	43896082	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:43896082C>G	uc010skx.1	-	4	740	c.740G>C	c.(739-741)AGA>ACA	p.R247T		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	247						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCTGGAATGTCTTCTTTCATC	0.338			NA											12	42					0	0	0.010729	0	0
SLC4A8	9498	broad.mit.edu	37	12	51856190	51856190	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:51856190G>C	uc001rys.1	+	10	1376	c.1198G>C	c.(1198-1200)GAG>CAG	p.E400Q	SLC4A8_uc010sni.1_Missense_Mutation_p.E347Q|SLC4A8_uc001rym.2_Missense_Mutation_p.E347Q|SLC4A8_uc001ryn.2_Missense_Mutation_p.E347Q|SLC4A8_uc001ryo.2_Missense_Mutation_p.E347Q|SLC4A8_uc001ryp.1_3'UTR|SLC4A8_uc010snj.1_Missense_Mutation_p.E427Q|SLC4A8_uc001ryq.3_Missense_Mutation_p.E400Q|SLC4A8_uc001ryr.2_Missense_Mutation_p.E400Q|SLC4A8_uc010snk.1_Missense_Mutation_p.E347Q	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	400	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		CCCTCCAGGAGAGTGGGATCC	0.493			NA											10	41					0	0	0.008291	0	0
ESYT1	23344	broad.mit.edu	37	12	56536636	56536636	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:56536636C>T	uc001sjq.2	+	27	2956	c.2906C>T	c.(2905-2907)GCC>GTC	p.A969V	ESYT1_uc001sjr.2_Missense_Mutation_p.A979V	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	969						integral to membrane				ovary(4)|skin(1)	5						GAGGCTCCAGCCGGGCCTCTG	0.522			NA											3	48					0	0	0.004672	0	0
SDR9C7	121214	broad.mit.edu	37	12	57327928	57327928	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:57327928G>T	uc010sqw.1	-	1	118	c.118C>A	c.(118-120)CTG>ATG	p.L40M		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,	40	NADP (By similarity).					cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						TTGGCCAGCAGGTTCCCGAAG	0.537			NA											9	18					1.76689e-08	2.06659e-08	0.006214	1	0
GPR182	11318	broad.mit.edu	37	12	57389146	57389146	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:57389146C>A	uc001smk.2	+	2	247	c.153C>A	c.(151-153)ACC>ACA	p.T51T	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	51	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1						GCCAGAGCACCAAGCGCGTGG	0.592			NA											36	70					2.47316e-13	3.10489e-13	0.003271	1	0
STAT6	6778	broad.mit.edu	37	12	57490729	57490729	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:57490729G>A	uc009zpe.2	-	21	2509	c.2258C>T	c.(2257-2259)GCT>GTT	p.A753V	STAT6_uc009zpf.2_Missense_Mutation_p.A753V|STAT6_uc001sna.2_Missense_Mutation_p.A753V|STAT6_uc010srb.1_Missense_Mutation_p.A643V|STAT6_uc010src.1_Missense_Mutation_p.A643V|STAT6_uc010srd.1_Missense_Mutation_p.A643V|STAT6_uc009zpg.2_Missense_Mutation_p.A802V	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	753					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						GCTGGACACAGCATGCTCCTG	0.612			NA											3	51					0	0	0.009096	0	0
INHBE	83729	broad.mit.edu	37	12	57850009	57850009	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:57850009G>T	uc001snw.2	+	2	655	c.431G>T	c.(430-432)CGA>CTA	p.R144L		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	144					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						AGGATCTTCCGATGGGGACCA	0.617	GBM(191;1808 2166 15720 36624 50371)		NA									OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	154					3.80469e-20	5.29448e-20	0.009535	1	0
FRS2	10818	broad.mit.edu	37	12	69967839	69967839	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:69967839A>G	uc001suy.2	+	10	1141	c.631A>G	c.(631-633)AGT>GGT	p.S211G	FRS2_uc001suz.2_Missense_Mutation_p.S211G|FRS2_uc009zrj.2_Missense_Mutation_p.S211G|FRS2_uc009zrk.2_Missense_Mutation_p.S211G	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	211					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAACCGCACAAGTGTGCATGT	0.408			NA											7	44					0	0	0.001984	0	0
TPH2	121278	broad.mit.edu	37	12	72388341	72388341	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:72388341C>A	uc009zrw.1	+	8	1205	c.1064C>A	c.(1063-1065)GCC>GAC	p.A355D	TPH2_uc001swy.2_Missense_Mutation_p.A265D	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	355					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CAGAAACTAGCCACGGTGAGT	0.393			NA											17	15					4.7546e-09	5.66141e-09	0.004007	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85438563	85438563	+	Silent	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:85438563A>G	uc001tac.2	+	4	423	c.312A>G	c.(310-312)GAA>GAG	p.E104E	LRRIQ1_uc001tab.1_Silent_p.E104E|LRRIQ1_uc001taa.1_Silent_p.E104E|LRRIQ1_uc001tad.2_Silent_p.E12E	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	104										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CTGAATATGAAGAAAGTTCAG	0.264			NA											5	12					0	0	0.000602	0	0
FGD6	55785	broad.mit.edu	37	12	95603981	95603981	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:95603981T>A	uc001tdp.3	-	2	1303	c.1079A>T	c.(1078-1080)AAA>ATA	p.K360I	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	360					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						AACACTGATTTTATTGATTTT	0.373			NA											18	45					0	0	0.00499	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100453175	100453175	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:100453175A>C	uc001tgq.2	-	14	2109	c.1880T>G	c.(1879-1881)TTT>TGT	p.F627C	UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.F277C	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	627										ovary(2)	2						AAAGTCTTGAAACAAAGCTTC	0.358			NA											5	25					0	0	0.001168	0	0
ARL1	400	broad.mit.edu	37	12	101790284	101790284	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:101790284G>A	uc001tib.2	-	5	557	c.408C>T	c.(406-408)TCC>TCT	p.S136S	ARL1_uc010svn.1_Silent_p.S90S|ARL1_uc010svo.1_Intron|ARL1_uc001tic.2_Silent_p.S136S	NM_001177	NP_001168	P40616	ARL1_HUMAN	ADP-ribosylation factor-like 1	136					small GTPase mediated signal transduction	Golgi membrane	enzyme activator activity|GTP binding|GTPase activity|metal ion binding|protein binding			central_nervous_system(1)	1		Lung NSC(355;2.1e-05)|Breast(359;0.00015)|Myeloproliferative disorder(1001;0.163)		GBM - Glioblastoma multiforme(134;1.67e-09)|BRCA - Breast invasive adenocarcinoma(302;0.0125)		CCATCTCTGAGGAAGTCATGG	0.413			NA											15	74					0	0	0.00499	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105467760	105467760	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:105467760C>T	uc001tlc.2	-	2	199	c.72G>A	c.(70-72)AAG>AAA	p.K24K	ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	24	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						TTAGTGCCAACTTCAGCTTGT	0.388			NA											15	55					0	0	0.004007	0	0
POLR3B	55703	broad.mit.edu	37	12	106786859	106786859	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:106786859G>T	uc001tlp.2	+	10	996	c.774G>T	c.(772-774)GAG>GAT	p.E258D	POLR3B_uc001tlq.2_Missense_Mutation_p.E200D	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	258				E -> A (in Ref. 1; AAM18214).	innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTGGAACAGAGGAGCACGTGA	0.463			NA											26	62					6.32553e-13	7.89837e-13	0.004656	1	0
ACAD10	80724	broad.mit.edu	37	12	112182571	112182571	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:112182571G>T	uc001tsq.2	+	13	2039	c.1839G>T	c.(1837-1839)CCG>CCT	p.P613P	ACAD10_uc001tsp.2_Silent_p.P613P|ACAD10_uc009zvx.2_Silent_p.P644P|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	613							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						TCACAAATCCGTTAACAAGGT	0.532			NA											19	41					1.67942e-08	1.97931e-08	0.006122	1	0
RASAL1	8437	broad.mit.edu	37	12	113559399	113559399	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:113559399C>A	uc001tum.1	-	6	636	c.343G>T	c.(343-345)GAA>TAA	p.E115*	RASAL1_uc010syp.1_Nonsense_Mutation_p.E115*|RASAL1_uc001tul.2_Nonsense_Mutation_p.E115*|RASAL1_uc001tun.1_Nonsense_Mutation_p.E115*|RASAL1_uc010syq.1_Nonsense_Mutation_p.E115*|RASAL1_uc001tuo.3_Nonsense_Mutation_p.E115*|RASAL1_uc010syr.1_Nonsense_Mutation_p.E115*	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	115					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						CCCTGCACTTCTGCATCTGGG	0.468			NA											4	58					0.00909568	0.00942198	0.009096	1	0
FBXO21	23014	broad.mit.edu	37	12	117595761	117595761	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:117595761C>G	uc001twk.2	-	10	1494	c.1455G>C	c.(1453-1455)GAG>GAC	p.E485D	FBXO21_uc001twj.2_Missense_Mutation_p.E478D|FBXO21_uc009zwq.2_Missense_Mutation_p.E418D|FBXO21_uc001twl.1_Missense_Mutation_p.E98D	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	485					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		CTACGCCCACCTCCTCCTTTT	0.577	GBM(168;452 2038 13535 17701 43680)		NA											33	150					0	0	0.004289	0	0
RAB35	11021	broad.mit.edu	37	12	120546238	120546238	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:120546238G>A	uc001txm.1	-	2	231	c.86C>T	c.(85-87)GCA>GTA	p.A29V	RAB35_uc009zww.1_5'UTR|RAB35_uc010szh.1_Missense_Mutation_p.A29V	NM_006861	NP_006852	Q15286	RAB35_HUMAN	RAB35, member RAS oncogene family	29					cytokinesis|endosome transport|protein transport|small GTPase mediated signal transduction	cell projection membrane|clathrin-coated endocytic vesicle|coated pit|endosome|intercellular bridge|melanosome	GTP binding|GTPase activity|phosphatidylinositol-4,5-bisphosphate binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.248)		AGTGTTGTCTGCAAAACGCAA	0.572			NA											3	27					0	0	0.009096	0	0
RSRC2	65117	broad.mit.edu	37	12	123003488	123003488	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:123003488C>G	uc001ucr.2	-	4	442	c.296G>C	c.(295-297)AGA>ACA	p.R99T	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_Missense_Mutation_p.R40T|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.R51T|RSRC2_uc001ucu.2_Missense_Mutation_p.R99T	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	99	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		TAGTCGCTCTCTTCCTTTATC	0.378			NA											4	152					0	0	0.009096	0	0
DHX37	57647	broad.mit.edu	37	12	125449154	125449154	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:125449154C>G	uc001ugy.2	-	15	1930	c.1831G>C	c.(1831-1833)GAG>CAG	p.E611Q		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	611	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CGAGTCCCCTCCGGTGGAGGC	0.542			NA											5	65					0	0	0.000602	0	0
PIWIL1	9271	broad.mit.edu	37	12	130845802	130845802	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr12:130845802C>A	uc001uik.2	+	15	1833	c.1743C>A	c.(1741-1743)ACC>ACA	p.T581T	PIWIL1_uc001uij.1_Silent_p.T581T	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	581	RNA-binding (By similarity).|Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATTGCCCTACCCCAAGTCAGT	0.453			NA											7	33					5.18039e-06	5.83742e-06	0.00308	1	0
FLT3	2322	broad.mit.edu	37	13	28588591	28588591	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr13:28588591C>T	uc001urw.2	-	23	2939	c.2857G>A	c.(2857-2859)GCG>ACG	p.A953T	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.A912T	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	953	Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.A953V(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTACATACCGCTTCTTCTGCA	0.418			NA	Mis|O		AML|ALL								5	10					0	0	0.001168	0	0
TRPC4	7223	broad.mit.edu	37	13	38211107	38211107	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr13:38211107C>T	uc001uws.2	-	11	3102	c.2867G>A	c.(2866-2868)AGT>AAT	p.S956N	TRPC4_uc010abv.2_Missense_Mutation_p.S536N|TRPC4_uc001uwt.2_Missense_Mutation_p.S872N|TRPC4_uc010tey.1_Missense_Mutation_p.S815N|TRPC4_uc010abw.2_Missense_Mutation_p.S783N|TRPC4_uc010abx.2_Missense_Mutation_p.S961N|TRPC4_uc010aby.2_Missense_Mutation_p.S807N	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	956	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ATAGTCTATACTAGAGTCCTC	0.438			NA											14	22					0	0	0.001855	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455574	84455574	+	Silent	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr13:84455574A>T	uc001vlk.2	-	1	955	c.69T>A	c.(67-69)GTT>GTA	p.V23V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	23	LRRNT.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCTCTTTGCAAACGTCCCCTG	0.473			NA											21	17					0	0	0.014323	0	0
RAP2A	5911	broad.mit.edu	37	13	98086961	98086961	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr13:98086961C>T	uc001vnd.2	+	1	487	c.237C>T	c.(235-237)ATC>ATT	p.I79I		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	79					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			AGGGCTTCATCCTCGTCTACA	0.632			NA											11	49					0	0	0.008291	0	0
OR4M1	441670	broad.mit.edu	37	14	20249415	20249415	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr14:20249415G>T	uc010tku.1	+	1	934	c.934G>T	c.(934-936)GAG>TAG	p.E312*		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTGTGTGAAGAGAAGTGAAA	0.358			NA											8	16					0.00307968	0.00325586	0.00308	1	0
OR10G2	26534	broad.mit.edu	37	14	22102534	22102534	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr14:22102534G>T	uc010tmc.1	-	1	465	c.465C>A	c.(463-465)GTC>GTA	p.V155V		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TGGAGCCGGCGACCCAAGCTC	0.562			NA											33	33					2.85442e-18	3.89009e-18	0.010818	1	0
CMTM5	116173	broad.mit.edu	37	14	23847972	23847972	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr14:23847972C>T	uc010akm.2	+	3	818	c.374C>T	c.(373-375)CCC>CTC	p.P125L	CMTM5_uc001wjs.2_Intron|CMTM5_uc001wjt.2_Intron|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	125	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GGCTTGACCCCCCCGGGCTGG	0.647			NA											4	19					0	0	0.009096	0	0
NFATC4	4776	broad.mit.edu	37	14	24839538	24839538	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr14:24839538C>T	uc001wpc.2	+	2	1255	c.934C>T	c.(934-936)CCT>TCT	p.P312S	NFATC4_uc010tok.1_Missense_Mutation_p.P375S|NFATC4_uc010tol.1_Missense_Mutation_p.P375S|NFATC4_uc010alr.2_Missense_Mutation_p.P375S|NFATC4_uc010als.2_Missense_Mutation_p.P325S|NFATC4_uc010tom.1_Missense_Mutation_p.P325S|NFATC4_uc010ton.1_Missense_Mutation_p.P325S|NFATC4_uc010too.1_Missense_Mutation_p.P325S|NFATC4_uc010alt.2_Missense_Mutation_p.P344S|NFATC4_uc010top.1_Missense_Mutation_p.P344S|NFATC4_uc010toq.1_Missense_Mutation_p.P344S|NFATC4_uc010alu.2_Intron|NFATC4_uc010tor.1_Missense_Mutation_p.P312S|NFATC4_uc010tos.1_Missense_Mutation_p.P242S|NFATC4_uc010tot.1_Missense_Mutation_p.P300S|NFATC4_uc010tou.1_Missense_Mutation_p.P242S|NFATC4_uc010tov.1_Missense_Mutation_p.P300S|NFATC4_uc010tow.1_Missense_Mutation_p.P242S|NFATC4_uc010alv.2_Missense_Mutation_p.P300S|NFATC4_uc010tox.1_Missense_Mutation_p.P242S|NFATC4_uc001wpd.2_5'Flank|NFATC4_uc010toy.1_5'Flank|NFATC4_uc010toz.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	312	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		CCCGGGCTCCCCTGGTCCCTT	0.677			NA											10	42					0	0	0.006214	0	0
BAZ1A	11177	broad.mit.edu	37	14	35262077	35262077	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr14:35262077C>T	uc001wsk.2	-	12	1982	c.1414G>A	c.(1414-1416)GAA>AAA	p.E472K	BAZ1A_uc001wsl.2_Missense_Mutation_p.E472K	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	472	DDT.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		AAAAGCAATTCACACAGTGGG	0.383			NA											7	34					0	0	0.00308	0	0
ANGEL1	23357	broad.mit.edu	37	14	77255719	77255719	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr14:77255719T>C	uc001xsv.2	-	10	1978	c.1865A>G	c.(1864-1866)TAT>TGT	p.Y622C	uc001xsu.1_5'Flank|ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	622										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TCCATCTCGATACAGCCTGTG	0.557			NA											40	24					0	0	0.00623	0	0
C15orf2	23742	broad.mit.edu	37	15	24923368	24923368	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr15:24923368C>A	uc001ywo.2	+	1	2828	c.2354C>A	c.(2353-2355)TCT>TAT	p.S785Y		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	785					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CAGAAAACCTCTCTCCCCAGT	0.547			NA											64	66					8.81991e-31	1.26941e-30	0.01441	1	0
HERC2	8924	broad.mit.edu	37	15	28389852	28389852	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr15:28389852G>C	uc001zbj.2	-	72	11213	c.11107C>G	c.(11107-11109)CGC>GGC	p.R3703G		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3703					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ACGGTGAAGCGCCAGCCCCAG	0.567			NA											11	32					0	0	0.001855	0	0
RPL4	6124	broad.mit.edu	37	15	66795792	66795792	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr15:66795792C>A	uc002apv.2	-	2	135	c.79G>T	c.(79-81)GTA>TTA	p.V27L	RPL4_uc010bhr.2_5'UTR|RPL4_uc002apw.2_5'UTR|RPL4_uc002apx.2_5'UTR|RPL4_uc010ujq.1_Missense_Mutation_p.V27L|SNORD18C_uc010bhs.1_5'Flank|SNORD18B_uc002apy.1_5'Flank|SNORD16_uc010bht.2_5'Flank|SNORD18A_uc002apz.1_5'Flank|ZWILCH_uc010bhu.1_5'Flank|ZWILCH_uc002aqb.2_5'Flank|ZWILCH_uc002aqa.2_5'Flank|ZWILCH_uc010bhv.2_5'Flank	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	27					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						GCCTTGAATACAGCAGGCAAA	0.443			NA											13	21					6.81908e-15	8.89947e-15	0.00245	1	0
C15orf59	388135	broad.mit.edu	37	15	74032288	74032288	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr15:74032288G>T	uc002avy.2	-	2	1197	c.852C>A	c.(850-852)GCC>GCA	p.A284A		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	284										pancreas(1)	1						TCTGTCTAGTGGCTGTGTAGG	0.527			NA											57	97					1.3268e-25	1.8861e-25	0.01441	1	0
FAM173A	65990	broad.mit.edu	37	16	771923	771923	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:771923C>T	uc002cje.2	+	3	507	c.390C>T	c.(388-390)CGC>CGT	p.R130R		NM_023933	NP_076422	Q9BQD7	F173A_HUMAN	hypothetical protein LOC65990	130						integral to membrane				pancreas(1)	1						TCTGCTATCGCCGCAAGGATC	0.721			NA											6	6					0	0	0.001168	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291244	1291244	+	Missense_Mutation	SNP	A	A	G	rs150845192		TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:1291244A>G	uc002ckz.2	+	3	204	c.152A>G	c.(151-153)CAC>CGC	p.H51R	TPSAB1_uc010uux.1_5'UTR	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	51	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				CTGAGAGTCCACGGCCCATAC	0.711			NA											3	52					0	0	0.009096	0	0
TMEM204	79652	broad.mit.edu	37	16	1584550	1584550	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:1584550G>A	uc002cmc.2	+	2	672	c.274G>A	c.(274-276)GTC>ATC	p.V92I	IFT140_uc002clz.2_Intron|IFT140_uc002cmb.2_Intron|TMEM204_uc002cmd.2_Missense_Mutation_p.V92I|TMEM204_uc010brr.1_Missense_Mutation_p.V92I	NM_024600	NP_078876	Q9BSN7	TM204_HUMAN	transmembrane protein 204	92	Extracellular (Potential).				response to stress	adherens junction|integral to membrane					0		Hepatocellular(780;0.219)				CCGAGGCACCGTCAAACGTAA	0.667			NA											22	66					0	0	0.010504	0	0
GRIN2A	2903	broad.mit.edu	37	16	9934621	9934621	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:9934621G>A	uc002czo.3	-	7	2082	c.1534C>T	c.(1534-1536)CTC>TTC	p.L512F	GRIN2A_uc010uym.1_Missense_Mutation_p.L512F|GRIN2A_uc010uyn.1_Missense_Mutation_p.L355F|GRIN2A_uc002czr.3_Missense_Mutation_p.L512F	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	512	Extracellular (Potential).|Glutamate binding (By similarity).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGATGGTGAGCGAGCCAACT	0.443			NA											10	28					0	0	0.008291	0	0
GRIN2A	2903	broad.mit.edu	37	16	10273919	10273919	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:10273919G>A	uc002czo.3	-	2	898	c.350C>T	c.(349-351)TCC>TTC	p.S117F	GRIN2A_uc010uym.1_Missense_Mutation_p.S117F|GRIN2A_uc002czr.3_Missense_Mutation_p.S117F|GRIN2A_uc010buk.2_Missense_Mutation_p.S117F	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	117	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTGTGGGAGGAGATAAAATC	0.607			NA											4	60					0	0	0.009096	0	0
MYH11	4629	broad.mit.edu	37	16	15865511	15865511	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:15865511G>A	uc002ddy.2	-	9	1055	c.948C>T	c.(946-948)CCC>CCT	p.P316P	MYH11_uc002ddv.2_Silent_p.P323P|MYH11_uc002ddw.2_Silent_p.P316P|MYH11_uc002ddx.2_Silent_p.P323P|MYH11_uc010bvg.2_Silent_p.P148P|MYH11_uc002dea.1_Silent_p.P22P	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	316	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CTGCTGGGATGGGCACAAAGC	0.517			NA	T	CBFB	AML								15	41					0	0	0.004007	0	0
XYLT1	64131	broad.mit.edu	37	16	17211698	17211698	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:17211698C>T	uc002dfa.2	-	11	2447	c.2362G>A	c.(2362-2364)GTC>ATC	p.V788I		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	788	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						ATGACATTGACGGGATCCACC	0.572			NA											14	52					0	0	0.001855	0	0
TMC5	79838	broad.mit.edu	37	16	19498557	19498557	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:19498557C>T	uc002dgc.3	+	17	3231	c.2482C>T	c.(2482-2484)CGG>TGG	p.R828W	TMC5_uc010vaq.1_Missense_Mutation_p.R776W|TMC5_uc002dgb.3_Missense_Mutation_p.R828W|TMC5_uc010var.1_Missense_Mutation_p.R828W|TMC5_uc002dgd.1_Missense_Mutation_p.R582W|TMC5_uc002dge.3_Missense_Mutation_p.R582W|TMC5_uc002dgf.3_Missense_Mutation_p.R511W|TMC5_uc002dgg.3_Missense_Mutation_p.R469W	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	828	Extracellular (Potential).					integral to membrane				skin(1)	1						CAAAGCCTGGCGGGCCTCACA	0.567			NA											25	19					0	0	0.00333	0	0
ITGAX	3687	broad.mit.edu	37	16	31372423	31372423	+	Silent	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:31372423T>C	uc002ebu.1	+	9	968	c.901T>C	c.(901-903)TTA>CTA	p.L301L	ITGAX_uc002ebt.2_Silent_p.L301L|ITGAX_uc010vfk.1_5'Flank	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	301	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTGGAAAGAATTAAATGACAT	0.373			NA											3	79					0	0	0.004672	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31485158	31485158	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:31485158C>A	uc002ecd.1	+	4	211	c.185C>A	c.(184-186)ACG>AAG	p.T62K	TGFB1I1_uc002ece.1_Missense_Mutation_p.T45K|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	62	Transcription activation (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						CTTCCCAGCACGGTATGCAAG	0.647			NA											16	84					0.000422831	0.000453244	0.004007	1	0
TOX3	27324	broad.mit.edu	37	16	52497959	52497959	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:52497959C>T	uc002egw.2	-	3	466	c.295G>A	c.(295-297)GGA>AGA	p.G99R	TOX3_uc010vgt.1_Missense_Mutation_p.G94R|TOX3_uc010vgu.1_Missense_Mutation_p.G99R	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	99					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						AATTCACTTCCCTGGGAAGGC	0.532			NA											10	53					0	0	0.008291	0	0
TP53	7157	broad.mit.edu	37	17	7577573	7577573	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:7577573G>T	uc002gim.2	-	7	902	c.708C>A	c.(706-708)TAC>TAA	p.Y236*	TP53_uc002gig.1_Nonsense_Mutation_p.Y236*|TP53_uc002gih.2_Nonsense_Mutation_p.Y236*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Y104*|TP53_uc010cng.1_Nonsense_Mutation_p.Y104*|TP53_uc002gii.1_Nonsense_Mutation_p.Y104*|TP53_uc010cnh.1_Nonsense_Mutation_p.Y236*|TP53_uc010cni.1_Nonsense_Mutation_p.Y236*|TP53_uc002gij.2_Nonsense_Mutation_p.Y236*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.Y143*|TP53_uc002gio.2_Nonsense_Mutation_p.Y104*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	236	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> S (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(46)|p.Y236N(12)|p.Y236H(9)|p.Y236*(9)|p.0?(7)|p.Y236D(6)|p.Y236del(4)|p.Y236S(3)|p.Y236Y(2)|p.Y236fs*4(2)|p.Y236_M237delYM(1)|p.Y236_M237insXX(1)|p.Y236fs*5(1)|p.H233fs*6(1)|p.N235_Y236delNY(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.I232_Y236delIHYNY(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTTACACATGTAGTTGTAGT	0.577	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	14					2.94398e-08	3.42599e-08	0.007413	1	0
Unknown	0	broad.mit.edu	37	17	21731221	21731221	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:21731221A>T	uc002gyy.3	+	2	648	c.523A>T	c.(523-525)ATC>TTC	p.I175F						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						CAGTGACACCATCGAAAATGT	0.547			NA											9	88					0	0	0.006214	0	0
CDK5R1	8851	broad.mit.edu	37	17	30815150	30815150	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:30815150C>G	uc002hhn.2	+	2	733	c.512C>G	c.(511-513)CCC>CGC	p.P171R	CDK5R1_uc010wca.1_Missense_Mutation_p.P171R|CDK5R1_uc010ctc.2_Intron	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	171					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			CACCTGTCCCCCACGGACCCC	0.672			NA											7	75					0	0	0.001984	0	0
PIGW	284098	broad.mit.edu	37	17	34894229	34894229	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:34894229C>T	uc002hmy.1	+	2	1322	c.1279C>T	c.(1279-1281)CTA>TTA	p.L427L	MYO19_uc010wcy.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Silent_p.L427L	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	427					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTCAGAATCTCTAGTCCCTGA	0.343			NA											21	46					0	0	0.008871	0	0
THRA	7067	broad.mit.edu	37	17	38244647	38244647	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:38244647G>T	uc002htw.2	+	8	1359	c.876G>T	c.(874-876)CTG>CTT	p.L292L	THRA_uc010cwp.1_Silent_p.L292L|THRA_uc002htv.2_Silent_p.L292L|THRA_uc002htx.2_Silent_p.L292L	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	292	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	ATGGCGGCCTGGGCGTAGTCT	0.607			NA											28	72					9.39395e-14	1.19231e-13	0.00632	1	0
KRTAP1-3	81850	broad.mit.edu	37	17	39190856	39190856	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:39190856G>A	uc002hvv.2	-	1	252	c.218C>T	c.(217-219)CCA>CTA	p.P73L		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	83			Missing (in allele KAP1.9).			extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGCAGCTTGGCTGGCAGCA	0.607			NA											30	47					0	0	0.007291	0	0
GPATCH8	23131	broad.mit.edu	37	17	42478104	42478104	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:42478104C>A	uc002igw.1	-	8	1405	c.1341G>T	c.(1339-1341)AAG>AAT	p.K447N	GPATCH8_uc002igv.1_Missense_Mutation_p.K369N|GPATCH8_uc010wiz.1_Missense_Mutation_p.K369N	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	447						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TTGCTGCCGCCTTGATGCAGC	0.498			NA									OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	72	130					9.98788e-38	1.44652e-37	0.01441	1	0
PLEKHM1	9842	broad.mit.edu	37	17	43555508	43555508	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:43555508G>C	uc002ija.2	-	3	224	c.54C>G	c.(52-54)ATC>ATG	p.I18M	PLEKHM1_uc010wjm.1_Intron|PLEKHM1_uc002ijb.2_Translation_Start_Site|PLEKHM1_uc010wjn.1_Intron|hsa-mir-4315-1|MI0015844_5'Flank|PLEKHM1_uc002ijd.1_Missense_Mutation_p.I18M	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	18					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					GCTTCTTCTTGATGACCTAGG	0.522			NA											3	74					0	0	0.000602	0	0
ITGB3	3690	broad.mit.edu	37	17	45376752	45376752	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:45376752C>G	uc002ilj.2	+	11	1789	c.1769C>G	c.(1768-1770)ACT>AGT	p.T590S	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	590	Extracellular (Potential).|III.|Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	ACCACGCGTACTGACACCTGC	0.607			NA											46	80					0	0	0.01441	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47123696	47123696	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:47123696G>C	uc002iom.2	+	14	1936	c.1602G>C	c.(1600-1602)CAG>CAC	p.Q534H	IGF2BP1_uc010dbj.2_Missense_Mutation_p.Q395H	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	534	Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).|KH 4.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						AGAACGACCAGGTCATCGTGA	0.557	Esophageal Squamous(198;1041 2123 8248 37119 38268)		NA											17	55					0	0	0.00499	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241556	47241556	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:47241556C>A	uc002ion.2	+	8	1112	c.1053C>A	c.(1051-1053)ACC>ACA	p.T351T	B4GALNT2_uc010wlt.1_Silent_p.T265T|B4GALNT2_uc010wlu.1_Silent_p.T291T	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	351	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			CAGACTTGACCGTAATAGTGG	0.483	GBM(124;244 1635 8663 18097 33175)		NA											55	134					9.59835e-30	1.37715e-29	0.01441	1	0
CACNA1G	8913	broad.mit.edu	37	17	48699156	48699156	+	Splice_Site	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:48699156G>C	uc002irk.1	+	35	6432	c.6060_splice	c.e35+1	p.N2020_splice	CACNA1G_uc002irj.1_Intron|CACNA1G_uc002irl.1_Intron|CACNA1G_uc002irm.1_Intron|CACNA1G_uc002irn.1_Intron|CACNA1G_uc002iro.1_Intron|CACNA1G_uc002irp.1_Intron|CACNA1G_uc002irq.1_Splice_Site_p.N1997_splice|CACNA1G_uc002irr.1_Intron|CACNA1G_uc002irs.1_Intron|CACNA1G_uc002irt.1_Intron|CACNA1G_uc002irv.1_Intron|CACNA1G_uc002irw.1_Splice_Site_p.N1949_splice|CACNA1G_uc002iru.1_Splice_Site_p.N1986_splice|CACNA1G_uc002irx.1_Intron|CACNA1G_uc002iry.1_Intron|CACNA1G_uc002irz.1_Intron|CACNA1G_uc002isa.1_Intron|CACNA1G_uc002isb.1_Intron|CACNA1G_uc002isc.1_Splice_Site_p.N1922_splice|CACNA1G_uc002isd.1_Intron|CACNA1G_uc002ise.1_Intron|CACNA1G_uc002isf.1_Intron|CACNA1G_uc002isg.1_Intron|CACNA1G_uc002ish.1_Intron|CACNA1G_uc002isi.1_Intron	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G						axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGAGAGCAATGTACATACACA	0.607			NA											5	35					0	0	0.000602	0	0
TRIM37	4591	broad.mit.edu	37	17	57109262	57109262	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:57109262G>A	uc002iwy.3	-	18	2387	c.1943C>T	c.(1942-1944)CCC>CTC	p.P648L	TRIM37_uc002iwz.3_Missense_Mutation_p.P648L|TRIM37_uc002ixa.3_Missense_Mutation_p.P526L|TRIM37_uc010woc.1_Missense_Mutation_p.P614L	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	648						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TTTACCTGTGGGCTGCAGAAG	0.373			NA							Mulibrey_Nanism				18	89					0	0	0.00499	0	0
DHX40	79665	broad.mit.edu	37	17	57647936	57647936	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:57647936C>T	uc002ixn.1	+	3	485	c.338C>T	c.(337-339)TCA>TTA	p.S113L	DHX40_uc010woe.1_Intron|DHX40_uc002ixo.1_Missense_Mutation_p.S14L	NM_024612	NP_078888	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	113	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GCTGCTATATCAGTTGCTCAG	0.373			NA											25	84					0	0	0.003954	0	0
KCNH6	81033	broad.mit.edu	37	17	61611628	61611628	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:61611628G>A	uc002jay.2	+	5	1137	c.1057G>A	c.(1057-1059)GCC>ACC	p.A353T	KCNH6_uc002jax.1_Missense_Mutation_p.A353T|KCNH6_uc010wpl.1_Missense_Mutation_p.A230T|KCNH6_uc010wpm.1_Missense_Mutation_p.A353T|KCNH6_uc002jaz.1_Missense_Mutation_p.A353T	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	353	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CATGGTGGCCGCCATCCCTTT	0.622			NA											19	88					0	0	0.006122	0	0
HELZ	9931	broad.mit.edu	37	17	65104710	65104710	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:65104710T>C	uc010wqk.1	-	30	4812	c.4625A>G	c.(4624-4626)CAG>CGG	p.Q1542R	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.Q1541R|HELZ_uc010der.2_Missense_Mutation_p.Q85R	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGGAAGATGCTGGAGGTGAGG	0.582			NA											22	62					0	0	0.010504	0	0
DNAI2	64446	broad.mit.edu	37	17	72278023	72278023	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr17:72278023C>A	uc002jkf.2	+	2	166	c.67C>A	c.(67-69)CGC>AGC	p.R23S	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	23					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						TTTCTCGGACCGCCAGGCCGA	0.617			NA							Kartagener_syndrome				49	62					4.18559e-23	5.93172e-23	0.01441	1	0
MYOM1	8736	broad.mit.edu	37	18	3067287	3067287	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr18:3067287G>T	uc002klp.2	-	38	5365	c.5031C>A	c.(5029-5031)TCC>TCA	p.S1677S	MYOM1_uc002klq.2_Silent_p.S1581S	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1677						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CACCTTTCAGGGACTCCAAGG	0.587			NA											14	12					9.31168e-06	1.03913e-05	0.001855	1	0
MPPE1	65258	broad.mit.edu	37	18	11889438	11889438	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr18:11889438G>A	uc002kqf.2	-	5	1083	c.442C>T	c.(442-444)CAT>TAT	p.H148Y	MPPE1_uc002kqn.2_Missense_Mutation_p.H148Y|MPPE1_uc002kqg.2_RNA|MPPE1_uc002kqh.2_RNA|MPPE1_uc002kqi.2_RNA|MPPE1_uc002kqj.2_Missense_Mutation_p.H148Y|MPPE1_uc002kqk.2_Missense_Mutation_p.H148Y|MPPE1_uc002kql.2_Missense_Mutation_p.H148Y|MPPE1_uc002kqm.2_Missense_Mutation_p.H148Y|MPPE1_uc010dla.1_Missense_Mutation_p.H148Y	NM_023075	NP_075563	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1 precursor	148					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0						AGCTGTACATGACTTGGGTGT	0.483			NA											13	32					0	0	0.013537	0	0
ADNP2	22850	broad.mit.edu	37	18	77894189	77894189	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr18:77894189A>G	uc002lnw.2	+	4	1348	c.893A>G	c.(892-894)CAG>CGG	p.Q298R		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	298	Pro-rich.				cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GCTTTGCCACAGAACAGTCCA	0.602			NA											19	44					0	0	0.010504	0	0
ODF3L2	284451	broad.mit.edu	37	19	463978	463978	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:463978C>A	uc002lor.2	-	4	972	c.736G>T	c.(736-738)GAG>TAG	p.E246*	SHC2_uc002loq.3_5'Flank|ODF3L2_uc010drp.2_Nonsense_Mutation_p.E210*	NM_182577	NP_872383	Q3SX64	OD3L2_HUMAN	outer dense fiber of sperm tails 3-like 2	246	DUF1309 3.										0						GTGACCTGCTCTGGGCAGTGG	0.612			NA											10	13					2.17888e-05	2.42564e-05	0.006214	1	0
MUC16	94025	broad.mit.edu	37	19	9009600	9009600	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:9009600G>T	uc002mkp.2	-	39	39330	c.39126C>A	c.(39124-39126)GTC>GTA	p.V13042V	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13044	Extracellular (Potential).|SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACCCTGCAGGACCCTCTCTG	0.552			NA											17	59					3.41278e-10	4.13833e-10	0.00499	1	0
MUC16	94025	broad.mit.edu	37	19	9065356	9065356	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:9065356G>C	uc002mkp.2	-	3	22294	c.22090C>G	c.(22090-22092)CAC>GAC	p.H7364D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7366	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATCTCTGAGTGTGGCAATCTC	0.507			NA											10	25					0	0	0.006214	0	0
RAVER1	125950	broad.mit.edu	37	19	10439672	10439672	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:10439672C>T	uc002moa.2	-	3	533	c.453G>A	c.(451-453)CTG>CTA	p.L151L		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	134	RRM 2.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TGGCCACACACAGCAGGGCAT	0.657			NA											3	6					0	0	0.004672	0	0
ZNF98	148198	broad.mit.edu	37	19	22575653	22575653	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:22575653G>T	uc002nqt.2	-	4	506	c.384C>A	c.(382-384)AGC>AGA	p.S128R		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				ACTCATCCATGCTTTTACAGT	0.323			NA											5	18					3.59834e-05	3.96762e-05	0.001168	1	0
ZNF99	7652	broad.mit.edu	37	19	22941422	22941422	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:22941422C>T	uc010xrh.1	-	5	1016	c.1016G>A	c.(1015-1017)TGT>TAT	p.C339Y		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGCTTTGCCACATTCTTCACA	0.368			NA											12	25					0	0	0.010729	0	0
ZFP14	57677	broad.mit.edu	37	19	36831589	36831589	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:36831589C>T	uc002odx.1	-	4	1232	c.1139G>A	c.(1138-1140)AGA>AAA	p.R380K	ZFP14_uc010xtd.1_Missense_Mutation_p.R381K|ZFP14_uc010eex.1_Missense_Mutation_p.R380K	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	380	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TAGTTGTTGTCTTAATCTAAA	0.373			NA											21	35					0	0	0.012319	0	0
LGALS14	56891	broad.mit.edu	37	19	40199884	40199884	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:40199884G>T	uc002omg.2	+	4	574	c.351G>T	c.(349-351)CCG>CCT	p.P117P	LGALS14_uc002omf.2_Silent_p.P146P	NM_020129	NP_064514	Q8TCE9	PPL13_HUMAN	lectin, galactoside-binding, soluble, 14 isoform	117	Galectin.					nucleus	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;4.39e-06)|all_lung(34;6.76e-08)|Lung NSC(34;7.98e-08)|Ovarian(47;0.06)	Myeloproliferative disorder(2;0.0741)	Epithelial(26;1.08e-24)|OV - Ovarian serous cystadenocarcinoma(5;1.92e-24)|all cancers(26;4.12e-22)			ATCGATTCCCGCCAGCATCTG	0.458			NA											11	37					3.07112e-06	3.47759e-06	0.010729	1	0
MEGF8	1954	broad.mit.edu	37	19	42853681	42853681	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:42853681G>A	uc002otl.3	+	13	2763	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K	MEGF8_uc002otm.3_Missense_Mutation_p.E318K	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	777	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GGCTCATCAGGAGAAGGAGAC	0.637			NA											8	25					0	0	0.00308	0	0
IRGC	56269	broad.mit.edu	37	19	44224056	44224056	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:44224056A>T	uc002oxh.2	+	2	1493	c.1346A>T	c.(1345-1347)AAG>ATG	p.K449M		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	449						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CTCCTTCTTAAGTACATTCTG	0.557	Colon(189;350 2037 11447 13433 38914)		NA											18	30					0	0	0.007413	0	0
ZNF222	7673	broad.mit.edu	37	19	44536246	44536246	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:44536246C>G	uc002oyc.2	+	4	602	c.419C>G	c.(418-420)TCA>TGA	p.S140*	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Nonsense_Mutation_p.S180*|ZNF222_uc002oyd.2_Nonsense_Mutation_p.S86*	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				CAGTTATATTCAGGAGAGAAG	0.403			NA											23	72					0	0	0.012319	0	0
BCAM	4059	broad.mit.edu	37	19	45322414	45322414	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:45322414G>T	uc002ozu.2	+	11	1482	c.1438G>T	c.(1438-1440)GAC>TAC	p.D480Y	BCAM_uc002ozt.1_Missense_Mutation_p.D480Y	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	480	Extracellular (Potential).|Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CGGCCATCCAGACCCCAAACT	0.592			NA											23	77					2.52088e-20	3.51857e-20	0.00278	1	0
PTGIR	5739	broad.mit.edu	37	19	47124810	47124810	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:47124810G>T	uc002pex.2	-	3	1001	c.888C>A	c.(886-888)CGC>CGA	p.R296R		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	296	Cytoplasmic (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	AGACAGCCTTGCGGAAAAGGA	0.632			NA											19	29					3.99206e-14	5.13741e-14	0.007413	1	0
ZNF534	147658	broad.mit.edu	37	19	52938390	52938390	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:52938390T>C	uc002pzk.2	+	3	299	c.238T>C	c.(238-240)TGG>CGG	p.W80R	ZNF534_uc002pzj.1_Missense_Mutation_p.W67R|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.W67R	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	80	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGATCCCTGGACTCTGCA	0.463			NA											7	20					0	0	0.00308	0	0
ZNF160	90338	broad.mit.edu	37	19	53572747	53572747	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:53572747C>T	uc010eqk.2	-	7	1456	c.1040G>A	c.(1039-1041)GGA>GAA	p.G347E	ZNF160_uc002qaq.3_Missense_Mutation_p.G347E|ZNF160_uc002qar.3_Missense_Mutation_p.G347E	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	347	C2H2-type 4.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AAAGGCTTTTCCACACTCATT	0.403			NA											15	51					0	0	0.003163	0	0
CACNG6	59285	broad.mit.edu	37	19	54502940	54502940	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:54502940C>A	uc002qct.2	+	3	1049	c.459C>A	c.(457-459)GCC>GCA	p.A153A	CACNG6_uc002qcu.2_Intron|CACNG6_uc002qcv.2_Intron	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	153	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CAGTCATGGCCTTGGGGTGCC	0.567			NA											110	127					3.60008e-62	5.2468e-62	0.01441	1	0
LILRB2	10288	broad.mit.edu	37	19	54783278	54783278	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:54783278G>A	uc002qfb.2	-	5	846	c.580C>T	c.(580-582)CAC>TAC	p.H194Y	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.H194Y|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.H194Y|LILRB2_uc010yet.1_Missense_Mutation_p.H78Y|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	194	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TAGCACCTGTGCGACCACCTG	0.582			NA											30	78					0	0	0.009535	0	0
ZNF581	51545	broad.mit.edu	37	19	56156247	56156247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:56156247C>T	uc002qln.2	+	2	1026	c.310C>T	c.(310-312)CGA>TGA	p.R104*	ZNF581_uc002qlq.2_Nonsense_Mutation_p.R104*|CCDC106_uc002qlr.2_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	104	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CTACCTTCAGCGACACAGCAT	0.587			NA											23	71					0	0	0.00333	0	0
ZNF835	90485	broad.mit.edu	37	19	57176525	57176525	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:57176525C>T	uc010ygo.1	-	2	108	c.108G>A	c.(106-108)TTG>TTA	p.L36L	ZNF835_uc010ygn.1_Silent_p.L14L	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						AGTTTCCTTCCAACTCTGCGC	0.572			NA											12	30					0	0	0.010729	0	0
ZNF256	10172	broad.mit.edu	37	19	58453016	58453016	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:58453016G>T	uc002qqu.2	-	3	1395	c.1160C>A	c.(1159-1161)TCC>TAC	p.S387Y	ZNF256_uc010euj.2_Missense_Mutation_p.S234Y	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	387	C2H2-type 7.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		CTGGCTAAAGGATTTCCCACA	0.413	NSCLC(55;1313 1552 8040 11996)		NA											8	38					0.00307968	0.00325586	0.00308	1	0
ZNF606	80095	broad.mit.edu	37	19	58490876	58490876	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:58490876G>C	uc002qqw.2	-	7	1790	c.1172C>G	c.(1171-1173)ACA>AGA	p.T391R	ZNF606_uc010yhp.1_Missense_Mutation_p.T301R	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		GTAAGTGCTTGTATGTTGAGT	0.373			NA											11	53					0	0	0.008291	0	0
SLC27A5	10998	broad.mit.edu	37	19	59022759	59022759	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr19:59022759C>G	uc002qtc.2	-	1	674	c.564G>C	c.(562-564)CTG>CTC	p.L188L		NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	188	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GCCACATACACAGGGCTGGAA	0.687			NA											8	7					0	0	0.00308	0	0
RRM2	6241	broad.mit.edu	37	2	10263558	10263558	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:10263558G>A	uc002rah.2	+	3	410	c.219G>A	c.(217-219)CTG>CTA	p.L73L		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	73					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		AGCCGCTGCTGAGAGAAAACC	0.517			NA											14	49					0	0	0.00245	0	0
GREB1	9687	broad.mit.edu	37	2	11758583	11758583	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:11758583C>G	uc002rbk.1	+	22	3882	c.3582C>G	c.(3580-3582)CCC>CCG	p.P1194P	GREB1_uc002rbp.1_Silent_p.P192P	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1194	Ser-rich.					integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GGCACAGTCCCGGGCCGACGC	0.716	Ovarian(39;850 945 2785 23371 33093)		NA											4	9					0	0	0.009096	0	0
EHD3	30845	broad.mit.edu	37	2	31489255	31489255	+	Silent	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:31489255A>T	uc002rnu.2	+	6	1901	c.1293A>T	c.(1291-1293)GGA>GGT	p.G431G	EHD3_uc010ymt.1_3'UTR	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	431					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					AGGGGGCTGGAGAAGGTATCG	0.627			NA											15	24					0	0	0.003163	0	0
EHBP1	23301	broad.mit.edu	37	2	63176238	63176238	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:63176238G>A	uc002sby.2	+	14	2844	c.2362G>A	c.(2362-2364)GAT>AAT	p.D788N	EHBP1_uc010fcp.2_Missense_Mutation_p.D753N|EHBP1_uc002sbz.2_Missense_Mutation_p.D753N|EHBP1_uc002scb.2_Missense_Mutation_p.D753N	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	788						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GACGGAGTCTGATCCAGATGC	0.353			NA							Hereditary_Prostate_Cancer				15	32					0	0	0.00245	0	0
GFPT1	2673	broad.mit.edu	37	2	69565628	69565628	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:69565628T>A	uc002sfh.2	-	13	1398	c.1219A>T	c.(1219-1221)AGA>TGA	p.R407*		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	425	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						GGTGTGTTTCTGTCCAGGAAG	0.398			NA											6	25					0	0	0.001168	0	0
FBXO41	150726	broad.mit.edu	37	2	73491152	73491152	+	Silent	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:73491152G>C	uc002sjb.1	-	7	2019	c.2019C>G	c.(2017-2019)ACC>ACG	p.T673T		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	612						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						AGTGGGCCTGGGTGCACCACT	0.627			NA											5	4					0	0	0.000602	0	0
SEMA4C	54910	broad.mit.edu	37	2	97526514	97526514	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:97526514G>C	uc002sxh.3	-	15	2511	c.2351C>G	c.(2350-2352)TCA>TGA	p.S784*	ANKRD39_uc002sxd.3_5'Flank|SEMA4C_uc002sxf.3_Nonsense_Mutation_p.S284*|SEMA4C_uc002sxe.2_Nonsense_Mutation_p.S325*|SEMA4C_uc002sxg.3_Nonsense_Mutation_p.S837*	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	784	Cytoplasmic (Potential).				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						ATTGGCATTTGAGTTCCGCCC	0.667			NA											36	73					0	0	0.005524	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107423166	107423166	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:107423166G>T	uc002tdq.2	-	6	1677	c.1558C>A	c.(1558-1560)CCT>ACT	p.P520T	ST6GAL2_uc002tdr.2_Missense_Mutation_p.P520T	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	520	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CTTGGTGCAGGGCAGTGCACC	0.507			NA											30	59					8.4185e-14	1.07738e-13	0.012213	1	0
GYPC	2995	broad.mit.edu	37	2	127453545	127453545	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:127453545G>T	uc002tnq.2	+	4	370	c.214G>T	c.(214-216)GTC>TTC	p.V72F	GYPC_uc002tnr.2_Missense_Mutation_p.V53F|GYPC_uc010flv.2_RNA	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1	72	Helical; Signal-anchor for type III membrane protein.					cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		TGTGGCCATCGTCCTAGTCTC	0.607	Melanoma(110;806 1600 6704 9981 33404)		NA											27	90					1.77063e-15	2.32395e-15	0.005443	1	0
ARHGAP15	55843	broad.mit.edu	37	2	144381787	144381787	+	Silent	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:144381787T>A	uc002tvm.3	+	12	1240	c.1089T>A	c.(1087-1089)CCT>CCA	p.P363P	ARHGAP15_uc002tvn.2_Silent_p.P129P	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	363	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		GGGAGCTGCCTGAGCCGCTCT	0.507			NA											20	16					0	0	0.010504	0	0
GALNT5	11227	broad.mit.edu	37	2	158115703	158115703	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:158115703C>T	uc002tzg.2	+	1	1364	c.1109C>T	c.(1108-1110)TCA>TTA	p.S370L	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	370	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						TCTTCCTCTTCACTTGCTCCA	0.413			NA											18	30					0	0	0.00499	0	0
UPP2	151531	broad.mit.edu	37	2	158974356	158974356	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:158974356C>A	uc002tzp.2	+	4	554	c.360C>A	c.(358-360)TCC>TCA	p.S120S	UPP2_uc002tzo.2_Silent_p.S177S	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	120					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						GCATCCCCTCCATTTCTATTA	0.418			NA											24	75					1.64293e-13	2.06822e-13	0.00333	1	0
KCNH7	90134	broad.mit.edu	37	2	163241415	163241415	+	Silent	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:163241415A>G	uc002uch.1	-	13	2957	c.2745T>C	c.(2743-2745)GAT>GAC	p.D915D		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	915	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	GTCTTATGGTATCTGCAGAGT	0.353	GBM(196;1492 2208 17507 24132 45496)		NA											7	48					0	0	0.001984	0	0
HOXD12	3238	broad.mit.edu	37	2	176965464	176965465	+	Nonsense_Mutation	DNP	GG	GG	AT			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:176965464_176965465GG>AT	uc010zev.1	+	2	789_790	c.789_790GG>AT	c.(787-792)CGGGAG>CGATAG	p.E264*	HOXD12_uc010zew.1_3'UTR	NM_021193	NP_067016	P35452	HXD12_HUMAN	homeobox D12	264						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		TGGTGCTTCGGGAGCAGGCGCT	0.589			NA											4	8					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179467165	179467165	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:179467165C>G	uc010zfg.1	-	232	47484	c.47260G>C	c.(47260-47262)GTA>CTA	p.V15754L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V9449L|TTN_uc010zfi.1_Missense_Mutation_p.V9382L|TTN_uc010zfj.1_Missense_Mutation_p.V9257L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16681							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTCATTTACTCTTTTCCAG	0.423			NA											10	29					0	0	0.008291	0	0
ITGA4	3676	broad.mit.edu	37	2	182387061	182387061	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:182387061T>C	uc002unu.2	+	18	2829	c.2066T>C	c.(2065-2067)TTA>TCA	p.L689S	ITGA4_uc010frj.1_Missense_Mutation_p.L171S|ITGA4_uc002unv.2_5'UTR	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	689	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATTAAGATTTTAGAGCTGGTA	0.338			NA											25	15					0	0	0.004656	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174788	207174788	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:207174788C>T	uc002vbp.2	+	5	5786	c.5536C>T	c.(5536-5538)CTG>TTG	p.L1846L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1846							nucleic acid binding|zinc ion binding			ovary(3)	3						AATTAATGCTCTGGTGAAGGA	0.413			NA											13	23					0	0	0.013537	0	0
DYTN	391475	broad.mit.edu	37	2	207564891	207564892	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:207564891_207564892GC>AA	uc002vbr.1	-	6	649_650	c.532_533GC>TT	c.(532-534)GCC>TTC	p.A178F		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	178						plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		GCTGCGGGTGGCACTTTCCACA	0.5			NA											6	50					0	0	0.004672	0	0
STK11IP	114790	broad.mit.edu	37	2	220478566	220478566	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:220478566G>C	uc002vml.2	+	21	2706	c.2663G>C	c.(2662-2664)CGG>CCG	p.R888P		NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	888					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGAGCCTGCGGCTAGAGTGG	0.667			NA											11	44					0	0	0.008291	0	0
C2orf57	165100	broad.mit.edu	37	2	232458229	232458229	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:232458229C>T	uc002vrz.2	+	1	618	c.567C>T	c.(565-567)ACC>ACT	p.T189T		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	189										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		CTGCCAGCACCACCAAGTCTG	0.582			NA											34	27					0	0	0.013726	0	0
ALPI	248	broad.mit.edu	37	2	233323045	233323045	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:233323045G>A	uc002vst.3	+	9	1187	c.1110G>A	c.(1108-1110)CTG>CTA	p.L370L	ALPI_uc002vsu.3_Silent_p.L281L	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	370					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		AGGACACGCTGACCCTCGTCA	0.617			NA											9	29					0	0	0.004482	0	0
DGKD	8527	broad.mit.edu	37	2	234359623	234359623	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:234359623T>G	uc002vui.1	+	17	2106	c.2094T>G	c.(2092-2094)AGT>AGG	p.S698R	DGKD_uc002vuj.1_Missense_Mutation_p.S654R|DGKD_uc010fyh.1_Missense_Mutation_p.S565R|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	698					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CCCTAGGCAGTTCTGCTTCCC	0.567			NA											44	60					0	0	0.009718	0	0
INSM1	3642	broad.mit.edu	37	20	20350422	20350422	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr20:20350422T>C	uc002wrx.2	+	1	1658	c.1511T>C	c.(1510-1512)GTG>GCG	p.V504A		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	504					endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		CTCCTGCAGGTGCCCGTGCGC	0.657			NA											5	24					0	0	0.000602	0	0
TGIF2	60436	broad.mit.edu	37	20	35219609	35219609	+	Silent	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr20:35219609A>G	uc002xfn.2	+	3	662	c.489A>G	c.(487-489)ACA>ACG	p.T163T	C20orf24_uc002xfo.2_Intron	NM_021809	NP_068581	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	163	Repressive function.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)|skin(1)	2	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CTGGTAGCACACTTACTCTGC	0.627			NA											18	63					0	0	0.00499	0	0
PREX1	57580	broad.mit.edu	37	20	47317347	47317347	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr20:47317347C>A	uc002xtw.1	-	7	884	c.861G>T	c.(859-861)CAG>CAT	p.Q287H		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	287	PH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGGCCCTTTCCTGGATGTTGC	0.562			NA											41	109					2.95478e-19	4.08715e-19	0.00874	1	0
ZFP64	55734	broad.mit.edu	37	20	50768964	50768964	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr20:50768964C>G	uc002xwl.2	-	6	2116	c.1767G>C	c.(1765-1767)ACG>ACC	p.T589T	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Silent_p.T587T|ZFP64_uc002xwn.2_Silent_p.T535T	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CACCTGAGGCCGTGGGGATGA	0.597			NA											24	34					0	0	0.00333	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870753	51870753	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr20:51870753C>A	uc002xwo.2	+	2	1712	c.756C>A	c.(754-756)CCC>CCA	p.P252P		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	252					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGCTCAGACCCACGAGCTATT	0.483			NA											9	29					0.00448238	0.00471722	0.004482	1	0
CHRNA4	1137	broad.mit.edu	37	20	61982135	61982135	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr20:61982135C>A	uc002yes.2	-	5	806	c.628G>T	c.(628-630)GTC>TTC	p.V210F	CHRNA4_uc002yet.1_Missense_Mutation_p.V34F|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.V139F|CHRNA4_uc002yev.1_Missense_Mutation_p.V34F|CHRNA4_uc010gkf.1_Missense_Mutation_p.V34F	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	210	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCCACGATGACCCACTCGCCA	0.597			NA											19	43					1.28384e-07	1.49029e-07	0.012319	1	0
CYYR1	116159	broad.mit.edu	37	21	27852738	27852738	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr21:27852738T>A	uc002ymd.2	-	3	509	c.187A>T	c.(187-189)ATT>TTT	p.I63F	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Missense_Mutation_p.I63F	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	63	Helical; (Potential).					integral to membrane					0						ATGCCCGCAATTGCAGTGCCC	0.423			NA											7	48					0	0	0.001984	0	0
MORC3	23515	broad.mit.edu	37	21	37741749	37741749	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr21:37741749C>T	uc002yvi.2	+	15	2159	c.2083C>T	c.(2083-2085)CAA>TAA	p.Q695*		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	695	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						TGCAGGCTGCCAATTACAAGA	0.398			NA											20	20					0	0	0.007413	0	0
ETS2	2114	broad.mit.edu	37	21	40191522	40191522	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr21:40191522C>T	uc002yxg.2	+	8	1103	c.907C>T	c.(907-909)CTG>TTG	p.L303L	ETS2_uc002yxf.2_Silent_p.L443L	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	303					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				GTCGTCCTTGCTGGATGTGCA	0.557			NA											16	17					0	0	0.003163	0	0
PKNOX1	5316	broad.mit.edu	37	21	44438242	44438242	+	Splice_Site	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr21:44438242G>T	uc002zcq.1	+	7	811	c.623_splice	c.e7-1	p.G208_splice	PKNOX1_uc002zcp.1_Splice_Site_p.G208_splice|PKNOX1_uc011aex.1_Splice_Site_p.G91_splice	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1								sequence-specific DNA binding			large_intestine(2)	2						TCCCTTTCGAGGTGGCACAGT	0.383			NA											25	16					5.35047e-06	6.0144e-06	0.00333	1	0
C22orf36	388886	broad.mit.edu	37	22	24981999	24981999	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:24981999C>T	uc003aaq.2	-	4	832	c.803G>A	c.(802-804)AGC>AAC	p.S268N	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_RNA|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	268											0						GGTGCGCTGGCTCAGCCGCCG	0.687			NA											16	66					0	0	0.003163	0	0
SLC35E4	339665	broad.mit.edu	37	22	31032948	31032948	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:31032948T>C	uc003ais.1	+	1	1156	c.511T>C	c.(511-513)TGC>CGC	p.C171R	SLC35E4_uc003ait.2_Missense_Mutation_p.C159R	NM_001001479	NP_001001479	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	171	DUF6.|Leu-rich.					integral to membrane					0						GGGTCCGCTCTGCCTGGGGGC	0.687			NA											3	31					0	0	0.004672	0	0
DEPDC5	9681	broad.mit.edu	37	22	32188070	32188070	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:32188070T>A	uc003als.2	+	11	818	c.676T>A	c.(676-678)TAT>AAT	p.Y226N	DEPDC5_uc011als.1_Missense_Mutation_p.Y226N|DEPDC5_uc011alu.1_Missense_Mutation_p.Y226N|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.Y226N|DEPDC5_uc003alr.1_Missense_Mutation_p.Y226N|DEPDC5_uc011alt.1_Missense_Mutation_p.Y198N	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	226					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TAGAACTTTCTATGATGCAAA	0.388			NA											16	17					0	0	0.004007	0	0
DEPDC5	9681	broad.mit.edu	37	22	32239157	32239157	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:32239157G>T	uc003als.2	+	28	2707	c.2565G>T	c.(2563-2565)ACG>ACT	p.T855T	DEPDC5_uc011als.1_Silent_p.T786T|DEPDC5_uc011alu.1_Silent_p.T864T|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Silent_p.T855T|DEPDC5_uc003alu.2_Silent_p.T304T|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Silent_p.T185T|DEPDC5_uc003alw.2_Silent_p.T153T|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_5'Flank	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	855					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						ACAAAGTGACGCTGAAGGATA	0.433			NA											17	26					3.41278e-10	4.13833e-10	0.00499	1	0
TOB2	10766	broad.mit.edu	37	22	41833088	41833088	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:41833088C>T	uc003azz.1	-	2	969	c.262G>A	c.(262-264)GAG>AAG	p.E88K		NM_016272	NP_057356	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	88					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1						CTCAGCTCCTCAGGCACATTG	0.592			NA											16	112					0	0	0.004007	0	0
ACO2	50	broad.mit.edu	37	22	41913580	41913580	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:41913580C>T	uc003bac.2	+	7	907	c.885C>T	c.(883-885)TCC>TCT	p.S295S	ACO2_uc003bad.2_Silent_p.S320S	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	295					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CCACCACTTCCGTGTTCCCTT	0.622			NA									OREG0026588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	47					0	0	0.009096	0	0
MPPED1	758	broad.mit.edu	37	22	43831029	43831029	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:43831029G>T	uc011apv.1	+	3	523	c.300G>T	c.(298-300)TCG>TCT	p.S100S	MPPED1_uc011apw.1_5'UTR|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Silent_p.S100S|MPPED1_uc011apz.1_Silent_p.S133S	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	100							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				ATACCCACTCGAGGACGGACC	0.627			NA											44	82					9.84934e-19	1.35027e-18	0.010771	1	0
CELSR1	9620	broad.mit.edu	37	22	46860009	46860009	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr22:46860009C>T	uc003bhw.1	-	2	3778	c.3778G>A	c.(3778-3780)GTG>ATG	p.V1260M		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1260	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GAGAAGGTCACGTTCAGGATG	0.637			NA											13	56					0	0	0.001855	0	0
FBLN2	2199	broad.mit.edu	37	3	13670462	13670462	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:13670462A>G	uc011avb.1	+	11	2611	c.2486A>G	c.(2485-2487)AAC>AGC	p.N829S	FBLN2_uc011auz.1_Missense_Mutation_p.N855S|FBLN2_uc011ava.1_Missense_Mutation_p.N876S|FBLN2_uc011avc.1_Missense_Mutation_p.N876S	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	829	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGCTGCATCAACACGGTGGGC	0.632			NA											4	9					0	0	0.009096	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307243	39307243	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:39307243A>T	uc003cjl.2	-	2	850	c.758T>A	c.(757-759)CTG>CAG	p.L253Q		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	253	Helical; Name=6; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		AAGCGTCTCCAGGAAAATCAT	0.468			NA											37	23					0	0	0.005524	0	0
CACNA1D	776	broad.mit.edu	37	3	53757478	53757478	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:53757478C>T	uc003dgv.3	+	13	1847	c.1684C>T	c.(1684-1686)CTC>TTC	p.L562F	CACNA1D_uc003dgu.3_Missense_Mutation_p.L582F|CACNA1D_uc003dgy.3_Missense_Mutation_p.L562F|CACNA1D_uc003dgw.3_Missense_Mutation_p.L229F	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	562	II.|Helical; Name=S2 of repeat II; (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CAACAAAGTCCTCTTGGCTCT	0.512			NA											17	31					0	0	0.006122	0	0
CADM2	253559	broad.mit.edu	37	3	86010666	86010666	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:86010666C>A	uc003dqj.2	+	7	1438	c.812C>A	c.(811-813)CCT>CAT	p.P271H	CADM2_uc003dqk.2_Missense_Mutation_p.P280H|CADM2_uc003dql.2_Missense_Mutation_p.P273H	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	271	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TTACCAGATCCTGACCGAATG	0.403			NA											17	33					6.44725e-10	7.7771e-10	0.014323	1	0
CD200R1L	344807	broad.mit.edu	37	3	112538705	112538705	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:112538705C>A	uc003dzi.1	-	5	943	c.717G>T	c.(715-717)CTG>CTT	p.L239L	CD200R1L_uc011bhw.1_Silent_p.L218L|CD200R1L_uc010hqf.1_Silent_p.L218L	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2	239	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1						AAAGAATGATCAGTAAGGACA	0.388			NA											11	32					1.58986e-06	1.81362e-06	0.008291	1	0
SEMA5B	54437	broad.mit.edu	37	3	122631807	122631807	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:122631807C>G	uc003efz.1	-	18	2912	c.2608G>C	c.(2608-2610)GAG>CAG	p.E870Q	SEMA5B_uc011bju.1_Missense_Mutation_p.E812Q|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.E870Q|SEMA5B_uc003efy.1_5'Flank	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	870	Extracellular (Potential).|TSP type-1 3.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		AAGCCCAGCTCGCAGTCCCGG	0.726			NA											9	37					0	0	0.004482	0	0
PDIA5	10954	broad.mit.edu	37	3	122849399	122849399	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:122849399C>T	uc003egc.1	+	11	902	c.846C>T	c.(844-846)ACC>ACT	p.T282T	PDIA5_uc003egd.1_Intron	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	282	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		ATCACCTGACCGATGAAGACT	0.582			NA											12	62					0	0	0.010729	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135721990	135721990	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:135721990C>G	uc003eqv.1	+	2	2215	c.1650C>G	c.(1648-1650)ACC>ACG	p.T550T	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	550					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CCGGTCAGACCCTTGTAGATC	0.388			NA											7	23					0	0	0.001984	0	0
PRR23C	389152	broad.mit.edu	37	3	138762829	138762829	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:138762829G>A	uc011bmt.1	-	1	906	c.634C>T	c.(634-636)CGC>TGC	p.R212C		NM_001134657	NP_001128129	Q6ZRP0	PR23C_HUMAN	proline rich 23C	212	Pro-rich.									skin(1)	1						AAGATGGGGCGTGGAGAGCGT	0.647			NA											10	11					0	0	0.006214	0	0
XRN1	54464	broad.mit.edu	37	3	142141705	142141705	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:142141705T>C	uc003eus.2	-	7	837	c.770A>G	c.(769-771)TAT>TGT	p.Y257C	XRN1_uc003eut.2_Missense_Mutation_p.Y257C|XRN1_uc003euu.2_Missense_Mutation_p.Y257C|XRN1_uc003euv.1_Missense_Mutation_p.Y118C|XRN1_uc003euw.2_Missense_Mutation_p.Y257C|XRN1_uc011bnh.1_Missense_Mutation_p.Y47C	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	257					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ATAGTCAATATACTCTCTCAT	0.328			NA											13	30					0	0	0.001855	0	0
SI	6476	broad.mit.edu	37	3	164700152	164700152	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:164700152C>A	uc003fei.2	-	47	5356	c.5294G>T	c.(5293-5295)AGT>ATT	p.S1765I		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1765	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CCTCGTTTCACTTTTATTTAT	0.333			NA								HNSCC(35;0.089)			36	9					1.36239e-07	1.5775e-07	0.003271	1	0
GOLIM4	27333	broad.mit.edu	37	3	167750322	167750322	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:167750322G>A	uc003ffe.2	-	9	1506	c.1162C>T	c.(1162-1164)CAC>TAC	p.H388Y	GOLIM4_uc011bpe.1_Missense_Mutation_p.H388Y|GOLIM4_uc011bpf.1_Missense_Mutation_p.H360Y|GOLIM4_uc011bpg.1_Missense_Mutation_p.H360Y	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	388	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						GCACGCGCGTGCCCTTCCAGG	0.488			NA											6	170					0	0	0.001168	0	0
MCF2L2	23101	broad.mit.edu	37	3	183006944	183006944	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr3:183006944C>A	uc003fli.1	-	14	1830	c.1740G>T	c.(1738-1740)CGG>CGT	p.R580R	MCF2L2_uc003flj.1_Silent_p.R580R|MCF2L2_uc011bqr.1_RNA|uc003fln.1_Intron	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	580					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CTTCCTTTCCCCGGGAGTTCA	0.403			NA											4	34					0.00024832	0.0002668	0.009096	1	0
HGFAC	3083	broad.mit.edu	37	4	3447936	3447936	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:3447936G>C	uc003ghc.2	+	10	1273	c.1270G>C	c.(1270-1272)GCC>CCC	p.A424P	HGFAC_uc010icw.2_Missense_Mutation_p.A431P	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	424	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CTGGCTGGCCGCCATCTACAT	0.697			NA											6	9					0	0	0.001168	0	0
CRMP1	1400	broad.mit.edu	37	4	5857888	5857888	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:5857888C>T	uc003gip.2	-	5	561	c.460G>A	c.(460-462)GTG>ATG	p.V154M	CRMP1_uc003gin.1_Missense_Mutation_p.V66M|CRMP1_uc003giq.2_Missense_Mutation_p.V154M|CRMP1_uc003gir.2_Missense_Mutation_p.V149M|CRMP1_uc003gis.2_Missense_Mutation_p.V268M	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	154					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		TGCACCAGCACCTCCAGCTCC	0.522			NA											10	49					0	0	0.010729	0	0
DRD5	1816	broad.mit.edu	37	4	9784944	9784944	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:9784944G>T	uc003gmb.3	+	1	1687	c.1291G>T	c.(1291-1293)GAG>TAG	p.E431*		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	431	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CGACGAGGAGGAGGGTCCTTT	0.577			NA											13	42					4.3838e-07	5.0381e-07	0.001855	1	0
GBA3	57733	broad.mit.edu	37	4	22749486	22749486	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:22749486G>C	uc003gqp.3	+	3	945	c.854G>C	c.(853-855)AGG>ACG	p.R285T	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.R286T	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	285					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						CCATCATCGAGGCTTCCAGAA	0.393			NA											10	23					0	0	0.006214	0	0
STIM2	57620	broad.mit.edu	37	4	27000912	27000912	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:27000912C>G	uc003gsh.3	+	5	1045	c.829C>G	c.(829-831)CAC>GAC	p.H277D	STIM2_uc003gsg.3_Missense_Mutation_p.H277D|STIM2_uc010iex.2_Missense_Mutation_p.H277D	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	190	SAM.|Extracellular (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				TGACCGGAGTCACAGACAAAA	0.368			NA											3	19					0	0	0.009096	0	0
PCDH7	5099	broad.mit.edu	37	4	30724395	30724395	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:30724395G>A	uc003gsk.1	+	1	2359	c.1351G>A	c.(1351-1353)GAC>AAC	p.D451N	PCDH7_uc011bxw.1_Missense_Mutation_p.D404N|PCDH7_uc011bxx.1_Missense_Mutation_p.D451N	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	451	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GTCCGACCGAGACCAAGGCGA	0.652			NA											3	32					0	0	0.004672	0	0
UGDH	7358	broad.mit.edu	37	4	39515741	39515741	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:39515741C>T	uc003guk.1	-	3	542	c.226G>A	c.(226-228)GAT>AAT	p.D76N	UGDH_uc011byp.1_5'UTR|UGDH_uc003gul.1_Missense_Mutation_p.D76N	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	76					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	ATGGCATCATCAATATTGGTA	0.289			NA											13	53					0	0	0.00245	0	0
N4BP2	55728	broad.mit.edu	37	4	40104480	40104480	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:40104480A>T	uc003guy.3	+	4	1353	c.1015A>T	c.(1015-1017)AAG>TAG	p.K339*	N4BP2_uc010ifq.2_Nonsense_Mutation_p.K259*|N4BP2_uc010ifr.2_Nonsense_Mutation_p.K259*	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	339	Pro-rich.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						AACTAAGGGGAAGGATGTGAG	0.512			NA											34	36					0	0	0.003271	0	0
REST	5978	broad.mit.edu	37	4	57796484	57796484	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:57796484A>T	uc003hch.2	+	4	1807	c.1460A>T	c.(1459-1461)CAG>CTG	p.Q487L	REST_uc003hci.2_Missense_Mutation_p.Q487L|REST_uc010ihf.2_Missense_Mutation_p.Q161L	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	487	Lys-rich.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					TCAGTGATCCAGGTGACTACC	0.378			NA											7	28					0	0	0.001984	0	0
PRDM8	56978	broad.mit.edu	37	4	81123069	81123069	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:81123069G>T	uc010ijo.2	+	8	1292	c.453G>T	c.(451-453)GGG>GGT	p.G151G	PRDM8_uc003hmb.3_Silent_p.G151G|PRDM8_uc003hmc.3_Silent_p.G151G	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACTAAGCAGGGTCGTCCCCTT	0.438			NA									OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	54					1.64293e-13	2.06822e-13	0.00333	1	0
NPNT	255743	broad.mit.edu	37	4	106858224	106858224	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:106858224C>A	uc003hya.2	+	4	529	c.324C>A	c.(322-324)TAC>TAA	p.Y108*	NPNT_uc011cfc.1_Nonsense_Mutation_p.Y125*|NPNT_uc011cfd.1_Nonsense_Mutation_p.Y138*|NPNT_uc011cfe.1_Nonsense_Mutation_p.Y138*|NPNT_uc010ilt.1_Nonsense_Mutation_p.Y108*|NPNT_uc011cff.1_Nonsense_Mutation_p.Y108*|NPNT_uc010ilu.1_Nonsense_Mutation_p.Y4*	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	108	EGF-like 2; calcium-binding (Potential).				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		TGAACACTTACGGCAGCTACA	0.448			NA											23	13					9.57634e-11	1.16735e-10	0.00333	1	0
TBCK	93627	broad.mit.edu	37	4	107016734	107016734	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:107016734C>G	uc010ilv.2	-	25	2841	c.2476G>C	c.(2476-2478)GGG>CGG	p.G826R	TBCK_uc003hyb.2_Missense_Mutation_p.G569R|TBCK_uc003hye.2_Missense_Mutation_p.G787R|TBCK_uc003hyc.2_Missense_Mutation_p.G763R|TBCK_uc003hyd.2_Missense_Mutation_p.G654R|TBCK_uc003hyf.2_Missense_Mutation_p.G826R	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	826	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						GTAAGCTCCCCTTCTGCAGTG	0.463			NA											23	10					0	0	0.014323	0	0
SEC24B	10427	broad.mit.edu	37	4	110415918	110415918	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:110415918C>G	uc003hzk.2	+	6	1449	c.1394C>G	c.(1393-1395)ACA>AGA	p.T465R	SEC24B_uc003hzl.2_Missense_Mutation_p.T430R|SEC24B_uc011cfp.1_Missense_Mutation_p.T496R|SEC24B_uc011cfq.1_Missense_Mutation_p.T465R|SEC24B_uc011cfr.1_Missense_Mutation_p.T430R	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	465					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		GGCTATCCAACACTTCAGCCT	0.493			NA											19	38					0	0	0.006122	0	0
ANK2	287	broad.mit.edu	37	4	114277965	114277965	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:114277965G>A	uc003ibe.3	+	38	8291	c.8191G>A	c.(8191-8193)GGC>AGC	p.G2731S	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.G33S|ANK2_uc011cgb.1_Missense_Mutation_p.G2746S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2698					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGAAGAGCCAGGCAAATCAGA	0.413			NA											19	34					0	0	0.006122	0	0
TRPC3	7222	broad.mit.edu	37	4	122835998	122835998	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:122835998C>T	uc003ieg.2	-	4	1352	c.1278G>A	c.(1276-1278)GTG>GTA	p.V426V	TRPC3_uc010inr.2_Intron|TRPC3_uc003ief.2_Silent_p.V353V|TRPC3_uc011cgl.1_Silent_p.V90V	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	341	Helical; (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						CCACGACCAGCACAACGAGAC	0.542			NA											8	14					0	0	0.006214	0	0
FHDC1	85462	broad.mit.edu	37	4	153897411	153897411	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:153897411A>T	uc003inf.2	+	11	3043	c.2968A>T	c.(2968-2970)AGG>TGG	p.R990W		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	990					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					CAAACCACTCAGGAACCTCCC	0.652			NA											21	7					0	0	0.008871	0	0
FSTL5	56884	broad.mit.edu	37	4	162463753	162463753	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:162463753G>T	uc003iqh.2	-	9	1544	c.1108C>A	c.(1108-1110)CCT>ACT	p.P370T	FSTL5_uc003iqi.2_Missense_Mutation_p.P369T|FSTL5_uc010iqv.2_Missense_Mutation_p.P369T	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	370	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCAAGCTGAGGCTTTGGTATG	0.458			NA											17	17					1.37285e-15	1.807e-15	0.004007	1	0
GLRA3	8001	broad.mit.edu	37	4	175565175	175565175	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr4:175565175T>A	uc003ity.1	-	10	1660	c.1157A>T	c.(1156-1158)TAT>TTT	p.Y386F	GLRA3_uc003itz.1_Missense_Mutation_p.Y371F	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	386	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	TCCCATTCCATAGGCTGTGAA	0.453			NA											15	39					0	0	0.00245	0	0
SLC6A19	340024	broad.mit.edu	37	5	1221831	1221831	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:1221831T>C	uc003jbw.3	+	12	1773	c.1717T>C	c.(1717-1719)TCC>CCC	p.S573P		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	573	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ATTTCCCAAATCCCAGAAGAT	0.577			NA											13	99					0	0	0.00245	0	0
IRX2	153572	broad.mit.edu	37	5	2749827	2749827	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:2749827G>A	uc003jda.2	-	2	566	c.324C>T	c.(322-324)TAC>TAT	p.Y108Y	C5orf38_uc003jdc.2_5'Flank|C5orf38_uc011cmg.1_5'Flank|C5orf38_uc011cmh.1_5'Flank|C5orf38_uc011cmi.1_5'Flank|C5orf38_uc011cmj.1_5'Flank|IRX2_uc003jdb.2_Silent_p.Y108Y	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	108						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		GCTGGTACGGGTAGGCCGCGC	0.672			NA											16	72					0	0	0.004007	0	0
DNAH5	1767	broad.mit.edu	37	5	13714584	13714584	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:13714584C>A	uc003jfd.2	-	75	13097	c.13055G>T	c.(13054-13056)CGG>CTG	p.R4352L	DNAH5_uc003jfc.2_Missense_Mutation_p.R520L	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4352					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CACCGCCTCCCGGGTCTCATC	0.562			NA							Kartagener_syndrome				41	83					9.85521e-28	1.40528e-27	0.00623	1	0
TRIO	7204	broad.mit.edu	37	5	14280519	14280519	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:14280519C>G	uc003jff.2	+	3	327	c.321C>G	c.(319-321)CTC>CTG	p.L107L	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.L58L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	107	CRAL-TRIO.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCAGGAGACTCATTTCCTATC	0.448			NA											5	57					0	0	0.000602	0	0
TRIO	7204	broad.mit.edu	37	5	14291337	14291337	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:14291337G>T	uc003jff.2	+	5	1059	c.1053G>T	c.(1051-1053)AAG>AAT	p.K351N	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.K302N|TRIO_uc003jfh.1_5'Flank	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	351	Spectrin 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					ATGCTGAGAAGGTAAAGACGG	0.557			NA											15	44					3.35478e-16	4.4283e-16	0.003163	1	0
CDH18	1016	broad.mit.edu	37	5	19543986	19543986	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:19543986G>T	uc003jgc.2	-	8	1759	c.1382C>A	c.(1381-1383)TCA>TAA	p.S461*	CDH18_uc003jgd.2_Nonsense_Mutation_p.S461*|CDH18_uc011cnm.1_Nonsense_Mutation_p.S461*	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	461	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ACCAATTTCTGAAGCAGTGAC	0.373			NA											19	45					0.000175454	0.000189836	0.010504	1	0
PRDM9	56979	broad.mit.edu	37	5	23527452	23527452	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:23527452A>T	uc003jgo.2	+	11	2437	c.2255A>T	c.(2254-2256)GAG>GTG	p.E752V		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	752	C2H2-type 10.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GTCTGCAGGGAGTGTGGGCGG	0.592			NA								HNSCC(3;0.000094)			100	96					0	0	0.01441	0	0
NPR3	4883	broad.mit.edu	37	5	32774833	32774833	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:32774833G>C	uc003jhv.2	+	4	1297	c.1079G>C	c.(1078-1080)GGA>GCA	p.G360A	NPR3_uc010iuo.2_Missense_Mutation_p.G144A|NPR3_uc011cnz.1_Missense_Mutation_p.G144A|NPR3_uc003jhu.2_Missense_Mutation_p.G360A	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	360	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	TTTGTTGAAGGATTCCACGAT	0.438			NA											21	218					0	0	0.010504	0	0
SLC45A2	51151	broad.mit.edu	37	5	33944822	33944822	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:33944822C>G	uc003jid.2	-	7	1616	c.1524G>C	c.(1522-1524)GTG>GTC	p.V508V		NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	508	Helical; Name=12; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						ACGCTGTGATCACCACGACGA	0.547	Ovarian(31;380 859 8490 22203 49048)		NA											11	51					0	0	0.010729	0	0
SPEF2	79925	broad.mit.edu	37	5	35712959	35712959	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:35712959A>C	uc003jjo.2	+	20	2996	c.2885A>C	c.(2884-2886)AAG>ACG	p.K962T	SPEF2_uc003jjp.1_Missense_Mutation_p.K448T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	962					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGAAAAGGGAAGAAAGGTGAG	0.353			NA											33	27					0	0	0.004878	0	0
ITGA2	3673	broad.mit.edu	37	5	52360854	52360854	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:52360854T>A	uc003joy.2	+	14	1858	c.1715T>A	c.(1714-1716)GTG>GAG	p.V572E	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.V496E|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	572	Extracellular (Potential).|FG-GAP 6.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TTTAATGATGTGATTGTTGGT	0.428			NA											39	49					0	0	0.005524	0	0
RNF180	285671	broad.mit.edu	37	5	63509437	63509437	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:63509437G>T	uc003jti.2	+	4	394	c.284G>T	c.(283-285)GGG>GTG	p.G95V	RNF180_uc003jth.3_Missense_Mutation_p.G95V|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	95	Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		GCCCGTTTAGGGGGCTTTAAT	0.458			NA											29	169					2.61193e-14	3.38964e-14	0.009535	1	0
CWC27	10283	broad.mit.edu	37	5	64314067	64314067	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:64314067C>A	uc003jtn.1	+	14	1557	c.1338C>A	c.(1336-1338)ATC>ATA	p.I446I	CWC27_uc010iwt.1_3'UTR	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	446					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						CATTTGAAATCTATGATCCTC	0.358			NA											13	52					0.000219431	0.000236311	0.00245	1	0
RGNEF	64283	broad.mit.edu	37	5	73148476	73148476	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:73148476G>T	uc011csq.1	+	13	1760	c.1749G>T	c.(1747-1749)GAG>GAT	p.E583D	RGNEF_uc003kcx.2_Missense_Mutation_p.E583D|RGNEF_uc003kcy.1_3'UTR|RGNEF_uc010izf.2_Missense_Mutation_p.E583D|RGNEF_uc011csr.1_Missense_Mutation_p.E270D	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	583					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		GTCTTGTAGAGCAAAGAGCTT	0.373			NA											31	67					2.42023e-17	3.25043e-17	0.003271	1	0
F2RL2	2151	broad.mit.edu	37	5	75913421	75913421	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:75913421A>T	uc003kem.2	-	2	1296	c.1111T>A	c.(1111-1113)TAC>AAC	p.Y371N	IQGAP2_uc003kek.2_Intron|IQGAP2_uc010izv.2_Intron|IQGAP2_uc011csv.1_Intron|IQGAP2_uc003kel.2_Intron|F2RL2_uc011csw.1_Missense_Mutation_p.Y349N	NM_004101	NP_004092	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	371	Cytoplasmic (Potential).				platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			skin(2)|ovary(1)	3		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		TTTGTAAGGTAAGCAGTGGAG	0.368			NA											5	25					0	0	0.000602	0	0
PCSK1	5122	broad.mit.edu	37	5	95728928	95728928	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:95728928G>T	uc003kls.1	-	14	2245	c.2039C>A	c.(2038-2040)CCG>CAG	p.P680Q	PCSK1_uc010jbi.1_Missense_Mutation_p.P370Q	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	680					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGCTTTGGCGGTGAGTTTTT	0.532			NA											38	67					8.73648e-17	1.15984e-16	0.004289	1	0
PGGT1B	5229	broad.mit.edu	37	5	114588852	114588852	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:114588852C>A	uc003kqw.3	-	2	262	c.241G>T	c.(241-243)GTC>TTC	p.V81F	PGGT1B_uc003kqx.3_5'UTR|PGGT1B_uc010jch.2_Missense_Mutation_p.V81F	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	81					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	GTGGGAAGGACCTGCAGGGAA	0.299			NA											12	44					6.42651e-13	8.00283e-13	0.010729	1	0
LOC153328	153328	broad.mit.edu	37	5	135207197	135207197	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:135207197G>T	uc003laz.1	+	5	641	c.469G>T	c.(469-471)GCA>TCA	p.A157S	LOC153328_uc003lba.2_Intron			Q6ZT89	S2548_HUMAN	RecName: Full=Putative mitochondrial carrier protein FLJ44862;	157	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGAGCAGCCAGCATACCAGGG	0.612			NA											21	67					5.35356e-11	6.54324e-11	0.00278	1	0
SMAD5	4090	broad.mit.edu	37	5	135489586	135489586	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:135489586A>G	uc003lbj.1	+	4	581	c.137A>G	c.(136-138)AAG>AGG	p.K46R	SMAD5_uc003lbk.1_Missense_Mutation_p.K46R|SMAD5_uc003lbl.1_Missense_Mutation_p.K46R	NM_001001419	NP_001001419	Q99717	SMAD5_HUMAN	SMAD family member 5	46	Poly-Lys.|MH1.				BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AAAAAGAAAAAGGGTGCCATG	0.473			NA											3	48					0	0	0.004672	0	0
PCDHA5	56143	broad.mit.edu	37	5	140201577	140201577	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:140201577C>G	uc003lhl.2	+	1	217	c.217C>G	c.(217-219)CTT>GTT	p.L73V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.L73V|PCDHA5_uc003lhj.1_Missense_Mutation_p.L73V	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	73	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding	p.Q49fs*50(1)		ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCGGGGACCTTCTGGAGGT	0.642			NA											70	100					0	0	0.01441	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475866	140475866	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:140475866C>T	uc003lil.2	+	1	1630	c.1492C>T	c.(1492-1494)CCG>TCG	p.P498S	PCDHB2_uc003lim.1_Missense_Mutation_p.P159S	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	498	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCCAGGACCCGCACCTGCC	0.672			NA											32	182					0	0	0.00623	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552496	140552496	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:140552496G>T	uc003lit.2	+	1	254	c.80G>T	c.(79-81)GGC>GTC	p.G27V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	27	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTTGGGCTGGCGCCGAACCG	0.502			NA											40	60					4.32679e-17	5.76074e-17	0.006999	1	0
PCDHB16	57717	broad.mit.edu	37	5	140563434	140563434	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:140563434G>C	uc003liv.2	+	1	2455	c.1300G>C	c.(1300-1302)GAG>CAG	p.E434Q	PCDHB16_uc010jfw.1_Missense_Mutation_p.E106Q	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	434	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGAAAACGGAGCACAACAT	0.502			NA											28	133					0	0	0.005443	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719169	140719169	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:140719169G>C	uc003ljk.1	+	1	816	c.631G>C	c.(631-633)GTT>CTT	p.V211L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.V211L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	211	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCACCACCTCGTTCTCGTGGC	0.587			NA											35	50					0	0	0.012213	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140778972	140778972	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:140778972G>T	uc003lkf.1	+	1	1278	c.1278G>T	c.(1276-1278)CCG>CCT	p.P426P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.P426P	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	426	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGCAAGCCGCCCCTCTCCT	0.512			NA											20	52					2.32416e-17	3.1305e-17	0.014323	1	0
ARHGEF37	389337	broad.mit.edu	37	5	149008500	149008500	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:149008500C>T	uc003lra.1	+	12	1853	c.1789C>T	c.(1789-1791)CTA>TTA	p.L597L		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	597					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						CAGCCCAGCTCTAGTGCCCTC	0.592			NA											15	21					0	0	0.00245	0	0
CSF1R	1436	broad.mit.edu	37	5	149459794	149459794	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:149459794A>T	uc003lrl.2	-	3	608	c.413T>A	c.(412-414)GTC>GAC	p.V138D	CSF1R_uc011dcd.1_5'UTR|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.V138D|CSF1R_uc011dce.1_Missense_Mutation_p.V138D|CSF1R_uc011dcf.1_Missense_Mutation_p.V138D	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	138	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CACCAGCGAGACGCCTGCTTC	0.642			NA											11	42					0	0	0.013537	0	0
GPX3	2878	broad.mit.edu	37	5	150405018	150405018	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:150405018G>A	uc011dcm.1	+	2	422	c.205G>A	c.(205-207)GTG>ATG	p.V69M	GPX3_uc003ltc.2_RNA|GPX3_uc003ltd.2_RNA	NM_002084	NP_002075	P22352	GPX3_HUMAN	glutathione peroxidase 3 precursor	69					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CTTTGTCAACGTGGCCAGCTA	0.522			NA											4	71					0	0	0.009096	0	0
LARP1	23367	broad.mit.edu	37	5	154188019	154188019	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:154188019A>T	uc003lvp.2	+	16	3128	c.2699A>T	c.(2698-2700)GAG>GTG	p.E900V	LARP1_uc003lvo.2_Missense_Mutation_p.E823V	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	900							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTCCCATCAGAGCGGAAACGC	0.493			NA											23	34					0	0	0.014323	0	0
CCNJL	79616	broad.mit.edu	37	5	159680645	159680645	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:159680645C>T	uc003lyb.1	-	7	1300	c.1048G>A	c.(1048-1050)GTG>ATG	p.V350M	CCNJL_uc011dee.1_Missense_Mutation_p.V302M|CCNJL_uc003lyc.1_RNA	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	350						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGTCCTGCACGGGGGTCTGG	0.677			NA											28	33					0	0	0.00632	0	0
GABRA6	2559	broad.mit.edu	37	5	161128640	161128640	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:161128640C>G	uc003lyu.2	+	9	1561	c.1223C>G	c.(1222-1224)TCG>TGG	p.S408W	GABRA6_uc003lyv.2_Missense_Mutation_p.S179W	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	408	Cytoplasmic (Probable).			S -> P (in Ref. 1; AAB36480).	gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCACCACTCTCGCCAGCCTTT	0.468			NA								TCGA Ovarian(5;0.080)			33	46					0	0	0.009535	0	0
EIF4E1B	253314	broad.mit.edu	37	5	176070182	176070182	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:176070182C>A	uc010jkf.1	+	4	699	c.115C>A	c.(115-117)CCC>ACC	p.P39T		NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	39					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCAAACTCTCCCAGGACTTT	0.448			NA											14	37					0.000219431	0.000236311	0.00245	1	0
EIF4E1B	253314	broad.mit.edu	37	5	176072502	176072502	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:176072502G>T	uc010jkf.1	+	8	1183	c.599G>T	c.(598-600)GGC>GTC	p.G200V	TSPAN17_uc003mes.3_5'Flank|TSPAN17_uc003met.2_5'Flank|TSPAN17_uc003meu.2_5'Flank|TSPAN17_uc003mev.2_5'Flank|TSPAN17_uc003mew.2_5'Flank	NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	200					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AACCAGGCGGGCGTGCTGCAC	0.627			NA											12	16					2.27111e-07	2.61659e-07	0.013537	1	0
UNC5A	90249	broad.mit.edu	37	5	176295796	176295796	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:176295796C>A	uc003mey.2	+	5	744	c.552C>A	c.(550-552)CTC>CTA	p.L184L	UNC5A_uc003mex.1_Silent_p.L184L|UNC5A_uc010jkg.1_Silent_p.L144L	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	184	Ig-like C2-type.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGAGTGGCTCCGGAACGAGG	0.682			NA											11	36					9.31168e-06	1.03913e-05	0.001855	1	0
AGXT2L2	85007	broad.mit.edu	37	5	177642304	177642304	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:177642304A>G	uc003miz.2	-	9	1307	c.1055T>C	c.(1054-1056)ATC>ACC	p.I352T	AGXT2L2_uc003miy.2_Missense_Mutation_p.I77T|AGXT2L2_uc003mjc.2_Missense_Mutation_p.I311T|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_Missense_Mutation_p.I77T|AGXT2L2_uc003mjd.1_Missense_Mutation_p.I210T	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	352						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	GGGATGTTTGATTTTTTGCTG	0.532			NA											7	31					0	0	0.001984	0	0
NEDD9	4739	broad.mit.edu	37	6	11190595	11190595	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:11190595T>A	uc003mzv.2	-	5	1674	c.1507A>T	c.(1507-1509)AGC>TGC	p.S503C	NEDD9_uc010joz.2_Missense_Mutation_p.S503C|NEDD9_uc003mzw.3_Missense_Mutation_p.S357C	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	503					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			AAGTCATGGCTGGTTTGACTC	0.517			NA											16	59					0	0	0.003163	0	0
NUP153	9972	broad.mit.edu	37	6	17688669	17688669	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:17688669C>T	uc003ncd.1	-	2	492	c.292G>A	c.(292-294)GAT>AAT	p.D98N	NUP153_uc011dje.1_Missense_Mutation_p.D98N|NUP153_uc010jpl.1_Missense_Mutation_p.D98N	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	98					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			ATTCTCCCATCAGTAATATTA	0.413			NA											25	41					0	0	0.003954	0	0
FAM65B	9750	broad.mit.edu	37	6	24850828	24850828	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:24850828G>C	uc003neo.1	-	10	971	c.795C>G	c.(793-795)ATC>ATG	p.I265M	FAM65B_uc011djs.1_Missense_Mutation_p.I294M|FAM65B_uc011dju.1_Missense_Mutation_p.I299M|FAM65B_uc003nep.2_Missense_Mutation_p.I265M|FAM65B_uc011djt.1_Missense_Mutation_p.I265M	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	265					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						ACTGTACCTTGATGGAGATGA	0.512			NA											15	40					0	0	0.00245	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26123920	26123920	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:26123920A>C	uc003ngk.3	-	1	235	c.213T>G	c.(211-213)TTT>TTG	p.F71L	HIST1H2BC_uc003ngl.2_Missense_Mutation_p.F71L|HIST1H2AC_uc003ngm.2_5'Flank|HIST1H2AC_uc003ngn.2_5'Flank|HIST1H2AC_uc003ngo.2_5'Flank|HIST1H2AC_uc003ngp.2_5'Flank	NM_003526	NP_003517	P62807	H2B1C_HUMAN	histone cluster 1, H2bc	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1						CGATGCGCTCAAATATGTCGT	0.572			NA											70	100					0	0	0.01441	0	0
HIST1H3E	8353	broad.mit.edu	37	6	26225469	26225469	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:26225469C>A	uc003nhb.2	+	2	447	c.87C>A	c.(85-87)AGC>AGA	p.S29R	HIST1H3E_uc003nhc.3_Missense_Mutation_p.S29R	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	29					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				CTCGCAAGAGCGCTCCGGCCA	0.607			NA											17	71					3.45872e-05	3.83196e-05	0.004007	1	0
OR2J2	26707	broad.mit.edu	37	6	29142013	29142013	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:29142013A>G	uc011dlm.1	+	1	703	c.601A>G	c.(601-603)ATG>GTG	p.M201V		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTGACCCTCATGGTCATGAG	0.483			NA											13	119					0	0	0.010504	0	0
ZFP57	346171	broad.mit.edu	37	6	29640726	29640726	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:29640726G>A	uc011dlw.1	-	4	1313	c.1162C>T	c.(1162-1164)CAT>TAT	p.H388Y	ZFP57_uc003nnl.3_Missense_Mutation_p.H368Y	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	304	C2H2-type 5.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						AAAGAACAATGGGGGCAACAG	0.517			NA											51	265					0	0	0.01441	0	0
PHF1	5252	broad.mit.edu	37	6	33383646	33383646	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:33383646C>T	uc003oeh.2	+	15	1711	c.1475C>T	c.(1474-1476)TCG>TTG	p.S492L	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Nonsense_Mutation_p.R457*|PHF1_uc010jux.2_Missense_Mutation_p.S292L	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	492					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				GCCCCCCACTCGATGACTGCC	0.537			NA											66	87					0	0	0.01441	0	0
ABCC10	89845	broad.mit.edu	37	6	43400666	43400666	+	Silent	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:43400666G>C	uc003ouy.1	+	3	1163	c.948G>C	c.(946-948)GGG>GGC	p.G316G	ABCC10_uc003ouz.1_Silent_p.G273G|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	316	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TGGAAGAGGGGCAGGAGCCAC	0.592			NA											21	43					0	0	0.008871	0	0
GCLC	2729	broad.mit.edu	37	6	53387311	53387311	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:53387311C>A	uc003pbw.1	-	2	553	c.165G>T	c.(163-165)TTG>TTT	p.L55F	GCLC_uc003pbx.2_Missense_Mutation_p.L55F	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	55					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CAAAAGATACCAACATGTATT	0.403			NA											3	35					0.004672	0.0049056	0.004672	1	0
FAM83B	222584	broad.mit.edu	37	6	54805944	54805944	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:54805944C>G	uc003pck.2	+	5	2291	c.2175C>G	c.(2173-2175)ACC>ACG	p.T725T		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	725										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					AGGAAGTTACCAAGAGAAACT	0.393			NA											22	42					0	0	0.00278	0	0
BAI3	577	broad.mit.edu	37	6	70071320	70071320	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:70071320G>C	uc003pev.3	+	29	4603	c.4155G>C	c.(4153-4155)AAG>AAC	p.K1385N	BAI3_uc010kak.2_Missense_Mutation_p.K1385N|BAI3_uc011dxx.1_Missense_Mutation_p.K591N	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1385	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CAGCTGTGAAGAATTTCATGG	0.438			NA											10	74					0	0	0.006214	0	0
BCKDHB	594	broad.mit.edu	37	6	80816606	80816606	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:80816606G>C	uc003pjd.2	+	1	263	c.196G>C	c.(196-198)GGG>CGG	p.G66R	BCKDHB_uc003pje.2_Missense_Mutation_p.G66R	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	66					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		CCGGGAGTACGGTGAGCCCTG	0.701			NA											3	5					0	0	0.004672	0	0
HACE1	57531	broad.mit.edu	37	6	105233031	105233031	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:105233031G>A	uc003pqu.1	-	12	1515	c.1238C>T	c.(1237-1239)CCT>CTT	p.P413L	HACE1_uc010kcy.1_5'UTR|HACE1_uc010kcz.1_Missense_Mutation_p.P413L|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Missense_Mutation_p.P66L	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	413					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		ATAGCTCCCAGGTCCTGGAGG	0.433			NA											15	31					0	0	0.003163	0	0
ATG5	9474	broad.mit.edu	37	6	106727555	106727555	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:106727555G>A	uc003prf.2	-	5	812	c.459C>T	c.(457-459)CTC>CTT	p.L153L	ATG5_uc010kdb.2_Silent_p.L153L|ATG5_uc003prg.2_Silent_p.L75L|ATG5_uc010kdc.2_Intron	NM_004849	NP_004840	Q9H1Y0	ATG5_HUMAN	APG5 autophagy 5-like	153					apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			large_intestine(1)	1	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)		ATCCCATCCAGAGTTGCTTGT	0.303			NA											7	29					0	0	0.00308	0	0
TAAR6	319100	broad.mit.edu	37	6	132891745	132891745	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:132891745G>T	uc011eck.1	+	1	285	c.285G>T	c.(283-285)GAG>GAT	p.E95D		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	95	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		GGACGGTGGAGAGCTGCTGGT	0.502			NA											32	93					1.74807e-11	2.14789e-11	0.010818	1	0
SYNE1	23345	broad.mit.edu	37	6	152738009	152738009	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:152738009C>A	uc010kiw.2	-	41	6165	c.5563G>T	c.(5563-5565)GAG>TAG	p.E1855*	SYNE1_uc003qot.3_Nonsense_Mutation_p.E1862*|SYNE1_uc003qou.3_Nonsense_Mutation_p.E1855*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.E1838*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1855	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGCTGGCCTCCTCAAACAGC	0.602			NA								HNSCC(10;0.0054)			9	60					1.76689e-08	2.06659e-08	0.006214	1	0
IGF2R	3482	broad.mit.edu	37	6	160430048	160430048	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:160430048C>G	uc003qta.2	+	3	444	c.296C>G	c.(295-297)TCT>TGT	p.S99C		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	99	1.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATAGGTGACTCTGTTTTGAGA	0.403			NA											20	53					0	0	0.010504	0	0
PLG	5340	broad.mit.edu	37	6	161139345	161139345	+	Silent	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:161139345T>A	uc003qtm.3	+	8	870	c.807T>A	c.(805-807)TCT>TCA	p.S269S		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	269					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CACCATCTTCTGGTCCCACCT	0.378			NA											27	52					0	0	0.005443	0	0
AGPAT4	56895	broad.mit.edu	37	6	161567608	161567608	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr6:161567608G>C	uc003qtr.1	-	7	1018	c.791C>G	c.(790-792)CCT>CGT	p.P264R	AGPAT4_uc003qts.1_Missense_Mutation_p.P124R|AGPAT4_uc011egb.1_Missense_Mutation_p.P102R	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	264					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		ATCGTCTTCAGGGATGTCTTC	0.587			NA											9	57					0	0	0.006214	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6094328	6094328	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:6094328A>T	uc003spp.2	-	2	272	c.126T>A	c.(124-126)GAT>GAA	p.D42E	EIF2AK1_uc003spq.2_Missense_Mutation_p.D42E|EIF2AK1_uc011jwm.1_5'UTR	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	42					negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CTGCTGGAACATCAGATTCTA	0.338			NA											5	61					0	0	0.001168	0	0
THSD7A	221981	broad.mit.edu	37	7	11676584	11676584	+	Silent	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:11676584T>C	uc003ssf.3	-	2	447	c.195A>G	c.(193-195)CCA>CCG	p.P65P		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	65	TSP type-1 1.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ATCGGCCCCATGGACCTACAA	0.443			NA								HNSCC(18;0.044)			16	59					0	0	0.003163	0	0
HOXA1	3198	broad.mit.edu	37	7	27134078	27134078	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:27134078G>C	uc003sye.2	-	2	1083	c.989C>G	c.(988-990)ACT>AGT	p.T330S	HOXA1_uc003syd.2_3'UTR|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	330						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						GGTAGTCAGAGTGTCTGAGGT	0.597			NA											7	60					0	0	0.00308	0	0
AEBP1	165	broad.mit.edu	37	7	44144413	44144413	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:44144413G>A	uc003tkb.2	+	1	454	c.149G>A	c.(148-150)CGG>CAG	p.R50Q		NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	50	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCTGAGCCCCGGGAGGACGAC	0.726			NA											3	14					0	0	0.004672	0	0
PKD1L1	168507	broad.mit.edu	37	7	47842862	47842862	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:47842862C>A	uc003tny.1	-	53	7908	c.7908G>T	c.(7906-7908)ATG>ATT	p.M2636I	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2636	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AGCAGGATGCCATTGTGTTTT	0.478			NA											15	43					0.00316338	0.00333672	0.003163	1	0
EGFR	1956	broad.mit.edu	37	7	55224477	55224477	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:55224477C>A	uc003tqk.2	+	10	1405	c.1159C>A	c.(1159-1161)CTG>ATG	p.L387M	EGFR_uc003tqh.2_Missense_Mutation_p.L387M|EGFR_uc003tqi.2_Missense_Mutation_p.L387M|EGFR_uc003tqj.2_Missense_Mutation_p.L387M|EGFR_uc010kzg.1_Missense_Mutation_p.L342M|EGFR_uc011kco.1_Missense_Mutation_p.L334M|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	387	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TACTCCTCCTCTGGATCCACA	0.363			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			37	30					1.04594e-18	1.42966e-18	0.00623	1	0
EGFR	1956	broad.mit.edu	37	7	55259524	55259524	+	Missense_Mutation	SNP	T	T	A	rs121913444		TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:55259524T>A	uc003tqk.2	+	21	2828	c.2582T>A	c.(2581-2583)CTG>CAG	p.L861Q	EGFR_uc010kzg.1_Missense_Mutation_p.L816Q|EGFR_uc011kco.1_Missense_Mutation_p.L808Q|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	861	Cytoplasmic (Potential).|Protein kinase.		L -> Q (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L861Q(96)|p.L861R(10)|p.A859_L883>V(2)|p.L861F(1)|p.L861V(1)|p.L861P(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTGGCCAAACTGCTGGGTGCG	0.557			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			96	60					0	0	0.01441	0	0
ZNF716	441234	broad.mit.edu	37	7	57528740	57528740	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:57528740C>T	uc011kdi.1	+	4	685	c.573C>T	c.(571-573)GGC>GGT	p.G191G		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AAAACGATGGCAAATCATTTT	0.338			NA											10	10					0	0	0.006214	0	0
MUC17	140453	broad.mit.edu	37	7	100684210	100684210	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:100684210C>A	uc003uxp.1	+	3	9566	c.9513C>A	c.(9511-9513)GTC>GTA	p.V3171V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3171	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|51.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATATGCCTGTCAGCACCATGC	0.473			NA											8	402					0.000157383	0.000170683	0.00308	1	0
MUC17	140453	broad.mit.edu	37	7	100686420	100686420	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:100686420C>G	uc003uxp.1	+	3	11776	c.11723C>G	c.(11722-11724)CCT>CGT	p.P3908R	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3908	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTTTTACCCCTTCTACTGAC	0.478			NA											16	116					0	0	0.006122	0	0
MUC17	140453	broad.mit.edu	37	7	100686595	100686595	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:100686595A>G	uc003uxp.1	+	3	11951	c.11898A>G	c.(11896-11898)ATA>ATG	p.I3966M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3966	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCCCTGTGATAACTTCCACTG	0.453			NA											5	128					0	0	0.001168	0	0
TMEM168	64418	broad.mit.edu	37	7	112424094	112424094	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:112424094T>C	uc003vgn.2	-	2	1179	c.787A>G	c.(787-789)AGA>GGA	p.R263G	TMEM168_uc010lju.2_Missense_Mutation_p.R263G|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	263						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						GAAAGTCTTCTGCAAATTCTT	0.353			NA											29	128					0	0	0.00632	0	0
FLNC	2318	broad.mit.edu	37	7	128494176	128494176	+	Silent	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:128494176C>G	uc003vnz.3	+	40	6842	c.6633C>G	c.(6631-6633)ACC>ACG	p.T2211T	FLNC_uc003voa.3_Silent_p.T2178T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2211	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGGAGTCCACCCAGGTCGGCG	0.692			NA											14	16					0	0	0.00245	0	0
FLNC	2318	broad.mit.edu	37	7	128494178	128494178	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:128494178A>T	uc003vnz.3	+	40	6844	c.6635A>T	c.(6634-6636)CAG>CTG	p.Q2212L	FLNC_uc003voa.3_Missense_Mutation_p.Q2179L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2212	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GAGTCCACCCAGGTCGGCGGG	0.692			NA											13	16					0	0	0.001855	0	0
NUP205	23165	broad.mit.edu	37	7	135258468	135258468	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:135258468C>G	uc003vsw.2	+	3	269	c.238C>G	c.(238-240)CAA>GAA	p.Q80E	NUP205_uc011kqa.1_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	80					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CATTCAGGGTCAACAGGGAAC	0.393			NA											9	26					0	0	0.004482	0	0
CASP2	835	broad.mit.edu	37	7	143000948	143000948	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:143000948G>A	uc003wco.2	+	9	1186	c.1039G>A	c.(1039-1041)GAT>AAT	p.D347N	CASP2_uc003wcp.2_3'UTR|CASP2_uc011kta.1_Missense_Mutation_p.D231N|CASP2_uc003wcq.2_RNA|CASP2_uc011ktb.1_Missense_Mutation_p.D97N	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	347					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					CGAGGAGAGTGATGCCGGTAA	0.502			NA											6	14					0	0	0.001168	0	0
PDIA4	9601	broad.mit.edu	37	7	148703045	148703045	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:148703045C>A	uc003wff.2	-	8	1514	c.1232G>T	c.(1231-1233)AGG>ATG	p.R411M		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	411					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CAGGGGGCGCCTGGTGTAGCG	0.632			NA									OREG0018420	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	38					3.83957e-06	4.33712e-06	0.00278	1	0
ZNF212	7988	broad.mit.edu	37	7	148951158	148951158	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:148951158C>G	uc003wfp.2	+	5	1236	c.1140C>G	c.(1138-1140)TGC>TGG	p.C380W		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	380	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GCTTCAGCTGCAAGGTGAGCC	0.612			NA											9	9					0	0	0.004482	0	0
AGAP3	116988	broad.mit.edu	37	7	150784108	150784108	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:150784108G>C	uc003wjg.1	+	1	283	c.280G>C	c.(280-282)GAG>CAG	p.E94Q	AGAP3_uc003wje.1_Intron|AGAP3_uc003wjf.1_Missense_Mutation_p.E94Q|AGAP3_uc010lpy.1_Missense_Mutation_p.E94Q	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	58					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						CGAGCGCATCGAGGATTTGGC	0.662			NA											6	16					0	0	0.001168	0	0
GALNTL5	168391	broad.mit.edu	37	7	151680215	151680215	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:151680215G>A	uc003wkp.2	+	4	736	c.513G>A	c.(511-513)TTG>TTA	p.L171L	GALNTL5_uc003wkq.2_Intron|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Silent_p.L60L	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	171	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		AAATTATTTTGGTAGATGACA	0.279			NA											28	54					0	0	0.00632	0	0
PTPRN2	5799	broad.mit.edu	37	7	157475553	157475553	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:157475553G>T	uc003wno.2	-	13	1986	c.1865C>A	c.(1864-1866)TCC>TAC	p.S622Y	PTPRN2_uc003wnp.2_Missense_Mutation_p.S605Y|PTPRN2_uc003wnq.2_Missense_Mutation_p.S593Y|PTPRN2_uc003wnr.2_Missense_Mutation_p.S584Y|PTPRN2_uc011kwa.1_Missense_Mutation_p.S645Y	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	622	Helical; (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GCAGGCGAGGGAGACCAGGGT	0.597			NA											32	39					6.04164e-23	8.5359e-23	0.010818	1	0
DLGAP2	9228	broad.mit.edu	37	8	1513916	1513916	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:1513916T>C	uc003wpl.2	+	3	1155	c.1058T>C	c.(1057-1059)ATG>ACG	p.M353T	DLGAP2_uc003wpm.2_Missense_Mutation_p.M353T	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	432					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGCAGGAGAATGAGAAGTGGG	0.557			NA											4	35					0	0	0.000602	0	0
DLGAP2	9228	broad.mit.edu	37	8	1645345	1645345	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:1645345G>A	uc003wpl.2	+	11	2686	c.2589G>A	c.(2587-2589)CAG>CAA	p.Q863Q	DLGAP2_uc003wpm.2_Silent_p.Q849Q	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	942					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CGACGTCGCAGGACCTGGCCG	0.647			NA											10	47					0	0	0.006214	0	0
BLK	640	broad.mit.edu	37	8	11412886	11412886	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:11412886G>C	uc003wty.2	+	8	1246	c.665G>C	c.(664-666)CGC>CCC	p.R222P	BLK_uc003wtz.2_Missense_Mutation_p.R151P	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	222					intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CCCTGTGTGCGCCCGGCCCCG	0.617			NA											13	63					0	0	0.001855	0	0
GATA4	2626	broad.mit.edu	37	8	11606499	11606499	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:11606499C>T	uc003wuc.2	+	3	1242	c.688C>T	c.(688-690)CGA>TGA	p.R230*	GATA4_uc003wub.1_Nonsense_Mutation_p.R24*|GATA4_uc011kxc.1_Nonsense_Mutation_p.R231*	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	230	GATA-type 1.				atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		GCTCTGGAGGCGAGATGGGAC	0.567			NA											18	98					0	0	0.006122	0	0
UNC5D	137970	broad.mit.edu	37	8	35624523	35624523	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:35624523T>A	uc003xjr.1	+	15	2745	c.2417T>A	c.(2416-2418)ATC>AAC	p.I806N	UNC5D_uc003xjs.1_Missense_Mutation_p.I801N|UNC5D_uc003xju.1_Missense_Mutation_p.I382N	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	806	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TCCTGCAAAATCTGCATTCGG	0.557			NA											5	59					0	0	0.000602	0	0
FGFR1	2260	broad.mit.edu	37	8	38314957	38314957	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:38314957C>A	uc003xlp.2	-	2	950	c.8G>T	c.(7-9)AGC>ATC	p.S3I	FGFR1_uc011lbo.1_Missense_Mutation_p.S3I|FGFR1_uc011lbp.1_Missense_Mutation_p.S3I|FGFR1_uc011lbq.1_Missense_Mutation_p.S3I|FGFR1_uc010lwk.2_5'UTR|FGFR1_uc011lbs.1_5'UTR|FGFR1_uc011lbt.1_Missense_Mutation_p.S3I|FGFR1_uc011lbu.1_Missense_Mutation_p.S36I|FGFR1_uc011lbv.1_Missense_Mutation_p.S3I|FGFR1_uc011lbw.1_Missense_Mutation_p.S3I|FGFR1_uc011lbx.1_Missense_Mutation_p.S3I|FGFR1_uc003xlv.2_Missense_Mutation_p.S3I|FGFR1_uc003xlu.2_Missense_Mutation_p.S3I|FGFR1_uc003xlw.1_RNA	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	3					axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	GCACTTCCAGCTCCACATCCC	0.572	Melanoma(146;1153 1840 21453 21841 43625)		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						24	13					1.64293e-13	2.06822e-13	0.00333	1	0
PXDNL	137902	broad.mit.edu	37	8	52336147	52336147	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:52336147G>C	uc003xqu.3	-	14	1884	c.1783C>G	c.(1783-1785)CTT>GTT	p.L595V		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	595	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GTGACTGTAAGAAACATGTTG	0.453			NA											10	15					0	0	0.008291	0	0
PRDM14	63978	broad.mit.edu	37	8	70980575	70980575	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:70980575C>A	uc003xym.2	-	4	1004	c.802G>T	c.(802-804)GTG>TTG	p.V268L		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	268	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CTGCAGAACACACCAAAATGT	0.478	NSCLC(129;99 1813 5906 40656 46114)		NA											14	16					0.000151284	0.000165233	0.001855	1	0
PI15	51050	broad.mit.edu	37	8	75756296	75756296	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:75756296G>A	uc003yal.2	+	3	533	c.354G>A	c.(352-354)CTG>CTA	p.L118L	uc003yak.1_Intron|PI15_uc003yam.2_Silent_p.L118L	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	118						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			CTTACTTACTGAGATTTTTGG	0.423			NA											7	40					0	0	0.00308	0	0
ZFHX4	79776	broad.mit.edu	37	8	77690655	77690655	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:77690655A>T	uc003yav.2	+	4	3614	c.3227A>T	c.(3226-3228)GAT>GTT	p.D1076V	ZFHX4_uc003yau.1_Missense_Mutation_p.D1102V|ZFHX4_uc003yaw.1_Missense_Mutation_p.D1076V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1076						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTTGTTAAAGATTGCCCACCA	0.463			NA								HNSCC(33;0.089)			3	49					0	0	0.009096	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814840	106814840	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:106814840A>T	uc003ymd.2	+	8	2553	c.2530A>T	c.(2530-2532)ACC>TCC	p.T844S	ZFPM2_uc011lhs.1_Missense_Mutation_p.T575S	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	844					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGAGCGGACGACCACGTCTCC	0.458			NA											5	15					0	0	0.000602	0	0
GPR20	2843	broad.mit.edu	37	8	142367614	142367614	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:142367614G>A	uc003ywf.2	-	2	499	c.410C>T	c.(409-411)TCC>TTC	p.S137F		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	137	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			GAAGAGGATGGAGCAGTGCAT	0.682			NA											17	47					0	0	0.004007	0	0
LYPD2	137797	broad.mit.edu	37	8	143832527	143832527	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:143832527G>T	uc003ywz.2	-	2	203	c.120C>A	c.(118-120)ATC>ATA	p.I40I		NM_205545	NP_991108	Q6UXB3	LYPD2_HUMAN	LY6/PLAUR domain containing 2 precursor	40	UPAR/Ly6.					anchored to membrane|plasma membrane					0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGCAGGTGGCGATGGTGACAC	0.657			NA											23	150					3.5997e-14	4.65843e-14	0.014323	1	0
RANBP6	26953	broad.mit.edu	37	9	6013819	6013819	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:6013819A>C	uc003zjr.2	-	1	1800	c.1789T>G	c.(1789-1791)TCA>GCA	p.S597A	RANBP6_uc011lmf.1_Missense_Mutation_p.S245A|RANBP6_uc003zjs.2_Missense_Mutation_p.S185A	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	597					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TTTAAGTCTGATTGTGTCTTC	0.368			NA											8	59					0	0	0.004482	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627428	43627428	+	Missense_Mutation	SNP	G	G	A	rs11261835	by1000genomes	TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:43627428G>A	uc011lrb.1	-	4	1288	c.1259C>T	c.(1258-1260)CCC>CTC	p.P420L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	420						integral to membrane					0						GTGCAGAGAGGGGAGGCCCCA	0.498			NA											4	35					0	0	0.009096	0	0
MAMDC2	256691	broad.mit.edu	37	9	72783656	72783656	+	Silent	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:72783656T>C	uc004ahm.2	+	10	2060	c.1443T>C	c.(1441-1443)TGT>TGC	p.C481C	MAMDC2_uc004ahn.2_RNA|uc004aho.1_Intron	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	481	MAM 3.					endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						TCTGGGACTGTGGGCTTGTAG	0.398			NA											6	12					0	0	0.001168	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322624	79322624	+	Silent	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:79322624A>T	uc010mpk.2	-	8	4690	c.4566T>A	c.(4564-4566)CTT>CTA	p.L1522L		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1522					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CGGCTCCTGGAAGGCTATTTT	0.418			NA											16	14					0	0	0.003163	0	0
SUSD3	203328	broad.mit.edu	37	9	95846817	95846817	+	Splice_Site	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:95846817A>T	uc004atb.2	+	5	594	c.558_splice	c.e5-2	p.T186_splice	SUSD3_uc004atc.2_Splice_Site_p.T173_splice	NM_145006	NP_659443	Q96L08	SUSD3_HUMAN	sushi domain containing 3							integral to membrane				breast(2)|skin(2)|ovary(1)|lung(1)	6						CTCTCTCCACAGAGACCATGG	0.602			NA											18	27					0	0	0.008871	0	0
GABBR2	9568	broad.mit.edu	37	9	101148033	101148033	+	Silent	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:101148033T>C	uc004ays.2	-	11	1707	c.1551A>G	c.(1549-1551)CCA>CCG	p.P517P		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	517	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	TGTTCATGTATGGACTCGACA	0.383			NA											8	19					0	0	0.00308	0	0
OR13C8	138802	broad.mit.edu	37	9	107332000	107332000	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:107332000C>A	uc011lvo.1	+	1	552	c.552C>A	c.(550-552)ATC>ATA	p.I184I		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCTGGCTATCTTGAAACTGG	0.383			NA											16	45					8.60227e-14	1.09786e-13	0.004007	1	0
PTGS1	5742	broad.mit.edu	37	9	125154703	125154703	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:125154703G>T	uc004bmg.1	+	11	1815	c.1680G>T	c.(1678-1680)ACG>ACT	p.T560T	PTGS1_uc011lys.1_Silent_p.T498T|PTGS1_uc010mwb.1_Silent_p.T414T|PTGS1_uc004bmf.1_Silent_p.T523T|PTGS1_uc004bmh.1_Silent_p.T451T|PTGS1_uc011lyt.1_Silent_p.T451T	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	560					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TTGTCAAGACGGCCACACTGA	0.567			NA											11	56					3.86212e-05	4.23824e-05	0.008291	1	0
SARDH	1757	broad.mit.edu	37	9	136582475	136582475	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:136582475C>T	uc004cep.3	-	8	1257	c.1123G>A	c.(1123-1125)GGA>AGA	p.G375R	SARDH_uc004ceo.2_Missense_Mutation_p.G375R|SARDH_uc011mdn.1_Missense_Mutation_p.G375R|SARDH_uc011mdo.1_Missense_Mutation_p.G207R	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	375					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GACTTGATTCCTGTCTTCTCC	0.587			NA											15	41					0	0	0.00499	0	0
SOHLH1	402381	broad.mit.edu	37	9	138588558	138588558	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr9:138588558G>T	uc004cgl.2	-	5	622	c.561C>A	c.(559-561)TCC>TCA	p.S187S	SOHLH1_uc010nbe.2_Silent_p.S187S	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	187					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CCCACTGCCTGGAGGACGCAA	0.652			NA											13	23					1.5842e-08	1.87667e-08	0.001855	1	0
VCX	26609	broad.mit.edu	37	X	7811644	7811644	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:7811644G>A	uc004crz.2	+	3	427	c.208G>A	c.(208-210)GCG>ACG	p.A70T		NM_013452	NP_038480	Q9H320	VCX1_HUMAN	variable charge, X chromosome	70				A -> G (in Ref. 2; AAF28174).	chromatin organization|ribosome assembly|spermatogenesis	nucleolus	chromatin binding				0		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				GGCGGAGAGCGCGCCAGCGGC	0.692			NA											3	9					0	0	0.009096	0	0
ATXN3L	92552	broad.mit.edu	37	X	13337384	13337384	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:13337384G>T	uc010ned.2	-	1	1135	c.670C>A	c.(670-672)CAA>AAA	p.Q224K		NM_001135995	NP_001129467	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	224	UIM 1.				protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			lung(2)|ovary(2)|large_intestine(1)|skin(1)	6						TCCTCATCTTGGTCTGATGTT	0.383			NA											68	228					4.98926e-31	7.20324e-31	0.01441	1	0
MAGEB6	158809	broad.mit.edu	37	X	26212723	26212723	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:26212723G>A	uc004dbr.2	+	2	909	c.760G>A	c.(760-762)GAA>AAA	p.E254K	MAGEB6_uc010ngc.1_Missense_Mutation_p.E34K	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	254	MAGE.									ovary(3)	3						TGAATTGAAAGAAATGGATTC	0.527			NA											20	53					0	0	0.008871	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840147	27840147	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:27840147G>T	uc004dbw.2	+	3	951	c.724G>T	c.(724-726)GGG>TGG	p.G242W		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	242	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						CTTCATGTTTGGGGAGCCCAG	0.453			NA											11	29					3.86212e-05	4.23824e-05	0.008291	1	0
DMD	1756	broad.mit.edu	37	X	31792208	31792208	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:31792208C>G	uc004dda.1	-	51	7655	c.7411G>C	c.(7411-7413)GCT>CCT	p.A2471P	DMD_uc004dcr.1_Missense_Mutation_p.A11P|DMD_uc004dcs.1_Missense_Mutation_p.A11P|DMD_uc004dct.1_Missense_Mutation_p.A11P|DMD_uc004dcu.1_Missense_Mutation_p.A11P|DMD_uc004dcv.1_Missense_Mutation_p.A11P|DMD_uc004dcw.2_Missense_Mutation_p.A1127P|DMD_uc004dcx.2_Missense_Mutation_p.A1130P|DMD_uc004dcz.2_Missense_Mutation_p.A2348P|DMD_uc004dcy.1_Missense_Mutation_p.A2467P|DMD_uc004ddb.1_Missense_Mutation_p.A2463P|DMD_uc004ddd.1_Missense_Mutation_p.A11P	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2471					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTGCCAGAGCAGGTACCTCC	0.468			NA											10	45					0	0	0.006214	0	0
FAM47B	170062	broad.mit.edu	37	X	34962518	34962518	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:34962518C>A	uc004ddi.1	+	1	1588	c.1570C>A	c.(1570-1572)CGG>AGG	p.R524R		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	524										ovary(3)|breast(1)	4						CGAATTCTTACGGATAAAATA	0.493			NA											40	34					5.71845e-15	7.4842e-15	0.005524	1	0
FAM47C	442444	broad.mit.edu	37	X	37027388	37027388	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:37027388G>A	uc004ddl.1	+	1	919	c.905G>A	c.(904-906)GGA>GAA	p.G302E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	302										ovary(3)	3						CCTGAGACTGGAGTGCCTGAT	0.602			NA											15	81					0	0	0.003163	0	0
CXorf36	79742	broad.mit.edu	37	X	45013318	45013318	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:45013318G>T	uc004dgg.2	-	4	873	c.798C>A	c.(796-798)GAC>GAA	p.D266E		NM_176819	NP_789789	Q9H7Y0	CX036_HUMAN	hypothetical protein LOC79742 isoform 1	266						extracellular region				lung(1)	1						GGTAGGCAAGGTCGGCTGCCT	0.557			NA											9	73					7.48243e-07	8.55664e-07	0.006214	1	0
SLC9A7	84679	broad.mit.edu	37	X	46618393	46618393	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:46618393C>T	uc004dgu.1	-	1	80	c.72G>A	c.(70-72)CTG>CTA	p.L24L	SLC9A7_uc004dgv.1_Silent_p.L24L	NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	24					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						gcagcggcagcagcagcagcc	0.647	Pancreas(118;454 1696 1930 13865 39976)		NA											6	6					0	0	0.001168	0	0
TIMP1	7076	broad.mit.edu	37	X	47444660	47444660	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:47444660C>A	uc004dif.2	+	4	450	c.258C>A	c.(256-258)ACC>ACA	p.T86T	SYN1_uc004did.2_Intron|SYN1_uc004die.2_Intron|TIMP1_uc011mlr.1_Missense_Mutation_p.P10H|TIMP1_uc010nht.1_Missense_Mutation_p.P10H	NM_003254	NP_003245	P01033	TIMP1_HUMAN	tissue inhibitor of metalloproteinase 1	86	NTR.				erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding				0						TCGTCTACACCCCCGCCATGG	0.562			NA											5	18					0.00116845	0.0012467	0.001168	1	0
ZNF182	7569	broad.mit.edu	37	X	47836869	47836869	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:47836869T>C	uc004dir.2	-	7	963	c.617A>G	c.(616-618)TAT>TGT	p.Y206C	ZNF182_uc004dis.2_Missense_Mutation_p.Y187C|ZNF182_uc004dit.2_Missense_Mutation_p.Y206C|ZNF182_uc011mlu.1_Missense_Mutation_p.Y186C	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	206	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						TTTATAGCCATAGGGCTTCAT	0.358			NA											22	35					0	0	0.014323	0	0
CACNA1F	778	broad.mit.edu	37	X	49068380	49068380	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:49068380G>T	uc004dnb.2	-	35	4173	c.4111C>A	c.(4111-4113)CAG>AAG	p.Q1371K	CACNA1F_uc010nip.2_Missense_Mutation_p.Q1360K	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1371	Extracellular (Potential).|IV.				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	AGCACAGCCTGTGGAAAGGTC	0.562			NA											13	42					2.27111e-07	2.61659e-07	0.013537	1	0
IQSEC2	23096	broad.mit.edu	37	X	53267475	53267475	+	Silent	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:53267475C>T	uc004dsd.2	-	12	3330	c.3129G>A	c.(3127-3129)GGG>GGA	p.G1043G	IQSEC2_uc004dsc.2_Silent_p.G838G	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	1033	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						GCAACTTGATCCCAAACTGGT	0.483			NA											10	23					0	0	0.010729	0	0
HUWE1	10075	broad.mit.edu	37	X	53571710	53571710	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:53571710C>A	uc004dsp.2	-	72	11464	c.11062G>T	c.(11062-11064)GAG>TAG	p.E3688*	HUWE1_uc004dsn.2_Nonsense_Mutation_p.E2496*|HUWE1_uc004dsq.1_Nonsense_Mutation_p.E3*	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3688					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ACCACATTCTCAGCCATGTCA	0.488			NA											19	45					1.33834e-09	1.60184e-09	0.007413	1	0
ITIH5L	347365	broad.mit.edu	37	X	54800519	54800519	+	Nonsense_Mutation	SNP	C	C	A	rs145132163	by1000genomes	TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:54800519C>A	uc004dtj.2	-	6	928	c.898G>T	c.(898-900)GAA>TAA	p.E300*		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	300	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GTTACCTGTTCCATCTTGGTA	0.463			NA											4	15					0.00909568	0.00942198	0.009096	1	0
SPIN4	139886	broad.mit.edu	37	X	62570542	62570542	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:62570542T>A	uc004dvf.2	-	1	677	c.157A>T	c.(157-159)AAC>TAC	p.N53Y		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	53					gamete generation					ovary(1)|lung(1)	2						ACTGGCTCGTTGCCTTCCTTC	0.527			NA											8	22					0	0	0.004482	0	0
MED12	9968	broad.mit.edu	37	X	70348450	70348450	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:70348450C>A	uc004dyy.2	+	24	3556	c.3357C>A	c.(3355-3357)GTC>GTA	p.V1119V	MED12_uc011mpq.1_Silent_p.V1119V|MED12_uc004dyz.2_Silent_p.V1119V|MED12_uc004dza.2_Silent_p.V966V|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1119					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TCCTCCAGGTCAGTGACCTAT	0.532			NA									OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	37					2.5808e-16	3.41641e-16	0.006122	1	0
SYTL4	94121	broad.mit.edu	37	X	99956569	99956570	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:99956569_99956570CC>AA	uc004egd.3	-	5	566_567	c.210_211GG>TT	c.(208-213)CTGGGC>CTTTGC	p.G71C	SYTL4_uc010nnc.2_Missense_Mutation_p.G71C|SYTL4_uc004ege.3_Missense_Mutation_p.G71C|SYTL4_uc004egf.3_Missense_Mutation_p.G71C|SYTL4_uc004egg.3_Missense_Mutation_p.G71C	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	71	RabBD.|FYVE-type.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCAAACGGCCCAGGCTCTCCT	0.545			NA											28	51					0	0	0.004672	0	0
ZMAT1	84460	broad.mit.edu	37	X	101139699	101139699	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:101139699T>A	uc004eim.2	-	2	3685	c.187A>T	c.(187-189)AGA>TGA	p.R63*	ZMAT1_uc011mrl.1_Nonsense_Mutation_p.R234*|ZMAT1_uc004ein.2_Nonsense_Mutation_p.R63*|ZMAT1_uc011mrm.1_Nonsense_Mutation_p.R63*	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	63						nucleus	zinc ion binding			ovary(1)	1						TCTAGTCCTCTGGCTTTCTGC	0.408			NA											27	67					0	0	0.005443	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970387	101970387	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:101970387G>T	uc004ejk.2	+	4	1924	c.590G>T	c.(589-591)GGA>GTA	p.G197V	GPRASP2_uc004ejl.2_Missense_Mutation_p.G197V|GPRASP2_uc004ejm.2_Missense_Mutation_p.G197V|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	197						cytoplasm	protein binding			ovary(1)	1						CCCTGGTTTGGACCAGGGGAG	0.527			NA											34	141					4.3181e-19	5.95511e-19	0.013726	1	0
RAB9B	51209	broad.mit.edu	37	X	103080378	103080378	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:103080378C>T	uc004ell.1	-	3	622	c.337G>A	c.(337-339)GAC>AAC	p.D113N	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	113					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						TGCTCAGGGTCCTTCACATCC	0.483			NA											41	147					0	0	0.007835	0	0
ESX1	80712	broad.mit.edu	37	X	103499225	103499225	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:103499225C>A	uc004ely.2	-	2	174	c.116G>T	c.(115-117)AGG>ATG	p.R39M		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	39					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCTCCTCCCCTTGCCATCAG	0.592	Pancreas(200;1705 2227 25194 28471 45274)		NA											42	152					1.57019e-19	2.17847e-19	0.007835	1	0
AGTR2	186	broad.mit.edu	37	X	115304569	115304569	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:115304569A>G	uc004eqh.3	+	3	1243	c.1036A>G	c.(1036-1038)AGT>GGT	p.S346G		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	346	Cytoplasmic (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						GAAAAGAGAGAGTATGTCTTG	0.428			NA											22	56					0	0	0.012319	0	0
LONRF3	79836	broad.mit.edu	37	X	118123528	118123528	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:118123528C>T	uc004eqw.2	+	4	1248	c.1217C>T	c.(1216-1218)CCA>CTA	p.P406L	LONRF3_uc004eqx.2_Missense_Mutation_p.P365L|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Missense_Mutation_p.P150L	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	406					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						GCTACCTCTCCAAAAGCTGCT	0.498			NA											8	30					0	0	0.004482	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298677	125298677	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:125298677G>T	uc004euk.1	-	1	1258	c.1231C>A	c.(1231-1233)CTC>ATC	p.L411I		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	411										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						TCTTGGTTGAGCCAGCCTCTG	0.612			NA											31	106					1.62565e-12	2.01354e-12	0.012213	1	0
GPR119	139760	broad.mit.edu	37	X	129519241	129519241	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:129519241G>T	uc011muv.1	-	1	181	c.181C>A	c.(181-183)CTA>ATA	p.L61I		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	61	Extracellular (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						TCTGTGAGTAGGCCAGAGATG	0.567			NA											89	89					1.09326e-46	1.58832e-46	0.01441	1	0
FRMD7	90167	broad.mit.edu	37	X	131212132	131212132	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:131212132T>C	uc004ewn.2	-	12	2091	c.1913A>G	c.(1912-1914)GAT>GGT	p.D638G	FRMD7_uc011muy.1_Missense_Mutation_p.D623G	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	638					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TGTACTTTGATCCATTAGAAC	0.413			NA											22	68					0	0	0.00278	0	0
FAM127C	441518	broad.mit.edu	37	X	134156260	134156260	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:134156260A>T	uc004eyc.1	-	1	307	c.230T>A	c.(229-231)CTG>CAG	p.L77Q		NM_001078173	NP_001071641	Q17RB0	F127C_HUMAN	family with sequence similarity 127, member C	77											0	Acute lymphoblastic leukemia(192;0.000127)					CACCCACTGCAGGGCGGGCCC	0.602			NA											25	78					0	0	0.003954	0	0
PASD1	139135	broad.mit.edu	37	X	150840242	150840242	+	Silent	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:150840242C>A	uc004fev.3	+	13	1760	c.1428C>A	c.(1426-1428)GCC>GCA	p.A476A		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	476						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTTGTGTTGCCTTCAACCAGG	0.463			NA											10	45					0.00829132	0.00868614	0.008291	1	0
GABRQ	55879	broad.mit.edu	37	X	151818215	151818215	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:151818215G>T	uc004ffp.1	+	6	641	c.621G>T	c.(619-621)ACG>ACT	p.T207T		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	207	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATGGTTACACGGTTGAAGACA	0.438			NA											20	68					3.99206e-14	5.13741e-14	0.007413	1	0
OPN1LW	5956	broad.mit.edu	37	X	153420089	153420089	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:153420089G>C	uc004fjz.3	+	4	652	c.619G>C	c.(619-621)GTG>CTG	p.V207L		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	207	Extracellular.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGGCCCAGACGTGTTCAGCGG	0.622			NA											15	87					0	0	0.00278	0	0
GDI1	2664	broad.mit.edu	37	X	153670994	153670994	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:153670994A>C	uc004fli.3	+	11	1661	c.1319A>C	c.(1318-1320)GAC>GCC	p.D440A	GDI1_uc004flj.2_Missense_Mutation_p.D105A|FAM50A_uc004fll.3_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	440					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAACAGAACGACGTCTTTGGA	0.557			NA											24	136					0	0	0.014323	0	0
PLXNA3	55558	broad.mit.edu	37	X	153699969	153699969	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:153699969G>A	uc004flm.2	+	32	5681	c.5508G>A	c.(5506-5508)AAG>AAA	p.K1836K		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1836	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGTCACCAAGTACCGCCAGG	0.532			NA											23	50					0	0	0.014323	0	0
MPP1	4354	broad.mit.edu	37	X	154013434	154013434	+	Splice_Site	SNP	T	T	C			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:154013434T>C	uc004fmp.1	-	7	793	c.678_splice	c.e7-1	p.W226_splice	MPP1_uc010nvg.1_Splice_Site_p.W206_splice|MPP1_uc011mzv.1_Splice_Site_p.W196_splice|MPP1_uc004fmq.1_Splice_Site_p.W180_splice|MPP1_uc011mzw.1_Splice_Site_p.W209_splice|MPP1_uc010nvh.1_Intron	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1						regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCACTCGCCTGGTAGGAAAA	0.547			NA											17	14					0	0	0.004007	0	0
FUNDC2	65991	broad.mit.edu	37	X	154282872	154282872	+	Silent	SNP	G	G	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:154282872G>T	uc004fmw.2	+	5	645	c.495G>T	c.(493-495)GTG>GTT	p.V165V		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	165						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTTTTCAGGTGGTGTCATTTG	0.373			NA											29	96					2.47511e-08	2.88762e-08	0.008361	1	0
VAMP7	6845	broad.mit.edu	37	X	155119210	155119210	+	Silent	SNP	G	G	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:155119210G>A	uc004fnr.2	+	2	255	c.81G>A	c.(79-81)GAG>GAA	p.E27E	VAMP7_uc004fnt.2_Silent_p.E27E|VAMP7_uc011naa.1_Missense_Mutation_p.S10N|VAMP7_uc011nab.1_5'UTR|VAMP7_uc004fns.2_Silent_p.E27E|VAMP7_uc011nac.1_5'UTR	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	27	Longin.|Cytoplasmic (Potential).				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACTTCCTGGAGGTGACAGAGC	0.458			NA											12	60					0	0	0.010729	0	0
IL9R	3581	broad.mit.edu	37	X	155235830	155235830	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:155235830C>A	uc004fnv.1	+	7	1043	c.864C>A	c.(862-864)TAC>TAA	p.Y288*	IL9R_uc010nvn.2_Nonsense_Mutation_p.Y267*|IL9R_uc004fnu.1_Nonsense_Mutation_p.Y323*	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	288	Helical; (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCCGACCTACCTCCTGTTCA	0.423			NA											31	31					1.36615e-20	1.9126e-20	0.013726	1	0
PTAFR	5724	broad.mit.edu	37	1	28476723	28476723	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:28476723delG	uc001bpl.2	-	2	937	c.810delC	c.(808-810)GCCfs	p.A270fs	PTAFR_uc001bpm.3_Frame_Shift_Del_p.A270fs|PTAFR_uc009vte.2_Frame_Shift_Del_p.A270fs	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	270	Extracellular (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CATCATTAATGGCCTGGTGGA	0.547			NA											17	31	---	---	---	---	NA	NA	NA	NA	NA
LPPR4	9890	broad.mit.edu	37	1	99771495	99771495	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr1:99771495delG	uc001dse.2	+	7	1327	c.1221delG	c.(1219-1221)AAGfs	p.K407fs	LPPR4_uc010oue.1_Frame_Shift_Del_p.K349fs	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	407							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCATGGGGAAGGAGAACATGG	0.483			NA											17	48	---	---	---	---	NA	NA	NA	NA	NA
ABHD12B	145447	broad.mit.edu	37	14	51345565	51345565	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr14:51345565delG	uc001wys.2	+	3	350	c.335delG	c.(334-336)TGGfs	p.W112fs	ABHD12B_uc001wyq.2_Frame_Shift_Del_p.W5fs|ABHD12B_uc001wyr.2_Intron|ABHD12B_uc010any.2_RNA	NM_181533	NP_853511	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B isoform b	112							hydrolase activity			breast(1)	1	all_epithelial(31;0.00481)|Breast(41;0.148)					CTAGGGATCTGGTGAGTGCAC	0.517			NA											51	64	---	---	---	---	NA	NA	NA	NA	NA
ABCC11	85320	broad.mit.edu	37	16	48234288	48234288	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr16:48234288delG	uc002eff.1	-	14	2331	c.1981delC	c.(1981-1983)CTGfs	p.L661fs	ABCC11_uc002efg.1_Frame_Shift_Del_p.L661fs|ABCC11_uc002efh.1_Frame_Shift_Del_p.L661fs|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	661	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ACAGCAGACAGGGGGTCGTCC	0.612			NA							Cerumen_Type				17	40	---	---	---	---	NA	NA	NA	NA	NA
TTC31	64427	broad.mit.edu	37	2	74718451	74718451	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr2:74718451delC	uc002slt.2	+	7	656	c.633delC	c.(631-633)AGCfs	p.S211fs	TTC31_uc002sls.2_Frame_Shift_Del_p.S140fs|TTC31_uc010yrv.1_Frame_Shift_Del_p.S67fs|TTC31_uc002slu.2_Frame_Shift_Del_p.S67fs	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	211							binding				0						GAGATGAGAGCCCCCCATCCA	0.542			NA											35	49	---	---	---	---	NA	NA	NA	NA	NA
TMEM161B	153396	broad.mit.edu	37	5	87492083	87492083	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr5:87492083delA	uc003kjc.2	-	12	1534	c.1409delT	c.(1408-1410)CTCfs	p.L470fs	TMEM161B_uc011cty.1_Frame_Shift_Del_p.L459fs|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctx.1_Frame_Shift_Del_p.L261fs	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	470	Helical; (Potential).					integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		TGTAGAAAAGAGGCAAGCAGC	0.378			NA											8	18	---	---	---	---	NA	NA	NA	NA	NA
BMPER	168667	broad.mit.edu	37	7	34006128	34006129	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:34006128_34006129insA	uc011kap.1	+	4	471_472	c.357_358insA	c.(355-360)TTCAAAfs	p.F119fs		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	119_120	VWFC 2.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						ACAGCTCCTTCAAATGGCAGAG	0.45			NA											20	61	---	---	---	---	NA	NA	NA	NA	NA
POU6F2	11281	broad.mit.edu	37	7	39503780	39503780	+	Splice_Site	DEL	G	G	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:39503780delG	uc003thb.1	+	10	1614	c.1572_splice	c.e10-1	p.R524_splice		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TTCCCCCCCAGACACACCATC	0.448			NA											68	214	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55270296	55270296	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:55270296delC	uc003tqk.2	+	27	3495	c.3249delC	c.(3247-3249)GACfs	p.D1083fs	EGFR_uc010kzg.1_Frame_Shift_Del_p.D1038fs|EGFR_uc011kco.1_Frame_Shift_Del_p.D1030fs	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	1083	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ACAGCATAGACGACACCTTCC	0.567			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			8	13	---	---	---	---	NA	NA	NA	NA	NA
NRCAM	4897	broad.mit.edu	37	7	107832248	107832248	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr7:107832248delC	uc003vfb.2	-	18	2299	c.1828delG	c.(1828-1830)GACfs	p.D610fs	NRCAM_uc003vfc.2_Frame_Shift_Del_p.D604fs|NRCAM_uc011kmk.1_Frame_Shift_Del_p.D605fs|NRCAM_uc003vfd.2_Frame_Shift_Del_p.D586fs|NRCAM_uc003vfe.2_Frame_Shift_Del_p.D586fs	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	610	Ig-like 6.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						GTCCCGCTGTCATCGTCACTG	0.512			NA											14	36	---	---	---	---	NA	NA	NA	NA	NA
FABP9	646480	broad.mit.edu	37	8	82370844	82370845	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chr8:82370844_82370845insT	uc011lfo.1	-	3	340_341	c.340_341insA	c.(340-342)ATGfs	p.M114fs		NM_001080526	NP_001073995	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	114							lipid binding|transporter activity				0			Epithelial(68;0.186)			TACCACTACCATTTTTTCATCC	0.317			NA											9	9	---	---	---	---	NA	NA	NA	NA	NA
NLGN4X	57502	broad.mit.edu	37	X	5821599	5821600	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:5821599_5821600insT	uc010ndh.2	-	5	1620_1621	c.1119_1120insA	c.(1117-1122)CAAGGGfs	p.Q373fs	NLGN4X_uc004crp.2_Frame_Shift_Ins_p.Q393fs|NLGN4X_uc004crq.2_Frame_Shift_Ins_p.Q373fs|NLGN4X_uc010ndi.2_Frame_Shift_Ins_p.Q410fs|NLGN4X_uc004crr.2_Frame_Shift_Ins_p.Q373fs|NLGN4X_uc010ndj.2_Frame_Shift_Ins_p.Q373fs	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	373_374	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						AGGCCTTCCCCTTGGTTGACGC	0.579			NA											13	40	---	---	---	---	NA	NA	NA	NA	NA
STARD8	9754	broad.mit.edu	37	X	67938187	67938187	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:67938187delG	uc004dxa.2	+	5	1563	c.1191delG	c.(1189-1191)GTGfs	p.V397fs	STARD8_uc004dxb.2_Frame_Shift_Del_p.V477fs|STARD8_uc004dxc.3_Frame_Shift_Del_p.V397fs	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	397					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						CTGAACCAGTGGCACAGGAAG	0.532			NA											7	19	---	---	---	---	NA	NA	NA	NA	NA
GUCY2F	2986	broad.mit.edu	37	X	108631849	108631849	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7147-01A-11D-2036-08	TCGA-78-7147-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a030f9a1-a066-4c6e-82c3-24c893e38466	55464e8c-b3cb-4ceb-841d-bfdbd4a49a6e	g.chrX:108631849delG	uc004eod.3	-	15	3101	c.2825delC	c.(2824-2826)CCAfs	p.P942fs	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	942	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						ATTCCTCTTTGGGAGGCCTGA	0.458			NA											21	114	---	---	---	---	NA	NA	NA	NA	NA