Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PGD	5226	broad.mit.edu	37	1	10468178	10468178	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:10468178G>C	uc001arc.2	+	6	590	c.500G>C	c.(499-501)GGA>GCA	p.G167A	PGD_uc001ard.2_Missense_Mutation_p.E86Q|PGD_uc010oak.1_Missense_Mutation_p.G145A|PGD_uc010oal.1_Missense_Mutation_p.G154A	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	167					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		GTGGGAACTGGAGAACCCTGC	0.502			NA											23	113					0	0	0.00278	0	0
VPS13D	55187	broad.mit.edu	37	1	12383832	12383832	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:12383832G>C	uc001atv.2	+	35	8126	c.7985G>C	c.(7984-7986)TGT>TCT	p.C2662S	VPS13D_uc001atw.2_Missense_Mutation_p.C2662S|VPS13D_uc001atx.2_Missense_Mutation_p.C1850S|VPS13D_uc001aty.1_Missense_Mutation_p.C400S	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2662	UBA.				protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CTTTTGGCGTGTCAAGGTAAT	0.418			NA											19	47					0	0	0.010504	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268017	21268017	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:21268017G>C	uc001bec.2	-	9	1718	c.1462C>G	c.(1462-1464)CAA>GAA	p.Q488E	EIF4G3_uc010odi.1_Missense_Mutation_p.Q92E|EIF4G3_uc010odj.1_Missense_Mutation_p.Q487E|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Missense_Mutation_p.Q488E|EIF4G3_uc001bef.2_Missense_Mutation_p.Q487E|EIF4G3_uc001bee.2_Missense_Mutation_p.Q494E|EIF4G3_uc001beg.2_Missense_Mutation_p.Q487E|EIF4G3_uc010odk.1_Missense_Mutation_p.Q488E|EIF4G3_uc001beh.2_Missense_Mutation_p.Q499E	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	488					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TTTAAGTTTTGAGAATCCAAA	0.408			NA											21	112					0	0	0.008871	0	0
ZC3H12A	80149	broad.mit.edu	37	1	37947426	37947426	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:37947426G>C	uc001cbb.3	+	4	958	c.808G>C	c.(808-810)GTC>CTC	p.V270L	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	270					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GTACTCCTTCGTCAATGACAA	0.607			NA											7	6					0	0	0.001984	0	0
HIVEP3	59269	broad.mit.edu	37	1	42041248	42041248	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:42041248C>A	uc001cgz.3	-	5	6387	c.5174G>T	c.(5173-5175)GGG>GTG	p.G1725V	HIVEP3_uc001cha.3_Missense_Mutation_p.G1725V|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1725					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CGCCGGCTCCCCTCTCTGGGA	0.547			NA											35	150					4.65686e-17	5.87728e-17	0.003755	1	0
TIE1	7075	broad.mit.edu	37	1	43772829	43772829	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:43772829C>T	uc001ciu.2	+	5	736	c.657C>T	c.(655-657)CGC>CGT	p.R219R	TIE1_uc010okd.1_Silent_p.R219R|TIE1_uc010oke.1_Silent_p.R174R|TIE1_uc009vwq.2_Intron|TIE1_uc010okf.1_5'UTR|TIE1_uc010okg.1_5'UTR|TIE1_uc010okc.1_Silent_p.R219R	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	219	Extracellular (Potential).|EGF-like 1.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGGCTGGGCGCTGGGGGCCAG	0.637			NA											23	41					0	0	0.004656	0	0
KIAA0467	23334	broad.mit.edu	37	1	43913626	43913626	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:43913626G>C	uc001cjk.1	+	53	7312	c.6850G>C	c.(6850-6852)GAG>CAG	p.E2284Q	KIAA0467_uc001cjl.1_Missense_Mutation_p.E272Q	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3183						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGGAGAGGCTGAGCGGCACGT	0.572			NA											21	57					0	0	0.008871	0	0
SLC5A9	200010	broad.mit.edu	37	1	48713175	48713175	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:48713175T>C	uc001cro.2	+	14	2058	c.2006T>C	c.(2005-2007)TTG>TCG	p.L669S	SLC5A9_uc001crn.2_Missense_Mutation_p.L694S|SLC5A9_uc010omt.1_Missense_Mutation_p.L683S|SLC5A9_uc001crp.2_Missense_Mutation_p.L336S|SLC5A9_uc010omu.1_Missense_Mutation_p.L336S|SLC5A9_uc009vyt.1_RNA	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	669	Helical; (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						GCTGTCCTTTTGCTGGCCATC	0.522			NA											20	30					0	0	0.002299	0	0
MAGOH	4116	broad.mit.edu	37	1	53699287	53699287	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:53699287C>G	uc001cvf.1	-	3	273	c.185G>C	c.(184-186)AGA>ACA	p.R62T	MAGOH_uc010ont.1_Intron	NM_002370	NP_002361	P61326	MGN_HUMAN	mago-nashi homolog	62					mRNA 3'-end processing|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|exon-exon junction complex|nuclear speck	protein binding|RNA binding				0						GTCAATTATTCTCTTCAGTTC	0.418	Colon(150;521 2416 7674 18129)		NA											19	146					0	0	0.007413	0	0
LDLRAD1	388633	broad.mit.edu	37	1	54474683	54474683	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:54474683G>A	uc001cwm.1	-	6	608	c.590C>T	c.(589-591)TCC>TTC	p.S197F	LDLRAD1_uc010onz.1_3'UTR|LDLRAD1_uc010ooa.1_Missense_Mutation_p.S154F|LDLRAD1_uc009vzn.1_RNA	NM_001010978	NP_001010978	Q5T700	LRAD1_HUMAN	low density lipoprotein receptor class A domain	197	LDL-receptor class A 3; atypical.					integral to membrane	receptor activity			skin(2)|large_intestine(1)	3						ATACTCATCGGACCAGTCGGA	0.572			NA											20	106					0	0	0.010504	0	0
WDR78	79819	broad.mit.edu	37	1	67327902	67327902	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:67327902C>G	uc001dcx.2	-	7	1080	c.1024G>C	c.(1024-1026)GAG>CAG	p.E342Q	WDR78_uc001dcy.2_Missense_Mutation_p.E342Q|WDR78_uc009waw.2_Missense_Mutation_p.E88Q|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	342										ovary(2)	2						CTACTTGACTCAACCACAGAT	0.343			NA											6	30					0	0	0.00308	0	0
C1orf173	127254	broad.mit.edu	37	1	75107024	75107024	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:75107024C>T	uc001dgg.2	-	5	654	c.435G>A	c.(433-435)CCG>CCA	p.P145P		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	145										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCAGTGCTAACGGACTGGAAT	0.428			NA											23	38					0	0	0.00632	0	0
GBP4	115361	broad.mit.edu	37	1	89652196	89652196	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:89652196C>T	uc001dnb.2	-	10	1643	c.1527G>A	c.(1525-1527)ATG>ATA	p.M509I		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	509	Potential.					cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CTGCTTCCTTCATGGCCCGCT	0.483			NA											12	31					0	0	0.001368	0	0
HFM1	164045	broad.mit.edu	37	1	91850784	91850784	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:91850784T>C	uc001doa.3	-	6	862	c.762A>G	c.(760-762)ACA>ACG	p.T254T	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Silent_p.T254T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	254							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AACCATTTTCTGTTACCTCTG	0.259			NA											6	14					0	0	0.004482	0	0
HIAT1	64645	broad.mit.edu	37	1	100547675	100547675	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:100547675G>A	uc001dst.2	+	12	1383	c.1383G>A	c.(1381-1383)TGG>TGA	p.W461*		NM_033055	NP_149044	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	461	Extracellular (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity				0		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		CCAGCAGTTGGAGAAAGCACT	0.483			NA											5	37					0	0	0.000602	0	0
AMY2B	280	broad.mit.edu	37	1	104116440	104116440	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:104116440G>T	uc001duq.2	+	6	1240	c.624G>T	c.(622-624)GGG>GGT	p.G208G	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Silent_p.G208G|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	208					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GTGTTGCAGGGTTCAGACTTG	0.433			NA											44	287					1.00776e-21	1.28965e-21	0.00361	1	0
LRIG2	9860	broad.mit.edu	37	1	113638582	113638582	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:113638582A>G	uc001edf.1	+	7	1088	c.890A>G	c.(889-891)AAT>AGT	p.N297S	LRIG2_uc009wgn.1_Missense_Mutation_p.N194S	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	297	LRR 10.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		GTGAGCCAGAATGCTATTGAA	0.448			NA											5	35					0	0	0.000602	0	0
AMPD1	270	broad.mit.edu	37	1	115215835	115215835	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:115215835A>G	uc001efe.1	-	16	2228	c.2144T>C	c.(2143-2145)ATC>ACC	p.I715T	DENND2C_uc001eez.2_5'Flank|AMPD1_uc001eff.1_Missense_Mutation_p.I711T	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	715					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TGTCCTCCGGATATCATTTCC	0.413			NA											11	33					0	0	0.008291	0	0
SYCP1	6847	broad.mit.edu	37	1	115428757	115428757	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:115428757G>T	uc001efr.2	+	14	1226	c.1017G>T	c.(1015-1017)AAG>AAT	p.K339N	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.K339N|SYCP1_uc009wgw.2_Missense_Mutation_p.K339N	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	339	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCAAAAGGCTTTAGAGG	0.274			NA											5	29					3.59834e-05	3.92741e-05	0.001168	1	0
ANKRD35	148741	broad.mit.edu	37	1	145560150	145560150	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:145560150G>A	uc001eob.1	+	8	744	c.636G>A	c.(634-636)GCG>GCA	p.A212A	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Silent_p.A55A	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	212	ANK 5.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAGCTGACGCGGGGGCTGTGG	0.607	Melanoma(9;127 754 22988 51047)		NA											8	58					0	0	0.00308	0	0
GJA8	2703	broad.mit.edu	37	1	147380719	147380719	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:147380719G>T	uc001epu.1	+	2	700	c.637G>T	c.(637-639)GCC>TCC	p.A213S		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	213	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GTTGTCTGTGGCCTCTGTGTC	0.607	Melanoma(76;1255 1795 8195 52096)		NA											31	55					1.61788e-16	2.02789e-16	0.012213	1	0
POGZ	23126	broad.mit.edu	37	1	151380974	151380974	+	Silent	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:151380974T>A	uc001eyd.1	-	14	2451	c.2145A>T	c.(2143-2145)GCA>GCT	p.A715A	POGZ_uc001eye.1_Silent_p.A662A|POGZ_uc010pdb.1_Silent_p.A706A|POGZ_uc001eyf.1_Silent_p.A671A|POGZ_uc010pdc.1_Silent_p.A653A|POGZ_uc009wmv.1_Silent_p.A620A|POGZ_uc010pdd.1_Silent_p.A206A	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	715					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCAGCGGTGCTGCCTCCTGCA	0.567			NA											41	70					0	0	0.005524	0	0
IVL	3713	broad.mit.edu	37	1	152883987	152883987	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:152883987C>T	uc001fau.2	+	2	1760	c.1714C>T	c.(1714-1716)CAG>TAG	p.Q572*		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	572					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGTAGAGCACCAGCAGCAGAA	0.517			NA											19	59					0	0	0.007413	0	0
UBQLN4	56893	broad.mit.edu	37	1	156013886	156013886	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:156013886G>A	uc001fna.2	-	6	1053	c.1029C>T	c.(1027-1029)CCC>CCT	p.P343P	UBQLN4_uc010pgx.1_Silent_p.P323P	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	343						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					CACCGGACCCGGGGGCCTGGG	0.687			NA											6	27					0	0	0.001168	0	0
FCRL2	79368	broad.mit.edu	37	1	157740380	157740380	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:157740380G>T	uc001fre.2	-	3	188	c.129C>A	c.(127-129)AAC>AAA	p.N43K	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.N43K|FCRL2_uc009wsp.2_Missense_Mutation_p.N43K|FCRL2_uc010pia.1_Missense_Mutation_p.N43K	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	43	Ig-like C2-type 1.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GAATTTTCCAGTTCTGTTCTC	0.433			NA											21	33					1.15919e-05	1.28047e-05	0.008871	1	0
IFI16	3428	broad.mit.edu	37	1	158984538	158984538	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:158984538G>A	uc001ftf.1	+	3	675	c.68G>A	c.(67-69)AGA>AAA	p.R23K	IFI16_uc001ftg.2_Missense_Mutation_p.R23K|IFI16_uc010pis.1_Missense_Mutation_p.R23K	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	23	DAPIN.|Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TATCATTTTAGAATGGTTAAG	0.308			NA											6	54					0	0	0.001168	0	0
AIM2	9447	broad.mit.edu	37	1	159036039	159036039	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:159036039C>T	uc001ftj.1	-	4	722	c.477G>A	c.(475-477)CTG>CTA	p.L159L		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	159	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					TCTTTGCTTTCAGTACCATAA	0.443			NA											10	96					0	0	0.006214	0	0
AIM2	9447	broad.mit.edu	37	1	159036077	159036077	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:159036077C>G	uc001ftj.1	-	4	684	c.439G>C	c.(439-441)GAA>CAA	p.E147Q		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	147	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					TGAAACCCTTCTCTGATAGAT	0.453			NA											11	87					0	0	0.010729	0	0
APCS	325	broad.mit.edu	37	1	159558225	159558225	+	Missense_Mutation	SNP	G	G	T	rs151221908		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:159558225G>T	uc001ftv.2	+	2	495	c.399G>T	c.(397-399)TTG>TTT	p.L133F		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	133	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding	p.L133L(1)		ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					GGACACCTTTGGTGAAAAAGG	0.498			NA											12	40					7.93312e-07	8.97997e-07	0.00245	1	0
ATP1A4	480	broad.mit.edu	37	1	160136429	160136429	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:160136429G>A	uc001fve.3	+	8	1638	c.1159G>A	c.(1159-1161)GGC>AGC	p.G387S	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_5'UTR	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	387	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGACAAGACGGGCACCCTCAC	0.592			NA											51	86					0	0	0.00361	0	0
FAM78B	149297	broad.mit.edu	37	1	166135335	166135335	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:166135335C>T	uc001gdr.2	-	2	741	c.151G>A	c.(151-153)GCC>ACC	p.A51T	FAM78B_uc010plc.1_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	51										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CGGGCGGAGGCTTTGAAGTAG	0.627			NA											7	19					0	0	0.00308	0	0
FAM78B	149297	broad.mit.edu	37	1	166135338	166135338	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:166135338T>G	uc001gdr.2	-	2	738	c.148A>C	c.(148-150)AAA>CAA	p.K50Q	FAM78B_uc010plc.1_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	50										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					GCGGAGGCTTTGAAGTAGGGG	0.622			NA											6	18					0	0	0.001168	0	0
SELP	6403	broad.mit.edu	37	1	169580899	169580899	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:169580899G>T	uc001ggi.3	-	7	1043	c.978C>A	c.(976-978)CAC>CAA	p.H326Q	SELP_uc001ggh.2_Missense_Mutation_p.H161Q|SELP_uc009wvr.2_Missense_Mutation_p.H326Q	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	326	Sushi 3.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GGGCTTCCAGGTGCTGACACT	0.507			NA											28	74					9.80776e-20	1.2522e-19	0.00632	1	0
KIFAP3	22920	broad.mit.edu	37	1	169953793	169953793	+	Silent	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:169953793A>T	uc001ggv.2	-	12	1594	c.1323T>A	c.(1321-1323)ATT>ATA	p.I441I	KIFAP3_uc010plx.1_Silent_p.I143I	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	441					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTTCCAAGTCAATTCGTTCAT	0.363			NA											13	28					0	0	0.00245	0	0
METTL13	51603	broad.mit.edu	37	1	171753468	171753468	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:171753468G>T	uc001ghz.2	+	2	1089	c.742G>T	c.(742-744)GAG>TAG	p.E248*	METTL13_uc001gia.2_Nonsense_Mutation_p.E162*|METTL13_uc001gib.2_Intron|METTL13_uc010pml.1_Nonsense_Mutation_p.E247*	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	248							methyltransferase activity|protein binding			kidney(1)	1						GGCGGTGCAGGAGCGACAGCA	0.667			NA											18	45					1.02788e-11	1.24297e-11	0.00499	1	0
TNR	7143	broad.mit.edu	37	1	175304935	175304935	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:175304935C>T	uc001gkp.1	-	18	3624	c.3543G>A	c.(3541-3543)CAG>CAA	p.Q1181Q	TNR_uc009wwu.1_Silent_p.Q1181Q	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1181	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCTGCCGCCTCTGGAATACCT	0.373			NA											15	75					0	0	0.004007	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526212	176526212	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:176526212G>C	uc001gkz.2	+	2	1918	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	PAPPA2_uc001gky.1_Missense_Mutation_p.E252Q|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	252					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCGAGAAGCAGAGACCTTTAA	0.547			NA											18	61					0	0	0.006122	0	0
PAPPA2	60676	broad.mit.edu	37	1	176661345	176661345	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:176661345G>T	uc001gkz.2	+	6	3679	c.2515G>T	c.(2515-2517)GAA>TAA	p.E839*	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	839					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCAGTGGACTGAAAGCAGAAA	0.493			NA											49	149					3.86236e-30	5.10948e-30	0.00361	1	0
FAM5B	57795	broad.mit.edu	37	1	177249638	177249638	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:177249638C>A	uc001glf.2	+	8	1638	c.1326C>A	c.(1324-1326)AGC>AGA	p.S442R	FAM5B_uc001glg.2_Missense_Mutation_p.S337R	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	442						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						AGAGCCACAGCTGCACCTGCC	0.602			NA											20	50					9.7654e-05	0.000105122	0.007413	1	0
RASAL2	9462	broad.mit.edu	37	1	178420782	178420782	+	Silent	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:178420782G>C	uc001glr.2	+	8	1385	c.1260G>C	c.(1258-1260)CTG>CTC	p.L420L	RASAL2_uc001glq.2_Silent_p.L568L|RASAL2_uc009wxc.2_5'Flank	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	420	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						CTAGTGAACTGATAGACCATC	0.418			NA											23	94					0	0	0.002299	0	0
CFH	3075	broad.mit.edu	37	1	196716443	196716443	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:196716443G>A	uc001gtj.3	+	22	3936	c.3696G>A	c.(3694-3696)TAG>TAA	p.*1232*		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1232					complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CAAAAAGATAGAATCAATCAT	0.338			NA											4	24					0	0	0.009096	0	0
CACNA1S	779	broad.mit.edu	37	1	201019618	201019618	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:201019618G>T	uc001gvv.2	-	34	4367	c.4140C>A	c.(4138-4140)ATC>ATA	p.I1380I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1380	Phenylalkylamine binding (By similarity).|IV.|Helical; Name=S6 of repeat IV; (Potential).|Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AATTGTCCATGATGACAGCCA	0.557			NA											14	44					2.48551e-13	3.03907e-13	0.00499	1	0
CR1L	1379	broad.mit.edu	37	1	207868041	207868041	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:207868041T>C	uc001hga.3	+	5	928	c.807T>C	c.(805-807)CAT>CAC	p.H269H	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	269	Sushi 4.					cytoplasm|extracellular region|membrane					0						GGCCCTCCCATGTGAAGTGCC	0.498			NA											62	148					0	0	0.00361	0	0
PLXNA2	5362	broad.mit.edu	37	1	208216424	208216424	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:208216424G>A	uc001hgz.2	-	21	4757	c.3999C>T	c.(3997-3999)CCC>CCT	p.P1333P		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1333	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CCCGCAGGACGGGGTGGTCCT	0.602			NA											14	41					0	0	0.004007	0	0
EPRS	2058	broad.mit.edu	37	1	220156114	220156114	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:220156114C>G	uc001hly.1	-	23	3643	c.3373G>C	c.(3373-3375)GTA>CTA	p.V1125L		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1125	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	CTATTCTCACCTGTTTCACTA	0.413			NA											44	103					0	0	0.00361	0	0
GALNT2	2590	broad.mit.edu	37	1	230372141	230372141	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:230372141C>G	uc010pwa.1	+	5	588	c.516C>G	c.(514-516)ATC>ATG	p.I172M	GALNT2_uc010pvy.1_Missense_Mutation_p.I134M|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	172	Lumenal (Potential).|Catalytic subdomain A.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				AAGAAATCATCTTGGTGGATG	0.433			NA											30	52					0	0	0.012213	0	0
DISC1	27185	broad.mit.edu	37	1	231829759	231829759	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:231829759G>T	uc001huz.2	+	2	308	c.255G>T	c.(253-255)CAG>CAT	p.Q85H	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.Q40H|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.Q40H|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.Q74H|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.Q40H|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.Q40H|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.Q74H|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.Q74H|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.Q85H|DISC1_uc010pwp.1_Missense_Mutation_p.Q85H|DISC1_uc010pwq.1_Missense_Mutation_p.Q85H|DISC1_uc010pwr.1_Missense_Mutation_p.Q85H|DISC1_uc010pws.1_Missense_Mutation_p.Q85H|DISC1_uc010pwt.1_Missense_Mutation_p.Q85H|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.Q85H|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.Q85H|DISC1_uc010pxb.1_Missense_Mutation_p.Q85H|DISC1_uc010pxc.1_Missense_Mutation_p.Q85H|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Missense_Mutation_p.Q85H|DISC1_uc009xfr.2_Missense_Mutation_p.Q40H|DISC1_uc010pxf.1_Missense_Mutation_p.Q85H|DISC1_uc010pxg.1_Missense_Mutation_p.Q85H|DISC1_uc010pxh.1_Missense_Mutation_p.Q85H|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.Q85H|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Missense_Mutation_p.Q85H|DISC1_uc010pwm.1_Missense_Mutation_p.Q85H|DISC1_uc001hux.1_Missense_Mutation_p.Q85H|DISC1_uc001hvc.3_Missense_Mutation_p.Q85H|DISC1_uc010pwn.1_Missense_Mutation_p.Q85H	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	85	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GGGCCAGACAGTGTGGCCTTG	0.627			NA											12	21					5.50884e-06	6.13459e-06	0.001368	1	0
RYR2	6262	broad.mit.edu	37	1	237580399	237580399	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:237580399G>A	uc001hyl.1	+	11	944	c.824G>A	c.(823-825)TGG>TAG	p.W275*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	275	Cytoplasmic (By similarity).|MIR 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGTTCCCTTTGGAGACTAGAG	0.428			NA											13	43					0	0	0.00245	0	0
FMN2	56776	broad.mit.edu	37	1	240255892	240255893	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:240255892_240255893GG>TT	uc010pyd.1	+	1	708_709	c.483_484GG>TT	c.(481-486)GAGGAT>GATTAT	p.161_162ED>DY	FMN2_uc010pye.1_Missense_Mutation_p.161_162ED>DY	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	161_162					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGATCGCCGAGGATGTGGAAAC	0.644			NA											12	43					0	0	0.004672	0	0
RGS7	6000	broad.mit.edu	37	1	241262007	241262007	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:241262007G>A	uc001hyv.2	-	3	464	c.134C>T	c.(133-135)ACG>ATG	p.T45M	RGS7_uc010pyh.1_Missense_Mutation_p.T19M|RGS7_uc010pyj.1_Translation_Start_Site|RGS7_uc001hyu.2_Missense_Mutation_p.T45M|RGS7_uc009xgn.1_Missense_Mutation_p.T45M|RGS7_uc001hyw.2_Missense_Mutation_p.T45M	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	45	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GCTTTTGACCGTACGAATAGG	0.353			NA											3	26					0	0	0.004672	0	0
OR2L2	26246	broad.mit.edu	37	1	248201848	248201848	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:248201848C>A	uc001idw.2	+	1	375	c.279C>A	c.(277-279)TTC>TTA	p.F93L	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ctatctccttcactggatgtg	0.313			NA											51	115					1.19451e-25	1.55769e-25	0.00361	1	0
OR2M4	26245	broad.mit.edu	37	1	248402386	248402386	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:248402386G>A	uc010pzh.1	+	1	156	c.156G>A	c.(154-156)GAG>GAA	p.E52E		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCTACATAGAGAAACAGCTCC	0.478			NA											33	160					0	0	0.003755	0	0
NET1	10276	broad.mit.edu	37	10	5471146	5471146	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:5471146G>C	uc001iia.2	+	3	347	c.209G>C	c.(208-210)AGA>ACA	p.R70T	NET1_uc010qar.1_5'UTR	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	70	Necessary for nuclear localization (By similarity).|Nuclear localization signal (By similarity).				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						AGAAAACGCAGAGAGAAAGAT	0.328			NA											8	48					0	0	0.006214	0	0
GPR158	57512	broad.mit.edu	37	10	25465055	25465055	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:25465055C>A	uc001isj.2	+	1	766	c.706C>A	c.(706-708)CGC>AGC	p.R236S	LOC100128811_uc010qde.1_5'UTR	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	236	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CCACTTACACCGCCGCGGCCC	0.701			NA											3	6					2.56e-06	2.87411e-06	0.009096	1	0
APBB1IP	54518	broad.mit.edu	37	10	26849724	26849724	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:26849724G>T	uc001iss.2	+	13	1641	c.1320G>T	c.(1318-1320)TGG>TGT	p.W440C		NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	440					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CCTCTCGGTGGACAAACTTGG	0.498			NA											8	56					0.000442599	0.000470905	0.006214	1	0
NRP1	8829	broad.mit.edu	37	10	33481304	33481304	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:33481304G>C	uc001iwx.3	-	13	2490	c.1967C>G	c.(1966-1968)TCT>TGT	p.S656C	NRP1_uc001iwv.3_Missense_Mutation_p.S656C|NRP1_uc009xlz.2_Missense_Mutation_p.S649C|NRP1_uc001iww.3_Missense_Mutation_p.S468C|NRP1_uc001iwy.3_Missense_Mutation_p.S649C	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	656	Extracellular (Potential).|MAM.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	GGTCTTGTGAGAGCCCCAGCC	0.453	Melanoma(104;886 1489 44640 45944 51153)		NA											107	191					0	0	0.00361	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37421180	37421180	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:37421180C>A	uc001iza.1	+	4	454	c.355C>A	c.(355-357)CCA>ACA	p.P119T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	175	ANK 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TAGCCTCACACCACTTTTACT	0.289			NA											12	28					2.31682e-05	2.53879e-05	0.003163	1	0
ZNF33A	7581	broad.mit.edu	37	10	38343813	38343813	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:38343813G>A	uc001izh.2	+	5	936	c.758G>A	c.(757-759)AGA>AAA	p.R253K	ZNF33A_uc001izg.2_Missense_Mutation_p.R254K|ZNF33A_uc010qev.1_Missense_Mutation_p.R260K|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	253						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						GAATTTGGGAGAACTTTGTGT	0.378			NA											11	26					0	0	0.010729	0	0
RET	5979	broad.mit.edu	37	10	43596171	43596171	+	Splice_Site	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:43596171G>T	uc001jal.2	+	2	527	c.337_splice	c.e2+1	p.N113_splice	RET_uc001jak.1_Splice_Site_p.N113_splice	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a						homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	AGTGTCCGCAGTAAGGGAGCC	0.622	Melanoma(102;360 522 3376 9752 9881 14372 17251 18341 20876 24662 34807 43144 48149)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				3	4					0.004672	0.0048949	0.004672	1	0
CYP26C1	340665	broad.mit.edu	37	10	94828197	94828197	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:94828197G>T	uc010qns.1	+	6	1312	c.1312G>T	c.(1312-1314)GAA>TAA	p.E438*	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	438					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				CGCAGCGCGCGAAGATTCCCG	0.687			NA											21	19					1.55795e-14	1.92638e-14	0.012319	1	0
CYP2C18	1562	broad.mit.edu	37	10	96484212	96484212	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:96484212A>C	uc001kjv.3	+	7	1397	c.1071A>C	c.(1069-1071)AGA>AGC	p.R357S	CYP2C18_uc001kjw.3_Missense_Mutation_p.R298S|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	357					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		AGATCCAGAGATACATTGACC	0.498			NA											90	67					0	0	0.00361	0	0
C10orf12	26148	broad.mit.edu	37	10	98743574	98743574	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:98743574G>A	uc001kmv.2	+	1	2534	c.2427G>A	c.(2425-2427)ATG>ATA	p.M809I		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	809										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CCCAGTACATGAAAGTTCAGA	0.453			NA											9	20					0	0	0.006214	0	0
C10orf78	119392	broad.mit.edu	37	10	105883633	105883633	+	Silent	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:105883633A>G	uc001kxu.2	+	3	310	c.297A>G	c.(295-297)CAA>CAG	p.Q99Q	C10orf78_uc001kxs.2_Silent_p.Q86Q|C10orf78_uc001kxt.2_Silent_p.Q53Q|C10orf78_uc001kxv.2_Silent_p.Q161Q	NM_001002759	NP_001002759	Q86XK3	SFR1_HUMAN	hypothetical protein LOC119392 isoform a	99					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;1.31e-09)|all cancers(201;3.84e-08)|BRCA - Breast invasive adenocarcinoma(275;0.014)		TGGAATTTCAAGAAAGTTTTA	0.328			NA											23	21					0	0	0.012319	0	0
SORCS1	114815	broad.mit.edu	37	10	108459107	108459107	+	Silent	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:108459107C>G	uc001kym.2	-	9	1286	c.1278G>C	c.(1276-1278)GCG>GCC	p.A426A	SORCS1_uc001kyl.2_Silent_p.A426A|SORCS1_uc009xxs.2_Silent_p.A426A|SORCS1_uc001kyn.1_Silent_p.A426A|SORCS1_uc001kyo.2_Silent_p.A426A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	426	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATTCTTGGACCGCTGCGAACA	0.478			NA											25	15					0	0	0.008361	0	0
TACC2	10579	broad.mit.edu	37	10	123810054	123810054	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:123810054A>T	uc001lfv.2	+	3	495	c.135A>T	c.(133-135)AGA>AGT	p.R45S	TACC2_uc001lfw.2_Missense_Mutation_p.R45S|TACC2_uc009xzx.2_Missense_Mutation_p.R45S|TACC2_uc010qtv.1_Missense_Mutation_p.R45S	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	45						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTGACCACAGAGACGCGTCCA	0.582			NA											19	19					0	0	0.007413	0	0
BTBD16	118663	broad.mit.edu	37	10	124092011	124092011	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:124092011G>T	uc001lgc.1	+	13	1398	c.1147G>T	c.(1147-1149)GGG>TGG	p.G383W	BTBD16_uc001lgd.1_Missense_Mutation_p.G382W	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	383										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TGTGAGATTTGGGCTGCTCTT	0.512			NA											28	28					7.26314e-15	9.04187e-15	0.007291	1	0
ADAM12	8038	broad.mit.edu	37	10	127806654	127806655	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:127806654_127806655CG>AA	uc001ljk.2	-	6	977_978	c.564_565CG>TT	c.(562-567)CTCGCT>CTTTCT	p.A189S	ADAM12_uc010qul.1_Missense_Mutation_p.A186S|ADAM12_uc001ljm.2_Missense_Mutation_p.A189S|ADAM12_uc001ljn.2_Missense_Mutation_p.A186S|ADAM12_uc001ljl.3_Missense_Mutation_p.A186S	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	189					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TTCTTTGCAGCGAGGTTTGGTG	0.48			NA											51	73					0	0	0.004672	0	0
MKI67	4288	broad.mit.edu	37	10	129903851	129903851	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:129903851T>C	uc001lke.2	-	13	6448	c.6253A>G	c.(6253-6255)ACA>GCA	p.T2085A	MKI67_uc001lkf.2_Missense_Mutation_p.T1725A|MKI67_uc009yav.1_Missense_Mutation_p.T1660A|MKI67_uc009yaw.1_Missense_Mutation_p.T1235A	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2085	16 X 122 AA approximate repeats.|9.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGGTCTGGTGTCTGGAAGAGC	0.493			NA											6	299					0	0	0.001984	0	0
MUC5B	727897	broad.mit.edu	37	11	1265880	1265880	+	Silent	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:1265880C>G	uc009ycr.1	+	48	9810	c.9684C>G	c.(9682-9684)ACC>ACG	p.T3228T	MUC5B_uc001ltb.2_Silent_p.T2593T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2590	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCGGGGCCACCGGCTCTGTGG	0.647			NA											73	144					0	0	0.00361	0	0
ART5	116969	broad.mit.edu	37	11	3661095	3661095	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:3661095C>G	uc001lyb.1	-	2	957	c.564G>C	c.(562-564)AAG>AAC	p.K188N	ART5_uc001lyc.1_Missense_Mutation_p.K188N|ART5_uc001lyd.2_Missense_Mutation_p.K188N|ART5_uc009yea.2_Missense_Mutation_p.K188N	NM_053017	NP_443750	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5 precursor	188						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGCCACTGCCTTATCCAGGG	0.582			NA											24	44					0	0	0.004656	0	0
ART1	417	broad.mit.edu	37	11	3681076	3681076	+	Silent	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:3681076C>G	uc001lye.1	+	3	428	c.327C>G	c.(325-327)GGC>GGG	p.G109G	ART1_uc009yeb.1_Silent_p.G109G	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	109					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CACCCCTGGGCTTCCGCGATG	0.682			NA											22	15					0	0	0.002299	0	0
OR51S1	119692	broad.mit.edu	37	11	4870112	4870112	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:4870112C>T	uc010qyo.1	-	1	327	c.327G>A	c.(325-327)ATG>ATA	p.M109I		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGATAAAAACCATCTGTAGAA	0.557			NA											28	53					0	0	0.004656	0	0
UBQLN3	50613	broad.mit.edu	37	11	5530072	5530072	+	Silent	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:5530072C>A	uc001may.1	-	2	803	c.717G>T	c.(715-717)CGG>CGT	p.R239R	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	239										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACTGAGCACCCGGTCCTGGC	0.478	Ovarian(72;684 1260 12332 41642 52180)		NA											18	86					1.67942e-08	1.97008e-08	0.006122	1	0
DCHS1	8642	broad.mit.edu	37	11	6644840	6644840	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:6644840C>T	uc001mem.1	-	21	8477	c.8067G>A	c.(8065-8067)TTG>TTA	p.L2689L		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2689	Cadherin 25.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCACTGGTGCCAAAGCAAAGT	0.577			NA											3	20					0	0	0.004672	0	0
SYT9	143425	broad.mit.edu	37	11	7324274	7324274	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:7324274C>G	uc001mfe.2	+	2	387	c.150C>G	c.(148-150)ATC>ATG	p.I50M	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	50	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TTGCAGATATCTCAGTGAGCC	0.542			NA											25	71					0	0	0.004656	0	0
RIC3	79608	broad.mit.edu	37	11	8158962	8158962	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:8158962C>A	uc001mgd.2	-	4	538	c.484G>T	c.(484-486)GAA>TAA	p.E162*	RIC3_uc001mgb.2_5'UTR|RIC3_uc001mgc.2_Nonsense_Mutation_p.E162*|RIC3_uc001mge.2_Intron|RIC3_uc010rbl.1_Nonsense_Mutation_p.E112*|RIC3_uc010rbm.1_Nonsense_Mutation_p.E162*|RIC3_uc009yfm.2_Intron|RIC3_uc009yfn.2_Intron	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	162	Potential.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		ATTAATTTTTCCATGGCTGCT	0.368			NA											14	96					9.31168e-06	1.03275e-05	0.001855	1	0
PDE3B	5140	broad.mit.edu	37	11	14665637	14665637	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:14665637C>T	uc001mln.2	+	1	369	c.16C>T	c.(16-18)CGA>TGA	p.R6*	PDE3B_uc001mlm.2_Nonsense_Mutation_p.R6*|PDE3B_uc010rcr.1_Nonsense_Mutation_p.R6*|PSMA1_uc001mll.2_5'Flank	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	6					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						GAGGGACGAGCGAGACGCCAA	0.721			NA											3	9					0	0	0.004672	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725348	26725348	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:26725348A>T	uc001mra.2	-	5	985	c.672T>A	c.(670-672)CAT>CAA	p.H224Q	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Missense_Mutation_p.H224Q	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	224	Extracellular (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						ACTCAAATATATGTAGTCGAG	0.358			NA											42	76					0	0	0.007835	0	0
NAT10	55226	broad.mit.edu	37	11	34139952	34139952	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:34139952C>G	uc001mvk.2	+	8	926	c.682C>G	c.(682-684)CTT>GTT	p.L228V	NAT10_uc010ren.1_Missense_Mutation_p.L156V	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	228						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				GGATGAGAGTCTTGGTCCTTC	0.552			NA											4	23					0	0	0.009096	0	0
TTC17	55761	broad.mit.edu	37	11	43411234	43411234	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:43411234A>C	uc001mxi.2	+	3	296	c.282A>C	c.(280-282)GAA>GAC	p.E94D	TTC17_uc001mxh.2_Missense_Mutation_p.E94D|TTC17_uc010rfj.1_Missense_Mutation_p.E37D	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	94							binding			ovary(5)	5						TTCACATAGAAGAGAATGAGG	0.383			NA											14	48					0	0	0.003163	0	0
EXT2	2132	broad.mit.edu	37	11	44129289	44129289	+	Silent	SNP	C	C	T	rs149841763		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:44129289C>T	uc001mxz.2	+	2	361	c.27C>T	c.(25-27)ATC>ATT	p.I9I	EXT2_uc010rfo.1_Silent_p.I37I|EXT2_uc001mxy.2_Silent_p.I22I|EXT2_uc009ykt.2_Silent_p.I9I|EXT2_uc001mya.2_Silent_p.I42I	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	9	Cytoplasmic (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity	p.I9I(1)		lung(2)|breast(2)|skin(1)	5						AGTATAATATCCGGGGTCCTG	0.483			NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				16	76					0	0	0.004007	0	0
ALX4	60529	broad.mit.edu	37	11	44286517	44286517	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:44286517G>T	uc001myb.2	-	4	1227	c.1123C>A	c.(1123-1125)CCA>ACA	p.P375T		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	375					hair follicle development						0						TTGAGGCCTGGGCTGAGGCTG	0.657			NA											14	49					3.27435e-08	3.77651e-08	0.00245	1	0
MYBPC3	4607	broad.mit.edu	37	11	47356692	47356692	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:47356692T>A	uc001nfa.3	-	26	2861	c.2806A>T	c.(2806-2808)ACG>TCG	p.T936S		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	935	Fibronectin type-III 2.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		CGGGCCCCCGTGGGCAGGTCC	0.667			NA											17	29					0	0	0.007413	0	0
OR5J2	282775	broad.mit.edu	37	11	55944574	55944574	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:55944574A>G	uc010rjb.1	+	1	481	c.481A>G	c.(481-483)ATC>GTC	p.I161V		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					AATCCACACAATCAGCTTGAG	0.443			NA											25	30					0	0	0.00333	0	0
ZFP91	80829	broad.mit.edu	37	11	58378469	58378469	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:58378469G>C	uc001nmx.3	+	5	832	c.664G>C	c.(664-666)GAG>CAG	p.E222Q	ZFP91_uc001nmy.3_Missense_Mutation_p.E221Q|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	222	Glu-rich.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AATCAGTGAAGAGGAGATACC	0.373			NA											11	30					0	0	0.001855	0	0
SLC22A12	116085	broad.mit.edu	37	11	64367924	64367924	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:64367924C>G	uc001oam.1	+	8	2118	c.1371C>G	c.(1369-1371)AGC>AGG	p.S457R	SLC22A12_uc001oal.1_Missense_Mutation_p.S236R|SLC22A12_uc009yps.1_Missense_Mutation_p.S423R|SLC22A12_uc001oan.1_Missense_Mutation_p.S349R|SLC22A12_uc009ypt.2_Missense_Mutation_p.S275R	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	457					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						TCTACAGCAGCGAGCTCTTCC	0.677			NA											11	16					0	0	0.001368	0	0
EFEMP2	30008	broad.mit.edu	37	11	65635412	65635412	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:65635412G>C	uc001ofy.3	-	10	1284	c.1090C>G	c.(1090-1092)CAG>GAG	p.Q364E	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.Q364E	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	364					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GAGGTCGCCTGGATCTGGAAC	0.577			NA											14	83					0	0	0.001855	0	0
CTTN	2017	broad.mit.edu	37	11	70279327	70279327	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:70279327G>C	uc001opv.3	+	16	1593	c.1387G>C	c.(1387-1389)GCC>CCC	p.A463P	CTTN_uc001opu.2_Missense_Mutation_p.A426P|CTTN_uc001opw.3_Missense_Mutation_p.A426P|CTTN_uc010rqm.1_Missense_Mutation_p.A147P|CTTN_uc001opx.2_Missense_Mutation_p.A147P	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	463						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GCAGGGCCTGGCCTATGCCAC	0.682			NA											11	32					0	0	0.008291	0	0
USP35	57558	broad.mit.edu	37	11	77919914	77919914	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:77919914T>G	uc009yva.1	+	9	1743	c.1497T>G	c.(1495-1497)ATT>ATG	p.I499M	USP35_uc001oze.2_Missense_Mutation_p.I255M|USP35_uc001ozc.2_Missense_Mutation_p.I67M|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_Missense_Mutation_p.I110M|USP35_uc001ozf.2_Missense_Mutation_p.I230M	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	499					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GGCCTGCCATTTCCCCAGAGA	0.607			NA											172	131					0	0	0.00361	0	0
GAB2	9846	broad.mit.edu	37	11	77991716	77991716	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:77991716C>T	uc001ozh.2	-	2	307	c.307G>A	c.(307-309)GAG>AAG	p.E103K	GAB2_uc001ozg.2_Missense_Mutation_p.E65K	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	103	PH.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TTCATGTCCTCTTCTGTCTCA	0.483			NA											34	258					0	0	0.003755	0	0
NAALAD2	10003	broad.mit.edu	37	11	89885504	89885504	+	Silent	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:89885504C>A	uc001pdf.3	+	6	757	c.648C>A	c.(646-648)ATC>ATA	p.I216I	NAALAD2_uc009yvx.2_Silent_p.I216I|NAALAD2_uc009yvy.2_Silent_p.I216I|NAALAD2_uc001pdd.2_Silent_p.I216I|NAALAD2_uc001pde.2_Silent_p.I216I	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	216	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TAGGAATCATCTTGTACTCAG	0.438			NA											16	40					1.99824e-07	2.28548e-07	0.00499	1	0
FAT3	120114	broad.mit.edu	37	11	92087809	92087809	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:92087809C>T	uc001pdj.3	+	1	2548	c.2531C>T	c.(2530-2532)TCA>TTA	p.S844L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	844	Cadherin 8.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTGAAAGTTCAGGCATTGGT	0.398			NA								TCGA Ovarian(4;0.039)			21	43					0	0	0.010504	0	0
FAT3	120114	broad.mit.edu	37	11	92534064	92534064	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:92534064G>A	uc001pdj.3	+	9	7902	c.7885G>A	c.(7885-7887)GAT>AAT	p.D2629N		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2629	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGATCCCGATGATGGAGCAAA	0.502			NA								TCGA Ovarian(4;0.039)			5	25					0	0	0.000602	0	0
CNTN5	53942	broad.mit.edu	37	11	100179184	100179184	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:100179184G>A	uc001pga.2	+	21	3053	c.2714G>A	c.(2713-2715)AGA>AAA	p.R905K	CNTN5_uc001pfz.2_Missense_Mutation_p.R905K|CNTN5_uc001pgb.2_Missense_Mutation_p.R831K|CNTN5_uc010ruk.1_Missense_Mutation_p.R176K	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	905	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGTCTAGGAAGACCACAGGGA	0.428			NA											4	29					0	0	0.009096	0	0
DSCAML1	57453	broad.mit.edu	37	11	117392000	117392000	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:117392000T>G	uc001prh.1	-	6	1240	c.1238A>C	c.(1237-1239)GAG>GCG	p.E413A	DSCAML1_uc001pri.1_Missense_Mutation_p.E217A	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	353	Extracellular (Potential).|Ig-like C2-type 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGCACCAGCTCCGTGTTGCG	0.627			NA											41	71					0	0	0.006999	0	0
ABCG4	64137	broad.mit.edu	37	11	119029015	119029015	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:119029015G>A	uc001pvs.2	+	10	1476	c.1140G>A	c.(1138-1140)AGG>AGA	p.R380R	ABCG4_uc009zar.2_Silent_p.R380R	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	380	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TCTTCAAGAGGACCTTCCTGT	0.572			NA											119	239					0	0	0.00361	0	0
OR8D4	338662	broad.mit.edu	37	11	123777258	123777260	+	Missense_Mutation	TNP	GGG	GGG	TTT			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	GGG	GGG	-	-	GGG	GGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:123777258_123777260GGG>TTT	uc010saa.1	+	1	120_122	c.120_122GGG>TTT	c.(118-123)GTGGGA>GTTTTA	p.G41L		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TTACTGTGGTGGGAAACCTCAGC	0.414			NA											25	98					0	0	0.004672	0	0
OR10S1	219873	broad.mit.edu	37	11	123847664	123847664	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:123847664G>T	uc001pzm.1	-	1	735	c.735C>A	c.(733-735)GCC>GCA	p.A245A		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	245	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GCCGGCCCTGGGCTGTGCGGA	0.607			NA											34	68					6.05902e-23	7.84529e-23	0.003755	1	0
OR10G4	390264	broad.mit.edu	37	11	123886650	123886650	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:123886650G>T	uc010sac.1	+	1	369	c.369G>T	c.(367-369)TTG>TTT	p.L123F		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		ATCGCTACTTGGCCATCAGTT	0.562			NA											35	151					1.32136e-16	1.66001e-16	0.00874	1	0
ROBO4	54538	broad.mit.edu	37	11	124766430	124766430	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:124766430G>T	uc001qbg.2	-	3	677	c.537C>A	c.(535-537)GCC>GCA	p.A179A	ROBO4_uc010sas.1_Silent_p.A34A|ROBO4_uc001qbh.2_Silent_p.A69A|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	179	Ig-like C2-type 2.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CGGGCTGGAGGGCCAGGGGTT	0.637			NA											11	120					7.03913e-09	8.27512e-09	0.001368	1	0
ADAMTS15	170689	broad.mit.edu	37	11	130343292	130343292	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:130343292C>G	uc010scd.1	+	8	2429	c.2429C>G	c.(2428-2430)TCT>TGT	p.S810C		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	810	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GACAAGTCCTCTCATCCCAAG	0.657			NA											33	236					0	0	0.004289	0	0
CD163	9332	broad.mit.edu	37	12	7632510	7632510	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:7632510C>A	uc001qsz.3	-	16	3554	c.3426G>T	c.(3424-3426)AAG>AAT	p.K1142N	CD163_uc001qta.3_Splice_Site_p.G1115_splice|CD163_uc009zfw.2_Splice_Site_p.G1148_splice	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1142	Cytoplasmic (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GAATGGCCTCCTTTTCCATTC	0.373			NA											14	38					3.27435e-08	3.77651e-08	0.00245	1	0
FAM90A1	55138	broad.mit.edu	37	12	8374865	8374865	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:8374865G>A	uc001qui.2	-	7	1507	c.948C>T	c.(946-948)CCC>CCT	p.P316P	FAM90A1_uc001quh.2_Silent_p.P316P	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	316							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		TGGCGCTTTCGGGGATCTGGA	0.627			NA											13	61					0	0	0.001368	0	0
TM7SF3	51768	broad.mit.edu	37	12	27128438	27128438	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:27128438G>A	uc010sjl.1	-	11	1679	c.1441C>T	c.(1441-1443)CAA>TAA	p.Q481*		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	481	Helical; (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					CCATTAGTTTGAAAAGGCACA	0.418			NA											6	37					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	12	31297876	31297876	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:31297876A>G	uc010sjy.1	-	13	1754	c.1754T>C	c.(1753-1755)CTT>CCT	p.L585P						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						TTTCAGTAGAAGGACGTTCCC	0.483			NA											31	106					0	0	0.009535	0	0
ALG10B	144245	broad.mit.edu	37	12	38714725	38714725	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:38714725A>G	uc001rln.3	+	3	1271	c.1132A>G	c.(1132-1134)ATA>GTA	p.I378V	ALG10B_uc001rlo.3_Missense_Mutation_p.I348V|ALG10B_uc010skk.1_Missense_Mutation_p.I318V	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	378	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TCCAGCCTATATATTTGCTGG	0.303			NA											13	64					0	0	0.00245	0	0
WNT10B	7480	broad.mit.edu	37	12	49361889	49361889	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:49361889G>C	uc001rss.2	-	4	897	c.551C>G	c.(550-552)TCA>TGA	p.S184*	WNT10B_uc001rst.2_Intron	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	184					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						gctggggcttgagccagggcc	0.458			NA											21	29					0	0	0.00278	0	0
MLL2	8085	broad.mit.edu	37	12	49434560	49434560	+	Silent	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:49434560C>A	uc001rta.3	-	31	6993	c.6993G>T	c.(6991-6993)CTG>CTT	p.L2331L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2331	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCGAGGGGTCAGGGGGGCTT	0.637			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			16	21					6.94344e-10	8.28685e-10	0.006122	1	0
FIGNL2	401720	broad.mit.edu	37	12	52215995	52215995	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:52215995G>C	uc001rzc.2	-	1	214	c.203C>G	c.(202-204)TCT>TGT	p.S68C		NM_001013690	NP_001013712	A6NMB9	FIGL2_HUMAN	fidgetin-like 2	68							ATP binding|nucleoside-triphosphatase activity				0				BRCA - Breast invasive adenocarcinoma(357;0.135)		CAAGACCCCAGAGTACTTCTC	0.652			NA											6	14					0	0	0.001168	0	0
SLC26A10	65012	broad.mit.edu	37	12	58015561	58015561	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:58015561T>A	uc001spe.2	+	4	955	c.644T>A	c.(643-645)GTC>GAC	p.V215D	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_5'Flank	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	215						integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					CTCGTGCCGGTCAAGGAATTG	0.692			NA									OREG0021948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	17					0	0	0.006214	0	0
MGAT4C	25834	broad.mit.edu	37	12	86374139	86374139	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:86374139G>A	uc001tai.3	-	8	1615	c.365C>T	c.(364-366)TCA>TTA	p.S122L	MGAT4C_uc001tal.3_Missense_Mutation_p.S122L|MGAT4C_uc001taj.3_Missense_Mutation_p.S122L|MGAT4C_uc001tak.3_Missense_Mutation_p.S122L|MGAT4C_uc010sum.1_Missense_Mutation_p.S146L|MGAT4C_uc001tah.3_Missense_Mutation_p.S122L	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	122	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						CTCAAAAATTGACTTAATTGT	0.373			NA											14	33					0	0	0.00245	0	0
RAD9B	144715	broad.mit.edu	37	12	110944491	110944491	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:110944491C>T	uc001trf.3	+	4	519	c.381C>T	c.(379-381)TAC>TAT	p.Y127Y	RAD9B_uc001trg.3_Silent_p.Y127Y|RAD9B_uc010sya.1_Silent_p.Y127Y|RAD9B_uc001tre.3_Silent_p.Y55Y|RAD9B_uc001trd.3_5'UTR	NM_152442	NP_689655	Q6WBX8	RAD9B_HUMAN	RAD9 homolog B	124					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			pancreas(1)|skin(1)	2						AATTCTTCTACAGACATGGTA	0.299			NA											15	64					0	0	0.00245	0	0
SLC24A6	80024	broad.mit.edu	37	12	113748059	113748059	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:113748059G>A	uc001tvc.2	-	12	1447	c.1237C>T	c.(1237-1239)CAG>TAG	p.Q413*	SLC24A6_uc001tuz.2_Nonsense_Mutation_p.Q118*|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Nonsense_Mutation_p.Q151*	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	413	Extracellular (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						CTGGGGGGCTGGCTGTCAGAT	0.592			NA											7	33					0	0	0.004482	0	0
ABCB9	23457	broad.mit.edu	37	12	123419844	123419844	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:123419844C>T	uc001udm.3	-	10	2188	c.1878G>A	c.(1876-1878)ATG>ATA	p.M626I	ABCB9_uc010tai.1_Missense_Mutation_p.M233I|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.M583I|ABCB9_uc010taj.1_Missense_Mutation_p.M563I|ABCB9_uc001udp.2_Missense_Mutation_p.M626I|ABCB9_uc001udq.2_Missense_Mutation_p.M345I	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	626	ABC transporter.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CCTGGAGTTCCATGATGAAGC	0.617	Ovarian(49;786 1333 9175 38236)		NA											4	14					0	0	0.009096	0	0
DNAH10	196385	broad.mit.edu	37	12	124397651	124397651	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr12:124397651A>T	uc001uft.3	+	59	9812	c.9787A>T	c.(9787-9789)AGG>TGG	p.R3263W		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3263	Potential.|Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTAGGTGGCCAGGCTGGAGCG	0.498			NA											5	13					0	0	0.000602	0	0
TUBA3C	7278	broad.mit.edu	37	13	19748132	19748132	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:19748132G>A	uc009zzj.2	-	5	1273	c.1224C>T	c.(1222-1224)TAC>TAT	p.Y408Y		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	408					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CTTCTCCCACGTACCAGTGCA	0.602			NA											56	127					0	0	0.00361	0	0
ATP12A	479	broad.mit.edu	37	13	25262552	25262552	+	Silent	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:25262552C>G	uc001upp.2	+	4	511	c.324C>G	c.(322-324)CTC>CTG	p.L108L	ATP12A_uc010aaa.2_Silent_p.L108L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	108	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCAAGTTCCTCAAGCAGATGG	0.607	Pancreas(156;1582 1935 18898 22665 26498)		NA											58	284					0	0	0.00361	0	0
FRY	10129	broad.mit.edu	37	13	32749689	32749689	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:32749689G>A	uc001utx.2	+	20	2837	c.2341G>A	c.(2341-2343)GAC>AAC	p.D781N	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	781					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACAGGATGACGACAGGCCGAT	0.453			NA											22	38					0	0	0.00278	0	0
C13orf36	400120	broad.mit.edu	37	13	37269436	37269436	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:37269436C>T	uc001uvt.3	+	2	667	c.221C>T	c.(220-222)TCC>TTC	p.S74F		NM_203451	NP_982276	A2A2V5	CM036_HUMAN	hypothetical protein LOC400120	74	Poly-Ser.					integral to membrane				skin(1)	1						TCCTCCAGTTCCTCCTACCCA	0.448			NA											26	106					0	0	0.00333	0	0
SUCLA2	8803	broad.mit.edu	37	13	48528386	48528386	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:48528386C>A	uc001vbs.2	-	8	1053	c.996G>T	c.(994-996)ATG>ATT	p.M332I	SUCLA2_uc010tgb.1_Missense_Mutation_p.M272I|SUCLA2_uc010tgc.1_Missense_Mutation_p.M198I|SUCLA2_uc010tgd.1_Missense_Mutation_p.M272I|SUCLA2_uc001vbt.1_RNA	NM_003850	NP_003841	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	332					succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)	1		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	TTATTATATCCATTGTGGCCA	0.368			NA											11	50					3.27435e-08	3.77651e-08	0.00245	1	0
PCDH17	27253	broad.mit.edu	37	13	58208714	58208714	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:58208714G>C	uc001vhq.1	+	1	2926	c.2034G>C	c.(2032-2034)AAG>AAC	p.K678N	PCDH17_uc010aec.1_Missense_Mutation_p.K678N	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	678	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAGTGGCCAAGCTCATCATCC	0.652	Melanoma(72;952 1291 1619 12849 33676)		NA											33	78					0	0	0.002836	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369241	86369241	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:86369241T>C	uc001vll.1	-	2	1862	c.1403A>G	c.(1402-1404)AAC>AGC	p.N468S	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	468	Extracellular (Potential).|LRR 10.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GAGGAGGTTGTTATTTAAATA	0.333			NA											15	60					0	0	0.00245	0	0
SLC15A1	6564	broad.mit.edu	37	13	99340768	99340768	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:99340768G>A	uc001vno.2	-	19	1607	c.1530C>T	c.(1528-1530)ATC>ATT	p.I510I		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	510	Extracellular (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	TGTAGCTGCTGATGTTTGCAT	0.368			NA											11	35					0	0	0.008291	0	0
NALCN	259232	broad.mit.edu	37	13	101763510	101763510	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:101763510G>A	uc001vox.1	-	19	2449	c.2260C>T	c.(2260-2262)CTC>TTC	p.L754F		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	754	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGCACGCTGAGGATTGACCTC	0.512			NA											33	147					0	0	0.004878	0	0
COL4A2	1284	broad.mit.edu	37	13	111114675	111114675	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr13:111114675G>A	uc001vqx.2	+	24	2009	c.1720G>A	c.(1720-1722)GAT>AAT	p.D574N		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	574	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GAAAGGTGACGATGGCAGCCC	0.642			NA											14	42					0	0	0.004007	0	0
OR4E2	26686	broad.mit.edu	37	14	22133935	22133935	+	Silent	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:22133935C>G	uc010tmd.1	+	1	639	c.639C>G	c.(637-639)GCC>GCG	p.A213A		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GTTTCTTGGCCGTGGTCACCT	0.512			NA											26	39					0	0	0.00632	0	0
C14orf93	60686	broad.mit.edu	37	14	23465468	23465468	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:23465468C>T	uc001wib.1	-	3	917	c.607G>A	c.(607-609)GAT>AAT	p.D203N	C14orf93_uc001wic.1_Missense_Mutation_p.D23N|C14orf93_uc001wid.1_Missense_Mutation_p.D203N|C14orf93_uc001wig.2_Missense_Mutation_p.D203N|C14orf93_uc001wih.2_Missense_Mutation_p.D203N|C14orf93_uc001wie.2_Missense_Mutation_p.D203N|C14orf93_uc001wia.3_Missense_Mutation_p.D203N|C14orf93_uc001wif.2_Missense_Mutation_p.D23N	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	203						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		GCCACGTAATCATCCACCAGC	0.493			NA											22	26					0	0	0.00278	0	0
LRRC16B	90668	broad.mit.edu	37	14	24528901	24528901	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:24528901T>G	uc001wlj.2	+	22	1985	c.1828T>G	c.(1828-1830)TCT>GCT	p.S610A	LRRC16B_uc001wlk.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	610										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		GAACAATACATCTGCCCTGGG	0.597			NA											9	14					0	0	0.006214	0	0
NOVA1	4857	broad.mit.edu	37	14	26949326	26949326	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:26949326T>A	uc001wpy.2	-	3	622	c.304A>T	c.(304-306)ATC>TTC	p.I102F	NOVA1_uc001wpz.2_Missense_Mutation_p.I102F|NOVA1_uc001wqa.2_5'UTR|NOVA1_uc001wqb.2_Missense_Mutation_p.I102F	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	105	KH 1.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GTTCCCTGGATCAAGCACACT	0.378			NA											21	24					0	0	0.010504	0	0
STRN3	29966	broad.mit.edu	37	14	31416332	31416332	+	Missense_Mutation	SNP	C	C	A	rs145004284		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:31416332C>A	uc001wqu.2	-	5	896	c.680G>T	c.(679-681)GGT>GTT	p.G227V	STRN3_uc001wqv.2_Missense_Mutation_p.G227V|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	227					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		AGGAGATTCACCTCCATTCAG	0.328			NA											14	31					2.61681e-11	3.15051e-11	0.00245	1	0
C14orf28	122525	broad.mit.edu	37	14	45369754	45369754	+	Missense_Mutation	SNP	G	G	T	rs146051011	byFrequency	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:45369754G>T	uc001wvo.2	+	2	382	c.116G>T	c.(115-117)CGC>CTC	p.R39L	C14orf28_uc001wvp.1_Missense_Mutation_p.R39L	NM_001017923	NP_001017923	Q4W4Y0	CN028_HUMAN	hypothetical protein LOC122525	39										ovary(1)	1						AAAGCTGGCCGCAAAGCAGTA	0.363			NA											16	20					2.31682e-05	2.53879e-05	0.003163	1	0
FAM179B	23116	broad.mit.edu	37	14	45465012	45465012	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:45465012G>A	uc001wvv.2	+	2	2319	c.2110G>A	c.(2110-2112)GAT>AAT	p.D704N	FAM179B_uc001wvw.2_Missense_Mutation_p.D704N|FAM179B_uc010anc.2_RNA|FAM179B_uc010anb.1_Missense_Mutation_p.D704N|FAM179B_uc001wvu.2_Missense_Mutation_p.D704N	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	704							binding			skin(2)|upper_aerodigestive_tract(1)	3						GCCAGTCAATGATGATTTATG	0.318			NA											11	14					0	0	0.001855	0	0
C14orf104	55172	broad.mit.edu	37	14	50100361	50100361	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:50100361C>A	uc001wws.3	-	1	1588	c.1507G>T	c.(1507-1509)GGC>TGC	p.G503C	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.G503C	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	503					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					GAGCGCTGGCCGCCCGTGCCC	0.622			NA							Kartagener_syndrome				5	19					0.00116845	0.00123361	0.001168	1	0
KLHDC2	23588	broad.mit.edu	37	14	50245145	50245146	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:50245145_50245146GA>TT	uc001wwx.2	+	6	966_967	c.566_567GA>TT	c.(565-567)AGA>ATT	p.R189I	SDCCAG1_uc010anj.1_Intron|KLHDC2_uc001wwy.2_Missense_Mutation_p.R189I|KLHDC2_uc010anp.2_Missense_Mutation_p.R189I	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	189	Kelch 3.					nucleus	protein binding			ovary(1)	1	all_epithelial(31;0.000959)|Breast(41;0.0117)					AGTCATCCAAGAGGATGGAATG	0.322			NA											14	18					0	0	0.004672	0	0
SDCCAG1	9147	broad.mit.edu	37	14	50266231	50266231	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:50266231T>C	uc001wxc.2	-	25	2495	c.2427A>G	c.(2425-2427)AAA>AAG	p.K809K	SDCCAG1_uc010anj.1_Silent_p.K809K|SDCCAG1_uc001wwz.2_5'UTR|SDCCAG1_uc001wxa.2_Silent_p.K89K|SDCCAG1_uc010tqi.1_Silent_p.K788K|SDCCAG1_uc001wxe.2_Silent_p.K767K|SDCCAG1_uc001wxd.1_Silent_p.K214K	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	809						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		GGCTCTGTGATTTACTGTCAC	0.299			NA											35	39					0	0	0.004878	0	0
MUDENG	55745	broad.mit.edu	37	14	57741544	57741544	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:57741544C>T	uc001xcv.2	+	2	1084	c.657C>T	c.(655-657)TCC>TCT	p.S219S	MUDENG_uc001xcu.3_Silent_p.S219S|MUDENG_uc010tri.1_Intron|MUDENG_uc010trj.1_Silent_p.S116S	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	219	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						AGGTAAAATCCATGCAATATG	0.393			NA											20	29					0	0	0.012319	0	0
SYNE2	23224	broad.mit.edu	37	14	64494420	64494420	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:64494420A>T	uc001xgm.2	+	43	6853	c.6623A>T	c.(6622-6624)TAC>TTC	p.Y2208F	SYNE2_uc001xgl.2_Missense_Mutation_p.Y2208F	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2208	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGGGAAACTACCTCTTGGAG	0.418			NA											15	20					0	0	0.003163	0	0
LTBP2	4053	broad.mit.edu	37	14	74970292	74970292	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:74970292C>T	uc001xqa.2	-	32	4987	c.4600G>A	c.(4600-4602)GAC>AAC	p.D1534N		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1534	EGF-like 18; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CAGGCCAGGTCCTGGCACTCA	0.622			NA											6	7					0	0	0.001168	0	0
PROX2	283571	broad.mit.edu	37	14	75329988	75329988	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:75329988G>A	uc001xqr.1	-	1	550	c.550C>T	c.(550-552)CGC>TGC	p.R184C	PROX2_uc001xqq.1_Missense_Mutation_p.R110C	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	184					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		ACCCAGGGGCGAGGCCCACAG	0.617			NA											9	32					0	0	0.008291	0	0
TTC8	123016	broad.mit.edu	37	14	89291101	89291101	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:89291101G>T	uc010ath.2	+	1	184	c.50G>T	c.(49-51)CGC>CTC	p.R17L	TTC8_uc010atg.1_RNA|TTC8_uc001xxl.2_5'UTR|TTC8_uc010ati.2_5'UTR|TTC8_uc001xxm.2_Missense_Mutation_p.R17L|TTC8_uc010atj.2_Missense_Mutation_p.R17L|TTC8_uc001xxi.2_Missense_Mutation_p.R17L|TTC8_uc001xxj.2_Missense_Mutation_p.R17L|TTC8_uc001xxk.2_Missense_Mutation_p.R17L	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	17	TPR 1.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						TATTTTAGGCGCAGGAAGTTC	0.642			NA							Bardet-Biedl_syndrome				5	10					3.59834e-05	3.92741e-05	0.001168	1	0
C14orf159	80017	broad.mit.edu	37	14	91633606	91633606	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:91633606C>T	uc001xzb.2	+	6	909	c.141C>T	c.(139-141)TCC>TCT	p.S47S	C14orf159_uc010atu.1_Silent_p.S47S|C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Silent_p.S47S|C14orf159_uc001xyx.2_Silent_p.S47S|C14orf159_uc001xyw.2_Silent_p.S47S|C14orf159_uc001xzc.2_Silent_p.S47S|C14orf159_uc001xza.2_Silent_p.S47S|C14orf159_uc001xyv.2_Silent_p.S47S|C14orf159_uc001xyz.2_Intron|C14orf159_uc010twj.1_Silent_p.S47S|C14orf159_uc001xze.2_Silent_p.S47S	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	47						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		TGCCCAGGTCCCTTGCTCCAG	0.557			NA											65	46					0	0	0.00361	0	0
C14orf129	51527	broad.mit.edu	37	14	96848614	96848614	+	Silent	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:96848614A>T	uc001yfj.3	+	3	175	c.30A>T	c.(28-30)CTA>CTT	p.L10L	C14orf129_uc001yfl.2_Silent_p.L10L	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129	10						cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)		CCATGGAGCTAAGCAGTATGT	0.348			NA											19	20					0	0	0.006122	0	0
DLK1	8788	broad.mit.edu	37	14	101195281	101195281	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:101195281C>A	uc001yhs.3	+	3	293	c.140C>A	c.(139-141)CCT>CAT	p.P47H	DLK1_uc001yhu.3_Missense_Mutation_p.P47H	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	47	Extracellular (Potential).|EGF-like 1.			QP -> HV (in Ref. 1; CAA78163).|Missing (in Ref. 3; CAA35582).	multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				AGGTGCCAGCCTGGCTGGCAG	0.617			NA											91	109					5.62478e-27	7.36994e-27	0.00361	1	0
KIF26A	26153	broad.mit.edu	37	14	104640602	104640602	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:104640602G>T	uc001yos.3	+	11	2148	c.2148G>T	c.(2146-2148)GTG>GTT	p.V716V		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	716					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		TCAGCACCGTGCAGCTCGCCG	0.697			NA											4	3					0.00024832	0.000265229	0.009096	1	0
AHNAK2	113146	broad.mit.edu	37	14	105417947	105417947	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr14:105417947C>T	uc010axc.1	-	7	3961	c.3841G>A	c.(3841-3843)GAG>AAG	p.E1281K	AHNAK2_uc001ypx.2_Missense_Mutation_p.E1181K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1281						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCCGTCACCTCTGCCTTATGA	0.617			NA											103	84					0	0	0.00361	0	0
OR4M2	390538	broad.mit.edu	37	15	22368926	22368926	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:22368926G>A	uc010tzu.1	+	1	351	c.351G>A	c.(349-351)GTG>GTA	p.V117V	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGCTCACAGTGATGGCCTTTG	0.488			NA											73	501					0	0	0.00361	0	0
Unknown	0	broad.mit.edu	37	15	22440594	22440594	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:22440594C>T	uc001yug.2	-	1	272	c.253G>A	c.(253-255)GCA>ACA	p.A85T						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).												NA						TTATTAGATGCATTGTAGACA	0.473			NA											11	55					0	0	0.001368	0	0
MEIS2	4212	broad.mit.edu	37	15	37184626	37184626	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:37184626C>T	uc001zjr.2	-	12	2219	c.1182G>A	c.(1180-1182)CAG>CAA	p.Q394Q	MEIS2_uc001zjl.2_3'UTR|MEIS2_uc010ucj.1_Silent_p.Q374Q|MEIS2_uc001zjm.2_3'UTR|MEIS2_uc001zjn.2_3'UTR|MEIS2_uc001zjo.2_3'UTR|MEIS2_uc001zjp.2_3'UTR|MEIS2_uc001zjs.2_Silent_p.Q387Q|MEIS2_uc001zju.2_3'UTR|MEIS2_uc001zjt.2_Silent_p.Q387Q|MEIS2_uc001zjj.2_Silent_p.Q90Q|MEIS2_uc001zjk.2_Silent_p.Q83Q	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	394					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TAGGACCACCCTGAGAAACGT	0.458			NA											121	107					0	0	0.00361	0	0
MEIS2	4212	broad.mit.edu	37	15	37376025	37376025	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:37376025C>A	uc001zjr.2	-	7	1738	c.701G>T	c.(700-702)GGG>GTG	p.G234V	MEIS2_uc001zjl.2_Missense_Mutation_p.G221V|MEIS2_uc010ucj.1_Missense_Mutation_p.G221V|MEIS2_uc001zjm.2_Missense_Mutation_p.G146V|MEIS2_uc001zjn.2_Missense_Mutation_p.G88V|MEIS2_uc001zjo.2_Missense_Mutation_p.G234V|MEIS2_uc001zjp.2_Missense_Mutation_p.G234V|MEIS2_uc001zjs.2_Missense_Mutation_p.G234V|MEIS2_uc001zju.2_Missense_Mutation_p.G221V|MEIS2_uc001zjt.2_Missense_Mutation_p.G234V	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	234	Ser/Thr-rich.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		ACTGGAGGGCCCTGGGGTGCC	0.512			NA											36	46					1.15505e-17	1.46448e-17	0.009718	1	0
SPG11	80208	broad.mit.edu	37	15	44955723	44955723	+	Silent	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:44955723G>C	uc001ztx.2	-	1	154	c.123C>G	c.(121-123)CTC>CTG	p.L41L	SPG11_uc010ueh.1_Silent_p.L41L|SPG11_uc010uei.1_Silent_p.L41L|SPG11_uc001zua.1_Silent_p.L41L	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	41	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCCGGGAGCCGAGCTGCCCCA	0.726			NA											5	11					0	0	0.000602	0	0
SLC24A5	283652	broad.mit.edu	37	15	48413264	48413264	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:48413264C>T	uc001zwe.2	+	1	96	c.23C>T	c.(22-24)ACA>ATA	p.T8I	SLC24A5_uc001zwd.2_Missense_Mutation_p.T8I|SLC24A5_uc010bel.2_Missense_Mutation_p.T8I	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	8					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		GGGGGCCAAACATGGGCGAGA	0.572			NA											4	16					0	0	0.009096	0	0
USP8	9101	broad.mit.edu	37	15	50773724	50773724	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:50773724G>C	uc001zym.3	+	12	1765	c.1265G>C	c.(1264-1266)AGA>ACA	p.R422T	USP8_uc001zyk.1_Missense_Mutation_p.R123T|USP8_uc001zyl.3_Missense_Mutation_p.R422T|USP8_uc001zyn.3_Missense_Mutation_p.R422T|USP8_uc010ufh.1_Missense_Mutation_p.R345T|USP8_uc010bev.1_Missense_Mutation_p.R51T	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	422					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GAAGAGCATAGAATAAAATCT	0.378			NA											9	26					0	0	0.004482	0	0
WDR72	256764	broad.mit.edu	37	15	53992079	53992079	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:53992079C>T	uc002acj.2	-	13	1675	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K	WDR72_uc010bfi.1_Missense_Mutation_p.E545K	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	545	WD 7.									lung(1)|skin(1)	2				all cancers(107;0.0511)		CTCTTTCCCTCAAGGTGAAGG	0.453			NA											77	64					0	0	0.00361	0	0
HOMER2	9455	broad.mit.edu	37	15	83561536	83561536	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr15:83561536C>T	uc002bjg.2	-	2	249	c.63G>A	c.(61-63)AAG>AAA	p.K21K	HOMER2_uc002bjh.2_Silent_p.K21K|HOMER2_uc002bjj.2_Silent_p.K21K|HOMER2_uc002bji.2_Silent_p.K21K	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	21	WH1.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						TCCAGTTCTTCTTGGTGTTGG	0.522			NA											18	113					0	0	0.00499	0	0
CASKIN1	57524	broad.mit.edu	37	16	2233834	2233834	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:2233834C>T	uc010bsg.1	-	15	1557	c.1525G>A	c.(1525-1527)GAG>AAG	p.E509K		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	509	SAM 1.				signal transduction	cytoplasm				skin(2)	2						AAGCTCACCTCGGGAGTCATG	0.667			NA											12	54					0	0	0.010729	0	0
BTBD12	84464	broad.mit.edu	37	16	3634838	3634838	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:3634838T>G	uc002cvp.2	-	13	5298	c.4671A>C	c.(4669-4671)AAA>AAC	p.K1557N		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1557	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						TTATGGGCACTTTGGGGGGCA	0.502			NA						Direct_reversal_of_damage|Homologous_recombination	FanconAnemia				101	82					0	0	0.00361	0	0
TEKT5	146279	broad.mit.edu	37	16	10769983	10769983	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:10769983G>C	uc002czz.1	-	5	991	c.919C>G	c.(919-921)CAG>GAG	p.Q307E		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	307	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						CGCATGTTCTGAGAGTGTTTG	0.517			NA											11	46					0	0	0.001855	0	0
ACSM2B	348158	broad.mit.edu	37	16	20576009	20576009	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:20576009G>T	uc002dhj.3	-	3	369	c.159C>A	c.(157-159)CAC>CAA	p.H53Q	ACSM2B_uc002dhk.3_Missense_Mutation_p.H53Q|ACSM2B_uc010bwf.1_Missense_Mutation_p.H53Q	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	53					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TGTCAGCCCAGTGATCCAACA	0.413			NA											18	9					2.39556e-15	2.98901e-15	0.00278	1	0
PLK1	5347	broad.mit.edu	37	16	23690396	23690396	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:23690396G>A	uc002dlz.1	+	1	196	c.143G>A	c.(142-144)CGC>CAC	p.R48H		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	48					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		GTGGACCCACGCAGCCGGCGG	0.697	Colon(12;240 564 27038 33155)		NA											11	11					0	0	0.001368	0	0
GTF3C1	2975	broad.mit.edu	37	16	27506568	27506568	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:27506568T>C	uc002dov.1	-	15	2636	c.2596A>G	c.(2596-2598)ACC>GCC	p.T866A	GTF3C1_uc002dou.2_Missense_Mutation_p.T866A	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	866						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCCTCCCAGGTGACACCATCT	0.642			NA											35	48					0	0	0.003271	0	0
SH2B1	25970	broad.mit.edu	37	16	28878713	28878713	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:28878713C>A	uc002dri.2	+	5	1440	c.1001C>A	c.(1000-1002)GCC>GAC	p.A334D	uc010vct.1_Intron|SH2B1_uc010vdc.1_Missense_Mutation_p.A24D|SH2B1_uc002drj.2_Missense_Mutation_p.A334D|SH2B1_uc002drk.2_Missense_Mutation_p.A334D|SH2B1_uc002drl.2_Missense_Mutation_p.A334D|SH2B1_uc010vdd.1_5'UTR|SH2B1_uc010vde.1_Missense_Mutation_p.A334D|SH2B1_uc002drm.2_Missense_Mutation_p.A334D	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	334	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|PH.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						ACAACCACAGCCCTGGAGATG	0.552			NA											116	146					1.19196e-58	1.61976e-58	0.00361	1	0
SALL1	6299	broad.mit.edu	37	16	51174068	51174068	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:51174068A>G	uc010vgs.1	-	2	2096	c.2065T>C	c.(2065-2067)TCC>CCC	p.S689P	SALL1_uc010vgr.1_Missense_Mutation_p.S592P|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	689					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGAAGCTTGGACGTCTCTGAT	0.542	GBM(103;1352 1446 1855 4775 8890)		NA											40	112					0	0	0.007835	0	0
POLR2C	5432	broad.mit.edu	37	16	57503178	57503178	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:57503178C>T	uc002elt.1	+	5	446	c.360C>T	c.(358-360)CTC>CTT	p.L120L	POLR2C_uc010vhq.1_Silent_p.L120L	NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	120					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						CTCGAGACCTCATCTCCAACA	0.582			NA											9	95					0	0	0.004482	0	0
POLR2C	5432	broad.mit.edu	37	16	57503195	57503195	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:57503195G>A	uc002elt.1	+	5	463	c.377G>A	c.(376-378)CGG>CAG	p.R126Q	POLR2C_uc010vhq.1_Missense_Mutation_p.R126Q	NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	126					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						AACAGCCCCCGGGTCATTCCG	0.577			NA											28	65					0	0	0.004656	0	0
GPR97	222487	broad.mit.edu	37	16	57719568	57719568	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:57719568G>A	uc002emh.2	+	11	1373	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K	GPR97_uc010vhv.1_Missense_Mutation_p.E304K|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_Missense_Mutation_p.E32K	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	424	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CTGGTTCCGTGAAGGGACAAC	0.582			NA											20	119					0	0	0.00278	0	0
PDPR	55066	broad.mit.edu	37	16	70190514	70190514	+	Missense_Mutation	SNP	G	G	T	rs117263218	by1000genomes	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:70190514G>T	uc002eyf.1	+	19	3329	c.2372G>T	c.(2371-2373)CGG>CTG	p.R791L	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.R691L|PDPR_uc002eyg.1_Missense_Mutation_p.R458L|PDPR_uc002eyh.2_Missense_Mutation_p.R136L|PDPR_uc010vls.1_Missense_Mutation_p.R136L	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	791					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		CCCATTTACCGGAATGGGCAG	0.532			NA											47	151					7.77372e-23	1.00418e-22	0.00361	1	0
GAN	8139	broad.mit.edu	37	16	81348805	81348805	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr16:81348805C>G	uc002fgo.2	+	1	235	c.87C>G	c.(85-87)TTC>TTG	p.F29L		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	29					cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				AGTCTCGCTTCTGCGACGCGC	0.677	GBM(106;1239 1507 7582 9741 33976)		NA											3	5					0	0	0.004672	0	0
OR3A2	4995	broad.mit.edu	37	17	3181738	3181738	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:3181738G>T	uc002fvg.2	-	1	531	c.492C>A	c.(490-492)AAC>AAA	p.N164K		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	164	Helical; Name=4; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GGGTCAGTGCGTTGGTGAAGG	0.582	GBM(166;478 2018 3875 5042 31983)|Esophageal Squamous(77;407 1232 1405 14297 15272)		NA											57	63					2.18419e-29	2.87559e-29	0.00361	1	0
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:7578457C>A	uc002gim.2	-	5	667	c.473G>T	c.(472-474)CGC>CTC	p.R158L	TP53_uc002gig.1_Missense_Mutation_p.R158L|TP53_uc002gih.2_Missense_Mutation_p.R158L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26L|TP53_uc010cng.1_Missense_Mutation_p.R26L|TP53_uc002gii.1_Missense_Mutation_p.R26L|TP53_uc010cnh.1_Missense_Mutation_p.R158L|TP53_uc010cni.1_Missense_Mutation_p.R158L|TP53_uc002gij.2_Missense_Mutation_p.R158L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65L|TP53_uc002gio.2_Missense_Mutation_p.R26L|TP53_uc010vug.1_Missense_Mutation_p.R119L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	29					2.89027e-11	3.47212e-11	0.002299	1	0
MYH8	4626	broad.mit.edu	37	17	10299898	10299898	+	Silent	SNP	C	C	G	rs146773971		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:10299898C>G	uc002gmm.2	-	32	4595	c.4500G>C	c.(4498-4500)ACG>ACC	p.T1500T	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1500	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CTCTTCTTAGCGTTTCGAGTT	0.478			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				12	16					0	0	0.010729	0	0
COX10	1352	broad.mit.edu	37	17	14095532	14095532	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:14095532G>A	uc002gof.3	+	6	1126	c.922G>A	c.(922-924)GAT>AAT	p.D308N	COX10_uc010vvs.1_Missense_Mutation_p.D91N|COX10_uc010vvt.1_Missense_Mutation_p.D116N	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	308					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		GGGCAGCCTCGATGCTGGTAA	0.577			NA											8	46					0	0	0.004482	0	0
TRPV2	51393	broad.mit.edu	37	17	16326824	16326824	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:16326824G>T	uc002gpy.2	+	5	1034	c.667G>T	c.(667-669)GAT>TAT	p.D223Y	TRPV2_uc002gpz.2_Intron	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	223	Cytoplasmic (Potential).|Required for interaction with SLC50A1 (By similarity).|ANK 4.				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CAAGCAGTGGGATGTGGTAAG	0.612			NA											28	25					4.59853e-10	5.5002e-10	0.005443	1	0
MPRIP	23164	broad.mit.edu	37	17	17078657	17078657	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:17078657G>A	uc002gqu.1	+	19	2696	c.2640G>A	c.(2638-2640)CTG>CTA	p.L880L	MPRIP_uc002gqv.1_Silent_p.L880L|MPRIP_uc002gqw.1_Silent_p.L635L|MPRIP_uc002gqx.1_Silent_p.L1109L|MPRIP_uc002gqy.1_Silent_p.L1109L|MPRIP_uc010cpl.1_Intron|MPRIP_uc010cpm.1_Intron	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	880	Potential.					cytoplasm|cytoskeleton	actin binding				0						GGACGCTGCTGACTGGGGACG	0.632			NA											8	21					0	0	0.004482	0	0
Unknown	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:21730916G>T	uc002gyy.3	+	2	343	c.218G>T	c.(217-219)CGG>CTG	p.R73L						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						GTCCTGCGTCGGAGAGGTGGT	0.552			NA											5	75					1.23904e-05	1.36593e-05	0.000602	1	0
SLC13A2	9058	broad.mit.edu	37	17	26823582	26823582	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:26823582G>A	uc002hbh.2	+	11	1652	c.1585G>A	c.(1585-1587)GGG>AGG	p.G529R	SLC13A2_uc010wam.1_Missense_Mutation_p.G485R|SLC13A2_uc010wan.1_Missense_Mutation_p.G578R|SLC13A2_uc010wao.1_Missense_Mutation_p.G486R|SLC13A2_uc002hbi.2_Missense_Mutation_p.G458R	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	529	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CTTCTCTTTCGGGGACCTCAA	0.567			NA											15	102					0	0	0.003163	0	0
SUPT6H	6830	broad.mit.edu	37	17	27000441	27000441	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:27000441G>A	uc002hby.2	+	2	112	c.22G>A	c.(22-24)GAG>AAG	p.E8K	SUPT6H_uc010crt.2_Missense_Mutation_p.E8K	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	8	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TGTGGAAAGCGAGGCTGAGGA	0.468			NA											11	29					0	0	0.010729	0	0
ACCN1	40	broad.mit.edu	37	17	32483356	32483356	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:32483356A>G	uc002hhu.2	-	1	470	c.196T>C	c.(196-198)TAC>CAC	p.Y66H		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	66	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GAGAAGTAGTAGGACACCCTC	0.592			NA											11	41					0	0	0.010729	0	0
MED1	5469	broad.mit.edu	37	17	37584015	37584015	+	Silent	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:37584015G>C	uc002hrv.3	-	10	890	c.678C>G	c.(676-678)GTC>GTG	p.V226V	MED1_uc010wee.1_Silent_p.V54V|MED1_uc002hru.2_Silent_p.V226V	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	226	Interaction with ESR1.|Interaction with the Mediator complex.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CAGAAGGAGAGACATAGTACT	0.308	Pancreas(21;279 768 2492 4877 24026)		NA								HNSCC(31;0.082)			7	25					0	0	0.004482	0	0
MED24	9862	broad.mit.edu	37	17	38186033	38186033	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:38186033G>A	uc002htt.2	-	13	1547	c.1234C>T	c.(1234-1236)CGG>TGG	p.R412W	MED24_uc010wes.1_Missense_Mutation_p.R272W|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Missense_Mutation_p.R437W|MED24_uc002htu.2_Missense_Mutation_p.R399W|MED24_uc010cwn.2_Missense_Mutation_p.R399W|MED24_uc010weu.1_Missense_Mutation_p.R322W|MED24_uc010wev.1_Missense_Mutation_p.R362W|MED24_uc010wew.1_Missense_Mutation_p.R341W|MED24_uc010wex.1_Missense_Mutation_p.R117W	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	412					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					GGCTCCGCCCGGAGGATCAGC	0.572			NA											25	42					0	0	0.008361	0	0
HEXIM1	10614	broad.mit.edu	37	17	43226847	43226847	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:43226847C>T	uc002iig.2	+	1	2164	c.290C>T	c.(289-291)TCG>TTG	p.S97L		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	97					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GGGGACGACTCGTCCGCTGGC	0.652			NA									OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	22					0	0	0.001984	0	0
HOXB8	3218	broad.mit.edu	37	17	46691978	46691978	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:46691978T>G	uc002inw.2	-	1	324	c.89A>C	c.(88-90)CAG>CCG	p.Q30P		NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	30						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCAGGTCCTGGGCGAAGCC	0.572			NA											8	7					0	0	0.00308	0	0
ABCA8	10351	broad.mit.edu	37	17	66902184	66902184	+	Splice_Site	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:66902184C>A	uc002jhp.2	-	17	2457	c.2278_splice	c.e17+1	p.D760_splice	ABCA8_uc002jhq.2_Splice_Site_p.D800_splice|ABCA8_uc010wqq.1_Splice_Site_p.D800_splice|ABCA8_uc010wqr.1_Splice_Site_p.D739_splice|ABCA8_uc002jhr.2_Splice_Site_p.D800_splice	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8							integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ATTTTATTTACCCGATTCATT	0.333			NA											14	73					1.49906e-05	1.64927e-05	0.00245	1	0
LLGL2	3993	broad.mit.edu	37	17	73566162	73566162	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr17:73566162G>A	uc002joh.2	+	15	1854	c.1700G>A	c.(1699-1701)CGC>CAC	p.R567H	LLGL2_uc002joi.2_Missense_Mutation_p.R567H|LLGL2_uc010dgg.1_Missense_Mutation_p.R567H|LLGL2_uc002joj.2_Missense_Mutation_p.R556H|LLGL2_uc010wsd.1_Missense_Mutation_p.R194H	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	567	WD 9.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTGGCAGCCCGCTCAGGGCCC	0.672			NA											12	15					0	0	0.010729	0	0
NDC80	10403	broad.mit.edu	37	18	2610858	2610858	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:2610858G>A	uc002kli.2	+	16	1971	c.1789G>A	c.(1789-1791)GAG>AAG	p.E597K		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	597	Potential.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.|Interaction with NEK2 and ZWINT.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						TGGGTCTGTAGAGGTAAGTAT	0.348			NA											28	71					0	0	0.005443	0	0
PPP4R1	9989	broad.mit.edu	37	18	9595070	9595070	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:9595070A>G	uc002koe.1	-	3	252	c.134T>C	c.(133-135)TTG>TCG	p.L45S	PPP4R1_uc010wzo.1_Missense_Mutation_p.L2S|PPP4R1_uc002kod.1_Missense_Mutation_p.L28S|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	45	HEAT 2.				protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						CAGGGGCGTCAACATTTCATC	0.418	Melanoma(188;1232 2082 5061 11948 35994)		NA											21	48					0	0	0.002299	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21747364	21747364	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:21747364C>T	uc002kve.2	-	25	2638	c.2464G>A	c.(2464-2466)GAA>AAA	p.E822K	OSBPL1A_uc002kvd.2_Missense_Mutation_p.E309K|OSBPL1A_uc010xbc.1_Missense_Mutation_p.E440K	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	822					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					AATACACTTTCAGAATCCGGC	0.443			NA											17	166					0	0	0.006122	0	0
ZNF521	25925	broad.mit.edu	37	18	22805128	22805128	+	Silent	SNP	G	G	T	rs149662480		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:22805128G>T	uc002kvk.2	-	4	3001	c.2754C>A	c.(2752-2754)ATC>ATA	p.I918I	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.I918I|ZNF521_uc002kvl.2_Silent_p.I698I	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	918					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCTTTTTCACGATGGCACTTT	0.498			NA	T	PAX5	ALL								18	75					7.07596e-05	7.64705e-05	0.006122	1	0
ZNF521	25925	broad.mit.edu	37	18	22807050	22807050	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:22807050G>A	uc002kvk.2	-	4	1079	c.832C>T	c.(832-834)CGA>TGA	p.R278*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.R278*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.R58*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	278					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGGGCCGCTCGGTCCTCATTT	0.557			NA	T	PAX5	ALL								31	103					0	0	0.012213	0	0
DSC1	1823	broad.mit.edu	37	18	28710636	28710636	+	Silent	SNP	A	A	G	rs139389841		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:28710636A>G	uc002kwn.2	-	16	2788	c.2526T>C	c.(2524-2526)CAT>CAC	p.H842H	DSC1_uc002kwm.2_3'UTR|uc002kwo.1_5'Flank	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	842	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AGTCTTCACAATGTTTATGCT	0.398			NA											26	29					0	0	0.00632	0	0
DTNA	1837	broad.mit.edu	37	18	32374075	32374075	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:32374075G>A	uc010dmn.1	+	3	224	c.223G>A	c.(223-225)GAA>AAA	p.E75K	DTNA_uc002kxu.2_Missense_Mutation_p.E75K|DTNA_uc010xbx.1_Missense_Mutation_p.E75K|DTNA_uc002kxv.3_Missense_Mutation_p.E75K|DTNA_uc002kxw.2_Missense_Mutation_p.E75K|DTNA_uc002kxx.2_Missense_Mutation_p.E75K|DTNA_uc010dmj.2_Missense_Mutation_p.E75K|DTNA_uc002kxz.2_Missense_Mutation_p.E75K|DTNA_uc002kxy.2_Missense_Mutation_p.E75K|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.E75K|DTNA_uc002kyb.3_Missense_Mutation_p.E75K|DTNA_uc010dmm.2_Missense_Mutation_p.E75K	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	75	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						CCCAAACACTGAACTCAACGT	0.463			NA											8	45					0	0	0.006214	0	0
RTTN	25914	broad.mit.edu	37	18	67688031	67688031	+	Silent	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr18:67688031T>A	uc002lkp.2	-	45	6041	c.5973A>T	c.(5971-5973)TCA>TCT	p.S1991S	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.S1079S|RTTN_uc002lkn.2_5'UTR|RTTN_uc010dqp.2_Silent_p.S243S	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1991							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				GTCCACAACTTGACCAACAAA	0.438			NA											20	40					0	0	0.008871	0	0
THOP1	7064	broad.mit.edu	37	19	2790526	2790526	+	Missense_Mutation	SNP	G	G	A	rs142015327	byFrequency	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:2790526G>A	uc002lwj.2	+	2	279	c.124G>A	c.(124-126)GAG>AAG	p.E42K		NM_003249	NP_003240	P52888	THOP1_HUMAN	thimet oligopeptidase 1	42					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCTCATCGAGCAGACCAA	0.612			NA											11	44					0	0	0.008291	0	0
C19orf29	58509	broad.mit.edu	37	19	3623983	3623983	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:3623983T>C	uc002lyh.2	-	2	398	c.345A>G	c.(343-345)GCA>GCG	p.A115A	C19orf29_uc010dtn.2_5'Flank|C19orf29_uc002lyi.3_Silent_p.A115A|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	115						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGAGCTGGATGCTGAGGAGC	0.726			NA											8	10					0	0	0.00308	0	0
SAFB	6294	broad.mit.edu	37	19	5654150	5654150	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:5654150G>C	uc002mcf.2	+	12	1658	c.1605G>C	c.(1603-1605)AAG>AAC	p.K535N	SAFB_uc002mcg.2_Missense_Mutation_p.K535N|SAFB_uc002mce.3_Missense_Mutation_p.K535N|SAFB_uc010xir.1_Missense_Mutation_p.K535N|SAFB_uc010xis.1_Missense_Mutation_p.K466N|SAFB_uc010xit.1_Missense_Mutation_p.K378N|SAFB_uc010xiu.1_Missense_Mutation_p.K334N	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	535	Interaction with POLR2A.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		GTGGAGAAAAGAGTAAGGACC	0.448	Colon(88;338 1345 6184 8214 20897)		NA											14	15					0	0	0.00245	0	0
SLC25A41	284427	broad.mit.edu	37	19	6427134	6427134	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:6427134C>A	uc010dus.2	-	6	1006	c.920G>T	c.(919-921)CGC>CTC	p.R307L	KHSRP_uc002mer.3_5'Flank|SLC25A41_uc010dut.2_Missense_Mutation_p.R169L	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	307	Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						CATCCTGGTGCGCACCAGAGT	0.632			NA											4	8					0.000602214	0.000638254	0.000602	1	0
SLC25A23	79085	broad.mit.edu	37	19	6459599	6459599	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:6459599C>A	uc002mex.1	-	1	183	c.41G>T	c.(40-42)TGG>TTG	p.W14L	SLC25A23_uc002mev.2_RNA	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	14	Mitochondrial intermembrane (Potential).|EF-hand 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2						CAGGCGACCCCAGCGCTGCCG	0.577			NA											9	10					3.86212e-05	4.19862e-05	0.008291	1	0
INSR	3643	broad.mit.edu	37	19	7141783	7141783	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:7141783C>T	uc002mgd.1	-	13	2696	c.2587G>A	c.(2587-2589)GAG>AAG	p.E863K	INSR_uc002mge.1_Missense_Mutation_p.E851K	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	863	Fibronectin type-III 3.|Extracellular (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACGTTGTTCTCAAAGATTTCA	0.353			NA											10	56					0	0	0.008291	0	0
MUC16	94025	broad.mit.edu	37	19	9077470	9077470	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:9077470C>T	uc002mkp.2	-	3	10180	c.9976G>A	c.(9976-9978)GGG>AGG	p.G3326R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3327	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGACCAGTCCCTGTGATGCTT	0.517			NA											49	37					0	0	0.00361	0	0
MUC16	94025	broad.mit.edu	37	19	9082874	9082874	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:9082874C>A	uc002mkp.2	-	1	9145	c.8941G>T	c.(8941-8943)GGA>TGA	p.G2981*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2982	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCCCTGTTCCTGAAGTGGGG	0.498			NA											47	53					6.81593e-30	8.99506e-30	0.00361	1	0
RAVER1	125950	broad.mit.edu	37	19	10431489	10431489	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:10431489G>C	uc002moa.2	-	9	1743	c.1663C>G	c.(1663-1665)CCA>GCA	p.P555A	RAVER1_uc002mnz.2_5'Flank	NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CCCTCAGCTGGGCGGCGGCTT	0.697			NA											5	11					0	0	0.000602	0	0
USE1	55850	broad.mit.edu	37	19	17330079	17330079	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:17330079C>T	uc002nfo.2	+	7	540	c.480C>T	c.(478-480)CTC>CTT	p.L160L	USE1_uc010eal.1_Intron	NM_018467	NP_060937	Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog	160	Cytoplasmic (Potential).|Potential.				lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding				0						AGCTAGACCTCGTCCTGCAGC	0.557			NA											5	30					0	0	0.000602	0	0
CRLF1	9244	broad.mit.edu	37	19	18710483	18710483	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:18710483C>A	uc010ebt.1	-	2	483	c.289G>T	c.(289-291)GCT>TCT	p.A97S		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	97	Ig-like C2-type.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						AGGGCCAGAGCCAAGGTGGAG	0.692			NA											7	7					0.00198382	0.00208643	0.001984	1	0
ZNF676	163223	broad.mit.edu	37	19	22362910	22362910	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:22362910C>G	uc002nqs.1	-	3	1927	c.1609G>C	c.(1609-1611)GAA>CAA	p.E537Q		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	537	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTGCCACATTCTTCACATTTG	0.418			NA											14	43					0	0	0.003163	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769504	31769504	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:31769504G>A	uc002nsy.3	-	2	1260	c.1195C>T	c.(1195-1197)CAG>TAG	p.Q399*		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	399	C2H2-type 3; atypical.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GTGAGCTCCTGCAGGGTGTCA	0.572			NA											118	75					0	0	0.00361	0	0
PDCD5	9141	broad.mit.edu	37	19	33076808	33076808	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:33076808G>A	uc002ntm.2	+	4	317	c.253G>A	c.(253-255)GAG>AAG	p.E85K	PDCD5_uc002ntl.2_Missense_Mutation_p.E85K|PDCD5_uc010ede.2_Intron	NM_004708	NP_004699	O14737	PDCD5_HUMAN	programmed cell death 5	85					apoptosis|induction of apoptosis	cytoplasm|nucleus	DNA binding	p.E85D(1)		ovary(1)|lung(1)	2	Esophageal squamous(110;0.137)					ACAACTAAGTGAGAAGGTAAG	0.358			NA											75	42					0	0	0.00361	0	0
ZNF461	92283	broad.mit.edu	37	19	37130289	37130289	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:37130289G>A	uc002oem.2	-	6	1186	c.958C>T	c.(958-960)CAG>TAG	p.Q320*	ZNF461_uc002oen.2_Nonsense_Mutation_p.Q289*|ZNF461_uc010xtj.1_Nonsense_Mutation_p.Q297*	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	320	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TGAAGTCTCTGATGTTGAGTA	0.413			NA											8	30					0	0	0.00308	0	0
ZNF461	92283	broad.mit.edu	37	19	37130448	37130448	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:37130448G>A	uc002oem.2	-	6	1027	c.799C>T	c.(799-801)CAT>TAT	p.H267Y	ZNF461_uc002oen.2_Missense_Mutation_p.H236Y|ZNF461_uc010xtj.1_Missense_Mutation_p.H244Y	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	267	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCACCATTATGAATTCTTAGA	0.353			NA											6	39					0	0	0.001168	0	0
ZNF573	126231	broad.mit.edu	37	19	38229543	38229543	+	Silent	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:38229543C>A	uc002ohe.2	-	4	1870	c.1848G>T	c.(1846-1848)GGG>GGT	p.G616G	ZNF573_uc010efs.2_Silent_p.G529G|ZNF573_uc002ohd.2_Silent_p.G614G|ZNF573_uc002ohf.2_Silent_p.G558G|ZNF573_uc002ohg.2_Silent_p.G528G	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	596	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TGAAGGCCTTCCCACATTCTT	0.393			NA											77	31					1.07363e-35	1.44113e-35	0.00361	1	0
PRR19	284338	broad.mit.edu	37	19	42814213	42814213	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:42814213G>A	uc002oti.2	+	2	855	c.477G>A	c.(475-477)CAG>CAA	p.Q159Q	PRR19_uc002oth.1_Silent_p.Q159Q|PRR19_uc002otj.2_Silent_p.Q159Q	NM_199285	NP_954979	A6NJB7	PRR19_HUMAN	proline rich 19	159											0		Prostate(69;0.00682)				GTTTGCCACAGGCCTTCCCCC	0.632			NA											55	24					0	0	0.00361	0	0
PHLDB3	653583	broad.mit.edu	37	19	44005962	44005962	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:44005962C>T	uc002own.3	-	4	717	c.458G>A	c.(457-459)CGG>CAG	p.R153Q	PHLDB3_uc002owo.2_Missense_Mutation_p.R153Q	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	153	Potential.										0		Prostate(69;0.0153)				CTCCTCCTCCCGGCGAGCGGC	0.711			NA											13	10					0	0	0.001368	0	0
ZNF234	10780	broad.mit.edu	37	19	44661636	44661636	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:44661636C>A	uc002oym.2	+	6	1774	c.1467C>A	c.(1465-1467)TGC>TGA	p.C489*	ZNF234_uc002oyl.3_Nonsense_Mutation_p.C489*	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	489	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				GTGAAGAGTGCGGAAAGGGAT	0.453			NA											62	29					1.4709e-25	1.91356e-25	0.00361	1	0
ZNF227	7770	broad.mit.edu	37	19	44739918	44739918	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:44739918C>G	uc002oyu.2	+	6	1540	c.1335C>G	c.(1333-1335)TTC>TTG	p.F445L	ZNF227_uc010xwu.1_Missense_Mutation_p.F394L|ZNF227_uc002oyv.2_Missense_Mutation_p.F445L|ZNF227_uc010xwv.1_Missense_Mutation_p.F394L|ZNF227_uc010xww.1_Missense_Mutation_p.F366L|ZNF227_uc002oyw.2_Missense_Mutation_p.F417L|ZNF227_uc010ejh.2_Missense_Mutation_p.F438L|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	445	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				GTAAGGGCTTCAGCCACAATT	0.483			NA											37	73					0	0	0.004878	0	0
ZNF227	7770	broad.mit.edu	37	19	44740270	44740270	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:44740270C>G	uc002oyu.2	+	6	1892	c.1687C>G	c.(1687-1689)CTT>GTT	p.L563V	ZNF227_uc010xwu.1_Missense_Mutation_p.L512V|ZNF227_uc002oyv.2_Missense_Mutation_p.L563V|ZNF227_uc010xwv.1_Missense_Mutation_p.L512V|ZNF227_uc010xww.1_Missense_Mutation_p.L484V|ZNF227_uc002oyw.2_Missense_Mutation_p.L535V|ZNF227_uc010ejh.2_Missense_Mutation_p.L556V|ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_3'UTR	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	563	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				TAGTTCAAATCTTAAACTACA	0.408			NA											24	42					0	0	0.00333	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022063	51022063	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:51022063G>A	uc002pss.2	-	3	1044	c.907C>T	c.(907-909)CTC>TTC	p.L303F		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	303	Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		ACGCGCTCGAGGCGGTGCAGG	0.637			NA											87	44					0	0	0.00361	0	0
LILRA6	79168	broad.mit.edu	37	19	54744411	54744411	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:54744411G>T	uc002qeu.1	-	6	1121	c.997C>A	c.(997-999)CCC>ACC	p.P333T	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.P333T|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.P333T|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.P333T|LILRA6_uc010yeq.1_Missense_Mutation_p.P333T|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.P194T	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	333	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCCACTGTGGGGCCCGGCTGT	0.592			NA											33	48					1.07121e-22	1.3805e-22	0.006999	1	0
LILRA4	23547	broad.mit.edu	37	19	54849257	54849257	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:54849257G>T	uc002qfj.2	-	4	662	c.605C>A	c.(604-606)ACC>AAC	p.T202N	LILRA4_uc002qfi.2_Missense_Mutation_p.T136N	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	202	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CACGTATGGGGTGTTGTTTTC	0.552			NA											42	21					1.03325e-14	1.28337e-14	0.011902	1	0
ZNF835	90485	broad.mit.edu	37	19	57175427	57175427	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:57175427G>A	uc010ygo.1	-	2	1206	c.1206C>T	c.(1204-1206)CAC>CAT	p.H402H	ZNF835_uc010ygn.1_Silent_p.H380H	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GCACGAGGCGGTGCTGGAGGA	0.672			NA											33	28					0	0	0.012213	0	0
PEG3	5178	broad.mit.edu	37	19	57328382	57328382	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:57328382T>C	uc002qnu.2	-	7	1779	c.1428A>G	c.(1426-1428)AGA>AGG	p.R476R	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.R447R|PEG3_uc002qnv.2_Silent_p.R476R|PEG3_uc002qnw.2_Silent_p.R352R|PEG3_uc002qnx.2_Silent_p.R350R|PEG3_uc010etr.2_Silent_p.R476R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	476					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGAGGTTCTCTCTAGTATGCA	0.438			NA											118	54					0	0	0.00361	0	0
ZIM3	114026	broad.mit.edu	37	19	57646645	57646645	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr19:57646645C>A	uc002qnz.1	-	5	1446	c.1060G>T	c.(1060-1062)GAG>TAG	p.E354*		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	354	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAATTTTCTCATGATCGATG	0.383			NA											73	46					7.59065e-32	1.01147e-31	0.00361	1	0
PDIA6	10130	broad.mit.edu	37	2	10932003	10932003	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:10932003C>T	uc002rau.2	-	6	640	c.502G>A	c.(502-504)GAC>AAC	p.D168N	PDIA6_uc010yjg.1_Missense_Mutation_p.D165N|PDIA6_uc002rav.2_Missense_Mutation_p.D220N|PDIA6_uc010yjh.1_Missense_Mutation_p.D173N|PDIA6_uc002raw.2_Missense_Mutation_p.D216N	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	168	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		TCAAAGCTGTCGTCTGTCAGC	0.398	GBM(73;509 1219 34219 41343 41551)		NA											8	39					0	0	0.00308	0	0
BIRC6	57448	broad.mit.edu	37	2	32774406	32774406	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:32774406C>T	uc010ezu.2	+	65	13136	c.13002C>T	c.(13000-13002)GTC>GTT	p.V4334V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4334					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TAAATCCCGTCAGTAGTGCGG	0.383	Pancreas(94;175 1509 16028 18060 45422)		NA											6	86					0	0	0.001168	0	0
PNPT1	87178	broad.mit.edu	37	2	55912132	55912132	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:55912132G>C	uc002rzf.2	-	4	402	c.349C>G	c.(349-351)CTG>GTG	p.L117V	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	117					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCTCTTCTCAGATAGTTTGTG	0.353			NA											21	17					0	0	0.005443	0	0
USP34	9736	broad.mit.edu	37	2	61416060	61416060	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:61416060C>G	uc002sbe.2	-	79	10040	c.10018G>C	c.(10018-10020)GAA>CAA	p.E3340Q	USP34_uc002sbd.2_Missense_Mutation_p.E142Q	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3340					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GTTTTTCTTTCTTTGGCTTCT	0.408			NA											8	55					0	0	0.008291	0	0
USP34	9736	broad.mit.edu	37	2	61622131	61622131	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:61622131C>G	uc002sbe.2	-	5	632	c.610G>C	c.(610-612)GAA>CAA	p.E204Q		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	204					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			AATGGTACTTCTACATCCTGG	0.323			NA											12	7					0	0	0.010729	0	0
REG3A	5068	broad.mit.edu	37	2	79384798	79384798	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:79384798C>G	uc002sod.1	-	4	615	c.360G>C	c.(358-360)TGG>TGC	p.W120C	REG3A_uc002soe.1_Missense_Mutation_p.W120C|REG3A_uc002sof.1_Missense_Mutation_p.W120C	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	120	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						TACTCCACTCCCAACCTTCTC	0.552			NA											46	31					0	0	0.00361	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105892133	105892133	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:105892133C>T	uc002tcq.2	-	8	1633	c.1549G>A	c.(1549-1551)GTC>ATC	p.V517I	TGFBRAP1_uc010fjc.2_Missense_Mutation_p.V287I|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.V517I	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	517					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						GAGTCCTGGACATCGCCATTC	0.383	Esophageal Squamous(183;794 2019 9730 21801 48859)		NA											8	80					0	0	0.004482	0	0
SCTR	6344	broad.mit.edu	37	2	120219423	120219423	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:120219423C>A	uc002tma.2	-	7	1016	c.790G>T	c.(790-792)GGT>TGT	p.G264C	SCTR_uc002tlz.2_Missense_Mutation_p.G86C	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	264	Helical; Name=4; (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	AGAAACATACCCCATCCGAAT	0.333			NA											33	33					1.04594e-18	1.3323e-18	0.00623	1	0
THSD7B	80731	broad.mit.edu	37	2	137814327	137814327	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:137814327C>G	uc002tva.1	+	2	384	c.384C>G	c.(382-384)TGC>TGG	p.C128W	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.C18W	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATGAAATATGCGAACACTTTG	0.522			NA											86	94					0	0	0.00361	0	0
GALNT13	114805	broad.mit.edu	37	2	155098581	155098581	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:155098581C>T	uc002tyr.3	+	5	917	c.350C>T	c.(349-351)ACA>ATA	p.T117I	GALNT13_uc002tyt.3_Missense_Mutation_p.T117I|GALNT13_uc010foc.1_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	117	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CTTCCAAACACAAGTGTAGTC	0.353			NA											13	18					0	0	0.001855	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555914	155555914	+	Silent	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:155555914C>A	uc002tyv.1	+	1	822	c.627C>A	c.(625-627)CTC>CTA	p.L209L	KCNJ3_uc010zce.1_Silent_p.L209L	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	209	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	ACGGAAAACTCACGCTTATGT	0.592			NA											13	19					3.27435e-08	3.77651e-08	0.00245	1	0
PLA2R1	22925	broad.mit.edu	37	2	160898542	160898542	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:160898542C>A	uc002ube.1	-	3	868	c.661G>T	c.(661-663)GAT>TAT	p.D221Y	PLA2R1_uc010zcp.1_Missense_Mutation_p.D221Y|PLA2R1_uc002ubf.2_Missense_Mutation_p.D221Y	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	221	Extracellular (Potential).|Fibronectin type-II.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TTACTGGGATCAGGGCAAAAT	0.393			NA											53	42					2.01871e-26	2.63875e-26	0.00361	1	0
KBTBD10	10324	broad.mit.edu	37	2	170356080	170356080	+	Missense_Mutation	SNP	G	G	C	rs142007921		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:170356080G>C	uc010zdh.1	+	9	824	c.766G>C	c.(766-768)GTC>CTC	p.V256L	BBS5_uc002uet.2_Missense_Mutation_p.V256L|BBS5_uc010fpw.2_Missense_Mutation_p.V235L	NM_152384	NP_689597	O60662	KBTBA_HUMAN	Bardet-Biedl syndrome 5	Error:Variant_position_missing_in_O60662_after_alignment					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						ACTTCACAAAGTCTATTCTGC	0.333			NA											27	65					0	0	0.00632	0	0
TTN	7273	broad.mit.edu	37	2	179605651	179605651	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:179605651C>G	uc010zfh.1	-	46	12020	c.11796G>C	c.(11794-11796)TTG>TTC	p.L3932F	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.L3865F|TTN_uc010zfj.1_Missense_Mutation_p.L3740F|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGACTGCTCAATTCATTGG	0.398			NA											21	91					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179613632	179613632	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:179613632G>C	uc002unb.2	-	46	13719	c.13495C>G	c.(13495-13497)CAA>GAA	p.Q4499E	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTCTCTTTGCTTTAATGAA	0.313			NA											3	73					0	0	0.004672	0	0
CCDC141	285025	broad.mit.edu	37	2	179702304	179702304	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:179702304G>T	uc002unf.1	-	13	1974	c.1917C>A	c.(1915-1917)ATC>ATA	p.I639I	CCDC141_uc002une.1_Silent_p.I89I	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	639							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GAGGCAAGGAGATGTCATCAG	0.562			NA											4	69					0.00024832	0.000265229	0.009096	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803303	185803303	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:185803303G>T	uc002uph.2	+	4	3774	c.3180G>T	c.(3178-3180)ATG>ATT	p.M1060I		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1060						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AGCCAAACATGCTGGCCAACA	0.468			NA											80	41					2.05912e-35	2.75722e-35	0.00361	1	0
PLCL1	5334	broad.mit.edu	37	2	198950263	198950263	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:198950263G>A	uc010fsp.2	+	2	2313	c.2022G>A	c.(2020-2022)CCG>CCA	p.P674P	PLCL1_uc002uuv.3_Silent_p.P595P	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	674	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TTCAGACTCCGGGTCCAATGA	0.443			NA											20	76					0	0	0.008871	0	0
EEF1B2	1933	broad.mit.edu	37	2	207027266	207027266	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:207027266G>A	uc002vbf.1	+	6	609	c.451G>A	c.(451-453)GAT>AAT	p.D151N	EEF1B2_uc002vbg.1_Missense_Mutation_p.D151N|EEF1B2_uc002vbh.1_Missense_Mutation_p.D151N	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	151						cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						ACCTTGGGATGATGAGACAGA	0.378			NA											17	177					0	0	0.006122	0	0
PTH2R	5746	broad.mit.edu	37	2	209302497	209302497	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:209302497G>A	uc002vdb.2	+	4	515	c.302G>A	c.(301-303)CGA>CAA	p.R101Q	PTH2R_uc010zjb.1_Missense_Mutation_p.R112Q	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	101	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GTTGCTTTCCGACACTGTAAC	0.388			NA											42	19					0	0	0.013114	0	0
SPEG	10290	broad.mit.edu	37	2	220315959	220315959	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:220315959G>A	uc010fwg.2	+	5	2215	c.2215G>A	c.(2215-2217)GTG>ATG	p.V739M	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Translation_Start_Site|SPEG_uc002vln.1_Translation_Start_Site|SPEG_uc002vlp.1_Translation_Start_Site	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	739	Ig-like 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGGGGCAGATGTGCTGCTCAA	0.617			NA											6	106					0	0	0.001168	0	0
CHPF	79586	broad.mit.edu	37	2	220404716	220404716	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:220404716G>A	uc002vmc.3	-	4	1944	c.1717C>T	c.(1717-1719)CTG>TTG	p.L573L	CHPF_uc010zlh.1_Silent_p.L411L	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	573	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CGCCGCTCCAGCTCTGCCACG	0.662			NA											42	25					0	0	0.00361	0	0
MOGAT1	116255	broad.mit.edu	37	2	223559872	223559872	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:223559872G>T	uc010fws.1	+	5	766	c.718G>T	c.(718-720)GAA>TAA	p.E240*	MOGAT1_uc010fwt.1_Nonsense_Mutation_p.E200*	NM_058165	NP_477513	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	240					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		TGACAACCCTGAAGGATCATG	0.428	Ovarian(93;205 1446 2385 11581 25911)		NA											15	14					3.27435e-08	3.77651e-08	0.00245	1	0
SPHKAP	80309	broad.mit.edu	37	2	228881270	228881270	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:228881270C>T	uc002vpq.2	-	7	4347	c.4300G>A	c.(4300-4302)GAT>AAT	p.D1434N	SPHKAP_uc002vpp.2_Missense_Mutation_p.D1434N|SPHKAP_uc010zlx.1_Missense_Mutation_p.D1434N	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1434						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTCTCTGATCTGTTTCAATC	0.468			NA											38	29					0	0	0.003755	0	0
DGKD	8527	broad.mit.edu	37	2	234343033	234343033	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:234343033C>T	uc002vui.1	+	4	368	c.356C>T	c.(355-357)ACT>ATT	p.T119I	DGKD_uc002vuj.1_Missense_Mutation_p.T75I|DGKD_uc010fyh.1_5'UTR|DGKD_uc002vuk.1_5'UTR	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	119	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	TAGGTCATAACTCCATGCAGG	0.418			NA											7	131					0	0	0.00308	0	0
UGT1A7	54577	broad.mit.edu	37	2	234590805	234590805	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:234590805G>A	uc002vut.2	+	1	222	c.222G>A	c.(220-222)GTG>GTA	p.V74V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Silent_p.V74V	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	74					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		ATTGCACAGTGAAGACTTACT	0.527			NA											24	181					0	0	0.00333	0	0
COL6A3	1293	broad.mit.edu	37	2	238268032	238268032	+	Splice_Site	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:238268032C>T	uc002vwl.2	-	18	6568	c.6283_splice	c.e18-1	p.G2095_splice	COL6A3_uc002vwo.2_Splice_Site_p.G1889_splice|COL6A3_uc010znj.1_Splice_Site_p.G1488_splice	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCCGAGAGCCCTAGAAGGCAA	0.507			NA											24	140					0	0	0.003954	0	0
PRLH	51052	broad.mit.edu	37	2	238475665	238475665	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:238475665C>T	uc010znl.1	+	2	111	c.111C>T	c.(109-111)ATC>ATT	p.I37I		NM_015893	NP_056977	P81277	PRRP_HUMAN	prolactin releasing hormone precursor	37						extracellular region					0		Lung NSC(271;0.142)|all_lung(227;0.175)		Epithelial(121;8.28e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.03e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.19e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000329)|Lung(119;0.0106)|LUSC - Lung squamous cell carcinoma(224;0.0249)		CCCCTGACATCAATCCTGCCT	0.677			NA											30	50					0	0	0.008361	0	0
CAPN10	11132	broad.mit.edu	37	2	241528798	241528798	+	Silent	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:241528798A>T	uc002vzk.1	+	2	364	c.180A>T	c.(178-180)CCA>CCT	p.P60P	CAPN10_uc010zoh.1_Silent_p.P60P|CAPN10_uc002vzl.1_Silent_p.P60P|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_5'UTR|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Silent_p.P60P	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	60	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		CAGATGACCCACGGGAAGGGC	0.587			NA											17	159					0	0	0.006122	0	0
ANO7	50636	broad.mit.edu	37	2	242128153	242128153	+	Missense_Mutation	SNP	G	G	C	rs150079713		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr2:242128153G>C	uc002wax.2	+	1	230	c.127G>C	c.(127-129)GAG>CAG	p.E43Q	ANO7_uc002waw.2_Missense_Mutation_p.E43Q	NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	43	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CATGACCTCCGAGACCTCTTC	0.677			NA											6	41					0	0	0.001168	0	0
RRBP1	6238	broad.mit.edu	37	20	17622538	17622538	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:17622538C>T	uc002wpv.1	-	6	1143	c.789G>A	c.(787-789)GCG>GCA	p.A263A	RRBP1_uc002wpu.2_Silent_p.A37A|RRBP1_uc002wpw.1_Silent_p.A263A|RRBP1_uc010gcl.1_Silent_p.A37A	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	696	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						GTTTCAGAATCGCCACAGGGT	0.547			NA											46	62					0	0	0.00361	0	0
REM1	28954	broad.mit.edu	37	20	30065683	30065683	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:30065683G>A	uc002wwa.2	+	3	677	c.393G>A	c.(391-393)GTG>GTA	p.V131V		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	131					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCACACTGGTGGTCGTGGACA	0.567			NA											11	13					0	0	0.00245	0	0
BCL2L1	598	broad.mit.edu	37	20	30309796	30309796	+	Missense_Mutation	SNP	C	C	G	rs138364013		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:30309796C>G	uc002wwl.2	-	2	592	c.226G>C	c.(226-228)GAT>CAT	p.D76H	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Missense_Mutation_p.D76H|BCL2L1_uc002wwn.2_Missense_Mutation_p.D76H|BCL2L1_uc002wwo.1_Missense_Mutation_p.D76H	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	76					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			TCCCGGGCATCCAAACTGCTG	0.622	Colon(51;693 1004 1401 20431 21026)		NA											20	67					0	0	0.007413	0	0
ACSS2	55902	broad.mit.edu	37	20	33500968	33500968	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:33500968C>T	uc002xbd.2	+	3	565	c.444C>T	c.(442-444)TTC>TTT	p.F148F	ACSS2_uc002xbc.2_Silent_p.F53F|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Silent_p.F148F|ACSS2_uc002xbe.2_Intron|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	148					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGTGTCAGTTCAGCAATGTTC	0.532			NA											14	81					0	0	0.001855	0	0
C20orf152	140894	broad.mit.edu	37	20	34583046	34583046	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:34583046T>C	uc002xes.1	+	8	1098	c.942T>C	c.(940-942)GAT>GAC	p.D314D	C20orf152_uc002xer.1_Silent_p.D314D|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	314											0	Breast(12;0.00631)					AGCTGATAGATGGCAGACCTC	0.597			NA									OREG0025897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	50					0	0	0.010504	0	0
B4GALT5	9334	broad.mit.edu	37	20	48260100	48260100	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:48260100C>T	uc002xuu.3	-	4	646	c.452G>A	c.(451-453)GGT>GAT	p.G151D		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	151	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			CTTCCAGTGACCTCCGAGCTT	0.493			NA											19	81					0	0	0.010504	0	0
COL20A1	57642	broad.mit.edu	37	20	61937232	61937232	+	Splice_Site	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:61937232G>A	uc011aau.1	+	5	438	c.338_splice	c.e5-1	p.I113_splice	COL20A1_uc011aav.1_5'Flank	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1						cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TCTCCCTGCAGTTGAGGATCT	0.657			NA											10	43					0	0	0.008291	0	0
ZGPAT	84619	broad.mit.edu	37	20	62366802	62366802	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:62366802G>T	uc002ygk.2	+	6	1521	c.1343G>T	c.(1342-1344)AGC>ATC	p.S448I	ZGPAT_uc002ygi.2_Missense_Mutation_p.S428I|ZGPAT_uc002ygj.2_Missense_Mutation_p.S428I|ZGPAT_uc010gkk.1_Missense_Mutation_p.S5I|ZGPAT_uc010gkl.1_Missense_Mutation_p.S428I|ZGPAT_uc002ygm.2_Missense_Mutation_p.S419I|ZGPAT_uc002ygn.3_RNA|LIME1_uc011abi.1_5'Flank|LIME1_uc002ygp.3_5'Flank	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	448					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					TACCATGCCAGCAAGAGTGCC	0.627			NA											9	15					7.48243e-07	8.50487e-07	0.006214	1	0
CHAF1B	8208	broad.mit.edu	37	21	37775077	37775077	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr21:37775077C>T	uc002yvj.2	+	8	823	c.685C>T	c.(685-687)CAC>TAC	p.H229Y		NM_005441	NP_005432	Q13112	CAF1B_HUMAN	chromatin assembly factor 1 subunit B	229	WD 5.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			ovary(1)|skin(1)	2						CCGGATGTTTCACGACGACAG	0.393			NA											39	200					0	0	0.013114	0	0
ICOSLG	23308	broad.mit.edu	37	21	45651216	45651216	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr21:45651216G>A	uc002zee.2	-	5	943	c.809C>T	c.(808-810)GCG>GTG	p.A270V	ICOSLG_uc011afc.1_Missense_Mutation_p.A180V|ICOSLG_uc002zef.2_Missense_Mutation_p.A153V|ICOSLG_uc010gpp.1_Missense_Mutation_p.A270V	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	270	Helical; (Potential).				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		TATGGCCACCGCCACGACCAC	0.572			NA											24	52					0	0	0.00333	0	0
COL6A2	1292	broad.mit.edu	37	21	47533965	47533965	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr21:47533965C>A	uc002zia.1	+	5	861	c.779C>A	c.(778-780)CCC>CAC	p.P260H	COL6A2_uc002zhy.1_Missense_Mutation_p.P260H|COL6A2_uc002zhz.1_Missense_Mutation_p.P260H|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	260	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCCTCTGGCCCCAAGGGCTAC	0.532			NA											12	59					0.00316338	0.00332064	0.003163	1	0
PCNT	5116	broad.mit.edu	37	21	47836669	47836669	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr21:47836669C>T	uc002zji.3	+	30	6944	c.6837C>T	c.(6835-6837)TCC>TCT	p.S2279S	PCNT_uc002zjj.2_Silent_p.S2161S	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2279					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGCTTTGTTCCCCAGGCGTGT	0.687			NA											22	36					0	0	0.002299	0	0
PRAME	23532	broad.mit.edu	37	22	22892468	22892468	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:22892468C>T	uc002zwf.2	-	4	789	c.633G>A	c.(631-633)AAG>AAA	p.K211K	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Silent_p.K195K|PRAME_uc010gtr.2_Silent_p.K211K|PRAME_uc002zwg.2_Silent_p.K211K|PRAME_uc002zwh.2_Silent_p.K211K|PRAME_uc002zwi.2_Silent_p.K211K|PRAME_uc002zwj.2_Silent_p.K211K|PRAME_uc002zwk.2_Silent_p.K211K	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	211					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		TCTTCAGCTTCTTACAGCACA	0.433	Melanoma(73;1707 1838 15168 27201)		NA											13	79					0	0	0.001368	0	0
MYO18B	84700	broad.mit.edu	37	22	26343735	26343735	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:26343735G>C	uc003abz.1	+	36	5939	c.5689G>C	c.(5689-5691)GAT>CAT	p.D1897H	MYO18B_uc003aca.1_Missense_Mutation_p.D1778H|MYO18B_uc010guy.1_Missense_Mutation_p.D1779H|MYO18B_uc010guz.1_Missense_Mutation_p.D1777H|MYO18B_uc011aka.1_Missense_Mutation_p.D1051H|MYO18B_uc011akb.1_Missense_Mutation_p.D1410H	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1897	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GAAGCGCATCGATGAGGACCA	0.552			NA											11	27					0	0	0.001855	0	0
DEPDC5	9681	broad.mit.edu	37	22	32193597	32193597	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:32193597A>T	uc003als.2	+	13	921	c.779A>T	c.(778-780)CAG>CTG	p.Q260L	DEPDC5_uc011als.1_Missense_Mutation_p.Q260L|DEPDC5_uc011alu.1_Missense_Mutation_p.Q260L|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.Q260L|DEPDC5_uc003alr.1_Missense_Mutation_p.Q260L|DEPDC5_uc011alt.1_Missense_Mutation_p.Q232L	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	260					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						GTGGTGGTGCAGAATGAGAGA	0.313			NA											14	42					0	0	0.003163	0	0
TNRC6B	23112	broad.mit.edu	37	22	40658159	40658159	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:40658159G>A	uc011aor.1	+	4	650	c.439G>A	c.(439-441)GAG>AAG	p.E147K	TNRC6B_uc003aym.2_Missense_Mutation_p.E183K|TNRC6B_uc003ayn.3_Missense_Mutation_p.E147K|TNRC6B_uc003ayo.2_5'Flank	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	147					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GCTGCAGAGTGAGAGTGGGAC	0.572			NA											4	13					0	0	0.009096	0	0
XRCC6	2547	broad.mit.edu	37	22	42054269	42054269	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:42054269G>C	uc003bao.1	+	11	1505	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q	XRCC6_uc003bap.1_Missense_Mutation_p.E438Q|XRCC6_uc011apc.1_Missense_Mutation_p.E429Q|XRCC6_uc003baq.1_Missense_Mutation_p.E479Q|XRCC6_uc003bar.1_Missense_Mutation_p.E479Q|XRCC6_uc003bas.1_Missense_Mutation_p.E429Q	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	479					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						TGACAGCTTTGAGAACCCCGT	0.428			NA						Direct_reversal_of_damage|NHEJ					8	83					0	0	0.006214	0	0
EFCAB6	64800	broad.mit.edu	37	22	44022376	44022376	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:44022376A>C	uc003bdy.1	-	20	2631	c.2416T>G	c.(2416-2418)TGT>GGT	p.C806G	EFCAB6_uc003bdz.1_Missense_Mutation_p.C654G|EFCAB6_uc010gzi.1_Missense_Mutation_p.C654G|EFCAB6_uc010gzj.1_Missense_Mutation_p.C104G|EFCAB6_uc010gzk.1_RNA	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	806					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				CTCTTCTCACACAAATTTTGA	0.453			NA											16	29					0	0	0.003163	0	0
MAPK12	6300	broad.mit.edu	37	22	50693762	50693762	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:50693762C>T	uc003bkm.1	-	11	1039	c.888G>A	c.(886-888)GCG>GCA	p.A296A	MAPK12_uc003bkn.2_Silent_p.A115A|MAPK12_uc003bko.2_Silent_p.A206A|MAPK12_uc003bkl.1_Silent_p.A286A|MAPK12_uc003bkp.2_Silent_p.A81A|MAPK12_uc003bkq.2_Silent_p.A115A	NM_002969	NP_002960	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	296	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCCGCTGCTCCGCGTCCAGCA	0.657			NA											18	129					0	0	0.008871	0	0
GRM7	2917	broad.mit.edu	37	3	7503304	7503304	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:7503304C>T	uc003bqm.2	+	7	1684	c.1410C>T	c.(1408-1410)AAC>AAT	p.N470N	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.N470N|GRM7_uc003bql.2_Silent_p.N470N|GRM7_uc003bqn.1_Silent_p.N53N|GRM7_uc010hch.1_Translation_Start_Site	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	470	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TTAACAAGAACGGGGATGCAC	0.448			NA											5	102					0	0	0.001168	0	0
RAD18	56852	broad.mit.edu	37	3	8977576	8977576	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:8977576C>G	uc003brd.2	-	7	945	c.868G>C	c.(868-870)GAT>CAT	p.D290H	RAD18_uc003bre.2_RNA	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	290					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		TGCAAAGCATCGCATTGGGCA	0.328			NA						Rad6_pathway					9	44					0	0	0.006214	0	0
RFTN1	23180	broad.mit.edu	37	3	16411594	16411594	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:16411594C>G	uc003cay.2	-	6	1301	c.1019G>C	c.(1018-1020)GGA>GCA	p.G340A	RFTN1_uc010hes.2_Missense_Mutation_p.G304A	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	340						plasma membrane				ovary(3)|central_nervous_system(1)	4						ATTCACTATTCCAAGGTAGAA	0.493			NA											13	55					0	0	0.001368	0	0
KCNH8	131096	broad.mit.edu	37	3	19575181	19575181	+	Silent	SNP	C	C	A	rs138763434	byFrequency	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:19575181C>A	uc003cbk.1	+	16	3109	c.2914C>A	c.(2914-2916)CGA>AGA	p.R972R	KCNH8_uc010hex.1_Silent_p.R433R	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	972	Ser-rich.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CAGCCCCCAACGAACTGGAGC	0.493	NSCLC(124;1625 1765 8018 24930 42026)		NA											17	65					2.94398e-08	3.43152e-08	0.007413	1	0
NEK10	152110	broad.mit.edu	37	3	27161315	27161315	+	Silent	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:27161315T>A	uc010hfk.2	-	14	1462	c.1233A>T	c.(1231-1233)ACA>ACT	p.T411T	NEK10_uc010hfj.2_Silent_p.T354T			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	1099							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GGTAATCTGCTGTGAAAAAGT	0.423			NA											10	59					0	0	0.008291	0	0
NEK10	152110	broad.mit.edu	37	3	27243978	27243978	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:27243978G>T	uc010hfk.2	-	3	326	c.97C>A	c.(97-99)CAG>AAG	p.Q33K	NEK10_uc003cds.1_Missense_Mutation_p.Q118K|NEK10_uc010hfj.2_Missense_Mutation_p.Q33K			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	721							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GTCGCCATCTGATAAAGGATG	0.493			NA											6	35					0.00198382	0.00208643	0.001984	1	0
NEK10	152110	broad.mit.edu	37	3	27243984	27243985	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:27243984_27243985GG>AA	uc010hfk.2	-	3	319_320	c.90_91CC>TT	c.(88-93)ATCCTT>ATTTTT	p.L31F	NEK10_uc003cds.1_Missense_Mutation_p.L116F|NEK10_uc010hfj.2_Missense_Mutation_p.L31F			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	719							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						ATCTGATAAAGGATGCAGCCTA	0.49			NA											6	36					0	0	0.004672	0	0
SLC4A7	9497	broad.mit.edu	37	3	27473044	27473044	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:27473044T>C	uc003cdv.2	-	7	939	c.868A>G	c.(868-870)AGA>GGA	p.R290G	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_Intron|SLC4A7_uc003cdu.3_Intron|SLC4A7_uc011aww.1_Missense_Mutation_p.R299G|SLC4A7_uc011awx.1_Missense_Mutation_p.R286G|SLC4A7_uc011awy.1_Missense_Mutation_p.R282G|SLC4A7_uc011awz.1_Intron|SLC4A7_uc011axa.1_Intron|SLC4A7_uc011axb.1_Missense_Mutation_p.R286G|SLC4A7_uc010hfm.2_Intron|SLC4A7_uc003cdw.2_Intron	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	290	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						GTTCCAGCTCTTGAAGAAGGA	0.527			NA											14	45					0	0	0.003163	0	0
TRANK1	9881	broad.mit.edu	37	3	36893753	36893753	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:36893753C>T	uc003cgj.2	-	4	3153	c.2851G>A	c.(2851-2853)GGC>AGC	p.G951S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1501					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TCAAAGAGGCCAGAATCCCTT	0.438			NA											9	19					0	0	0.004482	0	0
TRANK1	9881	broad.mit.edu	37	3	36896851	36896851	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:36896851G>A	uc003cgj.2	-	3	2882	c.2580C>T	c.(2578-2580)ATC>ATT	p.I860I		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1410					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TGGGGTCATTGATGCATTTCA	0.557			NA											32	93					0	0	0.009535	0	0
CX3CR1	1524	broad.mit.edu	37	3	39306967	39306967	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:39306967T>A	uc003cjl.2	-	2	1126	c.1034A>T	c.(1033-1035)CAC>CTC	p.H345L		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	345	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		ATCACTCGTGTGGTAAGTAAA	0.498			NA											30	91					0	0	0.012213	0	0
LTF	4057	broad.mit.edu	37	3	46496868	46496868	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:46496868C>T	uc003cpq.2	-	5	602	c.564G>A	c.(562-564)CTG>CTA	p.L188L	LTF_uc003fzr.2_Silent_p.L144L|LTF_uc010hjh.2_Silent_p.L188L|LTF_uc003cpr.2_Silent_p.L175L	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	188	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	ACAGGCGACACAGGTTGGGGA	0.552			NA											12	28					0	0	0.010729	0	0
SETD2	29072	broad.mit.edu	37	3	47088029	47088029	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:47088029G>C	uc003cqs.2	-	16	7099	c.7046C>G	c.(7045-7047)GCC>GGC	p.A2349G	SETD2_uc003cqv.2_Missense_Mutation_p.A2416G|SETD2_uc003cqr.2_5'UTR	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2349	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CACTGCTGCGGCTGGCTGTAC	0.463			NA	N|F|S|Mis		clear cell renal carcinoma								9	36					0	0	0.006214	0	0
SCAP	22937	broad.mit.edu	37	3	47458687	47458687	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:47458687G>A	uc003crh.1	-	18	3236	c.2981C>T	c.(2980-2982)GCC>GTC	p.A994V	SCAP_uc011baz.1_Missense_Mutation_p.A738V|SCAP_uc003crg.2_Missense_Mutation_p.A601V	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	994	Interaction with SREBF2 (By similarity).|Cytoplasmic (By similarity).|WD 2.			A -> S (in Ref. 6; BAC11673).	cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		CCCTTCAATGGCGTCCCACAC	0.632	Pancreas(149;978 1908 29304 37806 46700)		NA											6	25					0	0	0.001168	0	0
CELSR3	1951	broad.mit.edu	37	3	48678894	48678894	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:48678894C>T	uc003cul.2	-	33	9169	c.8888G>A	c.(8887-8889)TGT>TAT	p.C2963Y	CELSR3_uc003cuf.1_Missense_Mutation_p.C3061Y|CELSR3_uc010hkf.2_Missense_Mutation_p.C253Y|CELSR3_uc010hkg.2_Missense_Mutation_p.C946Y	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2963	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGCAGAGCACAGGGGGCTGC	0.622			NA											11	56					0	0	0.001855	0	0
ABHD14B	84836	broad.mit.edu	37	3	52004084	52004084	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:52004084G>A	uc003dcm.2	-	3	1216	c.328C>T	c.(328-330)CCA>TCA	p.P110S	PCBP4_uc003dch.1_5'Flank|PCBP4_uc003dci.1_5'Flank|PCBP4_uc003dcj.1_5'Flank|PCBP4_uc003dck.1_5'Flank|ABHD14B_uc010hly.2_Intron|ABHD14B_uc011bdy.1_Missense_Mutation_p.P110S|ABHD14B_uc003dcn.2_Missense_Mutation_p.P110S|ABHD14B_uc011bdz.1_Missense_Mutation_p.P110S	NM_032750	NP_116139	Q96IU4	ABHEB_HUMAN	abhydrolase domain containing 14B	110						cytoplasm|nucleus	hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000548)|KIRC - Kidney renal clear cell carcinoma(197;0.00072)		CTCAGTGATGGACTGATCACA	0.647			NA											14	33					0	0	0.001855	0	0
CACNA1D	776	broad.mit.edu	37	3	53810922	53810922	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:53810922T>A	uc003dgv.3	+	37	4689	c.4526T>A	c.(4525-4527)CTT>CAT	p.L1509H	CACNA1D_uc003dgu.3_Missense_Mutation_p.L1529H|CACNA1D_uc003dgy.3_Missense_Mutation_p.L1494H|CACNA1D_uc003dgw.3_Missense_Mutation_p.L1176H|CACNA1D_uc003dgx.1_Missense_Mutation_p.L685H	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1509	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GTCACTCTGCTTCGACGCATC	0.522			NA											11	25					0	0	0.001368	0	0
CCDC66	285331	broad.mit.edu	37	3	56627757	56627757	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:56627757G>A	uc003dhz.2	+	9	1394	c.1307G>A	c.(1306-1308)AGT>AAT	p.S436N	CCDC66_uc003dhy.2_Missense_Mutation_p.S72N|CCDC66_uc003dhu.2_Missense_Mutation_p.S402N|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	436										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		ATGGCAAACAGTAAGAAAACA	0.378			NA											6	31					0	0	0.001168	0	0
EPHA3	2042	broad.mit.edu	37	3	89468424	89468424	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:89468424A>G	uc003dqy.2	+	11	2183	c.1958A>G	c.(1957-1959)AAG>AGG	p.K653R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	653	Cytoplasmic (Potential).|Protein kinase.	ATP (By similarity).				extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTGGCCATTAAGACCCTGAAA	0.428			NA								TSP Lung(6;0.00050)			7	30					0	0	0.001984	0	0
EPHA3	2042	broad.mit.edu	37	3	89498443	89498443	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:89498443C>G	uc003dqy.2	+	14	2640	c.2415C>G	c.(2413-2415)AGC>AGG	p.S805R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	805	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CGTCAGCCAGCGATGTATGGA	0.438			NA								TSP Lung(6;0.00050)			13	60					0	0	0.00245	0	0
DCBLD2	131566	broad.mit.edu	37	3	98520492	98520492	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:98520492T>G	uc003dtd.2	-	14	2035	c.1672A>C	c.(1672-1674)AAG>CAG	p.K558Q	DCBLD2_uc003dte.2_Missense_Mutation_p.K558Q	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	558	Cytoplasmic (Potential).				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						GTTTTTTTCTTTCTGGAAAAA	0.333			NA											3	10					0	0	0.009096	0	0
DCBLD2	131566	broad.mit.edu	37	3	98538181	98538181	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:98538181C>G	uc003dtd.2	-	8	1315	c.952G>C	c.(952-954)GAC>CAC	p.D318H	DCBLD2_uc003dte.2_Missense_Mutation_p.D318H	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	318	Extracellular (Potential).|F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						CCTGTGTGGTCAGTCCACTCC	0.483			NA											8	40					0	0	0.006214	0	0
IMPG2	50939	broad.mit.edu	37	3	100951668	100951668	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:100951668C>G	uc003duq.1	-	15	3393	c.3190G>C	c.(3190-3192)GAT>CAT	p.D1064H	IMPG2_uc011bhe.1_Missense_Mutation_p.D927H|IMPG2_uc010hpj.1_RNA	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1064	Extracellular (Potential).|EGF-like 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CACTTTCCATCATTCAAGCAG	0.458			NA											16	35					0	0	0.004007	0	0
CCDC54	84692	broad.mit.edu	37	3	107096565	107096565	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:107096565G>A	uc003dwi.1	+	1	378	c.131G>A	c.(130-132)GGA>GAA	p.G44E		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	44											0						GATTCAACTGGATATCCCACT	0.398			NA											27	53					0	0	0.008361	0	0
DPPA4	55211	broad.mit.edu	37	3	109049546	109049546	+	Silent	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:109049546C>A	uc003dxq.3	-	5	559	c.504G>T	c.(502-504)GTG>GTT	p.V168V	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Silent_p.V168V	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	168						nucleus	protein binding			upper_aerodigestive_tract(1)	1						GAGGAAGAGCCACTTCAGGAG	0.498			NA											20	65					4.35082e-09	5.12575e-09	0.010504	1	0
PVRL3	25945	broad.mit.edu	37	3	110831156	110831156	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:110831156T>A	uc003dxt.1	+	2	440	c.440T>A	c.(439-441)ATC>AAC	p.I147N	PVRL3_uc003dxu.1_Missense_Mutation_p.I124N	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	147	Extracellular (Potential).|Ig-like V-type.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						GGAAAATACATCTGCAAAGCT	0.373			NA											16	24					0	0	0.007413	0	0
POLQ	10721	broad.mit.edu	37	3	121202241	121202241	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:121202241C>G	uc003eee.3	-	18	6091	c.5962G>C	c.(5962-5964)GAT>CAT	p.D1988H	POLQ_uc003eed.2_Missense_Mutation_p.D1160H	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1988					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		ACCTTAGGATCTTCATAACTT	0.299	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					4	22					0	0	0.009096	0	0
MYLK	4638	broad.mit.edu	37	3	123357040	123357040	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:123357040C>T	uc003ego.2	-	29	5121	c.4839G>A	c.(4837-4839)GAG>GAA	p.E1613E	MYLK_uc010hrr.2_Silent_p.E48E|MYLK_uc011bjv.1_Silent_p.E413E|MYLK_uc011bjw.1_Silent_p.E1613E|MYLK_uc003egp.2_Silent_p.E1544E|MYLK_uc003egq.2_Silent_p.E1613E|MYLK_uc003egr.2_Silent_p.E1544E|MYLK_uc003egs.2_Silent_p.E1437E	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1613	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACCCCGCATTCTCTGAAACCA	0.552			NA											8	42					0	0	0.00308	0	0
TMCC1	23023	broad.mit.edu	37	3	129389241	129389241	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:129389241C>A	uc003emz.3	-	5	1944	c.1443G>T	c.(1441-1443)GAG>GAT	p.E481D	TMCC1_uc003emy.3_Missense_Mutation_p.E157D|TMCC1_uc011blc.1_Missense_Mutation_p.E302D|TMCC1_uc010htg.2_Missense_Mutation_p.E367D	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	481	Potential.					integral to membrane				skin(1)	1						CCTTGAGAGTCTCAAAGGATT	0.428			NA											44	63					2.47872e-24	3.21707e-24	0.010771	1	0
RAB6B	51560	broad.mit.edu	37	3	133557009	133557009	+	Splice_Site	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:133557009C>A	uc003epy.2	-	6	876	c.495_splice	c.e6+1	p.Q165_splice	RAB6B_uc011blu.1_Splice_Site_p.Q152_splice	NM_016577	NP_057661	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family						protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			pancreas(1)	1						TGTGTCCTCACCTGCTTCACG	0.488			NA											45	88					2.77807e-22	3.5718e-22	0.013114	1	0
ATR	545	broad.mit.edu	37	3	142274977	142274977	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:142274977T>C	uc003eux.3	-	10	2205	c.2083A>G	c.(2083-2085)AAA>GAA	p.K695E		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	695					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TCTTTGACTTTATCTCTGGGG	0.328			NA						Other_conserved_DNA_damage_response_genes					15	31					0	0	0.006122	0	0
ZIC1	7545	broad.mit.edu	37	3	147128441	147128441	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:147128441T>A	uc003ewe.2	+	1	1261	c.542T>A	c.(541-543)GTG>GAG	p.V181E		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	181					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TACGGCCAGGTGACCAGCCCG	0.687			NA											6	28					0	0	0.001984	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908564	164908564	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:164908564G>T	uc003fej.3	-	2	499	c.55C>A	c.(55-57)CTT>ATT	p.L19I	SLITRK3_uc003fek.2_Missense_Mutation_p.L19I	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	19						integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GTGCTTAGAAGAATTATCCAC	0.418			NA								HNSCC(40;0.11)			10	25					4.68919e-08	5.39699e-08	0.008291	1	0
ZBBX	79740	broad.mit.edu	37	3	167000157	167000157	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:167000157G>T	uc003fep.2	-	19	2329	c.2006C>A	c.(2005-2007)GCT>GAT	p.A669D	ZBBX_uc011bpc.1_Missense_Mutation_p.A708D|ZBBX_uc003feq.2_Missense_Mutation_p.A640D	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	669	Ser-rich.					intracellular	zinc ion binding			ovary(2)	2						TTCAGAAGCAGCTCTAGATGA	0.373			NA											16	67					6.31663e-08	7.25487e-08	0.003163	1	0
TTC14	151613	broad.mit.edu	37	3	180328193	180328193	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:180328193G>C	uc003fkk.2	+	12	2308	c.2176G>C	c.(2176-2178)GTT>CTT	p.V726L	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	726							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CAAAACAGAGGTTCCAGAAGA	0.343			NA											12	65					0	0	0.001368	0	0
DGKG	1608	broad.mit.edu	37	3	186015891	186015891	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:186015891G>A	uc003fqa.2	-	4	809	c.272C>T	c.(271-273)CCG>CTG	p.P91L	DGKG_uc003fqb.2_Missense_Mutation_p.P91L|DGKG_uc003fqc.2_Missense_Mutation_p.P91L|DGKG_uc011brx.1_Missense_Mutation_p.P91L	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	91					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TCCCTCCGTCGGGTGGTCAGA	0.612			NA											34	89					0	0	0.002836	0	0
TBCCD1	55171	broad.mit.edu	37	3	186274291	186274291	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:186274291G>C	uc003fqg.2	-	4	895	c.766C>G	c.(766-768)CTG>GTG	p.L256V	TBCCD1_uc011bry.1_Missense_Mutation_p.L256V|TBCCD1_uc003fqh.2_Missense_Mutation_p.L160V	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	256					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		CAGGTTTCCAGTTTGTAGAAA	0.443			NA											8	52					0	0	0.00308	0	0
KNG1	3827	broad.mit.edu	37	3	186450463	186450463	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:186450463G>A	uc011bsa.1	+	7	1142	c.930G>A	c.(928-930)CAG>CAA	p.Q310Q	KNG1_uc003fqr.2_Silent_p.Q310Q	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	310	Cystatin 3.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CAAGAGTACAGGTGTGTAAAC	0.388			NA											26	57					0	0	0.003954	0	0
KNG1	3827	broad.mit.edu	37	3	186459574	186459574	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:186459574T>C	uc011bsa.1	+	10	1601	c.1389T>C	c.(1387-1389)CAT>CAC	p.H463H	KNG1_uc003fqr.2_Intron	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	463	|His-rich.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GCCTTGGCCATGGACACGAAC	0.478			NA											8	20					0	0	0.006214	0	0
ZNF595	152687	broad.mit.edu	37	4	60018	60018	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:60018G>A	uc003fzv.1	+	3	354	c.198G>A	c.(196-198)AAG>AAA	p.K66K	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Silent_p.K66K|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_Intron|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	66					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		GCAATTTGAAGATACATGAGA	0.453			NA											7	132					0	0	0.008291	0	0
TMEM175	84286	broad.mit.edu	37	4	944993	944993	+	Splice_Site	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:944993A>T	uc003gbq.2	+	5	389	c.291_splice	c.e5-2	p.R97_splice	TMEM175_uc010ibl.1_Splice_Site_p.R97_splice|TMEM175_uc003gbp.1_Splice_Site_p.R15_splice|TMEM175_uc003gbr.2_Splice_Site_p.R15_splice|TMEM175_uc003gbu.2_Splice_Site_p.R15_splice|TMEM175_uc003gbs.2_Splice_Site|TMEM175_uc003gbt.2_Splice_Site|TMEM175_uc003gbv.2_Splice_Site|TMEM175_uc010ibm.2_5'Flank	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175							integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TAAATGGTTTAGGTTGTTCCA	0.403			NA											22	60					0	0	0.012319	0	0
TMEM175	84286	broad.mit.edu	37	4	952199	952199	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:952199G>A	uc003gbq.2	+	11	1528	c.1430G>A	c.(1429-1431)CGG>CAG	p.R477Q	TMEM175_uc003gbr.2_Missense_Mutation_p.R395Q|TMEM175_uc003gbu.2_Missense_Mutation_p.R395Q|TMEM175_uc003gbs.2_Missense_Mutation_p.R360Q|TMEM175_uc003gbt.2_Missense_Mutation_p.R360Q|TMEM175_uc003gbv.2_Missense_Mutation_p.R360Q|TMEM175_uc010ibm.2_Missense_Mutation_p.R293Q	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	477						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGGGTCCTGCGGGGCCTCGCC	0.726			NA											13	25					0	0	0.001368	0	0
KIAA1530	57654	broad.mit.edu	37	4	1343515	1343515	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:1343515C>T	uc003gde.3	+	3	749	c.302C>T	c.(301-303)CCC>CTC	p.P101L		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	101											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			CCTCTGCCGCCCCCCAGGGAG	0.637			NA											19	35					0	0	0.008871	0	0
NOP14	8602	broad.mit.edu	37	4	2945798	2945798	+	Splice_Site	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:2945798A>T	uc003ggj.1	-	13	1963	c.1891_splice	c.e13+1	p.G631_splice	C4orf10_uc003gge.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Splice_Site_p.G377_splice|NOP14_uc003ggk.3_Splice_Site_p.G631_splice|NOP14_uc003ggl.2_Splice_Site_p.G631_splice	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14						endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						AAATCAACTCACCTTGGCTTG	0.353			NA											15	29					0	0	0.00245	0	0
WDR1	9948	broad.mit.edu	37	4	10079485	10079485	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:10079485C>A	uc003gmf.2	-	13	1744	c.1461G>T	c.(1459-1461)GAG>GAT	p.E487D	WDR1_uc003gmg.2_Missense_Mutation_p.E347D|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	487	WD 9.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		GGCCCTTGGCCTCTAGGAGCT	0.647			NA											8	12					1.76689e-08	2.06828e-08	0.006214	1	0
SLIT2	9353	broad.mit.edu	37	4	20535276	20535276	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:20535276G>A	uc003gpr.1	+	18	1974	c.1770G>A	c.(1768-1770)ACG>ACA	p.T590T	SLIT2_uc003gps.1_Silent_p.T582T	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	590	LRR 14.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TACTTCTTACGAGTAATCGTT	0.348			NA											19	61					0	0	0.008871	0	0
RBPJ	3516	broad.mit.edu	37	4	26432131	26432131	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:26432131G>C	uc003grx.1	+	11	1410	c.1174G>C	c.(1174-1176)GAA>CAA	p.E392Q	RBPJ_uc003gry.1_Missense_Mutation_p.E377Q|RBPJ_uc003grz.1_Missense_Mutation_p.E392Q|RBPJ_uc003gsa.1_Missense_Mutation_p.E378Q|RBPJ_uc003gsb.1_Missense_Mutation_p.E379Q|RBPJ_uc003gsc.1_Intron|uc003gsd.2_5'Flank	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	392	IPT/TIG.				DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				TGTAGAAGCTGAAACTATGTA	0.428			NA											7	49					0	0	0.004482	0	0
CCKAR	886	broad.mit.edu	37	4	26490979	26490979	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:26490979G>A	uc003gse.1	-	2	393	c.240C>T	c.(238-240)CTC>CTT	p.L80L		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	80	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	CCAGGGAGAGGAGGAAGATGT	0.547			NA											11	48					0	0	0.008291	0	0
KLHL5	51088	broad.mit.edu	37	4	39105076	39105076	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:39105076C>T	uc003gts.2	+	7	1683	c.1608C>T	c.(1606-1608)CCC>CCT	p.P536P	KLHL5_uc003gtp.2_Silent_p.P490P|KLHL5_uc003gtq.2_Silent_p.P349P|KLHL5_uc003gtr.1_Silent_p.P536P|KLHL5_uc003gtt.2_Silent_p.P475P	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	536	Kelch 2.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1						GCTACAACCCCAAAACAAAAA	0.443			NA											13	93					0	0	0.004007	0	0
UGDH	7358	broad.mit.edu	37	4	39512080	39512080	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:39512080G>C	uc003guk.1	-	5	872	c.556C>G	c.(556-558)CCA>GCA	p.P186A	UGDH_uc011byp.1_Missense_Mutation_p.P89A|UGDH_uc003gul.1_Missense_Mutation_p.P119A	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	186					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TGGCCCTCTGGAGTTTCATCC	0.517			NA											13	95					0	0	0.001855	0	0
GABRA4	2557	broad.mit.edu	37	4	46967176	46967176	+	Silent	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:46967176A>G	uc003gxg.2	-	8	1084	c.945T>C	c.(943-945)TAT>TAC	p.Y315Y		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	315					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGGCGGTAGCATAGGACACTT	0.438	Ovarian(6;283 369 8234 12290 33402)		NA											26	61					0	0	0.003954	0	0
GABRB1	2560	broad.mit.edu	37	4	47033973	47033973	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:47033973G>T	uc003gxh.2	+	2	497	c.123G>T	c.(121-123)GTG>GTT	p.V41V	GABRB1_uc011bze.1_5'UTR|GABRB1_uc011bzd.1_Silent_p.V41V|GABRB1_uc010igg.2_RNA	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	41	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAGAGACAGTGGACAGATTGC	0.448			NA											56	166					9.53978e-28	1.25295e-27	0.00361	1	0
FRYL	285527	broad.mit.edu	37	4	48542798	48542798	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:48542798C>G	uc003gyh.1	-	46	6472	c.5867G>C	c.(5866-5868)CGG>CCG	p.R1956P	FRYL_uc003gyg.1_Missense_Mutation_p.R652P|FRYL_uc003gyi.1_Missense_Mutation_p.R844P|FRYL_uc003gyj.1_Missense_Mutation_p.R251P	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1956					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TGTGTTACTCCGCCGCCGGTC	0.418			NA											18	38					0	0	0.007413	0	0
UGT2B11	10720	broad.mit.edu	37	4	70074182	70074182	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:70074182G>C	uc003heh.2	-	3	898	c.889C>G	c.(889-891)CAG>GAG	p.Q297E	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	297					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						CCAGAGCTCTGTACAAACTCC	0.403			NA											29	142					0	0	0.002836	0	0
NKX6-1	4825	broad.mit.edu	37	4	85419026	85419026	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:85419026G>C	uc003hpa.1	-	1	362	c.356C>G	c.(355-357)TCG>TGG	p.S119W		NM_006168	NP_006159	P78426	NKX61_HUMAN	NK6 transcription factor related, locus 1	119	Poly-Ser.|Repressor domain (By similarity).				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus					0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		accggagggcgaggcggaggG	0.358			NA											3	10					0	0	0.004672	0	0
WDFY3	23001	broad.mit.edu	37	4	85687123	85687123	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:85687123C>T	uc003hpd.2	-	32	5436	c.5028G>A	c.(5026-5028)GAG>GAA	p.E1676E		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1676						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GTAAGTGTTCCTCCATAAACA	0.368			NA											28	39					0	0	0.010818	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170789	90170789	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:90170789G>A	uc003hsm.1	-	2	992	c.473C>T	c.(472-474)TCA>TTA	p.S158L		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	158										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGTTCTCTGTGATCTCATCAG	0.517			NA											23	106					0	0	0.00278	0	0
ATOH1	474	broad.mit.edu	37	4	94750827	94750827	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:94750827C>A	uc003hta.1	+	1	750	c.750C>A	c.(748-750)AAC>AAA	p.N250K		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	250					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		GCGCGGGCAACGCGACCGCAG	0.726			NA											15	12					0.000219431	0.000235749	0.00245	1	0
DKK2	27123	broad.mit.edu	37	4	107845337	107845337	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:107845337C>A	uc003hyi.2	-	4	1259	c.554G>T	c.(553-555)CGA>CTA	p.R185L	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	185	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GTCTGATGATCGTAGGCAGGG	0.453			NA											19	31					5.35267e-07	6.10938e-07	0.007413	1	0
C4orf21	55345	broad.mit.edu	37	4	113475105	113475105	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:113475105C>A	uc003iau.2	-	22	5443	c.5232G>T	c.(5230-5232)CAG>CAT	p.Q1744H	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.Q202H	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	566						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTTCTTTTAACTGTTCACTTT	0.348			NA											14	52					1.99824e-07	2.28548e-07	0.00499	1	0
C4orf21	55345	broad.mit.edu	37	4	113540608	113540608	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:113540608G>A	uc003iau.2	-	6	801	c.590C>T	c.(589-591)TCT>TTT	p.S197F	C4orf21_uc003iaw.2_Missense_Mutation_p.S197F	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GAAGGATGGAGAAAAAACCGA	0.383			NA											7	16					0	0	0.001984	0	0
NDST4	64579	broad.mit.edu	37	4	115858642	115858642	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:115858642G>C	uc003ibu.2	-	5	1918	c.1239C>G	c.(1237-1239)ATC>ATG	p.I413M	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	413	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AGCCCATGTTGATTGGTATTC	0.408			NA											4	29					0	0	0.009096	0	0
SYNPO2	171024	broad.mit.edu	37	4	119944633	119944633	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:119944633G>A	uc003icm.3	+	2	350	c.154G>A	c.(154-156)GAA>AAA	p.E52K	SYNPO2_uc010ina.2_Missense_Mutation_p.E52K|SYNPO2_uc010inb.2_Missense_Mutation_p.E52K|SYNPO2_uc011cgh.1_Missense_Mutation_p.E52K|SYNPO2_uc010inc.2_5'UTR	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	52	PDZ.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TGAGGGAGATGAAGTGGTTTC	0.423			NA											9	21					0	0	0.004482	0	0
ANKRD50	57182	broad.mit.edu	37	4	125591188	125591188	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:125591188T>C	uc003ifg.3	-	3	3510	c.3244A>G	c.(3244-3246)ATG>GTG	p.M1082V	ANKRD50_uc011cgo.1_Missense_Mutation_p.M903V|ANKRD50_uc010inw.2_Missense_Mutation_p.M1082V	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1082	ANK 19.									central_nervous_system(1)	1						GCAACACGCATAGCAGTGCGT	0.423			NA											11	44					0	0	0.008291	0	0
FAT4	79633	broad.mit.edu	37	4	126242530	126242530	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:126242530G>T	uc003ifj.3	+	1	4964	c.4964G>T	c.(4963-4965)AGC>ATC	p.S1655I		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1655	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GAAGCAGCTAGCCCCAGAGGA	0.428			NA											7	57					8.12818e-05	8.76694e-05	0.001984	1	0
SLC25A31	83447	broad.mit.edu	37	4	128651878	128651878	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:128651878G>A	uc003ifl.2	+	1	324	c.178G>A	c.(178-180)GAG>AAG	p.E60K		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	60	Solcar 1.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						GATCAGCCCCGAGGCGCGGTA	0.697			NA											6	31					0	0	0.001984	0	0
GAB1	2549	broad.mit.edu	37	4	144359702	144359702	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:144359702C>T	uc003ije.2	+	4	1503	c.1144C>T	c.(1144-1146)CCT>TCT	p.P382S	GAB1_uc003ijd.2_Missense_Mutation_p.P382S|GAB1_uc011chq.1_Missense_Mutation_p.P279S	NM_002039	NP_002030	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1 isoform b	382					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)					AGGGATGTCGCCTTCACGTAG	0.443			NA											11	51					0	0	0.008291	0	0
NR3C2	4306	broad.mit.edu	37	4	149002645	149002645	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:149002645C>T	uc003ilj.3	-	9	3139	c.2805G>A	c.(2803-2805)GTG>GTA	p.V935V	NR3C2_uc003ilk.3_Silent_p.V818V|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	935	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GCAGGTCGCTCACCAGCTGTA	0.567	Melanoma(27;428 957 40335 51025 51111)		NA											5	20					0	0	0.001168	0	0
FGA	2243	broad.mit.edu	37	4	155507040	155507040	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:155507040G>T	uc003iod.1	-	5	1599	c.1541C>A	c.(1540-1542)CCT>CAT	p.P514H	FGA_uc003ioe.1_Missense_Mutation_p.P514H|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	514	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGCTTCATCAGGGTGCCTATG	0.502	NSCLC(143;340 1922 20892 22370 48145)		NA											22	61					2.21704e-12	2.69281e-12	0.00278	1	0
GUCY1A3	2982	broad.mit.edu	37	4	156638369	156638369	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:156638369C>A	uc003iov.2	+	9	2167	c.1631C>A	c.(1630-1632)ACT>AAT	p.T544N	GUCY1A3_uc010iqc.2_Missense_Mutation_p.T544N|GUCY1A3_uc003iow.2_Missense_Mutation_p.T544N|GUCY1A3_uc010iqd.2_Missense_Mutation_p.T543N|GUCY1A3_uc003iox.2_Missense_Mutation_p.T544N|GUCY1A3_uc003ioz.2_Missense_Mutation_p.T309N|GUCY1A3_uc003ioy.2_Missense_Mutation_p.T544N|GUCY1A3_uc010iqe.2_Missense_Mutation_p.T309N|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.T544N	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	544	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GAGAGTGATACTCATGCTGTT	0.433			NA											12	33					6.40141e-05	6.93171e-05	0.010729	1	0
RXFP1	59350	broad.mit.edu	37	4	159568066	159568066	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:159568066C>G	uc003ipz.2	+	16	1551	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	RXFP1_uc011cja.1_Missense_Mutation_p.S385C|RXFP1_uc010iqo.2_Missense_Mutation_p.S442C|RXFP1_uc011cjb.1_Missense_Mutation_p.S388C|RXFP1_uc010iqk.2_Missense_Mutation_p.S358C|RXFP1_uc011cjc.1_Missense_Mutation_p.S409C|RXFP1_uc011cjd.1_Missense_Mutation_p.S409C|RXFP1_uc010iql.2_Missense_Mutation_p.S334C|RXFP1_uc011cje.1_Missense_Mutation_p.S517C|RXFP1_uc010iqm.2_Missense_Mutation_p.S457C|RXFP1_uc011cjf.1_Missense_Mutation_p.S359C|RXFP1_uc010iqn.2_Missense_Mutation_p.S435C	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	490	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CTTGTAGGATCTTTGGCCATT	0.398			NA											8	28					0	0	0.00308	0	0
NAF1	92345	broad.mit.edu	37	4	164050300	164050300	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:164050300G>A	uc003iqj.2	-	8	1428	c.1234C>T	c.(1234-1236)CAG>TAG	p.Q412*	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	412					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				TTTTGTCTCTGAGAAGGAAAT	0.413			NA											9	25					0	0	0.004482	0	0
DDX60L	91351	broad.mit.edu	37	4	169362539	169362539	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:169362539G>C	uc003irq.3	-	10	1464	c.1243C>G	c.(1243-1245)CTG>GTG	p.L415V	DDX60L_uc003irr.1_Missense_Mutation_p.L415V|DDX60L_uc003irs.1_Missense_Mutation_p.L142V	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	415							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GTTGTTCTCAGAGGAAAAGAC	0.368			NA											22	48					0	0	0.012319	0	0
PDLIM3	27295	broad.mit.edu	37	4	186425632	186425632	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:186425632A>G	uc003ixw.3	-	7	1026	c.902T>C	c.(901-903)ATA>ACA	p.I301T	PDLIM3_uc003ixx.3_Missense_Mutation_p.I253T|PDLIM3_uc010isi.2_RNA	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	301	LIM zinc-binding.					sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		AACTTACACTATGCCACTCCC	0.493			NA											9	28					0	0	0.006214	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5146374	5146374	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:5146374G>A	uc003jdl.2	+	3	445	c.307G>A	c.(307-309)GGC>AGC	p.G103S	ADAMTS16_uc003jdk.1_Missense_Mutation_p.G103S|ADAMTS16_uc003jdj.1_Missense_Mutation_p.G103S	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	103					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCGGCTGAAAGGCTCCAGGCA	0.557			NA											15	36					0	0	0.00278	0	0
ADCY2	108	broad.mit.edu	37	5	7804778	7804778	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:7804778C>G	uc003jdz.1	+	22	2923	c.2856C>G	c.(2854-2856)AGC>AGG	p.S952R	ADCY2_uc011cmo.1_Missense_Mutation_p.S772R|ADCY2_uc010itm.1_Missense_Mutation_p.S148R	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	952	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CAGGTCTGAGCGCTGTGCCCA	0.527			NA											8	46					0	0	0.00308	0	0
MTRR	4552	broad.mit.edu	37	5	7870910	7870910	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:7870910G>T	uc003jed.2	+	2	114	c.84G>T	c.(82-84)ATG>ATT	p.M28I	FASTKD3_uc011cmp.1_5'Flank|FASTKD3_uc003jeb.2_5'Flank|FASTKD3_uc003jec.2_5'Flank|MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.M1I|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	28					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TTGAAGTGATGAGGAGGTTTC	0.403			NA											19	24					3.99206e-14	4.91399e-14	0.007413	1	0
CDH18	1016	broad.mit.edu	37	5	19473630	19473630	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:19473630G>T	uc003jgc.2	-	12	2455	c.2078C>A	c.(2077-2079)CCT>CAT	p.P693H	CDH18_uc003jgd.2_Missense_Mutation_p.P693H|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	693	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTTCACTTCAGGTCTGATATC	0.502			NA											16	69					1.3612e-06	1.53135e-06	0.003163	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33527457	33527457	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:33527457T>G	uc003jia.1	-	24	4784	c.4621A>C	c.(4621-4623)AAG>CAG	p.K1541Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.K1456Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1541	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGTTTGTCCTTAGTGCAAAGT	0.423			NA								HNSCC(64;0.19)			13	42					0	0	0.001368	0	0
IL7R	3575	broad.mit.edu	37	5	35867450	35867450	+	Silent	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:35867450A>G	uc003jjs.2	+	3	353	c.264A>G	c.(262-264)CTA>CTG	p.L88L	IL7R_uc011coo.1_Silent_p.L88L|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	88	Extracellular (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TCAGGAAACTACAAGAGATAT	0.398			NA											7	34					0	0	0.001984	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41004621	41004621	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:41004621G>A	uc003jmj.3	-	37	4511	c.4021C>T	c.(4021-4023)CAT>TAT	p.H1341Y	HEATR7B2_uc003jmi.3_Missense_Mutation_p.H896Y	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1341							binding			ovary(6)|central_nervous_system(2)	8						AACTGCTTATGTTTCTTCACC	0.393			NA											10	22					0	0	0.006214	0	0
OXCT1	5019	broad.mit.edu	37	5	41870434	41870434	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:41870434G>A	uc003jmn.2	-	1	358	c.27C>T	c.(25-27)TCC>TCT	p.S9S		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	9					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	GCCGAAGCCCGGAGGAGAGGA	0.652			NA											6	24					0	0	0.001984	0	0
PDE8B	8622	broad.mit.edu	37	5	76649204	76649204	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:76649204G>T	uc003kfa.2	+	10	1185	c.1140G>T	c.(1138-1140)CTG>CTT	p.L380L	PDE8B_uc003kfb.2_Silent_p.L360L|PDE8B_uc003kfc.2_Silent_p.L380L|PDE8B_uc003kfd.2_Silent_p.L333L|PDE8B_uc003kfe.2_Intron	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	380					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TCAAGAAACTGTGTTGTACCA	0.373			NA											18	15					1.96895e-08	2.2999e-08	0.00278	1	0
GPR98	84059	broad.mit.edu	37	5	90106906	90106906	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:90106906C>T	uc003kju.2	+	74	15925	c.15829C>T	c.(15829-15831)CGT>TGT	p.R5277C	GPR98_uc003kjt.2_Missense_Mutation_p.R2983C|GPR98_uc003kjw.2_Missense_Mutation_p.R938C	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5277	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATTGCCCTTTCGTGGTATCTA	0.413			NA											20	29					0	0	0.007413	0	0
FAM170A	340069	broad.mit.edu	37	5	118969672	118969672	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:118969672C>T	uc003ksm.2	+	3	439	c.229C>T	c.(229-231)CGA>TGA	p.R77*	FAM170A_uc003ksl.2_Nonsense_Mutation_p.R77*|FAM170A_uc003ksn.2_Nonsense_Mutation_p.R77*|FAM170A_uc003kso.2_Nonsense_Mutation_p.R30*	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	77						intracellular	zinc ion binding			skin(1)	1						GAGAATACATCGAGACAGCCC	0.512			NA											10	42					0	0	0.010729	0	0
FBN2	2201	broad.mit.edu	37	5	127714528	127714528	+	Silent	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:127714528A>G	uc003kuu.2	-	12	2098	c.1659T>C	c.(1657-1659)CCT>CCC	p.P553P	FBN2_uc003kuv.2_Silent_p.P520P	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	553	EGF-like 7; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AATAGGAACCAGGTGTGTTAA	0.398			NA											32	28					0	0	0.010818	0	0
RAD50	10111	broad.mit.edu	37	5	131973867	131973867	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:131973867G>A	uc003kxi.2	+	23	3957	c.3570G>A	c.(3568-3570)AAG>AAA	p.K1190K	RAD50_uc003kxh.2_Silent_p.K1051K	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1190					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGATGCTGAAGGGAGACACAG	0.453			NA						Homologous_recombination					7	13					0	0	0.00308	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188961	140188961	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:140188961G>C	uc003lhi.2	+	1	2290	c.2189G>C	c.(2188-2190)GGC>GCC	p.G730A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.G730A|PCDHA4_uc011daa.1_Missense_Mutation_p.G730A	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	730	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCACCGAGGGCGCGTGCGCT	0.662			NA											26	35					0	0	0.004656	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230279	140230279	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:140230279G>A	uc003lhu.2	+	1	2923	c.2199G>A	c.(2197-2199)GCG>GCA	p.A733A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.A733A	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	733	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGTGCGCGCCTGGCAAGC	0.637	Melanoma(55;1800 1972 14909)		NA											37	35					0	0	0.004878	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554444	140554444	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:140554444G>T	uc003lit.2	+	1	2202	c.2028G>T	c.(2026-2028)GCG>GCT	p.A676A	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	676	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCGGAGGCGGCCCCGGACC	0.692			NA											40	99					2.00842e-17	2.5406e-17	0.010771	1	0
PCDHB9	56127	broad.mit.edu	37	5	140568964	140568964	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:140568964G>T	uc003liw.1	+	3	2073	c.2073G>T	c.(2071-2073)GTG>GTT	p.V691V	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	691	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTACCTGGTGGTGGCGTTGG	0.701			NA											72	121					4.41824e-40	5.98917e-40	0.00361	1	0
PCDHB14	56122	broad.mit.edu	37	5	140604476	140604476	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:140604476G>A	uc003ljb.2	+	1	1399	c.1399G>A	c.(1399-1401)GCC>ACC	p.A467T	PCDHB14_uc011dal.1_Missense_Mutation_p.A314T	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	467	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAACAGCCCCGCCCTGCACAT	0.627	Ovarian(141;50 1831 27899 33809 37648)		NA											93	126					0	0	0.00361	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773984	140773985	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:140773984_140773985GC>TT	uc003lkd.1	+	1	2502_2503	c.1604_1605GC>TT	c.(1603-1605)AGC>ATT	p.S535I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.S535I	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	535	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAACAGCCAGCGACAGCGGGG	0.584			NA											21	91					0	0	0.004672	0	0
JAKMIP2	9832	broad.mit.edu	37	5	146997527	146997527	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:146997527A>T	uc003loq.1	-	19	2675	c.2293T>A	c.(2293-2295)TAT>AAT	p.Y765N	JAKMIP2_uc011dbx.1_Missense_Mutation_p.Y723N|JAKMIP2_uc003lor.1_Missense_Mutation_p.Y744N|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Missense_Mutation_p.Y765N	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	765	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACAGTCATACTCTCTGCTC	0.463			NA											14	39					0	0	0.001855	0	0
CPEB4	80315	broad.mit.edu	37	5	173359497	173359497	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:173359497A>G	uc003mcs.3	+	3	2658	c.1252A>G	c.(1252-1254)ATT>GTT	p.I418V	CPEB4_uc010jju.1_Intron|CPEB4_uc010jjv.2_Intron|CPEB4_uc011dfg.1_Intron|CPEB4_uc003mct.3_Missense_Mutation_p.I36V|CPEB4_uc003mcu.3_Intron	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	418							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CTCTCTGCTTATTAATGGTAA	0.358			NA											21	16					0	0	0.00333	0	0
MGAT4B	11282	broad.mit.edu	37	5	179225515	179225515	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:179225515C>T	uc003mks.2	-	12	1789	c.1420G>A	c.(1420-1422)GAC>AAC	p.D474N	MGAT4B_uc003mkp.2_Missense_Mutation_p.D328N|MGAT4B_uc003mkq.2_Missense_Mutation_p.R249Q|MGAT4B_uc003mkr.2_Missense_Mutation_p.D489N|MIR1229_hsa-mir-1229|MI0006319_5'Flank	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	474	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAACTTACGTCGAAGGGCAGC	0.607	GBM(13;414 434 4098 22176 23230)		NA											6	26					0	0	0.001984	0	0
HUS1B	135458	broad.mit.edu	37	6	656914	656914	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:656914C>T	uc003mtg.2	-	1	51	c.31G>A	c.(31-33)GGC>AGC	p.G11S	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	11											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		TCTAGACAGCCTTTGCCGGTG	0.652			NA											14	39					0	0	0.003163	0	0
RREB1	6239	broad.mit.edu	37	6	7229349	7229349	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:7229349G>A	uc003mxc.2	+	10	1407	c.1017G>A	c.(1015-1017)GTG>GTA	p.V339V	RREB1_uc003mxb.2_Silent_p.V339V|RREB1_uc010jnx.2_Silent_p.V339V	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	339					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				AGACCCATGTGGCGGCAGACC	0.627			NA											6	29					0	0	0.001984	0	0
DSP	1832	broad.mit.edu	37	6	7580467	7580467	+	Silent	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:7580467G>C	uc003mxp.1	+	23	4323	c.4044G>C	c.(4042-4044)CTG>CTC	p.L1348L	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1348	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAATGAACTGAGTAAGGTAA	0.443			NA											6	39					0	0	0.001168	0	0
DSP	1832	broad.mit.edu	37	6	7581116	7581116	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:7581116G>C	uc003mxp.1	+	23	4972	c.4693G>C	c.(4693-4695)GAG>CAG	p.E1565Q	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1565	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTCTCTGAAAGAGCTGCAGCT	0.542			NA											16	44					0	0	0.004007	0	0
JARID2	3720	broad.mit.edu	37	6	15496899	15496899	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:15496899G>A	uc003nbj.2	+	7	1687	c.1443G>A	c.(1441-1443)CTG>CTA	p.L481L	JARID2_uc011diu.1_Silent_p.L345L|JARID2_uc011div.1_Silent_p.L309L|JARID2_uc011diw.1_Silent_p.L443L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	481					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GAGGTCTGCTGAACGGACACG	0.672			NA											6	25					0	0	0.001984	0	0
HIST1H1D	3007	broad.mit.edu	37	6	26234874	26234874	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:26234874C>G	uc003nhd.2	-	1	343	c.288G>C	c.(286-288)CAG>CAC	p.Q96H		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	96	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TACCTTTGGTCTGCACCAGAG	0.527			NA											21	109					0	0	0.012319	0	0
BTN3A3	10384	broad.mit.edu	37	6	26452130	26452130	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:26452130G>A	uc003nhz.2	+	11	1426	c.1246G>A	c.(1246-1248)GTG>ATG	p.V416M	BTN3A3_uc003nia.2_Missense_Mutation_p.V374M|BTN3A3_uc011dkn.1_Missense_Mutation_p.V367M	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	416	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						TAGTAAGAACGTGGAGAGGAA	0.498			NA											8	48					0	0	0.00308	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833191	27833191	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:27833191C>G	uc003njw.2	+	1	85	c.59C>G	c.(58-60)TCT>TGT	p.S20C		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	20					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						ACCCGCTCTTCTCGTGCCGGT	0.647			NA											27	82					0	0	0.007291	0	0
BAT2	7916	broad.mit.edu	37	6	31597526	31597526	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:31597526G>A	uc003nvb.3	+	14	2407	c.2158G>A	c.(2158-2160)GAT>AAT	p.D720N	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.D720N	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	720	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						AATGAACTTTGATCCCCGATG	0.647			NA											18	35					0	0	0.008871	0	0
C6orf27	80737	broad.mit.edu	37	6	31737788	31737788	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:31737788G>C	uc011dog.1	-	8	1428	c.1190C>G	c.(1189-1191)TCA>TGA	p.S397*	C6orf27_uc003nxd.2_Nonsense_Mutation_p.S72*|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	397						extracellular region				ovary(3)	3						CTGCAGGGCTGACAGGCACAT	0.612			NA											3	32					0	0	0.004672	0	0
NOTCH4	4855	broad.mit.edu	37	6	32163228	32163228	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:32163228C>T	uc003obb.2	-	30	6137	c.5998G>A	c.(5998-6000)GAG>AAG	p.E2000K	GPSM3_uc003oax.3_5'Flank|GPSM3_uc003oay.3_5'Flank|GPSM3_uc003oaz.2_5'UTR|NOTCH4_uc011dpt.1_3'UTR|NOTCH4_uc003oba.2_Missense_Mutation_p.E660K|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	2000	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TTTTTACCCTCTCCTCCTTGG	0.507			NA											11	54					0	0	0.008291	0	0
C6orf10	10665	broad.mit.edu	37	6	32260881	32260881	+	Silent	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:32260881A>T	uc011dpy.1	-	12	1742	c.1569T>A	c.(1567-1569)GGT>GGA	p.G523G	C6orf10_uc011dpx.1_Intron	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	523	Lys-rich.					integral to membrane				skin(1)	1						ttcctttgtcaccttttgtgt	0.154			NA											17	37					0	0	0.004007	0	0
TAP2	6891	broad.mit.edu	37	6	32802973	32802973	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:32802973G>A	uc003occ.2	-	4	934	c.903C>T	c.(901-903)CCC>CCT	p.P301P	TAP2_uc011dqf.1_Silent_p.P301P|TAP2_uc003ocb.1_Silent_p.P301P|TAP2_uc003ocd.2_Silent_p.P301P	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	301	Involved in peptide-binding site.|Helical; Name=7; (Potential).|ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CTATTGTGAAGGGCATGTGCA	0.542			NA											10	41					0	0	0.006214	0	0
ANKS1A	23294	broad.mit.edu	37	6	35053622	35053622	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:35053622C>T	uc003ojx.3	+	22	3354	c.3212C>T	c.(3211-3213)TCC>TTC	p.S1071F	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Missense_Mutation_p.S612F|ANKS1A_uc010jvp.1_Missense_Mutation_p.S445F	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	1071	PID.					cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						GCCCAGAAGTCCAGGGCGACG	0.592			NA											6	37					0	0	0.001168	0	0
RSPH9	221421	broad.mit.edu	37	6	43638551	43638551	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:43638551G>A	uc003ovw.1	+	5	722	c.696G>A	c.(694-696)AGG>AGA	p.R232R	RSPH9_uc003ovx.1_Missense_Mutation_p.G250R	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	232					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				upper_aerodigestive_tract(1)|skin(1)	2						AGATGGAGAGGGGCAATGCCC	0.632			NA							Kartagener_syndrome				5	69					0	0	0.000602	0	0
GCM1	8521	broad.mit.edu	37	6	52993489	52993489	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:52993489T>C	uc003pbp.2	-	6	1035	c.826A>G	c.(826-828)AGT>GGT	p.S276G		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	276						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					AGGTCTCCACTACTGTAGGTT	0.498			NA											11	38					0	0	0.001855	0	0
FAM83B	222584	broad.mit.edu	37	6	54806260	54806260	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:54806260A>G	uc003pck.2	+	5	2607	c.2491A>G	c.(2491-2493)AAG>GAG	p.K831E		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	831										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TCCTAGAAGAAAGCATTCTTC	0.378			NA											9	26					0	0	0.004482	0	0
LGSN	51557	broad.mit.edu	37	6	63989943	63989943	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:63989943A>T	uc003peh.2	-	4	1547	c.1513T>A	c.(1513-1515)TTA>ATA	p.L505I	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	505					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	AAATACTCTAAGAATTTATTT	0.323			NA											60	47					0	0	0.00361	0	0
RIMS1	22999	broad.mit.edu	37	6	72889469	72889469	+	Silent	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:72889469C>A	uc003pga.2	+	5	740	c.663C>A	c.(661-663)CCC>CCA	p.P221P	RIMS1_uc011dyb.1_5'Flank|RIMS1_uc003pgc.2_5'Flank|RIMS1_uc003pgb.3_5'Flank	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	221					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CTCAGACACCCCTAAGCACAG	0.602			NA											25	67					1.17739e-12	1.43324e-12	0.005443	1	0
MDN1	23195	broad.mit.edu	37	6	90402199	90402199	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:90402199T>A	uc003pnn.1	-	63	10666	c.10550A>T	c.(10549-10551)GAC>GTC	p.D3517V		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3517					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGCCCTCTGGTCCAACTCTCC	0.602			NA											13	24					0	0	0.00245	0	0
MDN1	23195	broad.mit.edu	37	6	90421912	90421912	+	Silent	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:90421912C>G	uc003pnn.1	-	49	7610	c.7494G>C	c.(7492-7494)CTG>CTC	p.L2498L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2498					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CATTGAATTTCAGGTTCTCAG	0.398			NA											50	74					0	0	0.00361	0	0
FUT9	10690	broad.mit.edu	37	6	96651885	96651885	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:96651885C>A	uc003pop.3	+	3	1195	c.854C>A	c.(853-855)TCA>TAA	p.S285*		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	285	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CCAGCAGATTCATTCATTCAT	0.383	Melanoma(98;1369 1476 6592 22940 26587)		NA											15	26					7.93312e-07	8.97997e-07	0.00245	1	0
KLHL32	114792	broad.mit.edu	37	6	97562061	97562061	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:97562061A>G	uc010kcm.1	+	7	1502	c.1030A>G	c.(1030-1032)ATG>GTG	p.M344V	KLHL32_uc003poy.2_Missense_Mutation_p.M344V|KLHL32_uc011ead.1_Missense_Mutation_p.M308V|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Missense_Mutation_p.M275V|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	344	Kelch 1.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TGTGGCAGTCATGGGGGACTT	0.572			NA											6	68					0	0	0.001168	0	0
KIAA1919	91749	broad.mit.edu	37	6	111583529	111583529	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:111583529A>G	uc003puv.3	+	2	519	c.97A>G	c.(97-99)AGT>GGT	p.S33G		NM_153369	NP_699200	Q5TF39	NAGT1_HUMAN	sodium-dependent glucose transporter 1	33	Extracellular (Potential).				carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		AAATATCAGTAGTCTGTCTTT	0.373			NA											56	79					0	0	0.00361	0	0
REV3L	5980	broad.mit.edu	37	6	111650886	111650886	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:111650886C>G	uc003puy.3	-	25	8413	c.8090G>C	c.(8089-8091)AGA>ACA	p.R2697T	REV3L_uc003pux.3_Missense_Mutation_p.R2619T|REV3L_uc003puz.3_Missense_Mutation_p.R2619T|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2697					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CACCATAAATCTAGTCTTCAA	0.383			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					12	33					0	0	0.010729	0	0
THEMIS	387357	broad.mit.edu	37	6	128134390	128134390	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:128134390G>T	uc003qbi.2	-	5	1715	c.1396C>A	c.(1396-1398)CTT>ATT	p.L466I	THEMIS_uc010kfa.2_Missense_Mutation_p.L369I|THEMIS_uc011ebt.1_Missense_Mutation_p.L466I|THEMIS_uc010kfb.2_Missense_Mutation_p.L431I	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	466	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TCAATGGAAAGATCCCTGACA	0.468			NA											15	59					2.62699e-14	3.24094e-14	0.003163	1	0
OR2A4	79541	broad.mit.edu	37	6	132021854	132021854	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:132021854T>C	uc011ecd.1	-	1	688	c.688A>G	c.(688-690)AGG>GGG	p.R230G	ENPP3_uc003qcu.3_Intron|ENPP3_uc010kfq.2_Intron|ENPP3_uc003qcv.2_Intron	NM_030908	NP_112170	O95047	OR2A4_HUMAN	olfactory receptor, family 2, subfamily A,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.018)|OV - Ovarian serous cystadenocarcinoma(155;0.041)		TGAACTTCCCTTGATTGGATC	0.488			NA											10	81					0	0	0.00245	0	0
SHPRH	257218	broad.mit.edu	37	6	146264414	146264414	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:146264414A>T	uc003qlf.2	-	9	2502	c.2103T>A	c.(2101-2103)TTT>TTA	p.F701L	SHPRH_uc003qld.2_Missense_Mutation_p.F701L|SHPRH_uc003qle.2_Missense_Mutation_p.F701L|SHPRH_uc003qlg.1_Missense_Mutation_p.F257L|SHPRH_uc003qlj.1_Missense_Mutation_p.F590L	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	701	PHD-type.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GGGGGCAGTAAAAAGGCTTGA	0.453			NA											15	24					0	0	0.00245	0	0
SHPRH	257218	broad.mit.edu	37	6	146268732	146268732	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:146268732A>C	uc003qlf.2	-	6	1508	c.1109T>G	c.(1108-1110)ATT>AGT	p.I370S	SHPRH_uc003qld.2_Missense_Mutation_p.I370S|SHPRH_uc003qle.2_Missense_Mutation_p.I370S|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.I259S|SHPRH_uc003qlk.1_Missense_Mutation_p.I370S	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	370	Helicase ATP-binding; first part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		ATCTGCTAAAATTCCACCAAG	0.423			NA											13	62					0	0	0.001368	0	0
SYNE1	23345	broad.mit.edu	37	6	152605206	152605206	+	Silent	SNP	C	C	A	rs149923357	byFrequency	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:152605206C>A	uc010kiw.2	-	96	18716	c.18114G>T	c.(18112-18114)GCG>GCT	p.A6038A	SYNE1_uc010kiv.2_Silent_p.A562A|SYNE1_uc003qos.3_Silent_p.A562A|SYNE1_uc003qot.3_Silent_p.A5967A|SYNE1_uc003qou.3_Silent_p.A6038A|SYNE1_uc010kiy.1_Silent_p.A217A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6038	Spectrin 20.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCAGCTGCTCCGCAGGGTCGG	0.552			NA								HNSCC(10;0.0054)			38	31					3.61848e-18	4.59848e-18	0.007835	1	0
FBXO5	26271	broad.mit.edu	37	6	153296193	153296193	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:153296193T>G	uc003qpg.2	-	2	776	c.667A>C	c.(667-669)ATT>CTT	p.I223L	FBXO5_uc003qph.2_Missense_Mutation_p.I177L	NM_012177	NP_036309	Q9UKT4	FBX5_HUMAN	F-box only protein 5 isoform a	223	Interaction with EVI5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding				0		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		CTGGCTATAATTTCCTTCAGC	0.373	NSCLC(121;372 1757 17721 17977 29669)		NA											30	37					0	0	0.009535	0	0
EZR	7430	broad.mit.edu	37	6	159188057	159188057	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:159188057A>T	uc003qrt.3	-	13	1865	c.1650T>A	c.(1648-1650)AAT>AAA	p.N550K	EZR_uc011efr.1_Missense_Mutation_p.N157K|EZR_uc011efs.1_Missense_Mutation_p.N518K|EZR_uc003qru.3_Missense_Mutation_p.N550K	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	550	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GGATGATGTCATTGTGGGTCC	0.562			NA											73	98					0	0	0.00361	0	0
C6orf118	168090	broad.mit.edu	37	6	165713854	165713854	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:165713854T>A	uc003qum.3	-	3	911	c.875A>T	c.(874-876)AAG>ATG	p.K292M	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	292											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		GTTTCTTACCTTAACTTTTTT	0.303			NA											10	87					0	0	0.010729	0	0
RBAK	57786	broad.mit.edu	37	7	5104216	5104216	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:5104216G>A	uc010kss.1	+	6	1453	c.1129G>A	c.(1129-1131)GAA>AAA	p.E377K	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.E377K	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	377	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		TCCATGTAACGAATGTGGGAA	0.468			NA											24	127					0	0	0.003954	0	0
HDAC9	9734	broad.mit.edu	37	7	18767237	18767237	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:18767237C>G	uc003suh.2	+	12	1798	c.1757C>G	c.(1756-1758)TCT>TGT	p.S586C	HDAC9_uc003sue.2_Missense_Mutation_p.S586C|HDAC9_uc011jyd.1_Missense_Mutation_p.S586C|HDAC9_uc003sui.2_Missense_Mutation_p.S589C|HDAC9_uc003suj.2_Missense_Mutation_p.S545C|HDAC9_uc003sua.1_Missense_Mutation_p.S564C|HDAC9_uc010kue.1_Missense_Mutation_p.S241C	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	586					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CGTGCGCTCTCTGTGCGCCAA	0.542			NA											8	10					0	0	0.006214	0	0
HDAC9	9734	broad.mit.edu	37	7	18767262	18767262	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:18767262G>T	uc003suh.2	+	12	1823	c.1782G>T	c.(1780-1782)GCG>GCT	p.A594A	HDAC9_uc003sue.2_Silent_p.A594A|HDAC9_uc011jyd.1_Silent_p.A594A|HDAC9_uc003sui.2_Silent_p.A597A|HDAC9_uc003suj.2_Silent_p.A553A|HDAC9_uc003sua.1_Silent_p.A572A|HDAC9_uc010kue.1_Silent_p.A249A	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	594					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CGCTGGCTGCGGTTGGCATGG	0.567			NA											10	10					9.70103e-10	1.15278e-09	0.008291	1	0
HOXA5	3202	broad.mit.edu	37	7	27181551	27181551	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:27181551A>G	uc003syn.1	-	2	777	c.716T>C	c.(715-717)ATT>ACT	p.I239T		NM_019102	NP_061975	P20719	HXA5_HUMAN	homeobox A5	239	Homeobox.				negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCAGATTTTAATTTGTCTCTC	0.498	Colon(119;75 2200 7557 42868)		NA									OREG0017911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	94					0	0	0.00361	0	0
CCDC129	223075	broad.mit.edu	37	7	31683324	31683324	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:31683324C>T	uc003tcj.1	+	11	3333	c.2340C>T	c.(2338-2340)ACC>ACT	p.T780T	CCDC129_uc011kad.1_Silent_p.T790T|CCDC129_uc003tci.1_Silent_p.T631T|CCDC129_uc011kae.1_Silent_p.T806T|CCDC129_uc003tck.1_Silent_p.T688T	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	780											0						AGCCCCTCACCAAATCCGTCT	0.512			NA											25	71					0	0	0.00632	0	0
AMPH	273	broad.mit.edu	37	7	38433708	38433708	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:38433708C>A	uc003tgu.2	-	18	1574	c.1505G>T	c.(1504-1506)GGG>GTG	p.G502V	AMPH_uc003tgv.2_Missense_Mutation_p.G460V|AMPH_uc003tgt.2_Missense_Mutation_p.G387V|AMPH_uc003tgw.1_Missense_Mutation_p.G525V|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	502					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TACTCCTTCCCCGGCAGGGAC	0.582			NA											76	116					7.31121e-38	9.83788e-38	0.00361	1	0
GCK	2645	broad.mit.edu	37	7	44191930	44191930	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:44191930C>T	uc003tkl.2	-	3	773	c.303G>A	c.(301-303)GTG>GTA	p.V101V	GCK_uc003tkj.1_Silent_p.V100V|GCK_uc003tkk.1_Silent_p.V102V	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	101					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GTTTGGTCTTCACGCTCCACT	0.622			NA											41	133					0	0	0.011902	0	0
ZNF713	349075	broad.mit.edu	37	7	56006821	56006821	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:56006821C>A	uc003trc.1	+	4	453	c.415C>A	c.(415-417)CAT>AAT	p.H139N	ZNF713_uc003tra.1_Missense_Mutation_p.H152N|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTTTGATTACCATCCAGAGTT	0.398			NA											18	27					1.33834e-09	1.58693e-09	0.007413	1	0
ZNF479	90827	broad.mit.edu	37	7	57188633	57188633	+	Silent	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:57188633G>T	uc010kzo.2	-	5	760	c.489C>A	c.(487-489)GTC>GTA	p.V163V		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			CAAAGACTTTGACATATTTAT	0.308			NA											13	37					8.60227e-14	1.05652e-13	0.004007	1	0
HIP1	3092	broad.mit.edu	37	7	75174020	75174020	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:75174020G>C	uc003uds.1	-	27	2780	c.2739C>G	c.(2737-2739)AGC>AGG	p.S913R	HIP1_uc011kfz.1_Missense_Mutation_p.S739R	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	913	Important for actin binding (By similarity).|I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GCTGGGCTGTGCTAGCAGCAA	0.473			NA	T	PDGFRB	CMML								14	36					0	0	0.00245	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86522305	86522305	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:86522305C>T	uc011kha.1	-	20	2982	c.2797G>A	c.(2797-2799)GGT>AGT	p.G933S	KIAA1324L_uc003uif.1_Missense_Mutation_p.G693S|KIAA1324L_uc011kgz.1_Missense_Mutation_p.G819S|KIAA1324L_uc003uie.2_Missense_Mutation_p.G766S	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	933	Helical; (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					GCTCCCACACCGGCTCCCACC	0.453			NA											42	63					0	0	0.006999	0	0
ADAM22	53616	broad.mit.edu	37	7	87746095	87746095	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:87746095A>C	uc003ujn.2	+	7	652	c.573A>C	c.(571-573)AGA>AGC	p.R191S	ADAM22_uc003uji.1_Missense_Mutation_p.R190S|ADAM22_uc003ujj.1_Missense_Mutation_p.R191S|ADAM22_uc003ujk.1_Missense_Mutation_p.R191S|ADAM22_uc003ujl.1_Missense_Mutation_p.R191S|ADAM22_uc003ujm.2_Missense_Mutation_p.R191S|ADAM22_uc003ujo.2_Missense_Mutation_p.R191S|ADAM22_uc003ujp.1_Missense_Mutation_p.R243S	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	191					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ACAAATCCAGACTGTTTGAAT	0.343			NA											5	19					0	0	0.001168	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764557	92764557	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:92764557T>C	uc003umh.1	-	5	1944	c.728A>G	c.(727-729)GAC>GGC	p.D243G	SAMD9L_uc003umj.1_Missense_Mutation_p.D243G|SAMD9L_uc003umi.1_Missense_Mutation_p.D243G|SAMD9L_uc010lfb.1_Missense_Mutation_p.D243G|SAMD9L_uc003umk.1_Missense_Mutation_p.D243G|SAMD9L_uc010lfc.1_Missense_Mutation_p.D243G|SAMD9L_uc010lfd.1_Missense_Mutation_p.D243G|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	243										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ATGGGGTTTGTCCTTGACTCC	0.398			NA											31	47					0	0	0.009535	0	0
CCDC132	55610	broad.mit.edu	37	7	92923899	92923899	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:92923899G>T	uc003umo.2	+	14	1246	c.1118G>T	c.(1117-1119)CGT>CTT	p.R373L	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.R343L|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.R93L	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	373											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AATTTTGATCGTGGCTACATA	0.274			NA											16	74					8.34094e-07	9.42217e-07	0.008871	1	0
TSC22D4	81628	broad.mit.edu	37	7	100075071	100075071	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:100075071C>A	uc003uva.2	-	2	1346	c.591G>T	c.(589-591)GAG>GAT	p.E197D	TSC22D4_uc003uvb.2_5'UTR|TSC22D4_uc011kjv.1_5'UTR|TSC22D4_uc010lgx.2_Missense_Mutation_p.E197D|TSC22D4_uc003uvc.3_Missense_Mutation_p.E197D	NM_030935	NP_112197	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	197					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGGTCTCAGGCTCTGGGGGGC	0.706			NA											8	28					5.18039e-06	5.78056e-06	0.00308	1	0
ZAN	7455	broad.mit.edu	37	7	100346018	100346018	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:100346018G>A	uc003uwj.2	+	11	1339	c.1174G>A	c.(1174-1176)GGT>AGT	p.G392S	ZAN_uc003uwk.2_Missense_Mutation_p.G392S|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	392	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTCCGGGGATGGTGGACACTG	0.552			NA											7	29					0	0	0.00308	0	0
ASZ1	136991	broad.mit.edu	37	7	117021089	117021090	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:117021089_117021090GG>AT	uc003vjb.2	-	9	983_984	c.920_921CC>AT	c.(919-921)ACC>AAT	p.T307N	ASZ1_uc011kno.1_Missense_Mutation_p.T307N|ASZ1_uc011knp.1_Missense_Mutation_p.T99N	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	307	SAM.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CTTCCCTCATGGTCAAAAGATG	0.312			NA											17	88					0	0	0.004672	0	0
GCC1	79571	broad.mit.edu	37	7	127224822	127224822	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:127224822C>T	uc003vma.2	-	1	833	c.415G>A	c.(415-417)GGC>AGC	p.G139S		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	139						Golgi membrane|plasma membrane	protein binding			ovary(2)	2						CTGCTAACGCCACTCTCGGAC	0.562			NA											15	87					0	0	0.00245	0	0
AKR1B1	231	broad.mit.edu	37	7	134143774	134143774	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:134143774G>C	uc003vrp.1	-	1	115	c.41C>G	c.(40-42)CCC>CGC	p.P14R	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	14	NADP (Potential).				C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	CCCCAGGATGGGCATCTTGGC	0.716			NA									OREG0018334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	12					0	0	0.009096	0	0
OR6V1	346517	broad.mit.edu	37	7	142750304	142750304	+	Silent	SNP	C	C	A	rs4725609		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:142750304C>A	uc011ksv.1	+	1	867	c.867C>A	c.(865-867)ACC>ACA	p.T289T		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TTATCCTTACCTTCTGCAATC	0.527			NA											11	31					3.86212e-05	4.19862e-05	0.008291	1	0
TAS2R40	259286	broad.mit.edu	37	7	142919733	142919733	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:142919733G>C	uc011ksx.1	+	1	562	c.562G>C	c.(562-564)GAG>CAG	p.E188Q		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	188	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					GTACTTCTCTGAGACCAATAT	0.463			NA											9	72					0	0	0.004482	0	0
CUL1	8454	broad.mit.edu	37	7	148427226	148427226	+	Silent	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:148427226C>G	uc010lpg.2	+	2	538	c.12C>G	c.(10-12)ACC>ACG	p.T4T	CUL1_uc003wey.2_Silent_p.T4T|CUL1_uc003wez.2_5'UTR	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	4					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGTCGTCAACCCGGAGCCAGA	0.517			NA											12	58					0	0	0.010729	0	0
XRCC2	7516	broad.mit.edu	37	7	152346361	152346361	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:152346361G>A	uc003wld.2	-	3	295	c.209C>T	c.(208-210)TCA>TTA	p.S70L		NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2	70					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		GCCACCTTCTGATTTGGGAAG	0.388			NA						Homologous_recombination					8	38					0	0	0.006214	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37728853	37728853	+	Missense_Mutation	SNP	G	G	A	rs75558150	byFrequency	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:37728853G>A	uc003xkm.1	-	4	3511	c.3467C>T	c.(3466-3468)TCG>TTG	p.S1156L	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.S485L|RAB11FIP1_uc003xko.1_Missense_Mutation_p.S485L|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	1156					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			ATGTGTCTCCGAGGGTGAGAC	0.532			NA									OREG0018713	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	52					0	0	0.001368	0	0
ST18	9705	broad.mit.edu	37	8	53084928	53084928	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:53084928C>G	uc003xqz.2	-	5	649	c.493G>C	c.(493-495)GAC>CAC	p.D165H	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.D130H|ST18_uc011lds.1_Missense_Mutation_p.D70H|ST18_uc003xra.2_Missense_Mutation_p.D165H|ST18_uc003xrb.2_Missense_Mutation_p.D165H	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	165						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AAGCACTCGTCTGCTTCATCG	0.398			NA											7	52					0	0	0.00308	0	0
TRPA1	8989	broad.mit.edu	37	8	72946612	72946612	+	Silent	SNP	T	T	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:72946612T>C	uc003xza.2	-	22	2731	c.2556A>G	c.(2554-2556)AGA>AGG	p.R852R	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	852	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AATTTTCAAATCTAGAAAAGT	0.269			NA											5	16					0	0	0.001168	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766341	77766341	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:77766341C>A	uc003yav.2	+	10	7436	c.7049C>A	c.(7048-7050)CCC>CAC	p.P2350H	ZFHX4_uc003yau.1_Missense_Mutation_p.P2395H|ZFHX4_uc003yaw.1_Missense_Mutation_p.P2350H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2350	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATTCCATCACCCAAACCAGAA	0.547			NA								HNSCC(33;0.089)			29	53					5.61819e-17	7.07428e-17	0.005443	1	0
RUNX1T1	862	broad.mit.edu	37	8	93088214	93088214	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:93088214C>T	uc003yfd.2	-	1	151	c.67G>A	c.(67-69)GGG>AGG	p.G23R	RUNX1T1_uc003yfe.1_Intron|RUNX1T1_uc010mao.2_5'UTR|RUNX1T1_uc011lgi.1_Intron|RUNX1T1_uc003yfh.1_Intron	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	23					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCAAAGTTCCCTTTTTTCCGG	0.343			NA											35	31					0	0	0.003755	0	0
CSMD3	114788	broad.mit.edu	37	8	113304782	113304782	+	Silent	SNP	A	A	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:113304782A>C	uc003ynu.2	-	55	8931	c.8772T>G	c.(8770-8772)CCT>CCG	p.P2924P	CSMD3_uc003yns.2_Silent_p.P2126P|CSMD3_uc003ynt.2_Silent_p.P2884P|CSMD3_uc011lhx.1_Silent_p.P2755P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2924	Extracellular (Potential).|Sushi 19.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACATAGGTGGAGGATGGCTCC	0.408			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			63	43					0	0	0.00361	0	0
TRPS1	7227	broad.mit.edu	37	8	116632237	116632237	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:116632237C>A	uc003ynz.2	-	2	508	c.49G>T	c.(49-51)GAG>TAG	p.E17*	TRPS1_uc011lhy.1_Nonsense_Mutation_p.E21*|TRPS1_uc003yny.2_Nonsense_Mutation_p.E30*|TRPS1_uc010mcy.2_Nonsense_Mutation_p.E17*	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	17					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ATCTGGCCCTCGCCTTCACTT	0.438			NA							Langer-Giedion_syndrome				26	44					1.39806e-14	1.73258e-14	0.008361	1	0
COL14A1	7373	broad.mit.edu	37	8	121354682	121354682	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:121354682C>T	uc003yox.2	+	44	5150	c.4885C>T	c.(4885-4887)CAG>TAG	p.Q1629*	COL14A1_uc003yoz.2_Nonsense_Mutation_p.Q594*	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1629					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACAGCTCATCCAGAGTAAGTA	0.458			NA											7	47					0	0	0.001984	0	0
FAM135B	51059	broad.mit.edu	37	8	139164596	139164596	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:139164596G>C	uc003yuy.2	-	13	2293	c.2122C>G	c.(2122-2124)CCC>GCC	p.P708A	FAM135B_uc003yux.2_Missense_Mutation_p.P609A|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.P270A|FAM135B_uc003yvb.2_Missense_Mutation_p.P270A	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	708										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CGATCACTGGGCAACTCCAGA	0.537			NA								HNSCC(54;0.14)			23	12					0	0	0.002299	0	0
COL22A1	169044	broad.mit.edu	37	8	139774680	139774680	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:139774680C>T	uc003yvd.2	-	17	2280	c.1833G>A	c.(1831-1833)GGG>GGA	p.G611G	COL22A1_uc011ljo.1_5'Flank	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	611	Pro-rich.|Gly-rich.|Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCCAGGCTTCCCAGGGAATC	0.567			NA								HNSCC(7;0.00092)			17	18					0	0	0.008871	0	0
ZNF707	286075	broad.mit.edu	37	8	144776287	144776287	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:144776287G>A	uc003yze.3	+	7	1018	c.703G>A	c.(703-705)GAG>AAG	p.E235K	ZNF707_uc010mfh.2_Missense_Mutation_p.E235K|ZNF707_uc010mfi.2_Missense_Mutation_p.E235K|ZNF707_uc003yzf.3_Missense_Mutation_p.E235K|ZNF707_uc003yzh.3_Missense_Mutation_p.E162K|ZNF707_uc011lkq.1_RNA|BREA2_uc010mfj.1_5'Flank	NM_173831	NP_776192	Q96C28	ZN707_HUMAN	zinc finger protein 707	235	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;5.6e-41)|Epithelial(56;1.02e-39)|all cancers(56;9.65e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTTCTGCTGCGAGGCCTGCGG	0.662			NA											4	12					0	0	0.009096	0	0
SCRIB	23513	broad.mit.edu	37	8	144891822	144891822	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr8:144891822C>T	uc003yzp.1	-	14	1604	c.1597G>A	c.(1597-1599)GAG>AAG	p.E533K	SCRIB_uc003yzo.1_Missense_Mutation_p.E533K	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	533	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGCTCAGCCTCAGAGACTGTG	0.667	Pancreas(51;966 1133 10533 14576 29674)		NA											9	80					0	0	0.004482	0	0
GLDC	2731	broad.mit.edu	37	9	6602126	6602126	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:6602126T>A	uc003zkc.2	-	8	1331	c.1138A>T	c.(1138-1140)AAC>TAC	p.N380Y		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	380					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GTACAGATGTTGCTGGTAGCC	0.408			NA											8	21					0	0	0.004482	0	0
MPDZ	8777	broad.mit.edu	37	9	13119517	13119517	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:13119517A>C	uc010mia.1	-	38	5420	c.5363T>G	c.(5362-5364)GTT>GGT	p.V1788G	MPDZ_uc003zkx.3_Missense_Mutation_p.V53G|MPDZ_uc003zky.3_Missense_Mutation_p.V322G|MPDZ_uc010mib.2_Missense_Mutation_p.V493G|MPDZ_uc010mhx.2_Missense_Mutation_p.V610G|MPDZ_uc011lmm.1_Missense_Mutation_p.V647G|MPDZ_uc003zkz.3_Missense_Mutation_p.V481G|MPDZ_uc010mhy.2_Missense_Mutation_p.V1788G|MPDZ_uc010mhz.2_Missense_Mutation_p.V1755G|MPDZ_uc011lmn.1_Missense_Mutation_p.V1755G|MPDZ_uc003zlb.3_Missense_Mutation_p.V1788G	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1788	PDZ 11.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CAAAGCGGCAACCGCTTCTTG	0.393			NA											11	34					0	0	0.008291	0	0
FAM154A	158297	broad.mit.edu	37	9	18928121	18928121	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:18928121G>A	uc003zni.1	-	4	1632	c.1354C>T	c.(1354-1356)CAG>TAG	p.Q452*	FAM154A_uc010mip.1_Nonsense_Mutation_p.Q260*	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	452										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		CTGCTCTGCTGAGAGCCTGCC	0.453			NA											19	32					0	0	0.006122	0	0
TAF1L	138474	broad.mit.edu	37	9	32633792	32633792	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:32633792G>T	uc003zrg.1	-	1	1876	c.1786C>A	c.(1786-1788)CAA>AAA	p.Q596K	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	596					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGACCCTGTTGCTTGGGGAAA	0.483			NA											66	692					3.30712e-30	4.38553e-30	0.00361	1	0
CHMP5	51510	broad.mit.edu	37	9	33266023	33266023	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:33266023G>C	uc003zsl.3	+	3	440	c.85G>C	c.(85-87)GAA>CAA	p.E29Q	SUGT1P1_uc010mjq.1_Intron|BAG1_uc003zsi.2_5'Flank|BAG1_uc003zsj.2_5'Flank|BAG1_uc003zsk.2_5'Flank|CHMP5_uc003zsm.3_Missense_Mutation_p.E29Q|CHMP5_uc011lnv.1_Missense_Mutation_p.E29Q	NM_016410	NP_057494	Q9NZZ3	CHMP5_HUMAN	chromatin modifying protein 5	29	Potential.				cellular membrane organization|protein transport	cytosol|endosome membrane	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			CAGTAGAGCAGAATCCATTGA	0.448			NA											16	26					0	0	0.00499	0	0
CA9	768	broad.mit.edu	37	9	35675908	35675908	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:35675908T>G	uc003zxo.3	+	3	626	c.584T>G	c.(583-585)CTG>CGG	p.L195R	C9orf100_uc003zxl.2_5'Flank|CA9_uc003zxp.3_Missense_Mutation_p.L195R	NM_001216	NP_001207	Q16790	CAH9_HUMAN	carbonic anhydrase IX precursor	195	Extracellular.|Catalytic.				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			ovary(4)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GAACTGCGCCTGCGCAACAAT	0.731			NA											16	60					0	0	0.006122	0	0
FAM75A2	642265	broad.mit.edu	37	9	39888179	39888179	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:39888179C>A	uc004abp.2	+	4	1195	c.1166C>A	c.(1165-1167)TCG>TAG	p.S389*		NM_001040065	NP_001035154	Q5RGS2	F75A2_HUMAN	hypothetical protein LOC642265	389						integral to membrane					0				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GGAGAGAACTCGAAACAGCTG	0.483			NA											33	39					1.67305e-13	2.05023e-13	0.00623	1	0
RORB	6096	broad.mit.edu	37	9	77286800	77286800	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:77286800G>C	uc004aji.2	+	9	1289	c.1240G>C	c.(1240-1242)GAT>CAT	p.D414H	RORB_uc004ajh.2_Missense_Mutation_p.D403H	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	414	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TCACCTGGATGATGAGACCTT	0.428			NA											13	19					0	0	0.003163	0	0
OMD	4958	broad.mit.edu	37	9	95179237	95179237	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:95179237G>A	uc004asd.3	-	2	973	c.604C>T	c.(604-606)CTG>TTG	p.L202L	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron	NM_005014	NP_005005	Q99983	OMD_HUMAN	osteomodulin precursor	202	LRR 5.				cell adhesion	proteinaceous extracellular matrix				ovary(2)	2						TCTTTTAGCAGAGAATCATGA	0.378			NA	T	USP6	aneurysmal bone cysts								19	47					0	0	0.006122	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123169402	123169402	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:123169402G>A	uc004bkf.2	-	32	5032	c.4851C>T	c.(4849-4851)AGC>AGT	p.S1617S	CDK5RAP2_uc010mvi.2_Silent_p.S626S|CDK5RAP2_uc004bke.2_Silent_p.S902S|CDK5RAP2_uc004bkg.2_Intron|CDK5RAP2_uc011lxw.1_Silent_p.S882S|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Silent_p.S882S|CDK5RAP2_uc011lya.1_Silent_p.S882S|CDK5RAP2_uc004bkh.1_Silent_p.S1387S|CDK5RAP2_uc004bki.2_3'UTR	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1617					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CCTTGAGCCTGCTCTGCAGAG	0.602			NA											14	35					0	0	0.004007	0	0
STRBP	55342	broad.mit.edu	37	9	125895246	125895246	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:125895246G>C	uc004bns.2	-	17	2205	c.1775C>G	c.(1774-1776)GCA>GGA	p.A592G	STRBP_uc004bnt.2_Missense_Mutation_p.A410G|STRBP_uc004bnu.2_Missense_Mutation_p.A578G|STRBP_uc004bnv.2_Missense_Mutation_p.A592G|STRBP_uc004bnr.2_Missense_Mutation_p.A151G	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	592					multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						AACGCCCTTTGCCTGTTAAAA	0.403			NA											21	17					0	0	0.012319	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134525549	134525549	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:134525549G>A	uc004cbc.2	-	3	361	c.231C>T	c.(229-231)ACC>ACT	p.T77T	RAPGEF1_uc004cbb.2_Silent_p.T95T|RAPGEF1_uc010mzn.2_Silent_p.T82T|RAPGEF1_uc004cbd.2_Silent_p.T82T	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	77					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CCACAGCACTGGTGGACATAA	0.502			NA											9	12					0	0	0.006214	0	0
VAV2	7410	broad.mit.edu	37	9	136642532	136642532	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:136642532C>A	uc004ces.2	-	23	1990	c.1944G>T	c.(1942-1944)AAG>AAT	p.K648N	VAV2_uc004cer.2_Missense_Mutation_p.K638N|VAV2_uc004cet.1_Missense_Mutation_p.K187N	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	648	SH3 1.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CAGGGCAGGGCTTCACAGATG	0.597			NA											41	60					1.61863e-15	2.02421e-15	0.00361	1	0
TRAF2	7186	broad.mit.edu	37	9	139794921	139794921	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:139794921C>T	uc010nbu.2	+	5	488	c.315C>T	c.(313-315)GCC>GCT	p.A105A	TRAF2_uc010nbv.1_Silent_p.A105A|TRAF2_uc004cjv.2_Silent_p.A105A|TRAF2_uc011mek.1_Silent_p.A94A|TRAF2_uc010nbw.2_Silent_p.A105A	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	105					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		GCCTGCCGGCCGTCTGTCCCA	0.597			NA											3	20					0	0	0.009096	0	0
TUBBP5	643224	broad.mit.edu	37	9	141071425	141071425	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:141071425C>T	uc004com.2	+	4	1089	c.828C>T	c.(826-828)AAC>AAT	p.N276N	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TCCCCGACAACGTAAAAACAG	0.502			NA											30	31					0	0	0.00874	0	0
OFD1	8481	broad.mit.edu	37	X	13778481	13778481	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:13778481G>T	uc004cvp.3	+	16	2261	c.1902G>T	c.(1900-1902)AGG>AGT	p.R634S	OFD1_uc004cvr.3_Missense_Mutation_p.R201S|OFD1_uc011mil.1_Missense_Mutation_p.R201S|OFD1_uc004cvq.3_Missense_Mutation_p.R494S|OFD1_uc010nen.2_Missense_Mutation_p.R633S|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.R593S|OFD1_uc004cvv.3_Missense_Mutation_p.R593S	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	634	Potential.|Mediates the interaction with SDCCAG8.|Mediates homooligomerization.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						CTAAGGCAAGGGTCAAAGAGC	0.468			NA											25	23					1.85244e-09	2.19179e-09	0.00333	1	0
XK	7504	broad.mit.edu	37	X	37587654	37587654	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:37587654G>T	uc004ddq.2	+	3	1356	c.1274G>T	c.(1273-1275)AGC>ATC	p.S425I		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	425	Cytoplasmic (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				ACACCTTCTAGCAGTAAAACA	0.473			NA											41	30					1.63429e-32	2.18303e-32	0.00361	1	0
USP11	8237	broad.mit.edu	37	X	47104483	47104483	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:47104483G>A	uc004dhp.2	+	16	2284	c.2284G>A	c.(2284-2286)GAG>AAG	p.E762K	USP11_uc004dhq.2_Missense_Mutation_p.E488K	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	762					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GGTAGAGGCTGAGGTAAATGA	0.557			NA											3	6					0	0	0.004672	0	0
SHROOM4	57477	broad.mit.edu	37	X	50350668	50350668	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:50350668C>A	uc004dpe.2	-	6	3500	c.3474G>T	c.(3472-3474)GAG>GAT	p.E1158D	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1158	Glu-rich.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GGGGTGGCAGctcctcttcct	0.279			NA											9	6					0.000442599	0.000470905	0.006214	1	0
MSN	4478	broad.mit.edu	37	X	64955189	64955189	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:64955189G>T	uc004dwf.2	+	8	1054	c.856G>T	c.(856-858)GGG>TGG	p.G286W		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	286	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CTTGTGCATGGGGAACCATGA	0.537			NA	T	ALK	ALCL								12	4					2.61681e-11	3.15051e-11	0.00245	1	0
ITGB1BP2	26548	broad.mit.edu	37	X	70524989	70524989	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:70524989G>A	uc004dzr.1	+	11	1020	c.991G>A	c.(991-993)GAT>AAT	p.D331N	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_Missense_Mutation_p.D313N	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	331	Asp/Glu-rich (acidic).				muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					CGATTCAGATGATGATCTGAG	0.507			NA											3	7					0	0	0.009096	0	0
ABCB7	22	broad.mit.edu	37	X	74280087	74280087	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:74280087C>G	uc004eca.2	-	15	2039	c.2014G>C	c.(2014-2016)GAT>CAT	p.D672H	ABCB7_uc004ebz.2_Missense_Mutation_p.D673H|ABCB7_uc011mqn.1_Missense_Mutation_p.D646H|ABCB7_uc010nls.2_Missense_Mutation_p.D633H|ABCB7_uc010nlt.2_Missense_Mutation_p.D632H	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	672	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						TCATCTGCATCAACCACTGTT	0.348			NA											5	14					0	0	0.001168	0	0
BRWD3	254065	broad.mit.edu	37	X	79932289	79932289	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:79932289C>T	uc004edt.2	-	41	5491	c.5228G>A	c.(5227-5229)AGA>AAA	p.R1743K	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.R1339K|BRWD3_uc004edp.2_Missense_Mutation_p.R1572K|BRWD3_uc004edq.2_Missense_Mutation_p.R1339K|BRWD3_uc010nmj.1_Missense_Mutation_p.R1339K|BRWD3_uc004edr.2_Missense_Mutation_p.R1413K|BRWD3_uc004eds.2_Missense_Mutation_p.R1339K|BRWD3_uc004edu.2_Missense_Mutation_p.R1413K|BRWD3_uc004edv.2_Missense_Mutation_p.R1339K|BRWD3_uc004edw.2_Missense_Mutation_p.R1339K|BRWD3_uc004edx.2_Missense_Mutation_p.R1339K|BRWD3_uc004edy.2_Missense_Mutation_p.R1339K|BRWD3_uc004edz.2_Missense_Mutation_p.R1413K|BRWD3_uc004eea.2_Missense_Mutation_p.R1413K|BRWD3_uc004eeb.2_Missense_Mutation_p.R1339K|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1743										ovary(4)	4						TCGAGGCAGTCTACTGAAACG	0.368			NA											8	17					0	0	0.006214	0	0
RAB40AL	282808	broad.mit.edu	37	X	102192642	102192642	+	Silent	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:102192642C>T	uc004ejs.2	+	1	443	c.396C>T	c.(394-396)TTC>TTT	p.F132F		NM_001031834	NP_001027004	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	132					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			ovary(2)	2						ATCTGGCATTCAAGAGGCAGG	0.552			NA											15	22					0	0	0.010504	0	0
CHRDL1	91851	broad.mit.edu	37	X	109964630	109964630	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:109964630T>A	uc004eou.3	-	5	779	c.430A>T	c.(430-432)ACC>TCC	p.T144S	CHRDL1_uc004eov.2_Missense_Mutation_p.T138S|CHRDL1_uc004eow.2_Missense_Mutation_p.T143S|CHRDL1_uc010nps.2_Missense_Mutation_p.T143S|CHRDL1_uc004eot.2_Intron|CHRDL1_uc011mss.1_Intron|CHRDL1_uc004eox.3_Missense_Mutation_p.T137S	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	137	VWFC 2.				BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						CTGCACTGGGTGCATTGATTG	0.478			NA											112	69					0	0	0.00361	0	0
CAPN6	827	broad.mit.edu	37	X	110497506	110497507	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:110497506_110497507CC>AA	uc004epc.1	-	3	458_459	c.290_291GG>TT	c.(289-291)TGG>TTT	p.W97F	CAPN6_uc011msu.1_5'UTR	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	97	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						ATACCTTTGTCCAATGAGACTC	0.436			NA											33	17					0	0	0.004672	0	0
CT47B1	643311	broad.mit.edu	37	X	120009314	120009314	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:120009314C>T	uc011muc.1	-	1	466	c.211G>A	c.(211-213)GGC>AGC	p.G71S		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	71											0						GCGGCCAGGCCTGCCGCCTGC	0.622			NA											25	15					0	0	0.004656	0	0
ODZ1	10178	broad.mit.edu	37	X	123517897	123517897	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:123517897C>T	uc004euj.2	-	29	6927	c.6863G>A	c.(6862-6864)AGC>AAC	p.S2288N	ODZ1_uc011muj.1_Missense_Mutation_p.S2294N|ODZ1_uc010nqy.2_Missense_Mutation_p.S2295N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2288	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AATCTCCGAGCTTGTGTGGTT	0.443			NA											49	32					0	0	0.00361	0	0
USP26	83844	broad.mit.edu	37	X	132160639	132160639	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:132160639T>A	uc010nrm.1	-	6	2080	c.1610A>T	c.(1609-1611)CAG>CTG	p.Q537L	USP26_uc011mvf.1_Missense_Mutation_p.Q537L	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	537					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					GATGACTTCCTGGTCATTCTT	0.408	NSCLC(104;342 1621 36940 47097 52632)		NA											51	32					0	0	0.00361	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995288	140995288	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:140995288G>A	uc004fbt.2	+	4	2384	c.2098G>A	c.(2098-2100)GAG>AAG	p.E700K	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	700							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTCCTCTTGAGGGAGAGGA	0.562			NA								HNSCC(15;0.026)			27	66					0	0	0.004656	0	0
PASD1	139135	broad.mit.edu	37	X	150773189	150773189	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:150773189A>T	uc004fev.3	+	3	432	c.100A>T	c.(100-102)AAC>TAC	p.N34Y		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	34	PAS.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGATTACTTCAACCAAGTGAC	0.313			NA											6	5					0	0	0.001984	0	0
L1CAM	3897	broad.mit.edu	37	X	153130418	153130418	+	Silent	SNP	G	G	A			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:153130418G>A	uc004fjb.2	-	22	3012	c.2904C>T	c.(2902-2904)TTC>TTT	p.F968F	L1CAM_uc004fjc.2_Silent_p.F968F|L1CAM_uc010nuo.2_Silent_p.F963F	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	968	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCGAAGGTTGAAGGACAGTT	0.657			NA											36	73					0	0	0.004289	0	0
DDR2	4921	broad.mit.edu	37	1	162731110	162731110	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr1:162731110delT	uc001gcf.2	+	10	1430	c.965delT	c.(964-966)CTTfs	p.L322fs	DDR2_uc001gcg.2_Frame_Shift_Del_p.L322fs	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	322	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCCTTCCCCCTTGTCCTGGAT	0.502	NSCLC(161;314 2006 8283 19651 23192)		NA											19	41	---	---	---	---	NA	NA	NA	NA	NA
MMRN2	79812	broad.mit.edu	37	10	88703746	88703746	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr10:88703746delG	uc001kea.2	-	6	922	c.795delC	c.(793-795)GACfs	p.D265fs	MMRN2_uc010qmn.1_Intron|MMRN2_uc009xtb.2_Frame_Shift_Del_p.D222fs	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	265						extracellular space				large_intestine(1)	1						TGGCCTCCACGTCAAGAGACA	0.572			NA											29	36	---	---	---	---	NA	NA	NA	NA	NA
PAK1	5058	broad.mit.edu	37	11	77069990	77069992	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	CAT	CAT	-	-	CAT	CAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:77069990_77069992delCAT	uc001oyh.3	-	6	1081_1083	c.548_550delATG	c.(547-552)GATGCT>GCT	p.D183del	PAK1_uc010rso.1_In_Frame_Del_p.D85del|PAK1_uc001oyg.3_In_Frame_Del_p.D183del|PAK1_uc001oyi.1_In_Frame_Del_p.D183del|PAK1_uc010rsn.1_5'UTR	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	183	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					GGTGGGGTAGcatcatcatcatc	0.429			NA											11	288	---	---	---	---	NA	NA	NA	NA	NA
PGR	5241	broad.mit.edu	37	11	100909932	100909932	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:100909932delG	uc001pgh.2	-	8	3460	c.2717delC	c.(2716-2718)CCAfs	p.P906fs	PGR_uc001pgg.2_Frame_Shift_Del_p.P287fs|PGR_uc001pgi.2_Frame_Shift_Del_p.P804fs|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	906	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CATCATTTCTGGAAATTCAAC	0.378	Pancreas(124;2271 2354 21954 22882)		NA											9	42	---	---	---	---	NA	NA	NA	NA	NA
OR10G4	390264	broad.mit.edu	37	11	123886543	123886543	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr11:123886543delG	uc010sac.1	+	1	262	c.262delG	c.(262-264)GGCfs	p.G88fs		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTCCCCAAGCGGCAGGGCTAT	0.532			NA											10	57	---	---	---	---	NA	NA	NA	NA	NA
FRG1B	284802	broad.mit.edu	37	20	29628226	29628226	+	Splice_Site	DEL	G	G	-	rs78710112	by1000genomes	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:29628226delG	uc010ztl.1	+	3	171	c.139_splice	c.e3-1	p.G47_splice	FRG1B_uc002wvm.1_Splice_Site|FRG1B_uc010ztj.1_Splice_Site|FRG1B_uc010gdr.1_Splice_Site|FRG1B_uc010ztk.1_Splice_Site					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTTTCACTTAGGGGAAAATGG	0.318			NA											10	100	---	---	---	---	NA	NA	NA	NA	NA
TOX2	84969	broad.mit.edu	37	20	42635313	42635313	+	Frame_Shift_Del	DEL	G	G	-	rs139380167	byFrequency	TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:42635313delG	uc002xlf.3	+	3	336	c.319delG	c.(319-321)GGCfs	p.G107fs	TOX2_uc010ggo.2_Frame_Shift_Del_p.G98fs|TOX2_uc002xle.3_Frame_Shift_Del_p.G56fs|TOX2_uc010ggp.2_Frame_Shift_Del_p.G56fs|TOX2_uc002xlg.2_Frame_Shift_Del_p.G56fs	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	107	Required for transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCTGTGCCACGGCCTCACCCC	0.622			NA											27	64	---	---	---	---	NA	NA	NA	NA	NA
CABLES2	81928	broad.mit.edu	37	20	60966081	60966081	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr20:60966081delA	uc002ycv.2	-	10	1390	c.1383delT	c.(1381-1383)TATfs	p.Y461fs		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	461					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			TCTCGGGAAGATACAGGGCCA	0.567			NA											32	47	---	---	---	---	NA	NA	NA	NA	NA
RPL3	6122	broad.mit.edu	37	22	39714471	39714472	+	Frame_Shift_Ins	INS	-	-	G	rs141020322		TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr22:39714471_39714472insG	uc003axi.2	-	2	197_198	c.129_130insC	c.(127-132)CTCACAfs	p.L43fs	RPL3_uc003axh.2_Frame_Shift_Ins_p.L43fs|RPL3_uc003axj.2_5'UTR|RPL3_uc011aoj.1_Frame_Shift_Ins_p.L43fs|RPL3_uc010gxx.2_5'UTR|RPL3_uc003axg.2_5'UTR|RPL3_uc003axk.1_5'UTR	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	43_44					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					AGGAAGGCTGTGAGGTGGACCG	0.584			NA											32	64	---	---	---	---	NA	NA	NA	NA	NA
HCLS1	3059	broad.mit.edu	37	3	121351394	121351394	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:121351394delG	uc003eeh.3	-	12	1150	c.1025delC	c.(1024-1026)CCAfs	p.P342fs	HCLS1_uc011bjj.1_Frame_Shift_Del_p.P305fs|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	342					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		GGGCAGAGCTGGGGGCTCCTC	0.458			NA											12	85	---	---	---	---	NA	NA	NA	NA	NA
SLC9A9	285195	broad.mit.edu	37	3	143082332	143082336	+	Frame_Shift_Del	DEL	TCAAA	TCAAA	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	TCAAA	TCAAA	-	-	TCAAA	TCAAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr3:143082332_143082336delTCAAA	uc003evn.2	-	14	1776_1780	c.1594_1598delTTTGA	c.(1594-1599)TTTGACfs	p.F532fs		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	532_533					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						ATACTTGTGGTCAAAGCTATACCAC	0.415			NA											7	84	---	---	---	---	NA	NA	NA	NA	NA
LIAS	11019	broad.mit.edu	37	4	39460773	39460773	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr4:39460773delG	uc003guf.2	+	1	109	c.36delG	c.(34-36)CTGfs	p.L12fs	RPL9_uc003gub.2_5'Flank|RPL9_uc003guc.2_5'Flank|RPL9_uc011byk.1_5'Flank|RPL9_uc011byl.1_5'Flank|RPL9_uc003gud.1_5'Flank|LIAS_uc003gue.3_Frame_Shift_Del_p.L12fs|LIAS_uc011bym.1_Frame_Shift_Del_p.L12fs|LIAS_uc003gug.2_Frame_Shift_Del_p.L12fs|LIAS_uc003guh.2_Frame_Shift_Del_p.L12fs	NM_006859	NP_006850	O43766	LIAS_HUMAN	lipoic acid synthetase isoform 1 precursor	12					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding				0					Lipoic Acid(DB00166)	CCCGCACCCTGGGGCCCCGGG	0.592			NA											25	69	---	---	---	---	NA	NA	NA	NA	NA
CDHR2	54825	broad.mit.edu	37	5	176011962	176011962	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr5:176011962delG	uc003mem.1	+	19	2746	c.2680delG	c.(2680-2682)GTGfs	p.V894fs	CDHR2_uc003men.1_Frame_Shift_Del_p.V894fs	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	894	Extracellular (Potential).|Cadherin 8.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CACGCTGGTTGTGCGGGCCTG	0.612			NA											5	3	---	---	---	---	NA	NA	NA	NA	NA
ZFP57	346171	broad.mit.edu	37	6	29640858	29640858	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:29640858delG	uc011dlw.1	-	4	1181	c.1030delC	c.(1030-1032)CAGfs	p.Q344fs	ZFP57_uc003nnl.3_Frame_Shift_Del_p.Q324fs	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	260					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ACAGATGCCTGGTTCTGGGCC	0.542			NA											27	159	---	---	---	---	NA	NA	NA	NA	NA
ROS1	6098	broad.mit.edu	37	6	117677871	117677871	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr6:117677871delA	uc003pxp.1	-	25	4261	c.4062delT	c.(4060-4062)TTTfs	p.F1354fs	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1354	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTGCTTTGGCAAAGTATATCA	0.408			NA	T	GOPC|ROS1	glioblastoma|NSCLC								20	47	---	---	---	---	NA	NA	NA	NA	NA
VWC2	375567	broad.mit.edu	37	7	49842437	49842440	+	Splice_Site	DEL	GTAT	GTAT	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	GTAT	GTAT	-	-	GTAT	GTAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr7:49842437_49842440delGTAT	uc003tot.1	+	3	1382	c.826_splice	c.e3+1	p.G276_splice		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2						negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						TGCAAAAATGGTATGTGAGATCCC	0.559			NA											9	55	---	---	---	---	NA	NA	NA	NA	NA
TAF1L	138474	broad.mit.edu	37	9	32633583	32633584	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chr9:32633583_32633584insT	uc003zrg.1	-	1	2084_2085	c.1994_1995insA	c.(1993-1995)AAGfs	p.K665fs	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	665					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.K665fs*4(2)		lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCATCTTGGCCTTTTTTTTGAT	0.48			NA											11	454	---	---	---	---	NA	NA	NA	NA	NA
ENOX2	10495	broad.mit.edu	37	X	129771355	129771355	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7150-01A-21D-2036-08	TCGA-78-7150-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b68a9ab8-5042-437c-be61-a1cf0f9f9210	67131ca6-922d-4103-b302-ce1f13df83fa	g.chrX:129771355delC	uc004evw.2	-	12	1664	c.1246delG	c.(1246-1248)GAAfs	p.E416fs	ENOX2_uc004evx.2_Frame_Shift_Del_p.E387fs|ENOX2_uc004evy.2_Frame_Shift_Del_p.E387fs|ENOX2_uc004evv.2_Frame_Shift_Del_p.E241fs	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	416	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						TCATTTTCTTCCTTCAGAGCT	0.408	Ovarian(101;828 1506 2951 9500 35258)		NA											39	31	---	---	---	---	NA	NA	NA	NA	NA