Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	979091	979091	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:979091G>T	uc001ack.1	+	9	1827	c.1777G>T	c.(1777-1779)GTG>TTG	p.V593L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	593	Kazal-like 6.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CAGCCTGCACGTGGCCTCAGC	0.706			NA											5	57					8.12818e-05	8.7378e-05	0.001984	1	0
MST1P9	11223	broad.mit.edu	37	1	17085795	17085795	+	Silent	SNP	G	G	T	rs1057379	by1000genomes	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:17085795G>T	uc010ock.1	-	8	1026	c.1026C>A	c.(1024-1026)ATC>ATA	p.I342I	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TACAACGCCGGATCTGGTAGC	0.687			NA											5	20					1.5842e-08	1.90992e-08	0.016723	1	0
NBPF3	84224	broad.mit.edu	37	1	21804741	21804741	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:21804741A>T	uc001ber.2	+	9	1447	c.1097A>T	c.(1096-1098)GAC>GTC	p.D366V	NBPF3_uc001bes.2_Missense_Mutation_p.D310V|NBPF3_uc009vqb.2_Intron|NBPF3_uc010odm.1_Missense_Mutation_p.D296V	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	366	NBPF 2.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TACCAGTCTGACAGGAGCACC	0.512			NA											34	226					0	0	0.012213	0	0
YTHDF2	51441	broad.mit.edu	37	1	29069392	29069392	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:29069392C>G	uc001brc.2	+	4	1107	c.610C>G	c.(610-612)CCA>GCA	p.P204A	YTHDF2_uc001brd.2_Missense_Mutation_p.P201A|YTHDF2_uc010ofx.1_Missense_Mutation_p.P154A|YTHDF2_uc001bre.2_Missense_Mutation_p.P154A	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	204					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCAATGTTCCAAAAGTTGT	0.478			NA											11	64					0	0	0.010729	0	0
KCNA10	3744	broad.mit.edu	37	1	111061194	111061194	+	Missense_Mutation	SNP	G	G	C	rs140376600	byFrequency	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:111061194G>C	uc001dzt.1	-	1	604	c.216C>G	c.(214-216)GAC>GAG	p.D72E		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	72						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GCCCTGGGGGGTCAGCATAGT	0.577			NA											4	86					0	0	0.009096	0	0
SEMA6C	10500	broad.mit.edu	37	1	151107690	151107690	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:151107690C>G	uc001ewu.2	-	15	1829	c.1529G>C	c.(1528-1530)TGT>TCT	p.C510S	SEMA6C_uc001ewv.2_Missense_Mutation_p.C510S|SEMA6C_uc001eww.2_Missense_Mutation_p.C470S|SEMA6C_uc010pcq.1_Missense_Mutation_p.C510S	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	510	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTAGACAATACAGCCAGAAAA	0.627			NA											7	92					0	0	0.004482	0	0
LY9	4063	broad.mit.edu	37	1	160793521	160793521	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:160793521T>C	uc001fwu.2	+	8	1815	c.1765T>C	c.(1765-1767)TAT>CAT	p.Y589H	LY9_uc001fwv.2_Missense_Mutation_p.Y575H|LY9_uc001fww.2_Missense_Mutation_p.Y499H|LY9_uc001fwx.2_Missense_Mutation_p.Y499H|LY9_uc001fwy.1_Missense_Mutation_p.Y387H|LY9_uc001fwz.2_Missense_Mutation_p.Y227H	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	589	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CGTCACTCCATATGTCACGGA	0.512			NA											12	220					0	0	0.003163	0	0
LRRC52	440699	broad.mit.edu	37	1	165513896	165513896	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:165513896C>T	uc001gde.2	+	1	419	c.363C>T	c.(361-363)TTC>TTT	p.F121F	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	121	LRR 3.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					CATTCACTTTCTCGGTGCTCA	0.498			NA											9	273					0	0	0.004482	0	0
BLZF1	8548	broad.mit.edu	37	1	169356302	169356302	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:169356302C>T	uc001gfx.1	+	7	1522	c.1085C>T	c.(1084-1086)TCA>TTA	p.S362L	BLZF1_uc001gfy.2_Missense_Mutation_p.S362L|BLZF1_uc009wvp.1_3'UTR	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	362					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					TTTGAGTCTTCACCAACCACC	0.348			NA											5	94					0	0	0.014758	0	0
TNN	63923	broad.mit.edu	37	1	175086232	175086232	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:175086232G>C	uc001gkl.1	+	10	2390	c.2277G>C	c.(2275-2277)CAG>CAC	p.Q759H		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	759	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGAAGGAGCAGAGTAGCACTG	0.647			NA											6	140					0	0	0.001984	0	0
TEDDM1	127670	broad.mit.edu	37	1	182369568	182369568	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:182369568T>G	uc001gpe.2	-	1	184	c.53A>C	c.(52-54)CAA>CCA	p.Q18P		NM_172000	NP_741997	Q5T9Z0	TEDM1_HUMAN	putative membrane protein HE9	18						integral to membrane				ovary(2)	2						GGCACATCTTTGCTTATTCCT	0.448			NA											30	113					0	0	0.012213	0	0
CFHR5	81494	broad.mit.edu	37	1	196973882	196973882	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:196973882G>A	uc001gts.3	+	9	1550	c.1422G>A	c.(1420-1422)GTG>GTA	p.V474V		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	474	Sushi 8.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GGTCAACAGTGACGTACCGTT	0.458			NA											8	144					0	0	0.00308	0	0
PTPRC	5788	broad.mit.edu	37	1	198666011	198666011	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:198666011G>C	uc001gur.1	+	4	445	c.265G>C	c.(265-267)GAT>CAT	p.D89H	PTPRC_uc001gus.1_Missense_Mutation_p.D89H|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Intron|PTPRC_uc009wzf.1_Intron|PTPRC_uc010ppg.1_Intron|PTPRC_uc001guu.1_Missense_Mutation_p.D132H|PTPRC_uc001guv.1_Intron|PTPRC_uc001guw.1_Intron	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	89	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GGACTCTTTGGATAATGCTAG	0.398			NA											24	192					0	0	0.007291	0	0
SPATA17	128153	broad.mit.edu	37	1	217947767	217947767	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:217947767C>A	uc001hlh.1	+	7	637	c.611C>A	c.(610-612)CCT>CAT	p.P204H	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.P204H	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	204						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		CACCGAAGACCTAAAGTTAAG	0.438			NA											9	91					3.86212e-05	4.29494e-05	0.008291	1	0
GPR137B	7107	broad.mit.edu	37	1	236306205	236306205	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:236306205C>A	uc001hxq.2	+	1	374	c.283C>A	c.(283-285)CTC>ATC	p.L95I		NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	95	Helical; (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GCGGACCGTCCTCTTCTCCTT	0.587			NA											22	142					9.86323e-18	1.25976e-17	0.021523	1	0
AKT3	10000	broad.mit.edu	37	1	243727072	243727072	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:243727072C>T	uc001iab.1	-	9	979	c.898G>A	c.(898-900)GCA>ACA	p.A300T	AKT3_uc001hzz.1_Missense_Mutation_p.A300T	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	300	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			ATGGTGGCTGCATCTGTGATC	0.398			NA											5	88					0	0	0.014758	0	0
ZNF695	57116	broad.mit.edu	37	1	247162681	247162681	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:247162681G>A	uc009xgu.2	-	3	373	c.228C>T	c.(226-228)AAC>AAT	p.N76N	ZNF695_uc001ica.2_RNA|ZNF695_uc001icb.1_RNA|ZNF695_uc009xgt.1_RNA|ZNF695_uc001ibx.2_Silent_p.N76N|ZNF695_uc001iby.2_RNA|ZNF695_uc001icc.2_Silent_p.N64N	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	76	KRAB.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTGTGTTCACGTTCCAGGGCT	0.468			NA											9	84					0	0	0.006214	0	0
OR2M5	127059	broad.mit.edu	37	1	248308622	248308622	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:248308622C>A	uc010pze.1	+	1	173	c.173C>A	c.(172-174)CCC>CAC	p.P58H		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CTCCACACCCCCATGTACTTC	0.522			NA											110	371					2.96211e-45	3.85972e-45	0.01441	1	0
ZEB1	6935	broad.mit.edu	37	10	31815884	31815884	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr10:31815884G>A	uc001ivs.3	+	9	3130	c.3067G>A	c.(3067-3069)GAC>AAC	p.D1023N	ZEB1_uc001ivr.3_Missense_Mutation_p.D805N|ZEB1_uc010qee.1_Missense_Mutation_p.D805N|ZEB1_uc010qef.1_Missense_Mutation_p.D805N|ZEB1_uc001ivt.3_Missense_Mutation_p.D805N|ZEB1_uc001ivu.3_Missense_Mutation_p.D1024N|ZEB1_uc001ivv.3_Missense_Mutation_p.D1003N|ZEB1_uc010qeh.1_Missense_Mutation_p.D956N|ZEB1_uc009xlp.2_Missense_Mutation_p.D1007N	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	1023	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				GGGCGACTCGGACGAGAGAGA	0.408	Ovarian(40;423 959 14296 36701 49589)		NA											3	29					0	0	0.004672	0	0
TACR2	6865	broad.mit.edu	37	10	71168743	71168743	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr10:71168743T>C	uc001jpn.2	-	3	1271	c.676A>G	c.(676-678)AGG>GGG	p.R226G	TACR2_uc001jpm.2_Missense_Mutation_p.R14G	NM_001057	NP_001048	P21452	NK2R_HUMAN	tachykinin receptor 2	226	Cytoplasmic (Potential).				excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			prostate(1)	1					Clonidine(DB00575)|Octreotide(DB00104)	ACTGCGCGCCTCCAGAGCGTG	0.522			NA											3	30					0	0	0.004672	0	0
OR52K2	119774	broad.mit.edu	37	11	4470976	4470976	+	Missense_Mutation	SNP	A	A	C	rs147450058		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:4470976A>C	uc001lyz.1	+	1	407	c.407A>C	c.(406-408)AAG>ACG	p.K136T		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACTACACCAAGGTCCTGACT	0.552			NA											9	73					0	0	0.006214	0	0
SYT9	143425	broad.mit.edu	37	11	7335023	7335023	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:7335023G>A	uc001mfe.2	+	3	1132	c.895G>A	c.(895-897)GAA>AAA	p.E299K	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	299	Cytoplasmic (Potential).|C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CAATGACCTTGAAGCACGGAA	0.453			NA											11	268					0	0	0.010729	0	0
SCUBE2	57758	broad.mit.edu	37	11	9042630	9042630	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:9042630G>C	uc001mhh.1	-	22	3042	c.2962C>G	c.(2962-2964)CGT>GGT	p.R988G	SCUBE2_uc001mhi.1_Missense_Mutation_p.R960G|SCUBE2_uc001mhj.1_Missense_Mutation_p.R796G	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	988						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		ACTTTGGAACGTAGCAATCGG	0.488			NA											10	53					0	0	0.008291	0	0
TMEM41B	440026	broad.mit.edu	37	11	9321238	9321238	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr11:9321238C>A	uc001mhm.2	-	2	440	c.132G>T	c.(130-132)TGG>TGT	p.W44C	TMEM41B_uc001mhn.1_Missense_Mutation_p.W44C	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	44						integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		CAGCTTCTACCCAGGATTTTT	0.323			NA											5	49					0.00116845	0.00121556	0.001168	1	0
KRT81	3887	broad.mit.edu	37	12	52681054	52681054	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr12:52681054G>T	uc001sab.2	-	7	1129	c.1079C>A	c.(1078-1080)GCC>GAC	p.A360D	KRT86_uc010snq.1_Intron|KRT86_uc009zmg.2_Intron|KRT81_uc001sac.2_5'UTR	NM_002281	NP_002272	Q14533	KRT81_HUMAN	keratin, hair, basic, 1	360	Rod.|Coil 2.					keratin filament	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		ATCACTGAGGGCCGCCTCACC	0.617			NA											6	61					0.00116845	0.00121556	0.001168	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54902264	54902264	+	Missense_Mutation	SNP	G	G	A	rs149360088	byFrequency	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr12:54902264G>A	uc001sgc.3	+	5	534	c.455G>A	c.(454-456)CGG>CAG	p.R152Q	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.R102Q	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	152					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GAAGATCGGCGGATACTCATT	0.428			NA											25	238					0	0	0.004656	0	0
PTPRB	5787	broad.mit.edu	37	12	70964879	70964879	+	Silent	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr12:70964879G>T	uc001swb.3	-	11	2673	c.2643C>A	c.(2641-2643)GGC>GGA	p.G881G	PTPRB_uc010sto.1_Silent_p.G881G|PTPRB_uc010stp.1_Silent_p.G791G|PTPRB_uc001swc.3_Silent_p.G1099G|PTPRB_uc001swa.3_Silent_p.G1011G|PTPRB_uc001swd.3_Silent_p.G1098G|PTPRB_uc009zrr.1_Silent_p.G978G	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	881	Fibronectin type-III 10.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGTATTGGCGGCCTGGTGTTA	0.428			NA											6	36					5.9392e-07	6.84069e-07	0.001168	1	0
TMEM132D	121256	broad.mit.edu	37	12	130015687	130015687	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr12:130015687A>T	uc009zyl.1	-	3	1360	c.1032T>A	c.(1030-1032)GAT>GAA	p.D344E		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	344	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTCCTTGACATCCCAAATGG	0.537			NA											4	56					0	0	0.014758	0	0
C15orf29	79768	broad.mit.edu	37	15	34455835	34455835	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr15:34455835T>C	uc001zhp.2	-	2	203	c.43A>G	c.(43-45)AAT>GAT	p.N15D	C15orf29_uc010ubz.1_Intron|C15orf29_uc010uca.1_Missense_Mutation_p.N15D	NM_024713	NP_078989	Q9H079	CO029_HUMAN	hypothetical protein LOC79768	15						nucleolus				ovary(1)	1		all_lung(180;1.86e-06)		all cancers(64;5.49e-18)|GBM - Glioblastoma multiforme(113;8.91e-07)|BRCA - Breast invasive adenocarcinoma(123;0.026)|Lung(196;0.229)		TCAATCTTATTACAAAAGTTC	0.294			NA											7	45					0	0	0.00308	0	0
MAN2A2	4122	broad.mit.edu	37	15	91456505	91456505	+	Missense_Mutation	SNP	G	G	A	rs148275760		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr15:91456505G>A	uc010bnz.2	+	18	2702	c.2587G>A	c.(2587-2589)GTG>ATG	p.V863M	MAN2A2_uc002bqc.2_Missense_Mutation_p.V863M|MAN2A2_uc010uql.1_Missense_Mutation_p.V525M|MAN2A2_uc010uqm.1_Missense_Mutation_p.V442M|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	863					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTACCCAGGGGTGGAGGGGCT	0.607			NA											7	67					0	0	0.001984	0	0
CHD2	1106	broad.mit.edu	37	15	93567613	93567613	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr15:93567613A>T	uc002bsp.2	+	39	5740	c.5165A>T	c.(5164-5166)GAC>GTC	p.D1722V		NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1722					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CACCATCATGACTCCAAGCGG	0.493			NA											7	52					0	0	0.00308	0	0
A2BP1	54715	broad.mit.edu	37	16	7637294	7637294	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr16:7637294G>A	uc002cys.2	+	7	1448	c.460G>A	c.(460-462)GGC>AGC	p.G154S	A2BP1_uc010buf.1_Missense_Mutation_p.G154S|A2BP1_uc002cyr.1_Missense_Mutation_p.G153S|A2BP1_uc002cyt.2_Missense_Mutation_p.G154S|A2BP1_uc010uxz.1_Missense_Mutation_p.G197S|A2BP1_uc010uya.1_Missense_Mutation_p.G142S|A2BP1_uc002cyv.1_Missense_Mutation_p.G154S|A2BP1_uc010uyb.1_Missense_Mutation_p.G154S|A2BP1_uc002cyw.2_Missense_Mutation_p.G174S|A2BP1_uc002cyy.2_Missense_Mutation_p.G174S|A2BP1_uc002cyx.2_Missense_Mutation_p.G174S|A2BP1_uc010uyc.1_Missense_Mutation_p.G174S	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	154	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TAATGAGCGAGGCTCAAAGGT	0.299			NA											9	82					0	0	0.006214	0	0
VWA3A	146177	broad.mit.edu	37	16	22155616	22155616	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr16:22155616T>A	uc010vbq.1	+	26	2737	c.2641T>A	c.(2641-2643)TGC>AGC	p.C881S	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_5'UTR|VWA3A_uc010bxe.1_5'Flank	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	881						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		GATTTCCAGATGCATGGGTCC	0.438			NA											4	28					0	0	0.009096	0	0
CCDC135	84229	broad.mit.edu	37	16	57734101	57734101	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr16:57734101C>T	uc002emi.2	+	4	512	c.423C>T	c.(421-423)CCC>CCT	p.P141P	CCDC135_uc002emj.2_Silent_p.P141P|CCDC135_uc002emk.2_Silent_p.P141P	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	141						cytoplasm				central_nervous_system(1)	1						TGCCCTACCCCGAGCTCTACA	0.577			NA											12	162					0	0	0.010729	0	0
ALDOC	230	broad.mit.edu	37	17	26902474	26902474	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:26902474G>T	uc002hbp.2	-	2	222	c.77C>A	c.(76-78)CCG>CAG	p.P26Q	ALDOC_uc010cro.2_Missense_Mutation_p.P26Q	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	26					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					GCCTTTGCCCGGGGCTACAAT	0.572			NA									OREG0024278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	69					2.7689e-08	3.30729e-08	0.001984	1	0
GPR179	440435	broad.mit.edu	37	17	36499178	36499178	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:36499178C>T	uc002hpz.2	-	1	516	c.495G>A	c.(493-495)CAG>CAA	p.Q165Q		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	165	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCCGGGTGGCCTGCAGGGCCA	0.647			NA											8	65					0	0	0.004482	0	0
C17orf71	55181	broad.mit.edu	37	17	57290862	57290862	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:57290862C>T	uc002ixi.2	+	3	2720	c.2678C>T	c.(2677-2679)TCA>TTA	p.S893L		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	893					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TATATTCTGTCATCCTCTCAA	0.423			NA											9	157					0	0	0.004482	0	0
GRB2	2885	broad.mit.edu	37	17	73316622	73316622	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr17:73316622C>A	uc002jnx.3	-	6	838	c.481G>T	c.(481-483)GTC>TTC	p.V161F	GRB2_uc002jny.3_Missense_Mutation_p.V120F	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	161	SH3 2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	AGGGCCTGGACGTATGTCGGC	0.562			NA											7	50					7.48243e-07	8.54189e-07	0.006214	1	0
TMX3	54495	broad.mit.edu	37	18	66344295	66344295	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr18:66344295T>C	uc002lkf.2	-	16	1375	c.1240A>G	c.(1240-1242)AAA>GAA	p.K414E	TMX3_uc010xez.1_Missense_Mutation_p.K273E	NM_019022	NP_061895	Q96JJ7	TMX3_HUMAN	thioredoxin domain containing 10 precursor	414	Cytoplasmic (Potential).				cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			skin(1)	1						TTTTCACTTTTAGACACTTCA	0.463			NA											16	141					0	0	0.006122	0	0
ZNF236	7776	broad.mit.edu	37	18	74671705	74671705	+	Silent	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr18:74671705A>G	uc002lmi.2	+	29	5367	c.5169A>G	c.(5167-5169)AAA>AAG	p.K1723K	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1723	C2H2-type 28.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GAGTGTTTAAATGTGACACTT	0.512			NA											7	49					0	0	0.00308	0	0
KHSRP	8570	broad.mit.edu	37	19	6415180	6415180	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:6415180G>A	uc002mer.3	-	19	2209	c.2099C>T	c.(2098-2100)CCG>CTG	p.P700L		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	700					mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						CGTGGGCGGCGGCTGGGGGCC	0.662	Colon(55;593 1006 2067 9135 22980)		NA											7	26					0	0	0.001984	0	0
ZNF844	284391	broad.mit.edu	37	19	12187210	12187210	+	Silent	SNP	A	A	G	rs6511764	by1000genomes	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:12187210A>G	uc002mtb.2	+	4	1418	c.1275A>G	c.(1273-1275)GTA>GTG	p.V425V	ZNF844_uc010dym.1_Silent_p.V268V	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGCAGTGTAGTAAAGCCTT	0.428			NA											3	50					0	0	0.004672	0	0
ZNF44	51710	broad.mit.edu	37	19	12384105	12384105	+	Missense_Mutation	SNP	C	C	T	rs144293271	by1000genomes	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:12384105C>T	uc010xmj.1	-	5	1314	c.1109G>A	c.(1108-1110)GGA>GAA	p.G370E	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.G322E	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	370	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		TTGAAAGCTTCCAAGATGACA	0.418			NA											5	175					0	0	0.001168	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768243	31768243	+	Missense_Mutation	SNP	G	G	A	rs150738892	byFrequency	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:31768243G>A	uc002nsy.3	-	2	2521	c.2456C>T	c.(2455-2457)TCA>TTA	p.S819L		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	819					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CACCGTGGATGAGGAGGTTGC	0.527			NA											6	72					0	0	0.001984	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769932	31769932	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:31769932T>G	uc002nsy.3	-	2	832	c.767A>C	c.(766-768)AAG>ACG	p.K256T		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	256					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TTTGCGAGGCTTGGACCAGCG	0.562			NA											34	221					0	0	0.021022	0	0
ZFP14	57677	broad.mit.edu	37	19	36832176	36832177	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:36832176_36832177GC>AA	uc002odx.1	-	4	644_645	c.551_552GC>TT	c.(550-552)CGC>CTT	p.R184L	ZFP14_uc010xtd.1_Missense_Mutation_p.R185L|ZFP14_uc010eex.1_Missense_Mutation_p.R184L	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	184	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TAAGTGTTGAGCGACGAATAAA	0.411			NA											21	135					0	0	0.004672	0	0
IZUMO1	284359	broad.mit.edu	37	19	49246723	49246723	+	Nonsense_Mutation	SNP	G	G	A	rs146399718		TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr19:49246723G>A	uc002pkj.2	-	6	1026	c.478C>T	c.(478-480)CGA>TGA	p.R160*	RASIP1_uc002pki.2_5'Flank|IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	160	Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TAGGACTTTCGACAAGCGTGA	0.557			NA											4	36					0	0	0.014758	0	0
ATAD2B	54454	broad.mit.edu	37	2	24056803	24056803	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:24056803G>C	uc002rek.3	-	14	2008	c.1714C>G	c.(1714-1716)CTG>GTG	p.L572V	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rej.3_5'Flank	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	572							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATCAGGCAGGTTGAAGAGG	0.353			NA											5	36					0	0	0.001168	0	0
CRIM1	51232	broad.mit.edu	37	2	36771546	36771546	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:36771546T>C	uc002rpd.2	+	15	2690	c.2651T>C	c.(2650-2652)ATA>ACA	p.I884T		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	884	Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CCAACCAATATACCCATTGAG	0.438			NA											10	98					0	0	0.006214	0	0
MAP4K3	8491	broad.mit.edu	37	2	39481642	39481642	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:39481642C>T	uc002rro.2	-	32	2581	c.2490G>A	c.(2488-2490)GTG>GTA	p.V830V	MAP4K3_uc002rrp.2_Silent_p.V809V|MAP4K3_uc010yns.1_Silent_p.V383V	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	830	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				AGAAAGCTAGCACACTGTCTT	0.358			NA											11	93					0	0	0.016723	0	0
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	A	G	rs115341812	by1000genomes	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567			NA											3	43					0	0	0.009096	0	0
PCDP1	200373	broad.mit.edu	37	2	120395937	120395937	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:120395937G>C	uc002tmb.2	+	21	2311	c.1219G>C	c.(1219-1221)GAG>CAG	p.E407Q		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	693						cilium	calmodulin binding				0	Colorectal(110;0.196)					ATTCACCAAAGAGTCCCGCCA	0.502			NA											7	160					0	0	0.004482	0	0
UBXN4	23190	broad.mit.edu	37	2	136537772	136537773	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:136537772_136537773CC>TT	uc002tur.2	+	12	1516_1517	c.1205_1206CC>TT	c.(1204-1206)TCC>TTT	p.S402F	UBXN4_uc002tus.2_Missense_Mutation_p.S168F|UBXN4_uc002tut.2_Missense_Mutation_p.S38F	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	402	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						CCAACTGCATCCATTGTACACT	0.396			NA											8	118					0	0	0.004672	0	0
SSFA2	6744	broad.mit.edu	37	2	182774637	182774637	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:182774637G>A	uc002uoi.2	+	9	1747	c.1425G>A	c.(1423-1425)ACG>ACA	p.T475T	SSFA2_uc002uoh.2_Silent_p.T475T|SSFA2_uc002uoj.2_Silent_p.T475T|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Silent_p.T322T|SSFA2_uc002uol.2_Silent_p.T322T	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	475						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TTCAAAGTACGGAGGGAGAAG	0.373			NA											4	53					0	0	0.014758	0	0
DNAH7	56171	broad.mit.edu	37	2	196729689	196729689	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:196729689G>C	uc002utj.3	-	41	6791	c.6690C>G	c.(6688-6690)ATC>ATG	p.I2230M		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2230					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAATGTAGTTGATGAGCCAGC	0.363			NA											4	112					0	0	0.014758	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622444	234622444	+	Silent	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr2:234622444C>A	uc002vuw.2	+	1	807	c.807C>A	c.(805-807)ATC>ATA	p.I269I	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Silent_p.I269I	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	269					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		CCAGGCCGATCATGCCCAACA	0.512			NA											41	182					3.76604e-16	4.76293e-16	0.010771	1	0
CBLN4	140689	broad.mit.edu	37	20	54579155	54579155	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr20:54579155C>T	uc002xxa.2	-	1	858	c.73G>A	c.(73-75)GTC>ATC	p.V25I		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	25						cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			TGTGCCCAGACGGGCAGCCCC	0.721			NA											3	24					0	0	0.004672	0	0
KRTAP21-1	337977	broad.mit.edu	37	21	32127654	32127654	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr21:32127654C>A	uc011adi.1	-	1	43	c.43G>T	c.(43-45)GGC>TGC	p.G15C		NM_181619	NP_853650	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	15			G -> S (in a breast cancer sample; somatic mutation).			intermediate filament		p.G15S(1)		breast(1)	1						cagccacagccggagccatag	0.189			NA											37	157					3.33393e-15	4.17551e-15	0.021022	1	0
SLC25A18	83733	broad.mit.edu	37	22	18070012	18070012	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr22:18070012C>T	uc002zmp.1	+	8	1014	c.520C>T	c.(520-522)CTC>TTC	p.L174F	SLC25A18_uc010gqx.2_Missense_Mutation_p.L174F|SLC25A18_uc002zmq.1_Missense_Mutation_p.L174F	NM_031481	NP_113669	Q9H1K4	GHC2_HUMAN	solute carrier	174	Solcar 2.					integral to membrane|mitochondrial inner membrane	binding|symporter activity				0				Lung(27;0.124)	L-Glutamic Acid(DB00142)	CTGGGAGCTGCTCCGCACTCA	0.662	Colon(118;1560 1625 18964 29606 50093)		NA											10	126					0	0	0.008291	0	0
CRYBB1	1414	broad.mit.edu	37	22	27012230	27012230	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr22:27012230C>T	uc003acy.1	-	2	124	c.54G>A	c.(52-54)GGG>GGA	p.G18G		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	18	N-terminal arm.				visual perception		structural constituent of eye lens			ovary(1)	1						TGGTGTCAGGCCCTGGGTTCA	0.627			NA											13	76					0	0	0.016723	0	0
POLR3H	171568	broad.mit.edu	37	22	41926706	41926706	+	Silent	SNP	A	A	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr22:41926706A>C	uc003baf.2	-	6	606	c.546T>G	c.(544-546)GCT>GCG	p.A182A	POLR3H_uc003bae.2_RNA|POLR3H_uc003bag.2_Silent_p.A182A|POLR3H_uc003bai.2_Silent_p.A153A	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	182					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						GCGTGTACGGAGCCTCCTTCT	0.627			NA											4	28					0	0	0.009096	0	0
SUSD5	26032	broad.mit.edu	37	3	33195270	33195270	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:33195270C>G	uc003cfo.1	-	5	1272	c.854G>C	c.(853-855)GGA>GCA	p.G285A		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	285	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						CAGCCGTGATCCTGGTGAATC	0.527			NA											5	64					0	0	0.014758	0	0
ULK4	54986	broad.mit.edu	37	3	41939949	41939949	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:41939949T>A	uc003ckv.3	-	14	1524	c.1323A>T	c.(1321-1323)AAA>AAT	p.K441N	ULK4_uc003ckw.2_Missense_Mutation_p.K441N|ULK4_uc003ckx.1_Missense_Mutation_p.K441N	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	441							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GATGCAATATTTTTGCATCAA	0.289			NA											16	113					0	0	0.007413	0	0
KLHL18	23276	broad.mit.edu	37	3	47385291	47385291	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:47385291G>T	uc003crd.2	+	10	1711	c.1585G>T	c.(1585-1587)GTT>TTT	p.V529F	KLHL18_uc011bav.1_Missense_Mutation_p.V417F	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	529	Kelch 6.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CCTCTACGCTGTTGGGGGCTA	0.612			NA											17	86					1.15088e-07	1.33751e-07	0.004007	1	0
DAG1	1605	broad.mit.edu	37	3	49568391	49568391	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:49568391C>T	uc003cxc.3	+	3	865	c.447C>T	c.(445-447)TCC>TCT	p.S149S		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	149	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CCCAGACCTCCAGTGTGTTCT	0.602			NA											8	35					0	0	0.00308	0	0
OR5K2	402135	broad.mit.edu	37	3	98217213	98217213	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:98217213C>A	uc011bgx.1	+	1	689	c.689C>A	c.(688-690)TCC>TAC	p.S230Y		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						AGAATGAAATCCAAGGAGGGA	0.343			NA											9	100					0.000442599	0.000467994	0.006214	1	0
KPNA1	3836	broad.mit.edu	37	3	122168504	122168504	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:122168504G>A	uc003efd.1	-	9	870	c.834C>T	c.(832-834)CTC>CTT	p.L278L	KPNA1_uc003efb.1_Silent_p.L77L|KPNA1_uc003efc.1_Silent_p.L77L|KPNA1_uc011bjr.1_Silent_p.L77L|KPNA1_uc010hrh.2_Silent_p.L77L|KPNA1_uc003efe.2_Silent_p.L278L	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	278	Binding to RAG1.|ARM 5.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		ATAGATATGAGAGGGCCCAGC	0.438	Melanoma(12;340 801 11196 19797)		NA											4	60					0	0	0.009096	0	0
KALRN	8997	broad.mit.edu	37	3	124281895	124281895	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:124281895G>C	uc003ehg.2	+	34	5262	c.5135G>C	c.(5134-5136)CGA>CCA	p.R1712P	KALRN_uc003ehi.2_Missense_Mutation_p.R85P	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1712					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TCACACTCCCGAAGCAGCGTG	0.647			NA											10	65					0	0	0.008291	0	0
RUVBL1	8607	broad.mit.edu	37	3	127816180	127816180	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:127816180C>T	uc003ekh.2	-	8	1083	c.979G>A	c.(979-981)GTC>ATC	p.V327I	RUVBL1_uc003eke.2_Missense_Mutation_p.V68I|RUVBL1_uc003ekf.2_Missense_Mutation_p.V267I|RUVBL1_uc010hss.2_Missense_Mutation_p.V327I	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	327					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		GCAAAGATGACGATGGGAGCG	0.542			NA											8	26					0	0	0.00308	0	0
MCCC1	56922	broad.mit.edu	37	3	182743552	182743552	+	Silent	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr3:182743552A>G	uc003fle.2	-	15	1859	c.1722T>C	c.(1720-1722)TAT>TAC	p.Y574Y	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_Intron|MCCC1_uc003flf.2_Silent_p.Y457Y|MCCC1_uc003flg.2_Silent_p.Y465Y|MCCC1_uc011bqp.1_Silent_p.Y527Y	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	574					biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CCTGCATGCTATAAGACCCAT	0.368			NA											6	69					0	0	0.001984	0	0
ADD1	118	broad.mit.edu	37	4	2886264	2886264	+	Silent	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:2886264G>C	uc003gfr.2	+	4	569	c.381G>C	c.(379-381)GTG>GTC	p.V127V	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Silent_p.V127V|ADD1_uc003gfo.2_Silent_p.V127V|ADD1_uc003gfp.2_Silent_p.V127V|ADD1_uc003gfq.2_Silent_p.V127V|ADD1_uc003gfs.2_Silent_p.V127V|ADD1_uc003gft.3_Silent_p.V127V|ADD1_uc003gfu.2_5'Flank	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	127					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGACTCCTGTGAACGATCTTA	0.284	Esophageal Squamous(71;505 1201 20414 34538 37449)		NA											9	197					0	0	0.006214	0	0
EPHA5	2044	broad.mit.edu	37	4	66270177	66270177	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:66270177G>T	uc003hcy.2	-	8	1898	c.1705C>A	c.(1705-1707)CAA>AAA	p.Q569K	EPHA5_uc003hcx.2_Missense_Mutation_p.Q501K|EPHA5_uc003hcz.2_Missense_Mutation_p.Q569K|EPHA5_uc011cah.1_Missense_Mutation_p.Q570K|EPHA5_uc011cai.1_Missense_Mutation_p.Q570K|EPHA5_uc003hda.2_Missense_Mutation_p.Q570K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	569	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						ATCTGGCTTTGATCGCTGGAT	0.438			NA								TSP Lung(17;0.13)			10	48					6.40141e-05	6.99815e-05	0.010729	1	0
FRAS1	80144	broad.mit.edu	37	4	79460483	79460483	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:79460483C>T	uc003hlb.2	+	73	11774	c.11334C>T	c.(11332-11334)TTC>TTT	p.F3778F		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3773	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATAAGTACTTCCATGATGTGC	0.423			NA											4	105					0	0	0.009096	0	0
MMRN1	22915	broad.mit.edu	37	4	90856622	90856622	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:90856622C>T	uc003hst.2	+	6	1862	c.1791C>T	c.(1789-1791)TCC>TCT	p.S597S	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.S339S	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	597	Potential.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ACATGTTATCCAAATGCAGAA	0.348			NA											7	76					0	0	0.001984	0	0
TACR3	6870	broad.mit.edu	37	4	104512727	104512727	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:104512727G>A	uc003hxe.1	-	4	1145	c.1002C>T	c.(1000-1002)ATC>ATT	p.I334I		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	334	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AGACCTGCTGGATGTATTTCC	0.393			NA											17	75					0	0	0.00499	0	0
PDE5A	8654	broad.mit.edu	37	4	120446753	120446753	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr4:120446753C>T	uc003idh.2	-	12	1885	c.1730G>A	c.(1729-1731)CGG>CAG	p.R577Q	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.R535Q|PDE5A_uc003idg.2_Missense_Mutation_p.R525Q|uc003idi.3_Intron	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	577					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AGTAAACATCCGAATTGTACA	0.443			NA											17	73					0	0	0.007413	0	0
BDP1	55814	broad.mit.edu	37	5	70818760	70818760	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:70818760C>T	uc003kbp.1	+	24	5634	c.5371C>T	c.(5371-5373)CTC>TTC	p.L1791F	BDP1_uc003kbo.2_Missense_Mutation_p.L1791F|BDP1_uc003kbq.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1791					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AGAGCAATATCTCAATAAACT	0.303			NA											3	47					0	0	0.004672	0	0
CAST	831	broad.mit.edu	37	5	96011290	96011290	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:96011290G>C	uc003klu.2	+	2	309	c.123G>C	c.(121-123)AAG>AAC	p.K41N	CAST_uc003klt.2_5'UTR|CAST_uc003klv.2_Missense_Mutation_p.K41N|CAST_uc003klw.2_Missense_Mutation_p.K41N|CAST_uc003klx.2_Missense_Mutation_p.K41N|CAST_uc003kly.2_Missense_Mutation_p.K41N|CAST_uc011cuo.1_Missense_Mutation_p.K26N	NM_001750	NP_001741	P20810	ICAL_HUMAN	calpastatin isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		CAGGAGAAAAGAAAGGATCAG	0.338			NA											5	74					0	0	0.001168	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130840380	130840380	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:130840380A>G	uc003kvn.1	-	11	1399	c.1193T>C	c.(1192-1194)ATG>ACG	p.M398T	RAPGEF6_uc003kvp.1_Missense_Mutation_p.M448T|RAPGEF6_uc003kvo.1_Missense_Mutation_p.M398T|RAPGEF6_uc010jdi.1_Missense_Mutation_p.M398T|RAPGEF6_uc010jdj.1_Missense_Mutation_p.M398T|RAPGEF6_uc003kvq.2_Missense_Mutation_p.M115T|RAPGEF6_uc003kvr.2_Missense_Mutation_p.M398T|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.M398T	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	398	cNMP.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CTCATGTACCATAACAATTTC	0.393	Melanoma(168;435 1955 13113 13877 23213)		NA											12	121					0	0	0.020292	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720584	140720584	+	Silent	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:140720584C>A	uc003ljk.1	+	1	2231	c.2046C>A	c.(2044-2046)GCC>GCA	p.A682A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.A682A	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	682	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCCTCCGCCATACCCAACG	0.682			NA											8	190					0.00621372	0.00631157	0.006214	1	0
PCDHGB5	56101	broad.mit.edu	37	5	140778463	140778463	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:140778463C>A	uc003lkf.1	+	1	769	c.769C>A	c.(769-771)CCA>ACA	p.P257T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.P257T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	257	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAACGTGCCACCAGGCACCAC	0.522			NA											16	99					1.3612e-06	1.54031e-06	0.003163	1	0
ADRA1B	147	broad.mit.edu	37	5	159344154	159344154	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr5:159344154A>G	uc003lxt.1	+	1	415	c.242A>G	c.(241-243)AAC>AGC	p.N81S		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	81	Cytoplasmic (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	ACGCCCACCAACTACTTCATT	0.622			NA											8	137					0	0	0.004482	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7988181	7988181	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:7988181A>C	uc003mxx.3	+	1	1847	c.1412A>C	c.(1411-1413)TAC>TCC	p.Y471S	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						TGCATTACTTACCAGCCATTG	0.473			NA											9	39					0	0	0.016723	0	0
GPX6	257202	broad.mit.edu	37	6	28473575	28473575	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:28473575C>A	uc011dlj.1	-	5	414	c.364G>T	c.(364-366)GTG>TTG	p.V122L	GPX6_uc010jrg.1_Intron	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	122					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	CCTGGACACACATACCTGCAG	0.433			NA											7	93					8.12818e-05	8.7378e-05	0.001984	1	0
C6orf47	57827	broad.mit.edu	37	6	31626938	31626938	+	Missense_Mutation	SNP	G	G	A	rs114079572	byFrequency	TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:31626938G>A	uc003nvm.1	-	1	1612	c.787C>T	c.(787-789)CGG>TGG	p.R263W		NM_021184	NP_067007	O95873	CF047_HUMAN	G4 protein	263										ovary(1)	1						TTGGGCTCCCGGAGGCTGACA	0.632			NA											8	156					0	0	0.004482	0	0
COL11A2	1302	broad.mit.edu	37	6	33144245	33144245	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:33144245C>T	uc003ocx.1	-	27	2362	c.2134G>A	c.(2134-2136)GGA>AGA	p.G712R	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.G626R|COL11A2_uc003ocz.1_Missense_Mutation_p.G605R	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	712	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CCTAGAGGTCCCTGAGGTCCA	0.557	Melanoma(1;90 116 3946 5341 17093)		NA											4	38					0	0	0.009096	0	0
KIAA0240	23506	broad.mit.edu	37	6	42832802	42832802	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:42832802G>A	uc003osn.1	+	13	3009	c.2858G>A	c.(2857-2859)AGC>AAC	p.S953N	KIAA0240_uc011duw.1_Missense_Mutation_p.S953N|KIAA0240_uc003osp.1_Missense_Mutation_p.S953N	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	953										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			GGTACTGAGAGCAAACTGTCA	0.512			NA											5	69					0	0	0.001984	0	0
CUL9	23113	broad.mit.edu	37	6	43191089	43191089	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:43191089G>T	uc003ouk.2	+	39	7313	c.7238G>T	c.(7237-7239)CGG>CTG	p.R2413L	CUL9_uc003oul.2_Missense_Mutation_p.R2385L|CUL9_uc010jyk.2_Missense_Mutation_p.R1565L|CUL9_uc003oun.2_Missense_Mutation_p.R208L	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2413					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GAGCTGCTCCGGCGGATCCAG	0.677			NA											3	6					0.004672	0.00478324	0.004672	1	0
EFHC1	114327	broad.mit.edu	37	6	52288786	52288786	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:52288786G>T	uc003pap.3	+	2	321	c.106G>T	c.(106-108)GGC>TGC	p.G36C	EFHC1_uc011dwv.1_5'UTR|EFHC1_uc011dww.1_Missense_Mutation_p.G17C	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	36						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					CTACAGGAACGGCTATGCAAT	0.463			NA											37	93					6.19805e-25	7.99549e-25	0.005524	1	0
AHI1	54806	broad.mit.edu	37	6	135784313	135784313	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr6:135784313T>C	uc003qgi.2	-	8	1265	c.881A>G	c.(880-882)CAA>CGA	p.Q294R	AHI1_uc003qgh.2_Missense_Mutation_p.Q294R|AHI1_uc003qgj.2_Missense_Mutation_p.Q294R|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.Q294R	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	294						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TGTATCATCTTGCATGCTGTC	0.313			NA											3	45					0	0	0.014758	0	0
BMPER	168667	broad.mit.edu	37	7	34085929	34085929	+	Silent	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:34085929A>T	uc011kap.1	+	7	702	c.588A>T	c.(586-588)ACA>ACT	p.T196T		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	196	VWFC 3.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						GAGGCAGGACACAATGTGTGA	0.438			NA											17	128					0	0	0.00499	0	0
ZNF735	730291	broad.mit.edu	37	7	63680605	63680605	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:63680605G>A	uc011kdn.1	+	4	1176	c.1176G>A	c.(1174-1176)TGG>TGA	p.W392*		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	392	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTTAAGTGGCATTCAAGTC	0.373			NA											3	17					0	0	0.004672	0	0
PCLO	27445	broad.mit.edu	37	7	82585054	82585054	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:82585054C>T	uc003uhx.2	-	5	5504	c.5215G>A	c.(5215-5217)GAG>AAG	p.E1739K	PCLO_uc003uhv.2_Missense_Mutation_p.E1739K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1670					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCACTGTCCTCATCAAGTGAT	0.498			NA											12	157					0	0	0.010729	0	0
STEAP1	26872	broad.mit.edu	37	7	89790341	89790341	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:89790341C>G	uc003ujx.2	+	3	507	c.307C>G	c.(307-309)CAA>GAA	p.Q103E	STEAP1_uc010lem.2_Missense_Mutation_p.Q103E	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	103					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					AACTTCCCATCAACAATATTT	0.393			NA											8	85					0	0	0.00308	0	0
STAG3	10734	broad.mit.edu	37	7	99798718	99798718	+	Silent	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:99798718C>A	uc003utx.1	+	20	2222	c.2067C>A	c.(2065-2067)TCC>TCA	p.S689S	STAG3_uc010lgs.1_Silent_p.S477S|STAG3_uc011kjk.1_Silent_p.S631S|GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc003uua.3_3'UTR|GATS_uc010lgt.2_RNA|STAG3_uc003uub.1_5'UTR	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	689					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCAGTCGTCCTTCCTAGATG	0.517			NA											10	48					6.40141e-05	6.99815e-05	0.010729	1	0
CUX1	1523	broad.mit.edu	37	7	101833099	101833099	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:101833099G>T	uc003uyx.3	+	12	1062	c.1024G>T	c.(1024-1026)GAA>TAA	p.E342*	CUX1_uc003uys.3_Nonsense_Mutation_p.E353*|CUX1_uc003uyt.2_Nonsense_Mutation_p.E353*|CUX1_uc011kkn.1_Nonsense_Mutation_p.E314*|CUX1_uc003uyw.2_Nonsense_Mutation_p.E307*|CUX1_uc003uyv.2_Nonsense_Mutation_p.E337*|CUX1_uc003uyu.2_Nonsense_Mutation_p.E351*	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	342	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						TCAGCAACTGGAAGAAAAACT	0.537			NA											10	35					3.07112e-06	3.44499e-06	0.010729	1	0
TRPV5	56302	broad.mit.edu	37	7	142625896	142625896	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:142625896G>T	uc003wby.1	-	6	916	c.652C>A	c.(652-654)CTG>ATG	p.L218M	TRPV5_uc003wbz.2_Missense_Mutation_p.L218M	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	218	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GACAGCAGCAGGTTGTACATC	0.582			NA											13	74					4.36969e-10	5.36848e-10	0.016723	1	0
MLL3	58508	broad.mit.edu	37	7	151944996	151944996	+	Silent	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:151944996C>G	uc003wla.2	-	14	2742	c.2523G>C	c.(2521-2523)CGG>CGC	p.R841R		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	841					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCTGTTTGGACCGAGGTCTAC	0.378	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								7	290					0	0	0.001984	0	0
CSMD1	64478	broad.mit.edu	37	8	2944663	2944663	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr8:2944663G>C	uc011kwk.1	-	49	7823	c.7433C>G	c.(7432-7434)CCA>CGA	p.P2478R	CSMD1_uc011kwj.1_Missense_Mutation_p.P1807R|CSMD1_uc010lrg.2_Missense_Mutation_p.P546R	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2478	Sushi 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CATGCCAAGTGGGTTTCGTCT	0.498			NA											7	60					0	0	0.001984	0	0
CSMD3	114788	broad.mit.edu	37	8	113314076	113314076	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr8:113314076C>G	uc003ynu.2	-	53	8545	c.8386G>C	c.(8386-8388)GTA>CTA	p.V2796L	CSMD3_uc003yns.2_Missense_Mutation_p.V1998L|CSMD3_uc003ynt.2_Missense_Mutation_p.V2756L|CSMD3_uc011lhx.1_Missense_Mutation_p.V2627L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2796	Extracellular (Potential).|Sushi 17.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATTCCCTTACAGCAGAGCCC	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	79					0	0	0.016723	0	0
EFR3A	23167	broad.mit.edu	37	8	132998476	132998476	+	Silent	SNP	T	T	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr8:132998476T>C	uc003yte.2	+	17	2106	c.1905T>C	c.(1903-1905)TTT>TTC	p.F635F		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	635						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			CCCCTTATTTTCTACCAGAGC	0.313			NA											4	27					0	0	0.001168	0	0
KANK1	23189	broad.mit.edu	37	9	730172	730172	+	Silent	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:730172G>A	uc003zgl.1	+	8	3469	c.2820G>A	c.(2818-2820)CTG>CTA	p.L940L	KANK1_uc003zgm.2_Silent_p.L940L|KANK1_uc003zgn.1_Silent_p.L940L|KANK1_uc003zgs.1_Silent_p.L782L|KANK1_uc010mgx.1_5'Flank|KANK1_uc010mgy.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	940					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TCAGCAGCCTGGATGCCTTCC	0.552			NA											4	47					0	0	0.009096	0	0
PLAA	9373	broad.mit.edu	37	9	26926558	26926558	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:26926558C>A	uc003zqd.2	-	5	991	c.566G>T	c.(565-567)GGG>GTG	p.G189V	PLAA_uc003zqe.2_Missense_Mutation_p.G189V	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	189					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		GTCTTCATGCCCTGCATTAAA	0.338	Melanoma(175;2670 2735 14091 35526)		NA											8	50					1.06961e-07	1.25436e-07	0.00308	1	0
KIF27	55582	broad.mit.edu	37	9	86504081	86504081	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:86504081C>G	uc004ana.2	-	7	2041	c.1897G>C	c.(1897-1899)GAA>CAA	p.E633Q	KIF27_uc010mpw.2_Missense_Mutation_p.E633Q|KIF27_uc010mpx.2_Missense_Mutation_p.E633Q	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	633					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TTATCTTGTTCTTCTATGTGA	0.413			NA											10	161					0	0	0.006214	0	0
ATP6V1G1	9550	broad.mit.edu	37	9	117359867	117359867	+	Silent	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr9:117359867C>T	uc004bjc.2	+	3	326	c.201C>T	c.(199-201)GGC>GGT	p.G67G		NM_004888	NP_004879	O75348	VATG1_HUMAN	vacuolar H+ ATPase G1	67					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances				0						GATCCCGTGGCAGTTGCAGCA	0.512			NA											7	65					0	0	0.001984	0	0
ZFX	7543	broad.mit.edu	37	X	24228777	24228777	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:24228777A>T	uc004dbf.2	+	9	1960	c.1702A>T	c.(1702-1704)AGA>TGA	p.R568*	ZFX_uc004dbe.2_3'UTR|ZFX_uc011mjv.1_Nonsense_Mutation_p.R607*|ZFX_uc010nfz.2_Nonsense_Mutation_p.R224*	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	568	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						AAAGCACATGAGAATCCATAC	0.458	Esophageal Squamous(20;306 562 7346 32868 37983)		NA											15	63					0	0	0.00499	0	0
ITIH5L	347365	broad.mit.edu	37	X	54785155	54785155	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:54785155C>A	uc004dtj.2	-	8	1382	c.1352G>T	c.(1351-1353)CGC>CTC	p.R451L		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	451	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CTCATATATGCGCCGGGCTAT	0.577			NA											4	11					0.00909568	0.00916674	0.009096	1	0
MORC4	79710	broad.mit.edu	37	X	106198242	106198242	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:106198242C>T	uc004emu.3	-	14	1829	c.1586G>A	c.(1585-1587)GGA>GAA	p.G529E	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.G529E|MORC4_uc004emw.3_Missense_Mutation_p.G277E	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	529							ATP binding|zinc ion binding			ovary(1)	1						GCTATGAATTCCCTCATATCC	0.393			NA											26	63					0	0	0.01892	0	0
DOCK11	139818	broad.mit.edu	37	X	117712548	117712548	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chrX:117712548G>A	uc004eqp.2	+	13	1513	c.1450G>A	c.(1450-1452)GTA>ATA	p.V484I	DOCK11_uc004eqq.2_Missense_Mutation_p.V250I	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	484					blood coagulation	cytosol	GTP binding			ovary(3)	3						AATTGAAAAGGTACTACAGGG	0.348			NA											4	53					0	0	0.009096	0	0
ARNT	405	broad.mit.edu	37	1	150789322	150789326	+	Frame_Shift_Del	DEL	GTTGG	GTTGG	-			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	GTTGG	GTTGG	-	-	GTTGG	GTTGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr1:150789322_150789326delGTTGG	uc001evr.1	-	18	1883_1887	c.1740_1744delCCAAC	c.(1738-1746)ACCCAACAGfs	p.T580fs	ARNT_uc010pck.1_Frame_Shift_Del_p.T69fs|ARNT_uc001evs.1_Frame_Shift_Del_p.T565fs|ARNT_uc009wmb.1_Frame_Shift_Del_p.T566fs|ARNT_uc009wmc.1_Frame_Shift_Del_p.T580fs|ARNT_uc009wmd.1_Frame_Shift_Del_p.T565fs	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	580_582					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGAATAGCTGTTGGGTGGCAGGGA	0.556			NA	T	ETV6	AML								18	87	---	---	---	---	NA	NA	NA	NA	NA
STK31	56164	broad.mit.edu	37	7	23775275	23775275	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:23775275delA	uc003sws.3	+	7	669	c.602delA	c.(601-603)GAAfs	p.E201fs	STK31_uc003swt.3_Frame_Shift_Del_p.E178fs|STK31_uc011jze.1_Frame_Shift_Del_p.E201fs|STK31_uc010kuq.2_Frame_Shift_Del_p.E178fs	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	201							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						GATATAGGGGAAGAGGTGCTT	0.398			NA											23	116	---	---	---	---	NA	NA	NA	NA	NA
GRB10	2887	broad.mit.edu	37	7	50737429	50737430	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7162-01A-21D-2063-08	TCGA-78-7162-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ac2c5bb2-ead3-4bd7-b0e5-d9eae2dc0577	d600b5f9-7e31-43c9-99f6-4909c035211c	g.chr7:50737429_50737430insC	uc003tpi.2	-	4	524_525	c.493_494insG	c.(493-495)GCCfs	p.A165fs	GRB10_uc003tph.3_Frame_Shift_Ins_p.A107fs|GRB10_uc003tpj.2_Frame_Shift_Ins_p.A165fs|GRB10_uc003tpk.2_Frame_Shift_Ins_p.A165fs|GRB10_uc010kzb.2_Frame_Shift_Ins_p.A107fs|GRB10_uc003tpl.2_Frame_Shift_Ins_p.A159fs|GRB10_uc003tpm.2_Frame_Shift_Ins_p.A107fs|GRB10_uc003tpn.2_Frame_Shift_Ins_p.A107fs	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	165					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					CTGCTTTGCGGCGGCCTGGCTC	0.584			NA							Russell-Silver_syndrome				7	30	---	---	---	---	NA	NA	NA	NA	NA