Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNFRSF14	8764	broad.mit.edu	37	1	2493144	2493144	+	Missense_Mutation	SNP	G	G	T	rs147648888		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:2493144G>T	uc001ajr.2	+	6	883	c.584G>T	c.(583-585)GGG>GTG	p.G195V	TNFRSF14_uc001ajt.1_3'UTR|TNFRSF14_uc001ajs.2_Intron	NM_003820	NP_003811	Q92956	TNR14_HUMAN	tumor necrosis factor receptor superfamily,	195	Extracellular (Potential).				immune response|interspecies interaction between organisms|T cell costimulation		tumor necrosis factor receptor activity			kidney(1)	1	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;1.11e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000326)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		GCCGGAGCTGGGACCAGCAGC	0.597			NA	Mis|N|F		follicular lymphoma								23	50					9.04412e-07	1.26618e-06	0.004656	1	0
RNF207	388591	broad.mit.edu	37	1	6269998	6269998	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:6269998G>A	uc001amg.2	+	8	942	c.768G>A	c.(766-768)GAG>GAA	p.E256E	RNF207_uc001amh.2_Missense_Mutation_p.E145K|RNF207_uc010nzp.1_RNA	NM_207396	NP_997279	Q6ZRF8	RN207_HUMAN	ring finger protein 207	256						intracellular	zinc ion binding				0	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		GGCTGGCAGAGAGGAAAGCGC	0.662			NA											25	30					0	0	0.005443	0	0
ESPN	83715	broad.mit.edu	37	1	6511766	6511766	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:6511766G>A	uc001amy.2	+	9	2187	c.2019G>A	c.(2017-2019)GGG>GGA	p.G673G	ESPN_uc001amz.2_Silent_p.G107G	NM_031475	NP_113663	B1AK53	ESPN_HUMAN	espin	673	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding				0	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		AGAGCAAGGGGCTGACCACAG	0.657			NA											7	17					0	0	0.001984	0	0
PADI2	11240	broad.mit.edu	37	1	17413136	17413136	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:17413136C>A	uc001baf.2	-	7	796	c.714G>T	c.(712-714)GTG>GTT	p.V238V	PADI2_uc010ocm.1_Missense_Mutation_p.W157L|PADI2_uc001bag.1_Silent_p.V238V	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	238					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TGTACTTGACCACATGGTAGA	0.607			NA											25	18					2.48779e-11	3.93696e-11	0.005443	1	0
UBR4	23352	broad.mit.edu	37	1	19454761	19454761	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:19454761C>A	uc001bbi.2	-	62	9059	c.9055G>T	c.(9055-9057)GGG>TGG	p.G3019W	UBR4_uc001bbk.1_Missense_Mutation_p.G666W	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3019					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCTAGGGCCCCCTTGTCTTTC	0.433			NA											52	21					5.73376e-24	1.10637e-23	0.00361	1	0
UBR4	23352	broad.mit.edu	37	1	19497254	19497254	+	Splice_Site	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:19497254A>T	uc001bbi.2	-	26	3647	c.3643_splice	c.e26+1	p.G1215_splice	UBR4_uc001bbm.1_Splice_Site_p.G426_splice	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTGTTCTCTTACCCAGAGTAT	0.418			NA											17	37					0	0	0.004007	0	0
FAM76A	199870	broad.mit.edu	37	1	28087051	28087051	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:28087051A>T	uc001boq.2	+	9	985	c.883A>T	c.(883-885)AGC>TGC	p.S295C	FAM76A_uc001bor.2_Missense_Mutation_p.S329C|FAM76A_uc001bos.2_Missense_Mutation_p.S300C|FAM76A_uc001bot.2_Missense_Mutation_p.S266C|FAM76A_uc010ofm.1_Missense_Mutation_p.S215C	NM_152660	NP_689873	Q8TAV0	FA76A_HUMAN	hypothetical protein LOC199870 isoform 3	295	Potential.										0		Colorectal(325;0.000147)|all_lung(284;0.00181)|Lung NSC(340;0.00278)|Renal(390;0.00357)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00253)|KIRC - Kidney renal clear cell carcinoma(1967;0.00292)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)		TTTGTCCAAGAGCAAGAAGTC	0.458			NA											7	12					0	0	0.001984	0	0
GJB4	127534	broad.mit.edu	37	1	35227444	35227444	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:35227444T>C	uc001bxv.1	+	2	959	c.589T>C	c.(589-591)TGC>CGC	p.C197R	GJB4_uc001bxw.3_Missense_Mutation_p.C197R	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	197	Helical; (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AGCTGCCATCTGCATCCTGCT	0.607			NA											24	12					0	0	0.005443	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35916033	35916033	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:35916033C>T	uc001byx.2	-	14	2398	c.2140G>A	c.(2140-2142)GGC>AGC	p.G714S	KIAA0319L_uc001byw.2_Missense_Mutation_p.G156S|KIAA0319L_uc010ohv.1_Missense_Mutation_p.G356S	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	714	PKD 5.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GACTTAGAGCCATCCAGCTCT	0.488			NA											5	59					0	0	0.000602	0	0
SF3A3	10946	broad.mit.edu	37	1	38447413	38447413	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:38447413G>C	uc001cci.2	-	7	663	c.539C>G	c.(538-540)GCA>GGA	p.A180G	SF3A3_uc010oik.1_Missense_Mutation_p.A127G	NM_006802	NP_006793	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3	180					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CTTATACTCTGCATTCTTCCT	0.353			NA											41	15					0	0	0.00874	0	0
MACF1	23499	broad.mit.edu	37	1	39888078	39888078	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:39888078G>A	uc010oiu.1	+	23	11300	c.11169G>A	c.(11167-11169)CAG>CAA	p.Q3723Q	MACF1_uc010ois.1_Silent_p.Q3221Q|MACF1_uc001cda.1_Silent_p.Q3108Q|MACF1_uc001cdc.1_Silent_p.Q2287Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5288	Spectrin 6.|LRR 21.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATCCTCTTCAGATGAAATTGC	0.398			NA											35	20					0	0	0.003755	0	0
TMCO2	127391	broad.mit.edu	37	1	40713763	40713763	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:40713763C>T	uc001cfe.2	+	1	191	c.98C>T	c.(97-99)ACT>ATT	p.T33I		NM_001008740	NP_001008740	Q7Z6W1	TMCO2_HUMAN	transmembrane and coiled-coil domains 2	33						integral to membrane				ovary(1)	1	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			TTGGGAGAGACTAGTGCACCT	0.398			NA											39	117					0	0	0.005524	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46120352	46120352	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:46120352T>A	uc001coq.2	-	6	1701	c.340A>T	c.(340-342)ACA>TCA	p.T114S		NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGGTTCCCTGTGCCACCTCCA	0.512			NA											33	16					0	0	0.003271	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52698947	52698947	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:52698947A>T	uc001cto.2	+	3	241	c.69A>T	c.(67-69)GAA>GAT	p.E23D	ZFYVE9_uc001ctn.2_Missense_Mutation_p.E23D|ZFYVE9_uc001ctp.2_Missense_Mutation_p.E23D	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	23					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						AACAAAACGAAGGTGAGAATT	0.363			NA											22	8					0	0	0.00333	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704586	52704586	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:52704586A>G	uc001cto.2	+	4	1669	c.1497A>G	c.(1495-1497)GAA>GAG	p.E499E	ZFYVE9_uc001ctn.2_Silent_p.E499E|ZFYVE9_uc001ctp.2_Silent_p.E499E	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	499					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						CCTCCAAAGAAGATTCAGTAA	0.393			NA											3	59					0	0	0.004672	0	0
CC2D1B	200014	broad.mit.edu	37	1	52823548	52823548	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:52823548G>C	uc001ctq.1	-	14	1640	c.1502C>G	c.(1501-1503)CCA>CGA	p.P501R	CC2D1B_uc001ctr.2_Missense_Mutation_p.P41R|CC2D1B_uc001cts.2_Missense_Mutation_p.P186R	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	501										ovary(2)	2						CTTGGCCACTGGGGCCTGTGC	0.587			NA											27	6					0	0	0.007291	0	0
C8A	731	broad.mit.edu	37	1	57320623	57320623	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:57320623G>T	uc001cyo.2	+	1	181	c.49G>T	c.(49-51)GGG>TGG	p.G17W		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	17					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TTGTCAGCCTGGGGTAACTGC	0.443			NA											15	3					4.75885e-15	8.12053e-15	0.00499	1	0
DAB1	1600	broad.mit.edu	37	1	57480922	57480922	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:57480922G>T	uc001cys.1	-	14	1752	c.1078C>A	c.(1078-1080)CAG>AAG	p.Q360K	DAB1_uc001cyt.1_Missense_Mutation_p.Q358K|DAB1_uc001cyq.1_Missense_Mutation_p.Q358K|DAB1_uc001cyr.1_Missense_Mutation_p.Q274K|DAB1_uc009vzw.1_Missense_Mutation_p.Q342K|DAB1_uc009vzx.1_Missense_Mutation_p.Q360K	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	393					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GGCGGAAACTGCCCGGCCACA	0.657			NA											21	46					1.55469e-16	2.75083e-16	0.00333	1	0
MIER1	57708	broad.mit.edu	37	1	67442278	67442278	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:67442278G>T	uc001dde.2	+	12	1236	c.1102G>T	c.(1102-1104)GTC>TTC	p.V368F	MIER1_uc010opf.1_Missense_Mutation_p.V332F|MIER1_uc009way.2_Missense_Mutation_p.V332F|MIER1_uc001ddc.2_Missense_Mutation_p.V368F|MIER1_uc001ddh.2_Missense_Mutation_p.V252F|MIER1_uc001ddf.2_Missense_Mutation_p.V332F|MIER1_uc001ddg.2_Missense_Mutation_p.V288F|MIER1_uc010opg.1_Missense_Mutation_p.V332F|MIER1_uc001ddj.1_Missense_Mutation_p.V315F|MIER1_uc001ddi.2_Missense_Mutation_p.V315F	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b	339	SANT.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						TTTCTTACAGGTCCGAACAAG	0.333			NA											28	34					3.65163e-15	6.25341e-15	0.00632	1	0
LHX8	431707	broad.mit.edu	37	1	75622645	75622645	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:75622645C>A	uc001dgo.2	+	9	1542	c.878C>A	c.(877-879)CCA>CAA	p.P293Q	LHX8_uc001dgq.2_Missense_Mutation_p.P232Q	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	293						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCCTCCACCCCAGTCACAGCA	0.512			NA											21	109					4.35082e-09	6.52963e-09	0.001523	1	0
RPF1	80135	broad.mit.edu	37	1	84961575	84961575	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:84961575A>G	uc001djv.3	+	7	755	c.710A>G	c.(709-711)AAG>AGG	p.K237R		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	237	Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						AGAAGAGGCAAGGACCCCACA	0.348			NA											13	20					0	0	0.003163	0	0
SYDE2	84144	broad.mit.edu	37	1	85648430	85648430	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:85648430T>A	uc009wcm.2	-	3	1944	c.1895A>T	c.(1894-1896)AAA>ATA	p.K632I	SYDE2_uc001dku.3_Missense_Mutation_p.K632I	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	632					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		TTTGCTAGCTTTAGTTGTAAG	0.363			NA											11	38					0	0	0.008291	0	0
CLCA4	22802	broad.mit.edu	37	1	87041235	87041235	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:87041235C>A	uc009wcs.2	+	11	1948	c.1904C>A	c.(1903-1905)TCA>TAA	p.S635*	CLCA4_uc009wct.2_Nonsense_Mutation_p.S398*|CLCA4_uc009wcu.2_Nonsense_Mutation_p.S455*	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	635						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTCATTGAATCACAGAATGGA	0.378			NA											59	61					5.73376e-24	1.10637e-23	0.00361	1	0
TGFBR3	7049	broad.mit.edu	37	1	92161253	92161253	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:92161253A>G	uc001doh.2	-	16	2879	c.2413T>C	c.(2413-2415)TTG>CTG	p.L805L	TGFBR3_uc009wde.2_Silent_p.L500L|TGFBR3_uc010osy.1_Silent_p.L763L|TGFBR3_uc001doi.2_Silent_p.L804L|TGFBR3_uc001doj.2_Silent_p.L804L	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	805	Helical; (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		ATGTACCACAAGGCCCCCGTC	0.478			NA											19	59					0	0	0.001882	0	0
TGFBR3	7049	broad.mit.edu	37	1	92193305	92193306	+	Missense_Mutation	DNP	CC	CC	GT			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:92193305_92193306CC>GT	uc001doh.2	-	7	1261_1262	c.795_796GG>AC	c.(793-798)GTGGTC>GTACTC	p.V266L	TGFBR3_uc009wde.2_Missense_Mutation_p.V44L|TGFBR3_uc010osy.1_Missense_Mutation_p.V224L|TGFBR3_uc001doi.2_Missense_Mutation_p.V266L|TGFBR3_uc001doj.2_Missense_Mutation_p.V266L	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	266	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		AGATTTTTGACCACTTCAAGAT	0.386			NA											21	47					0	0	0.004672	0	0
ABCA4	24	broad.mit.edu	37	1	94506797	94506797	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:94506797T>C	uc001dqh.2	-	23	3594	c.3490A>G	c.(3490-3492)AAA>GAA	p.K1164E		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1164	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TGGATGTTTTTCATCTTGCGC	0.567			NA											14	56					0	0	0.00245	0	0
DPYD	1806	broad.mit.edu	37	1	97700500	97700500	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:97700500C>A	uc001drv.2	-	19	2487	c.2350G>T	c.(2350-2352)GCT>TCT	p.A784S		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	784					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CCAGGCAGAGCACGAGCAATG	0.463			NA											18	15					0.000566183	0.000727841	0.00499	1	0
S1PR1	1901	broad.mit.edu	37	1	101705298	101705298	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:101705298C>T	uc001dud.2	+	2	1272	c.758C>T	c.(757-759)GCG>GTG	p.A253V	S1PR1_uc009weg.2_Missense_Mutation_p.A253V	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	253	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						AAGTCGCTGGCGCTGCTCAAG	0.587			NA											55	42					0	0	0.00361	0	0
VAV3	10451	broad.mit.edu	37	1	108116723	108116723	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:108116723C>T	uc001dvk.1	-	26	2502	c.2448G>A	c.(2446-2448)AAG>AAA	p.K816K	VAV3_uc010ouu.1_Silent_p.K248K|VAV3_uc001dvj.1_Silent_p.K256K|VAV3_uc010ouv.1_Silent_p.K220K|VAV3_uc010ouw.1_Silent_p.K844K	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	816	SH3 2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTGTGTAAATCTTCACCACAT	0.478			NA											81	143					0	0	0.00361	0	0
AKNAD1	254268	broad.mit.edu	37	1	109377570	109377570	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:109377570A>G	uc001dwa.2	-	8	1914	c.1645T>C	c.(1645-1647)TGT>CGT	p.C549R	AKNAD1_uc010ovb.1_Missense_Mutation_p.C256R|AKNAD1_uc001dwb.2_Intron	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	549										ovary(3)	3						GCCAGCTCACAGAGCTCCTCG	0.667			NA											12	68					0	0	0.000978	0	0
AKNAD1	254268	broad.mit.edu	37	1	109385883	109385883	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:109385883C>T	uc001dwa.2	-	6	1521	c.1252G>A	c.(1252-1254)GAG>AAG	p.E418K	AKNAD1_uc010ovb.1_Missense_Mutation_p.E125K|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	418	Potential.									ovary(3)	3						TGCAGTTTCTCCAGGACCTGC	0.493			NA											31	34					0	0	0.003755	0	0
CLCC1	23155	broad.mit.edu	37	1	109493041	109493041	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:109493041G>A	uc001dwe.1	-	2	111	c.19C>T	c.(19-21)CTT>TTT	p.L7F	AKNAD1_uc010ovb.1_Intron|CLCC1_uc001dwf.1_Missense_Mutation_p.L7F|CLCC1_uc001dwg.1_Missense_Mutation_p.L7F|CLCC1_uc009wes.1_Missense_Mutation_p.L7F|CLCC1_uc009wet.1_Missense_Mutation_p.L7F|CLCC1_uc001dwh.1_Missense_Mutation_p.L7F	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Mid-1-related chloride channel 1 isoform 1	7						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				liver(1)	1		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CATTCACAAAGGAGCAAAGAA	0.328			NA											29	43					0	0	0.007291	0	0
WDR77	79084	broad.mit.edu	37	1	111983962	111983962	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:111983962G>A	uc001ebb.2	-	10	958	c.919C>T	c.(919-921)CCG>TCG	p.P307S	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Missense_Mutation_p.P243S	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	307					ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGATTGAGCGGGGACCAAGTC	0.542			NA											39	53					0	0	0.00874	0	0
KCND3	3752	broad.mit.edu	37	1	112524607	112524607	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:112524607C>G	uc001ebu.1	-	2	1222	c.742G>C	c.(742-744)GCT>CCT	p.A248P	KCND3_uc001ebv.1_Missense_Mutation_p.A248P	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	248	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CGGCTGGGAGCCGCGAAGAGC	0.622			NA											22	35					0	0	0.002299	0	0
MAGI3	260425	broad.mit.edu	37	1	114186388	114186388	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:114186388G>T	uc001edk.2	+	11	2171	c.1990G>T	c.(1990-1992)GCC>TCC	p.A664S	MAGI3_uc001edh.3_Missense_Mutation_p.A689S|MAGI3_uc001edi.3_Missense_Mutation_p.A664S|MAGI3_uc010owm.1_Missense_Mutation_p.A689S|MAGI3_uc001edj.2_Missense_Mutation_p.A385S	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	689					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AACCAAAACTGCCAAAATGGT	0.413			NA											33	63					3.62531e-18	6.5971e-18	0.004289	1	0
SPAG17	200162	broad.mit.edu	37	1	118535194	118535194	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:118535194G>T	uc001ehk.2	-	36	5324	c.5256C>A	c.(5254-5256)GCC>GCA	p.A1752A		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1752						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TGGCACCCGGGGCACTCACTA	0.468			NA											32	43					3.80469e-20	7.14032e-20	0.001786	1	0
HAO2	51179	broad.mit.edu	37	1	119927430	119927430	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:119927430C>A	uc001ehq.1	+	5	667	c.315C>A	c.(313-315)ACC>ACA	p.T105T	HAO2_uc001ehr.1_Silent_p.T105T	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	105	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GCTACATCACCAGCACATTTG	0.547			NA											37	54					3.21399e-22	6.13988e-22	0.004878	1	0
HRNR	388697	broad.mit.edu	37	1	152187476	152187476	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:152187476C>G	uc001ezt.1	-	3	6705	c.6629G>C	c.(6628-6630)AGC>ACC	p.S2210T		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2210	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGGCCACGGCTGGAAGAACG	0.597			NA											26	308					0	0	0.001786	0	0
FLG	2312	broad.mit.edu	37	1	152278628	152278628	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:152278628A>C	uc001ezu.1	-	3	8770	c.8734T>G	c.(8734-8736)TCC>GCC	p.S2912A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2912	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTTTCTGGAAGCAGACCCA	0.567			NA							Ichthyosis				43	304					0	0	0.00361	0	0
FLG	2312	broad.mit.edu	37	1	152283392	152283392	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:152283392C>T	uc001ezu.1	-	3	4006	c.3970G>A	c.(3970-3972)GAC>AAC	p.D1324N	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1324	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAGCTGTCTGCAGAGTGC	0.358			NA							Ichthyosis				195	219					0	0	0.00361	0	0
CRNN	49860	broad.mit.edu	37	1	152384655	152384655	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:152384655C>G	uc001ezx.2	-	2	129	c.55G>C	c.(55-57)GCA>CCA	p.A19P		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	19					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCGTCCTTGCATAGCGCCTG	0.522			NA											60	91					0	0	0.00361	0	0
NUP210L	91181	broad.mit.edu	37	1	154062039	154062039	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:154062039C>A	uc001fdw.2	-	16	2291	c.2219G>T	c.(2218-2220)GGT>GTT	p.G740V	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.G740V	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	740						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			GTTCAGGACACCTGGATGATT	0.448			NA											51	69					1.22102e-19	2.26929e-19	0.00361	1	0
FDPS	2224	broad.mit.edu	37	1	155287752	155287752	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:155287752G>A	uc001fkc.2	+	5	720	c.501G>A	c.(499-501)GTG>GTA	p.V167V	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Silent_p.V101V|FDPS_uc001fke.2_Silent_p.V167V|FDPS_uc001fkf.2_Silent_p.V101V|C1orf104_uc001fkh.1_RNA|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	167					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	TCTTCCTGGTGGCAGATGACA	0.493			NA											7	61					0	0	0.00308	0	0
CD5L	922	broad.mit.edu	37	1	157803090	157803090	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:157803090C>A	uc001frk.3	-	5	1074	c.931G>T	c.(931-933)GAT>TAT	p.D311Y		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	311	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CGAACATTATCCAGCCAGATG	0.582			NA											48	58					4.64027e-19	8.55772e-19	0.00361	1	0
CD1C	911	broad.mit.edu	37	1	158263089	158263089	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:158263089A>C	uc001fru.2	+	5	1269	c.977A>C	c.(976-978)CAC>CCC	p.H326P	CD1C_uc001frv.2_Intron	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	326	Cytoplasmic (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					TTTAAGAAGCACTGGTGAGTT	0.398			NA											45	167					0	0	0.00361	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517333	158517333	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:158517333G>T	uc010pil.1	-	1	563	c.563C>A	c.(562-564)CCA>CAA	p.P188Q		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GTTAAGGAGTGGAGAGATATC	0.458			NA											19	26					1.45105e-14	2.44562e-14	0.006122	1	0
OR10J5	127385	broad.mit.edu	37	1	159505076	159505076	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:159505076A>T	uc010piw.1	-	1	722	c.722T>A	c.(721-723)GTC>GAC	p.V241D		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					GAGGTGGGAGACACAGGTGGC	0.488			NA											29	51					0	0	0.007291	0	0
DDR2	4921	broad.mit.edu	37	1	162745580	162745580	+	Silent	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:162745580T>C	uc001gcf.2	+	16	2460	c.1995T>C	c.(1993-1995)TTT>TTC	p.F665F	DDR2_uc001gcg.2_Silent_p.F665F	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	665	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCAATCAGTTTCTTTCCCGCC	0.473	NSCLC(161;314 2006 8283 19651 23192)		NA											39	164					0	0	0.002522	0	0
RXRG	6258	broad.mit.edu	37	1	165376069	165376069	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:165376069C>G	uc001gda.2	-	9	1524	c.1224G>C	c.(1222-1224)AAG>AAC	p.K408N		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	408	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GTTCCGGATACTTCTGCTTGG	0.458			NA											38	39					0	0	0.006999	0	0
DUSP27	92235	broad.mit.edu	37	1	167097711	167097711	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:167097711G>T	uc001geb.1	+	5	3343	c.3343G>T	c.(3343-3345)GGA>TGA	p.G1115*		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1115					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GTTTGCATCTGGACGGCGGTC	0.507			NA											19	22					1.96292e-10	3.0411e-10	0.001523	1	0
MYOC	4653	broad.mit.edu	37	1	171621301	171621301	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:171621301C>A	uc001ghu.2	-	1	473	c.451G>T	c.(451-453)GTT>TTT	p.V151F	MYOC_uc010pmk.1_Missense_Mutation_p.V93F	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	151	Potential.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TCCTCCAGAACTGACTTGTCT	0.577			NA											101	144					1.41219e-46	3.04334e-46	0.00361	1	0
FASLG	356	broad.mit.edu	37	1	172635156	172635156	+	Nonstop_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:172635156A>C	uc001gis.2	+	4	1003	c.846A>C	c.(844-846)TAA>TAC	p.*282Y	FASLG_uc001git.2_3'UTR	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	282					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						ATAAGCTCTAAGAGAAGCACT	0.388	Ovarian(28;486 876 30334 44033)		NA											12	56					0	0	0.001855	0	0
TNR	7143	broad.mit.edu	37	1	175372638	175372638	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:175372638G>C	uc001gkp.1	-	2	695	c.614C>G	c.(613-615)CCG>CGG	p.P205R	TNR_uc009wwu.1_Missense_Mutation_p.P205R|TNR_uc010pmz.1_Missense_Mutation_p.P205R	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	205	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GCAACCCAGCGGGCAGTAGGG	0.597			NA											58	103					0	0	0.00361	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526293	176526293	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:176526293C>A	uc001gkz.2	+	2	1999	c.835C>A	c.(835-837)CTG>ATG	p.L279M	PAPPA2_uc001gky.1_Missense_Mutation_p.L279M|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	279					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCCAGAAGTGCTGGCTGAGAT	0.582			NA											13	20					7.03913e-09	1.04822e-08	0.001368	1	0
MR1	3140	broad.mit.edu	37	1	181021464	181021464	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:181021464A>G	uc001goq.1	+	4	703	c.698A>G	c.(697-699)TAC>TGC	p.Y233C	MR1_uc001gor.1_Missense_Mutation_p.Y188C|MR1_uc001gos.1_Intron|MR1_uc010pns.1_Intron	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	233	Extracellular (Potential).|Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						CCAGAAATTTACATGACATGG	0.453	Colon(174;1412 1962 45296 46549 47110)		NA											37	34					0	0	0.004289	0	0
CACNA1E	777	broad.mit.edu	37	1	181724430	181724430	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:181724430T>C	uc001gow.2	+	28	4051	c.3886T>C	c.(3886-3888)TAC>CAC	p.Y1296H	CACNA1E_uc009wxs.2_Missense_Mutation_p.Y1184H|CACNA1E_uc001gox.1_Missense_Mutation_p.Y522H|CACNA1E_uc009wxt.2_Missense_Mutation_p.Y522H	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1296	III.|Helical; Name=S5 of repeat III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						ACTCATTGTGTACAAGCTCTT	0.478			NA											27	101					0	0	0.005443	0	0
LAMC1	3915	broad.mit.edu	37	1	183086479	183086479	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:183086479A>C	uc001gpy.3	+	9	1846	c.1589A>C	c.(1588-1590)CAG>CCG	p.Q530P		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	530	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGTGCGGAACAGAGAGATGGC	0.478			NA											22	25					0	0	0.004656	0	0
TPR	7175	broad.mit.edu	37	1	186295264	186295264	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:186295264T>A	uc001grv.2	-	41	6290	c.5993A>T	c.(5992-5994)AAT>ATT	p.N1998I		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1998					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ataaccatcattgccatcggc	0.169			NA	T	NTRK1	papillary thyroid								44	65					0	0	0.00361	0	0
CRB1	23418	broad.mit.edu	37	1	197404400	197404400	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:197404400G>T	uc001gtz.2	+	9	3542	c.3407G>T	c.(3406-3408)GGC>GTC	p.G1136V	CRB1_uc010poz.1_Missense_Mutation_p.G1112V|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.G1024V|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.G617V|CRB1_uc001gub.1_Missense_Mutation_p.G785V	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1136	Extracellular (Potential).|Laminin G-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GTGGTCACTGGCTGTTTGCAG	0.413			NA											23	70					1.10923e-09	1.69929e-09	0.00278	1	0
CR2	1380	broad.mit.edu	37	1	207640047	207640047	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:207640047G>T	uc001hfw.2	+	2	329	c.235G>T	c.(235-237)GCT>TCT	p.A79S	CR2_uc001hfv.2_Missense_Mutation_p.A79S|CR2_uc009xch.2_Missense_Mutation_p.A79S	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	79	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GGATAAACCTGCTCCTAAATG	0.408			NA											38	61					6.97489e-18	1.26206e-17	0.004878	1	0
USH2A	7399	broad.mit.edu	37	1	216138697	216138697	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:216138697T>A	uc001hku.1	-	37	7469	c.7082A>T	c.(7081-7083)CAC>CTC	p.H2361L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2361	Extracellular (Potential).|Fibronectin type-III 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGGACTGAGTGTGTTAAGAG	0.378			NA								HNSCC(13;0.011)			65	89					0	0	0.00361	0	0
USH2A	7399	broad.mit.edu	37	1	216243576	216243576	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:216243576C>G	uc001hku.1	-	30	6303	c.5916G>C	c.(5914-5916)GAG>GAC	p.E1972D		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1972	Extracellular (Potential).|Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCCAGGTCACCTCAATGCTGT	0.483			NA								HNSCC(13;0.011)			37	37					0	0	0.002522	0	0
ESRRG	2104	broad.mit.edu	37	1	216741352	216741352	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:216741352C>A	uc001hkw.1	-	4	844	c.678G>T	c.(676-678)CTG>CTT	p.L226L	ESRRG_uc001hky.1_Silent_p.L203L|ESRRG_uc009xdp.1_Silent_p.L203L|ESRRG_uc001hkz.1_Silent_p.L164L|ESRRG_uc010puc.1_Silent_p.L203L|ESRRG_uc001hla.1_Silent_p.L203L|ESRRG_uc001hlb.1_Silent_p.L203L|ESRRG_uc010pud.1_Silent_p.L34L|ESRRG_uc001hlc.1_Silent_p.L203L|ESRRG_uc001hld.1_Silent_p.L203L|ESRRG_uc001hkx.1_Silent_p.L231L|ESRRG_uc009xdo.1_Silent_p.L203L|ESRRG_uc001hle.1_Silent_p.L203L	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	226					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CTGGCTGAACCAGCTGAGGGT	0.527			NA											18	77					9.16793e-09	1.35262e-08	0.00499	1	0
WNT3A	89780	broad.mit.edu	37	1	228246785	228246785	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:228246785C>A	uc001hrq.1	+	4	756	c.678C>A	c.(676-678)GCC>GCA	p.A226A	WNT3A_uc001hrp.1_Silent_p.A226A	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	226					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				ACTTCCGCGCCATCGGTGACT	0.657			NA											19	36					1.78486e-19	3.3108e-19	0.007413	1	0
OBSCN	84033	broad.mit.edu	37	1	228553830	228553830	+	Silent	SNP	G	G	A	rs74144615	by1000genomes	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:228553830G>A	uc009xez.1	+	83	19163	c.19119G>A	c.(19117-19119)ACG>ACA	p.T6373T	OBSCN_uc001hsr.1_Silent_p.T1002T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6373	Ig-like 54.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CAGGCGGAACGGCCCAATTCG	0.637			NA											25	43					0	0	0.003954	0	0
ACTA1	58	broad.mit.edu	37	1	229568170	229568170	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:229568170G>T	uc001htm.2	-	4	568	c.463C>A	c.(463-465)CTG>ATG	p.L155M		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	155					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	CCGGAGTCCAGCACGATGCCT	0.602			NA											22	20					1.77063e-15	3.07059e-15	0.005443	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232650001	232650001	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:232650001G>A	uc001hvg.2	-	1	1243	c.1085C>T	c.(1084-1086)TCT>TTT	p.S362F		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	362					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GGATGCTGCAGATGCCCCAGT	0.498			NA											56	73					0	0	0.00361	0	0
ACTN2	88	broad.mit.edu	37	1	236925788	236925788	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:236925788C>T	uc001hyf.2	+	21	2758	c.2554C>T	c.(2554-2556)CGG>TGG	p.R852W	ACTN2_uc001hyg.2_Missense_Mutation_p.R644W|ACTN2_uc009xgi.1_Missense_Mutation_p.R852W|ACTN2_uc010pxu.1_Missense_Mutation_p.R541W|ACTN2_uc001hyh.2_Missense_Mutation_p.R540W	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	852					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GGAGCTGCGTCGGGAGCTGCC	0.547			NA											25	39					0	0	0.004656	0	0
RYR2	6262	broad.mit.edu	37	1	237754103	237754103	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:237754103G>T	uc001hyl.1	+	31	4091	c.3971G>T	c.(3970-3972)GGG>GTG	p.G1324V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1324	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGGCTCCCTGGGGCTGGCCTT	0.522			NA											34	84					1.61788e-16	2.84166e-16	0.002445	1	0
RYR2	6262	broad.mit.edu	37	1	237880573	237880573	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:237880573G>T	uc001hyl.1	+	72	10519	c.10399G>T	c.(10399-10401)GTA>TTA	p.V3467L	RYR2_uc010pxz.1_Missense_Mutation_p.V422L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3467					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTCTCTGATTGTAGCAGCTCT	0.498			NA											16	18					2.31682e-05	3.09447e-05	0.003163	1	0
AKT3	10000	broad.mit.edu	37	1	243858929	243858929	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:243858929C>G	uc001iab.1	-	2	217	c.136G>C	c.(136-138)GAT>CAT	p.D46H	AKT3_uc001hzz.1_Missense_Mutation_p.D46H	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	46	PH.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			TAAGGTAAATCCACATCTTGA	0.318			NA											7	18					0	0	0.00308	0	0
PPPDE1	51029	broad.mit.edu	37	1	244849926	244849926	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:244849926A>T	uc001iao.2	+	2	334	c.70A>T	c.(70-72)ATT>TTT	p.I24F	PPPDE1_uc001iap.2_Missense_Mutation_p.I24F	NM_016076	NP_057160	Q9BSY9	PPDE1_HUMAN	PPPDE peptidase domain containing 1	24	PPPDE peptidase.									breast(3)	3						TACCTCATCCATTGGAATTGG	0.363			NA											13	30					0	0	0.001855	0	0
VN1R5	317705	broad.mit.edu	37	1	247419548	247419548	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:247419548G>T	uc010pyu.1	+	2	175	c.175G>T	c.(175-177)GCA>TCA	p.A59S		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	59	Helical; Name=2; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			TGGAATTTCAGCAAACACCAT	0.358	GBM(98;63 1399 4825 21305 33017)		NA											38	102					6.97489e-18	1.26206e-17	0.004878	1	0
OR1C1	26188	broad.mit.edu	37	1	247920989	247920989	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:247920989G>T	uc010pza.1	-	1	720	c.720C>A	c.(718-720)ACC>ACA	p.T240T		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGCAGCTGCAGGTGGAAACAG	0.527			NA											28	9					4.22769e-11	6.63561e-11	0.00632	1	0
OR2W3	343171	broad.mit.edu	37	1	248059669	248059669	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:248059669C>A	uc001idp.1	+	3	1050	c.781C>A	c.(781-783)CAG>AAG	p.Q261K	OR2W3_uc010pzb.1_Missense_Mutation_p.Q261K	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CATGTACATGCAGCCAGGAGC	0.522			NA											27	70					4.7796e-09	7.15076e-09	0.004656	1	0
OR2L8	391190	broad.mit.edu	37	1	248112502	248112502	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:248112502G>C	uc001idt.1	+	1	343	c.343G>C	c.(343-345)GCA>CCA	p.A115P	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACTACTTTTGGCATCTATGGC	0.438			NA											113	95					0	0	0.00361	0	0
OR2L13	284521	broad.mit.edu	37	1	248262910	248262910	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:248262910C>T	uc001ids.2	+	3	570	c.233C>T	c.(232-234)CCC>CTC	p.P78L		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	78	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ACCACCGTCCCCAAGATGGCG	0.537			NA											50	72					0	0	0.00361	0	0
OR2M4	26245	broad.mit.edu	37	1	248402768	248402768	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:248402768G>T	uc010pzh.1	+	1	538	c.538G>T	c.(538-540)GAT>TAT	p.D180Y		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTTTTTCTGTGATGTTGCTGC	0.428			NA											36	56					6.70999e-13	1.08514e-12	0.004289	1	0
OR2T12	127064	broad.mit.edu	37	1	248458340	248458340	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:248458340C>T	uc010pzj.1	-	1	541	c.541G>A	c.(541-543)GTG>ATG	p.V181M		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CGCACCAACACGGGGGCCTCG	0.562			NA											21	43					0	0	0.001882	0	0
OR14C36	127066	broad.mit.edu	37	1	248512579	248512579	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr1:248512579G>T	uc010pzl.1	+	1	503	c.503G>T	c.(502-504)CGG>CTG	p.R168L		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CCCTTCTGTCGGTCCAACGTT	0.502			NA											22	31					2.21704e-12	3.54948e-12	0.00278	1	0
ITIH2	3698	broad.mit.edu	37	10	7773912	7773912	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:7773912G>T	uc001ijs.2	+	13	1762	c.1600G>T	c.(1600-1602)GAC>TAC	p.D534Y		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	534					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						AGGAAAATTTGACCCTGCTAA	0.423			NA											16	47					6.49762e-13	1.05257e-12	0.006122	1	0
CUBN	8029	broad.mit.edu	37	10	16930475	16930475	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:16930475A>T	uc001ioo.2	-	56	8898	c.8846T>A	c.(8845-8847)GTC>GAC	p.V2949D	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.V305D	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2949	CUB 22.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCCTCTATGACATAGGTGCA	0.353			NA											12	43					0	0	0.000978	0	0
CUBN	8029	broad.mit.edu	37	10	17087992	17087992	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:17087992T>C	uc001ioo.2	-	24	3483	c.3431A>G	c.(3430-3432)AAG>AGG	p.K1144R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1144	CUB 6.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGGTCACTCTTAAATTTTAA	0.398			NA											23	50					0	0	0.004656	0	0
SLC39A12	221074	broad.mit.edu	37	10	18270281	18270281	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:18270281A>G	uc001ipo.2	+	6	1238	c.965A>G	c.(964-966)CAG>CGG	p.Q322R	SLC39A12_uc001ipn.2_Missense_Mutation_p.Q322R|SLC39A12_uc001ipp.2_Missense_Mutation_p.Q322R|SLC39A12_uc010qck.1_Missense_Mutation_p.Q188R	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	322	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						ATATTTCTACAGAAGGGCCTC	0.458			NA											16	40					0	0	0.00499	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702943	27702943	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:27702943C>A	uc001itu.2	-	1	355	c.237G>T	c.(235-237)TCG>TCT	p.S79S		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	79					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CGTCCAGCATCGACGGCCGGG	0.716			NA											9	42					2.17888e-05	2.91836e-05	0.006214	1	0
ZNF37A	7587	broad.mit.edu	37	10	38403763	38403763	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:38403763G>A	uc001izk.2	+	6	915	c.96G>A	c.(94-96)CTG>CTA	p.L32L	ZNF37A_uc001izl.2_Silent_p.L32L|ZNF37A_uc001izm.2_Silent_p.L32L	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	32	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						AGAGGACCCTGTACAGGGATG	0.493			NA											20	96					0	0	0.001523	0	0
CHAT	1103	broad.mit.edu	37	10	50835818	50835818	+	Silent	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:50835818G>C	uc001jhz.2	+	7	1251	c.1098G>C	c.(1096-1098)ACG>ACC	p.T366T	CHAT_uc001jhv.1_Silent_p.T248T|CHAT_uc001jhx.1_Silent_p.T248T|CHAT_uc001jhy.1_Silent_p.T248T|CHAT_uc001jia.2_Silent_p.T248T|CHAT_uc010qgs.1_Silent_p.T248T	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	366					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	AGGCCAGGACGGTCCTCGTGA	0.602			NA											15	30					0	0	0.003163	0	0
ANK3	288	broad.mit.edu	37	10	61844412	61844412	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:61844412G>A	uc001jky.2	-	32	4214	c.4022C>T	c.(4021-4023)ACT>ATT	p.T1341I	ANK3_uc001jkw.2_Missense_Mutation_p.T475I|ANK3_uc009xpa.2_Missense_Mutation_p.T475I|ANK3_uc001jkx.2_Missense_Mutation_p.T519I|ANK3_uc010qih.1_Missense_Mutation_p.T1342I|ANK3_uc001jkz.3_Missense_Mutation_p.T1335I|ANK3_uc001jla.1_Missense_Mutation_p.T407I|ANK3_uc001jlb.1_Missense_Mutation_p.T859I|ANK3_uc001jkv.2_5'Flank	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1341					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTGCTCTAAAGTTTTGTCCAC	0.373			NA											20	163					0	0	0.003954	0	0
GRID1	2894	broad.mit.edu	37	10	87373338	87373338	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:87373338G>T	uc001kdl.1	-	15	2528	c.2427C>A	c.(2425-2427)GGC>GGA	p.G809G	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.G380G	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	809	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GGTCACAGCGGCCCATGTGCG	0.612			NA								Multiple Myeloma(13;0.14)			16	50					5.01169e-05	6.63842e-05	0.00499	1	0
GRID1	2894	broad.mit.edu	37	10	87628928	87628928	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:87628928C>A	uc001kdl.1	-	6	891	c.790G>T	c.(790-792)GAC>TAC	p.D264Y	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	264	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ATCTCCGGGTCACTGATTTCC	0.502			NA								Multiple Myeloma(13;0.14)			30	53					1.99505e-19	3.68643e-19	0.002445	1	0
PIPSL	266971	broad.mit.edu	37	10	95719309	95719309	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:95719309G>C	uc009xuj.2	-	1	2364	c.1845C>G	c.(1843-1845)TGC>TGG	p.C615W		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						CCTTCTTGAGGCATTTAGCCA	0.443			NA											7	28					0	0	0.004482	0	0
PLCE1	51196	broad.mit.edu	37	10	96005999	96005999	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:96005999C>A	uc001kjk.2	+	8	3351	c.2717C>A	c.(2716-2718)GCA>GAA	p.A906E	PLCE1_uc010qnx.1_Missense_Mutation_p.A906E|PLCE1_uc001kjm.2_Missense_Mutation_p.A598E	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	906					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				AGCAGTAAAGCAAAACTTGGT	0.512			NA											18	35					0.000566183	0.000727841	0.00499	1	0
SORBS1	10580	broad.mit.edu	37	10	97078119	97078119	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:97078119T>C	uc001kkp.2	-	30	3814	c.3769A>G	c.(3769-3771)ATC>GTC	p.I1257V	SORBS1_uc001kkk.2_Missense_Mutation_p.I513V|SORBS1_uc001kkl.2_Missense_Mutation_p.I601V|SORBS1_uc001kkn.2_Missense_Mutation_p.I764V|SORBS1_uc001kkm.2_Missense_Mutation_p.I799V|SORBS1_uc001kko.2_Missense_Mutation_p.I1116V|SORBS1_uc001kkq.2_Missense_Mutation_p.I870V|SORBS1_uc001kkr.2_Missense_Mutation_p.I705V|SORBS1_uc001kks.2_Missense_Mutation_p.I649V|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Missense_Mutation_p.I746V|SORBS1_uc001kkv.2_Missense_Mutation_p.I781V|SORBS1_uc001kkw.2_Missense_Mutation_p.I1231V|SORBS1_uc010qoe.1_Missense_Mutation_p.I714V	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1257	SH3 3.				focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		ACATCAACGATATCTCCATCG	0.368			NA											22	72					0	0	0.003954	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98376423	98376423	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:98376423C>A	uc001kmq.2	-	13	2115	c.1987G>T	c.(1987-1989)GAG>TAG	p.E663*	PIK3AP1_uc001kmo.2_Nonsense_Mutation_p.E262*|PIK3AP1_uc001kmp.2_Nonsense_Mutation_p.E485*	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	663	Potential.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		TTTTGCTTCTCTCTCTGTCTT	0.433			NA											32	45					8.73648e-17	1.54867e-16	0.004289	1	0
C10orf28	27291	broad.mit.edu	37	10	99968119	99968119	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:99968119G>T	uc001kow.3	+	4	543	c.248G>T	c.(247-249)AGA>ATA	p.R83I	C10orf28_uc001kox.3_Missense_Mutation_p.R83I|C10orf28_uc001koy.3_Missense_Mutation_p.R83I|C10orf28_uc009xvx.2_Missense_Mutation_p.R83I|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	83							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		CATAATTGTAGAGAAGAAAAG	0.343			NA											27	92					6.32553e-13	1.02643e-12	0.004656	1	0
FBXW4	6468	broad.mit.edu	37	10	103427688	103427688	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:103427688T>C	uc001kto.2	-	5	1071	c.725A>G	c.(724-726)CAG>CGG	p.Q242R		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	242					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		GTCTTCAGTCTGGATGGTGTG	0.498			NA											50	38					0	0	0.00361	0	0
PSD	5662	broad.mit.edu	37	10	104176638	104176638	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:104176638G>A	uc001kvg.1	-	2	685	c.158C>T	c.(157-159)CCA>CTA	p.P53L	PSD_uc001kvh.1_Intron|PSD_uc009xxd.1_Missense_Mutation_p.P53L|PSD_uc001kvi.1_Missense_Mutation_p.P53L|FBXL15_uc001kvj.1_5'Flank|FBXL15_uc001kvk.2_5'Flank	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	53	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TCGAGGACCTGGACCTGCCAC	0.697			NA											6	18					0	0	0.00308	0	0
NRAP	4892	broad.mit.edu	37	10	115384620	115384620	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:115384620G>A	uc001laj.2	-	22	2478	c.2314C>T	c.(2314-2316)CTG>TTG	p.L772L	NRAP_uc009xyb.2_Silent_p.L83L|NRAP_uc001lak.2_Silent_p.L737L|NRAP_uc001lal.3_Silent_p.L772L	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	772	Nebulin 19.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CGGGCCTGCAGGAAGAGAGGC	0.532			NA											11	97					0	0	0.00499	0	0
CUZD1	50624	broad.mit.edu	37	10	124593398	124593398	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:124593398G>A	uc001lgq.2	-	8	1773	c.1441C>T	c.(1441-1443)CAG>TAG	p.Q481*	CUZD1_uc001lgp.2_Nonsense_Mutation_p.Q200*|CUZD1_uc009yad.2_Nonsense_Mutation_p.Q200*|CUZD1_uc009yaf.2_Nonsense_Mutation_p.Q115*|CUZD1_uc001lgr.2_Nonsense_Mutation_p.Q200*|CUZD1_uc010qty.1_Nonsense_Mutation_p.Q200*|CUZD1_uc009yae.2_Nonsense_Mutation_p.Q200*|CUZD1_uc001lgs.2_Nonsense_Mutation_p.Q481*|CUZD1_uc010qtz.1_Nonsense_Mutation_p.Q481*	NM_022034	NP_071317	Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1 precursor	481	Extracellular (Potential).|ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				ovary(1)|skin(1)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GCATTAAACTGGAATCTCCCA	0.378			NA											13	53					0	0	0.001855	0	0
PSTK	118672	broad.mit.edu	37	10	124740202	124740202	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:124740202G>A	uc001lgy.1	+	1	647	c.207G>A	c.(205-207)GCG>GCA	p.A69A		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	69							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		GGGCAAGAGCGCGACCGGCGG	0.592			NA									OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	9					0	0	0.001168	0	0
C10orf90	118611	broad.mit.edu	37	10	128192828	128192828	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:128192828G>A	uc001ljq.2	-	3	1062	c.941C>T	c.(940-942)CCA>CTA	p.P314L	C10orf90_uc001ljp.2_Missense_Mutation_p.P267L|C10orf90_uc010qum.1_Missense_Mutation_p.P411L|C10orf90_uc009yao.2_Missense_Mutation_p.P411L|C10orf90_uc001ljs.1_Missense_Mutation_p.P267L	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	314										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TTCGCTTATTGGCTCTCTGTT	0.532			NA									OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	32					0	0	0.00623	0	0
C10orf90	118611	broad.mit.edu	37	10	128193239	128193239	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:128193239G>A	uc001ljq.2	-	3	651	c.530C>T	c.(529-531)CCC>CTC	p.P177L	C10orf90_uc001ljp.2_Missense_Mutation_p.P130L|C10orf90_uc010qum.1_Missense_Mutation_p.P274L|C10orf90_uc009yao.2_Missense_Mutation_p.P274L|C10orf90_uc001ljs.1_Missense_Mutation_p.P130L	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	177										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		CAGAGCCGGGGGCGCCTGGAA	0.667			NA									OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	64					0	0	0.003954	0	0
MUC2	4583	broad.mit.edu	37	11	1093613	1093613	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:1093613C>T	uc001lsx.1	+	31	12545	c.12518C>T	c.(12517-12519)CCA>CTA	p.P4173L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4173						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACACAGACCCCAACCATGATA	0.438			NA											26	18					0	0	0.003954	0	0
IGF2	3481	broad.mit.edu	37	11	2156610	2156610	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:2156610G>T	uc009yde.2	-	2	247	c.144C>A	c.(142-144)CGC>CGA	p.R48R	IGF2_uc001lvf.2_5'Flank|IGF2_uc001lvg.2_Silent_p.R48R|IGF2_uc009ydf.2_Silent_p.R104R|IGF2_uc001lvh.2_Silent_p.R48R|INS-IGF2_uc001lvi.2_RNA|MIR483_hsa-mir-483|MI0002467_5'Flank|INS-IGF2_uc001lvj.1_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	48	B.				glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		AGTAGAAGCCGCGGTCCCCAC	0.637			NA											9	6					1.58986e-06	2.2161e-06	0.008291	1	0
ZNF195	7748	broad.mit.edu	37	11	3392868	3392868	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:3392868G>A	uc001lxt.2	-	2	247	c.69C>T	c.(67-69)CTC>CTT	p.L23L	ZNF195_uc001lxv.2_Silent_p.L23L|ZNF195_uc001lxs.2_Silent_p.L23L|ZNF195_uc010qxr.1_Silent_p.L27L|ZNF195_uc009ydz.2_Silent_p.L27L|ZNF195_uc001lxu.2_Silent_p.L27L	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	23	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		TCTGCTGAGCGAGGTCCAGGC	0.443			NA											28	57					0	0	0.008361	0	0
OR52I1	390037	broad.mit.edu	37	11	4616129	4616129	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:4616129C>A	uc010qyi.1	+	1	861	c.861C>A	c.(859-861)ATC>ATA	p.I287I		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTACGTGATCATCCCAGCCA	0.498			NA											54	49					9.57592e-29	1.9415e-28	0.00361	1	0
OR52R1	119695	broad.mit.edu	37	11	4825134	4825134	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:4825134C>A	uc010qym.1	-	1	714	c.714G>T	c.(712-714)GTG>GTT	p.V238V		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGAAGGGGCTCACCCACAGCA	0.562			NA											49	37					3.21987e-24	6.25072e-24	0.00361	1	0
OR56A4	120793	broad.mit.edu	37	11	6024341	6024341	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:6024341A>T	uc010qzv.1	-	1	38	c.38T>A	c.(37-39)ATA>AAA	p.I13K		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	Error:Variant_position_missing_in_Q8NGH8_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGCCCTGTATCTGTCCCAA	0.294			NA											27	36					0	0	0.002096	0	0
FAM160A2	84067	broad.mit.edu	37	11	6240220	6240220	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:6240220G>A	uc001mcl.3	-	7	1611	c.1252C>T	c.(1252-1254)CTG>TTG	p.L418L	FAM160A2_uc001mck.3_Silent_p.L418L|FAM160A2_uc001mcm.2_Silent_p.L418L	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	418					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						AGCTGCAGCAGGACATCCTCA	0.577			NA											18	13					0	0	0.006122	0	0
OR6A2	8590	broad.mit.edu	37	11	6816722	6816722	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:6816722C>A	uc001mes.1	-	1	418	c.218G>T	c.(217-219)TGG>TTG	p.W73L		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGTGACATACCAGATCTCCAG	0.438			NA											19	60					2.54575e-18	4.67696e-18	0.001523	1	0
SYT9	143425	broad.mit.edu	37	11	7441858	7441858	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:7441858C>A	uc001mfe.2	+	6	1696	c.1459C>A	c.(1459-1461)CTG>ATG	p.L487M	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	487	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CTGGCATTCCCTGGTGGAGGT	0.507			NA											33	28					7.63505e-26	1.51281e-25	0.002445	1	0
NLRP10	338322	broad.mit.edu	37	11	7984990	7984990	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:7984990C>A	uc001mfv.1	-	1	70	c.53G>T	c.(52-54)AGT>ATT	p.S18I		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	18	DAPIN.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCAAGGTCACTCAAGGCCCA	0.572			NA											18	47					5.3912e-06	7.36491e-06	0.006122	1	0
GALNTL4	374378	broad.mit.edu	37	11	11292739	11292739	+	Silent	SNP	C	C	G	rs140917604		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:11292739C>G	uc001mjo.2	-	11	2197	c.1776G>C	c.(1774-1776)TCG>TCC	p.S592S		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	592	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		AGTGCTGGCCCGAGCACTTCT	0.617			NA											37	26					0	0	0.005524	0	0
KCNC1	3746	broad.mit.edu	37	11	17758089	17758089	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:17758089C>T	uc001mnk.3	+	1	595	c.540C>T	c.(538-540)TTC>TTT	p.F180F	KCNC1_uc009yhc.1_Silent_p.F180F	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	180	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						GGGCGCTCTTCGAGGACCCGT	0.687			NA											8	6					0	0	0.00308	0	0
UEVLD	55293	broad.mit.edu	37	11	18587914	18587914	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:18587914T>C	uc001mot.2	-	5	553	c.473A>G	c.(472-474)TAT>TGT	p.Y158C	UEVLD_uc001mou.2_Missense_Mutation_p.Y158C|UEVLD_uc010rde.1_Missense_Mutation_p.Y28C|UEVLD_uc010rdf.1_Missense_Mutation_p.Y136C|UEVLD_uc010rdg.1_Missense_Mutation_p.Y28C|UEVLD_uc001mov.2_Missense_Mutation_p.Y136C|UEVLD_uc010rdh.1_Missense_Mutation_p.Y158C	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	158					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						TTTTGCAATATAGGCTAGCAA	0.378			NA											45	22					0	0	0.002522	0	0
PTPN5	84867	broad.mit.edu	37	11	18765577	18765577	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:18765577G>T	uc001mpd.2	-	4	698	c.267C>A	c.(265-267)TGC>TGA	p.C89*	PTPN5_uc001mpb.2_Nonsense_Mutation_p.C89*|PTPN5_uc001mpc.2_Nonsense_Mutation_p.C89*|PTPN5_uc001mpe.2_Nonsense_Mutation_p.C89*|PTPN5_uc010rdj.1_Nonsense_Mutation_p.C65*|PTPN5_uc001mpf.2_Nonsense_Mutation_p.C65*|PTPN5_uc010rdk.1_Nonsense_Mutation_p.C34*	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	89						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						CAGCGAACAGGCACAGGCTGC	0.662			NA											27	57					3.65163e-15	6.25341e-15	0.00632	1	0
SLC6A5	9152	broad.mit.edu	37	11	20622673	20622673	+	Splice_Site	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:20622673A>T	uc001mqd.2	+	2	277	c.4_splice	c.e2-2	p.D2_splice	SLC6A5_uc009yic.2_Splice_Site	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter						synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TTGTGTTTGCAGGATTGCAGT	0.532			NA											4	9					0	0	0.000602	0	0
SLC17A6	57084	broad.mit.edu	37	11	22363101	22363101	+	Silent	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:22363101G>C	uc001mqk.2	+	2	527	c.114G>C	c.(112-114)GGG>GGC	p.G38G		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	38	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						AAGACACCGGGGAGACAATCG	0.642			NA											13	63					0	0	0.004007	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725171	26725171	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:26725171A>T	uc001mra.2	-	6	1041	c.728T>A	c.(727-729)GTG>GAG	p.V243E	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Missense_Mutation_p.V243E	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	243	Helical; (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						AGTTCCTCCCACTGTGATAGT	0.408			NA											33	131					0	0	0.002096	0	0
Unknown	0	broad.mit.edu	37	11	31125268	31125268	+	Silent	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:31125268T>C	uc009yjk.1	-	2	213	c.144A>G	c.(142-144)GCA>GCG	p.A48A	uc009yjl.1_5'UTR|DCDC1_uc001msu.1_Silent_p.A219A					RecName: Full=Doublecortin domain-containing protein 5;												NA						CTCTGGCAAATGCACTCACTC	0.368			NA											57	25					0	0	0.00361	0	0
C11orf41	25758	broad.mit.edu	37	11	33565256	33565256	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:33565256T>G	uc001mup.3	+	1	1380	c.1256T>G	c.(1255-1257)TTG>TGG	p.L419W	C11orf41_uc001mun.1_Missense_Mutation_p.L419W	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	419						integral to membrane				ovary(2)	2						ATATCTGGCTTGCAGCAGCAA	0.398			NA									OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	47					0	0	0.006214	0	0
PAMR1	25891	broad.mit.edu	37	11	35456226	35456226	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:35456226A>G	uc001mwg.2	-	10	1503	c.1460T>C	c.(1459-1461)CTA>CCA	p.L487P	PAMR1_uc001mwf.2_Missense_Mutation_p.L504P|PAMR1_uc010rew.1_Missense_Mutation_p.L376P|PAMR1_uc010rex.1_Missense_Mutation_p.L447P	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	487	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GCTGCAGACTAGGAACCACGC	0.617			NA											53	37					0	0	0.00361	0	0
PRR5L	79899	broad.mit.edu	37	11	36484178	36484178	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:36484178C>G	uc001mwo.3	+	9	1388	c.999C>G	c.(997-999)CAC>CAG	p.H333Q	PRR5L_uc001mwp.2_Missense_Mutation_p.H333Q|PRR5L_uc009ykk.2_Missense_Mutation_p.H205Q|PRR5L_uc010rfc.1_3'UTR	NM_001160167	NP_001153639	Q6MZQ0	PRR5L_HUMAN	protor-2 isoform a	333										ovary(1)	1						CCCCGCCCCACCGGCAGTGCT	0.672			NA											26	15					0	0	0.003954	0	0
ALX4	60529	broad.mit.edu	37	11	44289130	44289130	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:44289130G>T	uc001myb.2	-	3	924	c.820C>A	c.(820-822)CGT>AGT	p.R274S		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	274					hair follicle development						0						TGCCCAAAACGCTCCCGCTTC	0.597			NA											49	31					6.4308e-24	1.23838e-23	0.00361	1	0
LRP4	4038	broad.mit.edu	37	11	46898090	46898090	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:46898090C>A	uc001ndn.3	-	25	3609	c.3463G>T	c.(3463-3465)GGG>TGG	p.G1155W		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1155	Extracellular (Potential).|LDL-receptor class B 12.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CGCATGGACCCGTCCAGGTTG	0.572			NA											62	47					5.82218e-30	1.19305e-29	0.00361	1	0
OR4A16	81327	broad.mit.edu	37	11	55111468	55111468	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55111468C>T	uc010rie.1	+	1	792	c.792C>T	c.(790-792)CCC>CCT	p.P264P		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						CCAACTTTCCCTTTGATAAAT	0.368			NA											10	28					0	0	0.008291	0	0
OR4C15	81309	broad.mit.edu	37	11	55321937	55321937	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55321937T>A	uc010rig.1	+	1	155	c.155T>A	c.(154-156)TTG>TAG	p.L52*		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCTTTTCCTTGGGAAACATG	0.353			NA								HNSCC(20;0.049)			80	68					0	0	0.00361	0	0
OR4C15	81309	broad.mit.edu	37	11	55322871	55322871	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55322871T>A	uc010rig.1	+	1	1089	c.1089T>A	c.(1087-1089)GAT>GAA	p.D363E		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGTTTCTGATGAGAAAGAAA	0.318			NA								HNSCC(20;0.049)			11	28					0	0	0.000978	0	0
OR4C15	81309	broad.mit.edu	37	11	55322888	55322888	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55322888A>C	uc010rig.1	+	1	1106	c.1106A>C	c.(1105-1107)AAA>ACA	p.K369T		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	315	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAAAATATTAAACTTTAAAAA	0.308			NA								HNSCC(20;0.049)			7	18					0	0	0.00308	0	0
OR4C11	219429	broad.mit.edu	37	11	55371095	55371095	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55371095C>A	uc010rii.1	-	1	755	c.755G>T	c.(754-756)TGT>TTT	p.C252F		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TATGAATATACATGGGCCAAA	0.438			NA											42	5					2.77807e-22	5.3177e-22	0.003214	1	0
OR5D16	390144	broad.mit.edu	37	11	55607040	55607040	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55607040C>T	uc010rio.1	+	1	813	c.813C>T	c.(811-813)CAC>CAT	p.H271H		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				ACTCCAGGCACACAGTCAAAG	0.488			NA											17	45					0	0	0.004007	0	0
OR5F1	338674	broad.mit.edu	37	11	55761952	55761953	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55761952_55761953CC>AT	uc010riv.1	-	1	149_150	c.149_150GG>AT	c.(148-150)AGG>AAT	p.R50N		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GGGAATCGATCCTGATTAAGAG	0.436			NA											12	48					0	0	0.004672	0	0
OR8K5	219453	broad.mit.edu	37	11	55926917	55926917	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:55926917T>C	uc010rja.1	-	1	877	c.877A>G	c.(877-879)AGA>GGA	p.R293G		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				TCTTCGTTTCTTAAGCTGTAA	0.299			NA											18	59					0	0	0.006122	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431458	56431459	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:56431458_56431459CC>AA	uc010rjm.1	+	1	297_298	c.297_298CC>AA	c.(295-300)ACCCAG>ACAAAG	p.Q100K		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTGTGCCACCCAGTTTGCTTT	0.505			NA											79	101					0	0	0.004672	0	0
OR4D11	219986	broad.mit.edu	37	11	59271420	59271420	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:59271420G>T	uc001noa.1	+	1	372	c.372G>T	c.(370-372)ATG>ATT	p.M124I		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACTGCTACATGGCCATCTCCA	0.512			NA											36	108					3.61848e-18	6.5971e-18	0.007835	1	0
MS4A1	931	broad.mit.edu	37	11	60230578	60230578	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:60230578T>A	uc001npp.2	+	4	679	c.263T>A	c.(262-264)CTC>CAC	p.L88H	MS4A1_uc009ymy.1_Missense_Mutation_p.L88H|MS4A1_uc001npq.2_Missense_Mutation_p.L88H|MS4A1_uc009yna.2_Missense_Mutation_p.L88H|MS4A1_uc009ymz.2_Missense_Mutation_p.L88H|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	88	Helical; (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	TGGTACCCTCTCTGGGGAGGC	0.478			NA											27	82					0	0	0.001786	0	0
FADS3	3995	broad.mit.edu	37	11	61646289	61646289	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:61646289C>A	uc001nsm.2	-	4	706	c.553G>T	c.(553-555)GGC>TGC	p.G185C	FADS3_uc001nsn.2_Missense_Mutation_p.G61C	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	185	Cytoplasmic (Potential).|Histidine box-1.				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						GAGGCATGGCCCAGGTCATGC	0.632			NA											21	28					0.000295444	0.000383397	0.002299	1	0
AHNAK	79026	broad.mit.edu	37	11	62292378	62292378	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:62292378C>G	uc001ntl.2	-	5	9811	c.9511G>C	c.(9511-9513)GAC>CAC	p.D3171H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3171					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGGTTCACGTCCACTTCTGGA	0.502			NA											196	167					0	0	0.00361	0	0
SLC22A8	9376	broad.mit.edu	37	11	62766562	62766562	+	Splice_Site	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:62766562C>T	uc001nwo.2	-	5	729	c.593_splice	c.e5-1	p.N198_splice	SLC22A8_uc001nwn.1_5'UTR|SLC22A8_uc001nwp.2_Splice_Site_p.N198_splice|SLC22A8_uc009yom.2_Splice_Site_p.N75_splice|SLC22A8_uc010rmm.1_Splice_Site_p.N107_splice|SLC22A8_uc009yon.2_Splice_Site_p.N198_splice	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8						response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						CATTCCACATCTGTGGGAGGA	0.607			NA											13	34					0	0	0.001855	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141448	63141448	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:63141448G>A	uc001nww.2	+	4	1012	c.744G>A	c.(742-744)CTG>CTA	p.L248L	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	248	Helical; (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						TTATGACCCTGGCAGGCCTGG	0.473			NA											12	40					0	0	0.001368	0	0
SLC22A12	116085	broad.mit.edu	37	11	64359072	64359072	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:64359072G>T	uc001oam.1	+	1	791	c.44G>T	c.(43-45)AGG>ATG	p.R15M	SLC22A12_uc009ypr.1_Missense_Mutation_p.R15M|SLC22A12_uc001oal.1_Intron|SLC22A12_uc009yps.1_Missense_Mutation_p.R15M|SLC22A12_uc001oan.1_Missense_Mutation_p.R15M|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	15	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GGCCTGGGCAGGTTCCAGGTT	0.617			NA											8	117					7.48243e-07	1.05369e-06	0.006214	1	0
DPF2	5977	broad.mit.edu	37	11	65111510	65111510	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:65111510G>T	uc001odm.2	+	6	619	c.607G>T	c.(607-609)GAG>TAG	p.E203*	DPF2_uc001odn.2_Nonsense_Mutation_p.E203*|DPF2_uc010roe.1_Intron	NM_006268	NP_006259	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	203					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						TTCCATCCTGGAGGACCGGGA	0.567			NA											27	35					2.44723e-14	4.10296e-14	0.004656	1	0
CD248	57124	broad.mit.edu	37	11	66083697	66083697	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:66083697C>A	uc001ohm.1	-	1	819	c.802G>T	c.(802-804)GGG>TGG	p.G268W		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	268	Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	CAACTGCGCCCGTCTGCTGCC	0.672			NA											20	17					1.87028e-06	2.59566e-06	0.001882	1	0
POLD4	57804	broad.mit.edu	37	11	67120236	67120236	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:67120236C>G	uc001okm.2	-	3	372	c.225G>C	c.(223-225)CAG>CAC	p.Q75H	LOC100130987_uc010rpo.1_Intron|POLD4_uc001okn.2_RNA|POLD4_uc001oko.2_RNA|POLD4_uc001okp.1_3'UTR	NM_021173	NP_066996	Q9HCU8	DPOD4_HUMAN	DNA-directed DNA polymerase delta 4	75					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA-directed DNA polymerase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(15;3.08e-06)			CCAAGCCCATCTGCTTGGCCC	0.652			NA											16	32					0	0	0.007413	0	0
UVRAG	7405	broad.mit.edu	37	11	75562951	75562951	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:75562951C>T	uc001oxc.2	+	2	382	c.141C>T	c.(139-141)AAC>AAT	p.N47N	UVRAG_uc010rrw.1_5'UTR	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	47	C2.				DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						ATCTTCGGAACATTGCTGCCC	0.373			NA											35	120					0	0	0.00623	0	0
TSKU	25987	broad.mit.edu	37	11	76507537	76507537	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:76507537C>G	uc001oxt.2	+	2	1049	c.877C>G	c.(877-879)CCC>GCC	p.P293A		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	293	LRR 10.					extracellular region					0	Ovarian(111;0.112)					CAACCTGGTGCCCCTGCCTGA	0.682			NA											27	20					0	0	0.005443	0	0
C11orf82	220042	broad.mit.edu	37	11	82645081	82645081	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:82645081C>A	uc001ozt.2	+	6	2945	c.2701C>A	c.(2701-2703)CCA>ACA	p.P901T	C11orf82_uc010rsr.1_Missense_Mutation_p.P600T|C11orf82_uc010rss.1_Missense_Mutation_p.P600T|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	901					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						ACAAGAGTTACCAAGAAAGAA	0.348			NA											18	31					1.56452e-12	2.50899e-12	0.007413	1	0
CHORDC1	26973	broad.mit.edu	37	11	89935706	89935706	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:89935706T>A	uc001pdg.2	-	11	1276	c.866A>T	c.(865-867)AAG>ATG	p.K289M	CHORDC1_uc009yvz.2_Missense_Mutation_p.K270M	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing	289	Interaction with HSP90AA1 and HSP90AB1 (By similarity).|CS.				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				ATAACTTCGCTTTACATCAAT	0.383			NA											16	12					0	0	0.004007	0	0
FAT3	120114	broad.mit.edu	37	11	92533544	92533545	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:92533544_92533545CC>AA	uc001pdj.3	+	9	7382_7383	c.7365_7366CC>AA	c.(7363-7368)AACCAT>AAAAAT	p.2455_2456NH>KN		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2455_2456	Cadherin 22.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CATTGTCCAACCATCGGAAGCA	0.49			NA								TCGA Ovarian(4;0.039)			34	33					0	0	0.004672	0	0
FAT3	120114	broad.mit.edu	37	11	92577505	92577505	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:92577505C>G	uc001pdj.3	+	18	10989	c.10972C>G	c.(10972-10974)CCT>GCT	p.P3658A	FAT3_uc001pdi.3_Missense_Mutation_p.P98A	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3658	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAATGTGTCCCCTGAGGACTT	0.572			NA								TCGA Ovarian(4;0.039)			25	55					0	0	0.003954	0	0
FAT3	120114	broad.mit.edu	37	11	92577662	92577662	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:92577662G>T	uc001pdj.3	+	18	11146	c.11129G>T	c.(11128-11130)AGC>ATC	p.S3710I	FAT3_uc001pdi.3_Missense_Mutation_p.S150I	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3710	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGCACAGCAGCGAGTTCTAC	0.552			NA								TCGA Ovarian(4;0.039)			6	18					1.6384e-10	2.54244e-10	0.001984	1	0
FAT3	120114	broad.mit.edu	37	11	92615986	92615986	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:92615986T>A	uc001pdj.3	+	23	12381	c.12364T>A	c.(12364-12366)TGC>AGC	p.C4122S	FAT3_uc001pdi.3_Missense_Mutation_p.C562S	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4122	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTCCTTCCTCTGCAACTGCAC	0.627			NA								TCGA Ovarian(4;0.039)			5	11					0	0	0.000602	0	0
MTNR1B	4544	broad.mit.edu	37	11	92715175	92715175	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:92715175C>A	uc001pdk.1	+	2	889	c.786C>A	c.(784-786)ATC>ATA	p.I262I		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	262	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	TCTTTGCCATCTGCTGGGCTC	0.557			NA											28	101					7.01153e-11	1.09334e-10	0.007291	1	0
AMOTL1	154810	broad.mit.edu	37	11	94602564	94602564	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:94602564G>T	uc001pfb.2	+	12	2860	c.2690G>T	c.(2689-2691)GGC>GTC	p.G897V	AMOTL1_uc001pfc.2_Missense_Mutation_p.G847V	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	897						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CCCAGCCGCGGCCGGCTGAGC	0.642			NA											9	3					0.000442599	0.000570501	0.006214	1	0
ANGPTL5	253935	broad.mit.edu	37	11	101776570	101776570	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:101776570G>C	uc001pgl.2	-	4	846	c.250C>G	c.(250-252)CAA>GAA	p.Q84E		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	84					signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		ATAGAATTTTGCAAATTTCCT	0.279			NA											10	38					0	0	0.006214	0	0
CASP1	834	broad.mit.edu	37	11	104897037	104897037	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:104897037G>T	uc010rve.1	-	9	1180	c.1163C>A	c.(1162-1164)ACC>AAC	p.T388N	CASP1_uc001pig.2_Missense_Mutation_p.T295N|CASP1_uc001pik.2_Missense_Mutation_p.T351N|CASP1_uc010rvf.1_Missense_Mutation_p.T295N|CASP1_uc010rvg.1_Missense_Mutation_p.T367N|CASP1_uc010rvh.1_Missense_Mutation_p.T247N|CASP1_uc010rvi.1_Missense_Mutation_p.T72N|CASP1_uc001pim.3_Missense_Mutation_p.T388N|CASP1_uc009yxi.2_Missense_Mutation_p.T367N|CASP1_uc010rvj.1_Missense_Mutation_p.T388N	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	388					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TCTTTCAGTGGTGGGCATCTG	0.408	NSCLC(41;1246 1743 4934)		NA											11	69					9.31168e-06	1.26129e-05	0.001855	1	0
GRIA4	2893	broad.mit.edu	37	11	105789637	105789637	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:105789637T>A	uc001pix.2	+	11	1915	c.1469T>A	c.(1468-1470)GTT>GAT	p.V490D	GRIA4_uc001piw.2_Missense_Mutation_p.V490D	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	490	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GGAGAACTTGTTTATGGGGTA	0.353			NA											11	65					0	0	0.000978	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810228	106810228	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:106810228A>G	uc001pjg.1	-	4	1554	c.1164T>C	c.(1162-1164)ATT>ATC	p.I388I	GUCY1A2_uc010rvo.1_Silent_p.I388I|GUCY1A2_uc009yxn.1_Silent_p.I388I	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	388					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GCTTGGTTCTAATCACAAACG	0.443			NA											35	114					0	0	0.003755	0	0
EXPH5	23086	broad.mit.edu	37	11	108412428	108412428	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:108412428C>G	uc001pkk.2	-	2	342	c.231G>C	c.(229-231)ATG>ATC	p.M77I	EXPH5_uc010rwa.1_Missense_Mutation_p.M1I	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	77					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GTTGTTTTAACATTTGGCTAA	0.338			NA											20	53					0	0	0.008871	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110561301	110561301	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:110561301C>G	uc001pkz.1	-	3	442	c.157G>C	c.(157-159)GAT>CAT	p.D53H	ARHGAP20_uc001pky.1_Missense_Mutation_p.D30H|ARHGAP20_uc009yyb.1_Missense_Mutation_p.D17H|ARHGAP20_uc001pla.1_Missense_Mutation_p.D17H	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	53					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		AGGGCTTTATCCAGGATAAGA	0.398			NA											24	56					0	0	0.00278	0	0
C11orf53	341032	broad.mit.edu	37	11	111156507	111156507	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:111156507C>A	uc001plc.2	+	4	586	c.439C>A	c.(439-441)CAC>AAC	p.H147N		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	147											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CATCGCCCAGCACAGGGGCTC	0.652			NA											16	61					0.00316338	0.00398121	0.003163	1	0
ALG9	79796	broad.mit.edu	37	11	111709015	111709015	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:111709015C>A	uc001pmb.2	-	12	1359	c.1260G>T	c.(1258-1260)CTG>CTT	p.L420L	ALG9_uc001ply.2_Silent_p.L249L|ALG9_uc001plz.2_Silent_p.L256L|ALG9_uc010rwm.1_Silent_p.L427L|ALG9_uc010rwn.1_Silent_p.L374L|ALG9_uc010rwo.1_Silent_p.L248L|ALG9_uc009yyh.1_Silent_p.L315L	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	420	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		AGAGCCCAAACAGGAAGACAG	0.428			NA											22	19					1.28384e-07	1.84865e-07	0.001882	1	0
TTC12	54970	broad.mit.edu	37	11	113234595	113234595	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:113234595A>C	uc001pnu.2	+	20	1867	c.1762A>C	c.(1762-1764)ATC>CTC	p.I588L	TTC12_uc001pnv.2_Missense_Mutation_p.I594L|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Missense_Mutation_p.I438L	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	588							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		GATACTAGCTATCTGCACGAA	0.383			NA											14	34					0	0	0.004007	0	0
USP28	57646	broad.mit.edu	37	11	113673938	113673938	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:113673938C>A	uc001poh.2	-	23	2837	c.2804G>T	c.(2803-2805)GGG>GTG	p.G935V	USP28_uc001pog.2_Missense_Mutation_p.G611V|USP28_uc010rwy.1_Missense_Mutation_p.G778V|USP28_uc001poi.2_Missense_Mutation_p.G258V	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	935					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CCGGCGGGGCCCCTTCATCAG	0.458	Melanoma(4;162 555 7664)|GBM(79;500 2010 17506)|Esophageal Squamous(9;463 924 15765)		NA											17	60					2.35188e-11	3.72802e-11	0.006122	1	0
ZBTB16	7704	broad.mit.edu	37	11	113934619	113934619	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:113934619C>A	uc001pop.2	+	2	861	c.597C>A	c.(595-597)ACC>ACA	p.T199T	ZBTB16_uc001poo.1_Silent_p.T199T|ZBTB16_uc001poq.2_Silent_p.T199T	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	199					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		TGAGTCCCACCAAGGCTGCAG	0.597			NA											15	40					3.27435e-08	4.75773e-08	0.00245	1	0
FAM55D	54827	broad.mit.edu	37	11	114453455	114453455	+	Missense_Mutation	SNP	G	G	A	rs111330181		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:114453455G>A	uc001ppc.2	-	3	566	c.385C>T	c.(385-387)CGC>TGC	p.R129C	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	129						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		TGCTTCCTGCGTCCCAAGTGG	0.587			NA											15	35					0	0	0.004007	0	0
AMICA1	120425	broad.mit.edu	37	11	118081387	118081387	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:118081387G>A	uc001psk.2	-	4	413	c.239C>T	c.(238-240)CCT>CTT	p.P80L	AMICA1_uc001psh.2_Missense_Mutation_p.P41L|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.P70L|AMICA1_uc001psj.2_Missense_Mutation_p.P80L|AMICA1_uc010rxw.1_Missense_Mutation_p.P41L|AMICA1_uc010rxx.1_Missense_Mutation_p.P80L|AMICA1_uc001psl.1_Missense_Mutation_p.P36L	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	80	Ig-like V-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GCGCCCAATAGGCACACTGAG	0.507			NA											64	48					0	0	0.00361	0	0
TMEM136	219902	broad.mit.edu	37	11	120198194	120198194	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:120198194G>T	uc001pxh.1	+	2	107	c.44G>T	c.(43-45)GGC>GTC	p.G15V	TMEM136_uc001pxg.2_Missense_Mutation_p.G37V|TMEM136_uc010rzm.1_Missense_Mutation_p.G15V|TMEM136_uc001pxj.2_Missense_Mutation_p.G37V|TMEM136_uc009zas.1_5'UTR|TMEM136_uc001pxi.1_Intron	NM_174926	NP_777586	Q6ZRR5	TM136_HUMAN	transmembrane protein 136	15	Helical; (Potential).					integral to membrane				ovary(1)	1		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Hepatocellular(160;0.206)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.07e-06)		AGCCTGTGTGGCTGGCTCTCG	0.498			NA											23	36					3.62473e-10	5.59761e-10	0.001882	1	0
TECTA	7007	broad.mit.edu	37	11	120989334	120989334	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:120989334C>T	uc010rzo.1	+	6	1110	c.1110C>T	c.(1108-1110)CGC>CGT	p.R370R		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	370	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ATGAACACCGCAGAGGTTCAG	0.542			NA											32	82					0	0	0.002096	0	0
TECTA	7007	broad.mit.edu	37	11	121038900	121038900	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:121038900G>T	uc010rzo.1	+	18	5724	c.5724G>T	c.(5722-5724)TTG>TTT	p.L1908F		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1908	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGATCTCCTTGGATTCTGTTG	0.443			NA											44	111					4.75955e-12	7.5695e-12	0.00361	1	0
SORL1	6653	broad.mit.edu	37	11	121477927	121477927	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:121477927G>T	uc001pxx.2	+	37	5174	c.5094G>T	c.(5092-5094)TGG>TGT	p.W1698C	SORL1_uc010rzp.1_Missense_Mutation_p.W544C|SORL1_uc010rzq.1_Missense_Mutation_p.W313C	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1698	Extracellular (Potential).|Fibronectin type-III 2.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCAAGATGTGGGCCTCCCAGA	0.448			NA											16	12					4.35082e-09	6.52963e-09	0.001523	1	0
OR6T1	219874	broad.mit.edu	37	11	123813682	123813682	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:123813682G>A	uc010sab.1	-	1	864	c.864C>T	c.(862-864)TTC>TTT	p.F288F		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAGTGAAGATGAATGGGTTCA	0.517			NA											34	119					0	0	0.004878	0	0
OR6T1	219874	broad.mit.edu	37	11	123813927	123813927	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:123813927A>C	uc010sab.1	-	1	619	c.619T>G	c.(619-621)TTA>GTA	p.L207V		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAGCCCAGTAACACCAACGTA	0.532			NA											13	33					0	0	0.001368	0	0
BARX2	8538	broad.mit.edu	37	11	129306860	129306860	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr11:129306860C>A	uc001qfc.3	+	2	452	c.402C>A	c.(400-402)CGC>CGA	p.R134R		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	134	Homeobox.										0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		AGAAGCCCCGCCGGAGTCGCA	0.632			NA											15	10					0.000422831	0.000547227	0.004007	1	0
SLC6A13	6540	broad.mit.edu	37	12	369210	369210	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:369210G>C	uc001qic.1	-	2	62	c.9C>G	c.(7-9)AGC>AGG	p.S3R	SLC6A13_uc009zdj.1_Missense_Mutation_p.S3R|SLC6A13_uc010sdl.1_Missense_Mutation_p.S3R|SLC6A13_uc001qid.1_Missense_Mutation_p.S3R	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	3	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CTGAGACCCTGCTATCCATCC	0.512			NA											30	141					0	0	0.008361	0	0
CACNA1C	775	broad.mit.edu	37	12	2602428	2602428	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:2602428C>T	uc009zdu.1	+	7	1302	c.989C>T	c.(988-990)ACG>ATG	p.T330M	CACNA1C_uc009zdv.1_Missense_Mutation_p.T327M|CACNA1C_uc001qkb.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkc.2_Missense_Mutation_p.T330M|CACNA1C_uc001qke.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkf.2_Missense_Mutation_p.T330M|CACNA1C_uc001qjz.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkd.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkg.2_Missense_Mutation_p.T330M|CACNA1C_uc009zdw.1_Missense_Mutation_p.T330M|CACNA1C_uc001qkh.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkl.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkn.2_Missense_Mutation_p.T330M|CACNA1C_uc001qko.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkp.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkr.2_Missense_Mutation_p.T330M|CACNA1C_uc001qku.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkq.2_Missense_Mutation_p.T330M|CACNA1C_uc001qks.2_Missense_Mutation_p.T330M|CACNA1C_uc001qkt.2_Missense_Mutation_p.T330M|CACNA1C_uc001qka.1_Translation_Start_Site|CACNA1C_uc001qki.1_Missense_Mutation_p.T66M|CACNA1C_uc001qkj.1_Missense_Mutation_p.T66M|CACNA1C_uc001qkk.1_Missense_Mutation_p.T66M|CACNA1C_uc001qkm.1_Missense_Mutation_p.T66M	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	330	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAGAACGGCACGGTGTGCAAG	0.587			NA											43	74					0	0	0.002222	0	0
AKAP3	10566	broad.mit.edu	37	12	4736204	4736204	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:4736204C>A	uc001qnb.3	-	4	2093	c.1864G>T	c.(1864-1866)GTT>TTT	p.V622F		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	622					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						TCTTCCTTAACTGGCTGTTCC	0.502			NA											46	8					5.20006e-24	1.00745e-23	0.002852	1	0
CD163L1	283316	broad.mit.edu	37	12	7559354	7559354	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:7559354G>T	uc001qsy.2	-	5	887	c.861C>A	c.(859-861)TGC>TGA	p.C287*	CD163L1_uc010sge.1_Nonsense_Mutation_p.C297*	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	287	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ACTTATGGTGGCATACGGTCC	0.498			NA											53	69					5.22555e-25	1.02063e-24	0.00361	1	0
TAS2R42	353164	broad.mit.edu	37	12	11338969	11338969	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:11338969G>T	uc001qzr.1	-	1	575	c.575C>A	c.(574-576)CCC>CAC	p.P192H	PRB4_uc001qzf.1_Intron	NM_181429	NP_852094	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	192	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			CAGAGAAAAGGGGATAAAACT	0.348	Melanoma(15;352 722 10077 19546 48810)		NA											32	44					2.85442e-18	5.23401e-18	0.002096	1	0
PTPRO	5800	broad.mit.edu	37	12	15637129	15637129	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:15637129G>T	uc001rcv.1	+	2	471	c.297G>T	c.(295-297)GTG>GTT	p.V99V	PTPRO_uc001rcw.1_Silent_p.V99V|PTPRO_uc001rcu.1_Silent_p.V99V	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	99	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CTCTGGTAGTGGTAAATGGAA	0.383			NA											18	7					9.16793e-09	1.35262e-08	0.00499	1	0
CAPZA3	93661	broad.mit.edu	37	12	18891912	18891912	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:18891912A>T	uc001rdy.2	+	1	868	c.710A>T	c.(709-711)CAA>CTA	p.Q237L	PLCZ1_uc001rdv.3_5'Flank|PLCZ1_uc001rdw.3_5'Flank|PLCZ1_uc010sid.1_5'Flank	NM_033328	NP_201585	Q96KX2	CAZA3_HUMAN	capping protein alpha 3	237					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			ovary(1)|central_nervous_system(1)	2	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				AACAAATTTCAAGCTGCAGTC	0.428			NA											20	50					0	0	0.008871	0	0
GYS2	2998	broad.mit.edu	37	12	21695501	21695501	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:21695501G>T	uc001rfb.2	-	13	1829	c.1574C>A	c.(1573-1575)CCC>CAC	p.P525H		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	525					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						GGTCACACTGGGGATACCCAT	0.517	Colon(149;9 1820 3690 10544 50424)		NA											30	44					4.22769e-11	6.63561e-11	0.00632	1	0
SOX5	6660	broad.mit.edu	37	12	23728774	23728774	+	Splice_Site	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:23728774T>A	uc001rfw.2	-	10	1267	c.1165_splice	c.e10-1	p.D389_splice	SOX5_uc001rfx.2_Splice_Site_p.D376_splice|SOX5_uc001rfy.2_Intron|SOX5_uc001rfv.2_Splice_Site_p.D3_splice|SOX5_uc010siv.1_Splice_Site_p.D376_splice|SOX5_uc010siw.1_Splice_Site|SOX5_uc001rfz.1_Splice_Site_p.D341_splice	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a						transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						CACTTCATCCTGCAATGATCA	0.453			NA											14	43					0	0	0.00245	0	0
OVCH1	341350	broad.mit.edu	37	12	29642559	29642559	+	Silent	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:29642559G>C	uc001rix.1	-	6	696	c.696C>G	c.(694-696)GCC>GCG	p.A232A		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	232	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GTACCTGGCAGGCGTCCATTC	0.493			NA											8	8					0	0	0.004482	0	0
CNTN1	1272	broad.mit.edu	37	12	41323651	41323651	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:41323651G>T	uc001rmm.1	+	7	663	c.550G>T	c.(550-552)GAT>TAT	p.D184Y	CNTN1_uc009zjy.1_Missense_Mutation_p.D184Y|CNTN1_uc001rmn.1_Missense_Mutation_p.D173Y|CNTN1_uc001rmo.2_Missense_Mutation_p.D184Y	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	184	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TATCACAATGGATAAACGGCG	0.383			NA											29	82					4.87955e-14	8.0542e-14	0.005443	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43833464	43833464	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:43833464G>T	uc010skx.1	-	18	2554	c.2554C>A	c.(2554-2556)CCC>ACC	p.P852T	ADAMTS20_uc001rno.1_Missense_Mutation_p.P6T|ADAMTS20_uc001rnp.1_Missense_Mutation_p.P6T	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	852	TSP type-1 2.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGTCCATAGGGGTCCCATGTG	0.433			NA											37	62					2.40579e-17	4.33676e-17	0.00623	1	0
FAM113B	91523	broad.mit.edu	37	12	47629611	47629611	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:47629611G>A	uc001rpn.2	+	4	1496	c.765G>A	c.(763-765)GAG>GAA	p.E255E	FAM113B_uc010slj.1_Silent_p.E135E|FAM113B_uc001rpq.2_Silent_p.E255E	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	255							hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					GGGGTGTGGAGCTGCCCCACC	0.627			NA											4	8					0	0	0.000248	0	0
DNAJC22	79962	broad.mit.edu	37	12	49743390	49743390	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:49743390A>G	uc001rua.2	+	2	1136	c.735A>G	c.(733-735)CTA>CTG	p.L245L	DNAJC22_uc001rub.2_Silent_p.L245L	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	245					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						TCTGGAGGCTACTGATGGGGG	0.522			NA											68	100					0	0	0.00361	0	0
SCN8A	6334	broad.mit.edu	37	12	52159490	52159490	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:52159490C>A	uc001ryw.2	+	16	2758	c.2580C>A	c.(2578-2580)ACC>ACA	p.T860T	SCN8A_uc010snl.1_Silent_p.T725T|SCN8A_uc001ryy.2_Silent_p.T725T	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	860	Helical; Voltage-sensor; Name=S4 of repeat II; (Potential).|II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCTGGCCCACCCTGAACATGC	0.438			NA											14	20					2.32078e-09	3.51601e-09	0.003163	1	0
ACVR1B	91	broad.mit.edu	37	12	52370313	52370313	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:52370313G>A	uc001rzn.2	+	3	576	c.534G>A	c.(532-534)ACG>ACA	p.T178T	ACVR1B_uc001rzl.2_Silent_p.T178T|ACVR1B_uc001rzm.2_Silent_p.T178T|ACVR1B_uc010snn.1_Silent_p.T178T	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	178	Cytoplasmic (Potential).|GS.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	AAGACAAGACGCTCCAGGATC	0.488			NA											56	82					0	0	0.00361	0	0
KRT1	3848	broad.mit.edu	37	12	53070126	53070126	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:53070126T>G	uc001sau.1	-	7	1467	c.1408A>C	c.(1408-1410)AAC>CAC	p.N470H	KRT1_uc001sav.1_Missense_Mutation_p.N470H	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	470	Rod.|Coil 2.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						AGCTTTGTGTTCATCAGCTCC	0.592			NA											10	52					0	0	0.006214	0	0
ESPL1	9700	broad.mit.edu	37	12	53663153	53663153	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:53663153G>A	uc001sck.2	+	3	518	c.427G>A	c.(427-429)GTG>ATG	p.V143M	ESPL1_uc001scj.2_Translation_Start_Site	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	143					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CTATGAGGCCGTGGCTCGGGG	0.622	Colon(53;1069 1201 2587 5382)		NA											33	60					0	0	0.002836	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54928933	54928933	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:54928933T>A	uc001sgc.3	+	27	2987	c.2908T>A	c.(2908-2910)TGT>AGT	p.C970S	NCKAP1L_uc010sox.1_Missense_Mutation_p.C512S|NCKAP1L_uc010soy.1_Missense_Mutation_p.C920S	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	970					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						AGGTGTGGGCTGTGACATTGA	0.507			NA											32	52					0	0	0.004878	0	0
LRP1	4035	broad.mit.edu	37	12	57573738	57573738	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:57573738G>T	uc001snd.2	+	30	5606	c.5140G>T	c.(5140-5142)GGG>TGG	p.G1714W		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1714	LDL-receptor class B 15.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCTCTGCGTGGGTCAGTCTA	0.637			NA											49	76					1.86633e-21	3.55122e-21	0.00361	1	0
KIF5A	3798	broad.mit.edu	37	12	57966495	57966495	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:57966495G>A	uc001sor.1	+	15	1910	c.1702G>A	c.(1702-1704)GGG>AGG	p.G568R	KIF5A_uc010srr.1_Missense_Mutation_p.G479R	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	568					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						TGTGGGCAACGGGGAGATTAA	0.547			NA											48	90					0	0	0.00361	0	0
KIF5A	3798	broad.mit.edu	37	12	57970645	57970645	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:57970645C>A	uc001sor.1	+	20	2508	c.2300C>A	c.(2299-2301)ACA>AAA	p.T767K	KIF5A_uc010srr.1_Missense_Mutation_p.T678K	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	767					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CAGGAGCTGACGTGAGTGGCA	0.493			NA											15	23					0.000308642	0.000399983	0.003163	1	0
AGAP2	116986	broad.mit.edu	37	12	58124303	58124303	+	Silent	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:58124303C>G	uc001spq.2	-	12	2403	c.2403G>C	c.(2401-2403)CGG>CGC	p.R801R	AGAP2_uc001spp.2_Silent_p.R800R|AGAP2_uc001spr.2_Silent_p.R465R	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	801	PH.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						GGGCCAAATTCCGGTCTGGCT	0.572			NA											128	195					0	0	0.00361	0	0
CYP27B1	1594	broad.mit.edu	37	12	58158323	58158323	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:58158323G>C	uc001spz.1	-	6	1126	c.974C>G	c.(973-975)ACG>AGG	p.T325R	CYP27B1_uc001sqa.1_Missense_Mutation_p.T90R|CYP27B1_uc001sqb.1_Missense_Mutation_p.H205Q|CYP27B1_uc001sqc.1_3'UTR	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	325					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	CCAAGAGAGCGTGTTGGACAC	0.567			NA											5	136					0	0	0.000602	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041112	64041112	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:64041112C>G	uc001srp.1	-	5	803	c.622G>C	c.(622-624)GGA>CGA	p.G208R	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	208	Helical; (Potential).				multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TTCATTATTCCCATGAATGTG	0.318			NA											55	58					0	0	0.00361	0	0
CAND1	55832	broad.mit.edu	37	12	67688923	67688923	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:67688923G>A	uc001stn.2	+	4	915	c.478G>A	c.(478-480)GAT>AAT	p.D160N		NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	160	HEAT 4.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TATTATGGCTGATATGTTGAG	0.343			NA											7	55					0	0	0.001984	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80189444	80189444	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:80189444T>C	uc001syz.2	-	18	2824	c.2557A>G	c.(2557-2559)ACA>GCA	p.T853A	PPP1R12A_uc010suc.1_Missense_Mutation_p.T766A|PPP1R12A_uc001sza.2_Missense_Mutation_p.T797A|PPP1R12A_uc010sud.1_Missense_Mutation_p.T853A|PPP1R12A_uc001szb.2_Missense_Mutation_p.T853A	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	853	Interaction with ROCK2.					contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						GAAACTCCTGTAGATCTTCTT	0.224			NA											77	76					0	0	0.00361	0	0
PPFIA2	8499	broad.mit.edu	37	12	81777829	81777829	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:81777829G>T	uc001szo.1	-	9	1118	c.957C>A	c.(955-957)AAC>AAA	p.N319K	PPFIA2_uc010sue.1_Missense_Mutation_p.N219K|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	245										ovary(3)|lung(2)|pancreas(1)	6						GATACTTGGTGTTCATTTCTT	0.423			NA											11	18					2.80697e-09	4.23919e-09	0.000978	1	0
TRPV4	59341	broad.mit.edu	37	12	110230574	110230574	+	Silent	SNP	T	T	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:110230574T>G	uc001tpj.1	-	10	1802	c.1707A>C	c.(1705-1707)GCA>GCC	p.A569A	TRPV4_uc001tpg.1_Silent_p.A535A|TRPV4_uc001tph.1_Silent_p.A522A|TRPV4_uc001tpi.1_Silent_p.A462A|TRPV4_uc001tpk.1_Silent_p.A569A|TRPV4_uc001tpl.1_Silent_p.A509A	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	569	Helical; (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CCTCGATCCCTGCCAGGTAGA	0.587			NA											10	33					0	0	0.006214	0	0
CUX2	23316	broad.mit.edu	37	12	111748231	111748231	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:111748231G>T	uc001tsa.1	+	15	1798	c.1645G>T	c.(1645-1647)GAG>TAG	p.E549*		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	549	CUT 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCCCGGGGCAGAGGAGGAGCA	0.711			NA											8	8					7.48243e-07	1.05369e-06	0.006214	1	0
PTPN11	5781	broad.mit.edu	37	12	112915664	112915664	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:112915664G>T	uc001ttx.2	+	9	1317	c.937G>T	c.(937-939)GAA>TAA	p.E313*	PTPN11_uc001ttw.1_Nonsense_Mutation_p.E313*	NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	313	Tyrosine-protein phosphatase.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						TTTCTAGCCTGAATTTGAAAC	0.378			NA	Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				18	23					3.99206e-14	6.63498e-14	0.007413	1	0
IQCD	115811	broad.mit.edu	37	12	113645859	113645859	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:113645859A>G	uc001tuv.1	-	2	535	c.113T>C	c.(112-114)GTT>GCT	p.V38A	IQCD_uc001tuu.2_Missense_Mutation_p.V38A	NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	38										ovary(1)	1						CCTAGAGAGAACCAAGGGTTT	0.512			NA											67	143					0	0	0.00361	0	0
NOS1	4842	broad.mit.edu	37	12	117768862	117768862	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:117768862T>C	uc001twm.1	-	2	699	c.13A>G	c.(13-15)ATG>GTG	p.M5V		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	5	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ACACCGAACATGTGATCCTCC	0.517	Esophageal Squamous(162;1748 2599 51982 52956)		NA											32	69					0	0	0.005524	0	0
CIT	11113	broad.mit.edu	37	12	120295395	120295395	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:120295395C>A	uc001txi.1	-	4	399	c.346G>T	c.(346-348)GAG>TAG	p.E116*	CIT_uc001txj.1_Nonsense_Mutation_p.E116*	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	116	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GTTGCTTTCTCTCTTACCACC	0.473			NA											55	156					2.22609e-26	4.43829e-26	0.00361	1	0
WDR66	144406	broad.mit.edu	37	12	122395035	122395035	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:122395035T>C	uc009zxk.2	+	11	1733	c.1591T>C	c.(1591-1593)TCT>CCT	p.S531P		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	531	WD 5.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		TCACACCCTGTCTATTGTTAA	0.388	Esophageal Squamous(85;849 1794 49757 52143)		NA											46	34					0	0	0.00361	0	0
LRRC43	254050	broad.mit.edu	37	12	122676103	122676103	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:122676103G>A	uc009zxm.2	+	6	1103	c.1078G>A	c.(1078-1080)GTC>ATC	p.V360I	LRRC43_uc001ubw.3_Missense_Mutation_p.V175I|LRRC43_uc009zxn.2_Missense_Mutation_p.V121I	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	360	Glu-rich.										0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		GTCCGCGGGCGTCCTGGCCGA	0.517			NA									OREG0022219	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	47					0	0	0.00333	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184559	130184559	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:130184559C>A	uc009zyl.1	-	2	1092	c.764G>T	c.(763-765)AGT>ATT	p.S255I		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	255	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATCGATGTCACTGTGGCCTGT	0.602			NA											13	56					0.000219431	0.000285917	0.00245	1	0
GPR133	283383	broad.mit.edu	37	12	131456050	131456050	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:131456050A>G	uc001uit.3	+	4	794	c.235A>G	c.(235-237)AAG>GAG	p.K79E	GPR133_uc010tbm.1_Missense_Mutation_p.K111E	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	79	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAAAGAGGAAAAGGGAGTCAC	0.463			NA											4	44					0	0	0.001168	0	0
ZNF268	10795	broad.mit.edu	37	12	133779036	133779036	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:133779036G>T	uc010tcf.1	+	6	1094	c.764G>T	c.(763-765)GGA>GTA	p.G255V	ZNF268_uc010tbv.1_Missense_Mutation_p.G94V|ZNF268_uc010tbw.1_Missense_Mutation_p.G94V|ZNF268_uc010tbx.1_Missense_Mutation_p.G115V|ZNF268_uc010tby.1_Missense_Mutation_p.G94V|ZNF268_uc010tbz.1_Missense_Mutation_p.G94V|ZNF268_uc010tca.1_Missense_Mutation_p.G94V|ZNF268_uc010tcb.1_Missense_Mutation_p.G115V|ZNF268_uc010tcc.1_Missense_Mutation_p.G94V|ZNF268_uc010tcd.1_Missense_Mutation_p.G94V|ZNF268_uc010tce.1_Missense_Mutation_p.G94V|ZNF268_uc010tcg.1_Missense_Mutation_p.G94V|ZNF268_uc010tch.1_Missense_Mutation_p.G255V	NM_003415	NP_003406	Q14587	ZN268_HUMAN	zinc finger protein 268 isoform a	255						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		ATTGAATCTGGAAAAACCGTC	0.368			NA											6	10					0.00198382	0.00250656	0.001984	1	0
TUBA3C	7278	broad.mit.edu	37	13	19748237	19748237	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:19748237C>A	uc009zzj.2	-	5	1168	c.1119G>T	c.(1117-1119)CGG>CGT	p.R373R		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	373					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TGCACACAGCCCGCTGCACCT	0.602			NA											55	11					4.1673e-28	8.41357e-28	0.00361	1	0
WASF3	10810	broad.mit.edu	37	13	27256877	27256877	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:27256877G>T	uc001uqv.2	+	9	1342	c.1117G>T	c.(1117-1119)GCA>TCA	p.A373S	WASF3_uc001uqw.2_Missense_Mutation_p.A370S	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	373					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CCCGTTCCCTGCATCAGCCAG	0.697			NA											75	15					3.83446e-41	8.17165e-41	0.00361	1	0
BRCA2	675	broad.mit.edu	37	13	32913428	32913428	+	Missense_Mutation	SNP	G	G	C	rs80359473		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:32913428G>C	uc001uub.1	+	11	5163	c.4936G>C	c.(4936-4938)GAA>CAA	p.E1646Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1646					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGTAGAAAAAGAAACAGCAAA	0.303	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			3	38					0	0	0.004672	0	0
TRPC4	7223	broad.mit.edu	37	13	38213192	38213192	+	Silent	SNP	G	G	T	rs116527482	by1000genomes	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:38213192G>T	uc001uws.2	-	10	2431	c.2196C>A	c.(2194-2196)ACC>ACA	p.T732T	TRPC4_uc010abv.2_Silent_p.T312T|TRPC4_uc001uwt.2_Silent_p.T732T|TRPC4_uc010tey.1_Intron|TRPC4_uc010abw.2_Silent_p.T559T|TRPC4_uc010abx.2_Silent_p.T737T|TRPC4_uc010aby.2_Silent_p.T667T	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	732	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AGTTCTCTTCGGTCAGGCCTT	0.398			NA											100	33					3.52173e-36	7.39023e-36	0.00361	1	0
FREM2	341640	broad.mit.edu	37	13	39263534	39263534	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:39263534G>T	uc001uwv.2	+	1	2362	c.2053G>T	c.(2053-2055)GGG>TGG	p.G685W		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	685	CSPG 4.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TAATCAGTCCGGGCTACAGCG	0.557			NA											44	16					1.57945e-13	2.58923e-13	0.002852	1	0
PCDH17	27253	broad.mit.edu	37	13	58240920	58240920	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:58240920C>A	uc001vhq.1	+	3	3642	c.2750C>A	c.(2749-2751)GCA>GAA	p.A917E	PCDH17_uc010aec.1_Missense_Mutation_p.A916E|PCDH17_uc001vhr.1_Missense_Mutation_p.A6E	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	917	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GTTAGGGAGGCACTCAAGATG	0.463	Melanoma(72;952 1291 1619 12849 33676)		NA											14	27					0.00244969	0.00309113	0.00245	1	0
DIAPH3	81624	broad.mit.edu	37	13	60616906	60616906	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:60616906C>A	uc001vht.2	-	5	763	c.544G>T	c.(544-546)GAG>TAG	p.E182*	DIAPH3_uc001vhw.1_Nonsense_Mutation_p.E171*|DIAPH3_uc010aed.1_Nonsense_Mutation_p.E136*|DIAPH3_uc010aee.1_Nonsense_Mutation_p.E112*|uc001vhx.2_RNA	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	182	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		ATTTTCAGCTCATGAATGAAT	0.408			NA											9	34					7.48243e-07	1.05369e-06	0.006214	1	0
POU4F1	5457	broad.mit.edu	37	13	79177363	79177363	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:79177363C>A	uc001vkv.2	-	1	333	c.99G>T	c.(97-99)CGG>CGT	p.R33R	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	33					axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		GGCAGGCCCGCCGGATGGCCT	0.522	Melanoma(109;347 2166 14574 42843)|Ovarian(81;1394 1854 22417 48351)		NA											8	12					1.06961e-07	1.54482e-07	0.00308	1	0
POU4F1	5457	broad.mit.edu	37	13	79177376	79177376	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:79177376G>A	uc001vkv.2	-	1	320	c.86C>T	c.(85-87)TCC>TTC	p.S29F	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	29					axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		GATGGCCTCGGAGCTGGAGTG	0.522	Melanoma(109;347 2166 14574 42843)|Ovarian(81;1394 1854 22417 48351)		NA											14	14					0	0	0.003163	0	0
TPP2	7174	broad.mit.edu	37	13	103249310	103249310	+	Translation_Start_Site	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:103249310G>T	uc001vpi.3	+	1	25	c.-78G>T	c.(-80--76)GAGGC>GATGC			NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II						proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCCGGCCCGAGGCCGCACGGG	0.711			NA											6	3					3.59834e-05	4.77951e-05	0.001168	1	0
TMCO3	55002	broad.mit.edu	37	13	114154387	114154387	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:114154387G>A	uc001vtu.3	+	4	1100	c.739G>A	c.(739-741)GAC>AAC	p.D247N	TMCO3_uc001vtt.3_Missense_Mutation_p.D247N	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	247						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			CATGCTGATTGACTCCCAGAA	0.453			NA											18	37					0	0	0.00499	0	0
ZNF828	283489	broad.mit.edu	37	13	115091622	115091622	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr13:115091622C>T	uc010ahb.2	+	3	2634	c.2305C>T	c.(2305-2307)CGT>TGT	p.R769C	ZNF828_uc001vuv.2_Missense_Mutation_p.R769C|ZNF828_uc010tko.1_Missense_Mutation_p.R769C	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	769	Mediates localization to the chromosome and the spindle and negatively regulates chromosome alignment.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		TAAATGTCCACGTTGTAATTT	0.363			NA											28	22					0	0	0.004656	0	0
OR4L1	122742	broad.mit.edu	37	14	20528618	20528618	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:20528618A>T	uc001vwn.1	+	1	415	c.415A>T	c.(415-417)AAG>TAG	p.K139*		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		CATGAGCCACAAGCTGCTAAA	0.423			NA											21	99					0	0	0.001523	0	0
OR4N5	390437	broad.mit.edu	37	14	20612807	20612807	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:20612807C>A	uc010tla.1	+	1	913	c.913C>A	c.(913-915)CAT>AAT	p.H305N		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GTTAAGTCAACATATGTTTTG	0.363			NA											53	26					6.18754e-15	1.0521e-14	0.00361	1	0
OR11H6	122748	broad.mit.edu	37	14	20692796	20692796	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:20692796C>T	uc010tlc.1	+	1	928	c.928C>T	c.(928-930)CTT>TTT	p.L310F		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	310	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TATCTATAGTCTTCGAAACAA	0.418			NA											102	40					0	0	0.00361	0	0
RNASE11	122651	broad.mit.edu	37	14	21052362	21052362	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:21052362G>T	uc010ahv.2	-	2	457	c.272C>A	c.(271-273)TCG>TAG	p.S91*	RNASE11_uc010ahx.2_Nonsense_Mutation_p.S91*|RNASE11_uc010ahw.2_Nonsense_Mutation_p.S91*|RNASE11_uc001vxs.2_Nonsense_Mutation_p.S91*	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	91						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		GTCATTACCCGAACTGTTTCC	0.418			NA											123	61					2.79849e-55	6.0856e-55	0.00361	1	0
RAB2B	84932	broad.mit.edu	37	14	21930549	21930549	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:21930549T>G	uc010tlt.1	-	7	604	c.503A>C	c.(502-504)TAT>TCT	p.Y168S	RAB2B_uc010tls.1_Missense_Mutation_p.Y122S|RAB2B_uc001wax.2_Missense_Mutation_p.Y103S|RAB2B_uc010ain.2_Missense_Mutation_p.Y59S	NM_032846	NP_116235	Q8WUD1	RAB2B_HUMAN	RAB2B protein isoform 1	168				Y -> H (in Ref. 1; AAN86142).	protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			ovary(1)	1	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		GATCTTCCTATATATTTCTTT	0.383	Melanoma(131;1007 1750 28652 34486 42672)		NA											36	86					0	0	0.007835	0	0
PRMT5	10419	broad.mit.edu	37	14	23390185	23390185	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:23390185C>A	uc001whm.1	-	17	1933	c.1842G>T	c.(1840-1842)GAG>GAT	p.E614D	RBM23_uc001whh.2_5'Flank|RBM23_uc001whg.2_5'Flank|RBM23_uc001whi.2_5'Flank|RBM23_uc010tne.1_5'Flank|RBM23_uc001whj.2_5'Flank|RBM23_uc001whk.1_5'Flank|PRMT5_uc001whl.1_Missense_Mutation_p.E597D|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_Missense_Mutation_p.E508D|PRMT5_uc010tng.1_Missense_Mutation_p.E553D|PRMT5_uc010tnh.1_Missense_Mutation_p.E570D|PRMT5_uc001whn.1_Missense_Mutation_p.E443D	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	614					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TCACAGCCCACTCATACCACA	0.527			NA											17	56					9.16793e-09	1.35262e-08	0.00499	1	0
CTSG	1511	broad.mit.edu	37	14	25042852	25042852	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:25042852G>T	uc001wpq.2	-	5	796	c.759C>A	c.(757-759)ACC>ACA	p.T253T		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	253					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		GTCACAGGGGGGTCTCCATCT	0.502			NA											153	84					5.63807e-81	1.24012e-80	0.00361	1	0
NOVA1	4857	broad.mit.edu	37	14	26917495	26917495	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:26917495A>G	uc001wpy.2	-	5	1512	c.1194T>C	c.(1192-1194)TAT>TAC	p.Y398Y	NOVA1_uc001wpz.2_Silent_p.Y374Y|NOVA1_uc001wqa.2_Silent_p.Y276Y	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	401	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CAGCTCCAAAATATCCATTGG	0.517			NA											11	44					0	0	0.000978	0	0
CTAGE5	4253	broad.mit.edu	37	14	39790155	39790155	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:39790155C>A	uc001wvg.3	+	19	1903	c.1567C>A	c.(1567-1569)CCA>ACA	p.P523T	CTAGE5_uc010tqe.1_Missense_Mutation_p.P485T|CTAGE5_uc001wuz.3_Missense_Mutation_p.P511T|CTAGE5_uc001wuy.3_Missense_Mutation_p.P443T|CTAGE5_uc001wvb.3_Intron|CTAGE5_uc001wvc.3_Intron|CTAGE5_uc001wva.3_Missense_Mutation_p.P494T|CTAGE5_uc001wvh.3_Intron|CTAGE5_uc001wvf.3_Missense_Mutation_p.P448T|CTAGE5_uc001wvi.3_Missense_Mutation_p.P528T|CTAGE5_uc010amz.2_Missense_Mutation_p.P139T|CTAGE5_uc001wvj.3_Missense_Mutation_p.P494T	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	523	Pro-rich.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TGGTCCCTCACCATTGGGTTG	0.443			NA											24	106					5.61819e-17	1.00146e-16	0.005443	1	0
MDGA2	161357	broad.mit.edu	37	14	47504236	47504236	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:47504236G>T	uc001wwj.3	-	8	1786	c.1590C>A	c.(1588-1590)GCC>GCA	p.A530A	MDGA2_uc001wwi.3_Silent_p.A301A|MDGA2_uc010ani.2_Silent_p.A90A	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	530	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GCTGCACCAAGGCTTCCCTTG	0.398			NA											12	116					1.3612e-06	1.90014e-06	0.003163	1	0
DACT1	51339	broad.mit.edu	37	14	59113481	59113481	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:59113481G>T	uc001xdw.2	+	4	2304	c.2140G>T	c.(2140-2142)GCC>TCC	p.A714S	DACT1_uc010trv.1_Missense_Mutation_p.A433S|DACT1_uc001xdx.2_Missense_Mutation_p.A677S|DACT1_uc010trw.1_Missense_Mutation_p.A433S	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	714					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						TCTGCCCTACGCCAGCCCCTA	0.677			NA											42	7					8.01111e-26	1.57431e-25	0.002522	1	0
RHOJ	57381	broad.mit.edu	37	14	63671684	63671684	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:63671684G>T	uc001xgb.1	+	1	540	c.97G>T	c.(97-99)GGG>TGG	p.G33W		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	ras homolog gene family, member J precursor	33	GTP (By similarity).				actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		CGGTGCCGTGGGGAAAACCTG	0.547			NA											30	12					3.90053e-15	6.66775e-15	0.002445	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68222835	68222835	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:68222835C>A	uc001xka.2	-	36	6755	c.6616G>T	c.(6616-6618)GGC>TGC	p.G2206C	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkb.2_Missense_Mutation_p.G52C	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2206					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TGGAAAATGCCTTCTATAAAA	0.473			NA											251	68					1.7865e-107	3.93852e-107	0.00361	1	0
PAPLN	89932	broad.mit.edu	37	14	73719443	73719443	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:73719443C>A	uc010ttx.1	+	10	1217	c.1054C>A	c.(1054-1056)CGG>AGG	p.R352R	PAPLN_uc001xnw.3_Silent_p.R325R|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Silent_p.R352R	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	352	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCCAGCTGACCGGCGTTCCTG	0.642			NA											49	56					2.43277e-16	4.25735e-16	0.00361	1	0
C14orf174	161394	broad.mit.edu	37	14	77844926	77844926	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:77844926C>G	uc001xtq.1	+	1	1165	c.1165C>G	c.(1165-1167)CCA>GCA	p.P389A	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	389											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GGAGATCAACCCACAAGTTGA	0.413			NA											21	48					0	0	0.001523	0	0
ALKBH1	8846	broad.mit.edu	37	14	78140172	78140172	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:78140172T>A	uc001xuc.1	-	6	1162	c.1153A>T	c.(1153-1155)ATA>TTA	p.I385L	ALKBH1_uc001xud.1_RNA	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog	385					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		TCAGGGTTTATCCTGGCCCGT	0.453			NA											37	24					0	0	0.005524	0	0
KCNK13	56659	broad.mit.edu	37	14	90650517	90650517	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:90650517G>T	uc001xye.1	+	2	839	c.397G>T	c.(397-399)GTT>TTT	p.V133F		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	133	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TTACGGCCTTGTTGGGTGTTC	0.502			NA											80	23					1.75807e-36	3.70547e-36	0.00361	1	0
SLC24A4	123041	broad.mit.edu	37	14	92959890	92959890	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:92959890C>A	uc001yak.2	+	17	1760	c.1736C>A	c.(1735-1737)GCC>GAC	p.A579D	SLC24A4_uc001yai.2_Missense_Mutation_p.A532D|SLC24A4_uc010twm.1_Missense_Mutation_p.A577D|SLC24A4_uc001yaj.2_Missense_Mutation_p.A560D|SLC24A4_uc010auj.2_3'UTR|SLC24A4_uc010twn.1_Missense_Mutation_p.A352D|SLC24A4_uc001yan.2_Missense_Mutation_p.A290D	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	596	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GTTCTCTACGCCATCTTCTTG	0.547	NSCLC(10;315 435 10383 28450 38798)		NA											47	12					2.24722e-20	4.23396e-20	0.00361	1	0
KIAA1409	57578	broad.mit.edu	37	14	94053228	94053228	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:94053228C>A	uc001ybv.1	+	19	2558	c.2475C>A	c.(2473-2475)TAC>TAA	p.Y825*	KIAA1409_uc001ybs.1_Nonsense_Mutation_p.Y825*	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1002						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTTTAGCCTACATTCAGGACC	0.343			NA											124	37					3.78446e-69	8.28607e-69	0.00361	1	0
SERPINA5	5104	broad.mit.edu	37	14	95053813	95053813	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:95053813C>A	uc001ydm.2	+	3	324	c.114C>A	c.(112-114)GCC>GCA	p.A38A	SERPINA5_uc010ave.2_Silent_p.A38A|SERPINA5_uc001ydn.1_Silent_p.A38A	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	38					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	ATGTAGGTGCCACGGTGGCCC	0.622			NA											52	14					6.81593e-30	1.39371e-29	0.00361	1	0
TDRD9	122402	broad.mit.edu	37	14	104441747	104441747	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:104441747A>G	uc001yom.3	+	7	898	c.868A>G	c.(868-870)ATC>GTC	p.I290V	TDRD9_uc001yon.3_Missense_Mutation_p.I28V	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	290	Helicase ATP-binding.				cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				GTCGGCTACCATCAGCTGTAA	0.378			NA											4	72					0	0	0.000602	0	0
KIF26A	26153	broad.mit.edu	37	14	104640563	104640563	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:104640563G>T	uc001yos.3	+	11	2109	c.2109G>T	c.(2107-2109)TCG>TCT	p.S703S		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	703					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCCACGTGTCGGATGCGCCAG	0.682			NA											10	5					0.000442599	0.000570501	0.006214	1	0
MTA1	9112	broad.mit.edu	37	14	105929519	105929519	+	Splice_Site	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr14:105929519A>G	uc001yqx.2	+	11	1130	c.943_splice	c.e11-2	p.L315_splice	MTA1_uc001yqy.2_Splice_Site|MTA1_uc001yrb.2_Splice_Site_p.L76_splice	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein						signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CCTCCCACCCAGCTCCCGTGG	0.647			NA											127	101					0	0	0.00361	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889722	23889722	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:23889722A>T	uc001ywj.3	-	1	1454	c.1359T>A	c.(1357-1359)GAT>GAA	p.D453E		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CTAAGCACTCATCTTTATACT	0.453			NA											26	23					0	0	0.00632	0	0
ATP10A	57194	broad.mit.edu	37	15	25924502	25924502	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:25924502T>A	uc010ayu.2	-	21	4592	c.4486A>T	c.(4486-4488)AGG>TGG	p.R1496W		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1496	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGTGACCGCCTTGAAGATGCT	0.413			NA											33	29					0	0	0.002836	0	0
APBA2	321	broad.mit.edu	37	15	29386483	29386483	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:29386483G>T	uc001zck.2	+	7	1425	c.1218G>T	c.(1216-1218)AGG>AGT	p.R406S	APBA2_uc010azj.2_Intron|APBA2_uc010uat.1_Intron|APBA2_uc001zcl.2_Intron|APBA2_uc001zcm.1_Intron	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	406	PID.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GCTGTCAGAGGATGCAAAAGG	0.507			NA											24	81					1.33986e-20	2.53438e-20	0.004656	1	0
PAK6	56924	broad.mit.edu	37	15	40564701	40564701	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:40564701G>T	uc010bbl.2	+	6	1575	c.1135G>T	c.(1135-1137)GGT>TGT	p.G379C	PAK6_uc010bbm.2_Missense_Mutation_p.G379C|PAK6_uc001zky.3_Missense_Mutation_p.G379C|PAK6_uc010bbn.2_Missense_Mutation_p.G379C|PAK6_uc001zlb.2_Missense_Mutation_p.G379C	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	379	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		TGCCCTGGCTGGTGAGGACAC	0.647			NA											9	9					7.48243e-07	1.05369e-06	0.006214	1	0
SQRDL	58472	broad.mit.edu	37	15	45968317	45968317	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:45968317G>T	uc001zvt.2	+	7	862	c.673G>T	c.(673-675)GCC>TCC	p.A225S	SQRDL_uc001zvu.2_Missense_Mutation_p.A225S|SQRDL_uc001zvv.2_Missense_Mutation_p.A225S	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	225							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		GCGATCCAAGGCCAATATCAT	0.418			NA											49	35					8.72198e-27	1.75722e-26	0.00361	1	0
SHC4	399694	broad.mit.edu	37	15	49255113	49255113	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:49255113G>T	uc001zxb.1	-	1	529	c.100C>A	c.(100-102)CGG>AGG	p.R34R		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	34	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		GACTCGTTCCGAAAGCGGCTG	0.652			NA											23	22					4.26978e-12	6.81317e-12	0.00333	1	0
SCG3	29106	broad.mit.edu	37	15	51975582	51975582	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:51975582G>T	uc002abh.2	+	4	756	c.348G>T	c.(346-348)CTG>CTT	p.L116L	SCG3_uc010ufz.1_5'UTR	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	116					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		ATCGAAAACTGATCGATGATT	0.323			NA											5	52					0.000602214	0.000770031	0.000602	1	0
GOLGA6B	55889	broad.mit.edu	37	15	72953671	72953671	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:72953671C>A	uc010uks.1	+	8	672	c.631C>A	c.(631-633)CTG>ATG	p.L211M		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	211	Potential.										0						GCGGGCGCTGCTGAACGCACA	0.592			NA											15	65					8.00594e-06	1.08749e-05	0.007413	1	0
CSPG4	1464	broad.mit.edu	37	15	75968962	75968962	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:75968962G>T	uc002baw.2	-	10	5991	c.5898C>A	c.(5896-5898)CTC>CTA	p.L1966L		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1966	Extracellular (Potential).|CSPG 14.|Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						AAACCACCCGGAGCTGCTGCT	0.672			NA											14	26					1.52009e-12	2.45415e-12	0.003163	1	0
CSPG4	1464	broad.mit.edu	37	15	75979682	75979682	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:75979682C>G	uc002baw.2	-	3	3817	c.3724G>C	c.(3724-3726)GTC>CTC	p.V1242L		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1242	CSPG 8.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TTGTGCCGGACCAGCTTCAGT	0.617			NA											18	32					0	0	0.008871	0	0
ABHD2	11057	broad.mit.edu	37	15	89738464	89738464	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:89738464G>T	uc002bnj.2	+	16	2005	c.1088G>T	c.(1087-1089)CGA>CTA	p.R363L	ABHD2_uc002bnk.2_Missense_Mutation_p.R363L	NM_007011	NP_008942	P08910	ABHD2_HUMAN	alpha/beta hydrolase domain containing protein	363						integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GCAGAGAAACGAGAGAACGTC	0.567	Colon(11;252 417 24570 33239 41878)		NA											13	40					4.3838e-07	6.22824e-07	0.001855	1	0
CLCN7	1186	broad.mit.edu	37	16	1507713	1507714	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:1507713_1507714CC>AA	uc002clv.2	-	8	829_830	c.719_720GG>TT	c.(718-720)GGG>GTT	p.G240V	CLCN7_uc002clw.2_Missense_Mutation_p.G216V	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	240	Helical; (By similarity).		G -> R (in OPTB4).			integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				CGGCCAGGCCCCCGACCACGGA	0.629			NA											6	21					0	0	0.004672	0	0
ZG16B	124220	broad.mit.edu	37	16	2880331	2880331	+	Splice_Site	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:2880331T>A	uc002cru.2	+	1	157	c.81_splice	c.e1+2	p.E27_splice		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor							extracellular region	sugar binding			ovary(1)	1						ACAGGCGAGGTAAGGTGCTTG	0.637			NA											4	6					0	0	0.001168	0	0
MEFV	4210	broad.mit.edu	37	16	3304279	3304279	+	Silent	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:3304279T>A	uc002cun.1	-	2	829	c.789A>T	c.(787-789)CTA>CTT	p.L263L		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	263					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	TCTTTTCCTCTAGAGTCAGGA	0.572			NA											39	68					0	0	0.007835	0	0
ZNF500	26048	broad.mit.edu	37	16	4815625	4815625	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:4815625C>A	uc002cxp.1	-	2	602	c.355G>T	c.(355-357)GAG>TAG	p.E119*	ZNF500_uc002cxo.1_5'UTR|ZNF500_uc010uxt.1_Nonsense_Mutation_p.E119*	NM_021646	NP_067678	O60304	ZN500_HUMAN	zinc finger protein 500	119	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						ACGGCCTCCTCACCGCTCTCC	0.647			NA											16	36					6.31663e-08	9.16436e-08	0.003163	1	0
A2BP1	54715	broad.mit.edu	37	16	7645589	7645589	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:7645589G>T	uc002cys.2	+	8	1495	c.507G>T	c.(505-507)GCG>GCT	p.A169A	A2BP1_uc010buf.1_Silent_p.A169A|A2BP1_uc002cyr.1_Silent_p.A168A|A2BP1_uc002cyt.2_Silent_p.A169A|A2BP1_uc010uxz.1_Silent_p.A212A|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Silent_p.A169A|A2BP1_uc010uyb.1_Silent_p.A169A|A2BP1_uc002cyw.2_Silent_p.A189A|A2BP1_uc002cyy.2_Silent_p.A189A|A2BP1_uc002cyx.2_Silent_p.A189A|A2BP1_uc010uyc.1_Silent_p.A189A	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	169	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		GTGCCGATGCGGACAGGGCGA	0.428			NA											28	52					5.8336e-16	1.01532e-15	0.003271	1	0
MYH11	4629	broad.mit.edu	37	16	15853483	15853483	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:15853483C>T	uc002ddy.2	-	12	1458	c.1351G>A	c.(1351-1353)GGG>AGG	p.G451R	MYH11_uc002ddv.2_Missense_Mutation_p.G458R|MYH11_uc002ddw.2_Missense_Mutation_p.G451R|MYH11_uc002ddx.2_Missense_Mutation_p.G458R|MYH11_uc010bvg.2_Missense_Mutation_p.G283R|MYH11_uc002dea.1_Missense_Mutation_p.G157R	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	451	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						AAGGAAGCCCCTTGCCGATGG	0.532			NA	T	CBFB	AML								20	59					0	0	0.008871	0	0
ABCC1	4363	broad.mit.edu	37	16	16184348	16184348	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:16184348G>T	uc010bvi.2	+	19	2722	c.2547G>T	c.(2545-2547)ATG>ATT	p.M849I	ABCC1_uc010bvj.2_Missense_Mutation_p.M790I|ABCC1_uc010bvk.2_Missense_Mutation_p.M793I|ABCC1_uc010bvl.2_Missense_Mutation_p.M849I|ABCC1_uc010bvm.2_Missense_Mutation_p.M734I|ABCC1_uc002del.3_Missense_Mutation_p.M733I	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	849	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCTCTGAGATGGGCTCCTACC	0.597			NA											6	9					2.0095e-06	2.76883e-06	0.001984	1	0
C16orf62	57020	broad.mit.edu	37	16	19644488	19644488	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:19644488C>T	uc002dgn.1	+	19	1641	c.1629C>T	c.(1627-1629)TAC>TAT	p.Y543Y	C16orf62_uc002dgo.1_Silent_p.Y476Y|C16orf62_uc002dgp.1_Silent_p.Y292Y	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	543						integral to membrane				ovary(1)	1						AAGATTCCTACCCCCAGGTAA	0.368			NA											30	59					0	0	0.002836	0	0
METTL9	51108	broad.mit.edu	37	16	21623972	21623972	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:21623972G>A	uc002dje.2	+	2	371	c.172G>A	c.(172-174)GTG>ATG	p.V58M	uc002diq.3_Intron|METTL9_uc002djf.2_Missense_Mutation_p.V58M	NM_016025	NP_057109	Q9H1A3	METL9_HUMAN	methyltransferase like 9 isoform 1	58										ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0759)		ttAGTGGTATGTGTGCAACAG	0.323			NA											10	22					0	0	0.006214	0	0
OTOA	146183	broad.mit.edu	37	16	21716560	21716560	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:21716560T>A	uc002djh.2	+	11	1052	c.1051T>A	c.(1051-1053)TAC>AAC	p.Y351N	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.Y272N|OTOA_uc002dji.2_Missense_Mutation_p.Y27N|OTOA_uc010vbk.1_5'UTR	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	365					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		AGTCCTGCTTTACCAGATGAT	0.572			NA											31	50					0	0	0.002096	0	0
CD19	930	broad.mit.edu	37	16	28947869	28947869	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:28947869C>A	uc002drs.2	+	7	1094	c.1032C>A	c.(1030-1032)CCC>CCA	p.P344P	uc010vct.1_Intron|CD19_uc010byo.1_Silent_p.P344P	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	344	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						GAAGCGGGCCCCAGAACCAGT	0.637			NA											12	57					1.5842e-08	2.31593e-08	0.001855	1	0
SALL1	6299	broad.mit.edu	37	16	51171110	51171110	+	Silent	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:51171110G>C	uc010vgs.1	-	3	3919	c.3888C>G	c.(3886-3888)GGC>GGG	p.G1296G	SALL1_uc010vgr.1_Silent_p.G1199G|SALL1_uc010cbv.2_Silent_p.G148G	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1296					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TTTTCTCCAGGCCGGCCAGGG	0.587	GBM(103;1352 1446 1855 4775 8890)		NA											16	38					0	0	0.003163	0	0
HYDIN	54768	broad.mit.edu	37	16	70908286	70908286	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:70908286G>T	uc002ezr.2	-	64	10995	c.10867C>A	c.(10867-10869)CCC>ACC	p.P3623T		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3624										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGGCTGGTGGGGGCCACCAGT	0.502			NA											12	50					3.45872e-05	4.60682e-05	0.004007	1	0
HYDIN	54768	broad.mit.edu	37	16	71015345	71015345	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:71015345C>A	uc002ezr.2	-	29	4584	c.4456G>T	c.(4456-4458)GGA>TGA	p.G1486*		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1487										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATTCCCTCTCCGCTCAGAGTG	0.478			NA											18	39					7.16444e-05	9.43777e-05	0.003954	1	0
CHST4	10164	broad.mit.edu	37	16	71571596	71571596	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:71571596C>A	uc002fan.2	+	2	1197	c.1016C>A	c.(1015-1017)CCC>CAC	p.P339H	CHST4_uc002fao.2_Missense_Mutation_p.P339H	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	339	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						TGGTCTTTGCCCTATGAAAAG	0.527			NA									OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	20					1.76689e-08	2.57515e-08	0.006214	1	0
GLG1	2734	broad.mit.edu	37	16	74516969	74516969	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:74516969C>G	uc002fcy.3	-	10	1675	c.1625G>C	c.(1624-1626)TGT>TCT	p.C542S	GLG1_uc002fcx.2_Missense_Mutation_p.C542S|GLG1_uc002fcw.3_Missense_Mutation_p.C531S|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	542	Extracellular (Potential).|Cys-rich GLG1 8.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						ACGGTGTTCACAGTCTTCTAC	0.413			NA											28	37					0	0	0.003755	0	0
CHST5	23563	broad.mit.edu	37	16	75563627	75563627	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:75563627A>G	uc002fei.2	-	3	2051	c.656T>C	c.(655-657)ATC>ACC	p.I219T	CHST5_uc002fej.1_Missense_Mutation_p.I225T	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	219	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CAGGTGCACGATGCGCAGGTT	0.706			NA											21	37					0	0	0.001523	0	0
OSGIN1	29948	broad.mit.edu	37	16	83999445	83999445	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:83999445A>G	uc002fha.2	+	7	1899	c.1516A>G	c.(1516-1518)AAG>GAG	p.K506E	NECAB2_uc002fhd.2_5'Flank|OSGIN1_uc002fhb.2_Missense_Mutation_p.K423E|OSGIN1_uc002fhc.2_Missense_Mutation_p.K423E	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	506					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						GCTGAGCGCCAAGAGGAACCC	0.662			NA											33	17					0	0	0.00623	0	0
PITPNM3	83394	broad.mit.edu	37	17	6364774	6364774	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:6364774C>A	uc002gdd.3	-	18	2560	c.2409G>T	c.(2407-2409)CAG>CAT	p.Q803H	PITPNM3_uc010cln.2_Missense_Mutation_p.Q767H|PITPNM3_uc010clm.2_Missense_Mutation_p.Q286H|PITPNM3_uc002gdc.3_Missense_Mutation_p.Q394H	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	803					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		AGATCATGCCCTGTGGGAAGT	0.607			NA											76	19					3.00167e-28	6.073e-28	0.00361	1	0
TP53	7157	broad.mit.edu	37	17	7577129	7577129	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:7577129A>C	uc002gim.2	-	8	1003	c.809T>G	c.(808-810)TTT>TGT	p.F270C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.F270C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.F138C|TP53_uc010cng.1_Missense_Mutation_p.F138C|TP53_uc002gii.1_Missense_Mutation_p.F138C|TP53_uc010cnh.1_Missense_Mutation_p.F270C|TP53_uc010cni.1_Missense_Mutation_p.F270C|TP53_uc002gij.2_Missense_Mutation_p.F270C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	270	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		F -> L (in sporadic cancers; somatic mutation).|F -> Y (in sporadic cancers; somatic mutation).|F -> C (in sporadic cancers; somatic mutation).|F -> V (in sporadic cancers; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.F270L(22)|p.F270C(15)|p.F270V(8)|p.0?(7)|p.F270S(7)|p.F270Y(5)|p.F270I(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.G262_F270delGNLLGRNSF(2)|p.F270fs*72(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.S269fs*34(1)|p.F270_D281del12(1)|p.S269_F270insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACGCACCTCAAAGCTGTTCCG	0.537	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	6					0	0	0.006214	0	0
DNAH2	146754	broad.mit.edu	37	17	7689630	7689630	+	Silent	SNP	C	C	T	rs150195626		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:7689630C>T	uc002giu.1	+	39	6332	c.6318C>T	c.(6316-6318)CGC>CGT	p.R2106R		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2106	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCTGTGCCGCGCCGGAGACC	0.597			NA											8	18					0	0	0.006214	0	0
MYH1	4619	broad.mit.edu	37	17	10404699	10404699	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:10404699C>T	uc002gmo.2	-	27	3560	c.3466G>A	c.(3466-3468)GAA>AAA	p.E1156K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1156	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CCACCGGCTTCTTCCAGCCTC	0.622			NA											83	21					0	0	0.00361	0	0
MYH1	4619	broad.mit.edu	37	17	10406197	10406197	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:10406197T>C	uc002gmo.2	-	24	3063	c.2969A>G	c.(2968-2970)GAT>GGT	p.D990G	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	990	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AATGGTTTCATCCAGACCCGC	0.512			NA											48	107					0	0	0.00361	0	0
MYH2	4620	broad.mit.edu	37	17	10426870	10426870	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:10426870C>G	uc010coi.2	-	37	5543	c.5415G>C	c.(5413-5415)GAG>GAC	p.E1805D	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1805D|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1805	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GCTGCTCAGCCTCATCCAGAC	0.567			NA											73	28					0	0	0.00361	0	0
MYH2	4620	broad.mit.edu	37	17	10428110	10428110	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:10428110G>A	uc010coi.2	-	34	5063	c.4935C>T	c.(4933-4935)GCC>GCT	p.A1645A	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.A1645A|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1645	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGTTCCTCAGGGCCTCAGCAG	0.507			NA											31	55					0	0	0.002096	0	0
DNAH9	1770	broad.mit.edu	37	17	11772571	11772571	+	Splice_Site	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:11772571G>C	uc002gne.2	+	51	10121	c.10053_splice	c.e51+1	p.L3351_splice	DNAH9_uc010coo.2_Splice_Site_p.L2645_splice	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAACCGCCTGGTGAGTGTAAG	0.512			NA											25	19					0	0	0.004656	0	0
SGK494	124923	broad.mit.edu	37	17	26940477	26940477	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:26940477C>G	uc002hbr.1	-	2	337	c.305G>C	c.(304-306)AGG>ACG	p.R102T	SGK494_uc010waq.1_Missense_Mutation_p.R102T|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						CTGCTGCCCCCTAATGGGCCT	0.522			NA									OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	62					0	0	0.00245	0	0
NF1	4763	broad.mit.edu	37	17	29553455	29553455	+	Silent	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:29553455T>C	uc002hgg.2	+	18	2337	c.2004T>C	c.(2002-2004)GAT>GAC	p.D668D	NF1_uc002hgh.2_Silent_p.D668D|NF1_uc010csn.1_Silent_p.D528D|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	668					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ACTCTCAGGATAGTGCAGCAG	0.403			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	14					0	0	0.006214	0	0
CCL7	6354	broad.mit.edu	37	17	32597371	32597371	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:32597371G>T	uc002hhz.2	+	1	132	c.62G>T	c.(61-63)GGG>GTG	p.G21V	CCL7_uc010ctf.2_RNA	NM_006273	NP_006264	P80098	CCL7_HUMAN	chemokine (C-C motif) ligand 7 precursor	21					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			ovary(1)	1	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		AGCCCCCAGGGGCTTGCTCAG	0.557			NA											9	18					0.000442599	0.000570501	0.006214	1	0
LHX1	3975	broad.mit.edu	37	17	35300422	35300422	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:35300422G>T	uc002hnh.1	+	5	2211	c.1215G>T	c.(1213-1215)GTG>GTT	p.V405V		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	405					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				AGGCGGCCGTGTGGTAGCGGG	0.527			NA											12	5					9.31168e-06	1.26129e-05	0.001855	1	0
LASP1	3927	broad.mit.edu	37	17	37070622	37070622	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:37070622C>G	uc002hra.2	+	5	733	c.402C>G	c.(400-402)AGC>AGG	p.S134R	LASP1_uc010cvq.2_Missense_Mutation_p.A12G|LASP1_uc010wdz.1_Missense_Mutation_p.S78R	NM_006148	NP_006139	Q14847	LASP1_HUMAN	LIM and SH3 protein 1	134						cortical actin cytoskeleton	ion transmembrane transporter activity|SH3/SH2 adaptor activity|zinc ion binding			lung(1)	1						TGGGCCCTAGCGGGGGCGAGG	0.612			NA	T	MLL	AML								11	6					0	0	0.003163	0	0
STARD3	10948	broad.mit.edu	37	17	37813294	37813294	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:37813294G>A	uc002hsd.2	+	3	377	c.253G>A	c.(253-255)GAG>AAG	p.E85K	STARD3_uc010weg.1_Missense_Mutation_p.E85K|STARD3_uc010weh.1_RNA|STARD3_uc002hse.2_Missense_Mutation_p.E85K|STARD3_uc010wei.1_Missense_Mutation_p.E85K|STARD3_uc002hsf.2_5'UTR|STARD3_uc002hsg.2_5'Flank	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	85	Extracellular (Potential).|MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTTGGAGCAGGAGATCATCCA	0.557			NA											30	23					0	0	0.003755	0	0
TOP2A	7153	broad.mit.edu	37	17	38555031	38555031	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:38555031A>C	uc002huq.2	-	26	3573	c.3447T>G	c.(3445-3447)AAT>AAG	p.N1149K		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1149					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TCACTTTTTCATTTCTTAGCC	0.363			NA											16	63					0	0	0.008871	0	0
KRTAP9-2	83899	broad.mit.edu	37	17	39383101	39383101	+	Silent	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:39383101C>G	uc002hwf.2	+	1	202	c.195C>G	c.(193-195)ACC>ACG	p.T65T		NM_031961	NP_114167	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9.2	65	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].|7.					keratin filament	protein binding			upper_aerodigestive_tract(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GTAGGACCACCTGCTGCCAGC	0.652			NA											46	45					0	0	0.00361	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40838982	40838982	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:40838982G>A	uc002iay.2	+	7	1178	c.962G>A	c.(961-963)CGC>CAC	p.R321H	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	321	Laminin G-like 1.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CATAACTTCCGCGGCTGCATA	0.632			NA											26	13					0	0	0.004656	0	0
PLEKHM1	9842	broad.mit.edu	37	17	43545941	43545941	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:43545941G>C	uc002ija.2	-	5	1112	c.942C>G	c.(940-942)AGC>AGG	p.S314R	PLEKHM1_uc010wjm.1_Missense_Mutation_p.S286R|PLEKHM1_uc002ijb.2_Intron|PLEKHM1_uc010wjn.1_Missense_Mutation_p.S263R	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	314					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CCTGGGCTTTGCTGAATTCCA	0.512			NA											27	39					0	0	0.001786	0	0
KIF2B	84643	broad.mit.edu	37	17	51900476	51900476	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:51900476G>T	uc002iua.2	+	1	238	c.82G>T	c.(82-84)GAG>TAG	p.E28*		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	28					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AGACATCCAAGAGGGCATCTA	0.557			NA											28	6					4.87955e-14	8.0542e-14	0.005443	1	0
KIF2B	84643	broad.mit.edu	37	17	51900892	51900892	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:51900892G>T	uc002iua.2	+	1	654	c.498G>T	c.(496-498)CTG>CTT	p.L166L	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	166	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GCAGGCGGCTGCAGCAGGAGA	0.547			NA											46	20					7.05377e-20	1.31606e-19	0.00361	1	0
CUEDC1	404093	broad.mit.edu	37	17	55950055	55950055	+	Silent	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:55950055C>G	uc002ivd.1	-	5	1472	c.753G>C	c.(751-753)CGG>CGC	p.R251R	CUEDC1_uc002ive.1_Silent_p.R251R	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	251										skin(2)	2						AGTCGCGGTTCCGTTGCAGCT	0.622			NA											12	38					0	0	0.001368	0	0
BCAS3	54828	broad.mit.edu	37	17	58987935	58987935	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:58987935C>G	uc002iyv.3	+	12	974	c.865C>G	c.(865-867)CAG>GAG	p.Q289E	BCAS3_uc010wow.1_Missense_Mutation_p.Q76E|BCAS3_uc002iyu.3_Missense_Mutation_p.Q289E|BCAS3_uc002iyw.3_Missense_Mutation_p.Q285E|BCAS3_uc002iyx.1_Missense_Mutation_p.Q104E|BCAS3_uc002iyy.3_Missense_Mutation_p.Q60E	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	289						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AGTGGTGACTCAGCTGACAGG	0.443			NA											19	53					0	0	0.007413	0	0
BRIP1	83990	broad.mit.edu	37	17	59878764	59878764	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:59878764C>T	uc002izk.1	-	8	1131	c.990G>A	c.(988-990)GGG>GGA	p.G330G		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	330	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CTTTGCACATCCCTTGGAAAG	0.393			NA	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				72	54					0	0	0.00361	0	0
MED13	9969	broad.mit.edu	37	17	60072552	60072552	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:60072552A>C	uc002izo.2	-	10	2219	c.2142T>G	c.(2140-2142)GAT>GAG	p.D714E		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	714					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TATTTTGTCTATCTTTTTTAT	0.358			NA											13	61					0	0	0.004007	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62856235	62856235	+	Silent	SNP	C	C	T	rs143516328	by1000genomes	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:62856235C>T	uc002jey.2	-	11	4560	c.4029G>A	c.(4027-4029)CCG>CCA	p.P1343P	LRRC37A3_uc010wqg.1_Silent_p.P461P|LRRC37A3_uc002jex.1_Silent_p.P320P|LRRC37A3_uc010wqf.1_Silent_p.P381P|LRRC37A3_uc010dek.1_Silent_p.P349P	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1343	Extracellular (Potential).					integral to membrane					0						CTGCAGAGAACGGAAGCCTGT	0.463			NA											36	135					0	0	0.004289	0	0
ABCA8	10351	broad.mit.edu	37	17	66881435	66881435	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:66881435C>A	uc002jhp.2	-	25	3510	c.3331G>T	c.(3331-3333)GGA>TGA	p.G1111*	ABCA8_uc002jhq.2_Nonsense_Mutation_p.G1151*|ABCA8_uc010wqq.1_Nonsense_Mutation_p.G1151*	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1111	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					AACGCAAATCCAGCCACAGAG	0.358			NA											20	41					0.000132079	0.000173038	0.008871	1	0
MGAT5B	146664	broad.mit.edu	37	17	74901391	74901391	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:74901391G>T	uc002jti.2	+	6	967	c.864G>T	c.(862-864)GGG>GGT	p.G288G	MGAT5B_uc002jth.2_Silent_p.G277G	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	277	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						AGAAGCTGGGGGCCACCCAGA	0.647			NA											20	7					3.5997e-14	5.99325e-14	0.002299	1	0
SEC14L1	6397	broad.mit.edu	37	17	75205438	75205438	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:75205438G>A	uc002jto.2	+	14	1758	c.1491G>A	c.(1489-1491)GAG>GAA	p.E497E	SEC14L1_uc010dhc.2_Silent_p.E497E|SEC14L1_uc010wth.1_Silent_p.E497E|SEC14L1_uc002jtm.2_Silent_p.E497E|SEC14L1_uc010wti.1_Silent_p.E463E|SEC14L1_uc010wtj.1_Silent_p.E57E|SEC14L1_uc002jtr.2_5'UTR	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	497					transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						AAGTGCCAGAGGGTGGACTGG	0.552			NA											3	30					0	0	0.004672	0	0
LAMA1	284217	broad.mit.edu	37	18	7044817	7044817	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:7044817G>A	uc002knm.2	-	7	974	c.880C>T	c.(880-882)CAT>TAT	p.H294Y	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	294	Laminin EGF-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAGTATTATGCTCACATTGA	0.448			NA											67	59					0	0	0.00361	0	0
FAM38B	63895	broad.mit.edu	37	18	10672706	10672706	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:10672706C>A	uc002kor.3	-	13	1998	c.1858G>T	c.(1858-1860)GGG>TGG	p.G620W	FAM38B_uc002koq.2_Missense_Mutation_p.G455W	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2663	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						GCCAGGAACCCCAGACTTGGG	0.463			NA											34	118					2.42023e-17	4.33832e-17	0.003271	1	0
ESCO1	114799	broad.mit.edu	37	18	19154125	19154125	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:19154125C>A	uc002kth.1	-	4	1614	c.680G>T	c.(679-681)TGT>TTT	p.C227F	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	227					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						CTTCTGAGGACACTTTTCAGA	0.403			NA											41	70					3.61848e-18	6.5971e-18	0.007835	1	0
NPC1	4864	broad.mit.edu	37	18	21136522	21136523	+	Missense_Mutation	DNP	CC	CC	AA	rs147795644	byFrequency	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:21136522_21136523CC>AA	uc002kum.3	-	8	1284_1285	c.1010_1011GG>TT	c.(1009-1011)CGG>CTT	p.R337L	NPC1_uc010xaz.1_Missense_Mutation_p.R138L|NPC1_uc010xba.1_Missense_Mutation_p.R182L	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	337					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GTGTGAACAGCCGCCTCAAGCA	0.574			NA											14	15					0	0	0.004672	0	0
ZNF521	25925	broad.mit.edu	37	18	22804644	22804644	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:22804644G>T	uc002kvk.2	-	4	3485	c.3238C>A	c.(3238-3240)CTG>ATG	p.L1080M	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.L1080M|ZNF521_uc002kvl.2_Missense_Mutation_p.L860M	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1080	C2H2-type 25; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGTTTCACCAGATCTTGCTTG	0.542			NA	T	PAX5	ALL								18	39					9.16793e-09	1.35262e-08	0.00499	1	0
CDH2	1000	broad.mit.edu	37	18	25565085	25565085	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:25565085C>A	uc002kwg.2	-	13	2547	c.2088G>T	c.(2086-2088)CTG>CTT	p.L696L	CDH2_uc010xbn.1_Silent_p.L665L	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	696	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CCTTCACACGCAGGATGGAAA	0.468			NA											17	27					8.34094e-07	1.16944e-06	0.008871	1	0
ASXL3	80816	broad.mit.edu	37	18	31323231	31323231	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:31323231C>A	uc010dmg.1	+	12	3474	c.3419C>A	c.(3418-3420)CCA>CAA	p.P1140Q	ASXL3_uc002kxq.2_Missense_Mutation_p.P847Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GAAGGGCCTCCAAACTTAGAA	0.483			NA											6	10					0.00198382	0.00250656	0.001984	1	0
ST8SIA5	29906	broad.mit.edu	37	18	44260249	44260249	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:44260249G>T	uc002lcj.1	-	7	1455	c.887C>A	c.(886-888)GCC>GAC	p.A296D	ST8SIA5_uc002lci.1_Missense_Mutation_p.A143D|ST8SIA5_uc010xcy.1_Missense_Mutation_p.A332D|ST8SIA5_uc010xcz.1_Missense_Mutation_p.A265D	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	296	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GATGCGCTTGGCGCGCACCCC	0.622			NA											5	20					2.0095e-06	2.76883e-06	0.001984	1	0
ME2	4200	broad.mit.edu	37	18	48458657	48458657	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:48458657A>G	uc002ley.2	+	13	1600	c.1344A>G	c.(1342-1344)CCA>CCG	p.P448P	ME2_uc010dpd.2_Silent_p.P448P	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	448					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	GTGGCAGTCCATTTGGGCCAG	0.358			NA											25	42					0	0	0.007291	0	0
DCC	1630	broad.mit.edu	37	18	50985817	50985817	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:50985817C>A	uc002lfe.1	+	24	4195	c.3608C>A	c.(3607-3609)ACC>AAC	p.T1203N	DCC_uc010dpf.1_Missense_Mutation_p.T838N	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1203	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGCAAAAGCACCTCTCATTCA	0.478			NA											22	27					2.37509e-13	3.88688e-13	0.001523	1	0
ZCCHC2	54877	broad.mit.edu	37	18	60237354	60237354	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:60237354G>C	uc002lip.3	+	12	1865	c.1865G>C	c.(1864-1866)GGC>GCC	p.G622A	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Missense_Mutation_p.G92A	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	622					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TTGGACATTGGCTCTGGACAT	0.313			NA											5	7					0	0	0.001168	0	0
CDH7	1005	broad.mit.edu	37	18	63547670	63547670	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:63547670G>T	uc002ljz.2	+	12	2223	c.1898G>T	c.(1897-1899)CGG>CTG	p.R633L	CDH7_uc002lkb.2_Missense_Mutation_p.R633L	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	633	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ATGAGAAGACGGAAAAAAGAG	0.438			NA											9	28					3.09899e-07	4.42251e-07	0.004482	1	0
TSHZ1	10194	broad.mit.edu	37	18	72999633	72999633	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr18:72999633G>T	uc002lly.2	+	2	2699	c.2136G>T	c.(2134-2136)CTG>CTT	p.L712L		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	757						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		ACACCCACCTGGGCAAGGTGT	0.602			NA											7	31					8.12818e-05	0.00010678	0.001984	1	0
ZBTB7A	51341	broad.mit.edu	37	19	4047778	4047778	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:4047778T>A	uc002lzh.2	-	3	1802	c.1727A>T	c.(1726-1728)GAC>GTC	p.D576V	ZBTB7A_uc002lzi.2_Missense_Mutation_p.D576V	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	576					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGTTACCGTCGGTGGCGGC	0.542			NA											11	22					0	0	0.000978	0	0
ANKRD24	170961	broad.mit.edu	37	19	4224484	4224484	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:4224484C>A	uc010dtt.1	+	22	3699	c.3423C>A	c.(3421-3423)CTC>CTA	p.L1141L		NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1141											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TGCAGAGACTCCAGGCTCAGG	0.612			NA											16	24					6.94344e-10	1.06882e-09	0.006122	1	0
SAFB2	9667	broad.mit.edu	37	19	5610692	5610692	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:5610692T>G	uc002mcd.2	-	8	1365	c.1153A>C	c.(1153-1155)AAG>CAG	p.K385Q		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TTTTCTTCCTTAAAAGAGCTA	0.323	Ovarian(127;888 1728 23957 44128 52668)		NA											10	9					0	0	0.006214	0	0
MUC16	94025	broad.mit.edu	37	19	8968943	8968943	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:8968943T>A	uc002mkp.2	-	80	43277	c.43073A>T	c.(43072-43074)AAC>ATC	p.N14358I	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.N1158I|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGAGTTGGTTGAGCTGAAA	0.438			NA											6	11					0	0	0.001168	0	0
OR7G1	125962	broad.mit.edu	37	19	9226437	9226437	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:9226437C>T	uc002mks.1	-	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TTCTGGGTCCCATGTTTTTGA	0.418			NA											40	18					0	0	0.004878	0	0
CDC37	11140	broad.mit.edu	37	19	10504034	10504034	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:10504034G>A	uc002mof.1	-	6	926	c.810C>T	c.(808-810)CGC>CGT	p.R270R	CDC37_uc002moe.1_Silent_p.R225R|CDC37_uc010dxf.1_Silent_p.R107R|CDC37_uc002mog.1_Intron|CDC37_uc002moh.2_Silent_p.R270R	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	270					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		CCTTCTCGATGCGCAGCTTGG	0.657			NA											55	5					0	0	0.00361	0	0
SLC1A6	6511	broad.mit.edu	37	19	15073090	15073090	+	Missense_Mutation	SNP	G	G	A	rs141656938	byFrequency	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:15073090G>A	uc002naa.1	-	5	667	c.659C>T	c.(658-660)CCG>CTG	p.P220L	SLC1A6_uc010dzu.1_Missense_Mutation_p.P220L|SLC1A6_uc010xod.1_Missense_Mutation_p.P156L|SLC1A6_uc002nab.2_Missense_Mutation_p.P220L|SLC1A6_uc002nac.2_Missense_Mutation_p.P220L	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	220	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	GGAGGCACCCGGCTCAGACCC	0.542			NA											67	22					0	0	0.00361	0	0
CYP4F12	66002	broad.mit.edu	37	19	15794413	15794413	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:15794413G>C	uc002nbl.2	+	7	819	c.758G>C	c.(757-759)GGG>GCG	p.G253A		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TCCCATGACGGGCGGCGCTTC	0.552			NA											50	25					0	0	0.00361	0	0
OR10H1	26539	broad.mit.edu	37	19	15918728	15918728	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:15918728C>A	uc002nbq.2	-	1	209	c.120G>T	c.(118-120)CTG>CTT	p.L40L		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCAGGTTGCCCAGCAGCGTGA	0.597			NA											54	11					2.03366e-24	3.96398e-24	0.00361	1	0
CIB3	117286	broad.mit.edu	37	19	16280476	16280476	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:16280476G>T	uc002nds.2	-	3	163	c.163C>A	c.(163-165)CCC>ACC	p.P55T	CIB3_uc010eae.2_5'UTR|CIB3_uc010eaf.2_Intron|CIB3_uc010eag.2_Intron	NM_054113	NP_473454	Q96Q77	CIB3_HUMAN	DNA-dependent protein kinase catalytic	55							calcium ion binding			ovary(1)	1						AGCTCGTAGGGCACCTTCACA	0.517			NA											10	4					5.50884e-06	7.50423e-06	0.001368	1	0
MAP1S	55201	broad.mit.edu	37	19	17837847	17837847	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:17837847A>T	uc002nhe.1	+	5	1663	c.1654A>T	c.(1654-1656)AAG>TAG	p.K552*	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Nonsense_Mutation_p.K552*|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Nonsense_Mutation_p.K526*	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	552	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GCCCAACCTCAAGAAGACGAA	0.682			NA											11	2					0	0	0.001368	0	0
ZNF536	9745	broad.mit.edu	37	19	31040383	31040383	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:31040383C>G	uc002nsu.1	+	4	3995	c.3857C>G	c.(3856-3858)ACA>AGA	p.T1286R	ZNF536_uc010edd.1_Missense_Mutation_p.T1286R	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCAAGTAGCACAGCAAATTCT	0.488			NA											17	53					0	0	0.00499	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768676	31768676	+	Missense_Mutation	SNP	G	G	A	rs143305127		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:31768676G>A	uc002nsy.3	-	2	2088	c.2023C>T	c.(2023-2025)CGG>TGG	p.R675W		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	675					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CACCCATCCCGCGGGGGGCTG	0.652			NA											8	29					0	0	0.00308	0	0
GPATCH1	55094	broad.mit.edu	37	19	33588736	33588736	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:33588736G>A	uc002nug.1	+	8	1242	c.928G>A	c.(928-930)GTT>ATT	p.V310I		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	310						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					GTATGACACTGTTCTGAAGGA	0.453	Pancreas(67;88 1713 4567 18227)		NA											57	142					0	0	0.00361	0	0
CD22	933	broad.mit.edu	37	19	35831821	35831821	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:35831821C>T	uc010edt.2	+	7	1364	c.1287C>T	c.(1285-1287)CCC>CCT	p.P429P	CD22_uc010xst.1_Silent_p.P257P|CD22_uc010edu.2_Silent_p.P341P|CD22_uc010edv.2_Silent_p.P429P|CD22_uc002nzb.3_Silent_p.P252P|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	429	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TTCAAAACCCCATGCCGATTC	0.512	Ovarian(42;1009 1133 23674 26041)		NA											9	23					0	0	0.008291	0	0
MLL4	9757	broad.mit.edu	37	19	36216509	36216509	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:36216509A>G	uc010eei.2	+	13	3772	c.3772A>G	c.(3772-3774)AAA>GAA	p.K1258E		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1258	PHD-type 2.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGTGGACGCAAAGGTCGTGG	0.637			NA											22	46					0	0	0.001523	0	0
NPHS1	4868	broad.mit.edu	37	19	36334447	36334447	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:36334447C>A	uc002oby.2	-	17	2261	c.2261G>T	c.(2260-2262)GGG>GTG	p.G754V		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	754	Ig-like C2-type 7.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CACAGAACCCCCGACGTTCAC	0.592			NA											26	37					4.02929e-09	6.07561e-09	0.002096	1	0
ZFP30	22835	broad.mit.edu	37	19	38127134	38127134	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:38127134C>A	uc002ogv.1	-	6	824	c.308G>T	c.(307-309)TGG>TTG	p.W103L	ZFP30_uc002ogw.1_Missense_Mutation_p.W103L|ZFP30_uc002ogx.1_Missense_Mutation_p.W103L|ZFP30_uc010xtt.1_Missense_Mutation_p.W102L	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CATTACCTTCCACTGAGATAA	0.338			NA											19	20					1.33834e-09	2.0308e-09	0.007413	1	0
RYR1	6261	broad.mit.edu	37	19	38990296	38990296	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:38990296C>G	uc002oit.2	+	44	7179	c.7049C>G	c.(7048-7050)GCC>GGC	p.A2350G	RYR1_uc002oiu.2_Missense_Mutation_p.A2350G|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2350	Cytoplasmic.|6 X approximate repeats.		A -> T (in MHS1; reveals an altered calcium dependence and increased caffeine sensitivity).		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAGGAGAACGCCAATGTGGTG	0.667			NA											3	17					0	0	0.004672	0	0
RYR1	6261	broad.mit.edu	37	19	39062816	39062816	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:39062816A>T	uc002oit.2	+	95	14034	c.13904A>T	c.(13903-13905)GAA>GTA	p.E4635V	RYR1_uc002oiu.2_Missense_Mutation_p.E4630V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4635					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTCCTGGAGGAAAGCACAGGC	0.587			NA											25	48					0	0	0.005443	0	0
LRFN1	57622	broad.mit.edu	37	19	39805183	39805183	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:39805183C>A	uc002okw.2	-	1	794	c.794G>T	c.(793-795)CGG>CTG	p.R265L		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	265	LRRCT.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GCGGGTCAGCCGCCGCAGCCA	0.692			NA											6	1					1.06961e-07	1.54482e-07	0.00308	1	0
ADCK4	79934	broad.mit.edu	37	19	41220260	41220260	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:41220260C>A	uc002oor.2	-	3	447	c.145G>T	c.(145-147)GGG>TGG	p.G49W	ADCK4_uc002ooq.1_Missense_Mutation_p.G49W|ADCK4_uc002oos.2_Missense_Mutation_p.G49W|ITPKC_uc002oot.2_5'Flank	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	49						integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			CTCCCAGGCCCATCCTGGTAA	0.602			NA											19	31					1.33834e-09	2.0308e-09	0.007413	1	0
CEACAM5	1048	broad.mit.edu	37	19	42219636	42219636	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:42219636C>A	uc002ork.2	+	4	892	c.771C>A	c.(769-771)CTC>CTA	p.L257L	CEACAM5_uc010ehz.1_3'UTR|CEACAM5_uc002orj.1_Silent_p.L257L|CEACAM5_uc002orl.2_Silent_p.L257L	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	257	Ig-like 3.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		ATCTGAACCTCTCCTGCCACG	0.498			NA											19	23					5.3912e-06	7.36491e-06	0.006122	1	0
ARHGEF1	9138	broad.mit.edu	37	19	42410694	42410694	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:42410694C>A	uc002orx.2	+	27	2686	c.2577C>A	c.(2575-2577)GGC>GGA	p.G859G	ARHGEF1_uc002ory.2_Silent_p.G826G|ARHGEF1_uc002orz.2_Silent_p.G697G|ARHGEF1_uc002osa.2_Silent_p.G874G|ARHGEF1_uc002osb.2_Intron|ARHGEF1_uc002osc.2_Intron|ARHGEF1_uc002osd.2_Silent_p.G518G|ARHGEF1_uc002ose.2_Silent_p.G303G	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	859					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		TCCCAGGGGGCGGCCCCCTGA	0.677			NA											7	18					8.12818e-05	0.00010678	0.001984	1	0
ZNF225	7768	broad.mit.edu	37	19	44635327	44635327	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:44635327A>T	uc002oyj.1	+	5	803	c.560A>T	c.(559-561)TAT>TTT	p.Y187F	ZNF225_uc010eje.1_Missense_Mutation_p.Y104F|ZNF225_uc010ejf.1_Missense_Mutation_p.Y187F	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	187	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGTTTCTGTTATAGCTCAGCT	0.398			NA											20	33					0	0	0.007413	0	0
SYMPK	8189	broad.mit.edu	37	19	46357498	46357498	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:46357498C>A	uc002pdn.2	-	3	351	c.106G>T	c.(106-108)GTG>TTG	p.V36L	SYMPK_uc002pdo.1_Missense_Mutation_p.V36L|SYMPK_uc002pdp.1_Missense_Mutation_p.V36L|SYMPK_uc002pdq.1_Missense_Mutation_p.V36L	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	36	Interaction with HSF1.				cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		AGATCCACCACCTGGAAGGAG	0.632			NA											10	23					6.40141e-05	8.45586e-05	0.000978	1	0
DHX34	9704	broad.mit.edu	37	19	47876150	47876150	+	Silent	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:47876150G>C	uc010xyn.1	+	8	2273	c.1932G>C	c.(1930-1932)ACG>ACC	p.T644T	DHX34_uc010elc.1_Silent_p.T559T	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	644						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		ACCCCTTCACGCTCTTCAACG	0.677			NA											11	16					0	0	0.00245	0	0
RASIP1	54922	broad.mit.edu	37	19	49238578	49238578	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:49238578C>A	uc002pki.2	-	4	1251	c.1054G>T	c.(1054-1056)GGG>TGG	p.G352W		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	352					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		TCGGCTGCCCCTGGGGCCATG	0.647			NA											13	12					5.50884e-06	7.50423e-06	0.001368	1	0
SLC17A7	57030	broad.mit.edu	37	19	49933857	49933857	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:49933857G>T	uc002pnp.2	-	12	1774	c.1602C>A	c.(1600-1602)CCC>CCA	p.P534P	SLC17A7_uc002pno.2_Silent_p.P196P	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	534	Cytoplasmic (Potential).|Pro-rich.				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GGGGTGCAGGGGGTGCCCCCG	0.652			NA											10	20					1.08611e-07	1.56628e-07	0.000978	1	0
ZNF677	342926	broad.mit.edu	37	19	53741621	53741621	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:53741621A>T	uc002qbf.1	-	5	544	c.359T>A	c.(358-360)ATG>AAG	p.M120K	ZNF677_uc002qbg.1_Missense_Mutation_p.M120K	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		GGTCAAAGGCATTCCTTTGTA	0.353			NA											24	49					0	0	0.00278	0	0
LILRA6	79168	broad.mit.edu	37	19	54744954	54744954	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:54744954G>T	uc002qeu.1	-	5	832	c.708C>A	c.(706-708)GCC>GCA	p.A236A	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Silent_p.A236A|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Silent_p.A236A|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.A236A|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Silent_p.A236A|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Silent_p.A236A|LILRA6_uc010yeq.1_Silent_p.A236A|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Silent_p.A97A	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	236	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTGCCCAGGGGCCAGGACAG	0.642			NA											7	33					5.4927e-09	8.20483e-09	0.004482	1	0
LILRA2	11027	broad.mit.edu	37	19	55086271	55086271	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:55086271G>A	uc002qgg.3	+	4	515	c.426G>A	c.(424-426)CAG>CAA	p.Q142Q	LILRA2_uc010ern.2_Silent_p.Q142Q|LILRA2_uc002qgf.2_Silent_p.Q142Q|LILRA2_uc010yfe.1_Silent_p.Q142Q|LILRA2_uc010yff.1_Silent_p.Q130Q|LILRA2_uc010ero.2_Silent_p.Q130Q|LILRA2_uc010yfg.1_Silent_p.Q142Q	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	142	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TGACCCTCCAGTGTGTCTCAC	0.557			NA											42	56					0	0	0.00874	0	0
LILRA1	11024	broad.mit.edu	37	19	55107261	55107261	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:55107261C>A	uc002qgh.1	+	6	1001	c.819C>A	c.(817-819)CCC>CCA	p.P273P	LILRA2_uc010yfg.1_Silent_p.P271P|LILRA1_uc010yfh.1_Silent_p.P273P	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	273	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GCCCACAGCCCCAGGCTGGGC	0.597			NA											23	47					7.87624e-14	1.29559e-13	0.00278	1	0
NLRP2	55655	broad.mit.edu	37	19	55501966	55501966	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:55501966C>G	uc002qij.2	+	10	2720	c.2634C>G	c.(2632-2634)AAC>AAG	p.N878K	NLRP2_uc010yfp.1_Missense_Mutation_p.N855K|NLRP2_uc010esn.2_Missense_Mutation_p.N854K|NLRP2_uc010eso.2_Missense_Mutation_p.N875K|NLRP2_uc010esp.2_Missense_Mutation_p.N856K	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	878	LRR 3.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TGGCCAAGAACCCCATTGGGA	0.537			NA											27	27					0	0	0.007291	0	0
NLRP13	126204	broad.mit.edu	37	19	56424536	56424536	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:56424536T>A	uc010ygg.1	-	5	672	c.647A>T	c.(646-648)CAG>CTG	p.Q216L		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	216							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAGTAGGCGCTGCAGTTCCTC	0.512			NA											37	60					0	0	0.003755	0	0
NLRP8	126205	broad.mit.edu	37	19	56466135	56466135	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:56466135C>A	uc002qmh.2	+	3	782	c.711C>A	c.(709-711)CGC>CGA	p.R237R	NLRP8_uc010etg.2_Silent_p.R237R	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	237	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CCCACAAGCGCTGGTGTGCTT	0.532			NA											32	42					1.61788e-16	2.84166e-16	0.002445	1	0
NLRP8	126205	broad.mit.edu	37	19	56467457	56467457	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:56467457C>A	uc002qmh.2	+	3	2104	c.2033C>A	c.(2032-2034)CCT>CAT	p.P678H	NLRP8_uc010etg.2_Missense_Mutation_p.P678H	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	678						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AGCTCCCATCCTGGCTCTGAG	0.552			NA											16	27					3.45872e-05	4.60682e-05	0.004007	1	0
ZNF470	388566	broad.mit.edu	37	19	57085817	57085817	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:57085817T>C	uc002qnl.3	+	4	791	c.115T>C	c.(115-117)TGG>CGG	p.W39R	ZNF470_uc010etn.2_RNA	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TGAATGGGAGTGGCTGAATCT	0.428			NA											45	53					0	0	0.002522	0	0
PEG3	5178	broad.mit.edu	37	19	57328466	57328466	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:57328466C>A	uc002qnu.2	-	7	1695	c.1344G>T	c.(1342-1344)GGG>GGT	p.G448G	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.G419G|PEG3_uc002qnv.2_Silent_p.G448G|PEG3_uc002qnw.2_Silent_p.G324G|PEG3_uc002qnx.2_Silent_p.G322G|PEG3_uc010etr.2_Silent_p.G448G	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	448					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATGGCATTGCCCCAAAATCAA	0.483			NA											32	65					1.61788e-16	2.84166e-16	0.002445	1	0
ZNF543	125919	broad.mit.edu	37	19	57839116	57839116	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:57839116C>G	uc002qoi.1	+	4	631	c.286C>G	c.(286-288)CTG>GTG	p.L96V		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTTTTCTCACCTGGCCTTGCC	0.458			NA											16	55					0	0	0.003163	0	0
ZNF132	7691	broad.mit.edu	37	19	58945522	58945522	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:58945522G>T	uc002qst.3	-	3	1690	c.1289C>A	c.(1288-1290)CCG>CAG	p.P430Q		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	430						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		GCATTCATACGGTCTTTCTCC	0.468			NA											52	40					5.13769e-22	9.79531e-22	0.00361	1	0
FAM110C	642273	broad.mit.edu	37	2	45522	45522	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:45522C>T	uc010yim.1	-	1	864	c.864G>A	c.(862-864)GAG>GAA	p.E288E		NM_001077710	NP_001071178	Q1W6H9	F110C_HUMAN	hypothetical protein LOC642273	288						microtubule|microtubule organizing center|spindle pole					0	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		GGGCGTTCCTCTCGATGACCG	0.657			NA											9	52					0	0	0.008291	0	0
ATAD2B	54454	broad.mit.edu	37	2	24005766	24005766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:24005766C>A	uc002rek.3	-	22	3400	c.3106G>T	c.(3106-3108)GAG>TAG	p.E1036*	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Nonsense_Mutation_p.E276*|ATAD2B_uc002rej.3_Nonsense_Mutation_p.E204*	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1036	Bromo.						ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATTATACTCTAAAGCATTG	0.358			NA											34	23					2.6416e-12	4.22216e-12	0.00623	1	0
CGREF1	10669	broad.mit.edu	37	2	27327173	27327173	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:27327173G>A	uc010eys.1	-	2	204	c.62C>T	c.(61-63)CCA>CTA	p.P21L	CGREF1_uc010ylf.1_Intron|CGREF1_uc002rip.1_5'UTR|CGREF1_uc002riq.2_Missense_Mutation_p.P21L|CGREF1_uc010eyr.1_Missense_Mutation_p.P143L|CGREF1_uc002rir.1_Missense_Mutation_p.P21L|CGREF1_uc002ris.2_Missense_Mutation_p.P21L	NM_006569	NP_006560	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	21					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCATCCTTTGGGGCAGCCTG	0.562			NA											19	29					0	0	0.001882	0	0
IFT172	26160	broad.mit.edu	37	2	27676886	27676886	+	Missense_Mutation	SNP	C	C	T	rs141440865		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:27676886C>T	uc002rku.2	-	33	3725	c.3674G>A	c.(3673-3675)CGG>CAG	p.R1225Q	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1225					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TCTCTGGGCCCGGAGCAGCAG	0.622			NA											50	81					0	0	0.00361	0	0
SRBD1	55133	broad.mit.edu	37	2	45778281	45778282	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:45778281_45778282GC>AT	uc002rus.2	-	12	1733_1734	c.1657_1658GC>AT	c.(1657-1659)GCT>ATT	p.A553I	SRBD1_uc010yoc.1_Missense_Mutation_p.A72I	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	553					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGAAATTATAGCTAATTTGCAA	0.391			NA											22	30					0	0	0.004672	0	0
PSME4	23198	broad.mit.edu	37	2	54146345	54146345	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:54146345C>A	uc002rxp.2	-	20	2515	c.2459G>T	c.(2458-2460)TGT>TTT	p.C820F	PSME4_uc010yop.1_Missense_Mutation_p.C706F|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.C195F|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	820					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GCCAATTAAACAGTTGTGCAC	0.333			NA											20	40					5.35356e-11	8.37531e-11	0.00278	1	0
VRK2	7444	broad.mit.edu	37	2	58311222	58311222	+	Splice_Site	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:58311222A>T	uc002rzo.2	+	6	882	c.137_splice	c.e6-2	p.A46_splice	VRK2_uc010fcb.2_Splice_Site_p.A46_splice|VRK2_uc002rzs.2_Splice_Site_p.A46_splice|VRK2_uc002rzr.2_Splice_Site_p.A46_splice|VRK2_uc010fcc.2_Splice_Site|VRK2_uc002rzv.2_Splice_Site_p.A46_splice|VRK2_uc010fcd.2_Splice_Site_p.A23_splice|VRK2_uc002rzp.2_Splice_Site_p.A46_splice|VRK2_uc010ypg.1_Splice_Site_p.A46_splice|VRK2_uc002rzq.2_Splice_Site_p.A46_splice|VRK2_uc002rzu.2_Splice_Site_p.A46_splice|VRK2_uc002rzt.2_Splice_Site|VRK2_uc010yph.1_5'Flank	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2							integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TTTTGTCTGCAGCTTTCCCCA	0.229			NA											36	55					0	0	0.004878	0	0
USP34	9736	broad.mit.edu	37	2	61571046	61571046	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:61571046C>A	uc002sbe.2	-	16	2426	c.2404G>T	c.(2404-2406)GAG>TAG	p.E802*		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	802					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TGAACTAGCTCCTCTTCACAT	0.398			NA											20	73					1.33834e-09	2.0308e-09	0.007413	1	0
DYSF	8291	broad.mit.edu	37	2	71892314	71892314	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:71892314G>C	uc002sie.2	+	46	5456	c.5080G>C	c.(5080-5082)GAC>CAC	p.D1694H	DYSF_uc010feg.2_Missense_Mutation_p.D1725H|DYSF_uc010feh.2_Missense_Mutation_p.D1701H|DYSF_uc002sig.3_Missense_Mutation_p.D1680H|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.D1715H|DYSF_uc010fef.2_Missense_Mutation_p.D1732H|DYSF_uc010fei.2_Missense_Mutation_p.D1711H|DYSF_uc010fek.2_Missense_Mutation_p.D1712H|DYSF_uc010fej.2_Missense_Mutation_p.D1702H|DYSF_uc010fel.2_Missense_Mutation_p.D1681H|DYSF_uc010feo.2_Missense_Mutation_p.D1726H|DYSF_uc010fem.2_Missense_Mutation_p.D1716H|DYSF_uc010fen.2_Missense_Mutation_p.D1733H|DYSF_uc002sif.2_Missense_Mutation_p.D1695H|DYSF_uc010yqy.1_Missense_Mutation_p.D575H|DYSF_uc010yqz.1_Missense_Mutation_p.D455H	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1694	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCAGTGGCGGGACCAGCTCCG	0.562			NA											28	69					0	0	0.002836	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315800	73315800	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:73315800C>A	uc002siu.3	-	3	1187	c.946G>T	c.(946-948)GCT>TCT	p.A316S	RAB11FIP5_uc002sit.3_Missense_Mutation_p.A238S	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	316					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CGAGGAGGAGCCACTCGCATC	0.592			NA											9	8					1.12685e-05	1.52204e-05	0.004482	1	0
MRPL19	9801	broad.mit.edu	37	2	75881930	75881930	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:75881930C>T	uc002snl.2	+	5	569	c.544C>T	c.(544-546)CGG>TGG	p.R182W	MRPL19_uc002snm.1_Missense_Mutation_p.R182W	NM_014763	NP_055578	P49406	RM19_HUMAN	mitochondrial ribosomal protein L19 precursor	182					translation	mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome				0						ATTAGAGAAACGGCTGGATGA	0.388			NA											17	66					0	0	0.007413	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745606	77745606	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:77745606C>A	uc002snr.2	-	3	1804	c.1389G>T	c.(1387-1389)ATG>ATT	p.M463I	LRRTM4_uc002snq.2_Missense_Mutation_p.M463I|LRRTM4_uc002sns.2_Missense_Mutation_p.M463I|LRRTM4_uc002snt.2_Missense_Mutation_p.M464I	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	463	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GCCGCCTCTTCATAAGAGAGT	0.473			NA											19	19					7.07596e-05	9.33404e-05	0.006122	1	0
REG3A	5068	broad.mit.edu	37	2	79385835	79385835	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:79385835G>T	uc002sod.1	-	2	392	c.137C>A	c.(136-138)GCC>GAC	p.A46D	REG3A_uc002soe.1_Missense_Mutation_p.A46D|REG3A_uc002sof.1_Missense_Mutation_p.A46D	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	46	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GGAGCCATAGGCCTTGGAGCC	0.547			NA											22	22					3.5997e-14	5.99325e-14	0.002299	1	0
SLC9A4	389015	broad.mit.edu	37	2	103148809	103148809	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:103148809G>T	uc002tbz.3	+	12	2516	c.2059G>T	c.(2059-2061)GGA>TGA	p.G687*		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	687	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CAGTGATCCAGGATCCCCATC	0.453			NA											22	90					2.70639e-06	3.72372e-06	0.002299	1	0
SLC5A7	60482	broad.mit.edu	37	2	108618393	108618393	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:108618393C>T	uc002tdv.2	+	6	914	c.638C>T	c.(637-639)GCA>GTA	p.A213V	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.A213V|SLC5A7_uc010ywn.1_Missense_Mutation_p.A100V	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	213	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CCTGCAGTCGCAGACATCGGG	0.488			NA											21	69					0	0	0.00333	0	0
POTEF	728378	broad.mit.edu	37	2	130832405	130832405	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:130832405C>A	uc010fmh.2	-	17	3040	c.2640G>T	c.(2638-2640)CTG>CTT	p.L880L		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	880	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						CCCGCCCAGCCAGGTCTAGGC	0.592			NA											18	25					3.52763e-06	4.83286e-06	0.00499	1	0
THSD7B	80731	broad.mit.edu	37	2	137988717	137988717	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:137988717G>C	uc002tva.1	+	7	1734	c.1734G>C	c.(1732-1734)GAG>GAC	p.E578D	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.E468D	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGTGGACGGAGTGGTCATCCT	0.512			NA											10	17					0	0	0.008291	0	0
LRP1B	53353	broad.mit.edu	37	2	141643783	141643783	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:141643783G>A	uc002tvj.1	-	24	4860	c.3888C>T	c.(3886-3888)CAC>CAT	p.H1296H	LRP1B_uc010fnl.1_Silent_p.H478H	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1296	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTGATTGAAGTGAAAATCAA	0.333	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			11	28					0	0	0.00245	0	0
TTN	7273	broad.mit.edu	37	2	179397732	179397732	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179397732C>T	uc010zfg.1	-	307	96130	c.95906G>A	c.(95905-95907)CGG>CAG	p.R31969Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R25664Q|TTN_uc010zfi.1_Missense_Mutation_p.R25597Q|TTN_uc010zfj.1_Missense_Mutation_p.R25472Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32896							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAAGGCATCCGGAGTTTTCT	0.458			NA											53	154					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179463659	179463660	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179463659_179463660GG>TC	uc010zfg.1	-	240	49297_49298	c.49073_49074CC>GA	c.(49072-49074)ACC>AGA	p.T16358R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T10053R|TTN_uc010zfi.1_Missense_Mutation_p.T9986R|TTN_uc010zfj.1_Missense_Mutation_p.T9861R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17285							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTGAAGTGGTGTCTTTCAT	0.455			NA											10	37					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179579280	179579280	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179579280T>G	uc010zfg.1	-	88	22713	c.22489A>C	c.(22489-22491)AAG>CAG	p.K7497Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K4158Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8424							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACTGAGCTTCTTCACAAAT	0.438			NA											20	17					0	0	0.002299	0	0
TTN	7273	broad.mit.edu	37	2	179590619	179590619	+	Silent	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179590619T>A	uc010zfg.1	-	67	16922	c.16698A>T	c.(16696-16698)GCA>GCT	p.A5566A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.A2227A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6493							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTTTTGGATGCAATCTTGT	0.428			NA											24	15					0	0	0.002299	0	0
TTN	7273	broad.mit.edu	37	2	179592015	179592015	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179592015C>A	uc010zfg.1	-	66	16569	c.16345G>T	c.(16345-16347)GGA>TGA	p.G5449*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.G2110*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6376							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGGGGATCCAGCTATCTTG	0.418			NA											33	13					1.04352e-10	1.62456e-10	0.003755	1	0
TTN	7273	broad.mit.edu	37	2	179642533	179642533	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179642533C>G	uc010zfg.1	-	25	4602	c.4378G>C	c.(4378-4380)GTG>CTG	p.V1460L	TTN_uc010zfh.1_Missense_Mutation_p.V1414L|TTN_uc010zfi.1_Missense_Mutation_p.V1414L|TTN_uc010zfj.1_Missense_Mutation_p.V1414L|TTN_uc002unb.2_Missense_Mutation_p.V1460L|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1460							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTTTAACACAAAGACTGGT	0.448			NA											22	71					0	0	0.001523	0	0
TTN	7273	broad.mit.edu	37	2	179648463	179648463	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179648463G>A	uc010zfg.1	-	17	3049	c.2825C>T	c.(2824-2826)CCA>CTA	p.P942L	TTN_uc010zfh.1_Missense_Mutation_p.P896L|TTN_uc010zfi.1_Missense_Mutation_p.P896L|TTN_uc010zfj.1_Missense_Mutation_p.P896L|TTN_uc002unb.2_Missense_Mutation_p.P942L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	942							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAGTTGGTGGAGTAACAGG	0.353			NA											23	72					0	0	0.00632	0	0
TTN	7273	broad.mit.edu	37	2	179650358	179650358	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179650358G>T	uc010zfg.1	-	15	2706	c.2482C>A	c.(2482-2484)CAT>AAT	p.H828N	TTN_uc010zfh.1_Missense_Mutation_p.H782N|TTN_uc010zfi.1_Missense_Mutation_p.H782N|TTN_uc010zfj.1_Missense_Mutation_p.H782N|TTN_uc002unb.2_Missense_Mutation_p.H828N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	828							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATATCCATGTTCTGTCTTA	0.408			NA											16	55					1.45105e-14	2.44562e-14	0.006122	1	0
CCDC141	285025	broad.mit.edu	37	2	179702023	179702023	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:179702023T>A	uc002unf.1	-	13	2255	c.2198A>T	c.(2197-2199)AAG>ATG	p.K733M	CCDC141_uc002une.1_Missense_Mutation_p.K183M	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	733							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GGCAGTACTCTTTTCCACGAA	0.478			NA											22	53					0	0	0.001882	0	0
CERKL	375298	broad.mit.edu	37	2	182423388	182423388	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:182423388G>T	uc002unx.2	-	6	904	c.803C>A	c.(802-804)GCT>GAT	p.A268D	CERKL_uc002uny.2_Missense_Mutation_p.A242D|CERKL_uc010zfm.1_Missense_Mutation_p.A224D|CERKL_uc002unz.2_5'UTR|CERKL_uc002uoa.2_Intron|CERKL_uc002uob.2_5'UTR|CERKL_uc002uoc.2_Intron|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Missense_Mutation_p.A37D|CERKL_uc002uoe.2_Missense_Mutation_p.A242D	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	268	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CAGAAGCAAAGCATGGGCTAC	0.453			NA											22	99					1.50039e-11	2.38224e-11	0.001882	1	0
ITGAV	3685	broad.mit.edu	37	2	187529932	187529932	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:187529932A>G	uc002upq.2	+	21	2429	c.2153A>G	c.(2152-2154)AAG>AGG	p.K718R	ITGAV_uc010frs.2_Missense_Mutation_p.K682R|ITGAV_uc010zfv.1_Missense_Mutation_p.K672R	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	718	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		AACCCAATGAAGGCTGGAACT	0.363	Melanoma(58;108 1995 6081)		NA											10	267					0	0	0.000978	0	0
COL3A1	1281	broad.mit.edu	37	2	189862437	189862437	+	Silent	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:189862437T>A	uc002uqj.1	+	27	1998	c.1881T>A	c.(1879-1881)GGT>GGA	p.G627G		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	627	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGCCTGGTGGTGACAAAGGAG	0.383			NA											105	39					0	0	0.00361	0	0
COL5A2	1290	broad.mit.edu	37	2	189899873	189899873	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:189899873A>T	uc002uqk.2	-	53	4397	c.4122T>A	c.(4120-4122)TAT>TAA	p.Y1374*	COL5A2_uc010frx.2_Nonsense_Mutation_p.Y950*	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1374	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGTGGTCTCCATAAGCGAACT	0.348			NA											16	337					0	0	0.007413	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428941	190428941	+	Silent	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:190428941T>A	uc002uqp.3	-	7	1122	c.771A>T	c.(769-771)CCA>CCT	p.P257P		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	257					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CCAGGGGTTTTGGCTCAGTAT	0.418			NA											102	62					0	0	0.00361	0	0
HECW2	57520	broad.mit.edu	37	2	197184519	197184519	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:197184519C>A	uc002utm.1	-	9	1278	c.1095G>T	c.(1093-1095)CAG>CAT	p.Q365H	HECW2_uc002utl.1_Missense_Mutation_p.Q9H	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	365					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity	p.Q365H(1)		skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						TAGAGCACACCTGGCTGTCGT	0.517			NA											14	43					0.000151284	0.000197659	0.001855	1	0
KCTD18	130535	broad.mit.edu	37	2	201363800	201363800	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:201363800G>T	uc002uvs.2	-	4	897	c.380C>A	c.(379-381)ACA>AAA	p.T127K	KCTD18_uc002uvt.2_Missense_Mutation_p.T127K|KCTD18_uc002uvu.1_Missense_Mutation_p.T127K	NM_152387	NP_689600	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain	127						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1						ACAGAAGTCTGTTAAAGCCTA	0.308			NA											25	79					2.39556e-15	4.11711e-15	0.00278	1	0
CTLA4	1493	broad.mit.edu	37	2	204732769	204732769	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:204732769G>A	uc002vak.1	+	1	261	c.104G>A	c.(103-105)TGC>TAC	p.C35Y	CTLA4_uc002val.1_Missense_Mutation_p.C35Y|CTLA4_uc010fty.1_Missense_Mutation_p.C35Y|CTLA4_uc010ftz.1_RNA	NM_005214	NP_005205	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	35					B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm					0					Abatacept(DB01281)	CCTGTCTTCTGCAAAGGTGAG	0.488			NA											22	137					0	0	0.002299	0	0
CTLA4	1493	broad.mit.edu	37	2	204735330	204735330	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:204735330C>T	uc002vak.1	+	2	288	c.131C>T	c.(130-132)GCT>GTT	p.A44V	CTLA4_uc002val.1_Missense_Mutation_p.A44V|CTLA4_uc010fty.1_Missense_Mutation_p.A44V|CTLA4_uc010ftz.1_Intron	NM_005214	NP_005205	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	44	Ig-like V-type.|Extracellular (Potential).				B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm					0					Abatacept(DB01281)	GCCCAGCCTGCTGTGGTACTG	0.582			NA											200	40					0	0	0.00361	0	0
EEF1B2	1933	broad.mit.edu	37	2	207027262	207027263	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:207027262_207027263GG>TT	uc002vbf.1	+	6	605_606	c.447_448GG>TT	c.(445-450)TGGGAT>TGTTAT	p.149_150WD>CY	EEF1B2_uc002vbg.1_Missense_Mutation_p.149_150WD>CY|EEF1B2_uc002vbh.1_Missense_Mutation_p.149_150WD>CY	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	149_150						cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						TGAAACCTTGGGATGATGAGAC	0.391			NA											138	105					0	0	0.004672	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171188	207171188	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:207171188A>G	uc002vbp.2	+	5	2186	c.1936A>G	c.(1936-1938)ATA>GTA	p.I646V		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	646	Potential.						nucleic acid binding|zinc ion binding			ovary(3)	3						TGTTGAAAAGATAAATCTTCT	0.423			NA											17	112					0	0	0.00499	0	0
CRYGC	1420	broad.mit.edu	37	2	208992948	208992948	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:208992948C>A	uc002vco.3	-	3	542	c.504G>T	c.(502-504)CGG>CGT	p.R168R		NM_020989	NP_066269	P07315	CRGC_HUMAN	crystallin, gamma C	168	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		CCACCACTCTCCGCAAAGAGC	0.502			NA											53	216					7.89702e-26	1.56149e-25	0.00361	1	0
MAP2	4133	broad.mit.edu	37	2	210559792	210559792	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:210559792G>T	uc002vde.1	+	7	3146	c.2898G>T	c.(2896-2898)AAG>AAT	p.K966N	MAP2_uc002vdc.1_Missense_Mutation_p.K966N|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.K962N	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	966					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TACTAGAAAAGAGTGAAGAAC	0.403	Pancreas(27;423 979 28787 29963)		NA											34	33					2.42023e-17	4.33832e-17	0.003271	1	0
C2orf67	151050	broad.mit.edu	37	2	210888902	210888902	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:210888902C>A	uc002vds.2	-	14	2796	c.2588G>T	c.(2587-2589)GGA>GTA	p.G863V	C2orf67_uc002vdt.2_Missense_Mutation_p.G821V	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	863										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		CAAGTCCTGTCCTTCAACATT	0.383			NA											10	32					0.000673444	0.000859964	0.008291	1	0
CPS1	1373	broad.mit.edu	37	2	211515147	211515147	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:211515147G>T	uc002vee.3	+	28	3597	c.3465G>T	c.(3463-3465)GCG>GCT	p.A1155A	CPS1_uc010fur.2_Silent_p.A1161A|CPS1_uc010fus.2_Silent_p.A704A	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1155	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TAGAAGAGGCGACTAGAGTTT	0.368			NA											24	32					3.6726e-16	6.41535e-16	0.003954	1	0
WNT6	7475	broad.mit.edu	37	2	219736268	219736268	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:219736268G>T	uc002vjc.1	+	3	578	c.363G>T	c.(361-363)ACG>ACT	p.T121T		NM_006522	NP_006513	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family,	121					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(2)|skin(1)	3		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACGCCGTCACGCAGGCCTGTT	0.473			NA											4	7					5.16669e-11	8.09616e-11	0.000978	1	0
ATG9A	79065	broad.mit.edu	37	2	220087103	220087103	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:220087103G>A	uc002vke.1	-	12	2104	c.1918C>T	c.(1918-1920)CAG>TAG	p.Q640*	ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Nonsense_Mutation_p.Q640*	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	640	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGGAGCCCTGCAGGTCTCTG	0.642			NA											37	24					0	0	0.005524	0	0
SLC4A3	6508	broad.mit.edu	37	2	220505593	220505593	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:220505593C>A	uc002vmp.3	+	22	3799	c.3530C>A	c.(3529-3531)GCC>GAC	p.A1177D	SLC4A3_uc002vmo.3_Missense_Mutation_p.A1204D|SLC4A3_uc010fwm.2_Missense_Mutation_p.A727D	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	1177	Membrane (anion exchange).|Helical; (Potential).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCACGGCGGCCTCACTCGCC	0.642			NA											5	32					1.23904e-05	1.6642e-05	0.000602	1	0
SERPINE2	5270	broad.mit.edu	37	2	224862898	224862898	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:224862898C>A	uc002vnu.2	-	3	664	c.421G>T	c.(421-423)GTG>TTG	p.V141L	SERPINE2_uc002vnt.2_Missense_Mutation_p.V141L|SERPINE2_uc010zlr.1_Missense_Mutation_p.V153L|SERPINE2_uc002vnv.2_Missense_Mutation_p.V141L	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	141					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCAAAGTTCACATTCCGGACC	0.453			NA											8	37					3.09899e-07	4.42251e-07	0.004482	1	0
CCL20	6364	broad.mit.edu	37	2	228681074	228681074	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:228681074G>C	uc002vpl.2	+	3	313	c.243G>C	c.(241-243)TGG>TGC	p.W81C	CCL20_uc002vpm.2_Missense_Mutation_p.W80C	NM_004591	NP_004582	P78556	CCL20_HUMAN	chemokine (C-C motif) ligand 20 isoform 1	81					cell-cell signaling|chemotaxis|defense response to bacterium|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity				0		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;7.3e-11)|all cancers(144;4.13e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		AACAGACTTGGGTGAAATATA	0.398			NA											17	49					0	0	0.008871	0	0
DNER	92737	broad.mit.edu	37	2	230253070	230253070	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:230253070G>T	uc002vpv.2	-	11	1913	c.1766C>A	c.(1765-1767)CCC>CAC	p.P589H		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	589	Extracellular (Potential).|EGF-like 10; calcium-binding (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		ATGGTGGCAGGGGTTACTGTC	0.502			NA											29	85					5.45727e-16	9.51549e-16	0.008361	1	0
NMUR1	10316	broad.mit.edu	37	2	232393341	232393341	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:232393341C>A	uc002vry.3	-	2	501	c.391G>T	c.(391-393)GTT>TTT	p.V131F		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	131	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CAGCCACCAACGCCCAGCAGG	0.612			NA											36	26					2.42023e-17	4.33832e-17	0.003271	1	0
UGT1A3	54659	broad.mit.edu	37	2	234638412	234638412	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:234638412A>T	uc002vuy.2	+	1	640	c.640A>T	c.(640-642)ATG>TTG	p.M214L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.M214L	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	214					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GGTCAAGAACATGCTCTACCC	0.463			NA											58	139					0	0	0.00361	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239237863	239237863	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:239237863G>T	uc002vye.2	+	5	914	c.795G>T	c.(793-795)AGG>AGT	p.R265S	TRAF3IP1_uc002vyf.2_Missense_Mutation_p.R265S	NM_015650	NP_056465	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting	265	Abolishes microtubules-binding when missing.|DISC1-interaction domain.|Arg-rich.					cytoplasm|cytoskeleton	protein binding			ovary(1)	1		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		tgagagacagggaccgagagc	0.109			NA											5	12					0.000602214	0.000770031	0.000602	1	0
FARP2	9855	broad.mit.edu	37	2	242343347	242343347	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:242343347G>C	uc002wbi.1	+	3	405	c.288G>C	c.(286-288)TGG>TGC	p.W96C	FARP2_uc010zoq.1_Missense_Mutation_p.W96C|FARP2_uc010zor.1_Missense_Mutation_p.W96C	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	96	FERM.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		AGTCCTACTGGGTAAGTGCTT	0.468			NA											13	28					0	0	0.001855	0	0
C20orf54	113278	broad.mit.edu	37	20	744613	744613	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:744613C>A	uc002wed.3	-	3	941	c.602G>T	c.(601-603)GGA>GTA	p.G201V	C20orf54_uc002wee.2_Missense_Mutation_p.G201V	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	201					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						TGCTTCCATTCCGGGGAGGGC	0.587			NA											8	14					0.00307968	0.00388096	0.00308	1	0
TMC2	117532	broad.mit.edu	37	20	2597940	2597940	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:2597940T>A	uc002wgf.1	+	16	2178	c.2163T>A	c.(2161-2163)TTT>TTA	p.F721L	TMC2_uc002wgg.1_Missense_Mutation_p.F705L	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	721	Extracellular (Potential).					integral to membrane				ovary(3)	3						CACCCTCCTTTGACTGCGGGC	0.632			NA											5	59					0	0	0.000602	0	0
PAK7	57144	broad.mit.edu	37	20	9561076	9561076	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:9561076G>A	uc002wnl.2	-	5	1251	c.706C>T	c.(706-708)CCT>TCT	p.P236S	PAK7_uc002wnk.2_Missense_Mutation_p.P236S|PAK7_uc002wnj.2_Missense_Mutation_p.P236S|PAK7_uc010gby.1_Missense_Mutation_p.P236S	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	236	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GTTCTAGAAGGTGTGAATTGG	0.517			NA											31	66					0	0	0.001786	0	0
PCSK2	5126	broad.mit.edu	37	20	17462628	17462628	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:17462628G>T	uc002wpm.2	+	12	2150	c.1830G>T	c.(1828-1830)AAG>AAT	p.K610N	PCSK2_uc002wpl.2_Missense_Mutation_p.K591N|PCSK2_uc010zrm.1_Missense_Mutation_p.K575N|PCSK2_uc002wpn.2_Missense_Mutation_p.K264N	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	610					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCAGTCCAAGTTGGCCATGT	0.582			NA											7	32					0.00198382	0.00250656	0.001984	1	0
CST9	128822	broad.mit.edu	37	20	23584167	23584167	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:23584167G>T	uc002wtl.2	-	2	569	c.460C>A	c.(460-462)CCG>ACG	p.P154T		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	154						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					TTGTCCCTCGGAATGGCTTTG	0.582			NA											12	32					4.93089e-13	8.05575e-13	0.00245	1	0
CST9	128822	broad.mit.edu	37	20	23586332	23586332	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:23586332G>A	uc002wtl.2	-	1	279	c.170C>T	c.(169-171)ACT>ATT	p.T57I		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	57						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					CACGTTGAAAGTGTTCAAGGC	0.498			NA											47	210					0	0	0.00361	0	0
NINL	22981	broad.mit.edu	37	20	25450719	25450719	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:25450719A>G	uc002wux.1	-	18	3335	c.3261T>C	c.(3259-3261)CAT>CAC	p.H1087H	NINL_uc010gdn.1_Silent_p.H738H	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1087	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CAGAAAGTCTATGGAACTCCA	0.507			NA									OREG0025846	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	68	120					0	0	0.00361	0	0
C20orf186	149954	broad.mit.edu	37	20	31671678	31671678	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:31671678G>T	uc010zue.1	+	3	690	c.675G>T	c.(673-675)ACG>ACT	p.T225T		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	225	Gly-rich.					cytoplasm|extracellular region	lipid binding				0						AAGGCATCACGGGGTAAGGAG	0.627			NA											26	44					5.61819e-17	1.00146e-16	0.005443	1	0
ZNF341	84905	broad.mit.edu	37	20	32357916	32357916	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:32357916T>A	uc002wzy.2	+	10	1460	c.1440T>A	c.(1438-1440)TGT>TGA	p.C480*	ZNF341_uc002wzx.2_Nonsense_Mutation_p.C473*|ZNF341_uc010geq.2_Nonsense_Mutation_p.C390*|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	480	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCAAAAGCTGTGCCCAGACGT	0.592			NA											11	40					0	0	0.008291	0	0
GDF5	8200	broad.mit.edu	37	20	34021804	34021804	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:34021804C>A	uc002xck.1	-	2	1728	c.1409G>T	c.(1408-1410)CGG>CTG	p.R470L	GDF5_uc010gfc.1_Missense_Mutation_p.R470L|uc002xcj.2_Missense_Mutation_p.P72Q|GDF5_uc010zvc.1_Missense_Mutation_p.R470L	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	470					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GGGACTCAGCCGCGTGGGCAC	0.577			NA											39	38					2.05212e-20	3.87398e-20	0.005524	1	0
EMILIN3	90187	broad.mit.edu	37	20	39991455	39991455	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:39991455G>A	uc002xjy.1	-	4	978	c.754C>T	c.(754-756)CTA>TTA	p.L252L		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	252						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				ACCTTGCTTAGGATCTCGTCT	0.602			NA											23	34					0	0	0.00278	0	0
PTPRT	11122	broad.mit.edu	37	20	40714398	40714398	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:40714398G>A	uc002xkg.2	-	28	4126	c.3942C>T	c.(3940-3942)CAC>CAT	p.H1314H	PTPRT_uc010ggj.2_Silent_p.H1333H|PTPRT_uc010ggi.2_Silent_p.H517H	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1314	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.T1314A(1)		skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGAATATTCTGTGGATGATGT	0.577			NA											56	58					0	0	0.00361	0	0
L3MBTL	26013	broad.mit.edu	37	20	42159463	42159463	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:42159463G>T	uc010zwh.1	+	11	1198	c.1152G>T	c.(1150-1152)TGG>TGT	p.W384C	L3MBTL_uc002xkl.2_Missense_Mutation_p.W316C|L3MBTL_uc002xkm.2_Missense_Mutation_p.W316C|L3MBTL_uc010ggl.2_Missense_Mutation_p.W316C|L3MBTL_uc002xkn.1_Missense_Mutation_p.W75C|L3MBTL_uc002xko.2_5'Flank	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	316	MBT 2.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AGTTCAGCTGGAGCCAGTACC	0.622			NA											16	33					3.41278e-10	5.2788e-10	0.00499	1	0
MYBL2	4605	broad.mit.edu	37	20	42331433	42331433	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:42331433G>T	uc002xlb.1	+	8	1470	c.1255G>T	c.(1255-1257)GCT>TCT	p.A419S	MYBL2_uc010zwj.1_Missense_Mutation_p.A395S|MYBL2_uc002xla.1_Missense_Mutation_p.A419S	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	419						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAGGCGTGTGGCTCTGTCCCC	0.612			NA											36	37					4.34311e-12	6.91867e-12	0.003271	1	0
SLC12A5	57468	broad.mit.edu	37	20	44664148	44664148	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:44664148G>A	uc010zxl.1	+	3	398	c.322G>A	c.(322-324)GAG>AAG	p.E108K	SLC12A5_uc002xra.2_Missense_Mutation_p.E85K|SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.E85K	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	108	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGAAAACAATGAGGGTGGAAA	0.398			NA											37	65					0	0	0.004878	0	0
SLC12A5	57468	broad.mit.edu	37	20	44674636	44674636	+	Splice_Site	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:44674636G>A	uc010zxl.1	+	13	1833	c.1757_splice	c.e13+1	p.M586_splice	SLC12A5_uc010zxm.1_Splice_Site|SLC12A5_uc002xrb.2_Splice_Site_p.M563_splice	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride						potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCTCTCTATGTGCGTGCCTG	0.582			NA											80	181					0	0	0.00361	0	0
SULF2	55959	broad.mit.edu	37	20	46331302	46331302	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:46331302C>A	uc002xto.2	-	4	858	c.528G>T	c.(526-528)CGG>CGT	p.R176R	SULF2_uc002xtr.2_Silent_p.R176R|SULF2_uc002xtq.2_Silent_p.R176R|SULF2_uc010ghv.1_Silent_p.R176R	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	176					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TCACCCCGTTCCGACACAGCG	0.458			NA											16	32					4.7546e-09	7.12448e-09	0.004007	1	0
PREX1	57580	broad.mit.edu	37	20	47307504	47307504	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:47307504G>T	uc002xtw.1	-	9	1190	c.1167C>A	c.(1165-1167)CGC>CGA	p.R389R		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	389	PH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCTCCCGCTCGCGGATGATGG	0.592			NA											40	47					2.51966e-14	4.21702e-14	0.00361	1	0
PTPN1	5770	broad.mit.edu	37	20	49177900	49177900	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:49177900G>T	uc002xvl.2	+	2	238	c.64G>T	c.(64-66)GAT>TAT	p.D22Y	PTPN1_uc010zys.1_Intron	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	22	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	TTTTTTGTAGGATATCCGACA	0.443			NA											25	45					4.47668e-21	8.50126e-21	0.003954	1	0
CBLN4	140689	broad.mit.edu	37	20	54579055	54579055	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:54579055G>T	uc002xxa.2	-	1	958	c.173C>A	c.(172-174)TCC>TAC	p.S58Y		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	58						cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			CCCCAGCGGGGAGGAAGAGGA	0.657			NA											37	46					1.06647e-15	1.8528e-15	0.003755	1	0
SYCP2	10388	broad.mit.edu	37	20	58461890	58461890	+	Splice_Site	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:58461890C>T	uc002yaz.2	-	24	2504	c.2365_splice	c.e24-1	p.R789_splice		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2						cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ACTTTTCTCTCTGAAAAAAAT	0.269			NA											25	26					0	0	0.00278	0	0
C20orf177	63939	broad.mit.edu	37	20	58519910	58519910	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:58519910G>T	uc002yba.2	+	5	1327	c.912G>T	c.(910-912)CAG>CAT	p.Q304H	C20orf177_uc010zzx.1_Missense_Mutation_p.Q147H|C20orf177_uc002ybc.2_Missense_Mutation_p.Q304H	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	304										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)			CGAAGCTGCAGCGCTGGGATC	0.483			NA											25	53					9.86323e-18	1.78133e-17	0.003954	1	0
DIDO1	11083	broad.mit.edu	37	20	61542745	61542745	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:61542745C>A	uc002ydr.1	-	3	484	c.220G>T	c.(220-222)GTG>TTG	p.V74L	DIDO1_uc002yds.1_Missense_Mutation_p.V74L|DIDO1_uc002ydt.1_Missense_Mutation_p.V74L|DIDO1_uc002ydu.1_Missense_Mutation_p.V74L|DIDO1_uc002ydv.1_Missense_Mutation_p.V74L|DIDO1_uc002ydw.1_Missense_Mutation_p.V74L|DIDO1_uc002ydx.1_Missense_Mutation_p.V74L|DIDO1_uc011aao.1_Missense_Mutation_p.V74L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	74					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					AACTGCTCCACGCGCTCAGTG	0.711	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											18	20					1.33834e-09	2.0308e-09	0.007413	1	0
COL20A1	57642	broad.mit.edu	37	20	61959818	61959818	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:61959818G>A	uc011aau.1	+	34	3849	c.3749G>A	c.(3748-3750)TGG>TAG	p.W1250*	COL20A1_uc011aav.1_Nonsense_Mutation_p.W1077*	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1250					cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					CCTGGAGAATGGGGGCGTGGT	0.701			NA											11	18					0	0	0.00245	0	0
NCAM2	4685	broad.mit.edu	37	21	22881243	22881243	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr21:22881243G>C	uc002yld.1	+	16	2398	c.2149G>C	c.(2149-2151)GTG>CTG	p.V717L	NCAM2_uc011acb.1_Missense_Mutation_p.V575L	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	717	Helical; (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GCTAATTCTTGTGGTAACAGA	0.418			NA											30	8					0	0	0.003271	0	0
IL10RB	3588	broad.mit.edu	37	21	34655489	34655489	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr21:34655489G>C	uc002yrk.1	+	5	688	c.589G>C	c.(589-591)GAT>CAT	p.D197H	IL10RB_uc002yrh.1_Missense_Mutation_p.D267H|IL10RB_uc002yri.1_Missense_Mutation_p.D150H|IL10RB_uc002yrl.1_Missense_Mutation_p.D199H	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	197	Fibronectin type-III.|Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						GTTTCTTCCTGATCGGAACAA	0.478	Melanoma(67;315 1275 21667 21943 44564)		NA											3	44					0	0	0.004672	0	0
IFNAR1	3454	broad.mit.edu	37	21	34721562	34721562	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr21:34721562G>T	uc002yrn.2	+	7	1101	c.954G>T	c.(952-954)TGG>TGT	p.W318C	IFNAR1_uc011adv.1_Missense_Mutation_p.W249C	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	318	Fibronectin type-III 2.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CATCTTTTTGGTCTGAAGAGA	0.343	Esophageal Squamous(73;817 1211 32990 35667 42746)		NA											47	9					3.21987e-24	6.25072e-24	0.00361	1	0
PCNT	5116	broad.mit.edu	37	21	47754463	47754463	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr21:47754463A>G	uc002zji.3	+	3	527	c.420A>G	c.(418-420)CCA>CCG	p.P140P	PCNT_uc002zjj.2_Silent_p.P22P|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	140					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					ACCACCCACCAGAACAGCGTG	0.542			NA											3	47					0	0	0.000248	0	0
PRODH	5625	broad.mit.edu	37	22	18918567	18918567	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:18918567C>T	uc010grl.2	-	2	432	c.418G>A	c.(418-420)GCC>ACC	p.A140T	PRODH_uc002zoj.3_Missense_Mutation_p.A30T|PRODH_uc002zol.3_Missense_Mutation_p.A30T|PRODH_uc002zok.3_Missense_Mutation_p.A140T	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	140					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	TCCAGGATGGCGCTGACACCG	0.597			NA											11	48					0	0	0.008291	0	0
SEZ6L	23544	broad.mit.edu	37	22	26747120	26747120	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:26747120G>T	uc003acb.2	+	12	2666	c.2510G>T	c.(2509-2511)GGT>GTT	p.G837V	SEZ6L_uc003acc.2_Missense_Mutation_p.G837V|SEZ6L_uc011akc.1_Missense_Mutation_p.G837V|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Missense_Mutation_p.G837V|SEZ6L_uc003ace.2_Missense_Mutation_p.G837V|SEZ6L_uc003acf.1_Missense_Mutation_p.G610V|SEZ6L_uc010gvc.1_Missense_Mutation_p.G610V|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	837	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TGCAACCCCGGTTTTGTGCTT	0.572			NA											12	34					2.27111e-07	3.25074e-07	0.001368	1	0
MN1	4330	broad.mit.edu	37	22	28146947	28146947	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:28146947C>T	uc003adj.2	-	2	4874	c.3919G>A	c.(3919-3921)GAC>AAC	p.D1307N	MN1_uc010gvg.2_RNA	NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1307							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						TTGGAGATGTCAGAATGCAGG	0.458			NA	T	ETV6	AML|meningioma								16	24					0	0	0.004007	0	0
INPP5J	27124	broad.mit.edu	37	22	31529925	31529925	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:31529925C>A	uc003aju.3	+	13	2633	c.2541C>A	c.(2539-2541)GCC>GCA	p.A847A	INPP5J_uc003ajv.3_Silent_p.A480A|INPP5J_uc003ajs.3_Silent_p.A480A|INPP5J_uc011alk.1_Silent_p.A780A|INPP5J_uc010gwg.2_Silent_p.A412A|INPP5J_uc003ajw.2_3'UTR|INPP5J_uc003ajt.3_Silent_p.A479A|INPP5J_uc003ajx.2_Silent_p.A212A|INPP5J_uc003ajy.2_Silent_p.A186A|INPP5J_uc003ajz.2_Silent_p.A287A	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	847	Ser-rich.					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						CGGAGTTGGCCAGCAGCAGCA	0.647			NA											15	19					3.32936e-07	4.74421e-07	0.006122	1	0
MCM5	4174	broad.mit.edu	37	22	35806852	35806852	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:35806852C>T	uc003anu.3	+	7	962	c.868C>T	c.(868-870)CGA>TGA	p.R290*	MCM5_uc010gwr.2_Nonsense_Mutation_p.R99*|MCM5_uc003anv.3_Nonsense_Mutation_p.R247*|MCM5_uc010gws.1_RNA|MCM5_uc003anw.1_Nonsense_Mutation_p.R74*	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	290					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						CGTGGGCATCCGAAGCTCCTA	0.557			NA											12	26					0	0	0.000978	0	0
RPL3	6122	broad.mit.edu	37	22	39713540	39713540	+	Silent	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:39713540T>A	uc003axi.2	-	3	359	c.291A>T	c.(289-291)CGA>CGT	p.R97R	RPL3_uc003axh.2_Silent_p.R97R|RPL3_uc003axj.2_5'UTR|RPL3_uc011aoj.1_Silent_p.R97R|RPL3_uc010gxx.2_Silent_p.R45R|RPL3_uc003axg.2_Silent_p.R45R|RPL3_uc003axk.1_5'UTR	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	97					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					TCCGGAGGCCTCGAGGGGTTT	0.532			NA											35	79					0	0	0.002836	0	0
TCF20	6942	broad.mit.edu	37	22	42607645	42607645	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:42607645G>C	uc003bcj.1	-	1	3801	c.3667C>G	c.(3667-3669)CTA>GTA	p.L1223V	TCF20_uc003bck.1_Missense_Mutation_p.L1223V|TCF20_uc003bnt.2_Missense_Mutation_p.L1223V	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GCCTCAGCTAGTCCATGTCCA	0.512			NA											19	23					0	0	0.006122	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655173	46655173	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:46655173A>T	uc003bhh.2	-	1	4047	c.4047T>A	c.(4045-4047)GAT>GAA	p.D1349E		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1349	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TCAGACGCTCATCTGGATGGG	0.388			NA											5	60					0	0	0.000602	0	0
SHANK3	85358	broad.mit.edu	37	22	51160861	51160861	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr22:51160861G>T	uc003bne.1	+	22	4648	c.4648G>T	c.(4648-4650)GCT>TCT	p.A1550S	SHANK3_uc003bnf.1_Missense_Mutation_p.A997S|SHANK3_uc010hbg.1_Missense_Mutation_p.A732S	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1550										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CATCGCAGCAGCTCGGTGAGC	0.637			NA											14	12					1.99824e-07	2.86873e-07	0.00499	1	0
SLC6A11	6538	broad.mit.edu	37	3	10916777	10916777	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:10916777C>A	uc003bvz.2	+	6	922	c.888C>A	c.(886-888)CCC>CCA	p.P296P		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	296					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTCCGACCCCCAGGTAAGAG	0.592			NA											29	9					7.26314e-15	1.23063e-14	0.007291	1	0
FBLN2	2199	broad.mit.edu	37	3	13612322	13612322	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:13612322C>T	uc011avb.1	+	2	592	c.467C>T	c.(466-468)CCC>CTC	p.P156L	FBLN2_uc011auz.1_Missense_Mutation_p.P182L|FBLN2_uc011ava.1_Missense_Mutation_p.P156L|FBLN2_uc011avc.1_Missense_Mutation_p.P156L	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	156	Subdomain NA (Cys-rich).|N.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CACCTGCCGCCCTGCCGGGCC	0.687			NA											7	2					0	0	0.004482	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15124018	15124018	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:15124018G>A	uc003bzm.1	-	9	1310	c.696C>T	c.(694-696)AGC>AGT	p.S232S	ZFYVE20_uc010hek.1_Silent_p.S232S|ZFYVE20_uc011avn.1_Intron	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	232	FYVE-type.|Ser-rich.|Necessary for the correct targeting to endosomes.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						TGCTCATGCTGCTGATGCTGC	0.607			NA											32	13					0	0	0.002836	0	0
SUSD5	26032	broad.mit.edu	37	3	33194435	33194435	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:33194435C>A	uc003cfo.1	-	5	2107	c.1689G>T	c.(1687-1689)GTG>GTT	p.V563V		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	563	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						ATCCGTCCCCCACACACGACT	0.607			NA											8	14					1.12685e-05	1.52204e-05	0.004482	1	0
ARPP21	10777	broad.mit.edu	37	3	35778760	35778760	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:35778760C>A	uc003cgb.2	+	16	1814	c.1550C>A	c.(1549-1551)TCC>TAC	p.S517Y	ARPP21_uc003cga.2_Missense_Mutation_p.S463Y|ARPP21_uc011axy.1_Missense_Mutation_p.S483Y|ARPP21_uc003cgf.2_Missense_Mutation_p.S318Y|ARPP21_uc003cgg.2_Missense_Mutation_p.S5Y	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	517	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GTGGGGCAGTCCCAACAGCAG	0.637			NA											19	17					8.00594e-06	1.08749e-05	0.007413	1	0
CCR3	1232	broad.mit.edu	37	3	46307665	46307665	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:46307665C>G	uc003cpg.1	+	4	1559	c.1016C>G	c.(1015-1017)ACC>AGC	p.T339S	CCR3_uc003cpi.1_Missense_Mutation_p.T339S|CCR3_uc003cpj.1_Missense_Mutation_p.T339S|CCR3_uc003cpk.1_Missense_Mutation_p.T360S|CCR3_uc010hjb.1_Missense_Mutation_p.T357S|CCR3_uc003cpl.1_Missense_Mutation_p.T372S	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	339	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CTGGAAAGAACCAGCTCTGTC	0.507			NA											11	14					0	0	0.008291	0	0
QARS	5859	broad.mit.edu	37	3	49135913	49135913	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:49135913C>A	uc003cvx.2	-	21	1962	c.1957G>T	c.(1957-1959)GGC>TGC	p.G653C	QARS_uc011bcc.1_Missense_Mutation_p.G106C|QARS_uc011bcd.1_Missense_Mutation_p.G508C|QARS_uc003cvy.2_Missense_Mutation_p.G508C|QARS_uc011bce.1_Missense_Mutation_p.G642C	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	653					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	CCACTGGGGCCCTGGAAGTGG	0.572			NA											30	11					2.08457e-15	3.60198e-15	0.002096	1	0
QARS	5859	broad.mit.edu	37	3	49137018	49137018	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:49137018T>A	uc003cvx.2	-	16	1456	c.1451A>T	c.(1450-1452)TAT>TTT	p.Y484F	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Missense_Mutation_p.Y339F|QARS_uc003cvy.2_Missense_Mutation_p.Y339F|QARS_uc011bce.1_Missense_Mutation_p.Y473F	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	484					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GAGGCGGCCATACTCCCACTG	0.552			NA											35	5					0	0	0.002836	0	0
USP19	10869	broad.mit.edu	37	3	49149022	49149022	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:49149022C>G	uc003cwd.1	-	20	2980	c.2819G>C	c.(2818-2820)AGC>ACC	p.S940T	USP19_uc003cwa.2_Missense_Mutation_p.S748T|USP19_uc003cvz.3_Missense_Mutation_p.S1043T|USP19_uc011bcg.1_Missense_Mutation_p.S1031T|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.S698T|USP19_uc011bch.1_Missense_Mutation_p.S1041T	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	940	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCCACTGGTGCTGGGCACAGG	0.642			NA											26	4					0	0	0.003954	0	0
DNAH1	25981	broad.mit.edu	37	3	52428648	52428648	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:52428648G>T	uc011bef.1	+	67	11055	c.10794G>T	c.(10792-10794)CGG>CGT	p.R3598R	DNAH1_uc003ddv.2_Silent_p.R456R	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3663					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGAATTCCGGGTCATCTTCG	0.577			NA											26	3					4.87955e-14	8.0542e-14	0.005443	1	0
ITIH1	3697	broad.mit.edu	37	3	52812520	52812520	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:52812520C>A	uc003dfs.2	+	3	327	c.303C>A	c.(301-303)GCC>GCA	p.A101A	ITIH1_uc010hmn.1_RNA	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	101	VIT.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GTGACTTTGCCGTGTGCGTGC	0.547			NA											34	8					8.73648e-17	1.54867e-16	0.004289	1	0
FRMD4B	23150	broad.mit.edu	37	3	69230592	69230592	+	Missense_Mutation	SNP	T	T	G	rs148389023	by1000genomes	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:69230592T>G	uc003dnv.2	-	21	2599	c.2309A>C	c.(2308-2310)AAT>ACT	p.N770T	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_Missense_Mutation_p.N422T|FRMD4B_uc011bga.1_Missense_Mutation_p.N614T	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	770						cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		AGTAGAAACATTCTGTTTCTT	0.493			NA											3	50					0	0	0.004672	0	0
CADM2	253559	broad.mit.edu	37	3	85961612	85961612	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:85961612G>T	uc003dqj.2	+	5	1218	c.592G>T	c.(592-594)GGA>TGA	p.G198*	CADM2_uc003dqk.2_Nonsense_Mutation_p.G207*|CADM2_uc003dql.2_Nonsense_Mutation_p.G200*	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	198	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GAGTGATGATGGAGTGGCGGT	0.453			NA											20	7					1.87028e-06	2.59566e-06	0.001882	1	0
GABRR3	200959	broad.mit.edu	37	3	97744491	97744491	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:97744491C>G	uc011bgr.1	-	2	158	c.158G>C	c.(157-159)AGT>ACT	p.S53T		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	53	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0						CGCTTTGGTACTGTCATCTTT	0.388			NA											16	8					0	0	0.004007	0	0
GPR128	84873	broad.mit.edu	37	3	100374024	100374024	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:100374024G>T	uc003duc.2	+	12	1993	c.1725G>T	c.(1723-1725)TGG>TGT	p.W575C	GPR128_uc011bhc.1_Missense_Mutation_p.W276C|GPR128_uc003dud.2_Missense_Mutation_p.W98C	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	575	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TAATTGGATGGGGTAAGTGTT	0.318	Pancreas(87;185 1975 7223 18722)		NA											54	10					2.73381e-35	5.72428e-35	0.00361	1	0
CBLB	868	broad.mit.edu	37	3	105412398	105412398	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:105412398T>C	uc003dwc.2	-	13	2316	c.1994A>G	c.(1993-1995)TAT>TGT	p.Y665C	CBLB_uc011bhi.1_Missense_Mutation_p.Y687C|CBLB_uc003dwd.1_Missense_Mutation_p.Y665C|CBLB_uc003dwe.1_Missense_Mutation_p.Y665C	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	665	Pro-rich.			Y->F: Slightly inhibits interaction with CRKL. Abolishes interaction with CRKL; when associated with F-709.	cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AGGAACATCATATTCTTCACT	0.418	GBM(93;588 1337 9788 29341 43499)		NA	Mis S		AML								33	6					0	0	0.005524	0	0
SIDT1	54847	broad.mit.edu	37	3	113325904	113325904	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:113325904G>C	uc003eak.2	+	15	2072	c.1421G>C	c.(1420-1422)GGC>GCC	p.G474A	SIDT1_uc011bif.1_Intron|SIDT1_uc003eaj.1_Missense_Mutation_p.G474A|SIDT1_uc011big.1_Missense_Mutation_p.G227A|SIDT1_uc011bih.1_Intron|SIDT1_uc011bii.1_Intron	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	474	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						AATGTCACTGGCAACCAGGAC	0.512			NA											22	23					0	0	0.00632	0	0
B4GALT4	8702	broad.mit.edu	37	3	118937606	118937606	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:118937606C>G	uc003ecg.2	-	6	1329	c.688G>C	c.(688-690)GGA>CGA	p.G230R	B4GALT4_uc003ece.1_Missense_Mutation_p.G230R|B4GALT4_uc003ecf.2_RNA|B4GALT4_uc003ech.2_Missense_Mutation_p.G230R|B4GALT4_uc003eci.2_Missense_Mutation_p.G230R|B4GALT4_uc011biy.1_RNA	NM_212543	NP_997708	O60513	B4GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	230	Lumenal (Potential).				membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity				0				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)	CCAAAATATCCACTGTAACGT	0.473			NA											6	98					0	0	0.00308	0	0
STXBP5L	9515	broad.mit.edu	37	3	120871407	120871407	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:120871407G>T	uc003eec.3	+	8	893	c.753G>T	c.(751-753)GAG>GAT	p.E251D	STXBP5L_uc011bji.1_Missense_Mutation_p.E251D	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	251					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		ATTATGATGAGGTAAGTGATT	0.353			NA											40	7					1.22674e-20	2.32499e-20	0.00874	1	0
COL6A6	131873	broad.mit.edu	37	3	130282295	130282295	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:130282295G>A	uc010htl.2	+	2	479	c.448G>A	c.(448-450)GCA>ACA	p.A150T		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	150	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TGTGGAAGAGGCATCAAAGGC	0.493			NA											28	10					0	0	0.00632	0	0
CPNE4	131034	broad.mit.edu	37	3	131442447	131442447	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:131442447C>G	uc003eok.2	-	3	638	c.203G>C	c.(202-204)CGC>CCC	p.R68P	CPNE4_uc011blq.1_Missense_Mutation_p.R86P|CPNE4_uc003eol.2_Missense_Mutation_p.R86P|CPNE4_uc003eom.2_Missense_Mutation_p.R68P	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	68	C2 1.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TATGCAGGTGCGAATCACCTC	0.428			NA											30	92					0	0	0.002096	0	0
ACAD11	84129	broad.mit.edu	37	3	132360964	132360964	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:132360964C>T	uc003eov.3	-	4	769	c.389G>A	c.(388-390)CGT>CAT	p.R130H	ACAD11_uc003eoy.2_Missense_Mutation_p.R130H	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	130						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						TGTTAAATCACGGAAGATTCG	0.363			NA											25	79					0	0	0.00632	0	0
MRPS22	56945	broad.mit.edu	37	3	139065733	139065733	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:139065733C>G	uc003etb.2	+	2	194	c.186C>G	c.(184-186)AGC>AGG	p.S62R	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.S61R|MRPS22_uc003ete.2_Missense_Mutation_p.S21R	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	62						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						AATCTGGTAGCCCAGAGACCA	0.363			NA											103	8					0	0	0.00361	0	0
ATR	545	broad.mit.edu	37	3	142272147	142272147	+	Silent	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:142272147T>C	uc003eux.3	-	13	2849	c.2727A>G	c.(2725-2727)ACA>ACG	p.T909T		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	909					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTCTAATTTCTGTGTATGCTG	0.413			NA						Other_conserved_DNA_damage_response_genes					115	14					0	0	0.00361	0	0
MED12L	116931	broad.mit.edu	37	3	150840728	150840728	+	Silent	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:150840728A>T	uc003eyp.2	+	3	401	c.363A>T	c.(361-363)GCA>GCT	p.A121A	MED12L_uc011bnz.1_Silent_p.A121A|MED12L_uc003eym.1_Silent_p.A121A|MED12L_uc003eyn.2_Silent_p.A121A|MED12L_uc003eyo.2_Silent_p.A121A	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	121					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGACTTAGCAGGAAATAAGC	0.343			NA											27	9					0	0	0.008361	0	0
PHC3	80012	broad.mit.edu	37	3	169846735	169846735	+	Missense_Mutation	SNP	T	T	C	rs113283659		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:169846735T>C	uc010hws.1	-	8	1553	c.1489A>G	c.(1489-1491)ATC>GTC	p.I497V	PHC3_uc003fgl.2_Missense_Mutation_p.I509V|PHC3_uc011bpq.1_Missense_Mutation_p.I456V|PHC3_uc011bpr.1_Missense_Mutation_p.I423V	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	497	Pro-rich.|Gln-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GCAATTGGGATTGGAGAGGAC	0.512			NA											3	57					0	0	0.004672	0	0
PRKCI	5584	broad.mit.edu	37	3	169985720	169985720	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:169985720G>T	uc003fgs.2	+	5	620	c.382G>T	c.(382-384)GGT>TGT	p.G128C		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	128	Regulatory domain.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CTACCGTAGAGGTGCACGCCG	0.363			NA											27	6					2.61193e-14	4.36384e-14	0.001786	1	0
SPATA16	83893	broad.mit.edu	37	3	172607409	172607409	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:172607409C>A	uc003fin.3	-	11	1819	c.1661G>T	c.(1660-1662)CGA>CTA	p.R554L		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	554					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TTTTTGCCTTCGAGCAGTTCT	0.378			NA											93	23					5.95195e-44	1.27694e-43	0.00361	1	0
CHRD	8646	broad.mit.edu	37	3	184106393	184106393	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:184106393C>A	uc003fov.2	+	21	2819	c.2573C>A	c.(2572-2574)CCC>CAC	p.P858H	CHRD_uc003fow.2_Missense_Mutation_p.P488H|CHRD_uc003fox.2_Missense_Mutation_p.P858H|CHRD_uc003foy.2_Missense_Mutation_p.P488H|CHRD_uc010hyc.2_Missense_Mutation_p.P448H|CHRD_uc011brr.1_Missense_Mutation_p.P400H	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	858					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGGGCCCACCCCCAGCTGGGG	0.607			NA											62	18					3.05417e-18	5.5896e-18	0.00361	1	0
C3orf65	646600	broad.mit.edu	37	3	185434484	185434484	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:185434484C>T	uc003fpr.2	+	2	493	c.317C>T	c.(316-318)GCC>GTC	p.A106V	IGF2BP2_uc010hyi.2_Intron|IGF2BP2_uc010hyj.2_Intron|IGF2BP2_uc010hyk.2_Intron|IGF2BP2_uc010hyl.2_Intron|IGF2BP2_uc003fpo.2_Intron|IGF2BP2_uc003fpp.2_Intron|IGF2BP2_uc003fpq.2_Intron|C3orf65_uc003fps.3_Intron	NR_027317				RecName: Full=Putative uncharacterized protein C3orf65;												0	all_cancers(143;1.5e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTACTCAGGGCCATGGTGGTG	0.547			NA											20	28					0	0	0.001523	0	0
RFC4	5984	broad.mit.edu	37	3	186522453	186522453	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:186522453G>C	uc003fqz.2	-	2	273	c.50C>G	c.(49-51)ACC>AGC	p.T17S	RFC4_uc011bsc.1_Missense_Mutation_p.T17S|RFC4_uc011bsd.1_Missense_Mutation_p.T17S	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	17					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TCGATCCTTGGTCAGCGGGGG	0.458			NA											79	25					0	0	0.00361	0	0
DLG1	1739	broad.mit.edu	37	3	196842896	196842896	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:196842896C>A	uc003fxo.3	-	14	1634	c.1444G>T	c.(1444-1446)GGA>TGA	p.G482*	DLG1_uc011bub.1_Nonsense_Mutation_p.G366*|DLG1_uc011buc.1_Nonsense_Mutation_p.G366*|DLG1_uc011bud.1_Nonsense_Mutation_p.G165*|DLG1_uc003fxn.3_Nonsense_Mutation_p.G482*|DLG1_uc011bue.1_Nonsense_Mutation_p.G449*|DLG1_uc010ial.2_Nonsense_Mutation_p.G482*|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Nonsense_Mutation_p.G449*|DLG1_uc010ian.2_Nonsense_Mutation_p.G349*	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	482	PDZ 3.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TCTTCTCCTCCTACAATGTTG	0.373			NA											108	15					1.81142e-54	3.93021e-54	0.00361	1	0
ZNF595	152687	broad.mit.edu	37	4	59439	59439	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:59439G>T	uc003fzv.1	+	2	276	c.120G>T	c.(118-120)CTG>CTT	p.L40L	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Silent_p.L40L|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	40					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		ACAGGAACCTGGTCTCCCTGG	0.443			NA											31	423					9.04072e-19	1.66412e-18	0.003271	1	0
BOD1L	259282	broad.mit.edu	37	4	13601180	13601180	+	Silent	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:13601180T>C	uc003gmz.1	-	10	7461	c.7344A>G	c.(7342-7344)GGA>GGG	p.G2448G	BOD1L_uc010idr.1_Silent_p.G1785G	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2448							DNA binding			ovary(5)|breast(1)	6						TCTCTTTCTGTCCTCTTCCTG	0.483			NA									OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	33					0	0	0.007413	0	0
ARAP2	116984	broad.mit.edu	37	4	36161118	36161118	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:36161118C>A	uc003gsq.1	-	14	2790	c.2452G>T	c.(2452-2454)GCT>TCT	p.A818S		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	818					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						ACTACAGCAGCACATAGAGCC	0.413			NA											29	11					5.60225e-13	9.10603e-13	0.001786	1	0
PDGFRA	5156	broad.mit.edu	37	4	55140718	55140718	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:55140718G>T	uc003han.3	+	11	1910	c.1579G>T	c.(1579-1581)GTG>TTG	p.V527L	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.V421L|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_5'Flank	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	527	Helical; (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGAACTCACGGTGGCTGCTGC	0.478	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			53	10					1.0442e-30	2.1489e-30	0.00361	1	0
LPHN3	23284	broad.mit.edu	37	4	62598529	62598529	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:62598529C>A	uc010ihh.2	+	5	625	c.452C>A	c.(451-453)TCC>TAC	p.S151Y	LPHN3_uc003hcq.3_Missense_Mutation_p.S151Y|LPHN3_uc010ihg.1_Missense_Mutation_p.S219Y|LPHN3_uc003hcs.1_5'UTR	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	151	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TTGTTTGAGTCCGACCACCAA	0.408			NA											5	3					0.00116845	0.00148613	0.001168	1	0
TECRL	253017	broad.mit.edu	37	4	65165692	65165692	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:65165692C>A	uc003hcv.2	-	8	883	c.774G>T	c.(772-774)CTG>CTT	p.L258L		NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	258					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TGATACATACCAGAAAATTGA	0.294			NA											37	51					8.16277e-20	1.52002e-19	0.006999	1	0
EPHA5	2044	broad.mit.edu	37	4	66509116	66509117	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:66509116_66509117CC>AT	uc003hcy.2	-	2	403_404	c.210_211GG>AT	c.(208-213)ATGGGG>ATATGG	p.70_71MG>IW	EPHA5_uc003hcx.2_Missense_Mutation_p.1_2MG>IW|EPHA5_uc003hcz.2_Missense_Mutation_p.70_71MG>IW|EPHA5_uc011cah.1_Missense_Mutation_p.70_71MG>IW|EPHA5_uc011cai.1_Missense_Mutation_p.70_71MG>IW|EPHA5_uc003hda.2_Missense_Mutation_p.70_71MG>IW	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	70_71	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CCCAGGTCCCCCATGACAGTGC	0.322			NA								TSP Lung(17;0.13)			34	13					0	0	0.004672	0	0
SHROOM3	57619	broad.mit.edu	37	4	77700208	77700208	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:77700208C>T	uc011cbx.1	+	11	6822	c.5869C>T	c.(5869-5871)CCC>TCC	p.P1957S	SHROOM3_uc003hkg.2_Missense_Mutation_p.P1735S	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1957	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GGAGAGCCTGCCCTCAGATTT	0.562			NA											53	18					0	0	0.00361	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86921657	86921657	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:86921657G>A	uc003hpk.2	+	10	2478	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K	ARHGAP24_uc003hpl.2_Missense_Mutation_p.E582K|ARHGAP24_uc010ikf.2_Missense_Mutation_p.E592K|ARHGAP24_uc003hpm.2_Missense_Mutation_p.E584K	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	677	Potential.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CTTGACTTTGGAAACAGAAAT	0.423			NA											30	12					0	0	0.002096	0	0
SNCA	6622	broad.mit.edu	37	4	90650401	90650401	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:90650401T>A	uc003hsq.2	-	5	593	c.334A>T	c.(334-336)ATT>TTT	p.I112F	SNCA_uc010ikt.2_Missense_Mutation_p.I98F|SNCA_uc003hso.2_Intron|SNCA_uc003hsp.2_Missense_Mutation_p.I112F|SNCA_uc003hsr.2_Missense_Mutation_p.I112F|uc011cdr.1_5'Flank	NM_001146054	NP_001139526	P37840	SYUA_HUMAN	alpha-synuclein isoform NACP140	112					activation of caspase activity|anti-apoptosis|negative regulation of dopamine uptake|negative regulation of exocytosis|negative regulation of histone acetylation|negative regulation of microtubule polymerization|negative regulation of monooxygenase activity|negative regulation of norepinephrine uptake|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of serotonin uptake|negative regulation of thrombin receptor signaling pathway|negative regulation of transporter activity|positive regulation of endocytosis|positive regulation of inositol phosphate biosynthetic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein serine/threonine kinase activity|positive regulation of receptor recycling|positive regulation of release of sequestered calcium ion into cytosol|receptor internalization|regulation of phospholipase activity|response to interferon-gamma|response to interleukin-1|response to iron(II) ion|response to lipopolysaccharide|response to magnesium ion|synaptic vesicle endocytosis	actin cytoskeleton|axon|cell cortex|cell junction|cytosol|fibril|growth cone|nucleus|synapse	alpha-tubulin binding|calcium ion binding|caspase inhibitor activity|dynein binding|ferrous iron binding|histone binding|Hsp70 protein binding|kinesin binding|magnesium ion binding|phosphoprotein binding|tau protein binding|zinc ion binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.42e-05)	Melatonin(DB01065)	TCTTCCAGAATTCCTTCCTGT	0.269			NA											25	7					0	0	0.007291	0	0
MTTP	4547	broad.mit.edu	37	4	100521876	100521876	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:100521876C>T	uc003hvc.3	+	10	1478	c.1222C>T	c.(1222-1224)CTG>TTG	p.L408L	MTTP_uc011cej.1_Silent_p.L435L	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	408	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TGAAGAACTCCTGAGAGCCCT	0.358			NA											20	30					0	0	0.001523	0	0
TACR3	6870	broad.mit.edu	37	4	104512726	104512726	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:104512726G>T	uc003hxe.1	-	4	1146	c.1003C>A	c.(1003-1005)CAG>AAG	p.Q335K		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	335	Helical; Name=7; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TAGACCTGCTGGATGTATTTC	0.393			NA											40	19					8.01111e-26	1.57431e-25	0.002522	1	0
EGF	1950	broad.mit.edu	37	4	110883141	110883141	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:110883141G>C	uc003hzy.3	+	8	1764	c.1312G>C	c.(1312-1314)GGT>CGT	p.G438R	EGF_uc011cfu.1_Missense_Mutation_p.G396R|EGF_uc011cfv.1_Missense_Mutation_p.G438R	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	438	EGF-like 4.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AACATGTAGCGGTGAGTTTAT	0.378			NA											48	17					0	0	0.00361	0	0
SLC10A7	84068	broad.mit.edu	37	4	147438231	147438231	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:147438231C>A	uc010ioz.2	-	2	396	c.142G>T	c.(142-144)GCA>TCA	p.A48S	SLC10A7_uc003ikr.2_Missense_Mutation_p.A48S|SLC10A7_uc010ipa.2_Missense_Mutation_p.A48S|SLC10A7_uc003iks.2_RNA|SLC10A7_uc003ikt.2_Missense_Mutation_p.A48S|SLC10A7_uc003iku.3_RNA	NM_001029998	NP_001025169	Q0GE19	NTCP7_HUMAN	solute carrier family 10 (sodium/bile acid	48	Helical; (Potential).					integral to membrane	bile acid:sodium symporter activity				0	all_hematologic(180;0.151)					AATATTGTTGCAACAGCAATG	0.338			NA											73	40					3.30373e-36	6.94798e-36	0.00361	1	0
TLL1	7092	broad.mit.edu	37	4	166986864	166986864	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:166986864G>T	uc003irh.1	+	16	2684	c.2037G>T	c.(2035-2037)TGG>TGT	p.W679C	TLL1_uc011cjn.1_Missense_Mutation_p.W702C|TLL1_uc011cjo.1_Missense_Mutation_p.W503C	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	679	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGGAGATCTGGAGTGGTCTTT	0.373			NA											45	18					4.01344e-20	7.51736e-20	0.00361	1	0
ENPP6	133121	broad.mit.edu	37	4	185012394	185012394	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:185012394G>A	uc003iwc.2	-	8	1401	c.1259C>T	c.(1258-1260)ACT>ATT	p.T420I		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	420	Helical; (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		AGGCGGGGCAGTGCTGGCGCG	0.557			NA											5	22					0	0	0.001168	0	0
TRIML2	205860	broad.mit.edu	37	4	189012681	189012681	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:189012681G>T	uc003izl.2	-	7	1046	c.1010C>A	c.(1009-1011)ACC>AAC	p.T337N	TRIML2_uc003izj.1_Missense_Mutation_p.T165N|TRIML2_uc003izk.1_Missense_Mutation_p.T145N|TRIML2_uc011cle.1_Missense_Mutation_p.T412N	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	337	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GGACATCTCGGTCACATTGTA	0.493			NA											47	18					5.78141e-17	1.02864e-16	0.003214	1	0
TRIML1	339976	broad.mit.edu	37	4	189068142	189068142	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr4:189068142C>A	uc003izm.1	+	6	1138	c.1023C>A	c.(1021-1023)CAC>CAA	p.H341Q	TRIML1_uc003izn.1_Missense_Mutation_p.H65Q	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	341	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GTGGGAGACACTACTGGGAGG	0.562	Melanoma(31;213 1036 16579 23968 32372)		NA											22	13					5.26018e-13	8.5791e-13	0.001882	1	0
PLEKHG4B	153478	broad.mit.edu	37	5	163501	163501	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:163501G>A	uc003jak.2	+	11	2296	c.2246G>A	c.(2245-2247)AGT>AAT	p.S749N		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	749					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GACCATACTAGTGTCTTCAGC	0.567			NA											43	167					0	0	0.002852	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629486	9629486	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:9629486C>G	uc003jem.1	-	1	978	c.659G>C	c.(658-660)AGG>ACG	p.R220T		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	220	Cytoplasmic (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						GGGTGCACCCCTGCCAGGAAC	0.493			NA											19	60					0	0	0.007413	0	0
CTNND2	1501	broad.mit.edu	37	5	11023036	11023036	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:11023036G>C	uc003jfa.1	-	17	2989	c.2844C>G	c.(2842-2844)AAC>AAG	p.N948K	CTNND2_uc010itt.2_Missense_Mutation_p.N857K|CTNND2_uc011cmy.1_Missense_Mutation_p.N611K|CTNND2_uc011cmz.1_Missense_Mutation_p.N515K|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.N540K	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	948					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TTGCAGTGTTGTTGCTGTTGT	0.498			NA											13	89					0	0	0.00245	0	0
TRIO	7204	broad.mit.edu	37	5	14378120	14378120	+	Splice_Site	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:14378120G>T	uc003jff.2	+	20	3338	c.3332_splice	c.e20-1	p.N1111_splice	TRIO_uc003jfg.2_Splice_Site|TRIO_uc011cna.1_Splice_Site_p.N1062_splice|TRIO_uc003jfh.1_Splice_Site_p.N760_splice	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TTTTCTCTCAGATATCTTGAA	0.393			NA											10	26					3.86212e-05	5.12278e-05	0.008291	1	0
CDH18	1016	broad.mit.edu	37	5	19571701	19571701	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:19571701T>A	uc003jgc.2	-	7	1617	c.1240A>T	c.(1240-1242)AAC>TAC	p.N414Y	CDH18_uc003jgd.2_Missense_Mutation_p.N414Y|CDH18_uc011cnm.1_Missense_Mutation_p.N414Y	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	414	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ACTAAGCTGTTAGTACTGTCA	0.373			NA											58	97					0	0	0.00361	0	0
CDH12	1010	broad.mit.edu	37	5	21802377	21802377	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:21802377G>T	uc010iuc.2	-	7	1613	c.1155C>A	c.(1153-1155)AGC>AGA	p.S385R	CDH12_uc011cno.1_Missense_Mutation_p.S345R|CDH12_uc003jgk.2_Missense_Mutation_p.S385R	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	385	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						AGAGCGGCTTGCTGAAAACCG	0.547			NA								HNSCC(59;0.17)			12	45					1.61879e-10	2.51608e-10	0.001368	1	0
PRDM9	56979	broad.mit.edu	37	5	23526943	23526943	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:23526943C>T	uc003jgo.2	+	11	1928	c.1746C>T	c.(1744-1746)TGC>TGT	p.C582C		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	582	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CCTATGTCTGCAGGGAGTGTG	0.597			NA								HNSCC(3;0.000094)			32	133					0	0	0.00623	0	0
CDH9	1007	broad.mit.edu	37	5	26886084	26886084	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:26886084C>A	uc003jgs.1	-	10	1790	c.1621G>T	c.(1621-1623)GAT>TAT	p.D541Y	CDH9_uc011cnv.1_Missense_Mutation_p.D134Y	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	541	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CCTTTATTATCTACAATGGTG	0.303	Melanoma(8;187 585 15745 40864 52829)		NA											50	96					3.31993e-32	6.86166e-32	0.00361	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33577051	33577051	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:33577051G>C	uc003jia.1	-	19	3243	c.3080C>G	c.(3079-3081)TCC>TGC	p.S1027C	ADAMTS12_uc010iuq.1_Missense_Mutation_p.S942C	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1027	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTGGGCCTGGATGTAGGTGG	0.527			NA								HNSCC(64;0.19)			31	85					0	0	0.008361	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33649767	33649767	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:33649767C>A	uc003jia.1	-	8	1389	c.1226G>T	c.(1225-1227)TGT>TTT	p.C409F	ADAMTS12_uc010iuq.1_Missense_Mutation_p.C409F	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	409	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CACAGGCTCACAGTCATTTTC	0.542			NA								HNSCC(64;0.19)			19	63					2.27731e-05	3.04594e-05	0.001882	1	0
TTC23L	153657	broad.mit.edu	37	5	34845695	34845695	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:34845695A>T	uc003jiu.2	+	3	275	c.172A>T	c.(172-174)AAG>TAG	p.K58*		NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	58							binding			central_nervous_system(1)	1						AGAGAAGGAGAAGGCCATAGA	0.433			NA											15	62					0	0	0.00499	0	0
IL7R	3575	broad.mit.edu	37	5	35867563	35867563	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:35867563T>C	uc003jjs.2	+	3	466	c.377T>C	c.(376-378)ATA>ACA	p.I126T	IL7R_uc011coo.1_Missense_Mutation_p.I126T|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	126	Extracellular (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CTAACCACTATAGGTAAGAAG	0.353			NA											39	72					0	0	0.006999	0	0
NIPBL	25836	broad.mit.edu	37	5	37007478	37007478	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:37007478A>T	uc003jkl.3	+	18	4640	c.4141A>T	c.(4141-4143)AGA>TGA	p.R1381*	NIPBL_uc003jkk.3_Nonsense_Mutation_p.R1381*	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1381					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CCATAAGCAGAGAGTAATAGT	0.318			NA											17	47					0	0	0.00499	0	0
GDNF	2668	broad.mit.edu	37	5	37815911	37815911	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:37815911A>G	uc011cpi.1	-	3	678	c.478T>C	c.(478-480)TTG>CTG	p.L160L	GDNF_uc011cpc.1_Silent_p.L82L|GDNF_uc011cpd.1_Silent_p.L108L|GDNF_uc011cpe.1_Silent_p.L134L|GDNF_uc011cpf.1_Silent_p.L134L|GDNF_uc011cpg.1_Silent_p.L177L|GDNF_uc011cph.1_Silent_p.L151L	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	160					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					AAGTTTTTCAATATTTTGTCG	0.458			NA											52	135					0	0	0.00361	0	0
CARD6	84674	broad.mit.edu	37	5	40853641	40853641	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:40853641C>G	uc003jmg.2	+	3	2282	c.2207C>G	c.(2206-2208)ACC>AGC	p.T736S		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	736					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						CTCTTTCCAACCAGAATTGGA	0.502			NA											182	198					0	0	0.00361	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41018863	41018863	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:41018863G>T	uc003jmj.3	-	26	3093	c.2603C>A	c.(2602-2604)GCC>GAC	p.A868D	HEATR7B2_uc003jmi.3_Missense_Mutation_p.A423D	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	868							binding			ovary(6)|central_nervous_system(2)	8						TTTTCCTAGGGCGTCCATGGA	0.453			NA											19	89					1.33834e-09	2.0308e-09	0.007413	1	0
HCN1	348980	broad.mit.edu	37	5	45303797	45303797	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:45303797C>A	uc003jok.2	-	6	1547	c.1522G>T	c.(1522-1524)GTG>TTG	p.V508L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	508	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTTTTACCCACGGCTCCTTCT	0.393			NA											59	130					6.09941e-20	1.14022e-19	0.00361	1	0
SKIV2L2	23517	broad.mit.edu	37	5	54649077	54649077	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:54649077G>C	uc003jpy.3	+	14	1779	c.1513G>C	c.(1513-1515)GAT>CAT	p.D505H	SKIV2L2_uc011cqi.1_Missense_Mutation_p.D404H	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	505	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				CCGCAAATTTGATGGGAAGGA	0.338	Melanoma(2;92 134 23744 29976 33782)		NA											42	9					0	0	0.002852	0	0
FCHO2	115548	broad.mit.edu	37	5	72383470	72383470	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:72383470C>T	uc003kcl.2	+	25	2416	c.2300C>T	c.(2299-2301)ACG>ATG	p.T767M	FCHO2_uc011csl.1_Missense_Mutation_p.T734M|FCHO2_uc010izb.2_Missense_Mutation_p.T195M|FCHO2_uc011csn.1_Missense_Mutation_p.T195M	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	767										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		AGTAAACCCACGACACTTGCA	0.433			NA											7	37					0	0	0.001984	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101774337	101774337	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:101774337C>A	uc003knn.2	-	7	1432	c.1260G>T	c.(1258-1260)GTG>GTT	p.V420V	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Silent_p.V420V|SLCO6A1_uc003knq.2_Silent_p.V358V	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	420	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GTGTAGTTGCCACAGTGGGTG	0.294			NA											49	12					5.37117e-13	8.74526e-13	0.00361	1	0
CAMK4	814	broad.mit.edu	37	5	110730453	110730453	+	Silent	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:110730453C>G	uc011cvj.1	+	6	531	c.432C>G	c.(430-432)GCC>GCG	p.A144A	CAMK4_uc003kpf.2_Silent_p.A144A|CAMK4_uc010jbv.2_5'UTR	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	144	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		CTGCAGATGCCGTTAAACAAA	0.388			NA											24	33					0	0	0.002299	0	0
TRIM36	55521	broad.mit.edu	37	5	114480312	114480312	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:114480312C>A	uc003kqs.2	-	4	1263	c.754G>T	c.(754-756)GCC>TCC	p.A252S	TRIM36_uc011cwc.1_Missense_Mutation_p.A240S|TRIM36_uc003kqt.2_Missense_Mutation_p.A97S	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	252						acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GTTTTGTAGGCACTGCTCATA	0.368			NA											25	10					2.44723e-14	4.10296e-14	0.004656	1	0
FBN2	2201	broad.mit.edu	37	5	127614379	127614379	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:127614379G>T	uc003kuu.2	-	57	7732	c.7293C>A	c.(7291-7293)GCC>GCA	p.A2431A		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2431	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTTGTACTGGGCAGTTCCAG	0.458			NA											45	20					1.63429e-32	3.39975e-32	0.00361	1	0
CDC25C	995	broad.mit.edu	37	5	137665288	137665288	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:137665288C>A	uc003lcp.1	-	3	514	c.243G>T	c.(241-243)GAG>GAT	p.E81D	CDC25C_uc003lcq.1_Intron|CDC25C_uc003lcr.1_Missense_Mutation_p.E81D|CDC25C_uc011cyp.1_Missense_Mutation_p.E98D|CDC25C_uc003lcs.1_Missense_Mutation_p.E159D|CDC25C_uc010jet.1_Missense_Mutation_p.E81D|CDC25C_uc003lct.1_Missense_Mutation_p.E81D|CDC25C_uc003lcu.1_Intron	NM_001790	NP_001781	P30307	MPIP3_HUMAN	cell division cycle 25C isoform a	81					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			lung(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TGGCAGTTATCTCCCCACTGC	0.418			NA											70	22					2.18329e-32	4.52219e-32	0.00361	1	0
PCDHA1	56147	broad.mit.edu	37	5	140167441	140167441	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:140167441C>A	uc003lhb.2	+	1	1566	c.1566C>A	c.(1564-1566)CCC>CCA	p.P522P	PCDHA1_uc003lha.2_Silent_p.P522P|PCDHA1_uc003lgz.2_Silent_p.P522P	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	522	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTGCAGCCCCTGGACCACG	0.677			NA											88	22					3.07327e-39	6.5205e-39	0.00361	1	0
PCDHA6	56142	broad.mit.edu	37	5	140208979	140208979	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:140208979C>T	uc003lho.2	+	1	1330	c.1303C>T	c.(1303-1305)CTG>TTG	p.L435L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.L435L|PCDHA6_uc011dab.1_Silent_p.L435L	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	435	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCCTTCGCTGTGGGCCAC	0.612			NA											28	59					0	0	0.002836	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214890	140214890	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:140214890A>G	uc003lhq.2	+	1	922	c.922A>G	c.(922-924)ATG>GTG	p.M308V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.M308V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	308	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAGGACATATGGATTTTGA	0.448	NSCLC(160;258 2013 5070 22440 28951)		NA											5	27					0	0	0.001855	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250330	140250330	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:140250330G>T	uc003lia.2	+	1	2500	c.1642G>T	c.(1642-1644)GTG>TTG	p.V548L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.V548L	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	548	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCAGCAACGTGACGCTGCA	0.657			NA											70	31					1.356e-25	2.65389e-25	0.00361	1	0
PCDHB4	56131	broad.mit.edu	37	5	140501789	140501789	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:140501789A>T	uc003lip.1	+	1	209	c.209A>T	c.(208-210)GAC>GTC	p.D70V		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	70	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTGACGATGACAAGCAGCGT	0.567			NA											32	9					0	0	0.001786	0	0
DIAPH1	1729	broad.mit.edu	37	5	140953299	140953299	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:140953299G>A	uc003llb.3	-	16	2259	c.2118C>T	c.(2116-2118)CCC>CCT	p.P706P	DIAPH1_uc003llc.3_Silent_p.P697P|DIAPH1_uc010jgc.1_Silent_p.P145P	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	706	FH1.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCAGGCAAGGGAGGAGGTG	0.637			NA											3	2					0	0	0.000602	0	0
LARS	51520	broad.mit.edu	37	5	145531495	145531495	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:145531495T>C	uc003lnx.1	-	14	1593	c.1355A>G	c.(1354-1356)CAG>CGG	p.Q452R	LARS_uc011dbq.1_Missense_Mutation_p.Q406R|LARS_uc011dbr.1_Missense_Mutation_p.Q398R|LARS_uc011dbs.1_Missense_Mutation_p.Q425R	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	452	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	ATTCTGGCTCTGAATTTTCAA	0.363			NA											156	31					0	0	0.00361	0	0
SPINK6	404203	broad.mit.edu	37	5	147593482	147593482	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:147593482G>A	uc003lpa.2	+	3	347	c.91G>A	c.(91-93)GGT>AGT	p.G31S		NM_205841	NP_995313	Q6UWN8	ISK6_HUMAN	serine protease inhibitor, Kazal type 6	31	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTGACTGTGGTGAGTTCCA	0.463			NA											42	6					0	0	0.002522	0	0
GM2A	2760	broad.mit.edu	37	5	150632802	150632802	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:150632802C>T	uc003ltr.3	+	1	190	c.25C>T	c.(25-27)CTC>TTC	p.L9F	GM2A_uc011dcs.1_RNA|GM2A_uc011dcr.1_Missense_Mutation_p.L9F	NM_000405	NP_000396	P17900	SAP3_HUMAN	GM2 ganglioside activator precursor	9						lysosome|nucleolus	sphingolipid activator protein activity				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAGGCTCCCCTCCTGATCGC	0.592			NA											21	50					0	0	0.002299	0	0
EBF1	1879	broad.mit.edu	37	5	158250262	158250262	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:158250262C>A	uc010jip.2	-	8	1002	c.700G>T	c.(700-702)GTC>TTC	p.V234F	EBF1_uc011ddw.1_Missense_Mutation_p.V101F|EBF1_uc011ddx.1_Missense_Mutation_p.V234F|EBF1_uc003lxl.3_Missense_Mutation_p.V211F	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	234					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTATTATGGACAAACATGTTA	0.468			NA	T	HMGA2	lipoma								25	10					3.08376e-08	4.4876e-08	0.00333	1	0
GABRG2	2566	broad.mit.edu	37	5	161580279	161580279	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:161580279C>A	uc003lyz.3	+	9	1667	c.1309C>A	c.(1309-1311)CGC>AGC	p.R437S	GABRG2_uc010jjc.2_Missense_Mutation_p.R485S|GABRG2_uc003lyy.3_Missense_Mutation_p.R445S|GABRG2_uc011dej.1_Missense_Mutation_p.R342S	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	437	Cytoplasmic (Probable).|Interaction with GABARAP (Potential).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GATACATATCCGCATTGCCAA	0.498			NA											109	25					3.28517e-43	7.03232e-43	0.00361	1	0
HMMR	3161	broad.mit.edu	37	5	162917455	162917455	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:162917455A>G	uc003lzf.2	+	17	2201	c.2019A>G	c.(2017-2019)CAA>CAG	p.Q673Q	HMMR_uc003lzh.2_Silent_p.Q674Q|HMMR_uc003lzg.2_Silent_p.Q658Q|HMMR_uc011dem.1_Silent_p.Q587Q|uc003lzi.2_Intron	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	673						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		CAAAACTTCAAGAGGAATTGA	0.313			NA											4	105					0	0	0.000602	0	0
ODZ2	57451	broad.mit.edu	37	5	167674028	167674028	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:167674028A>T	uc010jjd.2	+	27	6057	c.6057A>T	c.(6055-6057)TTA>TTT	p.L2019F	ODZ2_uc003lzr.3_Missense_Mutation_p.L1789F|ODZ2_uc003lzt.3_Missense_Mutation_p.L1392F|ODZ2_uc010jje.2_Missense_Mutation_p.L1283F	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TCTCCAAGTTATCAGAGATTG	0.527			NA											16	57					0	0	0.008871	0	0
SLIT3	6586	broad.mit.edu	37	5	168233555	168233555	+	Silent	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:168233555G>C	uc003mab.2	-	9	1251	c.831C>G	c.(829-831)TCC>TCG	p.S277S	SLIT3_uc010jjg.2_Silent_p.S277S|SLIT3_uc010jji.2_Silent_p.S277S|SLIT3_uc003mac.1_Silent_p.S74S	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	277	LRRNT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGCAGGAGATGGAGTTGGCAT	0.587	Ovarian(29;311 847 10864 17279 24903)		NA											49	16					0	0	0.00361	0	0
RNF44	22838	broad.mit.edu	37	5	175956382	175956382	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:175956382C>T	uc003mek.1	-	10	1668	c.1143G>A	c.(1141-1143)GTG>GTA	p.V381V	RNF44_uc011dfo.1_Silent_p.V289V|RNF44_uc003mel.1_Silent_p.V70V	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	381	RING-type; atypical.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAAGCAGACCACACACCTGT	0.627			NA											25	10					0	0	0.00333	0	0
HIVEP1	3096	broad.mit.edu	37	6	12163750	12163750	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:12163750C>T	uc003nac.2	+	9	7392	c.7213C>T	c.(7213-7215)CAT>TAT	p.H2405Y	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2405					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TGGGGGGATCCATGTGGTACC	0.527			NA											133	15					0	0	0.00361	0	0
SLC44A4	80736	broad.mit.edu	37	6	31831479	31831479	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:31831479G>A	uc010jti.2	-	21	2124	c.2058C>T	c.(2056-2058)TAC>TAT	p.Y686Y	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	686	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	TCTTGGACATGTAGTAGGGCC	0.587			NA											15	2					0	0	0.00245	0	0
SNRPC	6631	broad.mit.edu	37	6	34730397	34730397	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:34730397G>T	uc003ojt.1	+	3	92	c.77G>T	c.(76-78)AGT>ATT	p.S26I		NM_003093	NP_003084	P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	26	Matrin-type.			CSG -> RSR (in Ref. 2; AAA36618).	spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1						ACACACTGCAGTGGAAGGAAA	0.343	NSCLC(131;576 1831 5287 11175 13324)		NA											7	50					0.000157383	0.000205348	0.00308	1	0
DNAH8	1769	broad.mit.edu	37	6	38810560	38810560	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:38810560C>A	uc003ooe.1	+	33	4675	c.4075C>A	c.(4075-4077)CAG>AAG	p.Q1359K		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGCCATGAAACAGAGACACTG	0.388			NA											81	23					1.52589e-26	3.05497e-26	0.00361	1	0
BAI3	577	broad.mit.edu	37	6	69349118	69349118	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:69349118G>C	uc003pev.3	+	3	999	c.551G>C	c.(550-552)GGG>GCG	p.G184A	BAI3_uc010kak.2_Missense_Mutation_p.G184A	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	184	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TCAGAAAATGGGAGAACAGAA	0.423			NA											19	34					0	0	0.006122	0	0
CD109	135228	broad.mit.edu	37	6	74497058	74497058	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:74497058G>T	uc003php.2	+	21	2864	c.2439G>T	c.(2437-2439)GAG>GAT	p.E813D	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.E813D|CD109_uc010kba.2_Missense_Mutation_p.E736D	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	813						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TTCCCAGTGAGGATGGGGCAA	0.443			NA											30	37					4.31634e-10	6.65493e-10	0.002445	1	0
ZNF292	23036	broad.mit.edu	37	6	87970160	87970160	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:87970160G>T	uc003plm.3	+	8	6854	c.6813G>T	c.(6811-6813)TCG>TCT	p.S2271S		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2271	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CAACCCGGTCGAATCTCCTCC	0.418			NA											14	27					6.72482e-11	1.05034e-10	0.003163	1	0
ORC3L	23595	broad.mit.edu	37	6	88344667	88344667	+	Silent	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:88344667A>T	uc003pmh.2	+	12	1334	c.1290A>T	c.(1288-1290)CCA>CCT	p.P430P	ORC3L_uc011dzl.1_Silent_p.P430P|ORC3L_uc011dzm.1_Silent_p.P430P|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Silent_p.P430P|ORC3L_uc003pmi.2_Silent_p.P392P|ORC3L_uc011dzo.1_Silent_p.P287P|ORC3L_uc011dzp.1_Silent_p.P287P	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	430					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		CCAAGTATCCACTAGGTCGAC	0.363			NA											21	62					0	0	0.00278	0	0
CNR1	1268	broad.mit.edu	37	6	88854203	88854203	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:88854203C>A	uc011dzq.1	-	2	4354	c.791G>T	c.(790-792)TGC>TTC	p.C264F	CNR1_uc010kbz.2_Missense_Mutation_p.C264F|CNR1_uc011dzr.1_Missense_Mutation_p.C264F|CNR1_uc011dzs.1_Missense_Mutation_p.C264F|CNR1_uc003pmq.3_Missense_Mutation_p.C264F|CNR1_uc011dzt.1_Missense_Mutation_p.C264F|CNR1_uc010kca.2_Missense_Mutation_p.C231F	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	264	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	AATGTCTGAGCAAACAGATTG	0.512			NA											14	31					1.5842e-08	2.31593e-08	0.001855	1	0
CNR1	1268	broad.mit.edu	37	6	88854814	88854814	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:88854814C>G	uc011dzq.1	-	2	3743	c.180G>C	c.(178-180)GAG>GAC	p.E60D	CNR1_uc010kbz.2_Missense_Mutation_p.E60D|CNR1_uc011dzr.1_Missense_Mutation_p.E60D|CNR1_uc011dzs.1_Missense_Mutation_p.E60D|CNR1_uc003pmq.3_Missense_Mutation_p.E60D|CNR1_uc011dzt.1_Missense_Mutation_p.E60D|CNR1_uc010kca.2_Missense_Mutation_p.E27D	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	60	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CAGTCATCTTCTCTTGGAAGG	0.463			NA											17	17					0	0	0.00499	0	0
C6orf168	84553	broad.mit.edu	37	6	99790813	99790813	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:99790813C>A	uc003ppj.3	-	2	646	c.363G>T	c.(361-363)AAG>AAT	p.K121N	C6orf168_uc003ppi.3_5'UTR	NM_032511	NP_115900	Q5TGI0	CF168_HUMAN	hypothetical protein LOC84553	121										ovary(2)|central_nervous_system(1)	3		all_cancers(76;1.63e-06)|Acute lymphoblastic leukemia(125;5.12e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00898)|Colorectal(196;0.0699)|Lung NSC(302;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.073)		AAGTTTCCATCTTTAAACAGA	0.353			NA											19	26					1.56452e-12	2.50899e-12	0.007413	1	0
SIM1	6492	broad.mit.edu	37	6	100838354	100838354	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:100838354T>A	uc003pqj.3	-	11	2391	c.2184A>T	c.(2182-2184)AGA>AGT	p.R728S	SIM1_uc010kcu.2_Missense_Mutation_p.R728S	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	728	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AGGAATAGTTTCTAATGGTTT	0.448			NA											54	63					0	0	0.00361	0	0
SLC22A16	85413	broad.mit.edu	37	6	110746181	110746181	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:110746181C>T	uc003puf.2	-	8	1696	c.1629G>A	c.(1627-1629)GAG>GAA	p.E543E	SLC22A16_uc003pue.2_Silent_p.E524E	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	543					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CATTCTCTGACTCCAGTTTTG	0.473			NA											35	68					0	0	0.003271	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135263559	135263559	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:135263559G>T	uc003qew.2	-	3	483	c.430C>A	c.(430-432)CCG>ACG	p.P144T	ALDH8A1_uc003qex.2_Missense_Mutation_p.P144T|ALDH8A1_uc010kgh.2_5'UTR|ALDH8A1_uc011ecx.1_Missense_Mutation_p.P144T	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	144					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		ACTCCCACCGGGGCCCGCACC	0.572			NA											24	23					2.39556e-15	4.11711e-15	0.00278	1	0
MAP3K5	4217	broad.mit.edu	37	6	136934306	136934306	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:136934306T>A	uc003qhc.2	-	17	2728	c.2367A>T	c.(2365-2367)GAA>GAT	p.E789D	MAP3K5_uc011edj.1_Missense_Mutation_p.E36D|MAP3K5_uc011edk.1_Missense_Mutation_p.E634D	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	789	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		ATTTTAATCCTTCCAGTATTT	0.383			NA											20	25					0	0	0.008871	0	0
UST	10090	broad.mit.edu	37	6	149340274	149340274	+	Splice_Site	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:149340274G>A	uc003qmg.2	+	6	978	c.682_splice	c.e6-1	p.D228_splice		NM_005715	NP_005706	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase						protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			ovary(2)	2		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		TTCTCTTCTAGGATATCAATG	0.403			NA											22	45					0	0	0.00333	0	0
ESR1	2099	broad.mit.edu	37	6	152419935	152419935	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:152419935T>A	uc003qom.3	+	10	1992	c.1622T>A	c.(1621-1623)CTG>CAG	p.L541Q	ESR1_uc010kin.2_Missense_Mutation_p.L541Q|ESR1_uc010kio.2_Missense_Mutation_p.L543Q|ESR1_uc010kip.2_Missense_Mutation_p.L540Q|ESR1_uc003qon.3_Missense_Mutation_p.L541Q|ESR1_uc003qoo.3_Missense_Mutation_p.L541Q|ESR1_uc010kiq.2_Missense_Mutation_p.L139Q|ESR1_uc010kir.2_Missense_Mutation_p.L280Q|ESR1_uc011eet.1_RNA|ESR1_uc011eeu.1_RNA|ESR1_uc011eev.1_Missense_Mutation_p.L126Q|ESR1_uc011eew.1_3'UTR|ESR1_uc011eex.1_Missense_Mutation_p.L216Q|ESR1_uc011eey.1_3'UTR	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	541	Steroid-binding.|Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	GACCTGCTGCTGGAGATGCTG	0.577			NA											19	21					0	0	0.001523	0	0
NOX3	50508	broad.mit.edu	37	6	155743903	155743903	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:155743903G>T	uc003qqm.2	-	10	1336	c.1233C>A	c.(1231-1233)GTC>GTA	p.V411V		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	411	Helical; (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CGAAGGGAGTGACTCCGATCC	0.522			NA											20	73					6.33239e-15	1.07482e-14	0.001523	1	0
NOX3	50508	broad.mit.edu	37	6	155750019	155750019	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:155750019G>T	uc003qqm.2	-	9	1157	c.1054C>A	c.(1054-1056)CAC>AAC	p.H352N		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	352	Extracellular (Potential).|FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GCCCGGATGTGCACGCTGAAA	0.637			NA											22	32					4.35082e-09	6.52963e-09	0.001523	1	0
INTS1	26173	broad.mit.edu	37	7	1539894	1539894	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:1539894C>A	uc003skn.2	-	4	559	c.458G>T	c.(457-459)CGC>CTC	p.R153L	INTS1_uc003skq.2_Missense_Mutation_p.R153L	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	153					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGGCTTGGCGCGGGTGACCTT	0.627			NA											4	5					1.23904e-05	1.6642e-05	0.000602	1	0
FOXK1	221937	broad.mit.edu	37	7	4798711	4798711	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:4798711G>T	uc003snc.1	+	6	1284	c.1274G>T	c.(1273-1275)GGG>GTG	p.G425V	FOXK1_uc003sna.1_Missense_Mutation_p.G262V	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	425					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		ACACACCCCGGGCTGATGTCC	0.667			NA											24	58					1.1804e-14	1.99647e-14	0.003954	1	0
TMEM195	392636	broad.mit.edu	37	7	15405794	15405794	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:15405794C>T	uc003stb.1	-	11	1298	c.1128G>A	c.(1126-1128)TTG>TTA	p.L376L		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	376	Helical; (Potential).				ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CAATGGAAGTCAAGGTCAGGA	0.383			NA											16	10					0	0	0.003163	0	0
ITGB8	3696	broad.mit.edu	37	7	20420288	20420288	+	Splice_Site	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:20420288G>T	uc003suu.2	+	5	1341	c.636_splice	c.e5-1	p.S212_splice	ITGB8_uc011jyh.1_Splice_Site_p.S77_splice|ITGB8_uc003sut.2_Splice_Site_p.S212_splice	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor						cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						TTCCCACACAGTGACTACAAT	0.383			NA											13	57					1.5842e-08	2.31593e-08	0.001855	1	0
BMPER	168667	broad.mit.edu	37	7	34182920	34182920	+	Silent	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:34182920C>G	uc011kap.1	+	14	1938	c.1824C>G	c.(1822-1824)GCC>GCG	p.A608A		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	608					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						ATACCCGGGCCTGCCAGAGAG	0.473			NA											11	60					0	0	0.008291	0	0
C7orf36	57002	broad.mit.edu	37	7	39611874	39611874	+	Splice_Site	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:39611874A>G	uc003thc.3	+	3	261	c.252_splice	c.e3-2	p.S84_splice		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002												0						ACTTTTGTTCAGTGCTTTGCT	0.308			NA											4	19					0	0	0.000248	0	0
HECW1	23072	broad.mit.edu	37	7	43519207	43519207	+	Splice_Site	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:43519207A>G	uc003tid.1	+	17	3705	c.3100_splice	c.e17-2	p.S1034_splice	HECW1_uc011kbi.1_Splice_Site_p.S1000_splice	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GTCTGTTCGCAGTCTTTTTTC	0.493			NA											48	20					0	0	0.00361	0	0
HECW1	23072	broad.mit.edu	37	7	43548674	43548674	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:43548674G>A	uc003tid.1	+	24	4578	c.3973G>A	c.(3973-3975)GTG>ATG	p.V1325M	HECW1_uc011kbi.1_Missense_Mutation_p.V1291M|uc003tig.1_RNA	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1325	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TACTTACACGGTGCAGATCAG	0.448			NA											59	11					0	0	0.00361	0	0
ABCA13	154664	broad.mit.edu	37	7	48316083	48316083	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:48316083C>A	uc003toq.2	+	17	6845	c.6820C>A	c.(6820-6822)CTT>ATT	p.L2274I	ABCA13_uc010kyr.2_Missense_Mutation_p.L1777I	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2274					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATTCTTCTCCCTTTTTCTAAA	0.343			NA											9	24					7.48243e-07	1.05369e-06	0.006214	1	0
COBL	23242	broad.mit.edu	37	7	51092955	51092955	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:51092955G>A	uc003tpr.3	-	12	3804	c.3619C>T	c.(3619-3621)CCC>TCC	p.P1207S	COBL_uc003tps.2_Intron|COBL_uc011kcl.1_Intron|COBL_uc003tpp.3_Missense_Mutation_p.P993S|COBL_uc003tpq.3_Intron|COBL_uc003tpo.3_Missense_Mutation_p.P749S	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	1207	Poly-Pro.									skin(3)|ovary(2)	5	Glioma(55;0.08)					GGTGGTGGGGGAATGGCTGGT	0.627	NSCLC(189;2119 2138 12223 30818 34679)		NA											6	18					0	0	0.001168	0	0
POM121L12	285877	broad.mit.edu	37	7	53103817	53103817	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:53103817G>T	uc003tpz.2	+	1	469	c.453G>T	c.(451-453)TGG>TGT	p.W151C		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	151											0						AGAGCCCCTGGAGATCCCCTG	0.582			NA											9	16					2.17888e-05	2.91836e-05	0.006214	1	0
FKBP9L	360132	broad.mit.edu	37	7	55755564	55755564	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:55755564A>T	uc010kzl.2	-	4	429	c.329T>A	c.(328-330)TTG>TAG	p.L110*	FKBP9L_uc010kzk.2_5'UTR|FKBP9L_uc003tqt.2_5'UTR|FKBP9L_uc011kcs.1_5'UTR	NR_003949				SubName: Full=cDNA, FLJ79189, highly similar to FK506-binding protein 9 (EC 5.2.1.8);												0						GTCCATCCCCAACACAACTTG	0.507			NA											21	62					0	0	0.001882	0	0
CD36	948	broad.mit.edu	37	7	80286010	80286010	+	Missense_Mutation	SNP	C	C	T	rs150037612	byFrequency	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:80286010C>T	uc003uhc.2	+	7	959	c.275C>T	c.(274-276)ACG>ATG	p.T92M	CD36_uc003uhd.3_Missense_Mutation_p.T92M|CD36_uc011kgv.1_Missense_Mutation_p.T16M|CD36_uc003uhe.3_Missense_Mutation_p.T92M|CD36_uc003uhf.3_Missense_Mutation_p.T92M|CD36_uc003uhg.3_Missense_Mutation_p.T92M|CD36_uc003uhh.3_Missense_Mutation_p.T92M	NM_001127444	NP_001120916	P16671	CD36_HUMAN	CD36 antigen	92	Extracellular (Potential).				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			ovary(1)	1						GGTCCTTATACGTACAGGTGA	0.388			NA											23	63					0	0	0.00278	0	0
HGF	3082	broad.mit.edu	37	7	81388012	81388012	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:81388012G>T	uc003uhl.2	-	3	528	c.363C>A	c.(361-363)AAC>AAA	p.N121K	HGF_uc003uhm.2_Missense_Mutation_p.N121K|HGF_uc003uhn.1_Missense_Mutation_p.N121K|HGF_uc003uho.1_Missense_Mutation_p.N121K|HGF_uc003uhp.2_Missense_Mutation_p.N121K	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	121	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						AGTTACCTTTGTTTTCATAGA	0.338			NA											37	34					1.90571e-15	3.29887e-15	0.004289	1	0
HGF	3082	broad.mit.edu	37	7	81392114	81392114	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:81392114G>T	uc003uhl.2	-	2	328	c.163C>A	c.(163-165)CCA>ACA	p.P55T	HGF_uc003uhm.2_Missense_Mutation_p.P55T|HGF_uc003uhn.1_Missense_Mutation_p.P55T|HGF_uc003uho.1_Missense_Mutation_p.P55T|HGF_uc003uhp.2_Missense_Mutation_p.P55T	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	55	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TTCAGTGCTGGATCTATTTTG	0.308			NA											19	42					2.4624e-09	3.72467e-09	0.008871	1	0
ZAN	7455	broad.mit.edu	37	7	100385716	100385716	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:100385716C>T	uc003uwj.2	+	39	7350	c.7185C>T	c.(7183-7185)GTC>GTT	p.V2395V	ZAN_uc003uwk.2_Silent_p.V2395V|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.V445V	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2395	VWFD 4.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTACCACCGTCTACGGCTATA	0.607			NA											49	5					0	0	0.00361	0	0
SPDYE6	729597	broad.mit.edu	37	7	101988908	101988908	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:101988908G>T	uc011kkp.1	-	6	1386	c.965C>A	c.(964-966)CCG>CAG	p.P322Q	SPDYE6_uc003uzb.2_Missense_Mutation_p.P178Q	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	322	Arg-rich.										0						CCTGGCCCTCGGGTTCGTGGA	0.572			NA											83	391					3.19434e-75	7.01001e-75	0.00361	1	0
SPDYE6	729597	broad.mit.edu	37	7	101988946	101988946	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:101988946G>A	uc011kkp.1	-	6	1348	c.927C>T	c.(925-927)CTC>CTT	p.L309L	SPDYE6_uc003uzb.2_Silent_p.L165L	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	309	Arg-rich.										0						GACGCTTACGGAGCAAGGGTA	0.572			NA											83	538					0	0	0.00361	0	0
C7orf60	154743	broad.mit.edu	37	7	112555399	112555399	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:112555399T>G	uc003vgo.1	-	2	391	c.264A>C	c.(262-264)AAA>AAC	p.K88N	C7orf60_uc011kms.1_Missense_Mutation_p.K114N	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	88										ovary(2)|skin(1)	3						CCTCACAAGTTTTTGCCCAAT	0.343			NA											81	11					0	0	0.00361	0	0
LRRC4	64101	broad.mit.edu	37	7	127670199	127670199	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:127670199G>T	uc003vmk.2	-	2	632	c.495C>A	c.(493-495)TAC>TAA	p.Y165*	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	165	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GGTTGAAGGCGTAAGAGGGGA	0.572			NA											96	11					8.98033e-41	1.90957e-40	0.00361	1	0
PLXNA4	91584	broad.mit.edu	37	7	131831332	131831332	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:131831332C>T	uc003vra.3	-	28	5221	c.4992G>A	c.(4990-4992)AAG>AAA	p.K1664K	PLXNA4_uc003vqz.3_5'Flank	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1664	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGTCCCCCTCCTTCTGGTCTC	0.582			NA											128	167					0	0	0.00361	0	0
STRA8	346673	broad.mit.edu	37	7	134931195	134931196	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:134931195_134931196TG>AT	uc011kpx.1	+	6	473_474	c.473_474TG>AT	c.(472-474)ATG>AAT	p.M158N		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	158					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						AAACAGACGATGGACCTTCTGA	0.594			NA											9	4					0	0	0.004672	0	0
DENND2A	27147	broad.mit.edu	37	7	140269479	140269479	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:140269479C>G	uc010lnj.2	-	5	1651	c.1506G>C	c.(1504-1506)AGG>AGC	p.R502S	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.R502S|DENND2A_uc003vvw.2_Missense_Mutation_p.R502S|DENND2A_uc003vvx.2_Missense_Mutation_p.R502S	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	502										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					ACTGGGACAGCCTCTTCACCC	0.537			NA											133	26					0	0	0.00361	0	0
TRYX3	136541	broad.mit.edu	37	7	141954941	141954941	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:141954941A>T	uc003vxb.2	-	3	690	c.370T>A	c.(370-372)TAC>AAC	p.Y124N	TRYX3_uc003vxc.3_Missense_Mutation_p.Y124N	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	124	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					ATAGTTTGGTAGGGCAGGTTG	0.403			NA											160	19					0	0	0.00361	0	0
KEL	3792	broad.mit.edu	37	7	142639611	142639611	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:142639611G>A	uc003wcb.2	-	18	2157	c.1947C>T	c.(1945-1947)TAC>TAT	p.Y649Y		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	649	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GCCTCTTGCTGTATGCCTGGG	0.587			NA											17	3					0	0	0.007413	0	0
OR2A25	392138	broad.mit.edu	37	7	143771704	143771704	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:143771704A>G	uc011ktx.1	+	1	392	c.392A>G	c.(391-393)TAT>TGT	p.Y131C		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					CCTCTCCGATATTCTACCATC	0.463			NA											145	23					0	0	0.00361	0	0
SSPO	23145	broad.mit.edu	37	7	149482053	149482053	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:149482053C>T	uc010lpk.2	+	20	2841	c.2841C>T	c.(2839-2841)TGC>TGT	p.C947C	SSPO_uc010lpl.1_Missense_Mutation_p.A283V	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	947					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATCACTCCTGCCCTGCAGGCA	0.622			NA											27	6					0	0	0.004656	0	0
KCNH2	3757	broad.mit.edu	37	7	150648710	150648710	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:150648710C>G	uc003wic.2	-	7	1784	c.1771G>C	c.(1771-1773)GAC>CAC	p.D591H	KCNH2_uc003wib.2_Missense_Mutation_p.D251H|KCNH2_uc011kux.1_Missense_Mutation_p.D495H|KCNH2_uc003wid.2_Missense_Mutation_p.D251H|KCNH2_uc003wie.2_Missense_Mutation_p.D591H	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	591	Extracellular (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CCTATCTGGTCGCCCAGGTTG	0.612	GBM(137;110 1844 13671 20123 45161)		NA											73	10					0	0	0.00361	0	0
MLL3	58508	broad.mit.edu	37	7	151947003	151947003	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:151947003G>A	uc003wla.2	-	13	1990	c.1771C>T	c.(1771-1773)CAT>TAT	p.H591Y		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	591					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCTGAGGGATGACTCTTCTGT	0.368	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								14	52					0	0	0.00245	0	0
RP1L1	94137	broad.mit.edu	37	8	10465352	10465352	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:10465352C>G	uc003wtc.2	-	4	6485	c.6256G>C	c.(6256-6258)GAT>CAT	p.D2086H		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2086					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCCTGGGCATCTACATCTTCT	0.632			NA											57	119					0	0	0.00361	0	0
RP1L1	94137	broad.mit.edu	37	8	10465782	10465782	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:10465782C>A	uc003wtc.2	-	4	6055	c.5826G>T	c.(5824-5826)GAG>GAT	p.E1942D		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1942					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCTCTTCTGCCTCTTGGGCCT	0.602			NA											79	85					1.91123e-38	4.04606e-38	0.00361	1	0
RP1L1	94137	broad.mit.edu	37	8	10467877	10467877	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:10467877T>A	uc003wtc.2	-	4	3960	c.3731A>T	c.(3730-3732)TAT>TTT	p.Y1244F		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1244					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGGGCTCTCATAAGTTCTTGA	0.562			NA											25	37					0	0	0.00333	0	0
RP1L1	94137	broad.mit.edu	37	8	10469061	10469061	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:10469061A>G	uc003wtc.2	-	4	2776	c.2547T>C	c.(2545-2547)TGT>TGC	p.C849C		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	849					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGTACCTGCCACACAGCCAGC	0.736			NA											5	2					0	0	0.000602	0	0
RP1L1	94137	broad.mit.edu	37	8	10469837	10469837	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:10469837C>A	uc003wtc.2	-	4	2000	c.1771G>T	c.(1771-1773)GCA>TCA	p.A591S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	591					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGCGTCTCTGCCTGCAGGTCG	0.642			NA											13	92					0.000151284	0.000197659	0.001855	1	0
XKR6	286046	broad.mit.edu	37	8	10755777	10755777	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:10755777C>A	uc003wtk.1	-	3	1638	c.1611G>T	c.(1609-1611)CGG>CGT	p.R537R		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	537						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CCTGGGTCCCCCGGTACCCAG	0.617			NA											11	15					0.000978159	0.00124741	0.000978	1	0
MTMR9	66036	broad.mit.edu	37	8	11174306	11174306	+	Missense_Mutation	SNP	G	G	T	rs149021500	byFrequency	TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:11174306G>T	uc003wtm.2	+	8	1636	c.1238G>T	c.(1237-1239)TGT>TTT	p.C413F	MTMR9_uc010lrx.2_Missense_Mutation_p.C306F|MTMR9_uc011kxa.1_Missense_Mutation_p.C328F|uc003wtn.1_RNA	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	413	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		CAGTTTCCCTGTTCTTTTGAG	0.448			NA											22	54					1.55795e-14	2.62118e-14	0.001882	1	0
FDFT1	2222	broad.mit.edu	37	8	11687842	11687842	+	Silent	SNP	C	C	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:11687842C>G	uc003wui.2	+	6	944	c.792C>G	c.(790-792)ACC>ACG	p.T264T	FDFT1_uc003wuh.2_Silent_p.T200T|FDFT1_uc010lsa.1_Silent_p.T179T|FDFT1_uc011kxe.1_Silent_p.T200T|FDFT1_uc011kxf.1_Silent_p.T221T|FDFT1_uc011kxg.1_Silent_p.T97T|FDFT1_uc003wuj.2_Silent_p.T257T|FDFT1_uc010lsb.2_Silent_p.T200T|FDFT1_uc011kxh.1_Silent_p.T200T|FDFT1_uc011kxi.1_Intron|FDFT1_uc011kxj.1_Silent_p.T200T|FDFT1_uc003wuk.2_Silent_p.T323T|FDFT1_uc011kxk.1_Silent_p.T179T	NM_004462	NP_004453	P37268	FDFT_HUMAN	squalene synthase	264					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity				0	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		AACTTATAACCAATGCACTGC	0.463			NA											29	62					0	0	0.001786	0	0
DLC1	10395	broad.mit.edu	37	8	12957737	12957737	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:12957737C>A	uc003wwm.2	-	9	2553	c.2109G>T	c.(2107-2109)ATG>ATT	p.M703I	DLC1_uc003wwk.1_Missense_Mutation_p.M266I|DLC1_uc003wwl.1_Missense_Mutation_p.M300I|DLC1_uc011kxx.1_Missense_Mutation_p.M192I	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	703					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCTCCTCATCCATCCCCTCTT	0.562			NA											22	32					1.87028e-06	2.59566e-06	0.001882	1	0
SLC7A2	6542	broad.mit.edu	37	8	17401089	17401089	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:17401089A>C	uc011kyc.1	+	2	410	c.241A>C	c.(241-243)ATG>CTG	p.M81L	SLC7A2_uc011kyd.1_Missense_Mutation_p.M121L|SLC7A2_uc011kye.1_Missense_Mutation_p.M121L|SLC7A2_uc011kyf.1_Missense_Mutation_p.M81L	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	81	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	GGCTTCAGTGATGGCTGGCCT	0.607			NA											12	26					0	0	0.000978	0	0
LPL	4023	broad.mit.edu	37	8	19813423	19813423	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:19813423G>A	uc003wzk.3	+	6	1217	c.847G>A	c.(847-849)GAA>AAA	p.E283K		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	283					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	GTTGAATGAAGAAAATCCAAG	0.468			NA											28	33					0	0	0.00632	0	0
UNC5D	137970	broad.mit.edu	37	8	35608159	35608159	+	Silent	SNP	G	G	C	rs145027081		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:35608159G>C	uc003xjr.1	+	13	2323	c.1995G>C	c.(1993-1995)GCG>GCC	p.A665A	UNC5D_uc003xjs.1_Silent_p.A660A|UNC5D_uc003xju.1_Silent_p.A241A	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	665	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ACCCCTTTGCGTGTCATGTGC	0.488			NA											31	67					0	0	0.002445	0	0
ANK1	286	broad.mit.edu	37	8	41546073	41546073	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:41546073G>T	uc003xok.2	-	34	4223	c.4139C>A	c.(4138-4140)ACG>AAG	p.T1380K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.T696K|ANK1_uc003xoi.2_Missense_Mutation_p.T1380K|ANK1_uc003xoj.2_Missense_Mutation_p.T1380K|ANK1_uc003xol.2_Missense_Mutation_p.T1380K|ANK1_uc003xom.2_Missense_Mutation_p.T1421K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1380					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGCCAGGGGCGTCGGGGTCCT	0.567			NA											21	45					2.39556e-15	4.11711e-15	0.00278	1	0
HGSNAT	138050	broad.mit.edu	37	8	43025733	43025733	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:43025733G>T	uc003xpx.3	+	7	687	c.639G>T	c.(637-639)CTG>CTT	p.L213L		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	241	Cytoplasmic (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TGAAGGAGCTGGGATCTCCCA	0.453			NA											12	14					2.27111e-07	3.25074e-07	0.001368	1	0
SNTG1	54212	broad.mit.edu	37	8	51617187	51617187	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:51617187C>A	uc010lxy.1	+	17	1437	c.1066C>A	c.(1066-1068)CAG>AAG	p.Q356K	SNTG1_uc003xqs.1_Missense_Mutation_p.Q356K|SNTG1_uc010lxz.1_Missense_Mutation_p.Q356K|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	356	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CCGACGGAAACAGTGCTTCAC	0.552			NA											93	99					6.84326e-50	1.48142e-49	0.00361	1	0
SNTG1	54212	broad.mit.edu	37	8	51705364	51705364	+	Missense_Mutation	SNP	C	C	A	rs149567485		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:51705364C>A	uc010lxy.1	+	20	1900	c.1529C>A	c.(1528-1530)ACG>AAG	p.T510K	SNTG1_uc003xqs.1_Missense_Mutation_p.T510K|SNTG1_uc010lxz.1_Missense_Mutation_p.T473K|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	510					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCTGCTACCACGAGCAAAGCA	0.433			NA											84	116					1.17611e-34	2.45728e-34	0.00361	1	0
PXDNL	137902	broad.mit.edu	37	8	52366215	52366215	+	Silent	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:52366215C>A	uc003xqu.3	-	10	1214	c.1113G>T	c.(1111-1113)CTG>CTT	p.L371L		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	371	Ig-like C2-type 2.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGGATCCATCCAGCTCCAATC	0.502			NA											59	46					5.82218e-30	1.19305e-29	0.00361	1	0
CHD7	55636	broad.mit.edu	37	8	61754571	61754571	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:61754571A>T	uc003xue.2	+	21	5287	c.4810A>T	c.(4810-4812)AGT>TGT	p.S1604C		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1604					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTATGCAAGGAGTGAATGTTT	0.443			NA											7	51					0	0	0.004482	0	0
GGH	8836	broad.mit.edu	37	8	63951236	63951236	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:63951236G>A	uc003xuw.2	-	1	375	c.92C>T	c.(91-93)GCC>GTC	p.A31V		NM_003878	NP_003869	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase precursor	31	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity				0	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	GGGCTTCTTGGCGGTGTCGCC	0.726			NA											7	13					0	0	0.006214	0	0
CSPP1	79848	broad.mit.edu	37	8	68044212	68044212	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:68044212A>G	uc003xxi.2	+	16	1845	c.1814A>G	c.(1813-1815)AAG>AGG	p.K605R	CSPP1_uc003xxg.1_Missense_Mutation_p.K597R|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.K570R|CSPP1_uc003xxk.2_Missense_Mutation_p.K276R	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	605						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AATGAACTGAAGATTACAAGT	0.338			NA											49	110					0	0	0.00361	0	0
XKR9	389668	broad.mit.edu	37	8	71593465	71593465	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:71593465T>A	uc003xyq.2	+	3	706	c.172T>A	c.(172-174)TTT>ATT	p.F58I	XKR9_uc010lze.2_Missense_Mutation_p.F58I|XKR9_uc010lzd.2_5'UTR	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	58	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			GGCTCAGTGTTTTAGTTATTC	0.378			NA											36	657					0	0	0.003755	0	0
RDH10	157506	broad.mit.edu	37	8	74235015	74235015	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:74235015G>T	uc003xzi.2	+	5	1132	c.872G>T	c.(871-873)CGC>CTC	p.R291L	RDH10_uc003xzj.2_Missense_Mutation_p.R126L|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	291					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			TGCACTCCCCGCCTCATGTAC	0.512			NA											69	68					4.83874e-46	1.04044e-45	0.00361	1	0
JPH1	56704	broad.mit.edu	37	8	75227360	75227360	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:75227360C>A	uc003yae.2	-	2	915	c.875G>T	c.(874-876)GGC>GTC	p.G292V	JPH1_uc003yaf.2_Missense_Mutation_p.G292V|JPH1_uc003yag.1_Missense_Mutation_p.G156V	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	292	Cytoplasmic (Potential).|MORN 6.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			AACGCCGAAGCCGTTGCGCTT	0.547			NA											105	108					5.74361e-68	1.2547e-67	0.00361	1	0
CA1	759	broad.mit.edu	37	8	86240798	86240798	+	Silent	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:86240798A>T	uc003ydh.2	-	9	977	c.777T>A	c.(775-777)GCT>GCA	p.A259A	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Silent_p.A259A|CA1_uc003ydi.2_Silent_p.A259A	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	259					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	ATCAAAATGAAGCTCTCACTG	0.403			NA											15	128					0	0	0.00499	0	0
SLC26A7	115111	broad.mit.edu	37	8	92261894	92261894	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:92261894G>A	uc003yex.2	+	3	293	c.15G>A	c.(13-15)AAG>AAA	p.K5K	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Silent_p.K5K|SLC26A7_uc003yfa.2_Silent_p.K5K	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	5	Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CAGGAGCAAAGAGGAAAAAGA	0.413			NA											45	61					0	0	0.00361	0	0
RBM12B	389677	broad.mit.edu	37	8	94747176	94747176	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:94747176G>A	uc003yfz.2	-	3	1656	c.1463C>T	c.(1462-1464)TCT>TTT	p.S488F		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	488							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGACATCACAGAAAAATTTAC	0.408			NA											16	280					0	0	0.00499	0	0
RRM2B	50484	broad.mit.edu	37	8	103244533	103244533	+	Splice_Site	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:103244533C>T	uc003ykn.2	-	2	293	c.49_splice	c.e2-1	p.R17_splice	RRM2B_uc003yko.2_Splice_Site|RRM2B_uc010mbv.1_Intron|RRM2B_uc010mbw.1_Intron|RRM2B_uc010mbx.1_Splice_Site|RRM2B_uc010mby.1_Intron	NM_015713	NP_056528	Q7LG56	RIR2B_HUMAN	ribonucleotide reductase M2 B (TP53 inducible)						deoxyribonucleoside diphosphate metabolic process|DNA repair|nucleobase, nucleoside and nucleotide interconversion	nucleoplasm	ribonucleoside-diphosphate reductase activity|transition metal ion binding			ovary(2)	2	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000728)			AAGATGATCTCTTTGAAAAAT	0.353			NA						Direct_reversal_of_damage|Modulation_of_nucleotide_pools					55	48					0	0	0.00361	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815123	106815123	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:106815123C>A	uc003ymd.2	+	8	2836	c.2813C>A	c.(2812-2814)ACC>AAC	p.T938N	ZFPM2_uc011lhs.1_Missense_Mutation_p.T669N	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	938					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CACCTAGCAACCCTGCAAGGC	0.423			NA											13	20					2.61681e-11	4.12751e-11	0.00245	1	0
CSMD3	114788	broad.mit.edu	37	8	113960063	113960063	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:113960063A>T	uc003ynu.2	-	9	1623	c.1464T>A	c.(1462-1464)GAT>GAA	p.D488E	CSMD3_uc003ynt.2_Missense_Mutation_p.D448E|CSMD3_uc011lhx.1_Missense_Mutation_p.D384E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	488	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTTCTCCTGGATCTGGGCATA	0.303			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	62					0	0	0.006214	0	0
COL14A1	7373	broad.mit.edu	37	8	121344966	121344966	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:121344966G>C	uc003yox.2	+	42	5042	c.4777G>C	c.(4777-4779)GGA>CGA	p.G1593R	COL14A1_uc003yoz.2_Missense_Mutation_p.G558R	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1593	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGGCGCCCTGGGACCACCTGT	0.502			NA											10	32					0	0	0.000978	0	0
GSDMC	56169	broad.mit.edu	37	8	130760847	130760847	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:130760847T>A	uc003ysr.2	-	14	2309	c.1427A>T	c.(1426-1428)GAG>GTG	p.E476V		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	476						mitochondrion				ovary(2)|skin(1)	3						GTTATCCAGCTCCATCCTAAG	0.577			NA											13	84					0	0	0.00245	0	0
FLJ43860	389690	broad.mit.edu	37	8	142450389	142450389	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:142450389G>T	uc003ywi.2	-	26	3240	c.3159C>A	c.(3157-3159)CCC>CCA	p.P1053P	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	1053							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCTCAGGGCTGGGGTCGTGGA	0.627			NA											5	7					0.000602214	0.000770031	0.000602	1	0
CYP11B2	1585	broad.mit.edu	37	8	143994079	143994079	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:143994079C>A	uc003yxk.1	-	8	1268	c.1265G>T	c.(1264-1266)CGG>CTG	p.R422L		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	422					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGGATTATACCGCTCAGGCCT	0.622			NA							Familial_Hyperaldosteronism_type_I				61	50					7.41606e-26	1.47552e-25	0.00361	1	0
ZNF623	9831	broad.mit.edu	37	8	144733608	144733608	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:144733608G>T	uc003yzd.2	+	1	1655	c.1566G>T	c.(1564-1566)TTG>TTT	p.L522F	ZNF623_uc011lkp.1_Missense_Mutation_p.L482F|ZNF623_uc003yzc.2_Missense_Mutation_p.L482F	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	522					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCATACATTTGGGTGAGAGGT	0.413			NA											38	68					9.80977e-26	1.92384e-25	0.004289	1	0
MAF1	84232	broad.mit.edu	37	8	145161324	145161324	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:145161324G>T	uc003zbc.1	+	5	958	c.457G>T	c.(457-459)GCG>TCG	p.A153S	SHARPIN_uc003zba.2_5'Flank|SHARPIN_uc003zbb.2_5'Flank|KIAA1875_uc003zbd.3_5'Flank|KIAA1875_uc011lky.1_5'Flank	NM_032272	NP_115648	Q9H063	MAF1_HUMAN	MAF1 protein	153					negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	cytoplasm|nucleus					0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.1e-42)|Epithelial(56;1.23e-40)|all cancers(56;4.84e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTGTGGAACGCGGTGGACGA	0.592			NA											20	30					1.15919e-05	1.56352e-05	0.008871	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777002	18777002	+	Silent	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:18777002G>T	uc003zne.3	+	19	2902	c.2775G>T	c.(2773-2775)ACG>ACT	p.T925T		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	925	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCACGTCACGGTGGCCCCCT	0.672			NA											18	63					1.99824e-07	2.86873e-07	0.00499	1	0
TAF1L	138474	broad.mit.edu	37	9	32635372	32635372	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:32635372C>A	uc003zrg.1	-	1	296	c.206G>T	c.(205-207)GGG>GTG	p.G69V	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	69					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCCCAAAGCCCCCAAGCCTGC	0.537			NA											16	51					3.52763e-06	4.83286e-06	0.00499	1	0
CCL21	6366	broad.mit.edu	37	9	34709603	34709603	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:34709603G>T	uc003zvo.2	-	3	349	c.265C>A	c.(265-267)CAT>AAT	p.H89N		NM_002989	NP_002980	O00585	CCL21_HUMAN	small inducible cytokine A21 precursor	89					activation of Rho GTPase activity|cell maturation|cell-cell signaling|dendritic cell chemotaxis|dendritic cell dendrite assembly|establishment of T cell polarity|immune response|immunological synapse formation|inflammatory response|mesangial cell-matrix adhesion|negative regulation of leukocyte apoptosis|positive regulation of actin filament polymerization|positive regulation of cell adhesion mediated by integrin|positive regulation of cell-matrix adhesion|positive regulation of dendritic cell antigen processing and presentation|positive regulation of ERK1 and ERK2 cascade|positive regulation of filopodium assembly|positive regulation of glycoprotein biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of myeloid dendritic cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of pseudopodium assembly|positive regulation of receptor-mediated endocytosis|release of sequestered calcium ion into cytosol|response to prostaglandin E stimulus|ruffle organization|T cell costimulation	extracellular space	CCR7 chemokine receptor binding|chemokine activity				0	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		TTGTCCAGATGCTGCATCAGC	0.607			NA											34	32					1.99505e-19	3.68643e-19	0.002445	1	0
C9orf131	138724	broad.mit.edu	37	9	35043482	35043482	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:35043482C>A	uc003zvw.2	+	2	885	c.856C>A	c.(856-858)CTC>ATC	p.L286I	C9orf131_uc003zvu.2_Missense_Mutation_p.L238I|C9orf131_uc003zvv.2_Missense_Mutation_p.L213I|C9orf131_uc003zvx.2_Missense_Mutation_p.L251I	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	286											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			ATCACTACTCCTCCATCTGAG	0.567			NA											62	45					9.59835e-30	1.95431e-29	0.00361	1	0
FLJ43950	347127	broad.mit.edu	37	9	84530665	84530665	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:84530665C>A	uc011lst.1	+	4	687	c.586C>A	c.(586-588)CTG>ATG	p.L196M		NR_026851				SubName: Full=cDNA FLJ43950 fis, clone TESTI4015293, moderately similar to FAM75-like protein;												0						GAGGGACCCTCTGCCACCACA	0.542			NA											131	26					5.21138e-58	1.13584e-57	0.00361	1	0
RASEF	158158	broad.mit.edu	37	9	85615133	85615133	+	Silent	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:85615133G>A	uc004amo.1	-	12	1935	c.1674C>T	c.(1672-1674)CTC>CTT	p.L558L		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	558					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						AAAGTCTCATGAGGAAACTAG	0.443			NA											60	5					0	0	0.00361	0	0
ZNF510	22869	broad.mit.edu	37	9	99521621	99521621	+	Silent	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:99521621A>G	uc004awn.1	-	6	1680	c.1491T>C	c.(1489-1491)TTT>TTC	p.F497F	ZNF510_uc004awo.1_Silent_p.F497F	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	497	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				ACTTCTGAACAAAAGTTTTCC	0.408			NA											131	16					0	0	0.00361	0	0
MRPL50	54534	broad.mit.edu	37	9	104152812	104152812	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:104152812G>A	uc004bbe.2	-	2	458	c.413C>T	c.(412-414)TCT>TTT	p.S138F	MRPL50_uc011lvj.1_Intron	NM_019051	NP_061924	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	138						mitochondrion|ribosome					0		Acute lymphoblastic leukemia(62;0.0559)				ATCAAATTTAGATCTATCTTG	0.408			NA											86	16					0	0	0.00361	0	0
DFNB31	25861	broad.mit.edu	37	9	117240967	117240967	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:117240967T>A	uc004biz.3	-	2	1352	c.703A>T	c.(703-705)ACC>TCC	p.T235S	DFNB31_uc004biy.3_5'UTR|DFNB31_uc004bja.3_Missense_Mutation_p.T235S|DFNB31_uc004bjb.2_Missense_Mutation_p.T235S	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	235					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TCCACCCAGGTGTAGATGTGG	0.667			NA											16	2					0	0	0.004007	0	0
PAPPA	5069	broad.mit.edu	37	9	118949571	118949571	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:118949571T>C	uc004bjn.2	+	2	935	c.554T>C	c.(553-555)ATC>ACC	p.I185T	PAPPA_uc011lxp.1_5'UTR|PAPPA_uc011lxq.1_5'UTR	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	185					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GTGACCACCATCAATGCCCAC	0.557			NA											18	74					0	0	0.00278	0	0
NCS1	23413	broad.mit.edu	37	9	132988695	132988695	+	Nonsense_Mutation	SNP	G	G	T	rs11440892		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:132988695G>T	uc004bzi.2	+	7	588	c.502G>T	c.(502-504)GAG>TAG	p.E168*	NCS1_uc010myz.1_Nonsense_Mutation_p.E150*	NM_014286	NP_055101	P62166	NCS1_HUMAN	frequenin homolog isoform 1	168	3.|EF-hand 4.				negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding				0						GACCCTGCAGGAGTTCCAGGA	0.647	Melanoma(30;182 1162 22581 33240)		NA											12	24					1.3612e-06	1.90014e-06	0.003163	1	0
BAT2L1	84726	broad.mit.edu	37	9	134354714	134354714	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:134354714G>T	uc004can.3	+	18	4889	c.4834G>T	c.(4834-4836)GAG>TAG	p.E1612*	BAT2L1_uc004cao.3_Nonsense_Mutation_p.E970*	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1612							protein binding				0						CTTATGTCTGGAGCAAGGTGA	0.572			NA											13	10					1.5842e-08	2.31593e-08	0.001855	1	0
COL5A1	1289	broad.mit.edu	37	9	137701111	137701111	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:137701111G>A	uc004cfe.2	+	43	3831	c.3449G>A	c.(3448-3450)GGT>GAT	p.G1150D		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1150	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGCCCTGTGGGTCCCCCTGGA	0.622			NA											5	17					0	0	0.000602	0	0
LCN8	138307	broad.mit.edu	37	9	139650984	139650984	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:139650984G>T	uc004cjb.1	-	3	565	c.216C>A	c.(214-216)TTC>TTA	p.F72L	LCN8_uc004cja.2_5'Flank|LCN8_uc004cjc.1_Missense_Mutation_p.F72L	NM_178469	NP_848564	Q6JVE9	LCN8_HUMAN	lipocalin 8	95					transport	extracellular region	binding			pancreas(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;5.56e-06)|Epithelial(140;8.32e-05)		CAGGAAAAGCGAATTTTCCCG	0.468			NA											62	80					1.02487e-32	2.13663e-32	0.00361	1	0
ZBED1	9189	broad.mit.edu	37	X	2406920	2406920	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:2406920G>A	uc004cqg.2	-	2	2042	c.1841C>T	c.(1840-1842)ACG>ATG	p.T614M	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.T614M	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	614						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCGACGCGCGTGGCCGTCAC	0.667			NA											46	71					0	0	0.003214	0	0
MXRA5	25878	broad.mit.edu	37	X	3239833	3239833	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:3239833G>T	uc004crg.3	-	5	4050	c.3893C>A	c.(3892-3894)ACC>AAC	p.T1298N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1298						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTTTCTGGTGGTTGTCATGTA	0.373			NA											76	14					3.33186e-49	7.19651e-49	0.00361	1	0
FRMPD4	9758	broad.mit.edu	37	X	12516865	12516865	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:12516865C>T	uc004cuz.1	+	2	614	c.108C>T	c.(106-108)CCC>CCT	p.P36P	FRMPD4_uc011mij.1_Silent_p.P28P	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	36	WW.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AGGTGCCGCCCTATGGATGGG	0.512			NA											22	1					0	0	0.003954	0	0
TLR8	51311	broad.mit.edu	37	X	12938504	12938504	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:12938504C>A	uc004cve.2	+	2	1413	c.1345C>A	c.(1345-1347)CGT>AGT	p.R449S	TLR8_uc004cvd.2_Missense_Mutation_p.R467S	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	449	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CTCTTTTCAACGTCATATCCG	0.378			NA											63	9					8.52622e-23	1.63533e-22	0.00361	1	0
MAGEB2	4113	broad.mit.edu	37	X	30237129	30237129	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:30237129G>T	uc004dbz.2	+	2	535	c.432G>T	c.(430-432)AGG>AGT	p.R144S		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	144	MAGE.						protein binding			ovary(1)	1						TTGGCAAAAGGTTCAGGGAGC	0.458			NA											7	8					0.00198382	0.00250656	0.001984	1	0
FTHL17	53940	broad.mit.edu	37	X	31089890	31089890	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:31089890C>A	uc004dcl.1	-	1	284	c.181G>T	c.(181-183)GAC>TAC	p.D61Y		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	61	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						ATTTTGTCGTCCGACAGGCGC	0.577			NA											29	30					6.04164e-23	1.16111e-22	0.002096	1	0
FAM47A	158724	broad.mit.edu	37	X	34149868	34149869	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:34149868_34149869GG>AT	uc004ddg.2	-	1	560_561	c.527_528CC>AT	c.(526-528)CCC>CAT	p.P176H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	176	Pro-rich.									ovary(4)|central_nervous_system(1)	5						CAGGCTCAGTGGGTACCTCTGT	0.584			NA											34	6					0	0	0.004672	0	0
DUSP21	63904	broad.mit.edu	37	X	44703516	44703516	+	Silent	SNP	T	T	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:44703516T>C	uc004dgd.2	+	1	268	c.138T>C	c.(136-138)AAT>AAC	p.N46N		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	46	Tyrosine-protein phosphatase.|Sufficient for mitochondrial localization (By similarity).					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						TGTCCAGCAATCGCATCACCG	0.522			NA											49	18					0	0	0.00361	0	0
KDM6A	7403	broad.mit.edu	37	X	44966737	44966737	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:44966737G>T	uc004dge.3	+	27	4336	c.3961G>T	c.(3961-3963)GGG>TGG	p.G1321W	KDM6A_uc011mkz.1_Missense_Mutation_p.G1373W|KDM6A_uc011mla.1_Missense_Mutation_p.G1276W|KDM6A_uc011mlb.1_Missense_Mutation_p.G1328W|KDM6A_uc011mlc.1_Missense_Mutation_p.G1025W|KDM6A_uc011mld.1_Missense_Mutation_p.G960W	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1321					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TATATGGCATGGGCGGACAAA	0.403	Colon(129;1273 1667 15230 27352 52914)		NA	D|N|F|S		renal|oesophageal SCC|MM								44	6					8.01111e-26	1.57431e-25	0.002522	1	0
HEPH	9843	broad.mit.edu	37	X	65479949	65479949	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:65479949A>G	uc011moz.1	+	19	3113	c.3053A>G	c.(3052-3054)GAG>GGG	p.E1018G	HEPH_uc004dwn.2_Missense_Mutation_p.E1018G|HEPH_uc004dwo.2_Missense_Mutation_p.E748G|HEPH_uc010nkr.2_Missense_Mutation_p.E826G|HEPH_uc011mpa.1_Missense_Mutation_p.E1018G	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1015	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						CAGAATGGCGAGAACTACCGG	0.488			NA											6	37					0	0	0.00308	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913898	77913898	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:77913898G>T	uc004edc.1	-	2	316	c.20C>A	c.(19-21)GCC>GAC	p.A7D		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	7							nucleic acid binding|zinc ion binding			ovary(1)	1						AATATAGGAGGCTGCTAAGTC	0.463			NA											7	4					2.0095e-06	2.76883e-06	0.001984	1	0
POF1B	79983	broad.mit.edu	37	X	84634369	84634369	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:84634369G>T	uc004eer.2	-	2	237	c.91C>A	c.(91-93)CAC>AAC	p.H31N	POF1B_uc004ees.2_Missense_Mutation_p.H31N	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	31							actin binding				0						TGGTAGCAGTGGTAATGCTGG	0.557			NA											3	3					6.4e-05	8.45586e-05	0.004672	1	0
RNF128	79589	broad.mit.edu	37	X	106033448	106033448	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:106033448G>T	uc004eml.2	+	5	1170	c.920G>T	c.(919-921)TGG>TTG	p.W307L	RNF128_uc004emk.2_Missense_Mutation_p.W281L	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	307	RING-type; atypical.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTTGACCCATGGCTGTTAGAA	0.318			NA											40	16					2.43277e-16	4.25735e-16	0.00361	1	0
TRPC5	7224	broad.mit.edu	37	X	111090519	111090519	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:111090519A>G	uc004epl.1	-	6	2442	c.1523T>C	c.(1522-1524)ATC>ACC	p.I508T	TRPC5_uc004epm.1_Missense_Mutation_p.I508T	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	508	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						TCCCAAAGAGATCTGCAGAGG	0.448			NA											37	7					0	0	0.00623	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685292	125685292	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:125685292G>T	uc004eul.2	-	1	1551	c.1300C>A	c.(1300-1302)CAC>AAC	p.H434N		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	434										skin(3)|ovary(1)	4						TTGTAGCAGTGGGTGTAGAGC	0.557			NA											56	19					3.40343e-31	7.01911e-31	0.00361	1	0
SAGE1	55511	broad.mit.edu	37	X	134994064	134994064	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:134994064G>T	uc004ezh.2	+	18	2640	c.2473G>T	c.(2473-2475)GAT>TAT	p.D825Y	SAGE1_uc010nry.1_Missense_Mutation_p.D794Y|SAGE1_uc011mvv.1_Missense_Mutation_p.D449Y	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	825										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GAAAATTAATGATGATATAAA	0.378			NA											12	5					0.00010058	0.000131951	0.001368	1	0
MAGEC3	139081	broad.mit.edu	37	X	140969201	140969201	+	Silent	SNP	C	C	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:140969201C>T	uc011mwp.1	+	4	528	c.528C>T	c.(526-528)AGC>AGT	p.S176S		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	176										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCAGAGAGCGAGCCCTTGT	0.473			NA											35	10					0	0	0.003755	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993867	140993867	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:140993867A>T	uc004fbt.2	+	4	963	c.677A>T	c.(676-678)GAG>GTG	p.E226V	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	226							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTACTTTTGAGGGTTTTGCC	0.493			NA								HNSCC(15;0.026)			40	26					0	0	0.00874	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994077	140994077	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:140994077A>T	uc004fbt.2	+	4	1173	c.887A>T	c.(886-888)GAG>GTG	p.E296V	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	296							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTACTTTTGAGGGTTTTCCC	0.498			NA								HNSCC(15;0.026)			26	26					0	0	0.008361	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904472	144904472	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:144904472G>T	uc004fcd.2	+	5	1519	c.529G>T	c.(529-531)GTG>TTG	p.V177L	SLITRK2_uc010nsp.2_Missense_Mutation_p.V177L|SLITRK2_uc010nso.2_Missense_Mutation_p.V177L|SLITRK2_uc011mwq.1_Missense_Mutation_p.V177L|SLITRK2_uc011mwr.1_Missense_Mutation_p.V177L|SLITRK2_uc011mws.1_Missense_Mutation_p.V177L|SLITRK2_uc004fcg.2_Missense_Mutation_p.V177L|SLITRK2_uc011mwt.1_Missense_Mutation_p.V177L	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	177	Extracellular (Potential).|LRR 5.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GCCCAGCAATGTGTTCCGCTT	0.483			NA											31	9					2.80507e-11	4.41718e-11	0.002445	1	0
MAGEA11	4110	broad.mit.edu	37	X	148796170	148796170	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chrX:148796170C>A	uc004fdq.2	+	3	228	c.126C>A	c.(124-126)TTC>TTA	p.F42L	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.F13L	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	42						cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					AGGACGACTTCCAGTCAACAG	0.542			NA											8	4					4.84862e-15	8.25901e-15	0.000978	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37430891	37430891	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr10:37430891delG	uc001iza.1	+	7	997	c.898delG	c.(898-900)GAAfs	p.E300fs		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	356						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GTCAGCAGAAGAAACACCTAG	0.433			NA											18	81	---	---	---	---	NA	NA	NA	NA	NA
AKAP3	10566	broad.mit.edu	37	12	4736719	4736719	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:4736719delC	uc001qnb.3	-	4	1578	c.1349delG	c.(1348-1350)GGTfs	p.G450fs		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	450					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						AATGTGCTCACCCAGAGTTTT	0.408			NA											67	24	---	---	---	---	NA	NA	NA	NA	NA
CDKN1B	1027	broad.mit.edu	37	12	12871130	12871131	+	Frame_Shift_Ins	INS	-	-	G			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr12:12871130_12871131insG	uc001rat.2	+	1	829_830	c.357_358insG	c.(355-360)ATTGGGfs	p.I119fs		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	119_120					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CGCCTTTAATTGGGGCTCCGGC	0.629			NA							Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				28	43	---	---	---	---	NA	NA	NA	NA	NA
SECISBP2L	9728	broad.mit.edu	37	15	49284568	49284598	+	Frame_Shift_Del	DEL	TCCAGCACCTCAGGCGCCTCTGCTTCCTCTT	TCCAGCACCTCAGGCGCCTCTGCTTCCTCTT	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	TCCAGCACCTCAGGCGCCTCTGCTTCCTCTT	TCCAGCACCTCAGGCGCCTCTGCTTCCTCTT	-	-	TCCAGCACCTCAGGCGCCTCTGCTTCCTCTT	TCCAGCACCTCAGGCGCCTCTGCTTCCTCTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr15:49284568_49284598delTCCAGCACCTCAGGCGCCTCTGCTTCCTCTT	uc001zxe.1	-	18	3283_3313	c.3149_3179delAAGAGGAAGCAGAGGCGCCTGAGGTGCTGGA	c.(3148-3180)GAAGAGGAAGCAGAGGCGCCTGAGGTGCTGGAGfs	p.E1050fs	SECISBP2L_uc001zxd.1_Frame_Shift_Del_p.E1005fs	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	1050_1060										breast(1)|skin(1)	2						CATCCCTGGCTCCAGCACCTCAGGCGCCTCTGCTTCCTCTTCTCCACTTTG	0.532			NA											9	21	---	---	---	---	NA	NA	NA	NA	NA
PRKCB	5579	broad.mit.edu	37	16	24231342	24231343	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:24231342_24231343insC	uc002dmd.2	+	17	2121_2122	c.1924_1925insC	c.(1924-1926)ACCfs	p.T642fs	PRKCB_uc002dme.2_3'UTR	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	642	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TGTGGAACTGACCCCCACTGAT	0.421			NA											14	36	---	---	---	---	NA	NA	NA	NA	NA
SALL1	6299	broad.mit.edu	37	16	51175948	51175948	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr16:51175948delT	uc010vgs.1	-	2	216	c.185delA	c.(184-186)AAGfs	p.K62fs	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	62					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACAGTTCTTCTTGTGGAGCAG	0.483	GBM(103;1352 1446 1855 4775 8890)		NA											24	75	---	---	---	---	NA	NA	NA	NA	NA
NCOR1	9611	broad.mit.edu	37	17	16029437	16029439	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	TTC	TTC	-	-	TTC	TTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:16029437_16029439delTTC	uc002gpo.2	-	15	1831_1833	c.1591_1593delGAA	c.(1591-1593)GAAdel	p.E531del	NCOR1_uc002gpn.2_In_Frame_Del_p.E531del|NCOR1_uc002gpp.1_In_Frame_Del_p.E422del|NCOR1_uc002gpr.2_In_Frame_Del_p.E422del|NCOR1_uc002gps.1_In_Frame_Del_p.E540del|NCOR1_uc010coz.1_In_Frame_Del_p.E347del|NCOR1_uc010cpb.1_In_Frame_Del_p.E541del|NCOR1_uc010cpa.1_In_Frame_Del_p.E532del	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	531	Potential.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		catctttcttttcttcttctttt	0.123			NA											3	6	---	---	---	---	NA	NA	NA	NA	NA
MED13	9969	broad.mit.edu	37	17	60072546	60072547	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr17:60072546_60072547insTA	uc002izo.2	-	10	2224_2225	c.2147_2148insTA	c.(2146-2148)CAAfs	p.Q716fs		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	716					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCTCACTATTTTGTCTATCTTT	0.361			NA											12	70	---	---	---	---	NA	NA	NA	NA	NA
STK11	6794	broad.mit.edu	37	19	1221314	1221314	+	Frame_Shift_Del	DEL	C	C	-	rs67873004		TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:1221314delC	uc002lrl.1	+	6	1952	c.837delC	c.(835-837)GGCfs	p.G279fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	279	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.P281fs*6(2)|p.?(2)|p.Y246fs*3(1)|p.G279F(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGACTGTGGCCCCCCGCTCT	0.607			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			7	0	---	---	---	---	NA	NA	NA	NA	NA
PLIN4	729359	broad.mit.edu	37	19	4513123	4513123	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr19:4513123delT	uc002mar.1	-	3	807	c.807delA	c.(805-807)AAAfs	p.K269fs	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	269	27 X 33 AA approximate tandem repeat.|6.					lipid particle|plasma membrane					0						GGATGGTTCCTTTGGCCACAT	0.547			NA											9	43	---	---	---	---	NA	NA	NA	NA	NA
FBXO41	150726	broad.mit.edu	37	2	73493629	73493644	+	Frame_Shift_Del	DEL	CACCTCCACGGCCCAG	CACCTCCACGGCCCAG	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CACCTCCACGGCCCAG	CACCTCCACGGCCCAG	-	-	CACCTCCACGGCCCAG	CACCTCCACGGCCCAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr2:73493629_73493644delCACCTCCACGGCCCAG	uc002sjb.1	-	3	1255_1270	c.1255_1270delCTGGGCCGTGGAGGTG	c.(1255-1272)CTGGGCCGTGGAGGTGGGfs	p.L419fs		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	358_363	Poly-Gly.					intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						CCACCGCCCCCACCTCCACGGCCCAGGCTGGCGCTG	0.685			NA											6	4	---	---	---	---	NA	NA	NA	NA	NA
DNMT3B	1789	broad.mit.edu	37	20	31383432	31383457	+	Splice_Site	DEL	CATGCCTTCTTCTTTTCTCAATAGAA	CATGCCTTCTTCTTTTCTCAATAGAA	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	CATGCCTTCTTCTTTTCTCAATAGAA	CATGCCTTCTTCTTTTCTCAATAGAA	-	-	CATGCCTTCTTCTTTTCTCAATAGAA	CATGCCTTCTTCTTTTCTCAATAGAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr20:31383432_31383457delCATGCCTTCTTCTTTTCTCAATAGAA	uc002wyc.2	+	12	1574	c.1253_splice	c.e12-1	p.E418_splice	DNMT3B_uc010ztx.1_Splice_Site|DNMT3B_uc010zty.1_Splice_Site|DNMT3B_uc002wyd.2_Splice_Site_p.E398_splice|DNMT3B_uc002wye.2_Splice_Site_p.E398_splice|DNMT3B_uc010gee.2_Splice_Site|DNMT3B_uc010gef.2_Splice_Site|DNMT3B_uc010ztz.1_Splice_Site_p.E356_splice|DNMT3B_uc010zua.1_Splice_Site_p.E322_splice|DNMT3B_uc002wyf.2_Splice_Site_p.E410_splice|DNMT3B_uc002wyg.2_Splice_Site_p.E117_splice	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform						negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						GACCTCATCTCATGCCTTCTTCTTTTCTCAATAGAACAAATGGCTT	0.535			NA											11	71	---	---	---	---	NA	NA	NA	NA	NA
ARPP21	10777	broad.mit.edu	37	3	35729270	35729270	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr3:35729270delC	uc003cgb.2	+	6	565	c.301delC	c.(301-303)CAAfs	p.Q101fs	ARPP21_uc003cga.2_Frame_Shift_Del_p.Q101fs|ARPP21_uc011axy.1_Frame_Shift_Del_p.Q101fs|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	101						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						TTCCAGCCTGCAAGAGGAGGA	0.358			NA											31	63	---	---	---	---	NA	NA	NA	NA	NA
PCDHGA10	56106	broad.mit.edu	37	5	140794944	140794944	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr5:140794944delC	uc003lkl.1	+	1	2202	c.2202delC	c.(2200-2202)GGCfs	p.G734fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Frame_Shift_Del_p.G734fs|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	734	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCAGGAGGCGGCTTGACAG	0.662			NA											67	14	---	---	---	---	NA	NA	NA	NA	NA
LRFN2	57497	broad.mit.edu	37	6	40399674	40399674	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr6:40399674delC	uc003oph.1	-	2	1644	c.1179delG	c.(1177-1179)AAGfs	p.K393fs		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	393	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGAGGCGGGACTTGGGGGGTG	0.672			NA											11	37	---	---	---	---	NA	NA	NA	NA	NA
HOXA11	3207	broad.mit.edu	37	7	27222462	27222462	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:27222462delT	uc003syx.2	-	2	967	c.895delA	c.(895-897)ATTfs	p.I299fs	HOXA10_uc003syw.3_5'Flank|HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	299	Homeobox.				branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						TCTCTGTTAATTTTTTTTTCC	0.448			NA	T	NUP98	CML								7	103	---	---	---	---	NA	NA	NA	NA	NA
COL1A2	1278	broad.mit.edu	37	7	94044553	94044553	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:94044553delT	uc003ung.1	+	30	2206	c.1735delT	c.(1735-1737)TTTfs	p.F579fs	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_5'Flank	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	579					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCATGGTGAGTTTGGTCTCCC	0.348			NA								HNSCC(75;0.22)			48	230	---	---	---	---	NA	NA	NA	NA	NA
ZAN	7455	broad.mit.edu	37	7	100391834	100391834	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr7:100391834delG	uc003uwj.2	+	45	8244	c.8079delG	c.(8077-8079)GCGfs	p.A2693fs	ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Frame_Shift_Del_p.A641fs	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2693	VWFC 5.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCTGCAGAGCGGGGGAGGTCT	0.632			NA											59	23	---	---	---	---	NA	NA	NA	NA	NA
MTUS1	57509	broad.mit.edu	37	8	17513510	17513510	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr8:17513510delT	uc003wxv.2	-	9	3444	c.2970delA	c.(2968-2970)GAAfs	p.E990fs	MTUS1_uc003wxt.2_Frame_Shift_Del_p.E237fs|MTUS1_uc011kyg.1_Frame_Shift_Del_p.E135fs|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Frame_Shift_Del_p.E936fs|MTUS1_uc003wxs.2_Frame_Shift_Del_p.E156fs	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	990	Potential.					Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GGACGAATGCTTCATACACTG	0.433			NA											35	42	---	---	---	---	NA	NA	NA	NA	NA
PRKACG	5568	broad.mit.edu	37	9	71628468	71628468	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:71628468delG	uc004agy.2	-	1	572	c.541delC	c.(541-543)CTGfs	p.L181fs		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	181	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						GTCACCTGCAGGTAGCCCTGC	0.637	Esophageal Squamous(110;2236 2623 32146)		NA											19	2	---	---	---	---	NA	NA	NA	NA	NA
STRBP	55342	broad.mit.edu	37	9	125935997	125935997	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7536-01A-11D-2063-08	TCGA-78-7536-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc90aed4-4fc8-4d4b-bed7-21a8cbb8a9ee	79b4d8aa-8de9-4af0-8ef0-609725680c1f	g.chr9:125935997delG	uc004bns.2	-	5	779	c.349delC	c.(349-351)CTGfs	p.L117fs	STRBP_uc004bnt.2_5'UTR|STRBP_uc004bnu.2_Frame_Shift_Del_p.L103fs|STRBP_uc004bnv.2_Frame_Shift_Del_p.L117fs	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	117	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						GTATTTAACAGGGTCTCTGTG	0.398			NA											60	111	---	---	---	---	NA	NA	NA	NA	NA