Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUTYH	4595	broad.mit.edu	37	1	45797139	45797139	+	Missense_Mutation	SNP	G	G	A	rs150792276	byFrequency	TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr1:45797139G>A	uc001cnm.2	-	13	1483	c.1267C>T	c.(1267-1269)CGT>TGT	p.R423C	MUTYH_uc009vxn.2_Missense_Mutation_p.R248C|MUTYH_uc001cnf.2_Missense_Mutation_p.R398C|MUTYH_uc009vxo.2_Missense_Mutation_p.R398C|MUTYH_uc001cng.2_Missense_Mutation_p.R409C|MUTYH_uc001cnj.2_Missense_Mutation_p.R306C|MUTYH_uc001cni.2_Missense_Mutation_p.R398C|MUTYH_uc001cnh.2_Missense_Mutation_p.R399C|MUTYH_uc001cno.2_Missense_Mutation_p.R306C|MUTYH_uc001cnk.2_Missense_Mutation_p.R283C|MUTYH_uc010oll.1_Missense_Mutation_p.R107C|MUTYH_uc001cnl.2_Missense_Mutation_p.R412C|MUTYH_uc009vxp.2_Missense_Mutation_p.R426C|MUTYH_uc001cnn.2_Missense_Mutation_p.R413C	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	423	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					CCAGCCCAACGCTGTAGTTCC	0.622			NA	Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				5	20					0	0	0.000602214	0	0
LRRC8D	55144	broad.mit.edu	37	1	90399791	90399791	+	Silent	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr1:90399791C>T	uc001dnm.2	+	3	1589	c.1164C>T	c.(1162-1164)TTC>TTT	p.F388F	LRRC8D_uc001dnn.2_Silent_p.F388F	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	388						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		TCTGGTTATTCAGGATACCTT	0.368			NA											22	99					0	0	0.00188189	0	0
CHIA	27159	broad.mit.edu	37	1	111861206	111861206	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr1:111861206G>A	uc001eas.2	+	9	924	c.821G>A	c.(820-822)AGC>AAC	p.S274N	CHIA_uc001ear.2_Missense_Mutation_p.S166N|CHIA_uc001eaq.2_Missense_Mutation_p.S166N|CHIA_uc009wgc.2_Missense_Mutation_p.S166N|CHIA_uc001eat.2_Missense_Mutation_p.S113N|CHIA_uc001eav.2_Missense_Mutation_p.S113N|CHIA_uc001eau.2_Missense_Mutation_p.S113N|CHIA_uc009wgd.2_Missense_Mutation_p.S113N	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	274					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		TTCATCCTGAGCAACCCCTCC	0.527			NA											29	74					0	0	0.00178596	0	0
DDX59	83479	broad.mit.edu	37	1	200635721	200635721	+	Missense_Mutation	SNP	C	C	G	rs150913822	byFrequency	TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr1:200635721C>G	uc009wzk.2	-	2	391	c.148G>C	c.(148-150)GCC>CCC	p.A50P	DDX59_uc010ppl.1_Missense_Mutation_p.A50P	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	50						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TCTATTGTGGCTGCTTCTGTA	0.507			NA											4	88					0	0	0.00024832	0	0
SORCS1	114815	broad.mit.edu	37	10	108412182	108412182	+	Silent	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr10:108412182C>T	uc001kym.2	-	18	2441	c.2433G>A	c.(2431-2433)GCG>GCA	p.A811A	SORCS1_uc001kyl.2_Silent_p.A811A|SORCS1_uc009xxs.2_Silent_p.A811A|SORCS1_uc001kyn.1_Silent_p.A811A|SORCS1_uc001kyo.2_Silent_p.A811A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	811	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GTCCTTGTTCCGCTGTCAGCT	0.522			NA											24	26					0	0	0.00106085	0	0
SLC6A5	9152	broad.mit.edu	37	11	20658729	20658729	+	Silent	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr11:20658729C>T	uc001mqd.2	+	12	2022	c.1749C>T	c.(1747-1749)ATC>ATT	p.I583I	SLC6A5_uc009yic.2_Silent_p.I348I	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	583					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TTGCCACCATCGAGACCATAG	0.498			NA											19	101					0	0	0.000295444	0	0
GPR19	2842	broad.mit.edu	37	12	12814367	12814367	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr12:12814367C>A	uc001rar.3	-	2	1209	c.1016G>T	c.(1015-1017)AGA>ATA	p.R339I	GPR19_uc001raq.2_Missense_Mutation_p.R339I	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	339	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		TTTCATCCCTCTCCGAAAATT	0.368			NA											52	52					4.0306e-16	3.3916e-15	0.000781405	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			11	9					1.49906e-05	0.000114928	0.000219431	1	0
TSHR	7253	broad.mit.edu	37	14	81609917	81609917	+	Silent	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr14:81609917C>T	uc001xvd.1	+	10	1671	c.1515C>T	c.(1513-1515)AGC>AGT	p.S505S		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	505	Helical; Name=3; (Potential).		S -> R (in HTNA; gain of function).|S -> N (in HTNA; found in toxic thyroid nodules).		cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity	p.S505N(3)		thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TCTTTGCAAGCGAGTTATCGG	0.567			NA	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						11	33					0	0	0.00136819	0	0
ASB2	51676	broad.mit.edu	37	14	94405662	94405662	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr14:94405662T>C	uc001ycc.1	-	6	1754	c.1265A>G	c.(1264-1266)TAT>TGT	p.Y422C	ASB2_uc001ycb.1_Missense_Mutation_p.Y116C|ASB2_uc001ycd.2_Missense_Mutation_p.Y470C|ASB2_uc001yce.1_Missense_Mutation_p.Y368C	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	422					intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		CGTGGCGATATAGGCGTCGAT	0.657			NA											11	31					0	0	0.00185496	0	0
Unknown	0	broad.mit.edu	37	15	28599954	28599954	+	Silent	SNP	A	A	G	rs144345425	by1000genomes	TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr15:28599954A>G	uc010uaf.1	-	4	306	c.288T>C	c.(286-288)CTT>CTC	p.L96L						SubName: Full=Putative uncharacterized protein ENSP00000383535; Flags: Fragment;												NA						GGCTGTAGTAAAGTGCCATCT	0.478			NA											3	51					0	0	6.4e-05	0	0
STRA6	64220	broad.mit.edu	37	15	74481499	74481499	+	Silent	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr15:74481499C>T	uc002axk.2	-	12	1229	c.1047G>A	c.(1045-1047)CAG>CAA	p.Q349Q	STRA6_uc002axi.2_Silent_p.Q158Q|STRA6_uc010ulh.1_Silent_p.Q387Q|STRA6_uc002axj.2_Silent_p.Q388Q|STRA6_uc010bji.2_Silent_p.Q349Q|STRA6_uc002axl.2_Silent_p.Q281Q|STRA6_uc002axm.2_Silent_p.Q349Q|STRA6_uc002axn.2_Silent_p.Q340Q|STRA6_uc010uli.1_Silent_p.Q386Q|STRA6_uc010bjj.1_RNA	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	349	Cytoplasmic (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						CCACCACCTCCTGCTTGTCCT	0.567			NA											5	22					0	0	0.00116845	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79064048	79064048	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr15:79064048C>A	uc002bej.3	-	15	2466	c.2255G>T	c.(2254-2256)GGC>GTC	p.G752V	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Missense_Mutation_p.G752V	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	752	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GATGGTCCAGCCACCATTGAG	0.647			NA											29	20					2.61193e-14	2.14552e-13	0.00178596	1	0
PRKCB	5579	broad.mit.edu	37	16	24166139	24166139	+	Silent	SNP	G	G	A	rs141827066		TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr16:24166139G>A	uc002dmd.2	+	10	1397	c.1200G>A	c.(1198-1200)CCG>CCA	p.P400P	PRKCB_uc002dme.2_Silent_p.P400P	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	400	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding	p.P400P(1)		ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CTGGGAAGCCGCCCTTCCTGA	0.567			NA											4	10					0	0	0.000602214	0	0
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	G	A	rs121913343		TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	Pancreas(47;798 1329 9957 10801)	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	12					0	0	0.00116845	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6241405	6241405	+	Silent	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr18:6241405G>A	uc002kmz.3	-	8	664	c.504C>T	c.(502-504)GCC>GCT	p.A168A	L3MBTL4_uc010dkt.2_Silent_p.A168A|L3MBTL4_uc002kmy.3_Silent_p.A6A	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	168	MBT 2.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				GCAATTTGCAGGCCTTCAAGT	0.313	Esophageal Squamous(41;748 902 17366 28959 43175)		NA											30	116					0	0	0.001512	0	0
SYT3	84258	broad.mit.edu	37	19	51133107	51133107	+	Silent	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr19:51133107G>A	uc002pst.2	-	3	1630	c.996C>T	c.(994-996)AAC>AAT	p.N332N	SYT3_uc002psv.2_Silent_p.N332N|SYT3_uc010ycd.1_Silent_p.N332N	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	332	C2 1.|Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CTGAGAAGCCGTTGGAGTCCT	0.507			NA											18	60					0	0	0.000375601	0	0
GNAS	2778	broad.mit.edu	37	20	57484421	57484421	+	Missense_Mutation	SNP	G	G	A	rs121913495		TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr20:57484421G>A	uc002xzw.2	+	8	2816	c.2531G>A	c.(2530-2532)CGT>CAT	p.R844H	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.R142H|GNAS_uc002xzx.2_Missense_Mutation_p.R142H|GNAS_uc010gjr.2_Missense_Mutation_p.R92H|GNAS_uc002xzy.2_Missense_Mutation_p.R127H|GNAS_uc002yaa.2_Missense_Mutation_p.R187H|GNAS_uc010zzt.1_Missense_Mutation_p.R202H|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Missense_Mutation_p.R92H|GNAS_uc002yae.2_Missense_Mutation_p.R126H	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	201	GTP (By similarity).		R -> L (in non-MAS endocrine tumors).|R -> S (in AIMAH, pituitary tumor and polyostotic fibrous dysplasia).|R -> H (in MAS, somatotrophinoma and AIMAH).|R -> G (in MAS).		activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity	p.R201H(37)|p.R201L(1)|p.R844H(1)		pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CTTCGCTGCCGTGTCCTGACT	0.423	Colon(117;935 1597 6045 8307 46442)		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			8	37					0	0	0.000274275	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655314	46655314	+	Silent	SNP	G	G	A	rs150338973	byFrequency	TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr22:46655314G>A	uc003bhh.2	-	1	3906	c.3906C>T	c.(3904-3906)AAC>AAT	p.N1302N		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1302	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATCGACCCTCGTTGTTGTGCC	0.453			NA											23	59					0	0	0.00047179	0	0
GALNTL2	117248	broad.mit.edu	37	3	16237394	16237394	+	Silent	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr3:16237394C>T	uc003car.3	+	2	1142	c.667C>T	c.(667-669)CTG>TTG	p.L223L	GALNTL2_uc003caq.3_5'UTR	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	223	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						CAGGGCCTTCCTGAAGGAGAT	0.617			NA											6	21					0	0	0.000274275	0	0
COL7A1	1294	broad.mit.edu	37	3	48623857	48623857	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr3:48623857C>T	uc003ctz.2	-	26	3459	c.3458G>A	c.(3457-3459)CGC>CAC	p.R1153H		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1153	Nonhelical region (NC1).|VWFA 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGCTGGCGGCGCCCAGGAGC	0.587			NA											26	83					0	0	0.00106085	0	0
HYAL2	8692	broad.mit.edu	37	3	50357600	50357600	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr3:50357600C>T	uc003czu.2	-	2	541	c.321G>A	c.(319-321)TGG>TGA	p.W107*	HYAL2_uc003czx.2_Nonsense_Mutation_p.W107*|HYAL2_uc003czv.2_Nonsense_Mutation_p.W107*|HYAL2_uc003czw.2_Nonsense_Mutation_p.W107*|HYAL2_uc010hlj.2_Nonsense_Mutation_p.W107*	NM_033158	NP_149348	Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2 precursor	107						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	TCCGGTGTGCCCAAAGGCTGA	0.572			NA											16	38					0	0	0.000958276	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741350	140741350	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr5:140741350G>A	uc003ljs.1	+	1	1648	c.1648G>A	c.(1648-1650)GTG>ATG	p.V550M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.V550M|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	550	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTGCGCGTGTTAGTGGG	0.687			NA											8	34					0	0	0.000274275	0	0
MICALL2	79778	broad.mit.edu	37	7	1478552	1478552	+	Silent	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr7:1478552C>T	uc003skj.3	-	10	2193	c.2046G>A	c.(2044-2046)CCG>CCA	p.P682P	MICALL2_uc003skh.3_5'UTR|MICALL2_uc003ski.3_Silent_p.P169P	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	682						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CAGGGGGCTCCGGCCGAAGCC	0.672			NA											8	43					0	0	0.000157383	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23352016	23352016	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr7:23352016G>T	uc003swg.2	-	15	1971	c.1705C>A	c.(1705-1707)CTG>ATG	p.L569M	IGF2BP3_uc003swf.2_Missense_Mutation_p.L188M	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	569					anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						CCACTTTGCAGAGCCTTCTGT	0.463			NA											37	123					4.16155e-14	3.33891e-13	0.00195071	1	0
AKAP9	10142	broad.mit.edu	37	7	91671477	91671477	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr7:91671477C>T	uc003ulg.2	+	19	5260	c.5035C>T	c.(5035-5037)CGC>TGC	p.R1679C	AKAP9_uc003ulf.2_Missense_Mutation_p.R1679C|AKAP9_uc003uli.2_Missense_Mutation_p.R1304C	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1691					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTGTGAGCTGCGCAACAGCAG	0.468			NA	T	BRAF	papillary thyroid								23	35					0	0	0.000586117	0	0
PTPRN2	5799	broad.mit.edu	37	7	157387931	157387931	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr7:157387931T>A	uc003wno.2	-	17	2616	c.2495A>T	c.(2494-2496)CAG>CTG	p.Q832L	PTPRN2_uc003wnp.2_Missense_Mutation_p.Q815L|PTPRN2_uc003wnq.2_Missense_Mutation_p.Q803L|PTPRN2_uc003wnr.2_Missense_Mutation_p.Q794L|PTPRN2_uc011kwa.1_Missense_Mutation_p.Q855L	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	832	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AATGTTCACCTGCCAAAAGTC	0.483			NA											27	33					0	0	0.00178596	0	0
KCNU1	157855	broad.mit.edu	37	8	36780101	36780101	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr8:36780101C>T	uc010lvw.2	+	24	2777	c.2690C>T	c.(2689-2691)ACG>ATG	p.T897M	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	897	Segment S10.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GCCTTTTCTACGGGCACTGTT	0.493			NA											15	35					0	0	0.000308642	0	0
RUSC2	9853	broad.mit.edu	37	9	35561302	35561302	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr9:35561302G>A	uc003zww.2	+	12	4729	c.4474G>A	c.(4474-4476)GAC>AAC	p.D1492N	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.D1492N	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1492	SH3.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CCGTGGCCCCGACTCTGGCCT	0.647			NA											16	22					0	0	0.000422831	0	0
SHC3	53358	broad.mit.edu	37	9	91680488	91680488	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr9:91680488G>A	uc004aqg.2	-	6	1098	c.791C>T	c.(790-792)ACT>ATT	p.T264I		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	264	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						AACATAGTCAGTTGTGTCCTG	0.453			NA											49	135					0	0	0.000781405	0	0
OR13C4	138804	broad.mit.edu	37	9	107289445	107289445	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr9:107289445C>G	uc011lvn.1	-	1	46	c.46G>C	c.(46-48)GGA>CGA	p.G16R		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCAGAGAGTCCCAGAAGAATG	0.398			NA											23	72					0	0	0.000295444	0	0
ASTN2	23245	broad.mit.edu	37	9	119976979	119976979	+	Missense_Mutation	SNP	C	C	T	rs144385545		TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr9:119976979C>T	uc004bjs.1	-	3	774	c.673G>A	c.(673-675)GTG>ATG	p.V225M	ASTN2_uc004bjr.1_Missense_Mutation_p.V225M|ASTN2_uc004bjt.1_Missense_Mutation_p.V225M	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	225	Helical; (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TACAGCGCCACGGTGAACACC	0.602			NA											13	25					0	0	0.000219431	0	0
TLR4	7099	broad.mit.edu	37	9	120476644	120476644	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr9:120476644G>T	uc004bjz.2	+	3	2529	c.2238G>T	c.(2236-2238)TGG>TGT	p.W746C	TLR4_uc004bka.2_Missense_Mutation_p.W706C|TLR4_uc004bkb.2_Missense_Mutation_p.W546C	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	746	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AGAGCCGCTGGTGTATCTTTG	0.498			NA											27	43					4.7796e-09	3.74764e-08	0.000720815	1	0
MAGED2	10916	broad.mit.edu	37	X	54837297	54837297	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chrX:54837297G>A	uc004dtk.1	+	4	675	c.581G>A	c.(580-582)AGT>AAT	p.S194N	MAGED2_uc004dtl.1_Missense_Mutation_p.S194N|MAGED2_uc004dtm.1_Missense_Mutation_p.S156N|MAGED2_uc010nkc.1_Missense_Mutation_p.S194N|MAGED2_uc004dtn.1_Missense_Mutation_p.S194N|MAGED2_uc004dto.1_Missense_Mutation_p.S168N	NM_177433	NP_803182	Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	194										ovary(2)|breast(1)	3						AGTGATCAGAGTCAGGCTTCT	0.567			NA											6	26					0	0	8.12818e-05	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282643	69282643	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chrX:69282643G>A	uc004dxu.1	+	1	303	c.269G>A	c.(268-270)CGC>CAC	p.R90H		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	90										lung(1)|skin(1)	2						CGGCCTCCCCGCTCCTCCAAA	0.577			NA											6	5					0	0	8.12818e-05	0	0
IL13RA2	3598	broad.mit.edu	37	X	114249119	114249119	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chrX:114249119G>C	uc004epx.2	-	4	390	c.265C>G	c.(265-267)CTA>GTA	p.L89V	IL13RA2_uc010nqd.1_Missense_Mutation_p.L89V	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	89	Extracellular (Potential).|Fibronectin type-III 1.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						TTGTAATGTAGATTCTTAGTA	0.353			NA											36	73					0	0	0.000692331	0	0
IL13RA2	3598	broad.mit.edu	37	X	114250375	114250375	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chrX:114250375G>A	uc004epx.2	-	3	229	c.104C>T	c.(103-105)CCT>CTT	p.P35L	IL13RA2_uc010nqd.1_Missense_Mutation_p.P35L	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	35	Extracellular (Potential).|Fibronectin type-III 1.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						AAAATCCTGAGGAGGGTTAAC	0.318			NA											13	29					0	0	0.00136819	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452831	43452832	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7540-01A-11D-2063-08	TCGA-78-7540-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6563465a-81d3-4a39-9fef-f276094d2052	6f6df2a5-d696-4051-bac1-b3407f0cdb72	g.chr2:43452831_43452832insC	uc002rsv.3	-	2	402_403	c.111_112insG	c.(109-114)GGGACGfs	p.G37fs	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	37_38					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GCCACAGGCGTCCCCACCGCCT	0.663			NA											7	9	---	---	---	---	NA	NA	NA	NA	NA