Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ATAD3B	83858	broad.mit.edu	37	1	1412655	1412655	+	Silent	SNP	T	T	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:1412655T>C	uc001afv.2	+	2	308	c.207T>C	c.(205-207)CGT>CGC	p.R69R	ATAD3B_uc001afw.2_5'Flank|ATAD3B_uc001afx.2_5'Flank	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	69	Potential.						ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CGCCCGCAGGTTACGCCAAGG	0.463			NA											9	20					0	0	0.047766	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418			NA											4	54					0	0	0.038147	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52703522	52703522	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:52703522G>T	uc001cto.2	+	4	605	c.433G>T	c.(433-435)GAG>TAG	p.E145*	ZFYVE9_uc001ctn.2_Nonsense_Mutation_p.E145*|ZFYVE9_uc001ctp.2_Nonsense_Mutation_p.E145*	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	145					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TCTGCCAGATGAGAAGAATGT	0.368			NA											31	39					1.30897e-18	1.52457e-18	0.041601	1	0
HSD3B1	3283	broad.mit.edu	37	1	120050242	120050242	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:120050242C>T	uc001ehv.1	+	2	288	c.143C>T	c.(142-144)TCT>TTT	p.S48F	HSD3B1_uc001ehw.2_Missense_Mutation_p.S50F	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	48					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	GAGGAATTTTCTAGTAAGTAA	0.473			NA											48	165					0	0	0.048971	0	0
SETDB1	9869	broad.mit.edu	37	1	150916440	150916440	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:150916440A>T	uc001evu.2	+	8	1110	c.920A>T	c.(919-921)CAG>CTG	p.Q307L	SETDB1_uc009wmf.2_Missense_Mutation_p.Q307L|SETDB1_uc001evv.2_Missense_Mutation_p.Q307L|SETDB1_uc001evw.3_Missense_Mutation_p.Q307L|SETDB1_uc009wmg.1_Missense_Mutation_p.Q307L	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	307	Tudor 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATGTCACACAGTCGGAACTG	0.413			NA											16	161					0	0	0.069288	0	0
ADCY10	55811	broad.mit.edu	37	1	167815048	167815048	+	Silent	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:167815048C>G	uc001ger.2	-	21	3058	c.2760G>C	c.(2758-2760)GTG>GTC	p.V920V	ADCY10_uc009wvk.2_Silent_p.V828V|ADCY10_uc010plj.1_Silent_p.V767V|ADCY10_uc009wvl.2_Silent_p.V919V	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	920					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GGCACTCGATCACCTCATTCT	0.502			NA											10	107					0	0	0.058154	0	0
XCL2	6846	broad.mit.edu	37	1	168510221	168510221	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:168510221G>A	uc001gfn.3	-	3	347	c.314C>T	c.(313-315)TCG>TTG	p.S105L		NM_003175	NP_003166	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2 precursor	105					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			ovary(1)	1	all_hematologic(923;0.215)					TGTATTGGTCGATTGCTGGGT	0.532			NA											7	69					0	0	0.02938	0	0
C1orf112	55732	broad.mit.edu	37	1	169816906	169816906	+	Missense_Mutation	SNP	T	T	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:169816906T>G	uc001ggp.2	+	21	2330	c.2020T>G	c.(2020-2022)TCT>GCT	p.S674A	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggq.2_Missense_Mutation_p.S674A|C1orf112_uc009wvt.2_Missense_Mutation_p.S351A|C1orf112_uc009wvu.1_Missense_Mutation_p.S550A|C1orf112_uc001ggr.2_Missense_Mutation_p.S539A|C1orf112_uc010plv.1_Missense_Mutation_p.S616A	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	674											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGATTTTGTATCTTCTTTAGG	0.343			NA											6	236					0	0	0.02938	0	0
BTG2	7832	broad.mit.edu	37	1	203276285	203276285	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:203276285C>G	uc001gzq.2	+	2	267	c.196C>G	c.(196-198)CGC>GGC	p.R66G	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	66					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			CTCCGGCTACCGCTGCATTCG	0.612			NA											13	44					0	0	0.09319	0	0
ESRRG	2104	broad.mit.edu	37	1	216824404	216824404	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:216824404G>A	uc001hkw.1	-	3	666	c.500C>T	c.(499-501)ACG>ATG	p.T167M	ESRRG_uc001hky.1_Missense_Mutation_p.T144M|ESRRG_uc009xdp.1_Missense_Mutation_p.T144M|ESRRG_uc001hkz.1_Intron|ESRRG_uc010puc.1_Missense_Mutation_p.T144M|ESRRG_uc001hla.1_Missense_Mutation_p.T144M|ESRRG_uc001hlb.1_Missense_Mutation_p.T144M|ESRRG_uc010pud.1_Translation_Start_Site|ESRRG_uc001hlc.1_Missense_Mutation_p.T144M|ESRRG_uc001hld.1_Missense_Mutation_p.T144M|ESRRG_uc001hkx.1_Missense_Mutation_p.T172M|ESRRG_uc009xdo.1_Missense_Mutation_p.T144M|ESRRG_uc001hle.1_Missense_Mutation_p.T144M	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	167	Nuclear receptor.|NR C4-type.				positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	ACATTCATTCGTGGCAGGGCA	0.418			NA											29	103					0	0	0.041601	0	0
ENAH	55740	broad.mit.edu	37	1	225702299	225702299	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr1:225702299C>T	uc001hpc.1	-	7	1670	c.1217G>A	c.(1216-1218)CGG>CAG	p.R406Q	ENAH_uc001hpd.1_Missense_Mutation_p.R406Q|ENAH_uc001hpb.1_Missense_Mutation_p.R25Q	NM_001008493	NP_001008493	Q8N8S7	ENAH_HUMAN	enabled homolog isoform a	406	EVH2.|EVH2 block A.				axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding			ovary(1)|skin(1)	2	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		GGTATTTACCCGTGACACTTT	0.323			NA											18	114					0	0	0.0333	0	0
PPRC1	23082	broad.mit.edu	37	10	103901711	103901711	+	Missense_Mutation	SNP	C	C	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr10:103901711C>A	uc001kum.2	+	5	3485	c.3446C>A	c.(3445-3447)CCA>CAA	p.P1149Q	PPRC1_uc001kun.2_Missense_Mutation_p.P1029Q|PPRC1_uc010qqj.1_Missense_Mutation_p.P1149Q|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CTGCCTACCCCACGTACTCAG	0.572			NA											7	29					4.68919e-08	5.15811e-08	0.069234	1	0
TACC2	10579	broad.mit.edu	37	10	123970013	123970013	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr10:123970013G>A	uc001lfv.2	+	9	6433	c.6073G>A	c.(6073-6075)GAT>AAT	p.D2025N	TACC2_uc001lfw.2_Missense_Mutation_p.D171N|TACC2_uc009xzx.2_Missense_Mutation_p.D1980N|TACC2_uc010qtv.1_Missense_Mutation_p.D2029N|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.D103N|TACC2_uc001lga.2_Missense_Mutation_p.D103N|TACC2_uc009xzy.2_Missense_Mutation_p.D103N|TACC2_uc001lgb.2_Missense_Mutation_p.D60N|TACC2_uc010qtw.1_Missense_Mutation_p.D120N	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2025						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGCCGTCTTCGATGAAGACAA	0.552			NA											4	26					0	0	0.009096	0	0
RIC8A	60626	broad.mit.edu	37	11	211339	211339	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr11:211339G>A	uc001log.2	+	5	1284	c.959G>A	c.(958-960)CGT>CAT	p.R320H	RIC8A_uc001lof.2_Missense_Mutation_p.R320H|RIC8A_uc001loh.2_Missense_Mutation_p.R313H	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	320						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTAGAGAAGCGTTTGCACAAG	0.562			NA											3	32					0	0	0.004672	0	0
MUC5B	727897	broad.mit.edu	37	11	1278885	1278885	+	Silent	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr11:1278885C>T	uc009ycr.1	+	63	17532	c.17406C>T	c.(17404-17406)TTC>TTT	p.F5802F	MUC5B_uc001ltb.2_Silent_p.F5468F	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5465	VWFC 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTCCCGGCTTCGTAACCGTGA	0.697			NA											3	4					0	0	0.004672	0	0
IGSF22	283284	broad.mit.edu	37	11	18737204	18737204	+	Missense_Mutation	SNP	C	C	T	rs142049851	by1000genomes	TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr11:18737204C>T	uc009yht.2	-	11	1496	c.1306G>A	c.(1306-1308)GCA>ACA	p.A436T	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	436	Ig-like 3.									ovary(4)|large_intestine(2)|kidney(1)	7						TCCAGGCATGCGCGACTCCTC	0.527			NA											4	81					0	0	0.009096	0	0
WT1	7490	broad.mit.edu	37	11	32456382	32456382	+	Silent	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr11:32456382G>C	uc001mtn.1	-	1	706	c.510C>G	c.(508-510)GGC>GGG	p.G170G	WT1_uc001mto.1_Silent_p.G170G|WT1_uc001mtp.1_Silent_p.G170G|WT1_uc001mtq.1_Silent_p.G170G|WT1_uc009yjs.1_RNA|WIT1_uc010rec.1_5'Flank|WIT1_uc010red.1_5'Flank|WIT1_uc010ree.1_5'Flank	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	102					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			CTCCGGCTGTGCCAGTGAACT	0.667			NA	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				5	19					0	0	0.014758	0	0
KBTBD4	55709	broad.mit.edu	37	11	47599133	47599133	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr11:47599133C>T	uc001nfx.2	-	2	590	c.419G>A	c.(418-420)CGC>CAC	p.R140H	NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Missense_Mutation_p.R165H|KBTBD4_uc001nfz.2_Missense_Mutation_p.R156H|KBTBD4_uc001nfy.2_Missense_Mutation_p.R140H|NDUFS3_uc010rhn.1_5'Flank|NDUFS3_uc001nga.2_5'Flank	NM_016506	NP_057590	Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	140										ovary(1)|central_nervous_system(1)	2						TTGCACTGTGCGGGCCAAAAA	0.517			NA											4	171					0	0	0.02938	0	0
OR5M1	390168	broad.mit.edu	37	11	56380559	56380559	+	Silent	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr11:56380559G>A	uc001nja.1	-	1	420	c.420C>T	c.(418-420)ATC>ATT	p.I140I		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GACAGACACAGATGTTCTTGG	0.448			NA											11	56					0	0	0.080935	0	0
CD248	57124	broad.mit.edu	37	11	66084240	66084240	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr11:66084240G>T	uc001ohm.1	-	1	276	c.259C>A	c.(259-261)CTG>ATG	p.L87M		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	87	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	TGCCGCTGCAGCCCGATCCAC	0.731			NA											4	12					3.59834e-05	3.91467e-05	0.021553	1	0
B4GALNT3	283358	broad.mit.edu	37	12	665822	665822	+	Missense_Mutation	SNP	C	C	T	rs145153320	byFrequency	TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr12:665822C>T	uc001qii.1	+	15	2170	c.2170C>T	c.(2170-2172)CGG>TGG	p.R724W	B4GALNT3_uc001qik.1_Missense_Mutation_p.R273W	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	724	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GCGCGTGGTGCGGCTCTCGGA	0.632			NA											3	38					0	0	0.004672	0	0
KCNA1	3736	broad.mit.edu	37	12	5021828	5021828	+	Silent	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr12:5021828C>T	uc001qnh.2	+	2	2389	c.1284C>T	c.(1282-1284)CTC>CTT	p.L428L		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	428					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTCAGTTGCTCCACGTCAGTT	0.502			NA											6	317					0	0	0.021553	0	0
TFCP2	7024	broad.mit.edu	37	12	51501052	51501052	+	Silent	SNP	A	A	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr12:51501052A>G	uc001rxw.2	-	7	1254	c.795T>C	c.(793-795)TAT>TAC	p.Y265Y	TFCP2_uc001rxv.1_Silent_p.Y265Y|TFCP2_uc009zlx.1_Silent_p.Y214Y|TFCP2_uc001rxx.2_Silent_p.Y265Y|TFCP2_uc009zly.1_Silent_p.Y167Y	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	265	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGGAAGGCTGATATTTCTCCT	0.338			NA											91	190					0	0	0.048971	0	0
KRT71	112802	broad.mit.edu	37	12	52942007	52942007	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr12:52942007C>T	uc001sao.2	-	5	977	c.907G>A	c.(907-909)GAA>AAA	p.E303K		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	303	Coil 2.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		GTGCGGACTTCGTCAATGATG	0.567			NA											10	85					0	0	0.058154	0	0
ACACB	32	broad.mit.edu	37	12	109698352	109698352	+	Silent	SNP	C	C	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr12:109698352C>A	uc001tob.2	+	48	6683	c.6564C>A	c.(6562-6564)CCC>CCA	p.P2188P	ACACB_uc001toc.2_Silent_p.P2188P|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.P854P	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2188	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	ACAAACAGCCCATCCTGATCT	0.537			NA											68	76					5.7554e-21	6.78316e-21	0.048971	1	0
SPPL3	121665	broad.mit.edu	37	12	121204115	121204115	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr12:121204115T>C	uc001tzd.2	-	10	1515	c.1034A>G	c.(1033-1035)TAT>TGT	p.Y345C	SPPL3_uc009zwz.2_Missense_Mutation_p.Y338C|SPPL3_uc001tzc.2_Missense_Mutation_p.Y175C	NM_139015	NP_620584	Q8TCT6	PSL4_HUMAN	signal peptide peptidase 3	346	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGGCACCAAATAGAGAAGGGC	0.522			NA											3	8					0	0	0.004672	0	0
PAN3	255967	broad.mit.edu	37	13	28855451	28855451	+	Splice_Site	SNP	G	G	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr13:28855451G>T	uc001urz.2	+	16	1890	c.1882_splice	c.e16-1	p.E628_splice	PAN3_uc001ury.2_Splice_Site_p.E462_splice|PAN3_uc001urx.2_Splice_Site_p.E574_splice	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease						nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		ATGTTTTATAGGAGGTTCAAA	0.303			NA											11	42					1.5842e-08	1.7622e-08	0.105934	1	0
AHNAK2	113146	broad.mit.edu	37	14	105418451	105418451	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr14:105418451G>A	uc010axc.1	-	7	3457	c.3337C>T	c.(3337-3339)CCC>TCC	p.P1113S	AHNAK2_uc001ypx.2_Missense_Mutation_p.P1013S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1113						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCCGCCTTGGGGCTTTTCAGG	0.647			NA											45	226					0	0	0.045515	0	0
AQP9	366	broad.mit.edu	37	15	58467128	58467128	+	Missense_Mutation	SNP	T	T	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr15:58467128T>A	uc002aez.2	+	4	745	c.388T>A	c.(388-390)TCC>ACC	p.S130T	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_Missense_Mutation_p.S65T	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9	130	Helical; (Potential).				cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		TGGACTTATGTCCTTTGCTGG	0.478			NA											9	47					0	0	0.058154	0	0
UACA	55075	broad.mit.edu	37	15	70960850	70960850	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr15:70960850C>G	uc002asr.2	-	16	2277	c.2173G>C	c.(2173-2175)GAT>CAT	p.D725H	UACA_uc010uke.1_Missense_Mutation_p.D616H|UACA_uc002asq.2_Missense_Mutation_p.D712H|UACA_uc010bin.1_Missense_Mutation_p.D700H	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	725	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						AGCTTATTATCCAAATAAACT	0.318			NA											11	84					0	0	0.069234	0	0
UACA	55075	broad.mit.edu	37	15	70961012	70961012	+	Missense_Mutation	SNP	G	G	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr15:70961012G>T	uc002asr.2	-	16	2115	c.2011C>A	c.(2011-2013)CTT>ATT	p.L671I	UACA_uc010uke.1_Missense_Mutation_p.L562I|UACA_uc002asq.2_Missense_Mutation_p.L658I|UACA_uc010bin.1_Missense_Mutation_p.L646I	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	671	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						ACATTCTCAAGTTCTCTCTTT	0.358			NA											22	97					2.44723e-14	2.78478e-14	0.099896	1	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											3	17					0	0	0.014758	0	0
SEPT12	124404	broad.mit.edu	37	16	4829784	4829784	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr16:4829784G>A	uc002cxq.2	-	8	871	c.730C>T	c.(730-732)CGA>TGA	p.R244*	SEPT12_uc002cxr.2_Nonsense_Mutation_p.R198*|SEPT12_uc010bty.2_RNA	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	244					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						AAAGGGATTCGGTCCTGGGAA	0.572			NA											21	44					0	0	0.049695	0	0
FHOD1	29109	broad.mit.edu	37	16	67265670	67265670	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr16:67265670G>A	uc002esl.2	-	15	2367	c.2255C>T	c.(2254-2256)GCC>GTC	p.A752V	FHOD1_uc002esk.2_5'Flank|FHOD1_uc010ced.2_Missense_Mutation_p.A559V	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	752	Interaction with ROCK1.|FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GGCCAGCTGGGCTTCCTCAAT	0.602			NA											6	19					0	0	0.038147	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76555040	76555040	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr16:76555040C>A	uc002feu.1	+	18	2754	c.2369C>A	c.(2368-2370)TCA>TAA	p.S790*	CNTNAP4_uc002fev.1_Nonsense_Mutation_p.S654*|CNTNAP4_uc010chb.1_Nonsense_Mutation_p.S717*|CNTNAP4_uc002fex.1_Nonsense_Mutation_p.S793*	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	790	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						AAAACAGGATCATTTTGGAAT	0.303			NA											49	93					1.35964e-18	1.56516e-18	0.048971	1	0
MYO15A	51168	broad.mit.edu	37	17	18063273	18063273	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr17:18063273C>T	uc010vxh.1	+	55	9666	c.9328C>T	c.(9328-9330)CGG>TGG	p.R3110W	MYO15A_uc010vxi.1_Missense_Mutation_p.R374W|MYO15A_uc010vxk.1_Intron|MYO15A_uc010vxl.1_Missense_Mutation_p.R99W|MYO15A_uc002gsl.2_Missense_Mutation_p.R117W|MYO15A_uc010vxm.1_Missense_Mutation_p.R32W|MYO15A_uc002gsm.1_5'Flank|MYO15A_uc010cpv.2_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3110	Tail.|MyTH4 2.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGAGGTCATGCGGGATGAATG	0.522			NA											3	20					0	0	0.014758	0	0
SUPT6H	6830	broad.mit.edu	37	17	27004785	27004785	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr17:27004785C>G	uc002hby.2	+	8	1040	c.950C>G	c.(949-951)GCT>GGT	p.A317G	SUPT6H_uc010crt.2_Missense_Mutation_p.A317G	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	317					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GAAGAAGAAGCTGACTGGATC	0.458			NA											22	179					0	0	0.076483	0	0
SSH2	85464	broad.mit.edu	37	17	27993938	27993938	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr17:27993938C>T	uc002heo.1	-	10	898	c.898G>A	c.(898-900)GTG>ATG	p.V300M	SSH2_uc010wbh.1_Missense_Mutation_p.V327M|SSH2_uc002hep.1_Missense_Mutation_p.V300M	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	300					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CCAAGGATCACTATCATTTCA	0.383			NA											34	169					0	0	0.054565	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274415	39274415	+	Silent	SNP	C	C	T	rs425487	by1000genomes	TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr17:39274415C>T	uc002hvz.2	-	1	192	c.153G>A	c.(151-153)AGG>AGA	p.R51R		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	51	6.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCACTGGGGCCTGCAGCAGC	0.667			NA											5	48					0	0	0.021553	0	0
TUBD1	51174	broad.mit.edu	37	17	57968194	57968194	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr17:57968194C>G	uc002ixw.1	-	2	448	c.170G>C	c.(169-171)GGA>GCA	p.G57A	TUBD1_uc010ddf.1_Missense_Mutation_p.G57A|TUBD1_uc010ddg.1_Missense_Mutation_p.G22A|TUBD1_uc010ddh.1_5'UTR|TUBD1_uc010wok.1_Missense_Mutation_p.G57A|TUBD1_uc002ixx.1_Missense_Mutation_p.G57A|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Missense_Mutation_p.G57A|RPS6KB1_uc010ddj.1_5'Flank|RPS6KB1_uc002ixy.2_5'Flank|RPS6KB1_uc010wom.1_5'Flank|RPS6KB1_uc010won.1_5'Flank	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	57					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			ACACCTACCTCCATTCTCCTC	0.289			NA											16	138					0	0	0.043863	0	0
TMEM104	54868	broad.mit.edu	37	17	72815930	72815930	+	Silent	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr17:72815930C>T	uc002jls.3	+	9	840	c.678C>T	c.(676-678)GAC>GAT	p.D226D	TMEM104_uc010wrf.1_Silent_p.D226D|TMEM104_uc010wrg.1_Silent_p.D239D|TMEM104_uc010dfx.2_Silent_p.D226D	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	226	Cytoplasmic (Potential).					integral to membrane					0	all_lung(278;0.23)					CCTTCTTTGACGTCCAGAAGA	0.562			NA											20	52					0	0	0.043863	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14752603	14752603	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr18:14752603A>T	uc010dlo.2	+	2	440	c.260A>T	c.(259-261)GAA>GTA	p.E87V	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	87	ANK 1.									ovary(1)|skin(1)	2						GGCCATGCAGAAGTAGTAACA	0.453			NA											3	15					0	0	0.009096	0	0
PSTPIP2	9050	broad.mit.edu	37	18	43577777	43577778	+	Missense_Mutation	DNP	GC	GC	AG			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr18:43577777_43577778GC>AG	uc002lbp.3	-	9	675_676	c.579_580GC>CT	c.(577-582)CTGCAC>CTCTAC	p.H194Y	PSTPIP2_uc002lbq.3_Missense_Mutation_p.H194Y	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting	194						membrane				ovary(1)	1						GTGCCGATGTGCAGCATGTATG	0.569			NA											28	35					0	0	0.004672	0	0
SERPINB7	8710	broad.mit.edu	37	18	61465845	61465845	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr18:61465845C>G	uc002ljl.2	+	6	558	c.462C>G	c.(460-462)ATC>ATG	p.I154M	SERPINB7_uc002ljm.2_Missense_Mutation_p.I154M|SERPINB7_uc010xet.1_Missense_Mutation_p.I137M|SERPINB7_uc010dqg.2_Missense_Mutation_p.I154M	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	154					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				AAGGCAAAATCAAGAACGTGA	0.323			NA											9	80					0	0	0.047766	0	0
ZNF548	147694	broad.mit.edu	37	19	57910809	57910809	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr19:57910809G>A	uc002qom.2	+	3	1404	c.1154G>A	c.(1153-1155)AGA>AAA	p.R385K	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.R388K	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	385	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAACATTGGAGAAATCACACT	0.438			NA											3	56					0	0	0.004672	0	0
KIF3C	3797	broad.mit.edu	37	2	26151924	26151924	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr2:26151924G>A	uc002rgu.2	-	8	2962	c.2305C>T	c.(2305-2307)CGG>TGG	p.R769W	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.R767W	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	769	Globular (Potential).				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGGAGGCCGCTGAGGACTC	0.602			NA											14	79					0	0	0.020292	0	0
NLRC4	58484	broad.mit.edu	37	2	32476011	32476011	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr2:32476011G>C	uc002roi.2	-	4	1168	c.922C>G	c.(922-924)CTC>GTC	p.L308V	NLRC4_uc002roj.1_Missense_Mutation_p.L308V|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	308	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCTCGGATGAGAGCCTGGGCG	0.532			NA											5	64					0	0	0.014758	0	0
EML4	27436	broad.mit.edu	37	2	42488319	42488319	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr2:42488319C>G	uc002rsi.2	+	4	659	c.397C>G	c.(397-399)CAT>GAT	p.H133D	EML4_uc002rsh.3_Missense_Mutation_p.H133D|EML4_uc010fap.2_Intron	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	133					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						agaggaaTCTCATTCTAATGA	0.294			NA	T	ALK	NSCLC								5	67					0	0	0.014758	0	0
SOCS5	9655	broad.mit.edu	37	2	46986084	46986084	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr2:46986084G>C	uc002rvf.2	+	2	579	c.415G>C	c.(415-417)GAT>CAT	p.D139H	SOCS5_uc010yoe.1_Missense_Mutation_p.D108H|SOCS5_uc002rvg.2_Missense_Mutation_p.D139H	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	139					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			ATTGGATGCTGATAAAAAGTT	0.458			NA											6	59					0	0	0.038147	0	0
PDE11A	50940	broad.mit.edu	37	2	178969106	178969106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr2:178969106G>A	uc002ulr.2	-	2	184	c.85C>T	c.(85-87)CAA>TAA	p.Q29*	PDE11A_uc002ult.1_Nonsense_Mutation_p.Q29*	NM_001077197	NP_001070665	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 3	Error:Variant_position_missing_in_Q9HCR9_after_alignment					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CCAGAGATTTGGACCAGTCTT	0.438			NA							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				13	134					0	0	0.020292	0	0
ZNF385B	151126	broad.mit.edu	37	2	180311403	180311403	+	Silent	SNP	T	T	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr2:180311403T>G	uc002unn.3	-	7	1369	c.765A>C	c.(763-765)CCA>CCC	p.P255P	ZNF385B_uc002unj.2_Silent_p.P153P|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.P152P|ZNF385B_uc002unm.2_Silent_p.P179P	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	255						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			CTGCTCCAGGTGGCAGGGGTG	0.453	Colon(155;204 2491 32774 51842)		NA											8	101					0	0	0.020292	0	0
GTF3C3	9330	broad.mit.edu	37	2	197629319	197629319	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr2:197629319G>C	uc002uts.2	-	18	2719	c.2629C>G	c.(2629-2631)CAA>GAA	p.Q877E	GTF3C3_uc010zgu.1_Missense_Mutation_p.Q848E	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	877						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						AAAAGCGTTTGAGCCATTCCG	0.453			NA											8	76					0	0	0.038147	0	0
PRDM15	63977	broad.mit.edu	37	21	43274737	43274737	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr21:43274737G>A	uc002yzq.1	-	12	1685	c.1574C>T	c.(1573-1575)GCG>GTG	p.A525V	PRDM15_uc002yzo.2_Missense_Mutation_p.A196V|PRDM15_uc002yzp.2_Missense_Mutation_p.A196V|PRDM15_uc002yzr.1_Missense_Mutation_p.A196V	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	525	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATAGAAGGCCGCATACCACAC	0.647			NA											4	97					0	0	0.009096	0	0
SMTN	6525	broad.mit.edu	37	22	31492754	31492754	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr22:31492754G>C	uc003ajl.1	+	14	2115	c.1897G>C	c.(1897-1899)GAG>CAG	p.E633Q	SMTN_uc003ajk.1_Missense_Mutation_p.E633Q|SMTN_uc003ajm.1_Missense_Mutation_p.E633Q|SMTN_uc011ale.1_Missense_Mutation_p.E718Q|SMTN_uc011alf.1_Missense_Mutation_p.E689Q|SMTN_uc003ajn.1_Missense_Mutation_p.E656Q|SMTN_uc011alg.1_Missense_Mutation_p.E89Q|SMTN_uc003ajo.1_Intron|SMTN_uc011alh.1_RNA|SMTN_uc010gwe.1_Intron	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	633					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						GCGGCTGCAGGAGGCACGGGG	0.677			NA											12	54					0	0	0.024245	0	0
MST1	4485	broad.mit.edu	37	3	49722464	49722464	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr3:49722464G>C	uc003cxg.2	-	14	1675	c.1603C>G	c.(1603-1605)CGG>GGG	p.R535G		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	521	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AAGCACTGCCGGGCAGTCAGT	0.592	GBM(110;181 1524 8005 22865 46297)		NA											3	12					0	0	0.004672	0	0
FRYL	285527	broad.mit.edu	37	4	48542536	48542536	+	Silent	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr4:48542536C>T	uc003gyh.1	-	46	6734	c.6129G>A	c.(6127-6129)AAG>AAA	p.K2043K	FRYL_uc003gyg.1_Silent_p.K739K|FRYL_uc003gyi.1_Silent_p.K931K|FRYL_uc003gyj.1_Silent_p.K338K	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2043					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CATTTTCAATCTTCTCTCGAC	0.383			NA											9	97					0	0	0.058154	0	0
CXXC4	80319	broad.mit.edu	37	4	105412175	105412175	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr4:105412175G>A	uc003hxg.2	-	1	293	c.278C>T	c.(277-279)GCA>GTA	p.A93V	uc003hxh.1_RNA|CXXC4_uc010ilo.2_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	93					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TGCTGAGGCTGCTGCGGGGGA	0.602			NA											23	67					0	0	0.062417	0	0
FAT1	2195	broad.mit.edu	37	4	187521354	187521354	+	Missense_Mutation	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr4:187521354G>A	uc003izf.2	-	22	11989	c.11801C>T	c.(11800-11802)TCG>TTG	p.S3934L	FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3934	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGCTGTGCCCGATGCAGTATG	0.517	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			3	46					0	0	0.004672	0	0
ZNF451	26036	broad.mit.edu	37	6	57006175	57006175	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr6:57006175C>T	uc003pdm.1	+	8	1002	c.778C>T	c.(778-780)CTT>TTT	p.L260F	ZNF451_uc003pdl.2_Missense_Mutation_p.L260F|ZNF451_uc003pdn.1_Missense_Mutation_p.L260F|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.L260F	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	260	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAATTGCTTCCTTCTTTTTAG	0.373			NA											7	32					0	0	0.02938	0	0
SHPRH	257218	broad.mit.edu	37	6	146215302	146215302	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr6:146215302C>T	uc003qlf.2	-	27	5078	c.4679G>A	c.(4678-4680)CGT>CAT	p.R1560H	SHPRH_uc003qld.2_Missense_Mutation_p.R1564H|SHPRH_uc003qle.2_Missense_Mutation_p.R1564H	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1560	Helicase C-terminal.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TGTCTTAACACGACTGATTTG	0.313			NA											6	26					0	0	0.021553	0	0
CDC14C	168448	broad.mit.edu	37	7	48965166	48965166	+	Missense_Mutation	SNP	A	A	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr7:48965166A>T	uc010kyv.1	+	1	1010	c.898A>T	c.(898-900)ATG>TTG	p.M300L		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						CTGCTACATCATGAAGCATTA	0.498			NA											5	18					0	0	0.02938	0	0
AKAP9	10142	broad.mit.edu	37	7	91712538	91712538	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr7:91712538C>T	uc003ulg.2	+	33	8440	c.8215C>T	c.(8215-8217)CAC>TAC	p.H2739Y	AKAP9_uc003ulf.2_Missense_Mutation_p.H2731Y|AKAP9_uc003uli.2_Missense_Mutation_p.H2362Y|AKAP9_uc003ulj.2_Missense_Mutation_p.H509Y|AKAP9_uc003ulk.2_Missense_Mutation_p.H14Y	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2751	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGTTAGGGATCACCTCGCAGA	0.373			NA	T	BRAF	papillary thyroid								13	87					0	0	0.09319	0	0
ORAI2	80228	broad.mit.edu	37	7	102087127	102087127	+	Silent	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr7:102087127G>A	uc010lhz.1	+	4	628	c.393G>A	c.(391-393)CTG>CTA	p.L131L	ORAI2_uc003uzj.2_Silent_p.L131L|ORAI2_uc003uzk.2_Silent_p.L131L|ORAI2_uc011kks.1_Silent_p.L54L	NM_001126340	NP_001119812	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator	131						integral to membrane	protein binding			ovary(1)|kidney(1)	2						TCCACAACCTGAACTCCATCA	0.637			NA											12	123					0	0	0.09319	0	0
CADPS2	93664	broad.mit.edu	37	7	122091483	122091483	+	Missense_Mutation	SNP	C	C	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr7:122091483C>G	uc010lkp.2	-	14	2396	c.2233G>C	c.(2233-2235)GAG>CAG	p.E745Q	CADPS2_uc011knx.1_Missense_Mutation_p.E116Q|CADPS2_uc003vkg.3_Missense_Mutation_p.E442Q|CADPS2_uc010lkq.2_Missense_Mutation_p.E742Q	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	745					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TTTATCTCCTCAAATCTTTCT	0.274			NA											3	57					0	0	0.004672	0	0
RAD54B	25788	broad.mit.edu	37	8	95403999	95403999	+	Silent	SNP	G	G	A			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr8:95403999G>A	uc003ygk.2	-	10	1745	c.1647C>T	c.(1645-1647)TGC>TGT	p.C549C	RAD54B_uc010may.1_Silent_p.C356C|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			CTCCTGGTCGGCAAAAGACAA	0.398			NA						Direct_reversal_of_damage|Homologous_recombination					4	221					0	0	0.02938	0	0
VCP	7415	broad.mit.edu	37	9	35059603	35059603	+	Missense_Mutation	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr9:35059603G>C	uc003zvy.2	-	14	2280	c.1891C>G	c.(1891-1893)CCT>GCT	p.P631A	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.P300A|VCP_uc010mki.1_Missense_Mutation_p.P586A	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	631					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGATGGCAGGATCAATGATG	0.502			NA											7	51					0	0	0.047766	0	0
TRPM6	140803	broad.mit.edu	37	9	77339635	77339635	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr9:77339635T>C	uc004ajl.1	-	39	6201	c.5963A>G	c.(5962-5964)GAA>GGA	p.E1988G	TRPM6_uc004ajk.1_Missense_Mutation_p.E1983G|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.E939G|TRPM6_uc010mpd.1_Missense_Mutation_p.E821G|TRPM6_uc010mpe.1_Missense_Mutation_p.E535G|TRPM6_uc004ajj.1_Missense_Mutation_p.E944G	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1988	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						ATTTATCCTTTCAGGGGAATA	0.408			NA											15	91					0	0	0.024245	0	0
FOXB2	442425	broad.mit.edu	37	9	79635526	79635526	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr9:79635526T>C	uc004ako.1	+	1	956	c.956T>C	c.(955-957)GTC>GCC	p.V319A		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	319					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CACGTTGGCGTCATGGATTCG	0.577			NA											2	7					0	0	0.004672	0	0
GABBR2	9568	broad.mit.edu	37	9	101052878	101052878	+	Silent	SNP	G	G	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr9:101052878G>C	uc004ays.2	-	19	2970	c.2814C>G	c.(2812-2814)GTC>GTG	p.V938V		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	938	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	ACAGGCCCGAGACCATGACTC	0.682			NA											6	5					0	0	0.058154	0	0
TOR1A	1861	broad.mit.edu	37	9	132584984	132584984	+	Missense_Mutation	SNP	C	C	T			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr9:132584984C>T	uc004byl.2	-	2	397	c.320G>A	c.(319-321)GGC>GAC	p.G107D	TOR1A_uc004bym.2_RNA|TOR1A_uc004byn.2_Missense_Mutation_p.G107D	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	107	ATP.				chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				GAAATTTTTGCCGGTGCCTGT	0.468			NA											4	206					0	0	0.021553	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070969	141070969	+	Silent	SNP	A	A	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr9:141070969A>G	uc004com.2	+	4	633	c.372A>G	c.(370-372)GCA>GCG	p.A124A	TUBBP5_uc010ncq.2_3'UTR					RecName: Full=Putative tubulin beta-4q chain;												0						TAGAAAACGCAGATGAGACCT	0.517			NA											3	34					0	0	0.009096	0	0
SSX7	280658	broad.mit.edu	37	X	52682498	52682498	+	Missense_Mutation	SNP	T	T	C			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chrX:52682498T>C	uc004dqx.1	-	2	184	c.25A>G	c.(25-27)AGG>GGG	p.R9G		NM_173358	NP_775494	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)					CTAGGTCTCCTTGCAAAGGCG	0.567			NA											8	146					0	0	0.047766	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970073	101970073	+	Silent	SNP	A	A	G			TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chrX:101970073A>G	uc004ejk.2	+	4	1610	c.276A>G	c.(274-276)GGA>GGG	p.G92G	GPRASP2_uc004ejl.2_Silent_p.G92G|GPRASP2_uc004ejm.2_Silent_p.G92G|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	92						cytoplasm	protein binding			ovary(1)	1						AGGCTCAAGGAATCACAGGGG	0.577			NA											17	64					0	0	0.038395	0	0
ERBB2	2064	broad.mit.edu	37	17	37880997	37880998	+	In_Frame_Ins	INS	-	-	TCT	rs28933369		TCGA-86-6562-01A-11D-1753-08	TCGA-86-6562-10A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	e48dd11b-89ae-4278-8de0-7956423c8609	15867b54-ec82-49b3-a442-689bda9a716d	g.chr17:37880997_37880998insTCT	uc002hso.2	+	20	2564_2565	c.2326_2327insTCT	c.(2326-2328)GGT>GTCTGT	p.776_776G>VC	ERBB2_uc002hsm.2_In_Frame_Ins_p.746_746G>VC|ERBB2_uc010cwa.2_In_Frame_Ins_p.761_761G>VC|ERBB2_uc002hsp.2_In_Frame_Ins_p.579_579G>VC|ERBB2_uc010cwb.2_In_Frame_Ins_p.776_776G>VC|ERBB2_uc010wek.1_In_Frame_Ins_p.500_500G>VC	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	776	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A775_G776insYVMA(19)|p.G776>VC(8)|p.G776>LC(3)|p.G776V(2)|p.G776S(2)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CGTGATGGCTGGTGTGGGCTCC	0.579			1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			16	54	---	---	---	---	NA	NA	NA	NA	NA