Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MFN2	9927	broad.mit.edu	37	1	12058906	12058906	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:12058906G>A	uc001atn.3	+	7	1132	c.679G>A	c.(679-681)GCC>ACC	p.A227T	MFN2_uc009vni.2_Missense_Mutation_p.A227T	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	227	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TGTGCTGGTGGCCAACTCAGA	0.562			NA											72	80					0	0	0.00361	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52941190	52941190	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:52941190T>A	uc001ctx.2	-	13	2275	c.2041A>T	c.(2041-2043)AGG>TGG	p.R681W	ZCCHC11_uc001cty.2_Missense_Mutation_p.R681W|ZCCHC11_uc001ctz.2_Missense_Mutation_p.R681W|ZCCHC11_uc009vze.1_Missense_Mutation_p.R681W|ZCCHC11_uc009vzf.1_Missense_Mutation_p.R440W|ZCCHC11_uc001cub.2_Missense_Mutation_p.R681W	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	681					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						GCAACATTCCTCTTGACTGAA	0.403			NA											8	16					0	0	0.004482	0	0
SLC44A5	204962	broad.mit.edu	37	1	75684273	75684273	+	Nonsense_Mutation	SNP	G	G	T	rs148196192		TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:75684273G>T	uc001dgu.2	-	17	1575	c.1431C>A	c.(1429-1431)TGC>TGA	p.C477*	SLC44A5_uc001dgt.2_Nonsense_Mutation_p.C477*|SLC44A5_uc001dgs.2_Nonsense_Mutation_p.C435*|SLC44A5_uc001dgr.2_Nonsense_Mutation_p.C435*|SLC44A5_uc010oqz.1_Nonsense_Mutation_p.C516*|SLC44A5_uc010ora.1_Nonsense_Mutation_p.C471*|SLC44A5_uc010orb.1_Nonsense_Mutation_p.C347*	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	477	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						CAGCAAGGGCGCACTGACCTA	0.438			NA											19	123					1.01871e-10	1.34864e-10	0.008871	1	0
FNBP1L	54874	broad.mit.edu	37	1	94014886	94014886	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:94014886C>T	uc001dpw.2	+	13	1380	c.1380C>T	c.(1378-1380)CCC>CCT	p.P460P	FNBP1L_uc001dpv.2_Silent_p.P460P|FNBP1L_uc010otk.1_Silent_p.P338P|FNBP1L_uc010otl.1_Silent_p.P88P	NM_001024948	NP_001020119	Q5T0N5	FBP1L_HUMAN	formin binding protein 1-like isoform 1	518	Interaction with CDC42.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)		GTGGGCCACCCCAGCAGCATG	0.418			NA											14	30					0	0	0.006122	0	0
MAGI3	260425	broad.mit.edu	37	1	114189171	114189171	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:114189171A>G	uc001edk.2	+	12	2243	c.2062A>G	c.(2062-2064)ATG>GTG	p.M688V	MAGI3_uc001edh.3_Missense_Mutation_p.M713V|MAGI3_uc001edi.3_Missense_Mutation_p.M688V|MAGI3_uc010owm.1_Missense_Mutation_p.M713V|MAGI3_uc001edj.2_Missense_Mutation_p.M409V	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	713					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCTCAGCCTATGCCTTTTCC	0.373			NA											34	53					0	0	0.007835	0	0
FLG	2312	broad.mit.edu	37	1	152280910	152280910	+	Missense_Mutation	SNP	C	C	T	rs146106776		TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:152280910C>T	uc001ezu.1	-	3	6488	c.6452G>A	c.(6451-6453)GGG>GAG	p.G2151E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2151	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGTGGGACCCCTGTCTTCC	0.582			NA							Ichthyosis				293	186					0	0	0.00361	0	0
PKLR	5313	broad.mit.edu	37	1	155271116	155271116	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:155271116G>T	uc001fkb.3	-	1	110	c.71C>A	c.(70-72)GCA>GAA	p.A24E	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_5'Flank|PKLR_uc010pga.1_5'Flank	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	24					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GATGGACTTTGCTAAGTCTCT	0.537			NA											67	36					6.20995e-33	1.04849e-32	0.00361	1	0
SPTA1	6708	broad.mit.edu	37	1	158653173	158653173	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:158653173G>A	uc001fst.1	-	3	577	c.378C>T	c.(376-378)CAC>CAT	p.H126H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	126	Spectrin 2.			Missing (in Ref. 3; AAA60575).	actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCGTTTCTTCGTGGGCAGAAT	0.383			NA											80	50					0	0	0.00361	0	0
IGSF8	93185	broad.mit.edu	37	1	160061724	160061724	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:160061724C>T	uc001fva.2	-	6	1776	c.1731G>A	c.(1729-1731)CTG>CTA	p.L577L	IGSF8_uc001fuz.2_Silent_p.L577L|IGSF8_uc009wtf.2_Silent_p.L577L	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	577	Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			ATAGGGTGTCCAGGGCTGGGG	0.562			NA											29	25					0	0	0.00632	0	0
CASQ1	844	broad.mit.edu	37	1	160171074	160171074	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:160171074C>T	uc010pja.1	+	11	1356	c.1099C>T	c.(1099-1101)CTG>TTG	p.L367L		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	367	Asp-rich.					mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGAGGAGGACCTGCCTTCTGC	0.547			NA											14	9					0	0	0.003163	0	0
F11R	50848	broad.mit.edu	37	1	160969998	160969998	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:160969998G>A	uc009wtt.2	-	5	799	c.529C>T	c.(529-531)CCC>TCC	p.P177S	F11R_uc010pjv.1_Missense_Mutation_p.P128S|F11R_uc001fxe.3_Missense_Mutation_p.P177S|F11R_uc009wtu.2_Missense_Mutation_p.P177S|F11R_uc010pjw.1_Missense_Mutation_p.P181S|F11R_uc001fxf.3_Missense_Mutation_p.P177S	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	177	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			GTGCTTTTGGGATTCGTAGGC	0.517			NA											38	84					0	0	0.004289	0	0
DCAF6	55827	broad.mit.edu	37	1	168032861	168032861	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:168032861G>T	uc001gew.2	+	15	2272	c.2030G>T	c.(2029-2031)CGC>CTC	p.R677L	DCAF6_uc001gev.2_Missense_Mutation_p.R697L|DCAF6_uc001gex.2_Missense_Mutation_p.R768L|DCAF6_uc010plk.1_Missense_Mutation_p.R737L|DCAF6_uc001gey.2_Missense_Mutation_p.R550L|DCAF6_uc001gez.2_5'UTR	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	677	IQ.				positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCATATAGACGCTCTGCTGTT	0.294			NA											6	9					5.9392e-07	7.2452e-07	0.001168	1	0
KIFAP3	22920	broad.mit.edu	37	1	170015993	170015993	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:170015993C>A	uc001ggv.2	-	3	450	c.179G>T	c.(178-180)AGT>ATT	p.S60I	KIFAP3_uc010ply.1_5'UTR|KIFAP3_uc001ggw.1_Missense_Mutation_p.S16I	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	60					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGCATTGAGACTCTTAAGTCG	0.308			NA											42	26					6.1244e-12	8.29643e-12	0.007835	1	0
MYOC	4653	broad.mit.edu	37	1	171621320	171621320	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:171621320G>T	uc001ghu.2	-	1	454	c.432C>A	c.(430-432)AAC>AAA	p.N144K	MYOC_uc010pmk.1_Missense_Mutation_p.N86K	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	144	Potential.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTCGGAGGAGGTTGCTGTAGG	0.582			NA											33	139					3.80469e-20	5.71931e-20	0.001786	1	0
PAPPA2	60676	broad.mit.edu	37	1	176664879	176664879	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:176664879C>A	uc001gkz.2	+	7	3794	c.2630C>A	c.(2629-2631)TCA>TAA	p.S877*	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	877					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCCAGGGCCTCAGGCAGCTTG	0.537			NA											88	53					9.45097e-43	1.68097e-42	0.00361	1	0
ASPM	259266	broad.mit.edu	37	1	197101446	197101446	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:197101446T>C	uc001gtu.2	-	7	2713	c.2456A>G	c.(2455-2457)TAC>TGC	p.Y819C	ASPM_uc001gtv.2_Missense_Mutation_p.Y819C|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	819					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CAAAGGATTGTAGGACAACAG	0.308			NA											22	45					0	0	0.005443	0	0
KDM5B	10765	broad.mit.edu	37	1	202733256	202733256	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:202733256T>C	uc001gyf.2	-	6	845	c.729A>G	c.(727-729)ATA>ATG	p.I243M	KDM5B_uc009xag.2_Missense_Mutation_p.I279M|KDM5B_uc001gyg.1_Missense_Mutation_p.I85M	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	243					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CCTCGGGTTCTATTTTAATAT	0.333			NA											10	55					0	0	0.000978	0	0
USH2A	7399	broad.mit.edu	37	1	216062172	216062172	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:216062172C>A	uc001hku.1	-	41	8206	c.7819G>T	c.(7819-7821)GGA>TGA	p.G2607*		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2607	Fibronectin type-III 12.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGGAACATCCTTTTGAAGTG	0.473			NA								HNSCC(13;0.011)			62	37					5.19286e-32	8.70458e-32	0.00361	1	0
LEFTY1	10637	broad.mit.edu	37	1	226074602	226074602	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:226074602G>A	uc001hpo.2	-	4	996	c.926C>T	c.(925-927)CCG>CTG	p.P309L	LEFTY1_uc010pvj.1_3'UTR	NM_020997	NP_066277	O75610	LFTY1_HUMAN	left-right determination, factor B	309					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					CCCCAGAAACGGCCACTTGAA	0.667			NA											4	35					0	0	0.000248	0	0
PCNXL2	80003	broad.mit.edu	37	1	233388166	233388166	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:233388166C>A	uc001hvl.2	-	7	2297	c.2062G>T	c.(2062-2064)GGG>TGG	p.G688W	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA|PCNXL2_uc001hvq.1_5'UTR	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	688						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GTTTCAGGCCCACTGATGACT	0.388			NA											16	81					1.99824e-07	2.45047e-07	0.00499	1	0
OR2M5	127059	broad.mit.edu	37	1	248308515	248308515	+	Silent	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:248308515C>A	uc010pze.1	+	1	66	c.66C>A	c.(64-66)CCC>CCA	p.P22P		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ATCACAGCCCCACCCACACCT	0.478			NA											227	141					3.87791e-117	7.00429e-117	0.00361	1	0
C10orf18	54906	broad.mit.edu	37	10	5790473	5790473	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:5790473G>T	uc001iij.2	+	15	5714	c.5089G>T	c.(5089-5091)GGT>TGT	p.G1697C	C10orf18_uc001iik.2_Missense_Mutation_p.G541C	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1697										ovary(1)|central_nervous_system(1)	2						GCTTAAGAATGGTGAGCCTGA	0.458			NA											25	37					7.87624e-14	1.11222e-13	0.00278	1	0
LOC387646	387646	broad.mit.edu	37	10	27538535	27538535	+	Silent	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:27538535G>T	uc001its.2	-	1	2701	c.858C>A	c.(856-858)CCC>CCA	p.P286P		NR_003525				SubName: Full=cDNA FLJ44924 fis, clone BRAMY3014555;												0						CCTCCGTAGTGGGTTCTGGAG	0.498			NA											90	132					9.24773e-40	1.63236e-39	0.00361	1	0
ADAMTS14	140766	broad.mit.edu	37	10	72489080	72489080	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:72489080G>C	uc001jrh.2	+	5	901	c.901G>C	c.(901-903)GGG>CGG	p.G301R	ADAMTS14_uc001jrg.2_Missense_Mutation_p.G301R|ADAMTS14_uc010qjl.1_RNA	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	301	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGAGTCCCTGGGGGTTCATAT	0.398			NA											26	52					0	0	0.008361	0	0
SLC29A3	55315	broad.mit.edu	37	10	73082704	73082704	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:73082704C>T	uc001jrr.3	+	2	250	c.193C>T	c.(193-195)CTA>TTA	p.L65L	SLC29A3_uc001jrs.3_Silent_p.L65L|SLC29A3_uc010qjq.1_5'UTR|SLC29A3_uc001jrt.3_5'UTR|SLC29A3_uc001jru.3_Intron	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	65	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CATTGGCAGTCTACTGCCATG	0.597	Esophageal Squamous(200;1319 2142 18949 31248 39672)		NA											5	78					0	0	0.001168	0	0
PSAP	5660	broad.mit.edu	37	10	73587857	73587857	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:73587857C>G	uc001jsm.2	-	6	738	c.634G>C	c.(634-636)GTA>CTA	p.V212L		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	212	Saposin B-type 2.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						TTGGTCCGTACAGCAGTCTGG	0.532			NA											31	57					0	0	0.002836	0	0
SFTPA1	653509	broad.mit.edu	37	10	81372125	81372125	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:81372125G>T	uc001kap.2	+	4	351	c.230G>T	c.(229-231)GGA>GTA	p.G77V	SFTPA1_uc001kaq.2_Missense_Mutation_p.G77V|SFTPA1_uc009xry.2_Missense_Mutation_p.G92V|SFTPA1_uc001kar.2_Missense_Mutation_p.G77V|SFTPA1_uc010qlt.1_Missense_Mutation_p.G18V|SFTPA1_uc009xrz.2_Intron|SFTPA1_uc009xsa.2_Missense_Mutation_p.G77V|SFTPA1_uc009xsf.2_5'Flank	NM_005411	NP_005402	Q8IWL2	SFTA1_HUMAN	surfactant protein A1 isoform 1	77	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GGGCTGCCTGGAGCCCCTGGT	0.612			NA											71	130					8.13855e-26	1.32607e-25	0.00361	1	0
CRTAC1	55118	broad.mit.edu	37	10	99664469	99664469	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:99664469C>A	uc001kou.1	-	7	1309	c.953G>T	c.(952-954)CGC>CTC	p.R318L	CRTAC1_uc001kov.2_Missense_Mutation_p.R307L|CRTAC1_uc001kot.1_Missense_Mutation_p.R108L	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	318	FG-GAP 3; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CAGATAGAGGCGGTGGGGGCC	0.498			NA											39	73					1.8453e-21	2.84738e-21	0.002522	1	0
HPSE2	60495	broad.mit.edu	37	10	100481488	100481488	+	Silent	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:100481488C>A	uc001kpn.1	-	5	942	c.882G>T	c.(880-882)CGG>CGT	p.R294R	HPSE2_uc009xwc.1_Silent_p.R284R|HPSE2_uc001kpo.1_Silent_p.R226R|HPSE2_uc009xwd.1_Silent_p.R172R	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	294					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TGGAATAAATCCGGATGGGCT	0.493			NA											28	42					1.17739e-12	1.62327e-12	0.005443	1	0
FGF8	2253	broad.mit.edu	37	10	103530295	103530295	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:103530295C>T	uc001ktp.1	-	6	663	c.493G>A	c.(493-495)GAG>AAG	p.E165K	FGF8_uc001ktq.1_Missense_Mutation_p.E176K|FGF8_uc001ktr.1_Missense_Mutation_p.E147K|FGF8_uc001kts.1_Missense_Mutation_p.E136K|FGF8_uc009xwr.1_Missense_Mutation_p.E72K	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	165					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		TACCAGCCCTCGTACTTGGCA	0.627			NA											15	28					0	0	0.00499	0	0
FGFR2	2263	broad.mit.edu	37	10	123279634	123279634	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:123279634G>A	uc010qtk.1	-	7	1445	c.798C>T	c.(796-798)GCC>GCT	p.A266A	FGFR2_uc010qtg.1_Intron|FGFR2_uc010qth.1_Silent_p.A151A|FGFR2_uc010qti.1_Silent_p.A177A|FGFR2_uc010qtj.1_Silent_p.A266A|FGFR2_uc010qtl.1_Silent_p.A266A|FGFR2_uc010qtm.1_Silent_p.A151A|FGFR2_uc001lfl.3_Silent_p.A266A|FGFR2_uc001lfm.2_Silent_p.A177A|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Silent_p.A285A|FGFR2_uc010qto.1_Silent_p.A170A|FGFR2_uc001lfo.1_Silent_p.A285A|FGFR2_uc010qtp.1_Silent_p.A285A|FGFR2_uc001lfg.3_5'Flank	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	266	Ig-like C2-type 3.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CCACTGTGGAGGCATTTGCCG	0.577			5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				5	43					0	0	0.000602	0	0
DMBT1	1755	broad.mit.edu	37	10	124338238	124338238	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:124338238T>G	uc001lgk.1	+	9	748	c.642T>G	c.(640-642)AGT>AGG	p.S214R	DMBT1_uc001lgl.1_Missense_Mutation_p.S214R|DMBT1_uc001lgm.1_Missense_Mutation_p.S214R|DMBT1_uc009xzz.1_Missense_Mutation_p.S214R|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.S66R	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	214					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTACAGAAAGTTGGCCTGTCA	0.448	Ovarian(182;93 2026 18125 22222 38972)		NA											7	12					0	0	0.00308	0	0
MKI67	4288	broad.mit.edu	37	10	129902508	129902508	+	Silent	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:129902508G>T	uc001lke.2	-	13	7791	c.7596C>A	c.(7594-7596)ATC>ATA	p.I2532I	MKI67_uc001lkf.2_Silent_p.I2172I|MKI67_uc009yav.1_Silent_p.I2107I|MKI67_uc009yaw.1_Silent_p.I1682I	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2532	16 X 122 AA approximate repeats.|13.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTGGGTCCAGGATCTGCTTTG	0.512			NA											74	107					2.08929e-35	3.60595e-35	0.00361	1	0
MUC6	4588	broad.mit.edu	37	11	1025300	1025300	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:1025300C>G	uc001lsw.2	-	23	2918	c.2867G>C	c.(2866-2868)GGG>GCG	p.G956A		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	956	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGGCGTCACCCCGAGCTGCAC	0.642			NA											10	51					0	0	0.006214	0	0
OR2D3	120775	broad.mit.edu	37	11	6942999	6942999	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:6942999C>T	uc010rav.1	+	1	767	c.767C>T	c.(766-768)ACC>ATC	p.T256I		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCTTTTTCCACCTGTGGCTCC	0.453			NA											5	43					0	0	0.000602	0	0
CTR9	9646	broad.mit.edu	37	11	10778300	10778300	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:10778300A>C	uc001mja.2	+	5	656	c.507A>C	c.(505-507)AAA>AAC	p.K169N		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	169	TPR 3.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TTACAGGTAAAGCTTGCATTT	0.333			NA											18	49					0	0	0.007413	0	0
SOX6	55553	broad.mit.edu	37	11	16010775	16010775	+	Silent	SNP	T	T	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:16010775T>G	uc001mme.2	-	14	1806	c.1773A>C	c.(1771-1773)GGA>GGC	p.G591G	SOX6_uc001mmd.2_Silent_p.G554G|SOX6_uc001mmf.2_Silent_p.G551G|SOX6_uc001mmg.2_Intron	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	578					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						TTGCTTTACTTCCTGTAATGT	0.502			NA									OREG0020800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	19					0	0	0.007413	0	0
PAX6	5080	broad.mit.edu	37	11	31823152	31823152	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:31823152C>A	uc001mtd.3	-	5	1204	c.314G>T	c.(313-315)AGA>ATA	p.R105I	PAX6_uc001mte.3_Missense_Mutation_p.R105I|PAX6_uc001mtg.3_Missense_Mutation_p.R119I|PAX6_uc001mtf.3_Missense_Mutation_p.R105I|PAX6_uc001mth.3_Missense_Mutation_p.R105I|PAX6_uc009yjr.2_Missense_Mutation_p.R105I	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	105	Paired.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					GGACAGTAATCTGTCTCGGAT	0.502			NA							Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				15	52					2.23348e-06	2.66873e-06	0.004007	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136650	40136650	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:40136650G>T	uc001mxa.1	-	2	3157	c.1193C>A	c.(1192-1194)GCG>GAG	p.A398E	LRRC4C_uc001mxc.1_Missense_Mutation_p.A394E|LRRC4C_uc001mxd.1_Missense_Mutation_p.A394E|LRRC4C_uc001mxb.1_Missense_Mutation_p.A394E	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	398	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CACTTTGTACGCCCCATGTGT	0.463			NA											55	87					4.32865e-36	7.52668e-36	0.00361	1	0
PACSIN3	29763	broad.mit.edu	37	11	47201066	47201066	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:47201066T>A	uc001ndw.2	-	7	1013	c.675A>T	c.(673-675)GAA>GAT	p.E225D	ARFGAP2_uc001ndt.2_5'Flank|ARFGAP2_uc010rhb.1_5'Flank|ARFGAP2_uc001ndu.2_5'Flank|ARFGAP2_uc010rhc.1_5'Flank|ARFGAP2_uc010rhd.1_5'Flank|ARFGAP2_uc001ndv.1_5'Flank|PACSIN3_uc001ndx.2_Missense_Mutation_p.E225D|PACSIN3_uc001ndy.2_Missense_Mutation_p.E225D|PACSIN3_uc001ndz.2_RNA|PACSIN3_uc001nea.2_RNA	NM_016223	NP_057307	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in	225					endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding				0						CAAAGGCCTGTTCCATGTCCT	0.582			NA									OREG0020952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	43					0	0	0.001523	0	0
OR4C16	219428	broad.mit.edu	37	11	55340174	55340174	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:55340174T>A	uc010rih.1	+	1	571	c.571T>A	c.(571-573)TAT>AAT	p.Y191N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TTCAGAAACCTATGTGGTTAA	0.438			NA											42	50					0	0	0.00361	0	0
PAK1	5058	broad.mit.edu	37	11	77054934	77054934	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr11:77054934C>A	uc001oyh.3	-	10	1461	c.928G>T	c.(928-930)GAG>TAG	p.E310*	PAK1_uc010rso.1_Nonsense_Mutation_p.E212*|PAK1_uc001oyg.3_Nonsense_Mutation_p.E310*|PAK1_uc001oyi.1_Nonsense_Mutation_p.E310*|PAK1_uc010rsn.1_Nonsense_Mutation_p.E23*	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	310	Protein kinase.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					ATAATCAGCTCTTTCTTGGGC	0.398			NA											18	76					1.2644e-06	1.53441e-06	0.001523	1	0
TAS2R9	50835	broad.mit.edu	37	12	10962433	10962433	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:10962433A>G	uc001qyx.2	-	1	335	c.242T>C	c.(241-243)CTA>CCA	p.L81P	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	81	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						AATGCTTACTAGCACGCTATT	0.398			NA											52	52					0	0	0.00361	0	0
HEBP1	50865	broad.mit.edu	37	12	13140126	13140126	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:13140126C>T	uc001rbd.2	-	3	531	c.358G>A	c.(358-360)GTT>ATT	p.V120I	HEBP1_uc001rbf.2_Missense_Mutation_p.V120I	NM_015987	NP_057071	Q9NRV9	HEBP1_HUMAN	heme binding protein 1	120					circadian rhythm	extracellular region				breast(1)	1		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		TCAATCTTAACGCTTTTGTCA	0.488			NA											20	142					0	0	0.001523	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			12	22					1.49906e-05	1.72911e-05	0.00245	1	0
ANO6	196527	broad.mit.edu	37	12	45725191	45725191	+	Silent	SNP	A	A	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:45725191A>C	uc001roo.2	+	3	599	c.264A>C	c.(262-264)ACA>ACC	p.T88T	ANO6_uc010sld.1_Silent_p.T88T|ANO6_uc010sle.1_Silent_p.T88T|ANO6_uc010slf.1_Silent_p.T109T|ANO6_uc010slg.1_Silent_p.T70T	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	88	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						AAAAGGGTACAAATGAAAAAC	0.299			NA											13	24					0	0	0.00245	0	0
COL2A1	1280	broad.mit.edu	37	12	48387269	48387269	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:48387269G>A	uc001rqu.2	-	15	1122	c.941C>T	c.(940-942)CCG>CTG	p.P314L	COL2A1_uc001rqv.2_Missense_Mutation_p.P245L	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	314	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GTTCTCACCCGGGGAACCACT	0.542			NA											7	35					0	0	0.001984	0	0
EIF4B	1975	broad.mit.edu	37	12	53427616	53427616	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:53427616C>G	uc001sbh.3	+	9	1212	c.1006C>G	c.(1006-1008)CTA>GTA	p.L336V	EIF4B_uc010snu.1_Missense_Mutation_p.L336V|EIF4B_uc010snv.1_Missense_Mutation_p.L297V|EIF4B_uc001sbi.2_Missense_Mutation_p.L88V	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	336					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						CAAACTGAATCTAAAGCCTCG	0.458			NA											13	40					0	0	0.001855	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041052	64041052	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:64041052G>C	uc001srp.1	-	5	863	c.682C>G	c.(682-684)CCT>GCT	p.P228A	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	228					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TCATTAAGAGGTTCTATTCTG	0.318			NA											19	39					0	0	0.001523	0	0
PTPRB	5787	broad.mit.edu	37	12	71029742	71029742	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:71029742A>G	uc001swc.3	-	2	204	c.160T>C	c.(160-162)TGG>CGG	p.W54R	PTPRB_uc001swa.3_Missense_Mutation_p.W54R|PTPRB_uc001swd.3_Missense_Mutation_p.W53R|PTPRB_uc009zrr.1_Missense_Mutation_p.W54R|PTPRB_uc001swe.2_Missense_Mutation_p.W54R	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCCTCAGTCCACATCCACTGC	0.512			NA											8	14					0	0	0.004482	0	0
KCNC2	3747	broad.mit.edu	37	12	75601467	75601467	+	Silent	SNP	G	G	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:75601467G>C	uc001sxg.1	-	2	841	c.297C>G	c.(295-297)GGC>GGG	p.G99G	KCNC2_uc009zry.2_Silent_p.G99G|KCNC2_uc001sxe.2_Silent_p.G99G|KCNC2_uc001sxf.2_Silent_p.G99G|KCNC2_uc010stw.1_Silent_p.G99G	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	99	Gly/Pro-rich (insert).|Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AGAACTCGCGGCCGCCACCGG	0.652			NA											4	6					0	0	0.001168	0	0
DNAH10	196385	broad.mit.edu	37	12	124414242	124414242	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr12:124414242C>T	uc001uft.3	+	71	12219	c.12194C>T	c.(12193-12195)ACG>ATG	p.T4065M	DNAH10_uc001ufu.3_Translation_Start_Site	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4065					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACGTACTTAACGAAAGCCTTC	0.507			NA											4	23					0	0	0.000248	0	0
CDK8	1024	broad.mit.edu	37	13	26974666	26974666	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr13:26974666A>T	uc001uqr.1	+	10	1036	c.1010A>T	c.(1009-1011)GAA>GTA	p.E337V	CDK8_uc001uqs.1_Missense_Mutation_p.E337V|CDK8_uc001uqt.1_Missense_Mutation_p.E164V	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		TATTTCTTAGAAGACCCACTT	0.423			NA											47	33					0	0	0.00361	0	0
TDRD3	81550	broad.mit.edu	37	13	61103023	61103023	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr13:61103023A>G	uc001via.2	+	11	2173	c.1385A>G	c.(1384-1386)AAT>AGT	p.N462S	TDRD3_uc010aef.2_Missense_Mutation_p.N287S|TDRD3_uc001vhz.3_Missense_Mutation_p.N462S|TDRD3_uc010aeg.2_Missense_Mutation_p.N555S|TDRD3_uc001vib.3_Missense_Mutation_p.N461S	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	462					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		CAAACAATAAATAATGAAGCT	0.284	Colon(36;164 906 35820 50723)		NA											34	19					0	0	0.002836	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454777	84454778	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr13:84454777_84454778GG>AT	uc001vlk.2	-	1	1751_1752	c.865_866CC>AT	c.(865-867)CCT>ATT	p.P289I		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	289	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TGTCTTGAAAGGAGTTGGCAGG	0.54			NA											12	15					0	0	0.004672	0	0
RABGGTA	5875	broad.mit.edu	37	14	24738879	24738879	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:24738879C>T	uc001wof.2	-	5	871	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.R150Q|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	150	PFTA 3.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		GGCCACAAACCGCCGATAGTC	0.582			NA											11	21					0	0	0.001368	0	0
AKAP6	9472	broad.mit.edu	37	14	33291383	33291383	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:33291383G>C	uc001wrq.2	+	13	4534	c.4364G>C	c.(4363-4365)GGA>GCA	p.G1455A		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1455					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GACTGTTTGGGAGAAGAATTA	0.363	Melanoma(49;821 1200 7288 13647 42351)		NA											24	38					0	0	0.00278	0	0
MDGA2	161357	broad.mit.edu	37	14	47566205	47566205	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:47566205G>A	uc001wwj.3	-	6	1036	c.840C>T	c.(838-840)TCC>TCT	p.S280S	MDGA2_uc001wwi.3_Silent_p.S51S|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	280	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GAGTCCCAAAGGACCTGACCC	0.468			NA											30	58					0	0	0.001786	0	0
RTN1	6252	broad.mit.edu	37	14	60194383	60194384	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:60194383_60194384GG>CT	uc001xen.1	-	3	1227_1228	c.1018_1019CC>AG	c.(1018-1020)CCA>AGA	p.P340R	RTN1_uc001xem.1_5'UTR	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	340					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TGCAGCAGATGGTTCTGTCGTC	0.53			NA											7	11					0	0	0.004672	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68274527	68274527	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:68274527C>A	uc001xka.2	-	5	613	c.474G>T	c.(472-474)TGG>TGT	p.W158C	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.W158C|ZFYVE26_uc010tta.1_Missense_Mutation_p.W158C	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	158					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCAGGAGATCCCAGAGCACAG	0.602			NA											69	62					5.80444e-35	9.94436e-35	0.00361	1	0
FLRT2	23768	broad.mit.edu	37	14	86088584	86088584	+	Silent	SNP	G	G	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:86088584G>C	uc001xvr.2	+	2	1493	c.726G>C	c.(724-726)CTG>CTC	p.L242L	FLRT2_uc010atd.2_Silent_p.L242L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	242	Extracellular (Potential).|LRR 8.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GTAATTCGCTGTCCCACCCTC	0.502			NA											47	61					0	0	0.002522	0	0
C14orf159	80017	broad.mit.edu	37	14	91671070	91671070	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:91671070G>A	uc001xzb.2	+	14	2218	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	C14orf159_uc001xyx.2_Intron|C14orf159_uc001xyw.2_Missense_Mutation_p.E489K|C14orf159_uc001xzc.2_Missense_Mutation_p.E484K|C14orf159_uc001xza.2_Missense_Mutation_p.E489K|C14orf159_uc001xyv.2_Intron|C14orf159_uc001xyz.2_Missense_Mutation_p.E360K|C14orf159_uc001xze.2_Missense_Mutation_p.E484K	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	484						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		TGGAGGCAACGAGCTTGGGAT	0.602			NA											5	11					0	0	0.000602	0	0
SERPINA3	12	broad.mit.edu	37	14	95090116	95090116	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:95090116T>C	uc001ydp.2	+	5	1316	c.1237T>C	c.(1237-1239)TTC>CTC	p.F413L	SERPINA3_uc001ydo.3_Missense_Mutation_p.F438L|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.F413L|SERPINA3_uc001yds.2_Missense_Mutation_p.F413L|SERPINA3_uc010avg.2_Missense_Mutation_p.F413L	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	413					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GAACATCTTCTTCATGAGCAA	0.498			NA											4	108					0	0	0.000602	0	0
CKB	1152	broad.mit.edu	37	14	103988639	103988639	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr14:103988639C>T	uc001ynf.1	-	2	272	c.192G>A	c.(190-192)CCG>CCA	p.P64P	CKB_uc001yne.1_5'Flank|CKB_uc010awr.1_Intron	NM_001823	NP_001814	P12277	KCRB_HUMAN	brain creatine kinase	64	Phosphagen kinase N-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity				0		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	GTCGCGTACCCGGGTTGTCCA	0.577	Esophageal Squamous(186;2492 2823 49929 50127)		NA											5	13					0	0	0.000602	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32929215	32929215	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr15:32929215C>G	uc001zgy.1	+	12	2963	c.2241C>G	c.(2239-2241)AAC>AAG	p.N747K	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.N558K|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.N558K	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	747					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TGGAAGGTAACTTACCGAAGT	0.383	Colon(45;757 1134 30003 36652)		NA											22	36					0	0	0.001882	0	0
SLC12A1	6557	broad.mit.edu	37	15	48551450	48551450	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr15:48551450A>T	uc001zwn.3	+	17	2312	c.2096A>T	c.(2095-2097)GAC>GTC	p.D699V	SLC12A1_uc010uew.1_Missense_Mutation_p.D505V|SLC12A1_uc010bem.2_Missense_Mutation_p.D699V|SLC12A1_uc001zwq.3_Missense_Mutation_p.D470V|SLC12A1_uc001zwr.3_Missense_Mutation_p.D426V	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	699					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GCTCTCCTGGACATAACTCAC	0.502			NA											34	89					0	0	0.004878	0	0
DENND4A	10260	broad.mit.edu	37	15	65983463	65983463	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr15:65983463C>A	uc002aph.2	-	22	3715	c.3337G>T	c.(3337-3339)GAT>TAT	p.D1113Y	DENND4A_uc002api.2_Missense_Mutation_p.D1156Y|DENND4A_uc002apj.3_Missense_Mutation_p.D1113Y	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TCCACTTTATCTGCCAAATAG	0.363			NA											9	22					2.74318e-10	3.57073e-10	0.006214	1	0
ARNT2	9915	broad.mit.edu	37	15	80847406	80847406	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr15:80847406G>C	uc002bfr.2	+	11	1256	c.1090G>C	c.(1090-1092)GAT>CAT	p.D364H	ARNT2_uc010unm.1_Missense_Mutation_p.D353H|ARNT2_uc002bfs.2_Missense_Mutation_p.D353H	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	364	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			TTTTATTTAGGATCTTCTGGG	0.398			NA											33	97					0	0	0.002836	0	0
FES	2242	broad.mit.edu	37	15	91437239	91437239	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr15:91437239C>T	uc002bpv.2	+	18	2373	c.2277C>T	c.(2275-2277)TCC>TCT	p.S759S	FES_uc010uqj.1_Silent_p.S631S|FES_uc010uqk.1_Silent_p.S741S|FES_uc002bpw.2_Intron|FES_uc010bny.2_Silent_p.S618S|FES_uc002bpx.2_Silent_p.S689S|FES_uc002bpy.2_Silent_p.S701S	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	759	Protein kinase.			S->F: Reduced autophosphorylation and strongly reduced kinase activity.	axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TGGGGGCCTCCCCCTATCCCA	0.607			NA											84	136					0	0	0.00361	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											3	7					0	0	0.000602	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr16:32890622T>G	uc002edh.1	-	5	440	c.264A>C	c.(262-264)AAA>AAC	p.K88N	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						CGTTGGTGTTTTTGTAGACCA	0.512			NA											3	23					0	0	0.004672	0	0
HYDIN	54768	broad.mit.edu	37	16	70972618	70972618	+	Silent	SNP	A	A	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr16:70972618A>T	uc002ezr.2	-	44	7019	c.6891T>A	c.(6889-6891)CGT>CGA	p.R2297R		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2298	Potential.									ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGTTTTGGAGACGCTCCTTCT	0.537			NA											13	17					0	0	0.003163	0	0
CBFA2T3	863	broad.mit.edu	37	16	88967957	88967957	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr16:88967957C>T	uc002fmm.1	-	2	445	c.259G>A	c.(259-261)GCA>ACA	p.A87T	CBFA2T3_uc002fml.1_Missense_Mutation_p.A26T|CBFA2T3_uc010cif.1_Missense_Mutation_p.A26T|CBFA2T3_uc002fmn.1_Missense_Mutation_p.A87T	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	87	Mediates localization to the nucleus (By similarity).|Pro-rich.|Mediates interaction with PDE7A (in isoform 2).|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CCCTGGGATGCGGCAGGCGGT	0.697			NA	T	RUNX1	AML								12	19					0	0	0.001855	0	0
FANCA	2175	broad.mit.edu	37	16	89858414	89858414	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr16:89858414C>A	uc002fou.1	-	13	1188	c.1146G>T	c.(1144-1146)CAG>CAT	p.Q382H	FANCA_uc010vpn.1_Missense_Mutation_p.Q382H	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	382					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		AGTGAACCTCCTGCGTTTCCA	0.517			NA	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				22	36					2.70639e-06	3.21729e-06	0.002299	1	0
MYH13	8735	broad.mit.edu	37	17	10212750	10212750	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr17:10212750G>A	uc002gmk.1	-	35	5060	c.4970C>T	c.(4969-4971)TCC>TTC	p.S1657F		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1657	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ATGCAGCTGGGAGTCCTGCAG	0.672			NA											3	9					0	0	0.004672	0	0
MYH4	4622	broad.mit.edu	37	17	10363356	10363356	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr17:10363356G>A	uc002gmn.2	-	14	1440	c.1329C>T	c.(1327-1329)GTC>GTT	p.V443V	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	443	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGATGCGGGTGACCATCCACA	0.473			NA											77	161					0	0	0.00361	0	0
KRT37	8688	broad.mit.edu	37	17	39579093	39579093	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr17:39579093G>T	uc002hwp.1	-	3	716	c.669C>A	c.(667-669)GAC>GAA	p.D223E	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	223	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GGGCCTCCAGGTCGGCCTTGG	0.667			NA											37	30					4.00102e-26	6.61161e-26	0.00623	1	0
C17orf71	55181	broad.mit.edu	37	17	57288786	57288786	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr17:57288786G>A	uc002ixi.2	+	1	1416	c.1374G>A	c.(1372-1374)GTG>GTA	p.V458V		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	458					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TGTATGAGGTGGCTATTGATG	0.433			NA											40	53					0	0	0.00874	0	0
MAP3K3	4215	broad.mit.edu	37	17	61769133	61769133	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr17:61769133C>A	uc002jbg.2	+	14	1704	c.1385C>A	c.(1384-1386)ACA>AAA	p.T462K	MAP3K3_uc002jbe.2_Missense_Mutation_p.T493K|MAP3K3_uc002jbf.2_Missense_Mutation_p.T493K|MAP3K3_uc002jbh.2_Missense_Mutation_p.T489K|MAP3K3_uc010wpo.1_Missense_Mutation_p.T377K|MAP3K3_uc010wpp.1_Missense_Mutation_p.T458K	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	462	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						GGTGCTCTGACAGAGAGCGTG	0.547			NA											40	157					1.32136e-16	1.93633e-16	0.00874	1	0
GGA3	23163	broad.mit.edu	37	17	73242605	73242605	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr17:73242605C>T	uc002jni.1	-	3	195	c.186G>A	c.(184-186)GCG>GCA	p.A62A	GGA3_uc002jnj.1_Silent_p.A62A|GGA3_uc010wrw.1_5'UTR|GGA3_uc002jnk.1_5'UTR|GGA3_uc010wrx.1_Intron|GGA3_uc010wry.1_5'UTR|GGA3_uc010wrz.1_Silent_p.A62A	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	62	VHS.|Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			GGGCCTGGAGCGCCTCCCATT	0.627			NA											7	30					0	0	0.001984	0	0
ZNF521	25925	broad.mit.edu	37	18	22804959	22804959	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr18:22804959T>C	uc002kvk.2	-	4	3170	c.2923A>G	c.(2923-2925)ACT>GCT	p.T975A	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.T975A|ZNF521_uc002kvl.2_Missense_Mutation_p.T755A	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	975	C2H2-type 23.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTGTGTTCAGTAAGAGTTAAA	0.483			NA	T	PAX5	ALL								41	78					0	0	0.002852	0	0
ASXL3	80816	broad.mit.edu	37	18	31226268	31226268	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr18:31226268G>T	uc010dmg.1	+	4	361	c.306G>T	c.(304-306)TTG>TTT	p.L102F	ASXL3_uc002kxq.2_5'UTR	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AATCTGAATTGGATGGTACAG	0.383			NA											26	189					2.12542e-12	2.91307e-12	0.00632	1	0
SMAD4	4089	broad.mit.edu	37	18	48581339	48581339	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr18:48581339C>T	uc010xdp.1	+	5	1181	c.643C>T	c.(643-645)CCC>TCC	p.P215S	SMAD4_uc010xdo.1_RNA|SMAD4_uc002lfb.3_Missense_Mutation_p.P60S	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	215					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(3)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TGCCAACTTTCCCAACATTCC	0.463			NA							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				49	37					0	0	0.00361	0	0
STK11	6794	broad.mit.edu	37	19	1220715	1220715	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:1220715C>T	uc002lrl.1	+	5	1848	c.733C>T	c.(733-735)CTC>TTC	p.L245F		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	245	Protein kinase.		L -> R (in sporadic cancer; somatic mutation; impairs heterotrimeric complex assembly with STRADA and CAB39).		anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(2)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGGTCACCCTGTAAGTGCC	0.706			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			17	9					0	0	0.001523	0	0
KHSRP	8570	broad.mit.edu	37	19	6420440	6420440	+	Silent	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:6420440C>A	uc002mer.3	-	5	578	c.468G>T	c.(466-468)GTG>GTT	p.V156V		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	156	Gly-rich.|KH 1.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						CACTCAGGCCCACCATGCCGT	0.592	Colon(55;593 1006 2067 9135 22980)		NA											12	10					1.5842e-08	1.9739e-08	0.001855	1	0
TNFSF14	8740	broad.mit.edu	37	19	6664944	6664944	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:6664944A>G	uc002mfk.1	-	5	1098	c.716T>C	c.(715-717)ATG>ACG	p.M239T	TNFSF14_uc002mfj.1_Missense_Mutation_p.M203T	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	239	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CCTTCACACCATGAAAGCCCC	0.552			NA											55	40					0	0	0.00361	0	0
ZNF560	147741	broad.mit.edu	37	19	9582050	9582050	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:9582050C>T	uc002mlp.1	-	6	453	c.243G>A	c.(241-243)TGG>TGA	p.W81*	ZNF560_uc010dwr.1_5'UTR	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	81	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GTTTTATTGCCCAGTCTGAAA	0.289			NA											28	17					0	0	0.005443	0	0
ZNF653	115950	broad.mit.edu	37	19	11594670	11594670	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:11594670C>G	uc002mrz.1	-	9	1728	c.1675G>C	c.(1675-1677)GAG>CAG	p.E559Q	ELAVL3_uc002mrx.1_5'Flank|ELAVL3_uc002mry.1_5'Flank	NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	559	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCACAGATCTCGCACCTGCCG	0.512	Pancreas(83;980 1446 4542 6441 43352)		NA											3	7					0	0	0.001168	0	0
ZNF442	79973	broad.mit.edu	37	19	12461745	12461745	+	Silent	SNP	A	A	G	rs117398535	byFrequency	TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:12461745A>G	uc002mtr.1	-	6	1265	c.654T>C	c.(652-654)TTT>TTC	p.F218F	ZNF442_uc010xmk.1_Silent_p.F149F	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	218	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						TAGGCCAAAAAAAGGCTTTCC	0.403			NA											5	107					0	0	0.000602	0	0
ZNF14	7561	broad.mit.edu	37	19	19824913	19824913	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:19824913C>A	uc002nnk.1	-	3	332	c.178G>T	c.(178-180)GGG>TGG	p.G60W		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	60	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				CGATTTTTCCCCTGGTTTCTG	0.363			NA											27	23					3.11337e-16	4.53385e-16	0.002836	1	0
ZNF43	7594	broad.mit.edu	37	19	22018896	22018896	+	Translation_Start_Site	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:22018896G>T	uc002nqj.2	-	1	75	c.-55C>A	c.(-57--53)ACCTG>ACATG		ZNF43_uc010ecv.2_Intron|ZNF43_uc002nql.2_Intron|ZNF43_uc002nqm.2_Intron|ZNF43_uc002nqk.2_Translation_Start_Site	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AATACCCGCAGGTCACAGAGC	0.622			NA											13	38					1.61879e-10	2.13095e-10	0.001368	1	0
SLC7A10	56301	broad.mit.edu	37	19	33699842	33699842	+	Silent	SNP	T	T	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:33699842T>G	uc002num.2	-	11	1674	c.1527A>C	c.(1525-1527)CCA>CCC	p.P509P	SLC7A10_uc002nul.2_Silent_p.P356P	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	509					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GCAGGGAGGGTGGGCAGGGGC	0.547			NA											5	17					0	0	0.000978	0	0
SPTBN4	57731	broad.mit.edu	37	19	41019317	41019317	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:41019317G>T	uc002ony.2	+	14	2707	c.2621G>T	c.(2620-2622)CGC>CTC	p.R874L	SPTBN4_uc002onx.2_Missense_Mutation_p.R874L|SPTBN4_uc002onz.2_Missense_Mutation_p.R874L|SPTBN4_uc010egx.2_5'UTR	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	874	Spectrin 6.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCGCTGAGGCGCCAGTGGCTG	0.667			NA											6	5					0.00198382	0.00226583	0.001984	1	0
SIGLEC9	27180	broad.mit.edu	37	19	51630302	51630302	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:51630302G>T	uc002pvu.2	+	4	831	c.764G>T	c.(763-765)GGA>GTA	p.G255V	SIGLEC9_uc010yct.1_Missense_Mutation_p.G255V	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	255	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ACAGTCTTGGGAAATGGCTCA	0.343			NA											22	70					5.26018e-13	7.29537e-13	0.001882	1	0
SIGLEC14	100049587	broad.mit.edu	37	19	52146834	52146834	+	Silent	SNP	A	A	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:52146834A>C	uc002pxf.3	-	6	1224	c.1104T>G	c.(1102-1104)GCT>GCG	p.A368A		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	368	Helical; (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		GGAGGAAGCCAGCCCCCATGA	0.597			NA											26	40					0	0	0.004656	0	0
ZNF816A	125893	broad.mit.edu	37	19	53459279	53459280	+	Splice_Site	DNP	CC	CC	AA			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:53459279_53459280CC>AA	uc002qal.1	-	3	364	c.63_splice	c.e3+1	p.Q21_splice	ZNF321_uc010eqj.2_Splice_Site_p.Q5_splice|ZNF321_uc002qak.1_Splice_Site_p.Q5_splice|ZNF816A_uc002qam.1_Splice_Site_p.Q5_splice	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		ATATCACTTACCTGAGGAAGAG	0.431			NA											36	71					0	0	0.004672	0	0
VN1R4	317703	broad.mit.edu	37	19	53770108	53770108	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:53770108C>A	uc010ydu.1	-	1	811	c.811G>T	c.(811-813)GCC>TCC	p.A271S		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	271	Helical; Name=7; (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		CTCATTAAGGCTGAAGTGTTC	0.438			NA								HNSCC(26;0.072)			23	40					3.83957e-06	4.54122e-06	0.00278	1	0
LILRB4	11006	broad.mit.edu	37	19	55175722	55175722	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:55175722G>A	uc002qgp.2	+	4	803	c.441G>A	c.(439-441)CGG>CGA	p.R147R	LILRB4_uc002qgq.2_Silent_p.R147R|LILRB4_uc010ers.1_Silent_p.R60R|LILRB4_uc002qgr.2_Silent_p.R188R|LILRB4_uc010ert.2_Silent_p.R188R|LILRB4_uc010eru.2_Silent_p.R176R	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	147	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		GTCAGTCACGGAGCCCAATGG	0.572			NA											36	71					0	0	0.003271	0	0
NLRP7	199713	broad.mit.edu	37	19	55453058	55453058	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:55453058A>T	uc002qih.3	-	2	98	c.22T>A	c.(22-24)TGG>AGG	p.W8R	NLRP7_uc002qig.3_Missense_Mutation_p.W8R|NLRP7_uc002qii.3_Missense_Mutation_p.W8R|NLRP7_uc010esk.2_Missense_Mutation_p.W8R|NLRP7_uc010esl.2_Missense_Mutation_p.W36R	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	8	DAPIN.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TGCAGAGTCCACTCTAGCTGG	0.478			NA											18	23					0	0	0.007413	0	0
GP6	51206	broad.mit.edu	37	19	55543711	55543711	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:55543711C>A	uc002qik.2	-	3	149	c.121G>T	c.(121-123)GAG>TAG	p.E41*	GP6_uc002qil.2_Nonsense_Mutation_p.E41*|GP6_uc010esq.2_Nonsense_Mutation_p.E41*|RDH13_uc010esr.1_Intron	NM_016363	NP_057447	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet) isoform 2	41	Ig-like C2-type 1.|Extracellular (Potential).				enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		ACTGGCTTCTCCAGGGGCACC	0.682			NA											17	14					9.16793e-09	1.14846e-08	0.00499	1	0
KLF11	8462	broad.mit.edu	37	2	10186425	10186425	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:10186425G>A	uc002raf.1	+	2	353	c.191G>A	c.(190-192)GGT>GAT	p.G64D	KLF11_uc010yjc.1_Missense_Mutation_p.G47D	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	64					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		TCCCAGAAAGGTGACCTGTTG	0.527	Melanoma(56;431 1507 23687 50789)		NA											17	24					0	0	0.006122	0	0
XDH	7498	broad.mit.edu	37	2	31602826	31602826	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:31602826G>A	uc002rnv.1	-	13	1228	c.1149C>T	c.(1147-1149)GTC>GTT	p.V383V		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	383	FAD-binding PCMH-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GGTCCATCTGGACAGTTCTCC	0.552	Colon(66;682 1445 30109 40147)		NA											36	51					0	0	0.00623	0	0
DHX57	90957	broad.mit.edu	37	2	39088534	39088534	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:39088534C>A	uc002rrf.2	-	5	1117	c.1018G>T	c.(1018-1020)GAT>TAT	p.D340Y	DHX57_uc002rre.2_5'UTR|DHX57_uc002rrg.2_Missense_Mutation_p.D340Y	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	340							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				AGATGAGAATCATCTACACTT	0.343	Melanoma(191;1090 2095 4375 23729 47341)		NA											14	28					9.31168e-06	1.07941e-05	0.001855	1	0
EHBP1	23301	broad.mit.edu	37	2	62974575	62974575	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:62974575G>A	uc002sby.2	+	3	632	c.150G>A	c.(148-150)AGG>AGA	p.R50R	EHBP1_uc010fcp.2_Silent_p.R50R|EHBP1_uc010fcq.1_Silent_p.R50R|EHBP1_uc002sbx.2_Silent_p.R50R|EHBP1_uc002sbz.2_Silent_p.R50R|EHBP1_uc002scb.2_Silent_p.R50R|EHBP1_uc002sca.2_Silent_p.R50R	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	50						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GAAGCCGAAGGAAGTCTTCTA	0.299			NA							Hereditary_Prostate_Cancer				18	83					0	0	0.001523	0	0
REG3G	130120	broad.mit.edu	37	2	79255050	79255050	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:79255050A>G	uc002snw.2	+	5	536	c.451A>G	c.(451-453)AGA>GGA	p.R151G	REG3G_uc002snx.2_Missense_Mutation_p.R151G|REG3G_uc010ffu.2_Missense_Mutation_p.R105G	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	151	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						GAGCCTGTCAAGAAGCACAGG	0.478			NA											37	47					0	0	0.006999	0	0
CNGA3	1261	broad.mit.edu	37	2	99012950	99012950	+	Silent	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:99012950G>T	uc002syt.2	+	8	1734	c.1317G>T	c.(1315-1317)CGG>CGT	p.R439R	CNGA3_uc002syu.2_Silent_p.R421R|CNGA3_uc010fij.2_Silent_p.R443R	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	439			R -> W (in ACHM2; does not reveal any detectable calcium influx upon agonist application at 37 degrees Celsius; the channel function could be restored by incubating the transfected cells at 27 degrees Celsius; the dose-response relationship for cGMP-activation is shifted toward a lower cGMP concentration; the dose-response relationship of the mutant CNGA3 + CNGB3 is similar to that of the wild-type protein; coexpression of the CNGB3 subunit compensate completely for the slightly higher apparent cGMP sensitivity of homomers; the channel density into the cell membrane is considerably improved by decreasing the cultivation temparature).		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GGGTTATCCGGTGGTTTGACT	0.547			NA											16	32					1.3612e-06	1.64332e-06	0.003163	1	0
TGFBRAP1	9392	broad.mit.edu	37	2	105897176	105897176	+	Missense_Mutation	SNP	C	C	A	rs56016004	by1000genomes	TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:105897176C>A	uc002tcq.2	-	6	1210	c.1126G>T	c.(1126-1128)GGC>TGC	p.G376C	TGFBRAP1_uc010fjc.2_Missense_Mutation_p.G146C|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.G376C	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	376					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						TCAAGCTGGCCGCTTCTGCAA	0.542	Esophageal Squamous(183;794 2019 9730 21801 48859)		NA											8	14					5.18039e-06	6.03516e-06	0.00308	1	0
KCNJ3	3760	broad.mit.edu	37	2	155711687	155711687	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:155711687C>T	uc002tyv.1	+	3	1563	c.1368C>T	c.(1366-1368)ACC>ACT	p.T456T	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	456	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	CTAAAACCACCAAGATGTTAT	0.468			NA											30	37					0	0	0.008361	0	0
CPS1	1373	broad.mit.edu	37	2	211503873	211503873	+	Splice_Site	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:211503873G>T	uc002vee.3	+	23	2962	c.2830_splice	c.e23-1	p.I944_splice	CPS1_uc010fur.2_Splice_Site_p.I950_splice|CPS1_uc010fus.2_Splice_Site_p.I493_splice	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b						carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCTCTTACAGATTGATACAC	0.303			NA											10	18					1.58986e-06	1.90948e-06	0.008291	1	0
SIRPG	55423	broad.mit.edu	37	20	1617082	1617082	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr20:1617082G>T	uc002wfm.1	-	3	565	c.500C>A	c.(499-501)ACC>AAC	p.T167N	SIRPG_uc002wfn.1_Missense_Mutation_p.T167N|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	167	Extracellular (Potential).|Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						GGACTCACAGGTGAAACTCAC	0.542			NA											41	81					2.66277e-13	3.71512e-13	0.006999	1	0
SEMG1	6406	broad.mit.edu	37	20	43837137	43837137	+	Missense_Mutation	SNP	G	G	C	rs147894843		TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr20:43837137G>C	uc002xni.2	+	2	1256	c.1199G>C	c.(1198-1200)GGT>GCT	p.G400A	SEMG1_uc002xnj.2_Missense_Mutation_p.G340A|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.G340A	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	400					insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CCATGGCATGGTGAAAATGCA	0.438			NA											35	34					0	0	0.002445	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874354	31874354	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr21:31874354C>A	uc011ada.1	-	1	55	c.55G>T	c.(55-57)GAT>TAT	p.D19Y		NM_181611	NP_853642	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	19						intermediate filament	protein binding				0						CCCAGGTCATCGAAGCCTCCG	0.587			NA											47	69					1.61863e-15	2.32803e-15	0.00361	1	0
UMODL1	89766	broad.mit.edu	37	21	43491428	43491428	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr21:43491428G>A	uc002zaf.1	+	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I	UMODL1_uc002zad.1_Intron|UMODL1_uc002zae.1_Intron|UMODL1_uc002zag.1_Missense_Mutation_p.M1I	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	1						cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						GCCGGACGATGCTCAGGACCT	0.662	Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)		NA											6	10					0	0	0.001168	0	0
PHF21B	112885	broad.mit.edu	37	22	45309877	45309877	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr22:45309877G>T	uc003bfn.2	-	5	807	c.656C>A	c.(655-657)TCA>TAA	p.S219*	PHF21B_uc003bfm.2_Intron|PHF21B_uc011aqk.1_Intron|PHF21B_uc011aql.1_Intron|PHF21B_uc011aqm.1_Intron	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	219							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		aggggacagtgatggggaggg	0.244			NA											24	30					1.10923e-09	1.42006e-09	0.00278	1	0
SAPS2	9701	broad.mit.edu	37	22	50832508	50832508	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr22:50832508G>A	uc003blb.1	+	4	593	c.171G>A	c.(169-171)CTG>CTA	p.L57L	SAPS2_uc003bky.1_Silent_p.L57L|SAPS2_uc003bkz.1_Silent_p.L57L|SAPS2_uc003blc.2_Silent_p.L57L|SAPS2_uc003bla.1_Silent_p.L57L	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	57						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		TGGAGGAGCTGGTGAGCCTCA	0.557			NA											22	111					0	0	0.002299	0	0
SLC4A7	9497	broad.mit.edu	37	3	27442272	27442272	+	Nonsense_Mutation	SNP	T	T	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:27442272T>A	uc003cdv.2	-	16	2454	c.2383A>T	c.(2383-2385)AGA>TGA	p.R795*	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Nonsense_Mutation_p.R676*|SLC4A7_uc011aww.1_Nonsense_Mutation_p.R804*|SLC4A7_uc011awx.1_Nonsense_Mutation_p.R791*|SLC4A7_uc011awy.1_Nonsense_Mutation_p.R787*|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Nonsense_Mutation_p.R676*|SLC4A7_uc011axb.1_Nonsense_Mutation_p.R791*|SLC4A7_uc010hfl.2_Nonsense_Mutation_p.R345*|SLC4A7_uc003cdw.2_Nonsense_Mutation_p.R671*	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	795	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						GTAAGATTTCTCCAGGAAATA	0.328			NA											52	49					0	0	0.00361	0	0
DHX30	22907	broad.mit.edu	37	3	47887703	47887703	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:47887703G>A	uc003cru.2	+	11	1567	c.1141G>A	c.(1141-1143)GAT>AAT	p.D381N	DHX30_uc003crt.2_Missense_Mutation_p.D342N	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	381						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GCTGCAGAGTGATGACATCTT	0.542			NA											28	126					0	0	0.004656	0	0
DHX30	22907	broad.mit.edu	37	3	47887817	47887817	+	Missense_Mutation	SNP	G	G	C	rs71328953		TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:47887817G>C	uc003cru.2	+	11	1681	c.1255G>C	c.(1255-1257)GAA>CAA	p.E419Q	DHX30_uc003crt.2_Missense_Mutation_p.E380Q	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	419						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GAGTCTGCTAGAACTGTGGCG	0.632			NA											23	86					0	0	0.00278	0	0
DHX30	22907	broad.mit.edu	37	3	47887871	47887871	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:47887871G>A	uc003cru.2	+	11	1735	c.1309G>A	c.(1309-1311)GAC>AAC	p.D437N	DHX30_uc003crt.2_Missense_Mutation_p.D398N	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	437						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GCTACCTGTGGACCCACATCG	0.657			NA											13	60					0	0	0.00245	0	0
FLNB	2317	broad.mit.edu	37	3	58140628	58140628	+	Missense_Mutation	SNP	G	G	T	rs144963323		TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:58140628G>T	uc003djj.2	+	40	6910	c.6745G>T	c.(6745-6747)GGT>TGT	p.G2249C	FLNB_uc010hne.2_Missense_Mutation_p.G2280C|FLNB_uc003djk.2_Missense_Mutation_p.G2238C|FLNB_uc010hnf.2_Missense_Mutation_p.G2225C|FLNB_uc003djl.2_Missense_Mutation_p.G2069C|FLNB_uc003djm.2_Missense_Mutation_p.G2056C	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2249	Interaction with INPPL1.|Filamin 21.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TGGGTCGTGCGGTGTATCTTA	0.438			NA											22	34					5.35356e-11	7.16884e-11	0.00278	1	0
FOXP1	27086	broad.mit.edu	37	3	71027060	71027060	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:71027060C>A	uc003dol.2	-	11	1590	c.1267G>T	c.(1267-1269)GTC>TTC	p.V423F	FOXP1_uc003dom.2_Missense_Mutation_p.V347F|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.V423F|FOXP1_uc003dop.2_Missense_Mutation_p.V423F|FOXP1_uc003doq.1_Missense_Mutation_p.V422F|FOXP1_uc003doi.2_Missense_Mutation_p.V323F|FOXP1_uc003doj.2_Missense_Mutation_p.V323F|FOXP1_uc003dok.2_Missense_Mutation_p.V236F|FOXP1_uc003dor.1_Missense_Mutation_p.V201F	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	423					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GTTGTGATGACAGAGGGGCCT	0.577			NA	T	PAX5	ALL								23	74					2.21704e-12	3.02087e-12	0.00278	1	0
FAM86D	692099	broad.mit.edu	37	3	75475685	75475685	+	Missense_Mutation	SNP	A	A	G	rs11128433	by1000genomes	TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:75475685A>G	uc003dpp.3	-	7	912	c.553T>C	c.(553-555)TGG>CGG	p.W185R	FAM86D_uc003dpo.3_RNA|FAM86D_uc003dps.3_RNA|FAM86D_uc003dpq.3_Missense_Mutation_p.W93R|FAM86D_uc003dpr.3_RNA	NR_024241				RecName: Full=Protein FAM86B1;												0						TGGTGCTCCCAGCAGGCAGCC	0.602			NA											3	48					0	0	0.000602	0	0
ROBO1	6091	broad.mit.edu	37	3	78685076	78685076	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:78685076C>A	uc003dqe.2	-	23	3428	c.3220G>T	c.(3220-3222)GCC>TCC	p.A1074S	ROBO1_uc003dqb.2_Missense_Mutation_p.A1035S|ROBO1_uc003dqc.2_Missense_Mutation_p.A974S|ROBO1_uc003dqd.2_Missense_Mutation_p.A1029S|ROBO1_uc010hoh.2_Missense_Mutation_p.A266S|ROBO1_uc011bgl.1_Missense_Mutation_p.A646S	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1074	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGAGTGGTGGCGTAAGGAGTA	0.488			NA											18	69					3.62473e-10	4.66609e-10	0.001882	1	0
ZMAT3	64393	broad.mit.edu	37	3	178785396	178785396	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:178785396C>T	uc003fjg.2	-	2	404	c.145G>A	c.(145-147)GGG>AGG	p.G49R	ZMAT3_uc010hxa.2_Missense_Mutation_p.G49R|ZMAT3_uc003fji.2_Missense_Mutation_p.G49R	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1	49					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			TCTTCTTCCCCTGCAAGAGGC	0.557			NA											39	26					0	0	0.004289	0	0
C4orf42	92070	broad.mit.edu	37	4	1244578	1244578	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr4:1244578A>G	uc003gcz.1	+	1	402	c.217A>G	c.(217-219)ACT>GCT	p.T73A	CTBP1_uc003gcu.1_5'Flank|CTBP1_uc003gcv.1_5'Flank|C4orf42_uc003gcy.1_RNA	NM_052861	NP_443093			hypothetical protein LOC92070											ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0101)	Colorectal(103;0.188)		TAATGGAGAGACTTCTGGGGA	0.562			NA											23	30					0	0	0.002299	0	0
RHOH	399	broad.mit.edu	37	4	40245368	40245368	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr4:40245368G>T	uc003guz.2	+	3	1086	c.362G>T	c.(361-363)CGG>CTG	p.R121L		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	121					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						ACTGACCAGCGGGAGATGGGG	0.567			NA											8	23					5.18039e-06	6.03516e-06	0.00308	1	0
TECRL	253017	broad.mit.edu	37	4	65188467	65188467	+	Silent	SNP	T	T	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr4:65188467T>A	uc003hcv.2	-	4	484	c.375A>T	c.(373-375)GCA>GCT	p.A125A	TECRL_uc003hcw.2_Silent_p.A125A	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	125					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TGGAGGAAGCTGCAATACTTT	0.308			NA											7	25					0	0	0.00308	0	0
CXCL1	2919	broad.mit.edu	37	4	74735447	74735447	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr4:74735447C>T	uc003hhh.1	+	2	241	c.162C>T	c.(160-162)CCC>CCT	p.P54P		NM_001511	NP_001502	P09341	GROA_HUMAN	chemokine (C-X-C motif) ligand 1	54					actin cytoskeleton organization|cell proliferation|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GAATTCACCCCAAGAACATCC	0.627			NA											31	61					0	0	0.008361	0	0
SNCA	6622	broad.mit.edu	37	4	90756779	90756779	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr4:90756779C>T	uc003hsq.2	-	2	299	c.40G>A	c.(40-42)GGA>AGA	p.G14R	SNCA_uc010ikt.2_Missense_Mutation_p.G14R|SNCA_uc003hso.2_Missense_Mutation_p.G14R|SNCA_uc003hsp.2_Missense_Mutation_p.G14R|SNCA_uc003hsr.2_Missense_Mutation_p.G14R|uc003hss.1_5'Flank	NM_001146054	NP_001139526	P37840	SYUA_HUMAN	alpha-synuclein isoform NACP140	14					activation of caspase activity|anti-apoptosis|negative regulation of dopamine uptake|negative regulation of exocytosis|negative regulation of histone acetylation|negative regulation of microtubule polymerization|negative regulation of monooxygenase activity|negative regulation of norepinephrine uptake|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of serotonin uptake|negative regulation of thrombin receptor signaling pathway|negative regulation of transporter activity|positive regulation of endocytosis|positive regulation of inositol phosphate biosynthetic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein serine/threonine kinase activity|positive regulation of receptor recycling|positive regulation of release of sequestered calcium ion into cytosol|receptor internalization|regulation of phospholipase activity|response to interferon-gamma|response to interleukin-1|response to iron(II) ion|response to lipopolysaccharide|response to magnesium ion|synaptic vesicle endocytosis	actin cytoskeleton|axon|cell cortex|cell junction|cytosol|fibril|growth cone|nucleus|synapse	alpha-tubulin binding|calcium ion binding|caspase inhibitor activity|dynein binding|ferrous iron binding|histone binding|Hsp70 protein binding|kinesin binding|magnesium ion binding|phosphoprotein binding|tau protein binding|zinc ion binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.42e-05)	Melatonin(DB01065)	GCCACAACTCCCTCCTTGGCC	0.423			NA											17	43					0	0	0.00499	0	0
TLL1	7092	broad.mit.edu	37	4	166935588	166935588	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr4:166935588G>T	uc003irh.1	+	8	1565	c.918G>T	c.(916-918)AGG>AGT	p.R306S	TLL1_uc011cjn.1_Missense_Mutation_p.R306S|TLL1_uc011cjo.1_Missense_Mutation_p.R130S	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	306	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TTTTTTTCAGGGGGATGTTTC	0.413			NA											29	116					2.2171e-23	3.51418e-23	0.001786	1	0
SDHA	6389	broad.mit.edu	37	5	256470	256470	+	Missense_Mutation	SNP	G	G	T	rs3211483		TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:256470G>T	uc003jao.3	+	15	2045	c.1930G>T	c.(1930-1932)GTG>TTG	p.V644L	SDHA_uc011clw.1_Missense_Mutation_p.V596L|SDHA_uc003jap.3_Missense_Mutation_p.V563L|SDHA_uc003jaq.3_Missense_Mutation_p.V419L|SDHA_uc003jar.3_Missense_Mutation_p.V238L	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	644					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	ATATAGACCCGTGATCGACAA	0.428			NA							Familial_Paragangliomas				7	101					0.00307968	0.00350032	0.00308	1	0
DNAH5	1767	broad.mit.edu	37	5	13864539	13864539	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:13864539C>A	uc003jfd.2	-	28	4605	c.4563G>T	c.(4561-4563)GAG>GAT	p.E1521D		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1521	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAAGAGGTGCCTCCATGATAT	0.408			NA							Kartagener_syndrome				27	33					2.79863e-10	3.62267e-10	0.004656	1	0
PRDM9	56979	broad.mit.edu	37	5	23522875	23522875	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:23522875C>A	uc003jgo.2	+	8	945	c.763C>A	c.(763-765)CAG>AAG	p.Q255K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	255	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGGCATCCCTCAGGCTGGGCT	0.572			NA								HNSCC(3;0.000094)			19	31					2.37509e-13	3.33371e-13	0.001523	1	0
AFF4	27125	broad.mit.edu	37	5	132232907	132232907	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:132232907C>A	uc003kyd.2	-	11	1823	c.1415G>T	c.(1414-1416)TGG>TTG	p.W472L	AFF4_uc011cxk.1_Missense_Mutation_p.W150L|AFF4_uc003kye.1_Missense_Mutation_p.W472L	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	472					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATCAAGTTGCCATTTGTTTGT	0.413	Ovarian(126;889 1733 2942 10745 11605)		NA											29	105					3.80469e-20	5.71931e-20	0.001786	1	0
PCDHA10	56139	broad.mit.edu	37	5	140237891	140237891	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:140237891G>A	uc003lhx.2	+	1	2258	c.2258G>A	c.(2257-2259)CGG>CAG	p.R753Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.R753Q	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	753	6 X 4 AA repeats of P-X-X-P.|Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAGAGGCGGCAGAGGGTG	0.672			NA											14	12					0	0	0.00245	0	0
PCDHB9	56127	broad.mit.edu	37	5	140568980	140568980	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:140568980G>T	uc003liw.1	+	3	2089	c.2089G>T	c.(2089-2091)GTG>TTG	p.V697L	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	697	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTGGCCTCGGTGTCTTCGCT	0.716			NA											25	159					3.21987e-24	5.174e-24	0.00361	1	0
PCDHB10	56126	broad.mit.edu	37	5	140574220	140574220	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:140574220G>T	uc003lix.2	+	1	2269	c.2095G>T	c.(2095-2097)GTG>TTG	p.V699L		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	699	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTGGCCTCGGTGTCTTCGCT	0.716			NA											21	62					3.86903e-22	6.05023e-22	0.002836	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755487	140755487	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:140755487G>T	uc003ljy.1	+	1	1837	c.1837G>T	c.(1837-1839)GAG>TAG	p.E613*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Nonsense_Mutation_p.E613*	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	613	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGGCCAGCGAGCCAGGACT	0.687			NA											28	34					8.58068e-18	1.26538e-17	0.007291	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140798727	140798727	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:140798727C>T	uc003lkn.1	+	1	1446	c.1301C>T	c.(1300-1302)TCC>TTC	p.S434F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.S434F|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	434	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGTTATCCTCCAGCAAAACC	0.552			NA											5	41					0	0	0.001168	0	0
FAT2	2196	broad.mit.edu	37	5	150911504	150911504	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:150911504A>C	uc003lue.3	-	13	9468	c.9455T>G	c.(9454-9456)CTG>CGG	p.L3152R	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_5'UTR	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3152	Extracellular (Potential).|Cadherin 28.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAATCCGGCAGAGAGTAAAC	0.642			NA											16	50					0	0	0.00499	0	0
SOX30	11063	broad.mit.edu	37	5	157078524	157078524	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:157078524G>T	uc003lxb.1	-	1	905	c.563C>A	c.(562-564)GCG>GAG	p.A188E	SOX30_uc003lxc.1_Missense_Mutation_p.A188E|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	188					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GACCTCCTCCGCCTCCAGCTT	0.642	Esophageal Squamous(31;525 799 19355 21125 41744)		NA											77	50					3.76054e-38	6.58801e-38	0.00361	1	0
GABRA6	2559	broad.mit.edu	37	5	161116287	161116287	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:161116287G>T	uc003lyu.2	+	5	812	c.474G>T	c.(472-474)ATG>ATT	p.M158I	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	158	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACTGTCCCATGAGGCTGGTTA	0.408			NA								TCGA Ovarian(5;0.080)			40	39					2.35958e-20	3.59335e-20	0.002222	1	0
BOD1	91272	broad.mit.edu	37	5	173036425	173036425	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:173036425C>A	uc003mcq.2	-	3	602	c.375G>T	c.(373-375)TTG>TTT	p.L125F	BOD1_uc003mcr.2_Intron	NM_138369	NP_612378	Q96IK1	BOD1_HUMAN	biorientation of chromosomes in cell division 1	125					cell division|mitosis	condensed chromosome kinetochore|microtubule organizing center				ovary(2)	2						CTCCAGCTTCCAACATCCCTG	0.448			NA											23	102					1.96895e-08	2.44024e-08	0.00278	1	0
SNCB	6620	broad.mit.edu	37	5	176056582	176056582	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:176056582C>A	uc003mep.2	-	3	517	c.74G>T	c.(73-75)GGG>GTG	p.G25V	SNCB_uc003meq.2_Missense_Mutation_p.G25V|SNCB_uc010jke.1_Missense_Mutation_p.G25V|hsa-mir-4281|MI0015885_5'Flank|EIF4E1B_uc010jkf.1_5'Flank	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	25	1.|4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCGGTGACCCCCTGCTTGGT	0.672			NA											7	14					0.00448238	0.00506988	0.004482	1	0
HK3	3101	broad.mit.edu	37	5	176309050	176309050	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:176309050A>T	uc003mfa.2	-	16	2224	c.2132T>A	c.(2131-2133)ATC>AAC	p.I711N	HK3_uc003mez.2_Missense_Mutation_p.I267N	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	711	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCCATGTTGATGCACATGCG	0.627			NA											36	35					0	0	0.003271	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178634557	178634557	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr5:178634557C>A	uc003mjw.2	-	4	848	c.848G>T	c.(847-849)GGG>GTG	p.G283V	ADAMTS2_uc011dgm.1_Missense_Mutation_p.G283V	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	283	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GTGCTCCTTCCCGTGGAACTG	0.632			NA											45	61					1.21353e-23	1.93667e-23	0.00361	1	0
HIST1H3B	8358	broad.mit.edu	37	6	26032019	26032019	+	Silent	SNP	C	C	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr6:26032019C>T	uc003nfs.1	-	1	270	c.270G>A	c.(268-270)GTG>GTA	p.V90V		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	90					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						GCAGCGCCATCACCGCAGAGC	0.557			NA											21	70					0	0	0.001882	0	0
GCM1	8521	broad.mit.edu	37	6	52993452	52993452	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr6:52993452T>A	uc003pbp.2	-	6	1072	c.863A>T	c.(862-864)TAC>TTC	p.Y288F		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	288						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					ATGATCAGAGTAGACTCCGGA	0.473			NA											21	36					0	0	0.001523	0	0
PRIM2	5558	broad.mit.edu	37	6	57512612	57512612	+	Silent	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr6:57512612C>A	uc003pdx.2	+	15	1527	c.1440C>A	c.(1438-1440)ACC>ACA	p.T480T		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	480					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TCCAGAAAACCAAGGATGCAT	0.403			NA											63	317					3.86002e-21	5.917e-21	0.00361	1	0
TTK	7272	broad.mit.edu	37	6	80715587	80715587	+	Silent	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr6:80715587A>G	uc003pjc.2	+	2	101	c.27A>G	c.(25-27)AGA>AGG	p.R9R	TTK_uc003pjb.3_Silent_p.R9R	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	9					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TAAGTGGCAGAGAATTGACAA	0.299			NA											15	14					0	0	0.003163	0	0
RFX6	222546	broad.mit.edu	37	6	117248302	117248302	+	Silent	SNP	A	A	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr6:117248302A>C	uc003pxm.2	+	17	2061	c.1998A>C	c.(1996-1998)CCA>CCC	p.P666P		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	666					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GGAGGCCCCCAAGTGTGGGCC	0.522			NA											59	42					0	0	0.00361	0	0
TXLNB	167838	broad.mit.edu	37	6	139591688	139591688	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr6:139591688C>A	uc011eds.1	-	4	757	c.592G>T	c.(592-594)GAC>TAC	p.D198Y		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	198	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TGTAACTGGTCCTTTTCTTTT	0.443			NA											28	18					8.24728e-16	1.19355e-15	0.004656	1	0
C6orf70	55780	broad.mit.edu	37	6	170169675	170169675	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr6:170169675C>G	uc003qxg.1	+	12	1132	c.1099C>G	c.(1099-1101)CGC>GGC	p.R367G	C6orf70_uc011ehb.1_Missense_Mutation_p.R241G|C6orf70_uc003qxh.1_Missense_Mutation_p.R367G|C6orf70_uc010kky.1_Missense_Mutation_p.R241G|C6orf70_uc003qxi.1_Missense_Mutation_p.R15G	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	367						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		GGAGGGTCCCCGCATAAGAGA	0.408			NA											12	6					0	0	0.001368	0	0
HOXA13	3209	broad.mit.edu	37	7	27238817	27238817	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:27238817C>A	uc003szb.1	-	1	909	c.880G>T	c.(880-882)GAG>TAG	p.E294*	uc003szc.1_5'Flank	NM_000522	NP_000513	P31271	HXA13_HUMAN	homeobox A13	294					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)	1						TGCGCCTGCTCTTTGGGGCAG	0.637			NA	T	NUP98	AML								15	31					4.7546e-09	6.02078e-09	0.004007	1	0
INMT	11185	broad.mit.edu	37	7	30793497	30793497	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:30793497C>A	uc003tbs.1	+	2	321	c.305C>A	c.(304-306)CCG>CAG	p.P102Q	FAM188B_uc010kwe.2_5'UTR|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Missense_Mutation_p.P101Q	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	102						cytoplasm	amine N-methyltransferase activity				0						AAGAAGGAGCCGGGGGCCTAT	0.572			NA											56	93					1.39843e-22	2.20158e-22	0.00361	1	0
CAMK2B	816	broad.mit.edu	37	7	44283039	44283039	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:44283039G>T	uc003tkq.2	-	7	712	c.502C>A	c.(502-504)CAG>AAG	p.Q168K	CAMK2B_uc003tkp.2_Missense_Mutation_p.Q168K|CAMK2B_uc003tkx.2_Missense_Mutation_p.Q168K|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.Q168K|CAMK2B_uc003tks.2_Missense_Mutation_p.Q168K|CAMK2B_uc003tku.2_Missense_Mutation_p.Q168K|CAMK2B_uc003tkv.2_Missense_Mutation_p.Q168K|CAMK2B_uc003tkt.2_Missense_Mutation_p.Q168K|CAMK2B_uc003tkw.2_Missense_Mutation_p.Q168K|CAMK2B_uc010kyc.2_Missense_Mutation_p.Q168K	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	168	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CATGCCTGCTGGTCCCCCTGC	0.632			NA											20	51					1.33834e-09	1.704e-09	0.007413	1	0
MYO1G	64005	broad.mit.edu	37	7	45010484	45010484	+	Nonsense_Mutation	SNP	T	T	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:45010484T>A	uc003tmh.2	-	8	1165	c.1021A>T	c.(1021-1023)AAG>TAG	p.K341*	MYO1G_uc003tmf.2_5'Flank|MYO1G_uc003tmg.2_Nonsense_Mutation_p.K103*|MYO1G_uc010kym.2_Nonsense_Mutation_p.K226*|MYO1G_uc003tmi.1_Nonsense_Mutation_p.K253*|MYO1G_uc003tmj.2_Nonsense_Mutation_p.K103*	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	341	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GTGTGGCCCTTCTCTATGAGT	0.662			NA											12	28					0	0	0.001855	0	0
ASNS	440	broad.mit.edu	37	7	97488526	97488526	+	Silent	SNP	T	T	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:97488526T>G	uc003uot.3	-	5	1178	c.672A>C	c.(670-672)CCA>CCC	p.P224P	ASNS_uc011kin.1_Silent_p.P141P|ASNS_uc003uou.3_Silent_p.P224P|ASNS_uc003uov.3_Silent_p.P224P|ASNS_uc011kio.1_Silent_p.P203P|ASNS_uc003uow.3_Silent_p.P203P|ASNS_uc003uox.3_Silent_p.P141P	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	224	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTCTGCTACCTGGAAAGAGTT	0.433	Melanoma(70;6 1280 3108 3799 51123)|GBM(6;275 291 425 9929 27738)		NA											11	64					0	0	0.001855	0	0
MUC17	140453	broad.mit.edu	37	7	100676675	100676675	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:100676675G>T	uc003uxp.1	+	3	2031	c.1978G>T	c.(1978-1980)GTG>TTG	p.V660L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	660	Extracellular (Potential).|9.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACACTCCTGTGACCACTTC	0.468			NA											106	491					4.10028e-47	7.34896e-47	0.00361	1	0
LAMB1	3912	broad.mit.edu	37	7	107615715	107615715	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:107615715A>G	uc003vew.2	-	11	1668	c.1333T>C	c.(1333-1335)TAT>CAT	p.Y445H	LAMB1_uc003vev.2_Missense_Mutation_p.Y469H|LAMB1_uc003vex.2_Missense_Mutation_p.Y445H|LAMB1_uc010ljn.1_Missense_Mutation_p.Y531H	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	445	Laminin EGF-like 3.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTAAATCATAGAAGCCTTCT	0.363			NA											36	58					0	0	0.002522	0	0
FAM3C	10447	broad.mit.edu	37	7	120991230	120991230	+	Silent	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:120991230C>A	uc003vjx.2	-	9	809	c.561G>T	c.(559-561)GGG>GGT	p.G187G	FAM3C_uc010lkm.2_Silent_p.G187G	NM_014888	NP_055703	Q92520	FAM3C_HUMAN	family with sequence similarity 3, member C	187					multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity				0	all_neural(327;0.117)					TAATGCCCTTCCCACCACAGA	0.418			NA											26	64					2.16457e-27	3.60247e-27	0.008361	1	0
FAM3C	10447	broad.mit.edu	37	7	120991242	120991242	+	Silent	SNP	G	G	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:120991242G>C	uc003vjx.2	-	9	797	c.549C>G	c.(547-549)GTC>GTG	p.V183V	FAM3C_uc010lkm.2_Silent_p.V183V	NM_014888	NP_055703	Q92520	FAM3C_HUMAN	family with sequence similarity 3, member C	183					multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity				0	all_neural(327;0.117)					CACCACAGAAGACCCAGTTGT	0.428			NA											24	60					0	0	0.00278	0	0
GRM8	2918	broad.mit.edu	37	7	126746607	126746607	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:126746607C>G	uc003vlr.2	-	2	981	c.670G>C	c.(670-672)GAG>CAG	p.E224Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.E224Q|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_5'UTR	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	224	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TAGTTCCCCTCAGAAGCCAGT	0.498			NA								HNSCC(24;0.065)			22	29					0	0	0.00278	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217516	150217516	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:150217516G>A	uc003whk.2	+	2	584	c.454G>A	c.(454-456)GGC>AGC	p.G152S		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	152							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCGGATGTGGGCCTAAAAAG	0.502			NA											14	23					0	0	0.001855	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269373	150269373	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr7:150269373G>T	uc003whl.2	+	3	297	c.215G>T	c.(214-216)CGC>CTC	p.R72L	GIMAP4_uc011kuu.1_Intron|GIMAP4_uc011kuv.1_Missense_Mutation_p.R86L	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	72							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTGAGAAACGCAGCAGCTCA	0.483			NA											14	32					6.72482e-11	8.95362e-11	0.003163	1	0
COPS5	10987	broad.mit.edu	37	8	67974210	67974210	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr8:67974210T>C	uc003xxe.2	-	1	353	c.22A>G	c.(22-24)ATG>GTG	p.M8V	CSPP1_uc003xxg.1_5'Flank|CSPP1_uc003xxh.1_5'Flank|CSPP1_uc003xxi.2_5'Flank|CSPP1_uc003xxj.2_5'Flank|COPS5_uc003xxd.2_5'UTR|COPS5_uc003xxf.2_Silent_p.V36V|COPS5_uc010lyv.1_Missense_Mutation_p.M8V	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	8					cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TTCTGGGCCATACCGCTCCCG	0.537			NA											46	163					0	0	0.003214	0	0
LRRCC1	85444	broad.mit.edu	37	8	86035739	86035739	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr8:86035739A>C	uc003ycw.2	+	7	1176	c.1022A>C	c.(1021-1023)AAA>ACA	p.K341T	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Missense_Mutation_p.K42T|LRRCC1_uc003ycx.2_Missense_Mutation_p.K248T|LRRCC1_uc003ycy.2_Missense_Mutation_p.K321T	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	341					cell division|mitosis	centriole|nucleus					0						GGAAACAGAAAAGAATGCAAT	0.323			NA											20	144					0	0	0.008871	0	0
GDF6	392255	broad.mit.edu	37	8	97157010	97157010	+	Silent	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr8:97157010G>A	uc003yhp.2	-	2	1249	c.1149C>T	c.(1147-1149)TGC>TGT	p.C383C		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	383					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					ATACACCCTCGCAGTGATAGG	0.637			NA											8	27					0	0	0.004482	0	0
TYRP1	7306	broad.mit.edu	37	9	12695518	12695518	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr9:12695518G>T	uc003zkv.3	+	3	567	c.389G>T	c.(388-390)AGG>ATG	p.R130M		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	130	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		CCTAAAGTCAGGAGAAATCTT	0.433			NA							Oculocutaneous_Albinism				29	18					8.88839e-20	1.32756e-19	0.002096	1	0
Unknown	0	broad.mit.edu	37	9	78965780	78965780	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr9:78965780G>T	uc004akc.1	+	8	1398	c.1178G>T	c.(1177-1179)AGT>ATT	p.S393I						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.												NA						TGTGTGTGGAGTTACCACCTC	0.483			NA											25	78					5.24475e-26	8.60582e-26	0.004656	1	0
CRB2	286204	broad.mit.edu	37	9	126125191	126125191	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr9:126125191G>A	uc004bnx.1	+	2	234	c.142G>A	c.(142-144)GCT>ACT	p.A48T	CRB2_uc004bnw.1_Missense_Mutation_p.A48T	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	48	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						AGACCCGTGCGCTCCAGGGAC	0.647			NA											92	21					0	0	0.00361	0	0
MED27	9442	broad.mit.edu	37	9	134738450	134738450	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr9:134738450C>A	uc004cbe.1	-	7	823	c.801G>T	c.(799-801)ATG>ATT	p.M267I	MED27_uc004cbf.1_Missense_Mutation_p.M231I	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	267					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		AGCCACTTACCATGAAGGATC	0.537	Colon(41;784 923 6932 42329 52483)		NA											24	8					4.72057e-08	5.81954e-08	0.003954	1	0
GTF3C4	9329	broad.mit.edu	37	9	135553983	135553983	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr9:135553983G>A	uc010mzv.2	+	2	1235	c.977G>A	c.(976-978)CGA>CAA	p.R326Q	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	326					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		CACAATAATCGAAAAATGAGT	0.413	Pancreas(142;417 1875 11086 31973 47667)		NA											98	34					0	0	0.00361	0	0
FAM47B	170062	broad.mit.edu	37	X	34962130	34962130	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chrX:34962130G>T	uc004ddi.1	+	1	1200	c.1182G>T	c.(1180-1182)ATG>ATT	p.M394I		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	394										ovary(3)|breast(1)	4						AGAGTCGGATGCCCCATCTCC	0.582			NA											24	5					1.1804e-14	1.67703e-14	0.003954	1	0
NAP1L2	4674	broad.mit.edu	37	X	72434052	72434052	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chrX:72434052C>A	uc004ebi.2	-	1	633	c.277G>T	c.(277-279)GGT>TGT	p.G93C	NAP1L2_uc011mqj.1_Intron	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	93					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					AAAACATAACCGATAAGTCCT	0.448			NA											42	19					2.54354e-34	4.32587e-34	0.002222	1	0
ESPNP	284729	broad.mit.edu	37	1	17034125	17034126	+	Frame_Shift_Ins	INS	-	-	AGCT	rs141324796	by1000genomes	TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr1:17034125_17034126insAGCT	uc001azn.1	-	3	478_479	c.364_365insAGCT	c.(364-366)TGGfs	p.W122fs	ESPNP_uc010ocj.1_Frame_Shift_Ins_p.W52fs	NR_026567				RecName: Full=Espin; AltName: Full=Ectoplasmic specialization protein; AltName: Full=Autosomal recessive deafness type 36 protein;												0						CAGCAGCAGCCAGCTGAGCACC	0.663			NA											4	3	---	---	---	---	NA	NA	NA	NA	NA
SLIT1	6585	broad.mit.edu	37	10	98799774	98799774	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr10:98799774delG	uc001kmw.2	-	21	2520	c.2268delC	c.(2266-2268)CCCfs	p.P756fs	SLIT1_uc009xvh.1_Frame_Shift_Del_p.P766fs	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	756	LRRNT 4.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GAATGCCCTTGGGCAGGGCCC	0.652			NA											17	41	---	---	---	---	NA	NA	NA	NA	NA
ZNF592	9640	broad.mit.edu	37	15	85341834	85341834	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr15:85341834delC	uc002bld.2	+	8	3088	c.2752delC	c.(2752-2754)CCCfs	p.P918fs	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	918					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCACGGTGTTCCCCGAAATGT	0.607			NA											23	42	---	---	---	---	NA	NA	NA	NA	NA
HYDIN	54768	broad.mit.edu	37	16	70975590	70975590	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr16:70975590delG	uc002ezr.2	-	43	6927	c.6799delC	c.(6799-6801)CAGfs	p.Q2267fs		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2268	Potential.									ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GCGTAATCCTGGGCCATGTTG	0.527			NA											15	196	---	---	---	---	NA	NA	NA	NA	NA
KIAA1267	284058	broad.mit.edu	37	17	44172067	44172067	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr17:44172067delC	uc002ikb.2	-	2	1375	c.1290delG	c.(1288-1290)CTGfs	p.L430fs	KIAA1267_uc002ikc.2_Frame_Shift_Del_p.L430fs|KIAA1267_uc002ikd.2_Frame_Shift_Del_p.L430fs|KIAA1267_uc010dav.2_Frame_Shift_Del_p.L430fs	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	430						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				ACCTGCGTCTCCTAAAAGGAA	0.463			NA											42	112	---	---	---	---	NA	NA	NA	NA	NA
ZNF331	55422	broad.mit.edu	37	19	54080642	54080653	+	In_Frame_Del	DEL	TGGGAAGGCTTT	TGGGAAGGCTTT	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	TGGGAAGGCTTT	TGGGAAGGCTTT	-	-	TGGGAAGGCTTT	TGGGAAGGCTTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr19:54080642_54080653delTGGGAAGGCTTT	uc002qbx.1	+	7	2262_2273	c.828_839delTGGGAAGGCTTT	c.(826-840)TGTGGGAAGGCTTTT>TGT	p.GKAF277del	ZNF331_uc002qby.1_In_Frame_Del_p.GKAF277del|ZNF331_uc002qbz.1_In_Frame_Del_p.GKAF277del|ZNF331_uc002qca.1_In_Frame_Del_p.GKAF277del|ZNF331_uc010eqr.1_In_Frame_Del_p.GKAF277del|ZNF331_uc002qcb.1_In_Frame_Del_p.GKAF277del|ZNF331_uc002qcc.1_In_Frame_Del_p.GKAF277del|ZNF331_uc002qcd.1_In_Frame_Del_p.GKAF277del	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	277_280	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		GTAAAGACTGTGGGAAGGCTTTTATTTGTGGT	0.42			NA	T	?	follicular thyroid adenoma								18	48	---	---	---	---	NA	NA	NA	NA	NA
REG3G	130120	broad.mit.edu	37	2	79255038	79255038	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr2:79255038delG	uc002snw.2	+	5	524	c.439delG	c.(439-441)GGGfs	p.G147fs	REG3G_uc002snx.2_Frame_Shift_Del_p.G147fs|REG3G_uc010ffu.2_Frame_Shift_Del_p.G101fs	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	147	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TGGCCACTGTGGGAGCCTGTC	0.488			NA											30	74	---	---	---	---	NA	NA	NA	NA	NA
XRN1	54464	broad.mit.edu	37	3	142123826	142123826	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr3:142123826delC	uc003eus.2	-	16	1873	c.1806delG	c.(1804-1806)TGGfs	p.W602fs	XRN1_uc010huu.2_Frame_Shift_Del_p.W68fs|XRN1_uc003eut.2_Frame_Shift_Del_p.W602fs|XRN1_uc003euu.2_Frame_Shift_Del_p.W602fs|XRN1_uc003euv.1_Frame_Shift_Del_p.W463fs	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	602					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						CTCTATCATACCAGCACATTA	0.403			NA											38	19	---	---	---	---	NA	NA	NA	NA	NA
KIAA1045	23349	broad.mit.edu	37	9	34972519	34972519	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-7713-01A-11D-2063-08	TCGA-86-7713-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1416b4c9-f535-4611-b4b9-85fbd0f7b0a4	4929c3d1-f4da-4766-9d13-85b5c7babf4c	g.chr9:34972519delC	uc003zvq.2	+	3	733	c.555delC	c.(553-555)TGCfs	p.C185fs	KIAA1045_uc003zvr.2_Frame_Shift_Del_p.C185fs	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	185	PHD-type.						calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			GCTGGAGCTGCCACTACTGTG	0.557			NA											23	18	---	---	---	---	NA	NA	NA	NA	NA